Search

Your search keyword '"Stas, Marguerite"' showing total 118 results
Start Over Author "Stas, Marguerite" Publication Year Range Last 10 years
118 results on '"Stas, Marguerite"'

1. Variation in response rates to isolated limb perfusion in different soft-tissue tumour subtypes: an international multi-centre study

Author

Reijers, Sophie J.M., Davies, Emma, Grünhagen, Dirk J., Fiore, Marco, Honore, Charles, Rastrelli, Marco, Vassos, Nikolaos, Podleska, Lars E., Niethard, Maya, Jakob, Jens, Perhavec, Andraz, Duarte, Carlos, González, Felipe, Deroose, Jan P., Stas, Marguerite, Boecxstaens, Veerle, Schrage, Yvonne, Snow, Hayden, Algarra, Salvador Martín, Said, Hector Martinez, Garcia-Ortega, Dorian Yarih, Martin, Karla, Mattsson, Jan, Djafarrian, Reza, Di Lorenzo, Giorgia, Colombo, Chiara, Gronchi, Alessandro, Matter, Maurice, Verhoef, Cornelis, Olofsson Bagge, Roger, Hohenberger, Peter, Hayes, Andrew J., and van Houdt, Winan J.

Published
2023
Full Text
View/download PDF

2. Clinical and genetic determinants of vitamin D receptor expression in cutaneous melanoma patients

Author

De Smedt, Julie, primary, Aura, Claudia, additional, Van Kelst, Sofie, additional, Janssen, Laudine, additional, Marasigan, Vivien, additional, Boecxstaens, Veerle, additional, Stas, Marguerite, additional, Bogaerts, Kris, additional, Belmans, Ann, additional, Cleynen, Isabelle, additional, Vanderschueren, Dirk, additional, Vandenberghe, Katleen, additional, Bechter, Oliver, additional, Nikkels, Arjen, additional, Strobbe, Tinne, additional, Emri, Gabriella, additional, Lambrechts, Dieter, additional, and Garmyn, Marjan, additional

Published
2024
Full Text
View/download PDF

4. Data from Establishment and Characterization of Histologically and Molecularly Stable Soft-tissue Sarcoma Xenograft Models for Biological Studies and Preclinical Drug Testing

Author

Cornillie, Jasmien, primary, Wozniak, Agnieszka, primary, Li, Haifu, primary, Wang, Yannick, primary, Boeckx, Bram, primary, Gebreyohannes, Yemarshet K., primary, Wellens, Jasmien, primary, Vanleeuw, Ulla, primary, Hompes, Daphne, primary, Stas, Marguerite, primary, Sinnaeve, Friedl, primary, Wafa, Hazem, primary, Lambrechts, Diether, primary, Debiec-Rychter, Maria, primary, Sciot, Raf, primary, and Schöffski, Patrick, primary

Published
2023
Full Text
View/download PDF

5. Supplementary Figure S1 from Establishment and Characterization of Histologically and Molecularly Stable Soft-tissue Sarcoma Xenograft Models for Biological Studies and Preclinical Drug Testing

Author

Cornillie, Jasmien, primary, Wozniak, Agnieszka, primary, Li, Haifu, primary, Wang, Yannick, primary, Boeckx, Bram, primary, Gebreyohannes, Yemarshet K., primary, Wellens, Jasmien, primary, Vanleeuw, Ulla, primary, Hompes, Daphne, primary, Stas, Marguerite, primary, Sinnaeve, Friedl, primary, Wafa, Hazem, primary, Lambrechts, Diether, primary, Debiec-Rychter, Maria, primary, Sciot, Raf, primary, and Schöffski, Patrick, primary

Published
2023
Full Text
View/download PDF

6. Supplementary Table S1 from Establishment and Characterization of Histologically and Molecularly Stable Soft-tissue Sarcoma Xenograft Models for Biological Studies and Preclinical Drug Testing

