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Large magnitude snow avalanches pose a hazard to humans and infrastructure worldwide. Analyzing the spatiotemporal behavior of avalanches and the contributory climate factors is important for understanding historical variability in climate-avalanche relationships as well as improving avalanche forecasting. We used established dendrochronological methods to develop a long-term (1867–2019) regional avalanche chronology for the Rocky Mountains of northwest Montana using tree-rings from 647 trees exhibiting 2134 avalanche-related growth disturbances. We then used principal component analysis and a generalized linear autoregressive moving average model to examine avalanche-climate relationships. Historically, large magnitude regional avalanche years were characterized by stormy winters with positive snowpack anomalies, with avalanche years over recent decades increasingly influenced by warmer temperatures and a shallow snowpack. The amount of snowpack across the region, represented by the first principal component, is shown to be directly related to avalanche probability. Coincident with warming and regional snowpack reductions, a decline of ~ 14% (~ 2% per decade) in overall large magnitude avalanche probability is apparent through the period 1950–2017. As continued climate warming drives further regional snowpack reductions in the study region our results suggest a decreased probability of regional large magnitude avalanche frequency associated with winters characterized by large snowpacks and a potential increase in large magnitude events driven by warming temperatures and spring precipitation.

The Colorado River basin (CRB) supplies water to approximately 40 million people and is essential to hydropower generation, agriculture, and industry. In this study, a monthly water balance model is used to compute hydroclimatic water balance components (i.e., potential evapotranspiration, actual evapotranspiration, and runoff) for the period 1901–2014 across the entire CRB. The time series of monthly runoff is aggregated to compute water-year runoff and then used to identify drought periods in the basin. For the 1901–2014 period, eight basinwide drought periods were identified. The driest drought period spanned years 1901–04, whereas the longest drought period occurred during 1943–56. The eight droughts were primarily driven by winter precipitation deficits rather than warm temperature anomalies. In addition, an analysis of prehistoric drought for the CRB—computed using tree-ring-based reconstructions of the Palmer drought severity index—indicates that during some past centuries drought frequency was higher than during the twentieth century and that some centuries experienced droughts that were much longer than those during the twentieth century. More frequent or longer droughts than those that occurred during the twentieth century, combined with continued warming associated with climate change, may lead to substantial future water deficits in the CRB.

Across the Upper Missouri River Basin, the recent drought of 2000 to 2010, known as the “turn-of-the-century drought,” was likely more severe than any in the instrumental record including the Dust Bowl drought. However, until now, adequate proxy records needed to better understand this event with regard to long-term variability have been lacking. Here we examine 1,200 y of streamflow from a network of 17 new tree-ring–based reconstructions for gages across the upper Missouri basin and an independent reconstruction of warm-season regional temperature in order to place the recent drought in a long-term climate context. We find that temperature has increasingly influenced the severity of drought events by decreasing runoff efficiency in the basin since the late 20th century (1980s) onward. The occurrence of extreme heat, higher evapotranspiration, and associated low-flow conditions across the basin has increased substantially over the 20th and 21st centuries, and recent warming aligns with increasing drought severities that rival or exceed any estimated over the last 12 centuries. Future warming is anticipated to cause increasingly severe droughts by enhancing water deficits that could prove challenging for water management.

