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3. Pathological Changes Following Neoadjuvant Endocrine Therapy (NAET): A Multicentre Study of 391 Breast Cancers.

Author

Miligy, Islam M., Badr, Nahla, Stevens, Andrea, Spooner, David, Awasthi, Rachna, Mir, Yasmeen, Khurana, Anuj, Sharma, Vijay, Chandaran, Usha, Rakha, Emad A., Maurice, Yasmine, Kearns, Daniel, Oweis, Rami, Asar, Amal, Ironside, Alastair, and Shaaban, Abeer M.

Subjects
HORMONE therapy, NEOADJUVANT chemotherapy, PATHOLOGICAL physiology, BREAST cancer, TUMOR-infiltrating immune cells, EPIDERMAL growth factor receptors, BREAST, HEART beat
Abstract

Oestrogen receptor (ER)-positive breast cancer (BC) is generally well responsive to endocrine therapy. Neoadjuvant endocrine therapy (NAET) is increasingly being used for downstaging ER-positive tumours. This study aims to analyse the effect of NAET on a well-characterised cohort of ER-positive BC with particular emphasis on receptor expression. This is a retrospective United Kingdom (UK) multicentre study of 391 patients who received NAET between October 2012 and October 2020. Detailed analyses of the paired pre- and post-NAET morphological changes and hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) expression were performed. The median duration of NAET was 86 days, with median survival and overall survival rates of 380 days and 93.4%, respectively. A total of 90.3% of cases achieved a pathological partial response, with a significantly higher rate of response in the HER2-low cancers. Following NAET, BC displayed some pathological changes involving the tumour stroma including central scarring and an increase in tumour infiltrating lymphocytes (TILs) and tumour cell morphology. Significant changes associated with the duration of NAET were observed in tumour grade (30.6% of cases), with downgrading identified in 19.3% of tumours (p < 0.001). The conversion of ER status from positive to low or negative was insignificant. The conversion of progesterone receptor (PR) and HER2 status to negative status was observed in 31.3% and 38.1% of cases, respectively (p < 0.001). HER2-low breast cancer decreased from 63% to 37% following NAET in the paired samples. Significant morphological and biomarker changes involving PR and HER2 expression occurred following NAET. The findings support biomarker testing on pre-treatment core biopsies and post-treatment residual carcinoma. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Quality of life after breast-conserving therapy and adjuvant radiotherapy for non-low-risk ductal carcinoma in situ (BIG 3-07/TROG 07.01): 2-year results of a randomised, controlled, phase 3 trial

Author

Chua, Boon H, Phillips, Claire, Bryant, Guy, Westenberg, Helen, Purohit, Om Pra-Kesh, Ahern, Verity, Graham, Peter, Akra, Mohamed, McArdle, Orla, O'Brien, Peter, Ludbrook, Jane, Harvey, Jennifer, Maduro, John H, Gabelle-Flandin, Isabelle, Kirkove, Carine, Bedi, Carolyn, Martin, Joseph, Vu, Tony, Muanza, Theirry, Neal, Anthony, Courdi, Adel, Thariat, Juliette, Rakovitch, Eileen, Daniels, Laurien, van Hezewijk, Marjan, Cwajna, Wlasyslawa, Roelstraete, Adelheid, van Baardwijk, Angela, Russel, Nicola, Koch, Anne, Croke, Jennifer, Locke, Imogen, Jeal, Peter, Walker, Quenten, Thuraisingham, Kandeepeepan, Chauduri, Anupam, Joseph, David, Taylor, Mandy, Vanderkam, Sabine, Woo, Tony, Tang, Johann, Yassa, Michael, Wai, Elaine, Hewitt, Susan, Mahmood, Shazia, Gilmore, Jennifer, Ofi, Bolante, Bahl, Amit, Vujovic, Olga, Yu, Edward, Le, Duc, Kong, Iwa, Nichol, Alan, Bijker, Nina, Delaney, Geoff, Feigen, Malcolm, Lim, Adeline, Chao, Michael, Latham, Margaret, Algurafi, Hafiz, Tausch, Christoph, Khoo, Eric, Leung, Sam, Taylor, Karen, Senthi, Sasha, Stevens, Andrea, Chaudhuri, Abhro, Cleator, Susan, Brunt, Adrian Murray, Babington, Scott, Christie, David, Zwahlen, Daniel, Schratzenstaller, Ulrich, Masson, Laurence, Storey, Nicola, Kumar, Eshwar, Sherwin, Liz, Weytjens, Reinhilde, Ravi, Sharma, Lawton, Patricia, Angell, Ruth, Round, Glenys, Allen, Angela, Thotathil, Ziad, Anthes, Margaret, Reuter, Christiane, Pettit, Laura, Zissiadis, Yvonne, Elder, Christine, Verbeek-de Kanter, Antoinette, Lirette, Andree, Plasswilm, Ludwig, Spooner, David, Hoar, Fiona, Mohamed, Islam, Lossl, Kristina, Loo, Vivienne, Richetti, Antonella, Evans, Tamasin, Hennessy, Aisling, El-Mallah, Medhat, Skala, Marketa, Awad, Raef, Germain, Isabelle, Mitine, Carine, Van Parijs, Hilde, Churn, Mark, Walji, Nawaz, Francis, Michael, Stellamans, Karin, Gruber, Gunther, Ivaldi, Giovanni, Alhasso, Abdulla, Kenny, Lizbeth, Tiver, Ken, Griffin, Matthew, Lamoury, Gillian, Trovo, Marco, Algufarfi, Hafiz, Lah, Minjae, Carruthers, Scott, Papadatos, George, Paardekooper, Gabriel, Persic, Mojca, Lavery, Bernadette, King, Madeleine T, Link, Emma K, Whelan, Tim J, Olivotto, Ivo A, Kunkler, Ian, Westenberg, Antonia Helen, Gruber, Guenther, and Schofield, Penny

