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263 results on '"Stegeman, Coen A"'

4. Targeting NF-κB signaling in B cells as a potential new treatment modality for ANCA-associated vasculitis

Author

Merino-Vico, Ana, van Hamburg, Jan Piet, Tuijnenburg, Paul, Frazzei, Giulia, Al-Soudi, Aram, Bonasia, Carlo G., Helder, Boy, Rutgers, Abraham, Abdulahad, Wayel H., Stegeman, Coen A., Sanders, Jan-Stephan, Bergamaschi, Laura, Lyons, Paul A., Bijma, Theo, van Keep, Laura, Wesenhagen, Kirsten, Jongejan, Aldo, Olsson, Henric, de Vries, Niek, Kuijpers, Taco W., Heeringa, Peter, and Tas, Sander W.

Published
2024
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7. Clinical usefulness of urine Gram stain for diagnosing urinary tract infections at the emergency department.

Author

Middelkoop, Stephanie J. M., de Joode, Anoek A. E., van Pelt, L. Joost, Kampinga, Greetje A., ter Maaten, Jan C., and Stegeman, Coen A.

Subjects
GRAM'S stain, GRAM-negative bacteria, GRAM-positive bacteria, URINALYSIS, URINARY tract infections, EMERGENCY medicine
Abstract

Background: Diagnosis of urinary tract infections (UTIs) is a frequent challenge at the emergency department (ED). The clinical usefulness of the urine Gram stain (GS) is uncertain. Objective: We studied the GS performance to clarify its clinical utility at the ED. Methods: Urine dipstick (UD), automated urinalysis (UF-1000i), GS and urine culture (UC) were performed in a cohort of consecutive adults presenting at the ED suspected of a UTI. GS performance was assessed and compared to UD and UF-1000i. Results: A UTI diagnosis was established in 487/1358 (35.9%) episodes. Sensitivity and specificity for 'many' GS leucocytes was 33.7% and 95.4%; for 'many' GS bacteria 51.3% and 91.0%. GS diagnostic performance by ROC analysis was 0.796 for leucocytes and 0.823 for bacteria. GS bacteria performed better than UD nitrite comparable to UF-1000i bacteria. GS leucocytes underperformed compared to UD leucocyte esterase and UF-1000i leucocytes. UC was positive in 455 episodes. GS correctly predicted urine culture of gram-negative rods (PPV 84.6%). Prediction was poor for gram-positive bacteria (PPV 38.4% (cocci), 1.0% (rods)). Conclusion: With the exception of a moderate prediction of gram-negative bacteria in the UC, urine GS does not improve UTI diagnosis at the ED compared to other urine parameters. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Kv1.3 blockade by ShK186 modulates CD4+ effector memory T-cell activity of patients with granulomatosis with polyangiitis.

Author

Lintermans, Lucas L, Stegeman, Coen A, Muñoz-Elías, Ernesto J, Tarcha, Eric J, Iadonato, Shawn P, Rutgers, Abraham, Heeringa, Peter, and Abdulahad, Wayel H

Subjects
*INTERLEUKINS, *IN vitro studies, *CYTOKINES, *RITUXIMAB, *FLOW cytometry, *IN vivo studies, *CARCINOGENS, *COVID-19, *VACCINES, *NURSING, *RHEUMATOLOGY, *GRANULOMATOSIS with polyangiitis, *RISK assessment, *RESEARCH funding, *TUMOR necrosis factors, *DESCRIPTIVE statistics, *T cells, *IMMUNOLOGIC memory, *MEMBRANE proteins
Abstract