Cool- and warm-season precipitation totals have been reconstructed on a gridded basis for North America using 439 tree-ring chronologies correlated with December–April totals and 547 different chronologies correlated with May–July totals. These discrete seasonal chronologies are not significantly correlated with the alternate season; the December–April reconstructions are skillful over most of the southern and western United States and north-central Mexico, and the May–July estimates have skill over most of the United States, southwestern Canada, and northeastern Mexico. Both the strong continent-wide El Niño–Southern Oscillation (ENSO) signal embedded in the cool-season reconstructions and the Arctic Oscillation signal registered by the warm-season estimates faithfully reproduce the sign, intensity, and spatial patterns of these ocean–atmospheric influences on North American precipitation as recorded with instrumental data. The reconstructions are included in the North American Seasonal Precipitation Atlas (NASPA) and provide insight into decadal droughts and pluvials. They indicate that the sixteenth-century megadrought, the most severe and sustained North American drought of the past 500 years, was the combined result of three distinct seasonal droughts, each bearing unique spatial patterns potentially associated with seasonal forcing from ENSO, the Arctic Oscillation, and the Atlantic multidecadal oscillation. Significant 200–500-yr-long trends toward increased precipitation have been detected in the cool- and warm-season reconstructions for eastern North America. These seasonal precipitation changes appear to be part of the positive moisture trend measured in other paleoclimate proxies for the eastern area that began as a result of natural forcing before the industrial revolution and may have recently been enhanced by anthropogenic climate change.

National Science FoundationNational Science Foundation (NSF); Paleo Perspective on Climate Change (P2C2) [1401698, 1404188]; National Science Foundation, Water Sustainability and Climate (WSC)National Science Foundation (NSF) [1360446]; U.S. Department of EnergyUnited States Department of Energy (DOE) [DE-SC0018124]; U.S. Bureau of Reclamation WaterSMART Program (Sustain and Manage America's Resources for Tomorrow); state of Montana Department of Natural Resources and Conservation; U.S. Geological Survey Land Resources Mission Area; North Central Climate Adaptation Science Center; Lamont-Doherty Earth Observatory [8349]

Climate change is increasing the severity and extent of extreme droughts events, posing a critical threat to freshwater ecosystems, particularly with increasing human demands for diminishing water supplies. Despite the importance of drought as a significant driver of ecological and evolutionary dynamics, current understanding of drought consequences for freshwater biodiversity is very limited. We describe key barriers that hinder integrative drought research and monitoring across riverscapes. The primary constraint limiting understanding of ecological drought is an existing monitoring framework focused on human water consumption and flood risk in mainstem rivers. This approach is misaligned with escalating needs for research and data collection that illuminate exposure, sensitivity, and adaptive capacity (i.e., vulnerability) of biota to drought across entire riverscapes. We present a hierarchical framework for integrated ecological drought monitoring and research that addresses drought vulnerability across riverscapes and describe how this approach can directly inform natural-resource management.

Purpose of review Approximately one in four children with autism spectrum disorder (ASD) 'elope' or wander away from supervision each year; however, many caregivers do not receive adequate information on how to address wandering behavior. The purpose of this review is to summarize the available research on elopement frequency, wandering patterns, and interventions to provide pediatricians and other childcare professionals with appropriate strategies to address wandering behavior. Recent findings Despite the high prevalence of wandering by children with ASD or other developmental disabilities, there is relatively limited research in this area. Recent research has identified common patterns and factors associated with risk of elopement and elopement frequency. Summary Pediatricians should counsel families on the common issues and intervention strategies related to elopement. By increasing awareness of wandering in children with ASD, caregivers can feel better prepared to make informed decisions regarding their child's wellbeing and safety.

Paleoclimate records from ice cores generally are considered to be the most direct indicators of environmental change, but are rare from mid-latitude, continental regions such as the western United States. High-elevation ice patches are known to be important archaeological archives in alpine regions and potentially could provide records important for Earth System Model evaluation and to understand linkages between climate and early human activities, but this potential largely is unexplored. Here we use a well-dated ice-core record from a shallow ice patch to investigate Rocky Mountain winter-season climate during the Holocene. Our records indicate that this ice patch consistently accumulated ice over the past 10 kyr, preserving a regionally representative climate record of stable water isotopes and ice accretion rates that documented generally cooler and wetter conditions during the early Holocene and 500 years of anomalous winter season warmth centered at 4100 cal yr BP followed by a rapid cooling and 1500 years of cooler and wetter winters.