Published
2020
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24. Listado anotado de Solanum L

Author

Särkinen, Tiina, Baden, Maria, Gonzáles, Paúl, Cueva, Marco, Giacomin, Leandro L., Spooner, David M., Simon, Reinhard, Juárez, Henry, Nina, Pamela, Molina, Johanny, and Knapp, Sandra

Published
2015
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25. Characterization of the Immune Microenvironment in Inflammatory Breast Cancer Using Multiplex Immunofluorescence

Author

Badr, Nahla M., primary, McMurray, Jack L., additional, Danial, Irini, additional, Hayward, Steven, additional, Asaad, Nancy Y., additional, Abd El-Wahed, Moshira M., additional, Abdou, Asmaa G., additional, Serag El-Dien, Marwa M., additional, Sharma, Nisha, additional, Horimoto, Yoshiya, additional, Sircar, Tapan, additional, Vidya, Raghavan, additional, Hoar, Fiona, additional, Rea, Daniel, additional, Jones, J. Louise, additional, Stevens, Andrea, additional, Spooner, David, additional, Merard, Reena, additional, Lewis, Paul, additional, Hunter, Kelly John, additional, Berditchevski, Fedor, additional, and Shaaban, Abeer M., additional

Published
2022
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28. Walking for Wellness: “Feeling Maps” Can Help Planners to Create Campus Routes that Improve Student WellBeing.

Author

Spooner, David

Subjects
STUDENT well-being, COLLEGE campuses, HEALTH facilities, MENTAL health, PHYSICAL sciences research, WALKABILITY
Abstract

The article focuses on the use of "feeling maps" by planners at the University of Georgia to create healthier connections and improve student well-being on campus. It mentions that the research explores the correlation between walking routes and positive emotions, emphasizing the mental health benefits of walking and the importance of sensory pleasure and a sense of belonging in creating a positive walking experience.

Published
2023

29. Characterization of the Immune Microenvironment in Inflammatory Breast Cancer Using Multiplex Immunofluorescence.

Author

Badr, Nahla M., McMurray, Jack L., Danial, Irini, Hayward, Steven, Asaad, Nancy Y., Abd El-Wahed, Moshira M., Abdou, Asmaa G., Serag El-Dien, Marwa M., Sharma, Nisha, Horimoto, Yoshiya, Sircar, Tapan, Vidya, Raghavan, Hoar, Fiona, Rea, Daniel, Jones, J. Louise, Stevens, Andrea, Spooner, David, Merard, Reena, Lewis, Paul, and Hunter, Kelly John

Published
2023
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30. Potato

Author

Jansky, Shelley H., primary, Spooner, David M., additional, and Bethke, Paul C., additional

Published
2015
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33. Subspecies Variation of Daucus carota Coastal (“Gummifer”) Morphotypes (Apiaceae) Using Genotyping-by-Sequencing

Author

Universidad de Alicante. Departamento de Ciencias Ambientales y Recursos Naturales, Martínez Flores, Fernando, Crespo, Manuel B., Simon, Philipp W., Ruess, Holly, Reitsma, Kathleen, Geoffriau, Emmanuel, Allender, Charlotte, Mezghani, Najla, Spooner, David M., Universidad de Alicante. Departamento de Ciencias Ambientales y Recursos Naturales, Martínez Flores, Fernando, Crespo, Manuel B., Simon, Philipp W., Ruess, Holly, Reitsma, Kathleen, Geoffriau, Emmanuel, Allender, Charlotte, Mezghani, Najla, and Spooner, David M.

