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111 results on '"Spiazzi, L."'

7. How has prostate cancer radiotherapy changed in Italy between 2004 and 2011? An analysis of the national patterns-of-practice (pop) database by the uro-oncology study group of the italian society of radiotherapy and clinical oncology (airo)

Author

Mazzeo, E, Triggiani, L, Frassinelli, L, Guarneri, A, Bartoncini, S, Antognoni, P, Gottardo, S, Greco, D, Borghesi, S, Nanni, S, Bruni, A, Ingrosso, G, D'Angelillo, R, Detti, B, Francolini, G, Magli, A, Guerini, A, Arcangeli, S, Spiazzi, L, Ricardi, U, Lohr, F, Magrini, S, Mazzeo E., Triggiani L., Frassinelli L., Guarneri A., Bartoncini S., Antognoni P., Gottardo S., Greco D., Borghesi S., Nanni S., Bruni A., Ingrosso G., D'angelillo R. M., Detti B., Francolini G., Magli A., Guerini A. E., Arcangeli S., Spiazzi L., Ricardi U., Lohr F., Magrini S. M., Mazzeo, E, Triggiani, L, Frassinelli, L, Guarneri, A, Bartoncini, S, Antognoni, P, Gottardo, S, Greco, D, Borghesi, S, Nanni, S, Bruni, A, Ingrosso, G, D'Angelillo, R, Detti, B, Francolini, G, Magli, A, Guerini, A, Arcangeli, S, Spiazzi, L, Ricardi, U, Lohr, F, Magrini, S, Mazzeo E., Triggiani L., Frassinelli L., Guarneri A., Bartoncini S., Antognoni P., Gottardo S., Greco D., Borghesi S., Nanni S., Bruni A., Ingrosso G., D'angelillo R. M., Detti B., Francolini G., Magli A., Guerini A. E., Arcangeli S., Spiazzi L., Ricardi U., Lohr F., and Magrini S. M.

Abstract

Background and purpose: Two previous “Patterns Of Practice” surveys (POP I and POP II), including more than 4000 patients affected by prostate cancer treated with radical external beam radiotherapy (EBRT) between 1980 and 2003, established a “benchmark” Italian data source for prostate cancer radiotherapy. This report (POP III) updates the previous studies. Methods: Data on clinical management and outcome of 2525 prostate cancer patients treated by EBRT from 2004 to 2011 were collected and compared with POP II and, when feasible, also with POP I. This report provides data on clinical presentation, diagnostic workup, radiation therapy management, and toxicity as collected within the framework of POP III. Results: More than 50% of POP III patients were classified as low or intermediate risk using D’Amico risk categories as in POP II; 46% were classified as ISUP grade group 1. CT scan, bone scan, and endorectal ultrasound were less frequently prescribed. Dose-escalated radiotherapy (RT), intensity modulated radiotherapy (IMRT), image guided radiotherapy (IGRT), and hypofractionated RT were more frequently offered during the study period. Treatment was commonly well tolerated. Acute toxicity improved compared to the previous series; late toxicity was influenced by prescribed dose and treatment technique. Five-year overall survival, biochemical relapse free survival (BRFS), and disease specific survival were similar to those of the previous series (POP II). BRFS was better in intermediate-and high-risk patients treated with ≥ 76 Gy. Conclusions: This report highlights the improvements in radiotherapy planning and dose delivery among Italian Centers in the 2004–2011 period. Dose-escalated treatments resulted in better biochemical control with a reduction in acute toxicity and higher but acceptable late toxicity, as not yet comprehensively associated with IMRT/IGRT. CTV-PTV margins >8 mm were associated with increased toxicity, again suggesting that IGRT—allowing for ti

Published
2021

9. PO-1347 Prostate cancer RT pattern of practice in Italy between 2004-2011: an analysis by the AIRO database

Author

Bruni, A., primary, Mazzeo, E., additional, Triggiani, L., additional, Frassinelli, L., additional, Guarneri, A., additional, Bartoncini, S., additional, Antognoni, P., additional, Gottardo, S., additional, Greco, D., additional, Borghesi, S., additional, Nanni, S., additional, Ingrosso, G., additional, D’Angelillo, R.M., additional, Detti, B., additional, Francolini, G., additional, Magli, A., additional, Guerini, A., additional, Arcangeli, S., additional, Spiazzi, L., additional, Ricardi, U., additional, Lohr, F., additional, and Magrini, S.M., additional

Published
2021
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16. A randomized split-face clinical trial of conventional vs indoor-daylight photodynamic therapy for the treatment of multiple actinic keratosis of the face and scalp and photoaging.