Warm summer temperatures and longer fire seasons are promoting larger, and in some cases, more fires that are severe in low- and mid-elevation, dry mixed-conifer forests of the Northern Rocky Mountains (NRM). Long-term historical fire conditions and human influence on past fire activity are not well understood for these topographically and biophysically heterogeneous forests. We developed reconstructions of millennial-scale fire activity, vegetation change, and human presence at Black Lake, a small closed-basin lake on the Flathead Indian Reservation in the Mission Valley, Northwestern Montana, United States. Fossil pollen, charcoal, and biomarkers associated with human presence were used to evaluate the interaction between climate variability, fire activity, vegetation change and human activity for the past 7000 years. Comparisons among multiple proxies suggest climate variability acted as the primary control on fire activity and vegetation change from the early Holocene until the late Holocene when records suggest fire activity and climate variability decoupled. Specific biomarkers (5β-stanols including coprostanol and epi-coprostanol) associated with human presence indicate humans were present within the Black Lake watershed for thousands of years, although the inferred intensity of human presence is highly variable. A strong relationship between climate variability and fire activity during the early and mid-Holocene weakens during the last few thousand years, suggesting possible increased influence of humans in mediating fire activity in recent millennia, and/or a shift in the interaction between the distribution and abundance of woody fuel and fire severity. Human-set fires during the cooler and wetter late Holocene may have been aimed at maintaining important cultural resources associated with the heterogeneous mosaic of mixed conifer forests within the Black Lake watershed. The paleoenvironmental reconstruction at Black Lake corroborates archeological records that show humans were present within the Black Lake watershed for over 7000 years. Further research is needed to evaluate the evidence for this continuous presence and the possible role that people played in shaping fire regimes and vegetation within low- to mid-elevation mixed-conifer ecosystems of the NRM.

Despite the importance of the Missouri River for navigation, recreation, habitat, hydroelectric power, and agriculture, relatively little is known about the basic hydroclimatology of the Missouri River basin (MRB). This is of particular concern given the droughts and floods that have occurred over the past several decades and the potential future exacerbation of these extremes by climate change. Here, observed and modeled hydroclimatic data and estimated natural flow records in the MRB are used to 1) assess the major source regions of MRB flow, 2) describe the climatic controls on streamflow in the upper and lower basins , and 3) investigate trends over the instrumental period. Analyses indicate that 72% of MRB runoff is generated by the headwaters in the upper basin and by the lowest portion of the basin near the mouth. Spring precipitation and temperature and winter precipitation impacted by changes in zonal versus meridional flow from the Pacific Ocean play key roles in surface water supply variability in the upper basin. Lower basin flow is significantly correlated with precipitation in late spring and early summer, indicative of Atlantic-influenced circulation variability affecting the flow of moisture from the Gulf of Mexico. Although increases in precipitation in the lower basin are currently overriding the effects of warming temperatures on total MRB flow, the upper basin’s long-term trend toward decreasing flows, reduction in snow versus rain fraction, and warming spring temperatures suggest that the upper basin may less often provide important flow supplements to the lower basin in the future.