Abstract

The genus Daucus is widely distributed worldwide, but with a concentration of diversity in the Mediterranean Region. The D. carota complex presents the greatest taxonomic problems in the genus. We focus on a distinctive phenotypic group of coastal morphotypes of D. carota, strictly confined to the margins to within about 0.5 km of the Mediterranean Sea and the Atlantic Ocean, which we here refer to as coastal morphotypes or D. carota subsp. “gummifer” complex. They are loosely morphologically coherent, sharing a relatively short stature, thick, broad, sometimes highly glossy leaf segments, and usually flat or convex fruiting umbels. We analyzed 288 accessions obtained from genebanks in England, France, and the USA, and an expedition to Spain in 2016, covering the Mediterranean and Atlantic coasts and Balearic Islands, where much of the gummifer complex variation occurs. Our study includes 112 accessions not examined before in this context. Genotyping-by-sequencing identified 29,041 filtered SNPs. Based on high bootstrap support from maximum likelihood and Structure analysis we highlight three main clades. The gummifer morphotypes are intercalated with members of Daucus carota subspecies carota and subspecies maximus in two of these main clades, including a clade containing accessions from Tunisia (also including D. carota subsp. capillifolius) and a clade containing accessions from western Europe (including the British Isles), southern Europe (including the Balearic Islands and the Iberian Peninsula) and Morocco. These results support five independent selections of the gummifer morphotypes in these restricted maritime environments in the Mediterranean and nearby Atlantic coasts. Daucus annuus (=Tornabenea annua) and Daucus tenuissimus (=Tornabenea tenuissima) also fall firmly within D. carota, supporting their classification as morphologically well-defined subspecies of D. carota, which are accepted here under the new combinations Daucus carota subsp. annuus and D.

Published
2020

37. Quality of life after breast-conserving therapy and adjuvant radiotherapy for non-low-risk ductal carcinoma in situ (BIG 3-07/TROG 07.01): 2-year results of a randomised, controlled, phase 3 trial

Author

King, Madeleine T, primary, Link, Emma K, additional, Whelan, Tim J, additional, Olivotto, Ivo A, additional, Kunkler, Ian, additional, Westenberg, Antonia Helen, additional, Gruber, Guenther, additional, Schofield, Penny, additional, Chua, Boon H, additional, Phillips, Claire, additional, Bryant, Guy, additional, Westenberg, Helen, additional, Purohit, Om Pra-Kesh, additional, Ahern, Verity, additional, Graham, Peter, additional, Akra, Mohamed, additional, McArdle, Orla, additional, O'Brien, Peter, additional, Ludbrook, Jane, additional, Harvey, Jennifer, additional, Maduro, John H, additional, Gabelle-Flandin, Isabelle, additional, Kirkove, Carine, additional, Bedi, Carolyn, additional, Martin, Joseph, additional, Vu, Tony, additional, Muanza, Theirry, additional, Neal, Anthony, additional, Courdi, Adel, additional, Thariat, Juliette, additional, Rakovitch, Eileen, additional, Daniels, Laurien, additional, van Hezewijk, Marjan, additional, Cwajna, Wlasyslawa, additional, Roelstraete, Adelheid, additional, van Baardwijk, Angela, additional, Russel, Nicola, additional, Koch, Anne, additional, Croke, Jennifer, additional, Locke, Imogen, additional, Jeal, Peter, additional, Walker, Quenten, additional, Thuraisingham, Kandeepeepan, additional, Chauduri, Anupam, additional, Joseph, David, additional, Taylor, Mandy, additional, Vanderkam, Sabine, additional, Woo, Tony, additional, Tang, Johann, additional, Yassa, Michael, additional, Wai, Elaine, additional, Hewitt, Susan, additional, Mahmood, Shazia, additional, Gilmore, Jennifer, additional, Ofi, Bolante, additional, Bahl, Amit, additional, Vujovic, Olga, additional, Yu, Edward, additional, Le, Duc, additional, Kong, Iwa, additional, Nichol, Alan, additional, Bijker, Nina, additional, Delaney, Geoff, additional, Feigen, Malcolm, additional, Lim, Adeline, additional, Chao, Michael, additional, Latham, Margaret, additional, Algurafi, Hafiz, additional, Tausch, Christoph, additional, Khoo, Eric, additional, Leung, Sam, additional, Taylor, Karen, additional, Senthi, Sasha, additional, Stevens, Andrea, additional, Chaudhuri, Abhro, additional, Cleator, Susan, additional, Brunt, Adrian Murray, additional, Babington, Scott, additional, Christie, David, additional, Zwahlen, Daniel, additional, Schratzenstaller, Ulrich, additional, Masson, Laurence, additional, Storey, Nicola, additional, Kumar, Eshwar, additional, Sherwin, Liz, additional, Weytjens, Reinhilde, additional, Ravi, Sharma, additional, Lawton, Patricia, additional, Angell, Ruth, additional, Round, Glenys, additional, Allen, Angela, additional, Thotathil, Ziad, additional, Anthes, Margaret, additional, Reuter, Christiane, additional, Pettit, Laura, additional, Zissiadis, Yvonne, additional, Elder, Christine, additional, Verbeek-de Kanter, Antoinette, additional, Lirette, Andree, additional, Plasswilm, Ludwig, additional, Spooner, David, additional, Hoar, Fiona, additional, Mohamed, Islam, additional, Lossl, Kristina, additional, Loo, Vivienne, additional, Richetti, Antonella, additional, Evans, Tamasin, additional, Hennessy, Aisling, additional, El-Mallah, Medhat, additional, Skala, Marketa, additional, Awad, Raef, additional, Germain, Isabelle, additional, Mitine, Carine, additional, Van Parijs, Hilde, additional, Churn, Mark, additional, Walji, Nawaz, additional, Francis, Michael, additional, Stellamans, Karin, additional, Gruber, Gunther, additional, Ivaldi, Giovanni, additional, Alhasso, Abdulla, additional, Kenny, Lizbeth, additional, Tiver, Ken, additional, Griffin, Matthew, additional, Lamoury, Gillian, additional, Trovo, Marco, additional, Algufarfi, Hafiz, additional, Lah, Minjae, additional, Carruthers, Scott, additional, Papadatos, George, additional, Paardekooper, Gabriel, additional, Persic, Mojca, additional, and Lavery, Bernadette, additional

