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2. Cellulitis in the Emergency Department: A prospective cohort study with patient‐centred follow‐up.

Author

Nightingale, Rachael S, Etheridge, Nimai, Sweeny, Amy L, Smyth, Graham, Dace, William, Pellatt, Richard A.F., Snelling, Peter J, Yadav, Krishan, and Keijzers, Gerben

Subjects
ANTIBIOTICS, CELLULITIS treatment, CELLULITIS, SOFT tissue infections, ERYTHEMA, RESEARCH funding, EDEMA, SCIENTIFIC observation, QUESTIONNAIRES, HOSPITAL emergency services, TREATMENT effectiveness, DESCRIPTIVE statistics, LONGITUDINAL method, ORBITAL diseases, PAIN, ELECTRONIC health records, HEALTH outcome assessment, TREATMENT failure, COMPARATIVE studies
Abstract

Objective: There is substantial practice variation in the management of cellulitis with limited prospective studies describing the course of cellulitis after diagnosis. We aimed to describe the demographics, clinical features (erythema, warmth, swelling and pain), patient‐reported disease trajectory and medium‐term follow‐up for ED patients with cellulitis. Methods: Prospective observational cohort study of adults diagnosed with cellulitis in two EDs in Southeast Queensland, Australia. Patients with (peri)orbital cellulitis and abscess were excluded. Data were obtained from a baseline questionnaire, electronic medical records and follow‐up questionnaires at 3, 7 and 14 days. Clinician adjudication of day 14 cellulitis cure was compared to patient assessment. Descriptive analyses were conducted. Results: Three‐hundred patients (mean age 50 years, SD 19.9) with cellulitis were enrolled, predominantly affecting the lower limb (75%). Cellulitis features showed greatest improvement between enrolment and day 3. Clinical improvement continued gradually at days 7 and 14 with persistent skin erythema (41%) and swelling (37%) at day 14. Skin warmth was the feature most likely to be resolved at each time point. There was a discrepancy in clinician and patient assessment of cellulitis cure at day 14 (85.8% vs. 52.8% cured). Conclusions: A clinical response of cellulitis features can be expected at day 3 with ongoing slower improvement over time. Over one third of patients had erythema or swelling at day 14. Patients are less likely than clinicians to deem their cellulitis cured at day 14. Future research should include parallel patient and clinician evaluation of cellulitis to help develop clearer definitions of treatment failure and cure. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Nazi 'black' Propaganda to Britain: Secret Radio Stations and British Renegades.

Author

Smyth, Graham

Subjects
*RADIO stations, *WORLD War II, *BROADCASTING studios, *PROPAGANDA, *RADIO broadcasting, *NAZI Germany, 1933-1945
Abstract

While many will be familiar with the British traitor William Joyce who, as Lord Haw-Haw, became infamous for his radio broadcasts to Britain on behalf of Nazi Germany during the Second World War, much less widely known and studied is the work of Büro Concordia, an organisation created by Joseph Goebbels to broadcast 'black' propaganda from Berlin to Britain. Between 1940 and 1945 five secret radio stations posed as the voice of British dissident, anti-war organisations operating within the United Kingdom, broadcasting a stream of propaganda which aimed to demoralise the British people and undermine its support for the war. While they can be credited with some limited success, they fell far short of what Goebbels had hoped and expected from them. These stations were launched by the Reich Propaganda Ministry, but the two dozen writers and speakers who produced these broadcasts from studios in Berlin were British citizens. This study evaluates these 'British renegades' and the system that identified, recruited and trained them, and concludes that whatever potential there might have been to influence the course of the war, the employment of people so wholly unsuited to the work ensured that Concordia was bound to fail from its inception. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Radio Caledonia: Scottish Nationalism and Nazi Radio Propaganda, 1940–1942.

Author

Smyth, Graham

Subjects
*PROPAGANDA, *NATIONALISM, *RADIO stations, *RADIO broadcasting, *NAZIS, SCOTTISH history
Abstract

In June 1940, from somewhere in Scotland, a radio station named Radio Caledonia began to broadcast Scottish nationalist, anti-government and anti-war propaganda to Britain, on behalf of an organisation called the Scottish Peace Front. Its objective was to bring about Scotland's exit from the war, an end to the capitalist system, and the creation of an independent, socialist Scotland. The speaker and scriptwriter behind Radio Caledonia was Donald Grant, a Scot, since dubbed Scotland's Lord Haw-Haw. But Radio Caledonia was only superficially a Scottish nationalist station. In reality, the Scottish Peace Front was an entirely fictitious group, and Radio Caledonia's programmes were made in and broadcast from Berlin under the direction of Joseph Goebbels, as one element of his propaganda campaign against Britain. Radio Caledonia, like other similar 'secret stations' commissioned by Goebbels, was conceived of by the Nazi Propaganda Ministry, and its broadcasts written and produced by British renegades. This paper looks at Grant's background and political beliefs, the Nazi propaganda organisation within which he worked in Berlin, and the broadcast output of Radio Caledonia. It concludes that far from being an authentically nationalist or socialist enterprise, Radio Caledonia was devised by German Nazis and British fascists as a tool to achieve their shared aim of bringing about an end to Britain's involvement in the war. [ABSTRACT FROM AUTHOR]

Published
2024
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7. ‘Loathsome people’: British informers in the Nazi-occupied Channel Islands.