Objectives Granulomatosis with polyangiitis (GPA) is a chronic relapsing systemic autoimmune vasculitis. Current treatment of GPA is unsatisfactory, as it relies on strong immunosuppressive regimens, with either CYC or rituximab, which reduce the immunogenicity of several vaccines and are risk factors for a severe form of COVID-19. This emphasizes the need to identify new drug targets and to develop treatment strategies with less harmful side effects. Since CD4+ effector memory T cells (TEM) play a key role in the pathogenesis of GPA, we aimed in this study to modulate CD4+TEM cell activity via Kv1.3 blockade using the specific peptide inhibiter, ShK-186. Methods Peripheral blood samples from 27 patients with GPA in remission and 16 age- and sex-matched healthy controls (HCs) were pre-incubated in vitro in the presence or absence of ShK-186, followed by stimulation with phorbol myristate acetate, calcium ionophore and brefeldin-A. The effect of ShK-186 on the cytokine production (IFNγ, TNFα, IL-4, IL-17, IL-21) within total and subsets of CD4+ T helper (CD4+TH) cells were assessed using flow cytometry. Results ShK-186 reduced the expression level of IFNγ, TNFα, IL-4, IL-17 and IL-21 in CD4+TH cells from patients with GPA in vitro. Further analysis performed on sorted CD4+T cell subsets, revealed that ShK-186 predominantly inhibited the cytokine production of CD4+TEM cells. ShK-186 treatment reduced the production of the pro-inflammatory cytokines to the level seen in CD4+ TH cells from HCs. Conclusions Modulation of cellular effector function by ShK-186 may constitute a novel treatment strategy for GPA with high specificity and less harmful side effects. [ABSTRACT FROM AUTHOR]

Published
2024
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16. External ureteric stent versus internal double J stent in kidney transplantation: a retrospective analysis on the incidence of urological complications and urinary tract infections

Author

Hazenberg, Ietje T., primary, Middelkoop, Stephanie J. M., additional, de Joode, Anoek A. E., additional, Rabbeljee, Juliette D., additional, Pol, Robert A., additional, Doornweerd, Benjamin H. J., additional, Sanders, Jan-Stephan F., additional, and Stegeman, Coen A., additional

Published
2023
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19. A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity

Author

Ooi, Joshua D., Jiang, Jhih-Hang, Eggenhuizen, Peter J., Chua, Ling L., van Timmeren, Mirjan, Loh, Khai L., O’Sullivan, Kim M., Gan, Poh Y., Zhong, Yong, Tsyganov, Kirill, Shochet, Lani R., Ryan, Jessica, Stegeman, Coen A., Fugger, Lars, Reid, Hugh H., Rossjohn, Jamie, Heeringa, Peter, Holdsworth, Stephen R., Peleg, Anton Y., and Kitching, A. Richard

Published
2019
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24. Timely administration of tocilizumab improves outcome of hospitalized COVID-19 patients

Author

Rutgers, Abraham, primary, Westerweel, Peter E., additional, van der Holt, Bronno, additional, Postma, Simone, additional, van Vonderen, Marit G. A., additional, Piersma, Djura P., additional, Postma, Douwe, additional, van den Berge, Maarten, additional, Jong, Eefje, additional, de Vries, Marten, additional, van der Burg, Leonie, additional, Huugen, Dennis, additional, van der Poel, Marjolein, additional, Kampschreur, Linda M., additional, Nijland, Marcel, additional, Strijbos, Jaap H., additional, Tamminga, Menno, additional, Mutsaers, Pim G. N. J., additional, Schol-Gelok, Suzanne, additional, Dijkstra-Tiekstra, Margriet, additional, Sidorenkov, Grigory, additional, Vincenten, Julien, additional, van Geffen, Wouter H., additional, Knoester, Marjolein, additional, Kosterink, Jos, additional, Gans, Reinold, additional, Stegeman, Coen, additional, Huls, Gerwin, additional, and van Meerten, Tom, additional

Published
2022
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25. Longitudinal monitoring of BKPyV miRNA levels in kidney transplant recipients with BKPyV‐related pathology reflects viral DNA levels and remain high in viremia patients after clearance of viral DNA

Author

van Doesum, Willem B., primary, Gard, Lilli, additional, Knijff, Laura W. D., additional, Niesters, Hubert G. M., additional, van Son, Willem J., additional, Stegeman, Coen A., additional, van den Berg, Anke, additional, Groen, Henk, additional, van den Born, Jacob, additional, Riezebos‐Brilman, Annelies, additional, and Sanders, Jan Stephan, additional

Published
2022
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26. CD163 and CD206 expression define distinct macrophage subsets involved in active ANCA-associated glomerulonephritis

