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8. Complex phase-fluctuation effects correlated with granularity in superconducting NbN nanofilms

Author

Sharma, Meenakshi, Singh, Manju, Rakshit, Rajib K., Singh, Surinder P., Fretto, Matteo, De Leo, Natascia, Perali, Andrea, and Pinto, Nicola

Subjects
Condensed Matter - Superconductivity, Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

Superconducting nanofilms are tunable systems that can host a 3D-2D dimensional crossover, leading to the Berezinskii-Kosterlitz-Thouless (BKT) superconducting transition approaching the 2D regime. Reducing further the dimensionality, from 2D to quasi-1D, superconducting nanostructures with disorder can generate quantum and thermal phase slips (PS) of the order parameter. Both BKT and PS are complex phase fluctuation phenomena of difficult experimental detection. Here, we have characterized superconducting NbN nanofilms thinner than 15 nm, on different substrates, by temperature dependent resistivity and current-voltage (I-V) characteristics. Our measurements have evidenced clear features related to the emergence of BKT transition and PS events. The contemporary observation in the same system of BKT transition and PS events and their tunable evolution in temperature and thickness, has been explained as due to the nano-conducting paths forming in a granular NbN system. In one of the investigated samples we have been able to trace and characterize the continuous evolution in temperature from quantum to thermal PS. Our analysis has established that the detected complex phase phenomena are strongly related to the interplay between the typical size of the nano-conductive paths and the superconducting coherence length., Comment: 22 pages, 14 figures

Published
2022

9. Introduction to Biomaterial-Inspired Nanomedicines

Author

Yadav, Krishna, Ajazuddin, Alexander, Amit, Pandey, Priyanka, Raza, Wasim, Singh, Manju Rawat, Singh, Deependra, Tirkey, Rakesh, Jangde, Rajendra, Sahu, Pravin Kumar, Bagchi, Anindya, Chauhan, Nagendra Singh, Pradhan, Madhulika, Pradhan, Madhulika, editor, Yadav, Krishna, editor, and Singh Chauhan, Nagendra, editor

Published
2024
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21. Adhatoda vasica and Tinospora cordifolia extracts ameliorate clinical and molecular markers in mild COVID-19 patients: a randomized open-label three-armed study

Author

Verma, Mukta, Rawat, Neha, Rani, Ritu, Singh, Manju, Choudhary, Aditi, Abbasi, Sarfaraz, Kumar, Manish, Kumar, Sachin, Tanwar, Ankur, Misir, Bishnu Raman, Khanna, Sangeeta, Agrawal, Anurag, Faruq, Mohammed, Rai, Shalini, Tripathi, Richa, Kumar, Anil, Pujani, Mukta, Bhojani, Meera, Pandey, Anil Kumar, Nesari, Tanuja, and Prasher, Bhavana

Published
2023
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32. Robotic Interactive Companion: Human–Robot Interaction for Wellness

Author

Jacob, Alan, Singh, Manju, Husain, Agha Asim, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Saini, H. S., editor, Singh, R. K., editor, Tariq Beg, Mirza, editor, Mulaveesala, Ravibabu, editor, and Mahmood, Md Rashid, editor

Published
2022
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39. Contributors