Author

Smyth, Graham

Abstract

For those who have speculated about the behaviour of the British people under Nazi rule, the Channel Islands have sometimes been used as a proxy, from which evidence can be selected to hypothesise about a Nazi-occupied Britain. In the area of collaboration, in particular, the historiography of the Channel Islands has been a victim of this flawed Anglo-centric approach. Looking at the evidence for the Channel Islands in their own right, this article looks at informing, as one of the most damaging and betterdocumented forms of collaboration, and asks: what kind of people were informers, what were their motives, and were they an integral part of a self-policing Nazi terror state? How did British Intelligence respond to informers on both professional and personal levels, and with what success did they investigate collaboration after the liberation of the Islands in May 1945? And how has the problematic evidence for informing, and by extension all collaboration, impacted perceptions of the Channel Islands under occupation? [ABSTRACT FROM AUTHOR]

Published
2023
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16. Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial

Author

Hill, Michael D, primary, Goyal, Mayank, additional, Menon, Bijoy K, additional, Nogueira, Raul G, additional, McTaggart, Ryan A, additional, Demchuk, Andrew M, additional, Poppe, Alexandre Y, additional, Buck, Brian H, additional, Field, Thalia S, additional, Dowlatshahi, Dar, additional, van Adel, Brian A, additional, Swartz, Richard H, additional, Shah, Ruchir A, additional, Sauvageau, Eric, additional, Zerna, Charlotte, additional, Ospel, Johanna M, additional, Joshi, Manish, additional, Almekhlafi, Mohammed A, additional, Ryckborst, Karla J, additional, Lowerison, Mark W, additional, Heard, Kathy, additional, Garman, David, additional, Haussen, Diogo, additional, Cutting, Shawna M, additional, Coutts, Shelagh B, additional, Roy, Daniel, additional, Rempel, Jeremy L, additional, Rohr, Axel CR, additional, Iancu, Daniela, additional, Sahlas, Demetrios J, additional, Yu, Amy Y X, additional, Devlin, Thomas G, additional, Hanel, Ricardo A, additional, Puetz, Volker, additional, Silver, Frank L, additional, Campbell, Bruce C V, additional, Chapot, René, additional, Teitelbaum, Jeanne, additional, Mandzia, Jennifer L, additional, Kleinig, Timothy J, additional, Turkel-Parrella, David, additional, Heck, Donald, additional, Kelly, Michael E, additional, Bharatha, Aditya, additional, Bang, Oh Young, additional, Jadhav, Ashutosh, additional, Gupta, Rishi, additional, Frei, Donald F, additional, Tarpley, Jason W, additional, McDougall, Cameron G, additional, Holmin, Staffan, additional, Rha, Joung-Ho, additional, Puri, Ajit S, additional, Camden, Marie-Christine, additional, Thomalla, Götz, additional, Choe, Hana, additional, Phillips, Stephen J, additional, Schindler, Joseph L, additional, Thornton, John, additional, Nagel, Simon, additional, Heo, Ji Hoe, additional, Sohn, Sung-Il, additional, Psychogios, Marios-Nikos, additional, Budzik, Ronald F, additional, Starkman, Sidney, additional, Martin, Coleman O, additional, Burns, Paul A, additional, Murphy, Seán, additional, Lopez, George A, additional, English, Joey, additional, Tymianski, Michael, additional, Demchuk, Andrew, additional, Barber, Philip, additional, Smith, Eric, additional, Bal, Simerpreet, additional, Subramaniam, Suresh, additional, Peters, Steven, additional, Couillard, Phillippe, additional, Klein, Gary, additional, Stys, Peter, additional, Menon, Bijoy, additional, Coutts, Shelagh, additional, Almekhlafi, Mohammed, additional, Hill, Michael, additional, Wong, John, additional, Mitha, Alim, additional, Eesa, Muneer, additional, Morrish, William, additional, Alqatani, Saad, additional, Kashani, Nima, additional, Ospel, Johanna, additional, Venkatesan, Prasanna, additional, Teleg, Erika, additional, Sitaram, Amith, additional, Graham, Brett, additional, Van