Author

Aendekerk, Joop P, Jiemy, William F, Raveling-Eelsing, Elisabeth, Bijnens, Nele, Abdul-Hamid, Myrurgia A, Strating, Inge M, Dekkema, Gerjan J, Sanders, Jan-Stephan F, Stegeman, Coen A, Damoiseaux, Jan G M C, Little, Mark A, Heeringa, Peter, van Paassen, Pieter, Aendekerk, Joop P, Jiemy, William F, Raveling-Eelsing, Elisabeth, Bijnens, Nele, Abdul-Hamid, Myrurgia A, Strating, Inge M, Dekkema, Gerjan J, Sanders, Jan-Stephan F, Stegeman, Coen A, Damoiseaux, Jan G M C, Little, Mark A, Heeringa, Peter, and van Paassen, Pieter

Abstract

INTRODUCTION: Macrophages are key players in the immunopathology of anti-neutrophil cytoplasmic antibody (ANCA) mediated-vasculitis (AAV) with glomerulonephritis (ANCA GN). Different macrophage phenotypes are expected to play distinct roles in ANCA GN. Macrophages expressing CD163 and CD206 are found in lesions associated with ANCA GN. Hence, we aimed to investigate the clinicopathological significance of CD206 and CD163 in ANCA GN in a multicenter retrospective cohort study.MATERIAL AND METHODS: Patients with ANCA-associated vasculitis, with clinical data, serum and urine samples were included from three cohorts. Serum soluble CD206 (ssCD206) and urinary soluble CD163 (usCD163) levels were measured. Human kidney tissue samples (n = 53) were stained for CD206 and CD163 using immunohistochemistry and immunofluorescence, and findings were correlated with clinical and pathological data.RESULTS: In total, 210 patients were included (i.e., ANCA GN, n = 134; AAV without GN, n = 24; AAV in remission n = 52). Increased levels of both ssCD206 and usCD163 were seen in ANCA GN. High levels of ssCD206 declined after reaching remission, however, ssCD206 did not improve the accuracy of usCD163 to detect ANCA GN. Soluble markers correlated with histopathological findings. CD163+CD206- macrophages were found in the glomerulus and may play pivotal roles in glomerulonephritis, whereas CD206+CD163- and CD206+CD163+ macrophages were located tubulointerstitially and likely play a more prominent role in ANCA-associated tubulointerstitial inflammation. In ANCA GN patients increasing levels of ssCD206 increased the risk for end-stage renal disease and mortality.CONCLUSIONS: Our results confirm and extend the notion that CD206+ and CD163+ macrophages are prominent components of the cellular infiltrate in ANCA GN. We found distinct macrophage phenotypes that may play distinct roles in the immunopathology of ANCA GN and elaborate on a potential mechanism underlying the

Published
2022

34. EXTERNAL URETERIC STENT VS. INTERNAL DOUBLE J STENT IN RENAL TRANSPLANTATION: OCCURRENCE OF URINARY TRACT INFECTIONS AND UROLOGIC COMPLICATIONS

Author

Hazenberg, Margriet, Middelkoop, Stephanie, de Joode, Anoek, Sanders, Jan-Stephan, Pol, Robert, Stegeman, Coen, Groningen Institute for Organ Transplantation (GIOT), Groningen Kidney Center (GKC), ​Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), and Translational Immunology Groningen (TRIGR)

Published
2021

35. Circulating adrenomedullin and B-type natriuretic peptide do not predict blood pressure fluctuations during pheochromocytoma resection: a cross-sectional study

Author

Berends, Annika M A, primary, Buitenwerf, Edward, additional, Riphagen, Ineke J, additional, Lenders, Jacques W M, additional, Timmers, Henri J L M, additional, Kruijff, Schelto, additional, Links, Thera P, additional, van der Horst-Schrivers, Anouk N A, additional, Stegeman, Coen A, additional, Eekhoff, Elisabeth M W, additional, Feelders, Richard A, additional, Corssmit, Eleonora P M, additional, Groote Veldman, Ronald, additional, Haak, Harm R, additional, Muller Kobold, Anneke C, additional, and Kerstens, Michiel N, additional