Author

Arisi, M., Rossi, M. T., Spiazzi, L., Guasco Pisani, E., Venturuzzo, A., Rovati, C., Tomasi, C., Venturini, M., and Calzavara-Pinton, P. G.

Subjects
ACTINIC keratosis, PHOTODYNAMIC therapy, CLINICAL trials, SCALP, LED lamps, TREATMENT effectiveness
Abstract

Recently, indoor daylight photodynamic therapy (idl-PDT) has been developed; however, its efficacy and tolerability remain to be assessed. This is a not-inferiority study to compare treatment outcomes of cPDT with a red LED lamp and idlPDT with a polychromatic white LED lamp in adult patients affected by symmetrical AKs of face and/or scalp. In this comparative, intra-patient, split-face, randomized clinical trial forty-three adult patients were enrolled. Two contralateral and symmetrical target areas of the face and/or scalp harboring at least 5 AKs were selected and randomized 1:1 to treatment with cPDT and idlPDT. The AKs number and cumulative area were assessed at baseline (T0). Efficacy and cosmetic outcome were assessed 3 months after treatment (T1). Total AKs number and area reduced significantly with both idlPDT (p <.0001) and cPDT (p <.0001) in comparison to baseline. cPDT was more painful (p <.0001) and induced a more severe inflammation (p <.0001). Twenty-nine patients (70.7%) gave their overall preference to idlPDT (p <.001). idlPDT may represent an alternative treatment protocol to cPDT for in-office treatment of AKs patients with better tolerability and a not inferior efficacy. [ABSTRACT FROM AUTHOR]

Published
2022
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18. PO-1022: Clinical-dosimetric assessment with Prodvh software after adjuvant radiotherapy for MPM

Author

Salah ElDin Tantawi, E., primary, Borghetti, P., additional, Cozzaglio, C., additional, Bonù, M., additional, Pasinetti, N., additional, Greco, D., additional, Maddalo, M., additional, Baiguini, A., additional, Vitali, P., additional, Ranghetti, E., additional, Guerini, A., additional, Buglione, M., additional, Spiazzi, L., additional, and Magrini, S.M., additional

Published
2020
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20. PO-0843: Assessment of weight loss and subjective dysphagia after radiotherapy for head and neck cancer

Author

Maddalo, M., primary, Costantino, G., additional, Buglione, M., additional, Spiazzi, L., additional, Volpi, G., additional, Premi, A., additional, Donofrio, A., additional, Guerini, A., additional, Alghisi, A., additional, Pedretti, S., additional, Costa, L., additional, Greco, D., additional, Cominardi, C., additional, Pegurri, L., additional, and Magrini, S.M., additional

Published
2020
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21. PO-1572: Use of intravoxel incoherent motion (IVIM) MRI for predicting dysphagia in oropharyngeal carcinoma

Author

Maddalo, M., primary, Altabella, L., additional, Pegurri, L., additional, Guerini, A., additional, Peretto, G., additional, Alghisi, A., additional, Turla, O., additional, Guaineri, A., additional, Costantino, G., additional, Spiazzi, L., additional, Costa, L., additional, Mozzetti, C., additional, Pasinetti, N., additional, and Buglione, M., additional

Published
2020
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24. 45 Threshold dose for focal liver reaction

Author

Spiazzi, L., primary, Toraci, C., additional, Frassine, F., additional, Borghetti, P., additional, Altabella, L., additional, Vitali, P., additional, Polonini, A., additional, and Moretti, R, additional

Published
2018
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28. Small beam dosimetry: A multi-center multi-detector italian project

Author

Talamonti, C., primary, Russo, S., additional, Barone, Tonghi L., additional, Benecchi, G., additional, Borzi, G., additional, Bresciani, S., additional, Cagni, E, additional, Carbonino, C., additional, Casale, M., additional, Clemente, S., additional, Consorti, R., additional, D’Alessio, V., additional, Dicastro, E., additional, Donofrio, G., additional, Falco, M.D., additional, Fedele, D., additional, Fiandra, C., additional, Frassanito, C., additional, Gasperi, C., additional, Giglioli, F.R., additional, Iervolino, C., additional, Infusino, E., additional, Linsalata, S., additional, Loi, G., additional, Lorenzini, E., additional, Marino, C., additional, Martinotti, S., additional, Masi, L., additional, Menghi, E., additional, Miceli, R., additional, Moretti, E., additional, Nardiello, B., additional, Nigro, R., additional, Pastore, G., additional, Pressello, M.C., additional, Pimpinella, M., additional, Raza, G., additional, Rosica, F., additional, Ruggeri, R., additional, Spiazzi, L., additional, Stasi, M., additional, Strigari, L., additional, Tremolada, V., additional, Vaiano, A., additional, Vigorito, S., additional, Villaggi, E., additional, Vittorini, F., additional, and Mancosu, P., additional

