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179 results on '"Takakuwa, Emi"'

4. Evaluating Cellularity Estimation Methods: Comparing AI Counting with Pathologists’ Visual Estimates

Author

Kiyuna, Tomoharu, primary, Cosatto, Eric, additional, Hatanaka, Kanako C., additional, Yokose, Tomoyuki, additional, Tsuta, Koji, additional, Motoi, Noriko, additional, Makita, Keishi, additional, Shimizu, Ai, additional, Shinohara, Toshiya, additional, Suzuki, Akira, additional, Takakuwa, Emi, additional, Takakuwa, Yasunari, additional, Tsuji, Takahiro, additional, Tsujiwaki, Mitsuhiro, additional, Yanai, Mitsuru, additional, Yuzawa, Sayaka, additional, Ogura, Maki, additional, and Hatanaka, Yutaka, additional

Published
2024
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7. Observation of notable therapeutic response in a patient with systemic juvenile xanthogranuloma with KIF5B-ALK fusion

Author

Sugiyama, Minako, primary, Hirabayashi, Shinsuke, additional, Ishi, Yukitomo, additional, Kikuchi, Junko, additional, Ishikura, Ayako, additional, Motegi, Hiroaki, additional, Ueda, Yuki, additional, Sawai, Saori, additional, Hara, Kazuya, additional, Terashita, Yukayo, additional, Cho, Yuko, additional, Takakuwa, Emi, additional, Honda, Shohei, additional, Yamaguchi, Shigeru, additional, Kinoshita, Ichiro, additional, and Manabe, Atsushi, additional

Published
2024
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11. Recurrent 8q24 rearrangement in blastic plasmacytoid dendritic cell neoplasm: association with immunoblastoid cytomorphology, MYC expression, and drug response

Author

Sakamoto, Kana, Katayama, Ryohei, Asaka, Reimi, Sakata, Seiji, Baba, Satoko, Nakasone, Hideki, Koike, Sumie, Tsuyama, Naoko, Dobashi, Akito, Sasaki, Makoto, Ichinohasama, Ryo, Takakuwa, Emi, Yamazaki, Rie, Takizawa, Jun, Maeda, Takahiro, Narita, Miwako, Izutsu, Koji, Kanda, Yoshinobu, Ohshima, Koichi, and Takeuchi, Kengo

Published
2018
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13. Deep fibrous histiocytoma of the index finger: a case report

Author

Shibayama, Hiroki, primary, Matsui, Yuichiro, additional, Kawamura, Daisuke, additional, Momma, Daisuke, additional, Endo, Takeshi, additional, Matsui, Yuki, additional, Yawaka, Yasutaka, additional, Hatanaka, Kanako C., additional, Takakuwa, Emi, additional, Sugino, Hirokazu, additional, Hatanaka, Yutaka, additional, Hasegawa, Tadashi, additional, and Iwasaki, Norimasa, additional

Published
2023
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16. Cystic Intracranial Recurrence of Olfactory Neuroblastoma without Accumulation on Fluorine-18-fluorodeoxyglucose Positron Emission Tomography

Author

Ishi, Yukitomo, Yamaguchi, Shigeru, Hatanaka, Kanako C., Takakuwa, Emi, Motegi, Hiroaki, Honda, Taishi, Kobayashi, Hiroyuki, Terasaka, Shunsuke, Homma, Akihiro, Fujimura, Miki, and Houkin, Kiyohiro

Subjects
olfactory neuroblastoma, intracranial recurrence, esthesioneuroblastoma, fluorine-18-fluorodeoxyglucose positron emission tomography, cystic recurrence
Abstract

A 66-year-old man underwent multimodal treatment for olfactory neuroblastoma (ONB). When he was 72 years old, a cystic intracranial lesion without accumulation on fluorine-18-fluorodeoxyglucose positron emission tomography was detected. Surgical resection was performed when the patient was 73 years old. The pathological examination revealed recurrence of ONB, and the patient underwent focal irradiation. At age 81, he presented with a second recurrence in the right occipital lobe with radiological and pathological findings similar to the prior recurrence. This case suggests that pathological confirmation should be considered in cases with atypical radiological findings following the treatment of ONB.