Published
2021
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37. MASP-2 Is a Heparin-Binding Protease; Identification of Blocking Oligosaccharides

Author

Talsma, Ditmer T, Poppelaars, Felix, Dam, Wendy, Meter-Arkema, Anita H, Vivès, Romain R, Gál, Peter, Boons, Geert-Jan, Chopra, Pradeep, Naggi, Annamaria, Seelen, Marc A, Berger, Stephan P, Daha, Mohamed R, Stegeman, Coen A, van den Born, Jacob, Afd Chemical Biology and Drug Discovery, Sub Chemical Biology and Drug Discovery, Chemical Biology and Drug Discovery, Afd Chemical Biology and Drug Discovery, Sub Chemical Biology and Drug Discovery, Chemical Biology and Drug Discovery, Groningen Kidney Center (GKC), Groningen Institute for Organ Transplantation (GIOT), Translational Immunology Groningen (TRIGR), Institut de biologie structurale (IBS - UMR 5075), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), University of Georgia [USA], Institute for Chemical and Biochemical Research G. Ronzoni, and ANR-17-CE11-0040,SULFatAS,Structure et activités des sulfatases extracellulaires SULF(2017)

Subjects
0301 basic medicine, MECHANISM, POTENTIATION, Swine, Oligosaccharides, lectin pathway, heparin, Kidney, COMPONENT C4, chemistry.chemical_compound, 0302 clinical medicine, Sulfation, Lectins, LECTIN-PATHWAY, Immunology and Allergy, complement, Intestinal Mucosa, Lung, ComputingMilieux_MISCELLANEOUS, Original Research, Mannan, Agrin, Chemistry, 6-O-SULFATION, Heparin, Heparan sulfate, Tissue Donors, Biochemistry, Mannose-Binding Protein-Associated Serine Proteases, Lectin pathway, COMPLEMENT ACTIVATION, Protein Binding, medicine.drug, lcsh:Immunologic diseases. Allergy, tetrasaccharide, Immunology, ALTERNATIVE PATHWAY, 03 medical and health sciences, REVEALS, medicine, Animals, Humans, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], Sheep, MASP-2, Complement System Proteins, Complement system, 030104 developmental biology, glycosaminoglycans, Alternative complement pathway, Cattle, Heparitin Sulfate, lcsh:RC581-607, SULFATE, SYSTEM, 030215 immunology
Abstract

It is well-known that heparin and other glycosaminoglycans (GAGs) inhibit complement activation. It is however not known whether fractionation and/or modification of GAGs might deliver pathway-specific inhibition of the complement system. Therefore, we evaluated a library of GAGs and their derivatives for their functional pathway specific complement inhibition, including the MASP-specific C4 deposition assay. Interaction of human MASP-2 with heparan sulfate/heparin was evaluated by surface plasmon resonance, ELISA and in renal tissue. In vitro pathway-specific complement assays showed that highly sulfated GAGs inhibited all three pathways of complement. Small heparin- and heparan sulfate-derived oligosaccharides were selective inhibitors of the lectin pathway (LP). These small oligosaccharides showed identical inhibition of the ficolin-3 mediated LP activation, failed to inhibit the binding of MBL to mannan, but inhibited C4 cleavage by MASPs. Hexa- and pentasulfated tetrasaccharides represent the smallest MASP inhibitors both in the functional LP assay as well in the MASP-mediated C4 assay. Surface plasmon resonance showed MASP-2 binding with heparin and heparan sulfate, revealing high Kon and Koff rates resulted in a Kd of ~2 μM and confirmed inhibition by heparin-derived tetrasaccharide. In renal tissue, MASP-2 partially colocalized with agrin and heparan sulfate, but not with activated C3, suggesting docking, storage, and potential inactivation of MASP-2 by heparan sulfate in basement membranes. Our data show that highly sulfated GAGs mediated inhibition of all three complement pathways, whereas short heparin- and heparan sulfate-derived oligosaccharides selectively blocked the lectin pathway via MASP-2 inhibition. Binding of MASP-2 to immobilized heparan sulfate/heparin and partial co-localization of agrin/heparan sulfate with MASP, but not C3b, might suggest that in vivo heparan sulfate proteoglycans act as a docking platform for MASP-2 and possibly prevent the lectin pathway from activation.