Gaal, Stephen, additional, Moussaddy, Aimen, additional, Chakraborty, Debabrata, additional, Maraj, Nicholas, additional, Loockey, Andrew, additional, Chen, Shuo, additional, Singh, Ravinder, additional, Alsultan, Abdulaziz, additional, Asuncion, Ria, additional, Tse, Dominic, additional, Doshi, Darshan, additional, Volny, Ondrej, additional, Ojha, Piyush, additional, Wadhwa, Ankur, additional, Marko, Martha, additional, Singh, Nishita, additional, Wasyliw, Sanchea, additional, Ryckborst, Karla, additional, Kenney, Carol, additional, Save, Supriya, additional, Jambula, Anitha, additional, Newcommon, Nancy, additional, Hull, Gavin, additional, Blackstock, Darcy, additional, Kiszczak, Sharon, additional, Zimmel, Leslie, additional, Wright, Michelle, additional, Jahraus, Cari, additional, Andersen, Linda, additional, Bohn, Shelly, additional, Paul, Joseph, additional, Zhang, Oiao, additional, Doram, Craig, additional, Lowerison, Mark, additional, Hanley, Andrea, additional, Campbell, Lori, additional, Ure, Ashley, additional, Taylor, Francis, additional, Hul, Dominic, additional, Wiebe, Samuel, additional, Saluzzi, Marina, additional, Blenkin, Nicole, additional, Frayne, Richard, additional, Buck, Brian, additional, Butcher, Kenneth, additional, Shuaib, Ashfaq, additional, Jeerakathil, Tom, additional, Jickling, Glen, additional, Emery, Derek, additional, Rempel, Jeremy, additional, Owen, Richard, additional, Ashforth, Robert, additional, Yeo, Tom, additional, Kotylak, Trevor, additional, O'Kelly, Cian, additional, Chow, Michael, additional, Siddiqui, Muzaffer, additional, Saqqur, Maher, additional, D'Souza, Atlantic, additional, Lloret, Mar, additional, Butt, Asif, additional, Nomani, Ali, additional, Kalashyan, Hayrapet, additional, Thirunavukkarasu, Sibi, additional, Jabs, Juline, additional, Fairall, Paige, additional, Piquette, Lori, additional, Phillips, Stephen, additional, Green, A. Laine, additional, Gubitz, Gordon, additional, Heidenreich, Jens, additional, Huynh, Thien, additional, Shankar, Jai, additional, Maloney, William, additional, Vandorpe, Robert, additional, Schmidt, Matthias, additional, Pickett, Gwynedd, additional, Weeks, Adrienne, additional, Jarrett, Judith, additional, MacDonald, Debbie, additional, Arsenault, Joanna, additional, Kinnear, Ruth, additional, Mandzia, Jennifer, additional, Mayich, Michael, additional, Boulton, Melfort, additional, Bullrich, Maria, additional, Fridman, Sebastian, additional, Kiwan, Ruba, additional, Lee, Donald, additional, Lownie, Stephen, additional, Khaw, Alexander, additional, Pandey, Sachin, additional, Sharma, Manas, additional, Sposato, Luciano, additional, Wade, Kevin, additional, Beauchamp, Beth, additional, Lambourn, Lindsay, additional, Amato-Marziali, Belinda, additional, Poppe, Alexandre, additional, Daneault, Nicole, additional, Deschaintre, Yan, additional, Gioia, Laura, additional, Jacquin, Grégory, additional, Odier, Céline, additional, Stapf, Christian, additional, Raymond, Jean, additional, Weill, Alain, additional, Lapierre, Marlène, additional, Jadil, Nadia, additional, Jolteus, Judlène, additional, Angle, Mark, additional, Hannouche, Mathew, additional, Badawy, Mohamed, additional, Letourneau, Justin, additional, Cortes, Maria, additional, Linnell, Grant, additional, Tampieri, Donateela, additional, Vieira, Lucy, additional, Legault, Catherine, additional, Durcan, Liam, additional, Moore, Angela, additional, Cole, Erin, additional, Magnussen, Claire, additional, Salmon, Kristiana, additional, Khalil, Salma, additional, Desloges, Isabelle, additional, Waxman, Lindsay, additional, Abdon, Wynne, additional, Lai, Sonia, additional, Shamy, Michel, additional, Stotts, Grant, additional, Blacquiere, Dylan, additional, Lesiuk, Howard, additional, Quateen, Aiman, additional, Drake, Brian, additional, Dewar, Brian, additional, Daham, Zeinab, additional, Kelly, Michael, additional, Hunter, Gary, additional, Peeling, Lissa, additional, Whelan, Ruth, additional, Garner, Aaron, additional, Urroz, Lilian, additional, Maley, Sharleen, additional, Silver, Frank, additional, Casaubon, Leanne, additional, Pikula, Aleksandra, additional, Del Campo, Martin, additional, Schaafsma, Joanna, additional, Jaigobin, Cheryl, additional, Krings, Timo, additional, Pereira, Vitor, additional, Agid, Ronit, additional, Farb, Richard, additional, Kalman, Libby, additional, Cayley, Anne, additional, Williams, Janice, additional, Stewart, Tim, additional, Misquitta, Karen, additional, Selchen, Daniel, additional, Marotta, Thomas, additional, Sarma, Dipanka, additional, Montanera, Walter, additional, Spears, Juluan, additional, Saposnik, Gustavo, additional, Kostyrko, Pawel, additional, Li, Yangmei, additional, Parra-Farina, Carmen, additional, Bengzon Diestro, Jose Danilo, additional, Verreault, Steve, additional, Mackey, Ariane, additional, Audet, Marie-Eve, additional, Milot, Geneviève, additional, Lavoie, Pascale, additional, Gariépy, Jean-Luc, additional, Collard, Karine, additional, Haché, Annette, additional, Van Adel, Brian, additional, Sahlas, Demetrios, additional, Alshanbari, Ahmed, additional, Baldwin, Josephine, additional, Catanese, Luciana, additional, Chen, Bing, additional, De Sa