Author

Cornillie, Jasmien, primary, Wozniak, Agnieszka, primary, Li, Haifu, primary, Wang, Yannick, primary, Boeckx, Bram, primary, Gebreyohannes, Yemarshet K., primary, Wellens, Jasmien, primary, Vanleeuw, Ulla, primary, Hompes, Daphne, primary, Stas, Marguerite, primary, Sinnaeve, Friedl, primary, Wafa, Hazem, primary, Lambrechts, Diether, primary, Debiec-Rychter, Maria, primary, Sciot, Raf, primary, and Schöffski, Patrick, primary

Published
2023
Full Text
View/download PDF

7. Data from Antitumor Immunity Triggered by Melphalan Is Potentiated by Melanoma Cell Surface–Associated Calreticulin

Author

Dudek-Perić, Aleksandra M., primary, Ferreira, Gabriela B., primary, Muchowicz, Angelika, primary, Wouters, Jasper, primary, Prada, Nicole, primary, Martin, Shaun, primary, Kiviluoto, Santeri, primary, Winiarska, Magdalena, primary, Boon, Louis, primary, Mathieu, Chantal, primary, van den Oord, Joost, primary, Stas, Marguerite, primary, Gougeon, Marie-Lise, primary, Golab, Jakub, primary, Garg, Abhishek D., primary, and Agostinis, Patrizia, primary

Published
2023
Full Text
View/download PDF

9. Supplementary Tables 1-3 from Antitumor Immunity Triggered by Melphalan Is Potentiated by Melanoma Cell Surface–Associated Calreticulin

Author

Dudek-Perić, Aleksandra M., primary, Ferreira, Gabriela B., primary, Muchowicz, Angelika, primary, Wouters, Jasper, primary, Prada, Nicole, primary, Martin, Shaun, primary, Kiviluoto, Santeri, primary, Winiarska, Magdalena, primary, Boon, Louis, primary, Mathieu, Chantal, primary, van den Oord, Joost, primary, Stas, Marguerite, primary, Gougeon, Marie-Lise, primary, Golab, Jakub, primary, Garg, Abhishek D., primary, and Agostinis, Patrizia, primary

Published
2023
Full Text
View/download PDF

10. Supplementary materials and methods from Antitumor Immunity Triggered by Melphalan Is Potentiated by Melanoma Cell Surface–Associated Calreticulin

Author

Dudek-Perić, Aleksandra M., primary, Ferreira, Gabriela B., primary, Muchowicz, Angelika, primary, Wouters, Jasper, primary, Prada, Nicole, primary, Martin, Shaun, primary, Kiviluoto, Santeri, primary, Winiarska, Magdalena, primary, Boon, Louis, primary, Mathieu, Chantal, primary, van den Oord, Joost, primary, Stas, Marguerite, primary, Gougeon, Marie-Lise, primary, Golab, Jakub, primary, Garg, Abhishek D., primary, and Agostinis, Patrizia, primary

Published
2023
Full Text
View/download PDF

13. Supplementary Figures 1-6 from Antitumor Immunity Triggered by Melphalan Is Potentiated by Melanoma Cell Surface–Associated Calreticulin

Author

Dudek-Perić, Aleksandra M., primary, Ferreira, Gabriela B., primary, Muchowicz, Angelika, primary, Wouters, Jasper, primary, Prada, Nicole, primary, Martin, Shaun, primary, Kiviluoto, Santeri, primary, Winiarska, Magdalena, primary, Boon, Louis, primary, Mathieu, Chantal, primary, van den Oord, Joost, primary, Stas, Marguerite, primary, Gougeon, Marie-Lise, primary, Golab, Jakub, primary, Garg, Abhishek D., primary, and Agostinis, Patrizia, primary

Published
2023
Full Text
View/download PDF

22. Determinants of 25-hydroxyvitamin D Status in a Cutaneous Melanoma Population

Author

De Smedt, Julie, primary, Van Kelst, Sofie, additional, Janssen, Laudine, additional, Marasigan, Vivien, additional, Boecxstaens, Veerle, additional, Stas, Marguerite, additional, Vanderschueren, Dirk, additional, Guler, Ipek, additional, Bogaerts, Kris, additional, Vandenberghe, Katleen, additional, Bechter, Oliver, additional, Billen, Jaak, additional, Nikkels, Arjen, additional, Strobbe, Tine, additional, Emri, Gabriella, additional, Lambrechts, Diether, additional, and Garmyn, Marjan, additional

Published
2022
Full Text
View/download PDF

23. Isolated Limb Perfusion in the Treatment of In-Transit Melanoma Metastases: Are There Predictive Factors for the Outcome?