Published
2022

18. Deep fibrous histiocytoma of the index finger: a case report

Author

Shibayama, Hiroki, Matsui, Yuichiro, Kawamura, Daisuke, Momma, Daisuke, Endo, Takeshi, Matsui, Yuki, Yawaka, Yasutaka, Hatanaka, Kanako C., Takakuwa, Emi, Sugino, Hirokazu, Hatanaka, Yutaka, Hasegawa, Tadashi, and Iwasaki, Norimasa

Subjects
Automotive Engineering
Abstract

Our patient presented with an elastic soft mass of his left index finger. Hematoxylin and eosin staining showed a high cellular density with spindle-shaped cells in a storiform pattern. Immunohistochemical staining was positive for CD68, factor XIIIa and α-smooth muscle actin, and negative for CD34, STAT6, S100 protein, and desmin.

Published
2023
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20. Long-term consequences of residual lesions after chemoradiotherapy in patients with germinoma at onset

Author

Yamaguchi, Shigeru, primary, Okamoto, Michinari, additional, Ishi, Yukitomo, additional, Sawaya, Ryosuke, additional, Motegi, Hiroaki, additional, Sugiyama, Minako, additional, Harada, Taisuke, additional, Fujima, Noriyuki, additional, Mori, Takashi, additional, Hashimoto, Takayuki, additional, Takakuwa, Emi, additional, Manabe, Atsushi, additional, Kudo, Kohsuke, additional, Aoyama, Hidefumi, additional, and Fujimura, Miki, additional

Published
2022
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22. High-grade neuroepithelial tumor with BCL6 corepressor-alteration presenting pathological and radiological calcification: A case report

Author

Ishi, Yukitomo, Shimizu, Ai, Takakuwa, Emi, Sugiyama, Minako, Okamoto, Michinari, Motegi, Hiroaki, Hirabayashi, Shinsuke, Cho, Yuko, Iguchi, Akihiro, Manabe, Atsushi, Nobusawa, Sumihito, Tanaka, Shinya, and Yamaguchi, Shigeru

Subjects
PNET, pediatric, high-grade neuroepithelial tumor, BCOR
Abstract

A 5-year-old girl presented with headache and vomiting. Head computed tomography and magnetic resonance imaging showed a right frontal lobe tumor with marked calcification. The patient underwent resection surgery with suspicion of anaplastic ependymoma, and the tumor was gross totally removed. Pathological examination revealed areas of dense tumor cells with a high nucleocytoplasmic ratio and myxoid areas consisting of tumor cells with a round-shaped nucleus and eosinophilic cytoplasm. Perivascular pseudorosette, necrosis, circumscribed growth, and microcalcification were also observed. Immunohistochemistry demonstrated negative staining for glial fibrillary protein and epithelial membrane antigen. Diagnosis of a high-grade neuroepithelial tumor (HGNET) with BCL6 corepressor (BCOR) alteration was made based on pathological findings and internal tandem duplication in the exon 15 of BCOR. Although calcification on radiological and pathological examination is not typical, it would be essential to recognize that calcification could appear in HGNET-BCOR.

Published
2021

23. Antiretroviral therapy achieved metabolic complete remission of hepatic AIDS related Epstein-Barr virus-associated smooth muscle tumor

Author

Ara, Takahide, primary, Endo, Tomoyuki, additional, Goto, Hideki, additional, Kasahara, Kohei, additional, Hasegawa, Yuta, additional, Yokoyama, Shota, additional, Shiratori, Souichi, additional, Nakagawa, Masao, additional, Kuwahara, Ken, additional, Takakuwa, Emi, additional, Hashino, Satoshi, additional, and Teshima, Takanori, additional

Published
2022
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26. O12-4 Clinical significance of comprehensive genomic profiling in pediatric cancer patients

Author

Sugiyama, Minako, primary, Kikuchi, Junko, additional, Ohhara, Yoshihito, additional, Hagio, Kanako, additional, Amano, Toraji, additional, Takakuwa, Emi, additional, Kanako Hatanaka, C., additional, Hatanaka, Yutaka, additional, Manabe, Atsushi, additional, Sarashina, Takeo, additional, Yamamoto, Masaki, additional, Mizukami, Yusuke, additional, Takada, Kohichi, additional, Naruse, Hirohiro, additional, Mitamura, Takashi, additional, Yabe, Ichiro, additional, Sakurai, Akihiro, additional, Dosaka-Akita, Hirotoshi, additional, and Kinoshita, Ichiro, additional