Boasquevisque, Danielle, additional, Deshmukh, Aviraj, additional, Knapman, Jordan, additional, Lamers, Shana, additional, Larrazabal, Ramiro, additional, MacMillan, Susan, additional, Mai, Lauren, additional, Mattia, Alicia, additional, Nayar, Sumiti, additional, Ng, Kuan, additional, Oczkowski, Wieslaw, additional, Perera, Kanjana, additional, Shawawrah, Mays, additional, Shoamanesh, Ashkan, additional, Sobhi, Gita, additional, Syed, Nabeel, additional, Taher, Noran, additional, Vandervelde, Cheyanne, additional, Wang Pharm, Di, additional, Field, Thalia, additional, Teal, Philip, additional, Benavente, Oscar, additional, Wilson, Laura, additional, Mann, Sharanpal, additional, Yip, Samuel, additional, Murphy, Colleen, additional, Heran, Manraj, additional, Rohr, Axel, additional, Settecase, Fabio, additional, Redekop, Gary, additional, Haw, Charles, additional, Maclean, Genoveva, additional, Murray, Karina, additional, Chiu, Rosalin, additional, Flexman, Alana, additional, Strecha, Eilidh, additional, Gayton, Yolanda, additional, Yip, Judy, additional, Swartz, Richard, additional, Boulos, Mark, additional, Gladstone, David, additional, Yu, Amy, additional, Hopyan, Julia, additional, Khosravani, Houman, additional, Manosalva Alzate, Herbert, additional, Southwell, Alisia, additional, Kamra, Maneesha, additional, Lopes, Kaitlyn, additional, Kapoor, Arunima, additional, da Costa, Leodante, additional, Yang, Victor, additional, Dyer, Erin, additional, Shah, Ruchir, additional, Knowles, Brenda, additional, Nichols, Jennifer, additional, Patterson, Jennifer, additional, Cope, Krista, additional, Dickerson, Lee, additional, Barton, Katrina, additional, Gray, Kimberly, additional, Massengale, Ticey, additional, Miller, Melanie, additional, Simpson, Cindy, additional, Walker, Sabrina, additional, Tennyson-Yemm, Chlin, additional, Devlin, Thomas, additional, Frei, Donald, additional, Bellon, Richard, additional, Atchie, Benjamin, additional, Kaminsky, Ian, additional, Wilson, Duandelyn, additional, Schraeder, Nicolle, additional, Arias, Eric, additional, Kodis, Lisa, additional, Talley, Mark, additional, Edinger, Alex, additional, Talley, Tiffany, additional, Dempsey, Ita, additional, Williams, Laurie, additional, Williams, Scott, additional, Kupniewski, Sonny, additional, Fasbinder, Brad, additional, Snead, Joanna, additional, Mackenzie, Larami, additional, Weisman, Davi, additional, Kozak, Osman, additional, Shah, Qaisar, additional, Gzesh, Dan, additional, Kulandaivel, Kandan, additional, Khoury, John, additional, Klein, Brad, additional, Bussinger, Patricia, additional, Griffin, Lisa, additional, dePalmo, Ashley, additional, Oliva, Cynthia, additional, Jovin, Tudor, additional, Kenmuir, Cynthia, additional, Jankowitz, Brian, additional, Gross, Bradley, additional, Rocha, Marcelo, additional, Starr, Matthew, additional, Brown, Merritt, additional, Hawkes, Christine, additional, Shah, Kavit, additional, Tememe, Danoushka, additional, Walker, Gregory, additional, Patel, Pratit, additional, Klein, Bradley, additional, Ziayee, Habibullah, additional, Limaye, Kaustubh, additional, Baxendell, Lisa, additional, Gilchrist, Vicki, additional, Feineigle, Patricia, additional, Toseki Haibach, Kelsea, additional, Van Every, Cathy, additional, Desai, Shashyat, additional, Zulfiqar, Maryam, additional, Gibson, Linda, additional, Barrett, Sean, additional, Arcot, Karthikeyan, additional, DiCrescento, Steven, additional, Farkas, Jeffrey, additional, Filipowski, Gregory, additional, Frontera, Jennifer, additional, Joset, Danielle, additional, Liff, Jeremy, additional, Scher, Erica, additional, McDougall, Cameron, additional, Kelly, Cheryl, additional, Patel, Akshal, additional, Monteith, Stephen, additional, Atchaneeyasakul, Kunakorn, additional, Burgos, Adrian, additional, Chua, Janice Anne, additional, Gaines, Nathan, additional, Grunberg, Ileana, additional, Guzy, Judy, additional, Liu, Zuolu, additional, Maluste, Neil, additional, Ramirez, Lucas, additional, Sharma, Latisha, additional, Brown, Morry, additional, McDonald, Colin, additional, Calderon, Mateo, additional, Hargis, Mitch, additional, Roels, Christina, additional, Emmady, Prabhu, additional, Alvi, Talat, additional, McTaggart, Ryan, additional, Jayaraman, Mahesh, additional, Cutting, Shawna, additional, Smith, Wendy, additional, Foley, Susan, additional, Paolucci, Gino, additional, Has, Richard, additional, Quinn, Katie, additional, Fuller, Lindsey, additional, Brierley, Rebecca, additional, Watkins, Christina, additional, Demir, Nicole, additional, Lopez, George, additional, Vargas, Alejandro, additional, Osteraas, Nicholas, additional, Holtz, Becky, additional, Hanel, Ricardo, additional, Aghaebrahim, Amin, additional, Chmayssani, Mohamad, additional, Naval, Neeraj, additional