Author

Stas Marguerite, Bechter Oliver, Boecxstaens Veerle, Garmyn Marjan, Roel Bolckmans, Van den Oord Joost, and Wolter Pascal

Subjects
Melphalan, medicine.medical_specialty, business.industry, medicine.medical_treatment, Melanoma, medicine.disease, Systemic therapy, Primary tumor, Radiation therapy, Dissection, medicine.anatomical_structure, medicine, Radiology, Stage (cooking), business, Lymph node, medicine.drug
Abstract

Introduction: Isolated limb perfusion (ILP) with delivery of high dose melphalan proved to be efficient in the treatment of in-transit metastases (ITM). Preoperative factors may carry an impact on patient outcome, including in-field or local progression-free survival (IPFS), time to distant metastases (TDM) and overall survival (OS). Materials and Methods: A retrospective analysis of 83 patients who underwent an ILP at our institution before the era of efficient upfront systemic therapy in high-risk cases. Patients were classified according to a modified M.D. Anderson score, with relevance for the outcome: 34 stage III A (patients with satellites and/or ITM), 31 stage III AB (patients with synchronous regional lymph node metastases and satellites and/or ITM), 11 at a new stage labelled III A(B) which takes into account a previous history of therapeutic regional node dissection and actual recurrence in the limb only, and 7 stage IV (metastatic cases with actual major problem of recurrence in the limb). Results: Our median follow-up time was 90.1 months (IQR 72.8-151.6). Median IPFS was 16.3 months (95% CI 9.5-78.5), median TDM 28.8 months (95% CI 15.4-69.6) and median OS 34.6 months (95% CI 21.1-59.5). The strongest significant prognostic factor regarding IPFS was LND before ILP (p=0.02). However, sex (p=0.03/0.07), LND before ILP (p=0.004/0.11) and some primary tumor characteristics (Clark level (p=0.15/0.07) and ulceration (p=0.006/0.04)) were prognostic regarding TDM and / or OS. Conclusion: ILP with melphalan can provide long-term regional and systemic tumor control in a selected group of patients and should be kept in mind for patients recurring after local surgery or radiotherapy and resistant to or ineligible for the newer systemic therapies.

Published
2020

24. Road to Metastasis: The TWEAK Pathway as a Discriminant between Metastasizing and Non-Metastasizing Thick Melanomas

Author

Güvenç, Canan, primary, Antoranz, Asier, additional, Szumera-Ciećkiewicz, Anna, additional, Teterycz, Pawel P., additional, Rutkowski, Piotr R., additional, Rawson, Robert V., additional, Scolyer, Richard A., additional, Thompson, John F., additional, Newton-Bishop, Julia, additional, Stas, Marguerite, additional, Boecxstaens, Veerle, additional, Bechter, Oliver, additional, Vercauteren, Jurgen, additional, Garmyn, Marjan, additional, van den Oord, Joost, additional, and Bosisio, Francesca Maria, additional

Published
2021
Full Text
View/download PDF

25. Functional heterogeneity of lymphocytic patterns in primary melanoma dissected through single-cell multiplexing

Author

Bosisio, F, Antoranz, A, van Herck, Y, Bolognesi, M, Marcelis, L, Chinello, C, Wouters, J, Magni, F, Alexopoulos, L, Stas, M, Boecxstaens, V, Bechter, O, Cattoretti, G, van den Oord, J, Bosisio, Francesca Maria, Antoranz, Asier, van Herck, Yannick, Bolognesi, Maddalena Maria, Marcelis, Lukas, Chinello, Clizia, Wouters, Jasper, Magni, Fulvio, Alexopoulos, Leonidas, Stas, Marguerite, Boecxstaens, Veerle, Bechter, Oliver, Cattoretti, Giorgio, van den Oord, Joost, Bosisio, F, Antoranz, A, van Herck, Y, Bolognesi, M, Marcelis, L, Chinello, C, Wouters, J, Magni, F, Alexopoulos, L, Stas, M, Boecxstaens, V, Bechter, O, Cattoretti, G, van den Oord, J, Bosisio, Francesca Maria, Antoranz, Asier, van Herck, Yannick, Bolognesi, Maddalena Maria, Marcelis, Lukas, Chinello, Clizia, Wouters, Jasper, Magni, Fulvio, Alexopoulos, Leonidas, Stas, Marguerite, Boecxstaens, Veerle, Bechter, Oliver, Cattoretti, Giorgio, and van den Oord, Joost