Recent, widespread tree mortality in the western U.S. resulting from changes in climate, pathogens, insect activity, and forest management practices has led to concerns for many ecologically and culturally important species. Within conifers, resin-based defenses have long been recognized as a primary defense mechanism against a variety of insects and pathogens. Oleoresin produced by trees contain complex mixtures of terpenoids that have numerous insecticidal and fungicidal properties. Research has also identified links between resin duct characteristics and increased probability of survival during bark beetle outbreaks. Whitebark pine (Pinus albicaulis) is a culturally significant high elevation species that provides numerous ecological services within subalpine and alpine ecosystems. Whitebark pine has co-evolved with a suite of biotic and abiotic disturbances. Individual trees allocate resources towards growth and resin-based defenses, making it a good candidate species to evaluate growth and defense relationships and tradeoffs. In this study we compared constitutive resin chemistry, tree growth and resin duct anatomy between similarly aged whitebark and lodgepole pine (P. contorta var latifolia) growing in proximity within a disturbance-prone, mixed-conifer forest in northwestern Montana. These two host species have varying degrees of historical exposure to mountain pine beetle. Our research yields four important findings. First, we did not find evidence of a tradeoff between tree growth and tree defenses (resin duct morphology and resin chemistry). This suggests that trees growing under favorable field conditions can experience high growth rates and still allocate ample resources towards defense. Second, we found that resin ducts and constitutive mono- and sesqui- terpenes were not correlated in lodgepole pine while duct production and area were positively related to constitutive monoterpenes, and duct size and area were positively related to constitutive sesquiterpenes, in whitebark pine. The lack of distinct, consistent relationships between these defensive features suggests that both whitebark and lodgepole pine trees present beetles with numerous, complex combinations of resin-based defenses. Third, based on constitutive terpene profiles, bark beetles are more likely to enter lodgepole pine but more likely to successfully elicit mass attacks in whitebark pine, which agrees with beetle attack and success patterns observed in the field. Fourth, overstory competition, particularly by Engelmann spruce (Picea engelmannii), can influence tree defenses, specifically by reducing constitutive terpene concentrations in lodgepole and whitebark pine. Competitive tree interactions could lead to altered bark beetle-conifer interactions as host and nonhost species migrate in response to changing climate. Our results suggest that strategies designed to support whitebark pine populations can benefit from better understanding interactions among growth, competition and physical and chemical defenses in response to multiple disturbance.

The upper Colorado River basin (UCRB) is one of the primary sources of water for the western United States, and increasing temperatures likely will elevate the risk of reduced water supply in the basin. Although variability in water-year precipitation explains more of the variability in water-year UCRB streamflow than water-year UCRB temperature, since the late 1980s, increases in temperature in the UCRB have caused a substantial reduction in UCRB runoff efficiency (the ratio of streamflow to precipitation). These reductions in flow because of increasing temperatures are the largest documented temperature-related reductions since record keeping began. Increases in UCRB temperature over the past three decades have resulted in a mean UCRB water-year streamflow departure of −1306 million m3 (or −7% of mean water-year streamflow). Additionally, warm-season (April through September) temperature has had a larger effect on variability in water-year UCRB streamflow than the cool-season (October through March) temperature. The greater contribution of warm-season temperature, relative to cool-season temperature, to variability of UCRB flow suggests that evaporation or snowmelt, rather than changes from snow to rain during the cool season, has driven recent reductions in UCRB flow. It is expected that as warming continues, the negative effects of temperature on water-year UCRB streamflow will become more evident and problematic.

The Upper Fremont Glacier (UFG), Wyoming, is one of the few continental glaciers in the contiguous United States known to preserve environmental and climate records spanning recent centuries. A pair of ice cores taken from UFG have been studied extensively to document changes in climate and industrial pollution (most notably, mid-19th century increases in mercury pollution). Fundamental to these studies is the chronology used to map ice-core depth to age. Here, we present a revised chronology for the UFG ice cores based on new measurements and using a novel dating approach of synchronizing continuous water isotope measurements to a nearby tree-ring chronology. While consistent with the few unambiguous age controls underpinning the previous UFG chronologies, the new interpretation suggests a very different time scale for the UFG cores with changes of up to 80 years. Mercury increases previously associated with the mid-19th century Gold Rush now coincide with early-20th century industrial emissions, aligning the UFG record with other North American mercury records from ice and lake sediment cores. Additionally, new UFG records of industrial pollutants parallel changes documented in ice cores from southern Greenland, further validating the new UFG chronologies while documenting the extent of late 19th and early 20th century pollution in remote North America.