Published
2016
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29. Dosimetric characterization of linac small beams using a plastic scintillator detector: A multicenter study

Author

Pasquino, M., primary, Stasi, M., additional, Mancosu, P., additional, Russo, S., additional, Villaggi, E., additional, Gasperi, C., additional, Casale, M,., additional, Loi, G., additional, Strigari, L., additional, Miceli, R., additional, Raza, G.H., additional, Fedele, D., additional, Vaiano, A., additional, Falco, M.D., additional, Moretti, E., additional, Giglioli, F.R., additional, Nigro, R., additional, Talamonti, C., additional, Pastore, G., additional, Luxardo, S., additional, Menghi, E., additional, Benecchi, G., additional, Clemente, S., additional, Marino, C., additional, Borzi, G., additional, Nardiello, B., additional, Ardu, V., additional, Paladini, L., additional, Cagni, E., additional, Russo, G., additional, Spiazzi, L., additional, and Vittorini, F., additional

Published
2016
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30. Small field relative dosimetry using a silicon diode of new generation

Author

Talamonti, C., primary, Falco, M.D., additional, Bartoli, A., additional, Russo, S., additional, Iervolino, C., additional, Menghi, E., additional, Moretti, E., additional, Mones, E., additional, Fiandra, C., additional, Casale, M., additional, Pastore, G., additional, Oliviero, C., additional, DiCastro, E., additional, Luxardo, S., additional, Vaiano, A., additional, Raza, G.H., additional, Borzi, G., additional, Carbonini, C., additional, Consorti, R., additional, Pressello, M.C., additional, Gasperi, C., additional, Tonghi, L. Barone, additional, Palleri, F., additional, Marino, C., additional, Ardu, V., additional, Linsalata, S., additional, Riccardi, S., additional, Vittorini, F., additional, Spiazzi, L., additional, Rosica, F., additional, Villaggi, E., additional, and Mancosu, P., additional

Published
2016
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32. PV-0226: Pattern of relapse of glioblastoma treated with Stupp protocol:could a margin reduction be proposed?

Author

Pedretti, S., primary, Buglione, M., additional, Borghetti, P., additional, Costa, L., additional, Triggiani, L., additional, Pegurri, L., additional, Ghirardelli, P., additional, Foscarini, F., additional, Pandini, S., additional, Spiazzi, L., additional, Tesini, G., additional, Uccelli, C., additional, Saiani, F., additional, and Magrini, S., additional

Published
2016
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33. EP-1948: Multicentre comparison for small field dosimetry using the new silicon diode RAZOR

Author

Talamonti, C., primary, Falco, M.D., additional, Barone Tonghi, L., additional, Benecchi, G., additional, Carbonini, C., additional, Casale, M., additional, Clemente, S., additional, Consorti, R., additional, Di Castro, E., additional, Esposito, M., additional, Fiandra, C., additional, Gasperi, C., additional, Iervolino, C., additional, Luxardo, S., additional, Marino, C., additional, Mones, E., additional, Oliviero, C., additional, Pressello, M.C., additional, Riccardi, S., additional, Rosica, F., additional, Spiazzi, L., additional, Stasi, M., additional, Strigari, L., additional, Mancosu, P., additional, and Russo, S., additional

Published
2016
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39. Multicenter evaluation of the dosimetric characterization of linac small beams using a plastic scintillator detector

Author

Mancosu, P., primary, Ardu, V., additional, Benecchi, G., additional, Gasperri, C., additional, Linsalata, S., additional, Loi, G., additional, Menghi, E., additional, Mones, E., additional, Nigro, R., additional, Palleri, F., additional, Pasquino, M., additional, Pellegrini, C., additional, Riccardi, S., additional, Spiazzi, L., additional, and Stasi, M., additional

Published
2016
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47. The potential role of SPECT/CT in the clinical management of COVID-19 lung cancer patients undergoing radiotherapy

Author

Cristian Toraci, Jessica Imbrescia, Andrea Emanuele Guerini, Alessandro Magli, Salvatore Cappabianca, Luigi Spiazzi, Silvia Lucchini, Giulia Volpi, Alfonso Reginelli, Valerio Nardone, Paolo Borghetti, Stefano Maria Magrini, Borghetti, P., Toraci, C., Imbrescia, J., Volpi, G., Lucchini, S., Guerini, A. E., Magli, A., Spiazzi, L., Reginelli, A., Cappabianca, S., Magrini, S. M., and Nardone, V.

