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134 results on '"Stevens-Kroef, Marian"'

1. 10-day decitabine versus 3 + 7 chemotherapy followed by allografting in older patients with acute myeloid leukaemia: an open-label, randomised, controlled, phase 3 trial

Author

Finke, Jürgen, Schaap, Nicolaas Petrus Michael, Zucenka, Andrius, Metzelder, Stephan, Jost, Edgar, Perić, Zinaida, Forghieri, Fabio, Allione, Bernadino, Martelli, Maurizio, Iori, Anna Paola, Wittnebel, Sebastian, Mengarelli, Andrea, Imovilli, Annalisa, Olivieri, Attilio, De Prijck, Bernard José Marie, van der Poel, Marjolein W.M., Junghanß, Christian, Salih, Helmut Rainer, Tafuri, Agostino, Guimarães, José Eduardo, Musso, Maurizio, De Fabritiis, Paolo, Chevallier, Patrice, Selleslag, Dominik Luc, Cascavilla, Nicola, Berneman, Zwi, Jaspers, Aurélie, Zuffa, Eliana, Vanstraelen, Gaëtan, Visani, Giuseppe, Cuijpers, Maria Louisa Henriëtte, De Becker, Ann, Mianulli, Anna Maria, Hackanson, Björn, Mihaylov, Georgi Georgiev, Martinelli, Giovanni, Paolini, Stefania, Zinzani, Pier Luigi, Henkes, Martin, Al-Ali, Haifa Kathrin, La Rosée, Paul, Chierichini, Anna, Cudillo, Laura, Specchia, Giorgina, Šimec, Njetočka Gredelj, Capalbo, Silvana Franca, Spinosa, Giuseppina, Molica, Stefano, de Jonge-Peeters, Susan Dorothé, Lübbert, Michael, Wijermans, Pierre W, Kicinski, Michal, Chantepie, Sylvain, Van der Velden, Walter J F M, Noppeney, Richard, Griškevičius, Laimonas, Neubauer, Andreas, Crysandt, Martina, Vrhovac, Radovan, Luppi, Mario, Fuhrmann, Stephan, Audisio, Ernesta, Candoni, Anna, Legrand, Olivier, Foà, Robin, Gaidano, Gianluca, van Lammeren-Venema, Danielle, Posthuma, Eduardus F M, Hoogendoorn, Mels, Giraut, Anne, Stevens-Kroef, Marian, Jansen, Joop H, de Graaf, Aniek O, Efficace, Fabio, Ammatuna, Emanuele, Vilque, Jean-Pierre, Wäsch, Ralph, Becker, Heiko, Blijlevens, Nicole, Dührsen, Ulrich, Baron, Frédéric, Suciu, Stefan, Amadori, Sergio, Venditti, Adriano, and Huls, Gerwin

Published
2023
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2. Prognostic and predictive performance of R-ISS with SKY92 in older patients with multiple myeloma: the HOVON-87/NMSG-18 trial

Author

Kuiper, Rowan, Zweegman, Sonja, van Duin, Mark, van Vliet, Martin H., van Beers, Erik H., Dumee, Belinda, Vermeulen, Michael, Koenders, Jasper, van der Holt, Bronno, Visser-Wisselaar, Heleen, Hansson, Markus, van der Velden, Annette W.G., Beverloo, H. Berna, Stevens-Kroef, Marian, Levin, Mark-David, Broijl, Annemiek, Waage, Anders, and Sonneveld, Pieter

Published
2020
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3. Genome Mapping Nomenclature.

Author

Moore, Sarah, McGowan-Jordan, Jean, Smith, Adam C., Rack, Katrina, Koehler, Udo, Stevens-Kroef, Marian, Barseghyan, Hayk, Kanagal-Shamanna, Rashmi, and Hastings, Ros

Subjects
GENE mapping, DNA copy number variations, MEDICAL personnel, PLANT gene mapping, GENETIC disorders, ANEUPLOIDY, CHROMOSOME abnormalities
Abstract

Background: Genome Mapping Technologies (optical and electronic) use ultra-high molecular weight DNA to detect structural variation and have application in constitutional genetic disorders, hematological neoplasms, and solid tumors. Genome mapping can detect balanced and unbalanced structural variation, copy number changes, and haplotypes. The technique is analogous to chromosomal microarray analysis, although genome mapping has the added benefit of being able to detect and ascertain the nature of more abnormalities in a single assay than array, karyotyping, or FISH alone. Key Messages: This paper describes a specific nomenclature for genome mapping that can be used by diagnostic and research centers to report their findings accurately. An international nomenclature is essential for patient results to be understood by different healthcare providers as well as for clear communication in publications and consistency in databases. Summary: Genome mapping can detect aneuploidy, balanced and unbalanced structural variation, as well as copy number changes. The Standing Committee for the International System for Human Cytogenomic Nomenclature (ISCN) recognised there was a need for a specific nomenclature for genome mapping that encompasses the range of abnormalities detected by this technique. This paper explains the general principles of the nomenclature as well as giving specific ISCN examples for the different types of numerical and structural rearrangements. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Similar efficacy outcomes with peripheral blood stem cell versus bone marrow for autologous stem cell transplantation in acute myeloid leukemia: Long‐term follow‐up of the EORTC‐GIMEMA randomized AML‐10 trial

Author

Baron, Frédéric, primary, Efficace, Fabio, additional, Cannella, Laura, additional, Stevens‐Kroef, Marian, additional, Amadori, Sergio, additional, de Witte, Theo, additional, Lübbert, Michael, additional, Venditti, Adriano, additional, and Suciu, Stefan, additional

Published
2024
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5. A framework for the clinical implementation of optical genome mapping in hematologic malignancies

Author

Levy, Brynn, primary, Kanagal‐Shamanna, Rashmi, additional, Sahajpal, Nikhil S., additional, Neveling, Kornelia, additional, Rack, Katrina, additional, Dewaele, Barbara, additional, Olde Weghuis, Daniel, additional, Stevens‐Kroef, Marian, additional, Puiggros, Anna, additional, Mallo, Mar, additional, Clifford, Benjamin, additional, Mantere, Tuomo, additional, Hoischen, Alexander, additional, Espinet, Blanca, additional, Kolhe, Ravindra, additional, Solé, Francesc, additional, Raca, Gordana, additional, and Smith, Adam C., additional