The unprecedented size of the 2017 wildfires that burned nearly 600,000 hectares of central Chile highlight a need to better understand the climatic conditions under which large fires develop. Here we evaluate synoptic atmospheric conditions at the surface and free troposphere associated with anomalously high (active) versus low (inactive) months of area burned in south-central Chile (ca. 32–41° S) from the Chilean Forest Service (CONAF) record of area burned from 1984–2018. Active fire months are correlated with warm surface temperatures, dry conditions, and the presence of a circumpolar assemblage of high-pressure systems located ca. 40°–60° S. Additionally, warm surface temperatures associated with active fire months are linked to reduced strength of cool, onshore westerly winds and an increase in warm, downslope Andean Cordillera easterly winds. Episodic warm downslope winds and easterly wind anomalies superimposed on long-term warming and drying trends will continue to create conditions that promote large fires in south-central Chile. Identifying the mechanisms responsible for easterly wind anomalies and determining whether this trend is strengthening due to synoptic-scale climatic changes such as the poleward shift in Southern Hemisphere westerly winds will be critical for anticipating future large fire activity in south-central Chile.

We developed Columbia River streamflow reconstructions using a network of existing, new, and updated tree-ring records sensitive to the main climatic factors governing discharge. Reconstruction quality is enhanced by incorporating tree-ring chronologies where high snowpack limits growth, which better represent the contribution of cool-season precipitation to flow than chronologies from trees positively sensitive to hydroclimate alone. The best performing reconstruction (back to 1609 CE) explains 59% of the historical variability and the longest reconstruction (back to 1502 CE) explains 52% of the variability. Droughts similar to the high-intensity, long-duration low flows observed during the 1920s and 1940s are rare, but occurred in the early 1500s and 1630s-1640s. The lowest Columbia flow events appear to be reflected in chronologies both positively and negatively related to streamflow, implying low snowpack and possibly low warm-season precipitation. High flows of magnitudes observed in the instrumental record appear to have been relatively common, and high flows from the 1680s to 1740s exceeded the magnitude and duration of observed wet periods in the late-19th and 20th Century. Comparisons between the Columbia River reconstructions and future projections of streamflow derived from global climate and hydrologic models show the potential for increased hydrologic variability, which could present challenges for managing water in the face of competing demands.

Large-scale atmospheric pressure centers, such as the Aleutian and Icelandic Low, have a demonstrated relationship with physical lake characteristics in contemporary monitoring studies, but the responses to these phenomena are rarely observed in lake records. We observe coherent changes in the stratification patterns of three deep (>30 m) lakes inferred from fossil diatom assemblages as a response to shifts in the location and intensity of the Aleutian Low and compare these changes with similar long-term changes observed in the δ18O record from the Yukon. Specifically, these records indicate that between 3.2 and 1.4 ka, the Aleutian Low shifted westward, resulting in an increased frequency of storm tracks across the Pacific Northwest during winter and spring. This change in atmospheric circulation ultimately produced deeper mixing in the upper waters of these three lake systems. Enhanced stratification between 4.5 and 3.3 ka and from 1.3 ka to present suggests a strengthened Aleutian Low and more meridional circulation.

This empirical study examines the influence of precipitation, temperature, and antecedent soil moisture on upper Colorado River basin (UCRB) water year streamflow over the past century. While cool season precipitation explains most of the variability in annual flows, temperature appears to be highly influential under certain conditions, with the role of antecedent fall soil moisture less clear. In both wet and dry years, when flow is substantially different than expected given precipitation, these factors can modulate the dominant precipitation influence on streamflow. Different combinations of temperature, precipitation, and soil moisture can result in flow deficits of similar magnitude, but recent droughts have been amplified by warmer temperatures that exacerbate the effects of relatively modest precipitation deficits. Since 1988, a marked increase in the frequency of warm years with lower flows than expected, given precipitation, suggests continued warming temperatures will be an increasingly important influence in reducing future UCRB water supplies.