Subjects
Oncology, medicine.medical_specialty, 2019-20 coronavirus outbreak, Single Photon Emission Computed Tomography Computed Tomography, Lung Neoplasms, Coronavirus disease 2019 (COVID-19), SARS-CoV-2, business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), medicine.medical_treatment, MEDLINE, COVID-19, General Medicine, medicine.disease, Radiation therapy, Internal medicine, medicine, Radiology, Nuclear Medicine and imaging, Lung cancer, business, Human
Published
2021
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48. How Has Prostate Cancer Radiotherapy Changed in Italy between 2004 and 2011? An Analysis of the National Patterns-Of-Practice (POP) Database by the Uro-Oncology Study Group of the Italian Society of Radiotherapy and Clinical Oncology (AIRO)

Author

Stefania Gottardo, Diana Greco, Simona Borghesi, Beatrice Detti, Gianluca Ingrosso, Paolo Antognoni, Umberto Ricardi, Alessandro Magli, Stefano Maria Magrini, Ercole Mazzeo, Luigi Spiazzi, Andrea Emanuele Guerini, Luca Frassinelli, Sara Nanni, Sara Bartoncini, Frank Lohr, Alessio Bruni, Rolando Maria D'Angelillo, Giulio Francolini, Stefano Arcangeli, Alessia Guarneri, Luca Triggiani, Mazzeo, E, Triggiani, L, Frassinelli, L, Guarneri, A, Bartoncini, S, Antognoni, P, Gottardo, S, Greco, D, Borghesi, S, Nanni, S, Bruni, A, Ingrosso, G, D'Angelillo, R, Detti, B, Francolini, G, Magli, A, Guerini, A, Arcangeli, S, Spiazzi, L, Ricardi, U, Lohr, F, and Magrini, S

Subjects
0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, genetic structures, medicine.medical_treatment, behavioral disciplines and activities, Article, Settore MED/06, Pattern Of Practice, Late toxicity, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, Settore MED/36, Internal medicine, medicine, External beam radiotherapy, RC254-282, radiotherapy, Image-guided radiation therapy, Clinical Oncology, Radiotherapy, urogenital system, business.industry, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, prostate cancer, Acute toxicity, body regions, Radiation therapy, 030104 developmental biology, 030220 oncology & carcinogenesis, Toxicity, business, psychological phenomena and processes
Abstract

Background and purpose: Two previous “Patterns Of Practice” surveys (POP I and POP II), including more than 4000 patients affected by prostate cancer treated with radical external beam radiotherapy (EBRT) between 1980 and 2003, established a “benchmark” Italian data source for prostate cancer radiotherapy. This report (POP III) updates the previous studies. Methods: Data on clinical management and outcome of 2525 prostate cancer patients treated by EBRT from 2004 to 2011 were collected and compared with POP II and, when feasible, also with POP I. This report provides data on clinical presentation, diagnostic workup, radiation therapy management, and toxicity as collected within the framework of POP III. Results: More than 50% of POP III patients were classified as low or intermediate risk using D’Amico risk categories as in POP II, 46% were classified as ISUP grade group 1. CT scan, bone scan, and endorectal ultrasound were less frequently prescribed. Dose-escalated radiotherapy (RT), intensity modulated radiotherapy (IMRT), image guided radiotherapy (IGRT), and hypofractionated RT were more frequently offered during the study period. Treatment was commonly well tolerated. Acute toxicity improved compared to the previous series, late toxicity was influenced by prescribed dose and treatment technique. Five-year overall survival, biochemical relapse free survival (BRFS), and disease specific survival were similar to those of the previous series (POP II). BRFS was better in intermediate- and high-risk patients treated with ≥ 76 Gy. Conclusions: This report highlights the improvements in radiotherapy planning and dose delivery among Italian Centers in the 2004–2011 period. Dose-escalated treatments resulted in better biochemical control with a reduction in acute toxicity and higher but acceptable late toxicity, as not yet comprehensively associated with IMRT/IGRT. CTV-PTV margins &gt, 8 mm were associated with increased toxicity, again suggesting that IGRT—allowing for tighter margins—would reduce toxicity for dose escalated RT. These conclusions confirm the data obtained from randomized controlled studies.

Published
2021

49. High dose proton and photon-based radiation therapy for 213 liver lesions: a multi-institutional dosimetric comparison with a clinical perspective.