Published
2024
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7. Cytogenetic clonal heterogeneity is not an independent prognosis factor in 15–60-year-old AML patients: results on 1291 patients included in the EORTC/GIMEMA AML-10 and AML-12 trials

Author

Baron, Frédéric, Stevens-Kroef, Marian, Kicinski, Michal, Meloni, Giovanna, Muus, Petra, Marie, Jean-Pierre, Halkes, Constantijn J. M., Thomas, Xavier, Vrhovac, Radovan, Specchia, Giorgina, Lefrere, Sr, Francois, Sica, Simona, Mancini, Marco, Venditti, Adriano, Hagemeijer, Anne, Becker, Heiko, Jansen, Joop H., Amadori, Sergio, de Witte, Theo, Willemze, Roelof, and Suciu, Stefan

Published
2018
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8. Melphalan, prednisone, and lenalidomide versus melphalan, prednisone, and thalidomide in untreated multiple myeloma

Author

Zweegman, Sonja, van der Holt, Bronno, Mellqvist, Ulf-Henrik, Salomo, Morten, Bos, Gerard M.J., Levin, Mark-David, Visser-Wisselaar, Heleen, Hansson, Markus, van der Velden, Annette W.G., Deenik, Wendy, Gruber, Astrid, Coenen, Juleon L.L.M., Plesner, Torben, Klein, Saskia K., Tanis, Bea C., Szatkowski, Damian L., Brouwer, Rolf E., Westerman, Matthijs, Leys, M.(Rineke) B.L., Sinnige, Harm A.M., Haukås, Einar, van der Hem, Klaas G., Durian, Marc F., Mattijssen, E.(Vera)J.M., van de Donk, Niels W.C.J., Stevens-Kroef, Marian J.P.L., Sonneveld, Pieter, and Waage, Anders

Published
2016
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9. 10-day decitabine versus 3 + 7 chemotherapy followed by allografting in older patients with acute myeloid leukaemia: an open-label, randomised, controlled, phase 3 trial

Author

Lübbert, Michael, Wijermans, Pierre W, Kicinski, Michal, Chantepie, Sylvain, Van der Velden, Walter J F M, Noppeney, Richard, Griškevičius, Laimonas, Neubauer, Andreas, Crysandt, Martina, Vrhovac, Radovan, Luppi, Mario, Fuhrmann, Stephan, Audisio, Ernesta, Candoni, Anna, Legrand, Olivier, Foà, Robin, Gaidano, Gianluca, van Lammeren-Venema, Danielle, Posthuma, Eduardus F M, Hoogendoorn, Mels, Giraut, Anne, Stevens-Kroef, Marian, Jansen, Joop H, de Graaf, Aniek O, Efficace, Fabio, Ammatuna, Emanuele, Vilque, Jean-Pierre, Wäsch, Ralph, Becker, Heiko, Blijlevens, Nicole, Dührsen, Ulrich, Baron, Frédéric, Suciu, Stefan, Amadori, Sergio, Venditti, Adriano, Huls, Gerwin, Finke, Jürgen, Schaap, Nicolaas Petrus Michael, Zucenka, Andrius, Metzelder, Stephan, Jost, Edgar, Perić, Zinaida, Forghieri, Fabio, Allione, Bernadino, Martelli, Maurizio, Iori, Anna Paola, Wittnebel, Sebastian, Mengarelli, Andrea, Imovilli, Annalisa, Olivieri, Attilio, De Prijck, Bernard José Marie, van der Poel, Marjolein W.M., Junghanß, Christian, Salih, Helmut Rainer, Tafuri, Agostino, Guimarães, José Eduardo, Musso, Maurizio, De Fabritiis, Paolo, Chevallier, Patrice, Selleslag, Dominik Luc, Cascavilla, Nicola, Berneman, Zwi, Jaspers, Aurélie, Zuffa, Eliana, Vanstraelen, Gaëtan, Visani, Giuseppe, Cuijpers, Maria Louisa Henriëtte, De Becker, Ann, Mianulli, Anna Maria, Hackanson, Björn, Mihaylov, Georgi Georgiev, Martinelli, Giovanni, Paolini, Stefania, Zinzani, Pier Luigi, Henkes, Martin, Al-Ali, Haifa Kathrin, La Rosée, Paul, Chierichini, Anna, Cudillo, Laura, Specchia, Giorgina, Šimec, Njetočka Gredelj, Capalbo, Silvana Franca, Spinosa, Giuseppina, Molica, Stefano, and de Jonge-Peeters, Susan Dorothé

Abstract

Many older patients with acute myeloid leukaemia die or cannot undergo allogeneic haematopoietic stem-cell transplantation (HSCT) due to toxicity caused by intensive chemotherapy. We hypothesised that replacing intensive chemotherapy with decitabine monotherapy could improve outcomes.

Published
2023
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10. HER2, chromosome 17 polysomy and DNA ploidy status in breast cancer; a translational study

Author

Halilovic, Altuna, Verweij, Dagmar I., Simons, Annet, Stevens-Kroef, Marian J. P. L., Vermeulen, Susan, Elsink, Janet, Tops, Bastiaan B. J., Otte-Höller, Irene, van der Laak, Jeroen A. W. M., van de Water, Carlijn, Boelens, Oliver B. A., Schlooz-Vries, Margrethe S., Dijkstra, Jeroen R., Nagtegaal, Iris D., Tol, Jolien, van Cleef, Patricia H. J., Span, Paul N., and Bult, Peter

Published
2019
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12. Optical genome mapping enables constitutional chromosomal aberration detection

Author

Mantere, Tuomo, primary, Neveling, Kornelia, additional, Pebrel-Richard, Céline, additional, Benoist, Marion, additional, van der Zande, Guillaume, additional, Kater-Baats, Ellen, additional, Baatout, Imane, additional, van Beek, Ronald, additional, Yammine, Tony, additional, Oorsprong, Michiel, additional, Hsoumi, Faten, additional, Olde-Weghuis, Daniel, additional, Majdali, Wed, additional, Vermeulen, Susan, additional, Pauper, Marc, additional, Lebbar, Aziza, additional, Stevens-Kroef, Marian, additional, Sanlaville, Damien, additional, Dupont, Jean Michel, additional, Smeets, Dominique, additional, Hoischen, Alexander, additional, Schluth-Bolard, Caroline, additional, and El Khattabi, Laïla, additional

Published
2021
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13. Next-generation cytogenetics: Comprehensive assessment of 52 hematological malignancy genomes by optical genome mapping

