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47 results on '"Sudre, Guillaume"'

7. Structure of Surfaces and Interfaces of Poly( N,N -dimethylacrylamide) Hydrogels

Author

Sudre, Guillaume, Hourdet, Dominique, Cousin, Fabrice, Creton, Costantino, and Tran, Yvette

Subjects
Condensed Matter - Soft Condensed Matter
Abstract

We investigated the surface structure of hydrogels of poly(N,N-dimethylacrylamide) (PDMA) hydrogels synthesized and cross-linked simultaneously by redox free radical polymerization. We demonstrate the existence of a less cross-linked layer at the surface of the gel at least at two different length scales characterized by shear rheology and by neutron reflectivity, suggesting the existence of a gradient in cross-linking. The composition of the layer is shown to depend on the degree of hydrophobicity of the mold surface and is weaker for more hydrophobic molds. While the macroscopic tests proved the existence of a relatively thick under-cross-linked layer, we also demonstrated by neutron reflectivity that the gel surface at the submicrometric scale (500 nm) was also affected by the surface treatment of the mold. These results should have important implications for the measurement of macroscopic surface properties of these hydrogels such as friction or adhesion.

Published
2017
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14. Design, Processing, and Challenges of Multicomponent Polymer Composites for Improved Electromagnetic Interference Shielding Properties: A Review

Author

Li, Jixiang, primary, Masghouni, Emna, additional, Granger, Mathis, additional, Sudre, Guillaume, additional, Alcouffe, Pierre, additional, Muller, Didier, additional, Nguyen, Van Son, additional, Bayard, Bernard, additional, Serghei, Anatoli, additional, Sauviac, Bruno, additional, Maazouz, Abderrahim, additional, and Lamnawar, Khalid, additional

Published
2024
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15. Chitosan-Coated Superparamagnetic Fe3O4 Nanoparticles for Magnetic Resonance Imaging, Magnetic Hyperthermia, and Drug Delivery.

Author

Mistral, Jules, Ve Koon, Kevin Tse, Fernando Cotica, Luiz, Sanguino Dias, Gustavo, Aparecido Santos, Ivair, Alcouffe, Pierre, Milhau, Nadège, Pin, Didier, Chapet, Olivier, Serghei, Anatoli, Sudre, Guillaume, Ladavière, Catherine, Nunes De Oliveira, Paula, and David, Laurent

Abstract

Superparamagnetic iron oxide nanoparticles (SPIONs) have great potential for biomedical applications as multipurpose magnetic resonance imaging (MRI) contrast agents, and some systems have already been approved by The United States Food and Drug Administration for clinical use. Superparamagnetic behavior, high magnetic saturation, and fast synthesis are the major advantages of these nanomaterials. Polymer coatings are often used to prevent cluster formation and to improve biocompatibility of nanoparticles. In this work, we propose to use chitosan (CS) coatings as a means to tune the biocompatibility and magnetic properties of the SPIONs. For this purpose, magnetite (Fe3O4) SPIONs with various CS coatings were synthesized. CS with identical degree of polymerization (DPw = 450) but different degrees of acetylation (DA of 1, 14, and 34%) were employed to tune the hydrophilic properties of the SPIONs' coatings. A highly crystalline magnetite phase with a superparamagnetic behavior was evidenced for all the studied nanoparticles, whose average sizes varied between 5 and 10 nm. Adjusting the preparation process enabled us to control precisely the amount of coating on the SPIONs. Such coatings significantly impacted their magnetic properties, which were found to decrease with the quantity of CS and also with its DA. Interestingly, cytocompatibility was enhanced by the presence of the CS coating so that all CS-coated SPIONs studied were found to be nontoxic, regardless of the amount of coating. This trade-off approach suggests that optimal SPIONs systems would consist of a magnetite core, coated with a low amount of low-DA CS. Finally, the multimodal features of the SPIONs were evidenced by performing magnetic hyperthermia and MRI measurements. Despite significant differences, for all the CS-coated SPIONs, the magnetic properties remained strong enough to envision their use in various biomedical applications such as magnetic hyperthermia, MRI contrast agents, magnetic field-assisted drug delivery, and as platforms for further biological functionalization. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Cytocompatibility / Antibacterial Activity Trade-off for Knittable Wet-Spun Chitosan Monofilaments Functionalized by the In Situ Incorporation of Cu2+ and Zn2+