Abstract

In melanoma, the lymphocytic infiltrate is a prognostic parameter classified morphologically into ‘brisk’, ‘non-brisk’ and ‘absent’ entailing a functional association that has never been proved. Recently, it has been shown that lymphocytic populations can be very heterogeneous, and that anti-PD-1 immunotherapy supports activated T cells. Here, we characterize the immune landscape in primary melanoma by high-dimensional single-cell multiplex analysis in tissue sections (MILAN technique) followed by image analysis, RT-PCR and shotgun proteomics. We observed that the brisk and non-brisk patterns are heterogeneous functional categories that can be further sub-classified into active, transitional or exhausted. The classification of primary melanomas based on the functional paradigm also shows correlation with spontaneous regression, and an improved prognostic value when compared to that of the brisk classification. Finally, the main inflammatory cell subpopulations that are present in the microenvironment associated with activation and exhaustion and their spatial relationships are described using neighbourhood analysis.

Published
2020

26. Recommendations for skin cancer consultation and surgery during COVID-19 pandemic

Author

Brochez, Lieve, Baurain, Jean-Francois, Del Marmol, Véronique, Nikkels, Arjen A.F., Kruse, V., Sales, François, Stas, Marguerite, Van Laethem, A., Garmyn, Marjan, Brochez, Lieve, Baurain, Jean-Francois, Del Marmol, Véronique, Nikkels, Arjen A.F., Kruse, V., Sales, François, Stas, Marguerite, Van Laethem, A., and Garmyn, Marjan

Abstract

SCOPUS: no.j, info:eu-repo/semantics/published

Published
2020

27. GAVeCeLT-WoCoVA Consensus on subcutaneously anchored securement devices for the securement of venous catheters: Current evidence and recommendations for future research

Author

Pinelli, Fulvio, primary, Pittiruti, Mauro, additional, Van Boxtel, Ton, additional, Barone, Giovanni, additional, Biffi, Roberto, additional, Capozzoli, Giuseppe, additional, Crocoli, Alessandro, additional, Elli, Stefano, additional, Elisei, Daniele, additional, Fabiani, Adam, additional, Garrino, Cristina, additional, Graziano, Ugo, additional, Montagnani, Luca, additional, Prato, Alessio Pini, additional, Scoppettuolo, Giancarlo, additional, Zadra, Nicola, additional, Zanaboni, Clelia, additional, Zerla, Pietro, additional, Konstantinou, Evangelos, additional, Jones, Matt, additional, Rosay, Hervé, additional, Simcock, Liz, additional, Stas, Marguerite, additional, and Pepe, Gilda, additional

Published
2020
Full Text
View/download PDF

28. Functional heterogeneity of lymphocytic patterns in primary melanoma dissected through single-cell multiplexing

Author

Bosisio, Francesca Maria, primary, Antoranz, Asier, additional, van Herck, Yannick, additional, Bolognesi, Maddalena Maria, additional, Marcelis, Lukas, additional, Chinello, Clizia, additional, Wouters, Jasper, additional, Magni, Fulvio, additional, Alexopoulos, Leonidas, additional, Stas, Marguerite, additional, Boecxstaens, Veerle, additional, Bechter, Oliver, additional, Cattoretti, Giorgio, additional, and van den Oord, Joost, additional

Published
2020
Full Text
View/download PDF

29. Author response: Functional heterogeneity of lymphocytic patterns in primary melanoma dissected through single-cell multiplexing