Author

Neveling, Kornelia, primary, Mantere, Tuomo, additional, Vermeulen, Susan, additional, Oorsprong, Michiel, additional, van Beek, Ronald, additional, Kater-Baats, Ellen, additional, Pauper, Marc, additional, van der Zande, Guillaume, additional, Smeets, Dominique, additional, Weghuis, Daniel Olde, additional, Stevens-Kroef, Marian J.P.L., additional, and Hoischen, Alexander, additional

Published
2021
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14. Genomic arrays identify high-risk chronic lymphocytic leukemia with genomic complexity : a multicenter study

Author

Leeksma, Alexander C., Baliakas, Panagiotis, Moysiadis, Theodoros, Puiggros, Anna, Plevova, Karla, van der Kevie-Kersemaekers, Anne-Marie, Posthuma, Hidde, Rodriguez-Vicente, Ana E., Tran, Anh Nhi, Barbany, Gisela, Mansouri, Larry, Gunnarsson, Rebeqa, Parker, Helen, van den Berg, Eva, Bellido, Mar, Davis, Zadie, Wall, Meaghan, Scarpelli, Ilaria, Österborg, Anders, Hansson, Lotta, Jarosova, Marie, Ghia, Paolo, Poddighe, Pino, Espinet, Blanca, Pospisilova, Sarka, Tam, Constantine, Ysebaert, Loic, Nguyen-Khac, Florence, Oscier, David, Haferlach, Claudia, Schoumans, Jacqueline, Stevens-Kroef, Marian, Eldering, Eric, Stamatopoulos, Kostas, Rosenquist, Richard, Strefford, Jonathan C., Mellink, Clemens, Kater, Arnon P., Leeksma, Alexander C., Baliakas, Panagiotis, Moysiadis, Theodoros, Puiggros, Anna, Plevova, Karla, van der Kevie-Kersemaekers, Anne-Marie, Posthuma, Hidde, Rodriguez-Vicente, Ana E., Tran, Anh Nhi, Barbany, Gisela, Mansouri, Larry, Gunnarsson, Rebeqa, Parker, Helen, van den Berg, Eva, Bellido, Mar, Davis, Zadie, Wall, Meaghan, Scarpelli, Ilaria, Österborg, Anders, Hansson, Lotta, Jarosova, Marie, Ghia, Paolo, Poddighe, Pino, Espinet, Blanca, Pospisilova, Sarka, Tam, Constantine, Ysebaert, Loic, Nguyen-Khac, Florence, Oscier, David, Haferlach, Claudia, Schoumans, Jacqueline, Stevens-Kroef, Marian, Eldering, Eric, Stamatopoulos, Kostas, Rosenquist, Richard, Strefford, Jonathan C., Mellink, Clemens, and Kater, Arnon P.

Abstract

Complex karyotype identified by chromosome-banding analysis has been shown to have prognostic value in chronic lymphocytic leukemia (CLL). Genomic arrays offer high-resolution genomewide detection of copy-number alterations (CNA) and could therefore be well equipped to detect the presence of a complex karyotype. Current knowledge on genomic arrays in CLL is based on outcomes of single-cen ter studies, in which different cutoffs for CNA calling were used. To further determine the clinical utility of genomic arrays for CNA assessment in CLL diagnostics, we retrospectively analyzed 2,293 arrays from 13 diagnostic laboratories according to established standards. CNA were found outside regions captured by CLL fluorescence in situ hybridization probes in 34% of patients, and several of them, including gains of 8q, deletions of 9p and 18p (P<0.01), were linked to poor outcome after correction for multiple testing. Patients (n=972) could be divided into three distinct prognostic subgroups based on the number of CNA. In multivariable analysis only high genomic complexity, defined as z5 CNA, emerged as an independent adverse prognosticator for time to first treatment (hazard ratio: 2.15; 95% confidence interval: 1.36-3.41; P=0.001) and overall survival (hazard ratio: 2.54, 95% confidence interval: 1.54-4.17; P<0.001; n=528). Lowering the size cutoff to 1 Mb in 647 patients did not significantly improve risk assessment. Genomic arrays detected more chromosomal abnormalities and, in terms of risk stratification, performed at least as well as simultaneous chromosome banding analysis as carried out in 122 patients. Our findings indicate that genomic array is an accurate tool for CLL risk stratification.

Published
2021
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15. Optical genome mapping enables constitutional chromosomal aberration detection: proof-of-principle study with 85 samples

Author

Mantere, Tuomo, primary, Neveling, Kornelia, additional, Richard, Céline, additional, Benoist, Marion, additional, van der Zande, Guillaume, additional, Kater-Baats, Ellen, additional, Baatout, Imane, additional, van Beek, Ronald, additional, Yammine, Tony, additional, Oorsprong, Michiel, additional, Olde-Weghuis, Daniel, additional, Majdali, Wed, additional, Vermeulen, Susan, additional, Pauper, Marc, additional, Lebbar, Aziza, additional, Stevens-Kroef, Marian, additional, Sanlaville, Damien, additional, Smeets, Dominique, additional, Dupont, Jean-Michel, additional, Hoischen, Alexander, additional, Schluth-Bolard, Caroline, additional, and El Khattabi, Laïla, additional

Published
2021
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16. Genomic arrays identify high-risk chronic lymphocytic leukemia with genomic complexity: a multi-center study