Published
2020
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38. MASP-2 Is a Heparin-Binding Protease; Identification of Blocking Oligosaccharides

Author

Afd Chemical Biology and Drug Discovery, Sub Chemical Biology and Drug Discovery, Chemical Biology and Drug Discovery, Talsma, Ditmer T, Poppelaars, Felix, Dam, Wendy, Meter-Arkema, Anita H, Vivès, Romain R, Gál, Peter, Boons, Geert-Jan, Chopra, Pradeep, Naggi, Annamaria, Seelen, Marc A, Berger, Stephan P, Daha, Mohamed R, Stegeman, Coen A, van den Born, Jacob, Afd Chemical Biology and Drug Discovery, Sub Chemical Biology and Drug Discovery, Chemical Biology and Drug Discovery, Talsma, Ditmer T, Poppelaars, Felix, Dam, Wendy, Meter-Arkema, Anita H, Vivès, Romain R, Gál, Peter, Boons, Geert-Jan, Chopra, Pradeep, Naggi, Annamaria, Seelen, Marc A, Berger, Stephan P, Daha, Mohamed R, Stegeman, Coen A, and van den Born, Jacob

Published
2020

39. Timely Administration of Tocilizumab Improves Survival of Hospitalized COVID-19 Patients

Author

Rutgers, Abraham, primary, Westerweel, Peter E., additional, van der Holt, Bronno, additional, Postma, Simone, additional, van Vonderen, Marit G.A., additional, Piersma, Djura P., additional, Postma, Douwe, additional, van den Berge, Maarten, additional, Jong, Eefje, additional, de Vries, Marten, additional, van der Burg, Leonie, additional, Huugen, Dennis, additional, van der Poel, Marjolein, additional, Kampschreur, Linda M., additional, Nijland, Marcel, additional, Strijbos, Jaap H., additional, Tamminga, Menno, additional, Mutsaers, Pim G. N. J., additional, Schol-Gelok, Suzanne, additional, Dijkstra-Tiekstra, Margriet, additional, Sidorenkov, Grigory, additional, Vincenten, Julien, additional, van Geffen, Wouter H., additional, Knoester, Marjolein, additional, Kosterink, Jos, additional, Gans, Reinold, additional, Stegeman, Coen, additional, Huls, Gerwin, additional, and van Meerten, Tom, additional

Published
2021
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40. Contributors