Over the past decade, dendrochronologists have increasingly adopted the signal-free detrending (SFD) method to remove age-size trends in tree-ring measurement series, amplify the common stand-wide signal in composite chronologies, and recover medium- to low-frequency patterns that may be inadvertently removed by other detrending approaches. However, since its introduction in 2008, no systematic evaluation of the effects of SFD on tree-ring chronologies has been performed. Here we conduct the first review of SFD in dendrochronology and assess its effects when applied to large tree-ring networks. We analyzed the PAGES North America 2 K database of nearly 300 temperature-sensitive chronologies and the Missouri River database of over 350 chronologies curated for the purpose of reconstructing Missouri River streamflow. Both databases contain multiple versions of each chronology generated by different detrending methods, including those produced with (and without) the signal-free procedure applied. We evaluated (i) whether SFD increases chronology coherence at the site level by boosting the between-tree agreement, (ii) whether SFD increases coherence on a regional basis by making neighboring chronologies more similar to each other, and (iii) whether signal-free chronologies retained more medium- to low-frequency variability than their traditional counterparts. We find that, while SFD increased the strength of common signals in many instances, the effect was not universal and some sites even show a decrease in signal coherence. At regional scales, SFD increases chronology coherence in temperature-sensitive records but had no detectable effect on moisture-sensitive records. Our results demonstrate the importance of evaluating the effects of SFD prior to deploying this method for chronology development and paleoclimate reconstruction.

Whitebark pine (Pinus albicaulis) is a critical forest species of Northern Rocky Mountain upper subalpine ecosystems, yet little is known about the physiological response of whitebark pine to disturbance (e.g. fire, bark beetles, and pathogens) across a range of diverse environmental gradients. Resin-based defenses have long been recognized as the primary mechanism by which conifers respond to attack by bark beetles and pathogens and several studies have linked resin duct properties to survivorship during periods of increased beetle activity. However, to our knowledge, no studies have compared axial resin ducts in the secondary xylem of whitebark pine across pairs of living and dead whitebark pine trees to better understand survivorship following multiple disturbances including mountain pine beetle and white pine blister rust. We found a clear distinction in growth and defense characteristics between live and dead whitebark pine. Across our study sites on the Flathead Indian Reservation in northwestern Montana, live whitebark pine produced larger resin ducts with a greater annual investment in resin-based defenses than whitebark pine that died. Resin duct size, duct area, and relative duct area were all greater in live whitebark pine (by 56%, 48%, and 57%, respectively) and these were the most important variables influencing whitebark pine survivorship. In contrast, whitebark pine that had died grew faster over time (22% larger ring widths) than their live counterparts and also produced more resin duct structures (20% more ducts on average). Whitebark pine at our study sites exhibit differing strategies in the allocation of resources toward growth and defense, with the majority of survivors of recent disturbance investing more in defensive structures than growth. Our results support the idea that maintaining genetic variability and the associated suite of differing physiological traits promotes diverse response strategies to a complex array of biophysical and biological stressors that might leave a species vulnerable to extinction across its range.

Paleohydrologic reconstructions of water-year streamflow for 105 sites across the western United States (West) were used to compute the likelihood (risk) of regime (wet/dry state) shifts given the length of time in a specific regime and for a specified time in the future. The spatial variability of risks was examined and indicates that regime shift risks are variable across the West. The Pacific-Northwest region is associated with low risks of regime shifts, indicating persistence controlled by prevalent low frequency variability in flow (periods above 64 years). Other areas in the West indicate higher risks compared to the Pacific-Northwest due to flow variability in the mid-to-high frequencies (periods of 32 to 16 years). Understanding risks of regime shifts provides critical information for improved management of water supplies, particularly during periods of extended low flows. The method presented here has global applicability as a decision-making framework for risk-based planning and management.