Author

Leeksma, Alexander C., Baliakas, Panagiotis, Moysiadis, Theodoros, Puiggros, Anna, Plevova, Karla, Van der Kevie-Kersemaekers, Anne-Marie, Posthuma, Hidde, Rodriguez-Vicente, Ana E., Tran, Anh Nhi, Barbany, Gisela, Mansouri, Larry, Gunnarsson, Rebeqa, Parker, Helen, Van den Berg, Eva, Bellido, Mar, Davis, Zadie, Wall, Meaghan, Scarpelli, Ilaria, Österborg, Anders, Hansson, Lotta, Jarosova, Marie, Ghia, Paolo, Poddighe, Pino, Espinet, Blanca, Pospisilova, Sarka, Tam, Constantine, Ysebaert, Loïc, Nguyen-Khac, Florence, Oscier, David, Haferlach, Claudia, Schoumans, Jacqueline, Stevens-Kroef, Marian, Eldering, Eric, Stamatopoulos, Kostas, Rosenquist, Richard, Jonathan C. Strefford, undefined, Mellink, Clemens, Kater, Arnon P., Leeksma, Alexander C., Baliakas, Panagiotis, Moysiadis, Theodoros, Puiggros, Anna, Plevova, Karla, Van der Kevie-Kersemaekers, Anne-Marie, Posthuma, Hidde, Rodriguez-Vicente, Ana E., Tran, Anh Nhi, Barbany, Gisela, Mansouri, Larry, Gunnarsson, Rebeqa, Parker, Helen, Van den Berg, Eva, Bellido, Mar, Davis, Zadie, Wall, Meaghan, Scarpelli, Ilaria, Österborg, Anders, Hansson, Lotta, Jarosova, Marie, Ghia, Paolo, Poddighe, Pino, Espinet, Blanca, Pospisilova, Sarka, Tam, Constantine, Ysebaert, Loïc, Nguyen-Khac, Florence, Oscier, David, Haferlach, Claudia, Schoumans, Jacqueline, Stevens-Kroef, Marian, Eldering, Eric, Stamatopoulos, Kostas, Rosenquist, Richard, Jonathan C. Strefford, undefined, Mellink, Clemens, and Kater, Arnon P.

Published
2020
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17. Survival Improvement over Time of 960 s-AML Patients Included in 13 EORTC-GIMEMA-HOVON Trials

Author

Ramadan, Safaa M., primary, Suciu, Stefan, additional, Stevens-Kroef, Marian J. P. L., additional, Willemze, Roelof, additional, Amadori, Sergio, additional, de Witte, Theo, additional, Löwenberg, Bob, additional, Muus, Petra, additional, Labar, Boris, additional, Meert, Liv, additional, de Schaetzen, Gaetan, additional, Meloni, Giovanna, additional, Leone, Giuseppe, additional, Vignetti, Marco, additional, Marie, Jean-Pierre, additional, Lübbert, Michael, additional, and Baron, Frédéric, additional

Published
2020
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18. Next generation cytogenetics: genome-imaging enables comprehensive structural variant detection for 100 constitutional chromosomal aberrations in 85 samples

Author

Mantere, Tuomo, primary, Neveling, Kornelia, additional, Pebrel-Richard, Céline, additional, Benoist, Marion, additional, van der Zande, Guillaume, additional, Kater-Baats, Ellen, additional, Baatout, Imane, additional, van Beek, Ronald, additional, Yammine, Tony, additional, Oorsprong, Michiel, additional, Olde-Weghuis, Daniel, additional, Majdali, Wed, additional, Vermeulen, Susan, additional, Pauper, Marc, additional, Lebbar, Aziza, additional, Stevens-Kroef, Marian, additional, Sanlaville, Damien, additional, Smeets, Dominique, additional, Dupont, Jean Michel, additional, Hoischen, Alexander, additional, Schluth-Bolard, Caroline, additional, and El Khattabi, Laïla, additional

Published
2020
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19. Impact of the type of anthracycline and of stem cell transplantation in younger patients with acute myeloid leukaemia: Long‐term follow up of a phase III study

Author

Baron, Frédéric, primary, Efficace, Fabio, additional, Cannella, Laura, additional, Muus, Petra, additional, Trisolini, Silvia, additional, Halkes, Constantijn J. M., additional, Fazi, Paola, additional, Vignetti, Marco, additional, Marie, Jean‐Pierre, additional, Chiusolo, Patrizia, additional, van der Velden, Walter, additional, La Sala, Edoardo, additional, Vitolo, Umberto, additional, Thomas, Xavier, additional, Lefrère, Francois, additional, Di Raimondo, Francesco, additional, Bourhis, Jean‐Henri, additional, Specchia, Giorgina, additional, Guimarães, José E., additional, Allione, Bernardino, additional, Vrhovac, Radovan, additional, Ferrara, Felicetto, additional, Stevens‐Kroef, Marian, additional, Meert, Liv, additional, de Witte, Theo, additional, Willemze, Roelof, additional, Amadori, Sergio, additional, and Suciu, Stefan, additional

Published
2020
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20. Next generation cytogenetics: comprehensive assessment of 48 leukemia genomes by genome imaging

Author

Neveling, Kornelia, primary, Mantere, Tuomo, additional, Vermeulen, Susan, additional, Oorsprong, Michiel, additional, van Beek, Ronald, additional, Kater-Baats, Ellen, additional, Pauper, Marc, additional, van der Zande, Guillaume, additional, Smeets, Dominique, additional, Weghuis, Daniel Olde, additional, Stevens-Kroef, Marian J, additional, and Hoischen, Alexander, additional

Published
2020
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21. Bortezomib-Based Induction and Maintenance Overcomes the Negative Prognostic Impact of Renal Impairment and del17p in Transplant-Eligible Myeloma Patients: Long Term Results from the Phase III HOVON-65/GMMG-HD4 Study after Median 137 Months Follow up

Author

Scheid, Christof, primary, Lokhorst, Henk, additional, Blau, Igor W, additional, Van Der Holt, Bronno, additional, Bertsch, Uta, additional, Zweegman, Sonja, additional, Weisel, Katja, additional, Vellenga, Edo, additional, Kersten, Marie José, additional, Croockewit, Sandra, additional, Mai, Elias K, additional, Raymakers, Reinier, additional, Hose, Dirk, additional, Jauch, Anna, additional, Hillengass, Jens, additional, Stevens-Kroef, Marian, additional, Raab, Marc S, additional, Neben, Kai, additional, Stilgenbauer, Stephan, additional, Broyl, Annemiek, additional, Lindemann, Hans-Walter, additional, Bos, Gerard, additional, Brossart, Peter, additional, van Marwijk Kooij, Marinus, additional, Ypma, Paula F, additional, Dührsen, Ulrich, additional, Schaafsma, Ron, additional, Hielscher, Thomas, additional, Salwender, Hans, additional, Goldschmidt, Hartmut, additional, and Sonneveld, Pieter, additional

Published
2019
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22. Prognostic and Predictive Performance of SKY92 Combined with R-ISS in Elderly Multiple Myeloma Patients in The Hovon-87/NMSG-18 Study