, Day, Jason, additional, Dellorso, Scott, additional, Ludwig, Benjamin, additional, Schemmel, Derek, additional, Ebreo, Nancy, additional, Bell, Karen, additional, Lewis, Lanai, additional, Delucia, Marjorie, additional, Nogueira, Raul, additional, Frankel, Michael, additional, Bhatt, Nirav, additional, Bianchi, Nicolas, additional, Anderson, Aaron, additional, Belagaje, Samir, additional, Liberato, Bernardo, additional, Rangaraju, Srikant, additional, Al-Bayati, Alhamza, additional, Grossberg, Jonathan, additional, Craft, Leah, additional, Schindler, Kiva, additional, Schaad, Erin, additional, Schultz, Meagan, additional, Southerly, Lorretta, additional, Doppelheuer, Shannon, additional, Charlton, Jacquelyn, additional, Faggard, Jason, additional, Barbret, Zuzana, additional, DukSoo Han, Ethan, additional, Walters, Robin, additional, Dolia, Jaydevsinh, additional, El-Jamal, Sleiman, additional, Eby, Brendan, additional, Saleem, Yasir, additional, Pearl, Harrison, additional, Patel, Kishan, additional, Rahman, Haseeb, additional, Butt, Reema, additional, English, Stephen, additional, Puri, Ajit, additional, Howk, Mary, additional, Singh, Jasmeet, additional, Massari, Francesco, additional, DeMacedo Rodrigues, Katyucia, additional, Kuhn, Anna, additional, Barazangi, Nobl, additional, Telischak, Nick, additional, Kim, Warren, additional, Ross, Josh, additional, DeVole, Nata, additional, Redford, Jessica, additional, Ferreira, Milena, additional, Ponting, Katie, additional, Shen, Helen, additional, Bedenk, Ann, additional, Patel, Susila, additional, Fernandess, Julia, additional, Ke, Michael, additional, Spokoyny, Ilanit, additional, Gao, Billy, additional, Tong, David, additional, Chen, Charlene, additional, Wong, Christine, additional, Choe, Jessica, additional, Martin, Coleman, additional, Summers, Debbie, additional, Boutwell, Christine, additional, Olds, Karin, additional, Crandall, Suzanne, additional, Eatman, John, additional, Akhtar, Naveed, additional, Holloway, William, additional, Halpin, Jared, additional, Donegan, Brett, additional, Schindler, Joseph, additional, Hwang, David, additional, Gilmore, Emily, additional, Petersen, Nils, additional, Sheth, Kevin, additional, Brown, Stacy, additional, Beekman, Rachel, additional, George, Benjamin, additional, Kaddouh, Firas, additional, Falcone, Guido, additional, Wira, Charles, additional, Matouk, Charles, additional, Loomis, Caitlin, additional, Amin, Hardik, additional, Stretz, Hans Christoph, additional, Narula, Reshma, additional, Jasne, Adam, additional, Sansing, Lauren, additional, Agarwal, Tijil, additional, Jasak, Sara, additional, Fontaine, Briana, additional, King, Zachary, additional, Kuohn, Lindsey, additional, Orgass, Hailey, additional, Leary, Megan, additional, Nye, Joan, additional, Halbert, Kelsey, additional, Nystrom, Karin, additional, Neuschatz, Kaile, additional, Petrucci, Dawn, additional, Coppola, Anna, additional, Tarpley, Jason, additional, Joyce, Treasure, additional, Hou, Sam, additional, Umekubo, Mark, additional, Nakamura, Catrice, additional, Ovando, Renee, additional, Zuniga, Diana, additional, Nien, Yih Lin, additional, Basto, Fernando Mayor, additional, Arch, Allison, additional, Jong, Laura, additional, Conrad, William, additional, Abbott, Tara, additional, Yao, Jay, additional, Caganap, Scott, additional, Jordan, John, additional, Teitelbaum, George, additional, Darflinger, Robert, additional, Bain, Marianne, additional, Budzik, Ronald, additional, Czerniak, Jennifer, additional, Groezinger, Katherine, additional, Hicks II, William, additional, Kaskar, Omran, additional, Katz, Brian, additional, Loochtan, Aaron, additional, Pema, Peter, additional, Rai, Vivek, additional, Vora, Nirav, additional, Brown, Amanda, additional, Goodman, Diane, additional, Danenbergs, Barb, additional, Gossett, Monica, additional, Chung, Jong-Won, additional, Jeon, Pyoung, additional, Kim, Keon Ha, additional, Lim, Yun Jeong, additional, Nam, Hyo Suk, additional, Kim, Young Dae, additional, Park, HyungJong, additional, Hwang, In Gun, additional, Ha, Wooseok, additional, Choi, Jin Kyo, additional, Jeong, Kyungsun, additional, Park, Hee-Kwon, additional, Yoon, Cindy, additional, Kim, Bo-Kyung, additional, Kim, Chang-hyun, additional, Yoo, Joonsang, additional, Hong, Jeong-Ho, additional, Park, Hyungjong, additional, Kim, Sohyeon, additional, Choi, Moonkyung, additional, Bae, Hyoeun, additional, Lee, Jun