Author

Bonù ML, Nicosia L, Turkaj A, Pastorello E, Vitali P, Frassine F, Toraci C, Spiazzi L, Lechiara M, Frittoli B, Grazioli L, Ghirardelli P, Costantino G, Barbera F, Borghetti P, Triggiani L, Portolani N, Buglione M, Dionisi F, Giacomelli I, Lancia A, Magrini SM, and Tomasini D

Subjects
Humans, Protons, Radiotherapy Dosage, Radiotherapy Planning, Computer-Assisted methods, Radiosurgery methods, Radiotherapy, Intensity-Modulated methods, Proton Therapy, Radiation Injuries prevention & control, Liver Neoplasms radiotherapy
Abstract

Background: Stereotactic radiotherapy (SRT) and Proton therapy (PT) are both options in the management of liver lesions. Limited clinical-dosimetric comparison are available. Moreover, dose-constraint routinely used in liver PT and SRT considers only the liver spared, while optimization strategies to limit the liver damaged are poorly reported., Methods: Primary endpoint was to assess and compare liver sparing of four contemporary RT techniques. Secondary endpoints were freedom from local recurrence (FFLR), overall survival (OS), acute and late toxicity. We hypothesize that Focal Liver Reaction (FLR) is determined by a similar biologic dose. FLR was delineated on follow-up MRI. Mean C.I. was computed for all the schedules used. A so-called Fall-off Volume (FOV) was defined as the area of healthy liver (liver-PTV) receiving more than the isotoxic dose. Fall-off Volume Ratio (FOVR) was defined as ratio between FOV and PTV., Results: 213 lesions were identified. Mean best fitting isodose (isotoxic doses) for FLR were 18Gy, 21.5 Gy and 28.5 Gy for 3, 5 and 15 fractions. Among photons, an advantage in terms of healthy liver sparing was found for Vmat FFF with 5mm jaws (p = 0.013) and Cyberknife (p = 0.03). FOV and FOVR resulted lower for PT (p < 0.001). Three years FFLR resulted 83%. Classic Radiation induced liver disease (RILD, any grade) affected 2 patients., Conclusions: Cyberknife and V-MAT FFF with 5mm jaws spare more liver than V-MAT FF with 10 mm jaws. PT spare more liver compared to photons. FOV and FOVR allows a quantitative analysis of healthy tissue sparing performance showing also the quality of plan in terms of dose fall-off., (© 2024. The Author(s).)

Published
2024
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50. Adoption of Hybrid MRI-Linac Systems for the Treatment of Brain Tumors: A Systematic Review of the Current Literature Regarding Clinical and Technical Features.

Author

Guerini AE, Nici S, Magrini SM, Riga S, Toraci C, Pegurri L, Facheris G, Cozzaglio C, Farina D, Liserre R, Gasparotti R, Ravanelli M, Rondi P, Spiazzi L, and Buglione M

Subjects
Humans, Magnetic Resonance Imaging methods, Particle Accelerators, Magnetic Resonance Spectroscopy, Radiotherapy Dosage, Radiotherapy Planning, Computer-Assisted methods, Brain Neoplasms diagnostic imaging, Brain Neoplasms radiotherapy
Abstract

Background: Possible advantages of magnetic resonance (MR)-guided radiation therapy (MRgRT) for the treatment of brain tumors include improved definition of treatment volumes and organs at risk (OARs) that could allow margin reductions, resulting in limited dose to the OARs and/or dose escalation to target volumes. Recently, hybrid systems integrating a linear accelerator and an magnetic resonance imaging (MRI) scan (MRI-linacs, MRL) have been introduced, that could potentially lead to a fully MRI-based treatment workflow., Methods: We performed a systematic review of the published literature regarding the adoption of MRL for the treatment of primary or secondary brain tumors (last update November 3, 2022), retrieving a total of 2487 records; after a selection based on title and abstracts, the full text of 74 articles was analyzed, finally resulting in the 52 papers included in this review., Results and Discussion: Several solutions have been implemented to achieve a paradigm shift from CT-based radiotherapy to MRgRT, such as the management of geometric integrity and the definition of synthetic CT models that estimate electron density. Multiple sequences have been optimized to acquire images with adequate quality with on-board MR scanner in limited times. Various sophisticated algorithms have been developed to compensate the impact of magnetic field on dose distribution and calculate daily adaptive plans in a few minutes with satisfactory dosimetric parameters for the treatment of primary brain tumors and cerebral metastases. Dosimetric studies and preliminary clinical experiences demonstrated the feasibility of treating brain lesions with MRL., Conclusions: The adoption of an MRI-only workflow is feasible and could offer several advantages for the treatment of brain tumors, including superior image quality for lesions and OARs and the possibility to adapt the treatment plan on the basis of daily MRI. The growing body of clinical data will clarify the potential benefit in terms of toxicity and response to treatment.

Published
2023
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