Author

Kuiper, Rowan, primary, Broijl, Annemiek, additional, van Duin, Mark, additional, van Vliet, Martin H., additional, Levin, Mark-David, additional, van Beers, Erik H., additional, Van der Holt, Bronno, additional, Visser, Heleen, additional, Hansson, Markus, additional, van der Velden, Annette W.G., additional, Dumee, Belinda, additional, Vermeulen, Michael, additional, Koenders, Jasper, additional, Beverloo, H. Berna, additional, Stevens-Kroef, Marian, additional, Sonneveld, Pieter, additional, Waage, Anders, additional, and Zweegman, Sonja, additional

Published
2019
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23. Impact of induction regimen and allogeneic hematopoietic cell transplantation on outcome in younger adults with acute myeloid leukemia with a monosomal karyotype

Author

Baron, Frédéric, primary, Stevens-Kroef, Marian, additional, Kicinski, Michal, additional, Meloni, Giovanna, additional, Muus, Petra, additional, Marie, Jean-Pierre, additional, Halkes, Constantijn J.M., additional, Thomas, Xavier, additional, Vrhovac, Radovan, additional, Albano, Francesco, additional, Lefrère, François, additional, Sica, Simona, additional, Mancini, Marco, additional, Venditti, Adriano, additional, Hagemeijer, Anne, additional, Jansen, Joop H., additional, Amadori, Sergio, additional, de Witte, Theo, additional, Willemze, Roelof, additional, and Suciu, Stefan, additional

Published
2018
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24. Ixazomib-Thalidomide-Low Dose Dexamethasone (ITd) Induction Followed By Maintenance Therapy with Ixazomib or Placebo in Newly Diagnosed Multiple Myeloma Patients Not Eligible for Autologous Stem Cell Transplantation; Results from the Randomized Phase II HOVON-126/Nmsg 21#13 Trial

Author

Zweegman, Sonja, primary, Schjesvold, Fredrik H., additional, van der Holt, Bronno, additional, Levin, Mark-David, additional, Stege, Claudia A.M., additional, Waage, Anders, additional, Leijs, Maria B.L., additional, Klein, Saskia K., additional, Szatkowski, Damian L., additional, Axelsson, Per, additional, Hieu Do, Trung, additional, Knut-Bojanovska, Dorota, additional, van der Spek, Ellen, additional, Svirskaite, Asta, additional, Poddighe, Pino, additional, Stevens-Kroef, Marian, additional, Hansson, Markus, additional, van de Donk, Niels WCJ, additional, Haukas, Einar, additional, Sonneveld, Pieter, additional, and Abildgaard, Niels, additional

Published
2018
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25. Impact of Induction Regimen and of Allogeneic Hematopoietic Cell Transplantation on Outcome in Younger Adults Patients with Acute Myeloid Leukemia with a Monosomal Karyotype

Author

Baron, Frédéric, Stevens-Kroef, Marian, Kicinski, Michal, Meloni, Giovanna, Muus, Petra, Marie, Jean-Pierre, Halkes, Constantijn J M, Thomas, Xavier, Vrhovac, Radovan, Albano, Francesco, Lefrère, Françoi, Sica, Simona, Mancini, Marco, Venditti, Adriano, Hagemeijer, Anne, Jansen, Joop H, Amadori, Sergio, de Witte, Theo, Willemze, Reol, Suciu, Stefan, Sica, Simona (ORCID:0000-0003-2426-3465), Baron, Frédéric, Stevens-Kroef, Marian, Kicinski, Michal, Meloni, Giovanna, Muus, Petra, Marie, Jean-Pierre, Halkes, Constantijn J M, Thomas, Xavier, Vrhovac, Radovan, Albano, Francesco, Lefrère, Françoi, Sica, Simona, Mancini, Marco, Venditti, Adriano, Hagemeijer, Anne, Jansen, Joop H, Amadori, Sergio, de Witte, Theo, Willemze, Reol, Suciu, Stefan, and Sica, Simona (ORCID:0000-0003-2426-3465)

Abstract

Monosomal karyotype (MK) confers a poor prognosis in patients with acute myeloid leukemia (AML). Here, we determined the impact of the type of remission-induction chemotherapy and the impact of having a donor in younger AML patients with a MK included in two phase III trials. In the first trial, patients were randomized to receive either daunorubicin (DNR), mitoxantrone (MTX), or idarubicin (IDA) in addition to standard-dose cytarabine (SDAC) and etoposide for induction chemotherapy. In the second trial, patients were randomized between either SDAC or high dose cytarabine (HiDAC) induction, both with DNR and etoposide. In both trials, patients who achieved a complete remission with (CR) or without (CRi) complete hematological recovery received an allogeneic hematopoietic stem cell transplantation (allo-HSCT) if they had a donor or an autologous HSCT (auto-HSCT) otherwise. In comparison to patients with intermediate risk cytogenetics without MK (n=1584) and with adverse cytogenetics without MK (n=218), MK+ patients (n=188) were more likely not to achieve a CR/CRi (odds ratio=2.85, 95% confidence interval, CI: 2.10-3.88) and had shorter overall survival (OS) (hazard ratio, HR=2.44, 95% CI: 2.08-2.88) and OS from CR/CRi (HR=2.73, 95% CI: 2.17-3.45). There was no impact of the type of anthracycline or of SDAC vs HiDAC on outcomes in MK+ patients. Among MK+ patients who achieved a CR/CRi, HLA-identical related donor availability was associated with longer survival from CR/CRi (HR=0.59, 95% CI: 0.37-0.95). In summary, these data suggest no benefit of HiDAC in MK+ patients but better OS associated with allo-HSCT.

Published
2018

26. Quality of life with melphalan/prednisone plus either thalidomide (MPT-T) or lenalidomide (MPR-R) in non-transplant eligible newly diagnosed multiple myeloma:results of the HOVON87/NMSG18 study

Author

Stege, Claudia A.M., Kongsgaard Nielsen, Lene, Witte, Birgit, van der Holt, Bronno, Mellqvist, Ulf-Henrik, Salomo, Morten, Bos, Gerard, Levin, Mark-David, Visser-Wisselaar, Heleen, Hansson, Markus, van der Velden, Annette, Deenik, Wendy, Gruber, Astrid, Coenen, Juleon, Plesner, Torben, Klein, Saskia, Tanis, Bea, Szatkowski, Damian L., Brouwer, Rolf, Westerman, Matthijs, Leys, Rineke, Sinnige, Harm, Haukås, Einar, van der Hem, Klaas, Durian, Marc, Mattijssen, Vera, Gimsing, Peter, van de Donk, Niels, Stevens-Kroef, Marian, Sonneveld, Pieter, Waage, Anders, Zweegman, Sonja, and Abildgaard , Niels