Published
2022
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27. Antiretroviral therapy achieved metabolic complete remission of hepatic AIDS related Epstein-Barr virus-associated smooth muscle tumor

Author

Ara, Takahide, Endo, Tomoyuki, Goto, Hideki, Kasahara, Kohei, Hasegawa, Yuta, Yokoyama, Shota, Shiratori, Souichi, Nakagawa, Masao, Kuwahara, Ken, Takakuwa, Emi, Hashino, Satoshi, Teshima, Takanori, Ara, Takahide, Endo, Tomoyuki, Goto, Hideki, Kasahara, Kohei, Hasegawa, Yuta, Yokoyama, Shota, Shiratori, Souichi, Nakagawa, Masao, Kuwahara, Ken, Takakuwa, Emi, Hashino, Satoshi, and Teshima, Takanori

Abstract

Epstein-Barr virus-associated smooth muscle tumor (EBV-SMT) is a rare mesenchymal tumor which occurs in immunocompromised patients. The immune status is an important factor in the treatment of EBV-SMTs, but the efficacy of antiretroviral therapy (ART) is not elucidated in acquired immune deficiency syndrome (AIDS) related EBV-SMTs. Here, we report the first successful case of a 29-year-old man with hepatic AIDS related EBV-SMT treated with ART solely. Positron emission tomography scan was useful for the evaluation of disease status. Recent advances in ART that enables to restore patient's immune status rapidly may change the treatment strategy in AIDS related EBV-SMT.

Published
2022

29. Delayed-onset Organizing Pneumonia Emerging after Recovery from Coronavirus Disease 2019: A Report of Three Cases Diagnosed Using Transbronchial Cryobiopsy and a Review of the Literature

Author

Nakakubo, Sho, primary, Kamada, Keisuke, additional, Yamashita, Yu, additional, Nakamura, Junichi, additional, Matsumoto, Munehiro, additional, Horii, Hiroshi, additional, Sato, Kazuki, additional, Morinaga, Daisuke, additional, Suzuki, Masaru, additional, Okazaki, Nanase, additional, Takakuwa, Emi, additional, Matsuno, Yoshihiro, additional, and Konno, Satoshi, additional

Published
2022
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31. Necrolytic migratory erythema-like eruptions induced by zinc deficiency during osimertinib treatment of EGFR-mutant non-small cell lung cancer: A case report

Author

Yamamoto, Gaku, primary, Asahina, Hajime, additional, Iwata, Hiroaki, additional, Takakuwa, Emi, additional, Ito, Shotaro, additional, Kunisaki, Mamoru, additional, Takashima, Yuta, additional, Kikuchi, Junko, additional, Kikuchi, Eiki, additional, Sakakibara-Konishi, Jun, additional, Shinagawa, Naofumi, additional, and Konno, Satoshi, additional

Published
2021
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32. Notable therapeutic response in a patient with systemic juvenile xanthogranuloma with KIF5B‐ALK fusion

Author

Sugiyama, Minako, primary, Hirabayashi, Shinsuke, additional, Ishi, Yukitomo, additional, Kikuchi, Junko, additional, Ishikura, Ayako, additional, Motegi, Hiroaki, additional, Ueda, Yuki, additional, Sawai, Saori, additional, Hara, Kazuya, additional, Terashita, Yukayo, additional, Cho, Yuko, additional, Takakuwa, Emi, additional, Honda, Shohei, additional, Yamaguchi, Shigeru, additional, Kinoshita, Ichiro, additional, and Manabe, Atsushi, additional

Published
2021
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35. Chronic Diarrhea as the Presenting Feature of Amyloidosis with Multiple Myeloma: A Case Report Diagnosed by a Myocardial Biopsy

Author

Otagiri, Shinsuke, Nakajima, Sae, Katsurada, Takehiko, Sakurai, Kensuke, Yamanashi, Kana, Are, Takahide, Takakuwa, Emi, Mitsuhashi, Ibmoko, Sakamoto, Naoya, Otagiri, Shinsuke, Nakajima, Sae, Katsurada, Takehiko, Sakurai, Kensuke, Yamanashi, Kana, Are, Takahide, Takakuwa, Emi, Mitsuhashi, Ibmoko, and Sakamoto, Naoya