Author

Passieux, Renaud, primary, Sudre, Guillaume, additional, Montembault, Alexandra, additional, Renard, Martine, additional, Hagege, Agnès, additional, Alcouffe, Pierre, additional, Haddane, Ali, additional, Vandesteene, Marie, additional, Boucard, Nadège, additional, Bordenave, Laurence, additional, and David, Laurent, additional

Published
2022
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23. Development of Bioinspired Functional Chitosan/Cellulose Nanofiber 3D Hydrogel Constructs by 3D Printing for Application in the Engineering of Mechanically Demanding Tissues

Author

Kamdem Tamo, Arnaud, primary, Doench, Ingo, additional, Walter, Lukas, additional, Montembault, Alexandra, additional, Sudre, Guillaume, additional, David, Laurent, additional, Morales-Helguera, Aliuska, additional, Selig, Mischa, additional, Rolauffs, Bernd, additional, Bernstein, Anke, additional, Hoenders, Daniel, additional, Walther, Andreas, additional, and Osorio-Madrazo, Anayancy, additional

Published
2021
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28. In situ synthesis of Fe3O4 nanoparticles coated by chito-oligosaccharides: physico-chemical characterizations and cytotoxicity evaluation for biomedical applications

Author

de Oliveira, Paula Nunes, primary, Moussa, Amani, additional, Milhau, Nadège, additional, Dosciatti Bini, Raquel, additional, Prouillac, Caroline, additional, Ferraz de Oliveira, Breno, additional, Dias, Gustavo Sanguino, additional, Santos, Ivair Aparecido, additional, Morfin, Isabelle, additional, Sudre, Guillaume, additional, Alcouffe, Pierre, additional, Delair, Thierry, additional, Cótica, Luiz Fernando, additional, Trombotto, Stéphane, additional, Pin, Didier, additional, and David, Laurent, additional

Published
2020
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30. Cytocompatibility / Antibacterial Activity Trade-off for Knittable Wet-Spun Chitosan Monofilaments Functionalized by the In Situ Incorporation of Cu2+and Zn2+

Author

Passieux, Renaud, Sudre, Guillaume, Montembault, Alexandra, Renard, Martine, Hagege, Agnès, Alcouffe, Pierre, Haddane, Ali, Vandesteene, Marie, Boucard, Nadège, Bordenave, Laurence, and David, Laurent

Abstract

The wet spinning of cytocompatible, bioresorbable, and knittable chitosan (CTS) monofilaments would be advantageous for a variety of surgical applications. The complexation capacity of chitosan with Cu2+or Zn2+can be leveraged to enhance its antibacterial activity, but not at the expense of cytocompatibility. In this work, a wet-spinning process was adapted for the in situ incorporation of Cu2+or Zn2+with chitosan dopes to produce monofilaments at different drawing ratios (τtot) with various cation/glucosamine molar ratios, evaluated in the fibers (rCu,fand rZn,f). Cytocompatibility and antibacterial activity of wet-spun monofilaments were, respectively, quantified by in vitro live-dead assays on balb 3T3 and by different evaluations of the proliferation inhibition of Staphylococcus epidermidis(Gram+) and Escherichia coli(Gram−). Knittability was tested by a specific tensile test using a knitting needle and evaluated with an industrial knitting machine. It was found that rCu,f= 0.01 and rZn,f= 0.03 significantly increase the antibacterial activity without compromising cytocompatibility. Wet spinning with τtot= 1.6 allowed the production of knittable CTS-Cu monofilaments, as confirmed by knitting assays under industrial conditions.