Published
2017

29. Guidelines for genomic array analysis in acquired haematological neoplastic disorders

Author

Schoumans, Jacqueline, Suela, Javier, Hastings, Ros, Muehlematter, Dominique, Rack, Katrina, van den Berg, Eva, Beverloo, H. Berna, Stevens-Kroef, Marian, and Clinical Genetics

Subjects
COPY NUMBER ABNORMALITIES, CHRONIC LYMPHOCYTIC-LEUKEMIA, MULTIPLE-MYELOMA, B-CELL PRECURSOR, PROGNOSTIC-SIGNIFICANCE, MYELODYSPLASTIC SYNDROMES, MICROARRAY ANALYSIS, Tumours of the digestive tract Radboud Institute for Molecular Life Sciences [Radboudumc 14], IKZF1 DELETION, CHROMOSOME-ABNORMALITIES, ACUTE LYMPHOBLASTIC-LEUKEMIA
Abstract

Item does not contain fulltext Genetic profiling is important for disease evaluation and prediction of prognosis or responsiveness to therapy in neoplasia. Microarray technologies, including array comparative genomic hybridization and single-nucleotide polymorphism-detecting arrays, have in recent years been introduced into the diagnostic setting for specific types of haematological malignancies and solid tumours. It can be used as a complementary test or depending on the neoplasia investigated, also as a standalone test. However, comprehensive and readable presentation of frequently identified complex genomic profiles remains challenging. To assist diagnostic laboratories, standardization and minimum criteria for clinical interpretation and reporting of acquired genomic abnormalities detected through arrays in neoplastic disorders are presented. (c) 2016 Wiley Periodicals, Inc.

Published
2016

30. Impact of Induction Regimen and of Allogeneic Hematopoietic Cell Transplantation on the Outcome in Younger Adults Patients with Acute Myeloid Leukemia with a Monosomal Karyotype: Results from the EORTC/Gimema AML-10 and AML-12 Trials

Author

Baron, Frederic, Stevens-Kroef, Marian, Meloni, Giovanna, Muus, Petra, Marie, Jean-Pierre, Halkes, Constantijn, Thomas, Xavier, Vrhovac, Radovan, Specchia, Giorgina, Lefrere, Francois, Sica, Simona, Mancini, Marco, Venditti, Adriano, Hagemeijer, Anne, H. Jansen, Joop, Amadori, Sergio, de Witte, Theo, Willemze, Roelof, Suciu, and Stefan Suciu

Subjects
Acute Myeloid Leukemia: Biology, Cytogenetics, and Molecular Markers in Diagnosis and Prognosis
Abstract

Background. Previous studies have demonstrated that monosomal karyotype (MK) confers a particularly poor prognosis in patients with acute myeloid leukemia (AML) (Breems et al., J Clin Oncol 2008, 26:4791-7). Purpose of the study. To determine the impact of the type of remission- induction chemotherapy and the impact of having a donor on overall survival (OS) in younger (

Published
2016

31. Clonal evolution in myelodysplastic syndromes

Author

da Silva-Coelho, Pedro, primary, Kroeze, Leonie I., additional, Yoshida, Kenichi, additional, Koorenhof-Scheele, Theresia N., additional, Knops, Ruth, additional, van de Locht, Louis T., additional, de Graaf, Aniek O., additional, Massop, Marion, additional, Sandmann, Sarah, additional, Dugas, Martin, additional, Stevens-Kroef, Marian J., additional, Cermak, Jaroslav, additional, Shiraishi, Yuichi, additional, Chiba, Kenichi, additional, Tanaka, Hiroko, additional, Miyano, Satoru, additional, de Witte, Theo, additional, Blijlevens, Nicole M. A., additional, Muus, Petra, additional, Huls, Gerwin, additional, van der Reijden, Bert A., additional, Ogawa, Seishi, additional, and Jansen, Joop H., additional

Published
2017
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32. Genomic array as compared to karyotyping in myelodysplastic syndromes in a prospective clinical trial

Author

Stevens‐Kroef, Marian J., primary, Olde Weghuis, Daniel, additional, ElIdrissi‐Zaynoun, Najat, additional, van der Reijden, Bert, additional, Cremers, Eline M. P., additional, Alhan, Canan, additional, Westers, Theresia M., additional, Visser‐Wisselaar, Heleen A., additional, Chitu, Dana A., additional, Cunha, Sonia M., additional, Vellenga, Edo, additional, Klein, Saskia K., additional, Wijermans, Pierre, additional, de Greef, Georgine E., additional, Schaafsma, M. Ron, additional, Muus, Petra, additional, Ossenkoppele, Gert J., additional, van de Loosdrecht, Arjan A., additional, and Jansen, Joop H., additional

Published
2017
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33. Impact of Induction Regimen and of Allogeneic Hematopoietic Cell Transplantation on the Outcome in Younger Adults Patients with Acute Myeloid Leukemia with a Monosomal Karyotype: Results from the EORTC/Gimema AML-10 and AML-12 Trials

Author

Baron, Frederic, primary, Stevens-Kroef, Marian, additional, Meloni, Giovanna, additional, Muus, Petra, additional, Marie, Jean-Pierre, additional, Halkes, Constantijn J.M., additional, Thomas, Xavier, additional, Vrhovac, Radovan, additional, Specchia, Giorgina, additional, Lefrere, Francois, additional, Sica, Simona, additional, Mancini, Marco, additional, Venditti, Adriano, additional, Hagemeijer, Anne, additional, Jansen, Joop H., additional, Amadori, Sergio, additional, de Witte, Theo, additional, Willemze, Roelof, additional, and Suciu, Stefan, additional

Published
2016
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35. Implementation of erythroid lineage analysis by flow cytometry in diagnostic models for myelodysplastic syndromes

Author

Cremers, Eline M.P., primary, Westers, Theresia M., additional, Alhan, Canan, additional, Cali, Claudia, additional, Visser-Wisselaar, Heleen A., additional, Chitu, Dana A., additional, van der Velden, Vincent H.J., additional, te Marvelde, Jeroen G., additional, Klein, Saskia K., additional, Muus, Petra, additional, Vellenga, Edo, additional, de Greef, Georgina E., additional, Legdeur, Marie-Cecile C.J.C., additional, Wijermans, Pierre W., additional, Stevens-Kroef, Marian J.P.L., additional, Silva-Coelho, Pedro da, additional, Jansen, Joop H., additional, Ossenkoppele, Gert J., additional, and van de Loosdrecht, Arjan A., additional