Author

Bosisio, Francesca Maria, primary, Antoranz, Asier, additional, van Herck, Yannick, additional, Bolognesi, Maddalena Maria, additional, Marcelis, Lukas, additional, Chinello, Clizia, additional, Wouters, Jasper, additional, Magni, Fulvio, additional, Alexopoulos, Leonidas, additional, Stas, Marguerite, additional, Boecxstaens, Veerle, additional, Bechter, Oliver, additional, Cattoretti, Giorgio, additional, and van den Oord, Joost, additional

Published
2020
Full Text
View/download PDF

30. XenoSarc: A comprehensive platform of patient-derived xenograft (PDX) models of soft tissue sarcoma (STS) for early drug testing.

Author

Schoffski, Patrick, primary, Van Renterghem, Britt, additional, Cornillie, Jasmien, additional, Wang, Yannick, additional, Gebreyohannes, Yemarshet Kelemework, additional, Lee, Che-Jui, additional, Wellens, Jasmien, additional, Vanleeuw, Ulla, additional, Nysen, Madita, additional, Hompes, Daphne, additional, Stas, Marguerite, additional, Sinnaeve, Friedl, additional, Wafa, Hazem, additional, Topal, Baki, additional, Verbelen, Tom, additional, Debiec-Rychter, Maria, additional, Sciot, Raf, additional, and Wozniak, Agnieszka, additional

Published
2019
Full Text
View/download PDF

31. Establishment and Characterization of Histologically and Molecularly Stable Soft-tissue Sarcoma Xenograft Models for Biological Studies and Preclinical Drug Testing

Author

Cornillie, Jasmien, primary, Wozniak, Agnieszka, additional, Li, Haifu, additional, Wang, Yannick, additional, Boeckx, Bram, additional, Gebreyohannes, Yemarshet K., additional, Wellens, Jasmien, additional, Vanleeuw, Ulla, additional, Hompes, Daphne, additional, Stas, Marguerite, additional, Sinnaeve, Friedl, additional, Wafa, Hazem, additional, Lambrechts, Diether, additional, Debiec-Rychter, Maria, additional, Sciot, Raf, additional, and Schöffski, Patrick, additional

Published
2019
Full Text
View/download PDF

32. Clinical presentation, natural history and therapeutic approach in patients with solitary fibrous tumor: A retrospective analysis.

Author

Schoffski, Patrick, primary, Timmermans, Iris, additional, Hompes, Daphne, additional, Stas, Marguerite, additional, Boecxstaens, Veerle, additional, De Leyn, Paul, additional, Coosemans, Willy, additional, Van Raemdonck, Dirk, additional, Hauben, Esther, additional, Sciot, Raf, additional, Clement, Paul M., additional, Bechter, Oliver Edgar, additional, Beuselinck, Benoit, additional, Woei-A-Jin, Feng Jung Sherida Harriette, additional, Dumez, Herlinde, additional, and Wessels, Tim, additional

Published
2019
Full Text
View/download PDF

33. Pazopanib, a Receptor Tyrosine Kinase Inhibitor, Suppresses Tumor Growth through Angiogenesis in Dedifferentiated Liposarcoma Xenograft Models123

Author

Li, Haifu, Wozniak, Agnieszka, Sciot, Raf, Cornillie, Jasmien, Wellens, Jasmien, Van Looy, Thomas, Vanleeuw, Ulla, Stas, Marguerite, Hompes, Daphne, Debiec-Rychter, Maria, and Schöffski, Patrick