Author

Abelson, Abby G., Abraham, Mary, Abramson, Steven B., Adachi, Jonathan D., Aggarwal, Rohit, Akira, Shizuo, Aletaha, Daniel, Ashraf Ali, Amjid, Allem, Kavitta B., Almehthel, Mohammed, Almohaya, Mohammed, Riera Alonso, Elena, Amigo, Mary-Carmen, Aringer, Martin, Arkema, Elizabeth V., Ascherman, Dana P., Atamas, Sergei P., Atkinson, Timothy J., Azeez, Maha A., Baer, Alan N., Baraliakos, Xenofon, Bardin, Thomas, Barnsley, Leslie, Barr, Andrew J., Bathon, Joan M., Belch, Jill J.F., Bellido, Teresita, Ben-Artzi, Ami, Benedetti, Fabrizio, Bennell, Kim L., Bennett, Sarah E., Berard, Roberta A., Berenbaum, Francis, Berman, Brian, Bermas, Bonnie L., Elizabeth Berry, Alice, Bertsias, George, Bhana, Suleman, Bhattacharyya, Shamik, Bilginer, Yelda, Bleasel, Jane F., Block, Joel A., Böhm, Markus, Bonelli, Michael, Boumpas, Dimitrios T., Bozec, Aline, Brasington, Richard D., Braun, Jürgen, Brouwer, Elisabeth, Brown, Jacques P., Brown, Matthew A., Brown, Matthew L., Buch, Maya H., Buckley, Christopher D., Bugbee, William D., Burmester, Gerd-Rüdiger, Burns, Jane C., Burr, David B., Buttgereit, Frank, Buxbaum, Joel N., Bykerk, Vivian P., Calabrese, Cassandra, Calabrese, Leonard H., Callen, Jeffrey P., Carr, Andrew J., Carrino, John A., Cavallo, Sabrina, Cervera, Ricard, Chang, Christopher, Chang, Joyce C., Chaon, Benjamin C., Chaudhary, Prateek, Choi, Hyon K., Choy, Ernest H.S., Christopher-Stine, Lisa, Chung, Lorinda, Ciccia, Francesco, Clauw, Daniel J., Clinch, Jacqui, Clowse, Megan E.B., Coghlan, John (Gerry), Colbert, Robert A., Conaghan, Philip G., Cooper, Cyrus, Costello, Wendy, Costenbader, Karen H., Cox, George L.D., Creamer, Paul, Cronstein, Bruce N., Cross, Raymond K., Curtis, Jeffrey R., D'Adamo, Chris, D'Agati, Vivette D., Daikh, David I., Dakin, Stephanie G., Dalbeth, Nicola, Davis, Aileen M., D'Cruz, David P., Eduardo de Barros Branco, Carlos, de Boer, Berber, De Craemer, Ann-Sophie, de Jesus, Adriana A., De Vita, Salvatore, de Wit, Maarten, Deal, Chad L., Deane, Kevin D., Dellaripa, Paul F., Dennison, Elaine, Denton, Christopher P., DiCarlo, Edward F., Distler, Oliver, Donlan, Pamela, Doyle, Tracy J., du Preez, Hannah, Dyer, George S.M., Eastell, Richard, Ehrchen, Jan, Elewaut, Dirk, Emery, Paul, Emmerling, Max R., Espinosa, Gerard, Espinoza, Luis R., Eyre, Stephen, Fanouriakis, Antonis, Farber, Joshua, Fasth, Anders, Feist, Eugen, Feldman, Candace H., Fernandez-Ruiz, Ruth, Filer, Andrew, Fiorentino, David F., Fisher, Benjamin A., Fisk, John D., Flajnik, Martin F., Forbess, Lindsy, Fox, David A., Frech, Tracy M., Frisaldi, Elisa, Gabay, Cem, Gadina, Massimo, Gandolfo, Saviana, Garelick, Daniela, Gay, Steffen, Geifman, Nophar, George, Michael D., Eric Gershwin, M., Ghadiali, Jay, Gilis, Elisabeth, Gold, Deborah T., Gold, Garry E., Goldbach-Mansky, Raphaela, Gómez-Puerta, José A., Goodman, Susan M., Gordon, Caroline, Gordon, Sharon, Gossec, Laure, Grainger, Andrew J., Grainger, Rebecca, Gravallese, Ellen M., Greenberg, Jeffrey D., Guglielmi, Luiza Guilherme, Gül, Ahmet, Gullapalli, Rao P., Guma, Monica, Gupta, Sarthak, Han, Shuhong, Hanly, John G., Hanson, Eric P., Haraoui, Boulos, Harley, John B., Haroun, Tayseer G., Hashkes, Philip J., Hasni, Sarfaraz A., Bassim Hassan, Andrew, Haupt, Lukas, Hausmann, Jonathan