Published
2022
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34. Cellulose Nanofiber-Reinforced Chitosan Hydrogel Composites for Intervertebral Disc Tissue Repair

Author

Doench, Ingo, primary, Tran, Tuan, additional, David, Laurent, additional, Montembault, Alexandra, additional, Viguier, Eric, additional, Gorzelanny, Christian, additional, Sudre, Guillaume, additional, Cachon, Thibaut, additional, Louback-Mohamed, Malika, additional, Horbelt, Niels, additional, Peniche-Covas, Carlos, additional, and Osorio-Madrazo, Anayancy, additional

Published
2019
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37. Intermolecular Interactions between Bottlebrush Polymers Boost the Protection of Surfaces against Frictional Wear

Author

Faivre, Jimmy, primary, Shrestha, Buddha Ratna, additional, Xie, Guojun, additional, Olszewski, Mateusz, additional, Adibnia, Vahid, additional, Moldovan, Florina, additional, Montembault, Alexandra, additional, Sudre, Guillaume, additional, Delair, Thierry, additional, David, Laurent, additional, Matyjaszewski, Krzysztof, additional, and Banquy, Xavier, additional

Published
2018
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39. Highly stretchable hydrogels obtained by controlled self-assembly of hyaluronic acid and chitosan and preparation thereof

Author

David Laurent, Sudre Guillaume, Meadows John, Montembault Alexandra, Laleve Gautier, Malaise Sbastien, and Delair Thierry

Subjects
Chitosan, chemistry.chemical_compound, Histology, chemistry, Chemical engineering, Hyaluronic acid, Self-healing hydrogels, Biomedical Engineering, Bioengineering, Self-assembly, Biotechnology
Published
2016
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40. Dynamic Structuration of Physical Chitosan Hydrogels

Author

Sereni, Nicolas, primary, Enache, Alin, additional, Sudre, Guillaume, additional, Montembault, Alexandra, additional, Rochas, Cyrille, additional, Durand, Philippe, additional, Perrard, Marie-Hélène, additional, Bozga, Grigore, additional, Puaux, Jean-Pierre, additional, Delair, Thierry, additional, and David, Laurent, additional

Published
2017
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45. Development of Breathable Pebax ® /PEG Films for Optimization of the Shelf-Life of Fresh Agri-Food Products.

Author

Préfol, Thibaut, Gain, Olivier, Sudre, Guillaume, Gouanvé, Fabrice, and Espuche, Eliane

Subjects
EDIBLE coatings, POLYETHYLENE glycol, DIFFERENTIAL scanning calorimetry, X-ray scattering, FOOD packaging, METHYL ether
Abstract

In this work, thin transparent breathable films were prepared for food packaging applications. The films were obtained by the solvent casting method from both the binary blends Pebax® MH1657 copolymer/ hydroxyl-terminated polyethylene glycol (PEGOH) and Pebax® MH1657/polyethylene glycol dimethyl ether (PEGDME) as well as the ternary blend Pebax® MH1657/PEGOH/PEGDME with a 50/50 and 37.5/62.5 PEGOH/PEGDME weight ratio for additive amounts comprised between 0 and 50 wt.%. The microstructure of these materials was investigated by differential scanning calorimetry (DSC) and wide-angle X-ray scattering (WAXS) analyses. Regardless of the PEG's nature, for a PEG amount inferior to 30 wt.%, the Pebax® and PEG phases were totally miscible. For higher amounts, a phase separation was obtained. In the presence of PEG, a decrease in crystallinity was obtained. The effects of the nature and amount of PEG on the thermo-mechanical, hydration, and gas (CO2, O2) transport properties were investigated. A study of the film's stability in terms of composition over time was also performed. From this work, a wide range of films could be proposed with a stable composition over time and adjustable mechanical and gas transport properties for the prolongation of the shelf-life of highly breathable fresh products. [ABSTRACT FROM AUTHOR]

Published
2021
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46. Cytocompatibility / Antibacterial Activity Trade-off for Knittable Wet-Spun Chitosan Monofilaments Functionalized by the In Situ Incorporation of Cu 2+ and Zn 2 .