Published
2020
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38. Synchronous versus sequential chemo-radiotherapy in patients with early stage breast cancer (SECRAB): A randomised, phase III, trial

Author

Fernando, Indrajit N., primary, Bowden, Sarah J., additional, Herring, Kathryn, additional, Brookes, Cassandra L., additional, Ahmed, Ikhlaaq, additional, Marshall, Andrea, additional, Grieve, Robert, additional, Churn, Mark, additional, Spooner, David, additional, Latief, Talaat N., additional, Agrawal, Rajiv K., additional, Brunt, Adrian M., additional, Stevens, Andrea, additional, Goodman, Andrew, additional, Canney, Peter, additional, Bishop, Jill, additional, Ritchie, Diana, additional, Dunn, Janet, additional, Poole, Christopher J., additional, and Rea, Daniel W., additional

Published
2020
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39. Additional file 4: Figure S2. of Genotyping-by-sequencing provides the discriminating power to investigate the subspecies of Daucus carota (Apiaceae)

Author

Arbizu, Carlos, Ellison, Shelby, Senalik, Douglas, Simon, Philipp, and Spooner, David

Abstract

Phylogenomics of Daucus from a maximum likelihood analysis using 164 accessions and 38,920 SNPs (30% missing imputed genotypes) obtained by GBS. Numbers above branches represent bootstrap values, with only values higher than 70% shown. Names given to clades refer to the geographic origin and improvement status of the accessions of the D. carota complex. Clades A and B corresponds to the two main groups of the Daucus phylogeny. (PDF 1.34 mb)

Published
2019
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40. Additional file 7: Figure S5. of Genotyping-by-sequencing provides the discriminating power to investigate the subspecies of Daucus carota (Apiaceae)

Author

Arbizu, Carlos, Ellison, Shelby, Senalik, Douglas, Simon, Philipp, and Spooner, David

Abstract

Relationships among 144 accessions of the Daucus carota complex and outgroups from an exhaustive quartet sampling inference using 18,565 SNPs (10Â % missing imputed genotypes) obtained by GBS. Numbers above the branches represent bootstrap values, with only values higher than 70Â % shown. Names given to clades refer to the geographic origin and improvement status of the accessions of the D. carota complex. ME & E refers to Middle East & Europe. Accessions designated by double stars are misplaced relative to the maximum likelihood topology of the Daucus carota complex using the same number of SNPs. The outgroup taxon is D. syrticus. (PDF 1 MB)

Published
2019
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41. Additional file 10: Figure S8. of Genotyping-by-sequencing provides the discriminating power to investigate the subspecies of Daucus carota (Apiaceae)