Abstract

A 73-year-old woman with a history of diarrhea for one year and other various symptoms was admitted to our hospital. Gastrointestinal endoscopy that included enteroscopy with multiple biopsies was performed. However, no significant findings were observed. Electrocardiography showed low voltage in all limb leads, and an echocardiogram showed thickened cardiac walls with granular sparkling pattern. A myocardial biopsy revealed amyloidosis, and a bone marrow biopsy showed multiple myeloma. This case suggests that we should suspect the possibility of amyloidosis in a patient with diarrhea and various symptoms involving multiple organ systems. Additionally, electrocardiograms and echocardiograms should be performed even when gastrointestinal biopsies reveal negative results.

Published
2021

36. High-grade neuroepithelial tumor with BCL6 corepressor-alteration presenting pathological and radiological calcification: A case report

Author

1000030812284, Ishi, Yukitomo, Shimizu, Ai, Takakuwa, Emi, Sugiyama, Minako, Okamoto, Michinari, Motegi, Hiroaki, Hirabayashi, Shinsuke, Cho, Yuko, Iguchi, Akihiro, Manabe, Atsushi, Nobusawa, Sumihito, Tanaka, Shinya, Yamaguchi, Shigeru, 1000030812284, Ishi, Yukitomo, Shimizu, Ai, Takakuwa, Emi, Sugiyama, Minako, Okamoto, Michinari, Motegi, Hiroaki, Hirabayashi, Shinsuke, Cho, Yuko, Iguchi, Akihiro, Manabe, Atsushi, Nobusawa, Sumihito, Tanaka, Shinya, and Yamaguchi, Shigeru

Abstract

A 5-year-old girl presented with headache and vomiting. Head computed tomography and magnetic resonance imaging showed a right frontal lobe tumor with marked calcification. The patient underwent resection surgery with suspicion of anaplastic ependymoma, and the tumor was gross totally removed. Pathological examination revealed areas of dense tumor cells with a high nucleocytoplasmic ratio and myxoid areas consisting of tumor cells with a round-shaped nucleus and eosinophilic cytoplasm. Perivascular pseudorosette, necrosis, circumscribed growth, and microcalcification were also observed. Immunohistochemistry demonstrated negative staining for glial fibrillary protein and epithelial membrane antigen. Diagnosis of a high-grade neuroepithelial tumor (HGNET) with BCL6 corepressor (BCOR) alteration was made based on pathological findings and internal tandem duplication in the exon 15 of BCOR. Although calcification on radiological and pathological examination is not typical, it would be essential to recognize that calcification could appear in HGNET-BCOR.

Published
2021

38. A case of Epstein–Barr virus‐associated lymphoepithelioma‐like carcinoma of the colon

Author

Kanno‐Okada, Hiromi, primary, Takahashi, Kenta, additional, Katano, Harutaka, additional, Shimizu, Ai, additional, Takakuwa, Emi, additional, Miyamoto, Shuichi, additional, Abiko, Satoshi, additional, Yamamoto, Keiko, additional, Shimoda, Tadakazu, additional, Mitsuhashi, Tomoko, additional, Hasegawa, Hideki, additional, and Matsuno, Yoshihiro, additional

Published
2021
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41. Advanced pathological study for definite diagnosis of mitochondrial cardiomyopathy

Author

Takeda, Atsuhito, primary, Murayama, Kei, additional, Okazaki, Yasushi, additional, Imai-Okazaki, Atsuko, additional, Ohtake, Akira, additional, Takakuwa, Emi, additional, Yamazawa, Hirokuni, additional, Izumi, Gaku, additional, Abe, Jiro, additional, Nagai, Ayako, additional, Taniguchi, Kota, additional, Sasaki, Daisuke, additional, Tsujioka, Takao, additional, and Basgen, John M, additional

Published
2020
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44. Cytopathologic findings of cell block materials from the vitreous : Diagnostic distinction between intraocular lymphoma and non-lymphomatous diseases

Author

Kanno-Okada, Hiromi, Takakuwa, Emi, Tagawa, Yoshiaki, Kase, Satoru, Hatanaka, Kanako C., Hatanaka, Yutaka, Namba, Kenichi, Mitsuhashi, Tomoko, and Matsuno, Yoshihiro