S., Hawker, Gillian A., Heiberg, Turid, Helfgott, Simon M., Hinman, Rana S., Hoffmann-Vold, Anna-Maria, Holroyd, Christopher R., Holt, Cathy, Horomanski, Audra, Huizinga, Thomas W.J., Humby, Frances, Elaine Husni, M., Hwang, Jonathan, Hyrich, Kimme, Inman, Robert D., Inoue, Dai, Isaac, Zacharia, Isaacs, John D., Isenberg, David, Iversen, Maura D., Jabs, Douglas A., James, Judith A., Jandali, Bochra, Kassim Javaid, M., Javier, Rose-Marie, Jefferis, Roy, Jeffries, Matlock A., Johnson, Sindhu R., Johnstone, Brian, Helena Jonsson, Anna, Joyce, Andrew A., Jung, Michelle, Kado, Ruba, Kaisho, Tsuneyasu, Kamal, Natasha, Kane, David, Kaplan, Mariana J., Karr, Timothy L., Kassimos, Dimitrios G., Kastner, Daniel L., Katz, Jeffrey N., Kawano, Mitsuhiro, Kay, Jonathan, Keating, Richard M., Kelly, Jennifer A., Kendler, David, Keyser, Randall E., Khamashta, Munther A., Khanna, Dinesh, Khokhar, Kiran, Kiefer, David, King, Lauren K., Kloppenburg, Margreet, Kolasinski, Sharon L., Kolstad, Kathleen D., Kottyan, Leah C., Byers Kraus, Virginia, Kronberger, Leo R.W., Kroopnick, Jeffrey M., Kvien, Tore K., LaBaer, Joshua, Lafyatis, Robert, Lakkis, Jay I., Landewé, Robert B.M., Langford, Carol A., Laster, Marciana L., Latourte, Augustin, Lau, Arthur N., Laurynenka, Viktoryia, Lavin, Robert A., Laxer, Ronald M., Li, Suzanne C., Liao, Katherine P., Lieberman, Scott M., Liew, Jean W., Littlejohn, Geoffrey O., Liu, Eva S., Lo, Lawrence, Lories, Rik J., Luger, Thomas A., Lundberg, Ingrid E., Luqmani, Raashid A., Machado, Pedro M., Machold, Klaus P., Ronald MacKenzie, C., Major, Tanya J., Malfait, Anne-Marie, Malley, Tamir, Manasson, Julia, March, Lyn M., Olivé Marqués, Alejandro, Márquez, Javier, Martin, Paul, Martínez-Lavín, Manuel, Matteson, Eric L., Mayes, Maureen D., McAlindon, Timothy, McCarthy, Edward F., McCarthy, Geraldine M., McDermott, Michael F., McDonnell, Patrick J., McGonagle, Dennis, Simon Meara, Alexa, Mehta, Jay J., Melville, Andrew R., Merola, Joseph F., Micheletti, Robert G., Michou, Laëtitia, Middleton, Rob, Midha, Disha, Mikdashi, Jamal A., Miller, Frederick W., Minden, Kirsten, Miner, Jonathan J., Minhas, Deeba, Helene Moe, Rikke, Möller, Ingrid, Mopuru, Renuka, Mortaji, Parisa, Mueller, Alisa A., Myasoedova, Elena, Namur, Gauthier, Naredo, Esperanza, Navarro-Compán, Victoria, Neerinckx, Barbara, Nelson, Amanda E., Nerviani, Alessandra, Nicolson, Philippa J.A., Nordal, Ellen B., Nöth, Ulrich, Ntatsaki, Eleana, Obenhuber, Tilman, Oddis, Chester V., Ogdie-Beatty, Alexis R., Omar, Ahmed, Ombrello, Michael J., Omisade, Antonina, Onel, Karen B., Ong, Voon H., Orcel, Philippe, Orozco, Gisela, Orr, Carl, O'Shea, John J., Ospelt, Caroline, Østensen, Monika, Özen, Seza, Park, Elizabeth, Parker, Matthew J.S., Pathan, Ejaz, Patrono, Carlo, Perez-Chada, Lourdes M., Pijnenburg, Luc, Pillinger, Michael H., Pineda, Carlos, Pipitone, Nicolò, Pitzalis, Costantino, Poddubnyy, Denis, Pope, Janet E., Postolova, Anna, Price, Andrew J., Pryor, Katherine P., Quartuccio, Luca, Rackwitz, Lars, Radner, Helga, Rajendran, Aardra, Ramiro, Sofia, Raychaudhuri, Soumya, Redmond, Anthony C., Reeves, Westley H., Remmers, Elaine F., Requena, Luis, Reynolds, Gary, Reynolds, John A., Ribbens, Clio, Richards, Bethan, Richardson, Bruce, Richette, Pascal, Ritchlin, Christopher