Author

Arbizu, Carlos, Ellison, Shelby, Senalik, Douglas, Simon, Philipp, and Spooner, David

Abstract

Number of populations. A. Plot of Delta K (Î K). B. Plot of the log likelihood; internal plot corresponds to the log likelihood (thousands) for K ranging from 1 to 9. All values were obtained from STRUCTURE HARVESTER analysis. Fourteen populations were considered in a data set of 18,565 SNPs (10Â % missing imputed genotypes) and 150 samples. (PDF 893 kb)

Published
2019
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42. Additional file 9: Figure S7. of Genotyping-by-sequencing provides the discriminating power to investigate the subspecies of Daucus carota (Apiaceae)

Author

Arbizu, Carlos, Ellison, Shelby, Senalik, Douglas, Simon, Philipp, and Spooner, David

Abstract

Species tree of the Daucus carota complex based on a coalescent model using an exhaustive quartet sampling inference and 18,565 SNPs (10% missing imputed genotypes) obtained by GBS. Numbers above the branches represent bootstrap values. The outgroup taxon is D. syrticus. (PDF 104 kb)

Published
2019
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44. Additional file 6: Figure S4. of Genotyping-by-sequencing provides the discriminating power to investigate the subspecies of Daucus carota (Apiaceae)

Author

Arbizu, Carlos, Ellison, Shelby, Senalik, Douglas, Simon, Philipp, and Spooner, David

Abstract

Bayesian phylogenetic tree of 144 accessions of the Daucus carota complex and outgroups using 18,565 SNPs (10% missing imputed genotypes) obtained by GBS. Numbers above the branches represent posterior probabilities, with only values higher than 0.7 shown. Names given to clades refer to the geographic origin and improvement status of the accessions of the D. carota complex. The outgroup taxon is D. syrticus. (PDF 1.33 mb)

Published
2019
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45. Additional file 3: Figure S1. of Genotyping-by-sequencing provides the discriminating power to investigate the subspecies of Daucus carota (Apiaceae)

Author

Arbizu, Carlos, Ellison, Shelby, Senalik, Douglas, Simon, Philipp, and Spooner, David

Abstract

Phylogenomics of Daucus from a maximum likelihood analysis using 164 accessions and 10,814 SNPs (10Â % missing imputed genotypes) obtained by GBS. Numbers above branches represent bootstrap values, with only values higher than 70Â % shown. Names given to clades refer to the geographic origin and improvement status of the accessions of the D. carota complex. Clades A and B corresponds to the two main groups of the Daucus phylogeny. (PDF 1 MB)

Published
2019
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46. Extended studies of interspecific relationships in Daucus (Apiaceae) using DNA sequences from ten nuclear orthologues

Author

Universidad de Alicante. Departamento de Ciencias Ambientales y Recursos Naturales, Martínez Flores, Fernando, Crespo, Manuel B., Geoffriau, Emmanuel, Allender, Charlotte, Ruess, Holly, Arbizu, Carlos I., Simon, Philipp, Spooner, David M., Universidad de Alicante. Departamento de Ciencias Ambientales y Recursos Naturales, Martínez Flores, Fernando, Crespo, Manuel B., Geoffriau, Emmanuel, Allender, Charlotte, Ruess, Holly, Arbizu, Carlos I., Simon, Philipp, and Spooner, David M.

Abstract

Daucus has traditionally been estimated to comprise 21–25 species, but a recent study expanded the genus to c. 40 species. The present study uses ten nuclear orthologues to examine 125 accessions, including 40 collections of 11 species (D. annuus, D. arcanus, D. decipiens, D. durieua, D. edulis, D. gracilis, D. minusculus, D. montanus, D. pumilus, D. setifolius and D. tenuissimus) newly examined with nuclear orthologues. As in previous nuclear orthologue studies, Daucus resolves into two well-defined clades, and groups different accessions of species together. Maximum likelihood and maximum parsimony analyses provide concordant results, but SVD quartets reveals many areas of disagreement of species within these two major clades. With maximum likelihood and maximum parsimony analyses Daucus montanus (hexaploid) is resolved as an allopolyploid between D. pusillus (diploid) and D. glochidiatus (tetraploid), whereas with SVD quartets it is resolved as an allopolyploid between D. glochidiatus and an unknown Daucus sp. We propose the new combination Daucus junceus (Durieua juncea) for a neglected species endemic to the south-western Iberian Peninsula often referred to as D. setifolius, and we place D. arcanus in synonymy with D. pusillus. Three lectotypes are also designated.

Published
2019

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