Subjects
intraocular lymphoma, pathology, vitreous body
Abstract

Intraocular lymphoma is a rare neoplasm that occurs only in the eyes and/or central nervous system. Diagnosis of intraocular lymphoma is difficult because its clinical manifestations mimic chronic uveitis. Pathological examination of the vitreous is one of the main diagnostic tools for intraocular lymphoma, but this is challenging due to the sparse cellularity and specimen degeneration. Here, we reviewed 33 cell block preparations from vitreous perfusion fluid in order to examine the significance of cytopathological findings for differential diagnosis using vitreous samples. The cases comprised 12 intraocular lymphomas and 21 non-lymphomatous diseases. Cytologically, vitreous samples from non-lymphoma cases showed lower cellularity than the lymphoma cases. Whereas vitreous material from cases with infectious endophthalmitis showed prominent neutrophilic infiltration, material from sarcoidosis cases showed infiltration of small lymphoid cells, especially CD4-positive T cells. On the other hand, lymphoma cases showed higher cellularity, with large, irregular and atypical lymphoid cells, frequent necrotic cells in the background, and less pronounced neutrophil infiltration. Immunocytochemically, 11 of the 12 lymphoma cases were of the B-cell phenotype and the remaining case was of the T/NK-cell phenotype. In conclusion, careful cytopathological examination or immunocytochemistry of vitreous material facilitates appropriate diagnosis of intraocular lymphoma.

Published
2017

46. Lung metastasis from gastric cancer presenting as diffuse ground-glass opacities

Author

Abe, Yuki, 1000010374290, Suzuki, Masaru, Tsuji, Kosuke, Sato, Mineyoshi, 1000090789330, Kimura, Hirokazu, 1000060773314, Kimura, Hiroki, Nagaoka, Kentaro, Takakuwa, Emi, 1000000199829, Matsuno, Yoshihiro, 1000020399835, Konno, Satoshi, Abe, Yuki, 1000010374290, Suzuki, Masaru, Tsuji, Kosuke, Sato, Mineyoshi, 1000090789330, Kimura, Hirokazu, 1000060773314, Kimura, Hiroki, Nagaoka, Kentaro, Takakuwa, Emi, 1000000199829, Matsuno, Yoshihiro, 1000020399835, and Konno, Satoshi

Abstract

Most metastatic lung tumors display well-defined, round, multiple nodular shadows, whereas the presence of diffuse ground-glass opacities on chest computed tomography generally suggests non-malignant conditions. Here, we report an unusual case of pulmonary metastasis from gastric cancer in which diffuse ground-glass opacities were observed in all lung segments. A 59-year-old man with a 3-month history of worsening chest pain and shortness of breath was referred to the pulmonary clinic. Chest computed tomography revealed low attenuation areas, suggesting emphysema, along with diffuse ground-glass opacities and interlobular septal thickening in both lungs. A transbronchial lung biopsy specimen revealed signet-ring cell carcinoma infiltrating the alveolar septa. Immunohistochemical staining of the cancer cells was positive for CDX-2, cytokeratin 7, and cytokeratin 20, and negative for surfactant apoprotein-A, TTF-1, and Napsin A. Gastrointestinal endoscopy revealed an ulcerative tumor in the stomach, and a biopsy from the tumor demonstrated malignant cells with similar morphology and immunophenotypes as those in the lungs. The final diagnosis was diffuse lung metastasis from gastric cancer. Our case shows that although multiple, well-defined nodules are typically considered to be the classic presentation of pulmonary metastasis, clinicians should also be aware of the possibility of pulmonary metastasis presenting as diffuse ground-glass opacities.

Published
2020

50. A female case of pleuropulmonary blastoma type 1 whose pulmonary cystic lesion was followed since neonate

Author

Ohno, Michinobu, Takezoe, Toshiko, Watanabe, Toshihiko, Tahara, Kazunori, Hishiki, Tomoro, Fujino, Akihiro, Matsuo, Motomi, Higuchi, Masataka, Kawasaki, Kazuteru, Shioda, Yoko, Kato, Motohiro, Kiyotani, Chikako, Matsumoto, Kimikazu, Takakuwa, Emi, Irie, Rie, Yoshioka, Takako, Kimura, Shunsuke, Seki, Masafumi, Takita, Junko, and Kanamori, Yutaka

Published
2017
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