Seok, additional, Lee, Jae-Joon, additional, Jun, Go-Eun, additional, Jeon, Sujeong, additional, Campbell, Bruce, additional, Mitchell, Peter, additional, Yassi, Nawaf, additional, Davis, Stephen, additional, Donnan, Geoffrey, additional, Parsons, Mark, additional, Yan, Bernard, additional, Dowling, Richard, additional, Bush, Steven, additional, Wu, Teddy, additional, Shah, Darshan, additional, Zhao, Henry, additional, Salvaris, Patrick, additional, Alemseged, Fana, additional, Ng, Felix, additional, Williams, Cameron, additional, Balabanski, Anna, additional, Dos Santos, Angela, additional, Ng, Jo-Lyn, additional, McDonald, Amy, additional, Jackson, David, additional, Tsoleridis, Jessica, additional, Pesavento, Lauren, additional, Kleinig, Timothy John, additional, Nurs, Roy Drew, additional, Cranefield, Jennifer, additional, Scroop, Rebecca, additional, Cagi, Lavenia, additional, Harvey, Jackson, additional, Waters, Michael, additional, Brennan, Robert, additional, O'Hare, Alan, additional, Power, Sarah, additional, Williams, David, additional, Boyle, Karl, additional, Moynihan, Barry, additional, Liddy, Ann-Marie, additional, Large, Margaret, additional, Cullen, Ailbhe, additional, Walsh, Roisin, additional, Martin, Emma, additional, Lynch, Julie, additional, McElroy, Sinéad, additional, Coveney, Sarah, additional, Deegan, Caroline, additional, Horgan, Gillian, additional, Kelly, Peter, additional, Laffan, Aoife, additional, Llamas-Osorio, Yudy, additional, Lynch, Catherine, additional, Mac Mahon, Peter, additional, Marnane, Michael, additional, McCabe, John, additional, Burns, Paul, additional, Tauro, Suzanne, additional, Cuddy, Sarah, additional, Rennie, Ian, additional, Smyth, Graham, additional, Flynn, Peter, additional, Wiggam, Ivan, additional, Kerr, Enda, additional, Gordon, Patricia, additional, Fearon, Patricia, additional, Roberts, Geralt, additional, Patterson, Cathy, additional, Adams, Karen, additional, Wells, Brian, additional, McFarland, Margaret, additional, Moreira, Tiago, additional, Sjöstrand, Christina, additional, Mazya, Michael, additional, Almqvist, Håkan, additional, Wahlgren, Nils, additional, Steinberg, Anna, additional, Cooray, Charith, additional, Eriksson, Einar, additional, Thorén, Magnus, additional, Keselman, Boris, additional, Ahmed, NIaz, additional, Holmberg, Åke, additional, Axelsson, Maria, additional, Berglund, Annika, additional, Golsari, Amir, additional, Hoppe, Julia, additional, Deb-Chatterji, Milani, additional, Cheng, Bastian, additional, Barrow, Ewgenia, additional, Schlemm, Eckhard, additional, Lettow, Iris, additional, Jensen, Märit, additional, Otto, Dagmar, additional, Jaramillo, Kirsten, additional, Appelbohm, Hannes, additional, Fiehler, Jens, additional, Bester, Maxim, additional, Schönfeld, Michael, additional, Brekenfeld, Caspar, additional, Holst, Brigitte, additional, Wortmann, Ginette, additional, Koch, Friederike, additional, Gerber, Johannes, additional, Abramyuk, Andrij, additional, Kaiser, Daniel, additional, Winzer, Simon, additional, Prakapenia, Alexandra, additional, Pallesen, Lars-Peder, additional, Siepmann, Timo, additional, Barlinn, Kristian, additional, Haase, Kathrin, additional, Sauer, Angela, additional, Liman, Jan, additional, Brehm, Alex, additional, Maus, Volker, additional, Hollstein, Nicole, additional, Reinke, Annika, additional, Neitz, Gustav, additional, Schnieder, Marlena, additional, Schwarz, Margret, additional, Ibrahim, Allam, additional, Müller, Julia, additional, Meister, Stefanie, additional, Bäumle, Berit, additional, Pilgram-Pastor, Sara, additional, Wallocha, Marta, additional, Stauder, Michael, additional, Celik, Ekin, additional, Stracke, Paul, additional, Müller, Nicole, additional, Weber, Ralph, additional, Velktamp, Roland, additional, Ringleb, Peter Arthur, additional, Heyse, Miriam, additional, Amiri, Hemasse, additional, Mundiyanapurath, Sibu, additional, Chen, Min, additional, Bevrle, Elisabeth, additional, Beck, Perdita, additional, Möhlenbruch, Markus alfred, additional, Potvin, Alphonse, additional, Harris, Cameron, additional, Wang, Chong, additional, Adams, Corey, additional, Mayor, Diana, additional, Garman, Dave, additional, Chau, Davis, additional, Wu, Jane, additional, Lunn, Janet, additional, Bermanis, Liat, additional, Teyes, Lucy, additional, Constant, Marc, additional, Galsim, Maria, additional, Helbin, Michael, additional, Leroux, Michelle, additional, Felix, Nicole, additional, Bendre, Nilima, additional, Cuthbert, Sandra, additional, Brokx, Steve, additional, Zhang, Yichuan, additional, Lingham, Trudy, additional, Kohli, Yatika, additional, Salter, Michael, additional, Liebeschuetz, Joseph, additional, Hofmann, Frieder, additional, Constant, John, additional, Soeder, Tom, additional, Snoke, Kara, additional, Bologa, Monica, additional, Stahl, Kimberly, additional, and Graziewicz, Maria, additional