Author

Passieux R, Sudre G, Montembault A, Renard M, Hagege A, Alcouffe P, Haddane A, Vandesteene M, Boucard N, Bordenave L, and David L

Subjects
Anti-Bacterial Agents pharmacology, Escherichia coli, Zinc pharmacology, Chitosan pharmacology
Abstract

The wet spinning of cytocompatible, bioresorbable, and knittable chitosan (CTS) monofilaments would be advantageous for a variety of surgical applications. The complexation capacity of chitosan with Cu 2+ or Zn 2+ can be leveraged to enhance its antibacterial activity, but not at the expense of cytocompatibility. In this work, a wet-spinning process was adapted for the in situ incorporation of Cu 2+ or Zn 2+ with chitosan dopes to produce monofilaments at different drawing ratios (τ tot ) with various cation/glucosamine molar ratios, evaluated in the fibers ( r Cu,f and r Zn,f ). Cytocompatibility and antibacterial activity of wet-spun monofilaments were, respectively, quantified by in vitro live-dead assays on balb 3T3 and by different evaluations of the proliferation inhibition of Staphylococcus epidermidis (Gram+) and Escherichia coli (Gram-). Knittability was tested by a specific tensile test using a knitting needle and evaluated with an industrial knitting machine. It was found that r Cu,f = 0.01 and r Zn,f = 0.03 significantly increase the antibacterial activity without compromising cytocompatibility. Wet spinning with τ tot = 1.6 allowed the production of knittable CTS-Cu monofilaments, as confirmed by knitting assays under industrial conditions.

Published
2022
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47. In situ synthesis of Fe 3 O 4 nanoparticles coated by chito-oligosaccharides: physico-chemical characterizations and cytotoxicity evaluation for biomedical applications.

Author

de Oliveira PN, Moussa A, Milhau N, Dosciatti Bini R, Prouillac C, Ferraz de Oliveira B, Dias GS, Santos IA, Morfin I, Sudre G, Alcouffe P, Delair T, Cótica LF, Trombotto S, Pin D, and David L

Subjects
Acetylation, Animals, Cell Line, Cell Survival drug effects, Dogs, Drug Delivery Systems, Oligosaccharides chemistry, Particle Size, Solubility, Chitosan chemistry, Magnetite Nanoparticles chemistry, Oligosaccharides pharmacology
Abstract

Fe 3 O 4 nanoparticles coated with chito-oligosaccharides (COS) were prepared in situ by a simple co-precipitation method through a mixing of iron ions (Fe 3+ and Fe 2+ ) and COS aqueous solutions followed by precipitation with ammonia. The impact of COS with different degree of polymerization (DP 10, 24 and 45) and degree of N-acetylation (DA) ∼ 24% and 50% (exhibiting high solubility) on the synthesis and physical properties of the coated magnetic nanoparticles was evaluated. Several advantages were found when the magnetic nanoparticles were prepared in the presence of the studied COS, such as: preparation of functionalized magnetic nanoparticles with narrower size distributions and, consequently, higher saturation magnetization (an increase of up to 22%); and an expressive increasing in the concentration of COS-coated magnetic nanoparticles (up to twice) in the cell viability test in comparison with pure Fe 3 O 4 nanoparticles. Furthermore, among the analyzed samples, the magnetic nanoparticles coated by COS with DA ∼ 50% present a higher cytocompatibility. Our results allow envisioning various biomedical applications, valorizing the use of coated-magnetic nanoparticles for magnetic-field assisted drug delivery, enzyme or cell immobilization, or as a marker for specific cell tracking, among others.

Published
2020
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