Published
2016
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36. Phase I/II trial of weekly bortezomib with lenalidomide and dexamethasone in first relapse or primary refractory myeloma

Author

Broijl, Annemiek, primary, Kersten, Marie-José, additional, Alemayehu, Wendimagegn Ghidey, additional, Levin, Mark-David, additional, de Weerdt, Okke, additional, Vellenga, Edo, additional, Meijer, Ellen, additional, Wittebol, Shulamit, additional, Tanis, Bea C., additional, Cornelisse, Petra B., additional, Stevens-Kroef, Marian, additional, Bos, Gerard M.J., additional, Wijermans, Pierre W., additional, Lokhorst, Henk, additional, and Sonneveld, Pieter, additional

Published
2015
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37. Validation of the EMC92/SKY92 Signature in HOVON-87/Nmsg-18: Gene Expression Based Prognostication Is Applicable in Elderly Patients with Newly Diagnosed Multiple Myeloma

Author

van Duin, Mark, primary, Kuiper, Rowan, additional, van Vliet, Martin, additional, Broijl, Annemiek, additional, de Best, Leonie, additional, van Beers, Erik, additional, Van Der Holt, Bronno, additional, Visser-Wisselaar, Heleen, additional, Bosman, Lizanne, additional, Dumee, Belinda, additional, van den Bosch, Fanni, additional, Vermeulen, Michael, additional, Koenders, Jasper, additional, Stevens-Kroef, Marian, additional, Waage, Anders, additional, Zweegman, Sonja, additional, and Sonneveld, Pieter, additional

Published
2015
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38. The Impact of Cytogenetic Clonality on Outcomes in Younger Acute Myeloid Leukemia Patients: Results on 1290 Patients Included in the EORTC/Gimema AML-10 and AML-12 Trials

Author

Baron, Frederic, Stevens-Kroef, Marian, Kicinski, Michal, Meloni, Giovanna, Muus, Petra, Marie, Jean-Pierre, Halkes, Constantijn J.M., Thomas, Xavier, Vrhovac, Radovan, Pasciolla, Crescenza, Lefrere, Francois, Sr., Sica, Simona, Mancini, Marco, Venditti, Adriano, Hagemeijer, Anne, Becker, Heiko, Jansen, Joop H., Amadori, Sergio, de Witte, T. M. M, Willemze, Roelof, and Suciu, Stefan

Published
2017
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40. Guidelines for cytogenetic investigations in tumours

Author

Hastings, Rosalind J, primary, Bown, Nick, additional, Tibiletti, Maria G, additional, Debiec-Rychter, Maria, additional, Vanni, Roberta, additional, Espinet, Blanca, additional, van Roy, Nadine, additional, Roberts, Paul, additional, van den Berg-de-Ruiter, Eva, additional, Bernheim, Alain, additional, Schoumans, Jacqueline, additional, Chatters, Steve, additional, Zemanova, Zuzana, additional, Stevens-Kroef, Marian, additional, Simons, Annet, additional, Heim, Sverre, additional, Salido, Marta, additional, Ylstra, Bauke, additional, and Betts, David R, additional

Published
2015
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42. Erythroid Lineage Analysis By Flow Cytometry Is of Highly Additive Value for MDS Diagnosis: A Study on Behalf of the HOVON89 Study Group

Author

Cremers, Eline MP, primary, Westers, Theresia M, additional, Alhan, Canan, additional, Cali, Claudia, additional, Visser-Wisselaar, Heleen A, additional, Chitu, Dana A, additional, Stevens-Kroef, Marian JPL, additional, Silva Coelho, Pedro, additional, Vellenga, Edo, additional, Klein, Saskia K., additional, Wijermans, Pierre W., additional, De Greef, Georgine E, additional, Legdeur, Marie-Cecile, additional, Muus, Petra, additional, Ossenkoppele, Gert J, additional, Jansen, Joop H, additional, and Van de Loosdrecht, Arjan A, additional

Published
2014
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43. Phase I/II Trial of Weekly Escalated Dose Bortezomib Combined with Lenalidomide and Dexamethasone in Patients in First Relapse or Primary Refractory Disease after First Line Therapy for Multiple Myeloma

Author

Broijl, Annemiek, primary, Kersten, Marie José, additional, Ghidey Alemayehu, Wendim, additional, Levin, Mark-David, additional, de Weerdt, Okke, additional, Vellenga, Edo, additional, Meijer, Ellen, additional, Wittebol, Shulamiet, additional, Ghiraw-Visser, Rosita, additional, Stevens-Kroef, Marian, additional, Beverloo, Berna, additional, Bos, Gerard M.J., additional, Wijermans, Pierre W., additional, Lokhorst, Henk, additional, and Sonneveld, Pieter, additional

Published
2014
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44. Randomized Phase III Trial in Non-Transplant Eligible Patients with Newly Diagnosed Symptomatic Multiple Myeloma Comparing Melphalan-Prednisone-Thalidomide Followed By Thalidomide Maintenance (MPT-T) Versus Melphalan-Prednisone-Lenalidomide Followed By Maintenance with Lenalidomide (MPR-R); A Joint Study of the Dutch-Belgian Cooperative Trial Group for Hematology Oncology (HOVON) and the Nordic Myeloma Study Group (NMSG)

Author

Zweegman, Sonja, primary, Holt, Bronno van der, additional, Mellqvist, Ulf-Henrik, additional, Salomo, Morten, additional, Bos, Gerard M.J., additional, Levin, Mark-David, additional, Visser-Wisselaar, Heleen A, additional, Hansson, Markus, additional, van der Velden, Annette WG, additional, Deenik, Wendy, additional, Gruber, Astrid, additional, Coenen, Juleon LLM, additional, Plesner, Torben, additional, Klein, Saskia K, additional, Tanis, Bea, additional, Szatkowski, Damian L, additional, Brouwer, Rolf, additional, Westerman, Matthijs, additional, Leys, M (Rineke) BL, additional, van de Donk, Niels W.C.J., additional, Haukås, Einar, additional, van der Hem, Klaas, additional, Durian, MF, additional, Mattijssen, E (Vera) JM, additional, Sinnige, Harm AM, additional, Stevens-Kroef, Marian JPL, additional, Sonneveld, Pieter, additional, and Waage, Anders, additional