Subjects
Article
Abstract

INTRODUCTION: The rarity of dedifferentiated liposarcoma (DDLPS) and the lack of experimental DDLPS models limit the development of novel therapeutic strategies. Pazopanib (PAZ) is a tyrosine kinase inhibitor that is approved for the treatment of non-adipocytic advanced soft tissue sarcoma. The activity of this agent has not yet been properly explored in preclinical liposarcoma models nor in a randomized phase Ш clinical trial in this entity. The aim of the present study was to investigate whether PAZ had antitumor activity in DDLPS models in vivo. MATERIAL AND METHODS: We established two patient-derived DDLPS xenograft models (UZLX-STS3 and UZLX-STS5) through implantation of tumor material from sarcoma patients in athymic nude NMRI mice. An animal model of the SW872 liposarcoma cell line was also used. To investigate the efficacy of PAZ in vivo, mice bearing tumors were treated for 2 weeks with sterile water, doxorubicin (1.2 mg/kg, intraperitoneally, twice per week), PAZ [40 mg/kg, orally (p.o.), twice per day], or PAZ plus doxorubicin (same schedules as for single treatments). RESULTS: Patient-derived xenografts retained the histologic and molecular features of DDLPS. PAZ significantly delayed tumor growth by decreasing proliferation and inhibited angiogenesis in all models tested. Combining the angiogenesis inhibitor with an anthracycline did not show superior efficacy. CONCLUSION: These results suggest that PAZ has potential antitumor activity in DDLPS primarily through antiangiogenic effects and therefore should be explored in clinical trials.

Published
2014

34. GAVeCeLT-WoCoVA Consensus on subcutaneously anchored securement devices for the securement of venous catheters: Current evidence and recommendations for future research

Author

Pinelli, Fulvio, Pittiruti, Mauro, Van Boxtel, Ton, Barone, Giovanni, Biffi, Roberto, Capozzoli, Giuseppe, Crocoli, Alessandro, Elli, Stefano, Elisei, Daniele, Fabiani, Adam, Garrino, Cristina, Graziano, Ugo, Montagnani, Luca, Prato, Alessio Pini, Scoppettuolo, Giancarlo, Zadra, Nicola, Zanaboni, Clelia, Zerla, Pietro, Konstantinou, Evangelos, Jones, Matt, Rosay, Hervé, Simcock, Liz, Stas, Marguerite, and Pepe, Gilda

Abstract

Background: Subcutaneously anchored securement devices (or subcutaneous engineered securement devices) have been introduced recently into the clinical practice, but the number of published studies is still scarce. The Italian Group of Long-Term Central Venous Access Devices (GAVeCeLT)—in collaboration with WoCoVA (World Congress on Vascular Access)—has developed a Consensus about the effectiveness, safety, and cost-effectiveness of such devices.Methods: After the definition of a panel of experts, a systematic collection and review of the literature on subcutaneously anchored securement devices was performed. The panel has been divided in two working groups, one focusing on adult patients and the other on children and neonates.Results: Although the quality of evidence is generally poor, since it is based mainly on non-controlled prospective studies, the panel has concluded that subcutaneously anchored securement devices are overall effective in reducing the risk of dislodgment and they appear to be safe in all categories of patients, being associated only with rare and negligible local adverse effects; cost-effectiveness is demonstrated—or highly likely—in specific populations of patients with long-term venous access and/or at high risk of dislodgment.Conclusion: Subcutaneously anchored securement is a very promising strategy for avoiding dislodgment. Further studies are warranted, in particular for the purpose of defining (a) the best management of the anchoring device so to avoid local problems, (b) the patient populations in which it may be considered highly cost-effective and even mandatory, (c) the possible benefit in terms of reduction of other catheter-related complications such as venous thrombosis and/or infection, and—last but not least—(d) their impact on the workload and stress level of nurses taking care of the devices.

Published
2021
Full Text
View/download PDF

36. Functional heterogeneity of lymphocytic patterns in primary melanoma dissected through single-cell multiplexing

Author

Maria Bosisio, Francesca, primary, Antoranz, Asier, additional, van Herck, Yannick, additional, Maria Bolognesi, Maddalena, additional, Marcelis, Lukas, additional, Chinello, Clizia, additional, Wouters, Jasper, additional, Magni, Fulvio, additional, Alexopoulos, Leonidas, additional, Stas, Marguerite, additional, Boecxstaens, Veerle, additional, Bechter, Oliver, additional, Cattoretti, Giorgio, additional, and van den Oord, Joost, additional

Published
2018
Full Text
View/download PDF

37. Abstract 1031: XenoSarc: Patient-derived xenograft (PDX) models of soft tissue sarcoma (STS)—an update on a preclinical platform for early drug testing