A synthesis of 93 hydrologic records from across North and Central America, and adjacent tropical and Arctic islands, reveals centennial to millennial trends in the regional hydroclimates of the Common Era (CE; past 2000 years). The hydrological records derive from materials stored in lakes, bogs, caves, and ice from extant glaciers, which have the continuity through time to preserve low-frequency ( > 100 year) climate signals that may extend deeper into the Holocene. The most common pattern, represented in 46 (49 %) of the records, indicates that the centuries before 1000 CE were drier than the centuries since that time. Principal component analysis indicates that millennial-scale trends represent the dominant pattern of variance in the southwestern US, northeastern US, mid-continent, Pacific Northwest, Arctic, and tropics, although not all records within a region show the same direction of change. The Pacific Northwest and the southernmost tier of the tropical sites tended to dry toward present, as many other areas became wetter than before. In 22 records (24 %), the Medieval Climate Anomaly period (800–1300 CE) was drier than the Little Ice Age (1400–1900 CE), but in many cases the difference was part of the longer millennial-scale trend, and, in 25 records (27 %), the Medieval Climate Anomaly period represented a pluvial (wet) phase. Where quantitative records permitted a comparison, we found that centennial-scale fluctuations over the Common Era represented changes of 3–7 % in the modern interannual range of variability in precipitation, but the accumulation of these long-term trends over the entirety of the Holocene caused recent centuries to be significantly wetter, on average, than most of the past 11 000 years.

A synthesis of 93 hydrologic records from across North and Central America, and adjacent tropical and Arctic islands, reveals centennial to millennial trends in the regional hydroclimates of the Common Era (CE; past 2000 years). The hydrological records derive from materials stored in lakes, bogs, caves, and ice from extant glaciers, which have the continuity through time to preserve low-frequency (> 100 year) climate signals that may not be well represented by other shorter-lived archives, such as tree-ring chronologies. The most common pattern, represented in 46 (49 %) of the records, indicates that the centuries before 1000 CE were drier than the centuries since that time. Principal components analysis indicates that millennial-scale trends represent the dominant pattern of variance in the southwest and northeast U.S., the mid-continent, Pacific Northwest, the Arctic, and the tropics, although not all records within a region show the same direction of change. The Pacific Northwest, Greenland, and the southernmost tier of the tropical sites tended to dry toward present, as many other areas became wetter than before. Twenty-two records (24 %) indicate that the Medieval period (800–1300 CE) was drier than the Little Ice Age (1400–1900 CE), but in many cases the difference was part of the longer millennial-scale trend, and, in 25 records (27 %), the Medieval period represented a pluvial (wet) phase. Where quantitative records permitted a comparison, we found that centennial-scale fluctuations over the Common Era represented changes of 3–7 % of the modern inter-annual range of variability in precipitation, but the accumulation of these long-term trends over the entirety of the Holocene caused recent centuries to be significantly wetter, on average, than most of the past 11 000 years.

Paleohydrologic records can provide unique, long-term perspectives on streamflow variability and hydroclimate for use in water resource planning. Such long-term records can also play a key role in placing both present day events and projected future conditions into a broader context than that offered by instrumental observations. However, relative to other major river basins across the western United States, a paucity of streamflow reconstructions has to date prevented the full application of such paleohydrologic information in the Upper Missouri River Basin. Here we utilize a set of naturalized streamflow records for the Upper Missouri and an expanded network of tree-ring records to reconstruct streamflow at thirty-one gaging locations across the major headwaters of the basin. The reconstructions explain an average of 68% of the variability in the observed streamflow records and extend available records of streamflow back to 886 CE on average. Basin-wide analyses suggest unprecedented hydroclimatic variability over the region during the Medieval period, similar to that observed in the Upper Colorado River Basin, and show considerable synchrony of persistent wet-dry phasing with the Colorado River over the last 1200 years. Streamflow estimates in individual sub-basins of the Upper Missouri demonstrate increased spatial variability in discharge during the Little Ice Age (∼1400–1850 CE) compared with the Medieval Climate Anomaly (∼800–1400 CE). The network of streamflow reconstructions presented here fills a major geographical void in paleohydrologic understanding and now allows for a long-term assessment of hydrological variability over the majority of the western U.S.