Published
2014
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45. Guidelines for cytogenetic investigations in tumours

Author

Hastings, Rosalind J, Bown, Nick, Tibiletti, Maria G, Debiec-Rychter, Maria, Vanni, Roberta, Espinet, Blanca, van Roy, Nadine, Roberts, Paul, van den Berg-de-Ruiter, Eva, Bernheim, Alain, Schoumans, Jacqueline, Chatters, Steve, Zemanova, Zuzana, Stevens-Kroef, Marian, Simons, Annet, Heim, Sverre, Salido, Marta, Ylstra, Bauke, and Betts, David R

Published
2016
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46. Genomic Complexity in Chronic Lymphocytic Leukemia Defined By Array-Based Analysis: Definitions, Associations with Other Biomarkers and Clinical Impact

Author

Leeksma, Alexander, Baliakas, Panagiotis, Mellink, Clemens, Moysiadis, Theodoros, Puiggros, Anna, Plevova, Karla, van den Berg, Eva, Eldering, Eric, Skaftason, Aron, Mansouri, Larry, Gunnarsson, Rebeqa, Ghia, Paolo, Espinet, Blanca, Pospisilova, Sarka, Nguyen-Khac, Florence, Oscier, David, Stamatopoulos, Kostas, Haferlach, Claudia, Rosenquist, Richard, Strefford, Jonathan C, Stevens-Kroef, Marian, and Kater, Arnon P.

Abstract

Background:The advent of efficacious but also very expensive novel treatment regimens for high-risk chronic lymphocytic leukemia (CLL), has highlighted the need for accurate risk-stratification. Published evidence indicates that classic chromosome banding analysis (CBA) offers valuable complementary information to the routinely performed FISH analysis in CLL, potentially improving risk assessment. Indeed, recent studies identified complex karyotype (CK; defined as ≥3 abberations) as an independent predictive marker for refractoriness to ibrutinib and venetoclax, although for CLL, a precise evidence-based definition of genomic complexity (GC) is yet to be made. Array-based (CGH/SNP) analysis is capable of globally assessing the CLL genome, does not require in vitro mitogens, offers increased detection depth, and allows for easier standardization.

Published
2017
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47. Impact of the Type of Anthracycline and of Allogeneic Stem Cell Transplantation in the Treatment of Younger Acute Myeloid Leukemia Patients: Long-Term Follow-up of the EORTC-Gimema AML-10 Trial

Author

Baron, Frederic, Efficace, Fabio, Cannella, Laura, Mandelli, Franco, Muus, Petra, Trisolini, Silvia Maria, Halkes, Constantijn J.M., Fazi, Paola, Vignetti, Marco, Marie, Jean-Pierre, Chiusolo, Patrizia, Van Der Velden, Walter JFM, La Sala, Edoardo, Vitolo, Umberto, Thomas, Xavier, Lefrere, Francois, Di Raimondo, Francesco, Bourhis, Jean-Henri, Specchia, Giorgina, Guimaraes, Jose E., Allione, Bernardino, Vrhovac, Radovan, Ferrara, Felicetto, Stevens-Kroef, Marian, Willemze, Roelof, Amadori, Sergio, de Witte, Theo, and Suciu, Stefan

Abstract

FB, FE and SS contributed equally to the work.

Published
2017
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48. Frailty Predicts Survival and Toxicity in Newly Diagnosed Multiple Myeloma Patients Ineligible for Autologous Stem Cell Transplantation; Report of the HOVON-87/Nmsg-18 Study Group

Author

Stege, Claudia A.M., van der Holt, Bronno, Mellqvist, Ulf-Henrik, Levin, Mark-David, Salomo, Morten, Abildgaard, Niels, Bos, Gerard, Visser-Wisselaar, Heleen, Hansson, Markus, van der Velden, Annette, Deenik, Wendy, Gruber, Astrid, Coenen, Jules L.L.M., Plesner, Torben, Klein, Saskia, Tanis, Bea, Szatkowski, Damian L., Brouwer, Rolf, Westerman, Matthijs, Leijs, Maria Berhardina, Sinnige, Harm, Haukaas, Einar, van der Hem, Klaas, Durian, Marc, Mattijssen, Vera, Gimsing, Peter, Van De Donk, Niels WCJ, Stevens-Kroef, Marian, Sonneveld, Pieter, Waage, Anders, and Zweegman, Sonja

Abstract

Introduction

Published
2017
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49. Paired Analyses of Diagnostic and Relapse Samples of MLLrearranged Infant Acute Lymphoblastic Leukemia Reveals Potential Therapy-Resistant Genomic Alterations

Author

Buijs, Arjan, Stevens-Kroef, Marian JPL, Sonneveld, Edwin, and van der Veken, Lars T.

Abstract

Infant acute lymphoblastic leukemia (ALL) (less than one-year-old) is a rare, aggressive disease, with unique biological and clinical features. It is associated with 11q23 MLLrearrangements (MLL-R), and a high relapse risk. In contrast, in childhood ALL (age 1-18 years) the majority survives beyond 5 years, and only 15-20% of patients relapse. The genomic landscape in the latter group has been investigated quite extensively, and is has proven to be of diagnostic and prognostic significance. Paired diagnostic and relapse samples have identified frequent microdeletions in B-cell differentiation and cell cycle regulating genes IKZF1, EBF1and CDKN2A/B. Alterations in these genes, either at diagnosis or relapse are linked to therapy-resistance. In contrast, data on copy-number alterations in infant ALL, particularly at relapse, are very limited. Therefore, we investigated two infant ALL at diagnosis and relapse by molecular cytogenetic analyses including high-density SNP array.

Published
2014
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50. eP406 - Optical genome mapping enables constitutional chromosomal aberration detection: proof-of-principle study with 85 samples.

Author

Mantere, Tuomo, Neveling, Kornelia, Richard, Céline, Benoist, Marion, van der Zande, Guillaume, Kater-Baats, Ellen, Baatout, Imane, van Beek, Ronald, Yammine, Tony, Oorsprong, Michiel, Olde-Weghuis, Daniel, Majdali, Wed, Vermeulen, Susan, Pauper, Marc, Lebbar, Aziza, Stevens-Kroef, Marian, Sanlaville, Damien, Smeets, Dominique, Dupont, Jean-Michel, and Hoischen, Alexander

Subjects
*GENE mapping, *CHROMOSOME abnormalities
Published
2021
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