T., Ritter, Susan Y., Robinson, Philip C., Robinson, William H., Rogers, Valerie J., Romain, Paul L., Rosas, Ivan O., Rosenthal, Ann K., Rubin, Elka, Rudwaleit, Martin, Rutgers, Bram A., Rygg, Marite, Saag, Kenneth G., Salmon, Jane E., Salusky, Isidro B., Salvarani, Carlo, Sandell, Linda J., Sandhu, Vaneet K., Sandovici, Maria, Sand-Svartrud, Anne-Lene, Scanzello, Carla R., Schaible, Hans-Georg, Scher, Jose U., Schett, Georg, Schiffenbauer, Adam I., Schiller, Alan L., Schlesinger, Naomi, Schreiber, Benjamin E., Schwartz, Daniella M., Shaibani, Aziz, Sharma, Leena, Shmerling, Robert H., Siaton, Bernadette C., Siegel, Richard M., Sieghart, Daniela, Silverman, Stuart L., Simard, Julia F., Simmons, Barry P., Simms, Robert W., Singer, Nora G., Sirotich, Emily, Smith, Judith A., Smith, Stacy E., Smolen, Josef S., Solomon, Daniel H., Sparks, Jeffrey A., Stack, John, Stanley, David, Steen, Virginia D., Steere, Allen C., Stegeman, Coen A., Steiner, Günter, Steinert, Andre F., Stojan, George, Strand, Vibeke, Sufka, Paul, Sullivan, James K., Szulc, Pawel, Tang, Chen, Tang, Shiyu, Taylor, Peter C., Terkeltaub, Robert, Thomas, Afton R., Thorne, Jennifer E., Topping, Louise M., Toprover, Michael, Torralba, Karina, Touma, Zahi, Tremoulet, Adriana H., Trouw, Leendert, Tuan, Rocky S., Uçkay, Ilker, Umehara, Hisanori, van der Geest, Kornelis S.M., van der Heijde, Désirée, van Gaalen, Floris A., Van Mechelen, Margot, van Vollenhoven, Ronald F., Vandevelde, Claire Y.J., Varga, John, Vassilopoulos, Dimitrios, Veale, Douglas J., Verstappen, Gwenny M., Viatte, Sebastien, Vincent, Tonia L., Vital, Edward M., von Loga, Isabell S., Wahezi, Dawn M., Wallace, Daniel J., Wallace, Zachary S., Warburton, Gary, Watad, Abdulla, Watts, Richard A., Weinblatt, Michael E., Weir, Matthew R., Weisman, Michael H., Weiss, Pamela F., Branford White, Harriet, White, Kenneth E., Wilkinson, David J., Williams, David E., Williams, Richard, Wilson, Hannah, Winthrop, Kevin L., Witt, Claudia M., Witzmann, Gerhard, Wong, John B., Woolf, Anthony D., Paul Wordsworth, B., Xu, Huji, Yazdany, Jinoos, Young, David A., Young, Stephen P., Md Yusof, Md Yuzaiful, and Zhuang, Haoyang

Published
2023
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49. Evidence for enhanced Bruton’s tyrosine kinase activity in transitional and naïve B cells of patients with granulomatosis with polyangiitis

Author

von Borstel, Anouk, primary, Abdulahad, Wayel H, additional, Sanders, Jan Stephan, additional, Rip, Jasper, additional, Neys, Stefan F H, additional, Hendriks, Rudi W, additional, Stegeman, Coen A, additional, Heeringa, Peter, additional, Rutgers, Abraham, additional, and Corneth, Odilia B J, additional

Published
2019
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50. 144. GEOGRAPHIC DIFFERENCES IN CLINICAL PRESENTATION AND OUTCOME OF ANTINEUTROPHIL CYTOPLASMIC ANTIBODY- ASSOCIATED VASCULITIS: ROLE OF ANTIBODY SPECIFICITY

Author

Hessels, Arno, primary, Sanders, Jan Stephan, additional, Schau, Bruno, additional, Ochtrop, Manuella, additional, Calich, Ana, additional, de Souza, Alexandre Wagner, additional, Li, Zhi-Ying, additional, Chen, Min, additional, Rutgers, Abraham, additional, and Stegeman, Coen, additional

Published
2019
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