Reproducible climate reconstructions of the Common Era (1 CE to present) are key to placing industrial-era warming into the context of natural climatic variability. Here we present a community-sourced database of temperature-sensitive proxy records from the PAGES2k initiative. The database gathers 692 records from 648 locations, including all continental regions and major ocean basins. The records are from trees, ice, sediment, corals, speleothems, documentary evidence, and other archives. They range in length from 50 to 2000 years, with a median of 547 years, while temporal resolution ranges from biweekly to centennial. Nearly half of the proxy time series are significantly correlated with HadCRUT4.2 surface temperature over the period 1850-2014. Global temperature composites show a remarkable degree of coherence between high- and low-resolution archives, with broadly similar patterns across archive types, terrestrial versus marine locations, and screening criteria. The database is suited to investigations of global and regional temperature variability over the Common Era, and is shared in the Linked Paleo Data (LiPD) format, including serializations in Matlab, R and Python., PAGES, a core project of Future Earth, is supported by the U.S. and Swiss National Science Foundations. Any use of trade, firm, or product names is for descriptive purposes only and does not imply endorsement by the U.S. Government. Some of this work was conducted as part of the North America 2k Working Group supported by the John Wesley Powell Center for Analysis and Synthesis, funded by the U.S. Geological Survey. B. Bauer, W. Gross, and E. Gille (NOAA National Centers for Environmental Information) are gratefully acknowledged for helping assemble the data citations and creating the NCEI versions of the PAGES 2k data records. We thank all the investigators whose commitment to data sharing enables the open science ethos embodied by this project.

The primary role of dystrophin, a 427 kDa elongated protein, is to stabilize the membrane of muscle cells against the mechanical forces deriving from muscle contraction and relaxation; its absence or mutation lead to various forms of muscular dystrophy. Dystrophin binds to actin through its N-terminus actin binding domain (ABD1), and connects to the cell membrane through its C-terminus; in between, 24 spectrin repeats (SR) with interspersed hinges provide structural flexibility and have been proposed to actively dissipate the mechanical stress. Yet, dystrophin's mechanism of function is largely unknown, preventing effective drug development. Our working hypothesis is that dystrophin's domains are allosterically coupled through specific hydrophobic interactions, and that the response to mechanical stress is propagated across domains through order-to-disorder transitions at their interface. We test this hypothesis with all-atom molecular dynamics simulations of dystrophin's SR 1 monomer, SR 17-18 dimer, and the ABD1 domain. Our results support the hypothesis by showing that (a) forced unfolding by pulling initiates at the interface between SR repeats; (b) the linker between SR 17-18 is flexible and allows for distinct conformations at the interface between domains, characterized by different hydrophobic interaction patterns; (c) mutual information analyses show that conformational changes at the dimer's interface and termini are coupled; and (d) hydrophobic interactions between the two CH domains and the connecting linker stabilize a closed conformation of ABD1 that is alternative to the open crystal structure and explains experimental fluorescence results. Our results suggest that the disease may originate from altered hydrophobic interactions, and pave the way for targeted drug development.

Knowledge of climatic variability at small spatial extents (< 50 km) is needed to assess vulnerabilities of biological reserves to climate change. We used empirical and modeled weather station data to test if climate change has increased the synchrony of surface air temperatures among 50 sites within the Greater Yellowstone Area (GYA) of the interior western United States. This important biological reserve is the largest protected area in the Lower 48 states and provides critical habitat for some of the world's most iconic wildlife. We focused our analyses on temporal shifts and shape changes in the annual distributions of seasonal minimum and maximum air temperatures among valley-bottom and higher elevation sites from 1948-2012. We documented consistent patterns of warming since 1948 at all 50 sites, with the most pronounced changes occurring during the Winter and Summer when minimum and maximum temperature distributions increased. These shifts indicate more hot temperatures and less cold temperatures would be expected across the GYA. Though the shifting statistical distributions indicate warming, little change in the shape of the temperature distributions across sites since 1948 suggest the GYA has maintained a diverse portfolio of temperatures within a year. Spatial heterogeneity in temperatures is likely maintained by the GYA's physiographic complexity and its large size, which encompasses multiple climate zones that respond differently to synoptic drivers. Having a diverse portfolio of temperatures may help biological reserves spread the extinction risk posed by climate change.