Author

Wozniak, Agnieszka, primary, Cornillie, Jasmien, additional, Gebreyohannes, Yemarshet K., additional, Wang, Yannick, additional, Wellens, Jasmien, additional, Vanleeuw, Ulla, additional, Hompes, Daphne, additional, Stas, Marguerite, additional, Sinnaeve, Friedl, additional, Wafa, Hazem, additional, Debiec-Rychter, Maria, additional, Sciot, Raf, additional, and Schöffski, Patrick, additional

Published
2018
Full Text
View/download PDF

40. Abstract 4811: XenoSarc: Patient-derived xenograft (PDX) models of soft tissue sarcoma (STS), an update on a preclinical platform for early drug testing

Author

Wozniak, Agnieszka, primary, Cornillie, Jasmien, additional, Gebreyohannes, Yemarshet K., additional, Wellens, Jasmien, additional, Vreys, Lise, additional, Hompes, Daphne, additional, Stas, Marguerite, additional, Sinnaeve, Friedl, additional, Debiec-Rychter, Maria, additional, Sciot, Raf, additional, and Schöffski, Patrick, additional

Published
2017
Full Text
View/download PDF

44. Solar Lentigines are Associated with Better Outcome in Cutaneous Melanoma.

Author

MARASIGAN, Vivien, GÜVENÇ, Canan, VAN DEN OORD, Joost J., STAS, Marguerite, BOECXSTAENS, Veerle, BECHTER, Oliver, WOLTER, Pascal, LAMBRECHTS, Diether, and GARMYN, Marjan

Subjects
LENTIGO, MELANOMA, BONFERRONI correction, FAMILY history (Medicine)
Abstract

The rising incidence of cutaneous melanoma and its stable high mortality rates despite innovative cancer care, require better prediction of the clinical outcome. In a large cutaneous melanoma population we explored whether the known clinical risk factors for melanoma susceptibility (naevus phenotype, phototype, family and personal history of melanoma and sun damage) affect melanoma outcomes. A total of 1,530 melanoma patients were included. Multivariable analysis adjusted for age, sex, melanoma stage, localization and subtype showed that familial melanoma, solar lentigines on head and neck, the back of hands, arms and shoulders were associated with a better relapse free survival. The presence of atypical naevi was associated with an increased risk of relapse. After Bonferroni correction, the correlation between presence of solar lentigines on the back of the hands and arms remained the most robust and significant prognostic factor for the relapse-free survival in cutaneous melanoma patients. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

45. Plasma cells in primary melanoma. Prognostic significance and possible role of IgA.

Author

UCL - SSS/DDUV - Institut de Duve, UCL - SSS/DDUV/GECE - Génétique cellulaire, UCL - (SLuc) Unité d'oncologie médicale, Bosisio, Francesca M, Wilmott, James S, Volders, Nathalie, Mercier, Marjorie, Wouters, Jasper, Stas, Marguerite, Blokx, Willeke Am, Massi, Daniela, Thompson, John F, Scolyer, Richard A, van Baren, Nicolas, van den Oord, Joost J, UCL - SSS/DDUV - Institut de Duve, UCL - SSS/DDUV/GECE - Génétique cellulaire, UCL - (SLuc) Unité d'oncologie médicale, Bosisio, Francesca M, Wilmott, James S, Volders, Nathalie, Mercier, Marjorie, Wouters, Jasper, Stas, Marguerite, Blokx, Willeke Am, Massi, Daniela, Thompson, John F, Scolyer, Richard A, van Baren, Nicolas, and van den Oord, Joost J