Published
2020
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20. Autologous Lipo-Dermal Advancement Flap for Inframammary Fold Reconstruction: A Technical Note for Prevention and Management of Caudal Breast Implant Migration

Author

Elfieshawy, Hatem, Smyth, Graham, and Jasinska, Monika

Abstract

Inferior breast implant displacement, also known as caudal migration, or bottoming-out, is a known complication of breast augmentation. This leads to a loss of upper pole fullness, a more superiorly located nipple-areolar complex, and an unnatural appearance. Avoiding these complaints has been a longstanding challenge in the field of aesthetics and this technical note suggests a novel solution. This technical note describes the process of preoperative assessment, careful markings, and the use of an autologous lipo-dermal advancement flap that has been designed, mobilized, and rotated to be internally fixated to costal margins and the relevant deep fascial structures at the proposed inframammary fold level. This technique creates a robust partitioning hammock-like structure that stabilizes the breast implant and prevents future caudal displacement. The described technique may be implemented as an independent solution, or as an adjunct to other modalities like biological meshes in revision breast surgery.

Published
2024
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23. ESCAPE to Reality, Post-Trial Outcomes in an ESCAPE Centre: A Retrospective Case-Control Study.

Author

Nixon, Amy M., Jamison, Michael, Rennie, Ian M., Flynn, Peter A., Smyth, Graham, Wiggam, Ivan, Kerr, Enda, Fulton, Ailsa, Hunter, Annemarie, and Burns, Paul A.

Abstract

Introduction The Royal Victoria Hospital, Belfast provides the regional neuroendovascular service for Northern Ireland and was an enrolling centre for the ESCAPE endovascular stroke trial. Our aim was to assess outcomes for patients presenting with acute stroke following discontinuation of trial enrolment at our centre. Methods We collected data on all patients presenting with acute stoke between Nov-1st-2014 and Oct-31st-2015 who received endovascular treatment or received IV thrombolysis (IV-tPA) alone. ESCAPE eligibility of each patient was assessed. Primary outcome was modified Rankin Score (mRS) at 3 months. Results 129 patients presented with acute stoke symptoms during the time period; 56/129 (43.4%) patients in the intervention group and 73/129 (56.5%) patients in the control group. In the interventional group, 42/56 (75%) were considered ESCAPE eligible and 14/56 (25%) were considered ESCAPE ineligible. 30/42 (71.4%) ESCAPE eligible patients had a positive functional outcome at 3 months compared to 9/14 (64.2%) ESCAPE ineligible patients. In the control group, 37 (50.7%) had identifiable thrombotic occlusion and 13/37 (35.1%) were considered eligible for intervention. 4/13 (30.8%) achieved functional independence (mRS<3) at 3 months. There was a statistically significant difference in functional independence in those who underwent endovascular therapy compared to the control group (p= 0.04). Conclusion ESCAPE eligible patients in our centre had favourable outcome rates superior to the published trial data. ESCAPE ineligible patients tended to do slightly less well, but still better than the favourable outcome rates achieved with IVtPA alone. There is potentially a wide discordance between the threshold for futility and trial eligibility criteria when considering endovascular treatment for acute ischaemic stroke. [ABSTRACT FROM AUTHOR]

Published
2018

30. Adipose tissue mitochondrial dysfunction triggers a lipodystrophic syndrome with insulin resistance, hepatosteatosis, and cardiovascular complications.

Author

Vernochet, Cecile, Damilano, Federico, Mourier, Arnaud, Bezy, Olivier, Mori, Marcelo A., Smyth, Graham, Rosenzweig, Anthony, Larsson, Nils-Göran, and Kahn, C. Ronald

Subjects
ADIPOSE tissues, OBESITY, TYPE 2 diabetes, HYPERTENSION, CARDIAC hypertrophy
Abstract

Mitochondrial dysfunction in adipose tissue occurs in obesity, type 2 diabetes, and some forms of lipodystrophy, but whether this dysfunction contributes to or is the result of these disorders is unknown. To investigate the physiological consequences of severe mitochondrial impairment in adipose tissue, we generated mice deficient in mitochondrial transcription factor A (TFAM) in adipocytes by using mice carrying adiponectin-Cre and TFAM floxed alleles. These adiponectin TFAM-knockout (adipo-TFAM-KO) mice had a 75-81% reduction in TFAM in the subcutaneous and intra-abdominal white adipose tissue (WAT) and interscapular brown adipose tissue (BAT), causing decreased expression and enzymatic activity of proteins in complexes I, III, and IV of the electron transport chain (ETC). This mitochondrial dysfunction led to adipocyte death and inflammation in WAT and a whitening of BAT. As a result, adipo-TFAM-KO mice were resistant to weight gain, but exhibited insulin resistance on both normal chow and high-fat diets. These lipodystrophic mice also developed hypertension, cardiac hypertrophy, and cardiac dysfunction. Thus, isolated mitochondrial dysfunction in adipose tissue can lead a syndrome of lipodystrophy with metabolic syndrome and cardiovascular complications. [ABSTRACT FROM AUTHOR]

Published
2014
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31. Advances in Thermal Image Analysis for the Detection of Pregnancy in Horses Using Infrared Thermography.