Abstract

Melanoma is not only one of the most immunogenic cancers but also one of the most effective cancers at subverting host immunity. The role of T lymphocytes in tumor immunity has been extensively studied in melanoma, whereas less is known about the importance of B lymphocytes. The effects of plasma cells (PCs), in particular, are still obscure. The aim of this study was to characterize pathological features and clinical outcome of primary cutaneous melanomas associated with PCs. Moreover, we investigated the origins of the melanoma-associated PCs. Finally, we studied the outcome of patients with primary melanomas with PCs. We reviewed 710 melanomas to correlate the presence of PCs with histological prognostic markers. Immunohistochemistry for CD138 and heavy and light chains was performed in primary melanomas (PM) and in loco-regional lymph nodes (LN), both metastatic and not metastatic. In three PM and nine LN with frozen material, VDJ-rearrangement was analyzed by Gene Scan Analysis. Survival analysis was performed on a group of 85 primary melanomas >2 mm in thickness. Forty-one cases (3.7%) showed clusters/sheets of PCs. PC-rich melanomas occurred at an older age and were thicker, more often ulcerated and more mitotically active (P<0.05). PCs were polyclonal and often expressed IgA in addition to IgG. In LN, clusters/sheets of IgA+ PCs were found both in the sinuses and subcapsular areas. Analysis of VDJ-rearrangements showed the IgA to be oligoclonal. Melanomas with clusters/sheets of PCs had a significantly worse survival compared with melanomas without PCs while, interestingly, melanomas with sparse PCs were associated with a better clinical outcome (P=0.002). In conclusion, melanomas with sheets/clusters of PCs are associated with worse prognosis. IgG and IgA are the isotypes predominantly produced by these PCs. IgA oligoclonality suggests an antigen-driven response that facilitates melanoma progression by a hitherto unknown mechanism.Modern Pathology advance o

Published
2016

46. Abstract 5197: Patient-derived xenograft (PDX) models of soft tissue sarcoma (STS): a preclinical platform for early drug testing

Author

Wozniak, Agnieszka, primary, Cornillie, Jasmien, additional, Gebreyohannes, Yemarshet K., additional, Boeckx, Bram, additional, Li, Haifu, additional, Van Looy, Thomas, additional, Floris, Giuseppe, additional, Wellens, Jasmien, additional, Vreys, Lise, additional, Hompes, Daphne, additional, Stas, Marguerite, additional, Sinnaeve, Friedl, additional, Lambrechts, Diether, additional, Debiec-Rychter, Maria, additional, Sciot, Raf, additional, and Schoffski, Patrick, additional

Published
2016
Full Text
View/download PDF

47. Abstract 1461: A panel of patient derived gastrointestinal stromal tumors (GIST) xenograft models for in vivo preclinical drug testing

Author

Wozniak, Agnieszka, primary, Van Looy, Thomas, additional, Floris, Giuseppe, additional, Gebreyohannes, Yemarshet K., additional, Wellens, Jasmien, additional, Li, Haifu, additional, Cornillie, Jasmien, additional, Vanleeuw, Ulla, additional, Hompes, Daphne, additional, Stas, Marguerite, additional, Debiec-Rychter, Maria, additional, Sciot, Raf, additional, and Schoffski, Patrick, additional

Published
2015
Full Text
View/download PDF

48. Abstract 1460: Establishment and characterization of a panel of patient-derived soft tissue sarcoma (STS) xenograft models for in vivo testing of novel therapeutic approaches

Author

Li, Haifu, primary, Cornillie, Jasmien, additional, Wozniak, Agnieszka, additional, Van Looy, Thomas, additional, Gebreyohannes, Yemarshet, additional, Wellens, Jasmien, additional, Vanleeuw, Ulla, additional, Hompes, Daphne, additional, Stas, Marguerite, additional, Sinnaeve, Friedl, additional, Debiec-Rychter, Maria, additional, Sciot, Raf, additional, and Schöffski, Patrick, additional

Published
2015
Full Text
View/download PDF

49. Antitumor Immunity Triggered by Melphalan Is Potentiated by Melanoma Cell Surface–Associated Calreticulin

Author

Dudek-Perić, Aleksandra M., primary, Ferreira, Gabriela B., additional, Muchowicz, Angelika, additional, Wouters, Jasper, additional, Prada, Nicole, additional, Martin, Shaun, additional, Kiviluoto, Santeri, additional, Winiarska, Magdalena, additional, Boon, Louis, additional, Mathieu, Chantal, additional, van den Oord, Joost, additional, Stas, Marguerite, additional, Gougeon, Marie-Lise, additional, Golab, Jakub, additional, Garg, Abhishek D., additional, and Agostinis, Patrizia, additional

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results