Author

Domino, Małgorzata, Borowska, Marta, Kozłowska, Natalia, Zdrojkowski, Łukasz, Jasiński, Tomasz, Smyth, Graham, and Maśko, Małgorzata

Subjects
THERMOGRAPHY, MARES, IMAGE analysis, RGB color model, THERMAL analysis, PREGNANCY, HORSES
Abstract

Infrared thermography (IRT) was applied as a potentially useful tool in the detection of pregnancy in equids, especially native or wildlife. IRT measures heat emission from the body surface, which increases with the progression of pregnancy as blood flow and metabolic activity in the uterine and fetal tissues increase. Conventional IRT imaging is promising; however, with specific limitations considered, this study aimed to develop novel digital processing methods for thermal images of pregnant mares to detect pregnancy earlier with higher accuracy. In the current study, 40 mares were divided into non-pregnant and pregnant groups and imaged using IRT. Thermal images were transformed into four color models (RGB, YUV, YIQ, HSB) and 10 color components were separated. From each color component, features of image texture were obtained using Histogram Statistics and Grey-Level Run-Length Matrix algorithms. The most informative color/feature combinations were selected for further investigation, and the accuracy of pregnancy detection was calculated. The image texture features in the RGB and YIQ color models reflecting increased heterogeneity of image texture seem to be applicable as potential indicators of pregnancy. Their application in IRT-based pregnancy detection in mares allows for earlier recognition of pregnant mares with higher accuracy than the conventional IRT imaging technique. [ABSTRACT FROM AUTHOR]

Published
2022
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32. Direct puncture of the V3 segment of the vertebral artery in acute basilar artery stroke: an alternative approach in desperate circumstances.

Author

O'Reilly ST, Rennie I, McIlmoyle J, and Smyth G

Subjects
Adult, Arterial Occlusive Diseases complications, Endovascular Procedures methods, Humans, Male, Punctures, Stents, Stroke etiology, Thrombosis complications, Treatment Outcome, Arterial Occlusive Diseases surgery, Basilar Artery surgery, Stroke surgery, Thrombosis surgery, Vertebral Artery surgery
Abstract

A patient in his mid-40s presented with acute basilar artery thrombosis 7 hours postsymptom onset. Initial attempts to perform mechanical thrombectomy (MT) via the femoral and radial arterial approaches were unsuccessful as the left vertebral artery (VA) was occluded at its origin and the right VA terminated in the posterior inferior cerebellar artery territory, without contribution to the basilar system. MT was thus performed following ultrasound-guided direct arterial puncture of the left VA in its V3 segment, with antegrade advancement of a 4 French radial access sheath. First pass thrombolyisis in cerebral infarction (TICI) 3 recanalisation achieved with a 6 mm Solitaire stent retriever and concurrent aspiration on the 4 French sheath. Vertebral closure achieved with manual compression., Competing Interests: Competing interests: None declared., (© BMJ Publishing Group Limited 2019. No commercial re-use. See rights and permissions. Published by BMJ.)

Published
2019
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33. Differential Role of Insulin/IGF-1 Receptor Signaling in Muscle Growth and Glucose Homeostasis.

Author

O'Neill BT, Lauritzen HP, Hirshman MF, Smyth G, Goodyear LJ, and Kahn CR

Subjects
Animals, Female, Homeostasis, Male, Mice, Mice, Knockout, Phosphorylation, Signal Transduction, Glucose metabolism, Muscle Proteins metabolism, Muscle, Skeletal growth & development, Muscle, Skeletal metabolism, Receptor, IGF Type 1 metabolism, Receptor, Insulin metabolism
Abstract

Insulin and insulin-like growth factor 1 (IGF-1) are major regulators of muscle protein and glucose homeostasis. To determine how these pathways interact, we generated mice with muscle-specific knockout of IGF-1 receptor (IGF1R) and insulin receptor (IR). These MIGIRKO mice showed >60% decrease in muscle mass. Despite a complete lack of insulin/IGF-1 signaling in muscle, MIGIRKO mice displayed normal glucose and insulin tolerance. Indeed, MIGIRKO mice showed fasting hypoglycemia and increased basal glucose uptake. This was secondary to decreased TBC1D1 resulting in increased Glut4 and Glut1 membrane localization. Interestingly, overexpression of a dominant-negative IGF1R in muscle induced glucose intolerance in MIGIRKO animals. Thus, loss of insulin/IGF-1 signaling impairs muscle growth, but not whole-body glucose tolerance due to increased membrane localization of glucose transporters. Nonetheless, presence of a dominant-negative receptor, even in the absence of functional IR/IGF1R, induces glucose intolerance, indicating that interactions between these receptors and other proteins in muscle can impair glucose homeostasis., (Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.)

Published
2015
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