Author

Aarti, Chirom, primary, Agana, Theresa Appiah, additional, Agyare, Christian, additional, Ali, Rouchan, additional, Alinaiswe, Racheal, additional, Amaro, Helena M., additional, Anand, Santosh, additional, Assunção, Joana, additional, Ayesiga, Innocent, additional, Baviskar, Kiran D., additional, Bhardwaj, Monika, additional, Bhargava, Samir, additional, Billowria, Koushal, additional, Bisht, Dheeraj, additional, Boakye, Yaw Duah, additional, Boamah, Vivian Etsiapa, additional, Catarina Guedes, A., additional, Chauhan, Durgesh Nandini, additional, Chauhan, Nagendra Singh, additional, Chawla, Pooja A., additional, Chawla, Viney, additional, da Costa, Vivaldo Gomes, additional, Das, Sanghita, additional, Dey, Anindita, additional, Dey, Sumanta, additional, Farkhondeh, Tahereh, additional, Grover, Parul, additional, Gupta, Ruchi, additional, Gupta, Rupa, additional, Iqbal, Shabnoor, additional, Ishwarya, Ramachandran, additional, Jain, Ashish, additional, Kahwa, Ivan, additional, Khusro, Ameer, additional, Kori, Mohan Lal, additional, Kulshrestha, Mayank Krishna, additional, Kumar, Anoop, additional, Kumar, Ram, additional, Lodhi, Santram, additional, Majumder, Madhumita, additional, Malviya, Neelesh, additional, Malviya, Sapna, additional, Mapossa, António B., additional, Mbabazi, Rachel, additional, Mehta, Lovekesh, additional, Minz, Sunita, additional, Mishra, Prabhakar, additional, Nakalema, Sharon, additional, Nandy, Ashesh, additional, Nandy, Papiya, additional, Oteng-Amankwah, Esther Afua, additional, Patil, Umesh Kumar, additional, Pradhan, Madhulika, additional, Prasad, Awdhesh, additional, Rajput, Devyani, additional, Ramachandra, R., additional, Rana, Vijay Singh, additional, Sahibzada, Muhammad Umar Khayam, additional, Saivish, Marielena Vogel, additional, Samarghandian, Saeed, additional, Santharam, Katta, additional, Saxena, Rajiv, additional, Sethiya, Neeraj Kumar, additional, Shah, Kamal, additional, Shaikh, Tanvir Yusuf, additional, Sharma, Neelima, additional, Sharma, Prasanti, additional, Sharma, Shubham, additional, Shrivastava, Manindra Mohan, additional, Singh, Deependra, additional, Singh, Manju Rawat, additional, Sitoe, Alcides, additional, Sukrutha, S.K., additional, Talebi, Marjan, additional, Talebi, Mohsen, additional, Tiwari, Rahul, additional, Tomar, Ritu, additional, Vaseeharan, Baskaralingam, additional, Wiwanitkit, Viroj, additional, Yadav, Krishna, additional, Yasri, Sora, additional, and Youssef, Fadia S., additional

Published
2023
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44. Role of Acorus calamus extract in reducing exosome secretion by targeting Rab27a and nSMase2: a therapeutic approach for breast cancer.

Author

Gupta, Sunny, Gupta, Shipra, Singh, Manju, and Patel, Ashok Kumar

Abstract

Background: Exosomes are extracellular vesicles released by cells that mediate intercellular communication and actively participate in cancer progression, metastasis, and regulation of immune response within the tumour microenvironment. Inhibiting exosome release from cancer cells could be employed as a therapeutic against cancer. Methods and results: In the present study, we have studied the effects of Acorus calamus in inhibiting exosome secretion via targetting Rab27a and neutral sphingomyelinase 2 (nSMase2) in HER2-positive (MDA-MB-453), hormone receptor-positive (MCF-7) and triple-negative breast cancer (MDA-MB-231) cells. We observed that treatment with A. calamus significantly downregulated the expression of Rab27a and nSMase2 in all tested cells. NTA analysis showed that inhibition of Rab27a and nSMase2 reduced exosome secretion from breast cancer cells. We conducted metabolic profiling of A. calamus extract to reveal the phytochemicals present and docked them on Rab27a and nSMase2 to decipher the compounds responsible for protein inhibition. Molecular dynamic simulations were conducted on lead compounds, and we observed that calcitriol lactone showed the most stable binding interactions with nSMase2. Treatment of breast cancer cells with calcitriol lactone significantly downregulated nSMase2 expression. Conclusions: Our study demonstrates that A. calamus significantly inhibits exosome secretion in HER2-positive, hormone receptor-positive, and triple-negative breast cancer cells by targeting key regulatory proteins Rab27a and neutral sphingomyelinase 2 (nSMase2). These findings suggest that A. calamus holds therapeutic potential in inhibiting exosome-mediated cancer progression by targeting the exosome secretion pathway. Further investigations are warranted to explore the clinical applications of these findings in breast cancer treatment. [ABSTRACT FROM AUTHOR]

Published
2025
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48. Fabrication of Hydroxyapatite-Chitosan-Silk Fibroin Based Composite Film as Bone Tissue Regeneration Material

Author

Gupta, Sharda, Mukherjee, Rupsha, Jangle, Rajendra Kumar, Singh, Deependra, Singh, Manju, Bit, Arindam, Lovell, Nigel H., Advisory Editor, Oneto, Luca, Advisory Editor, Piotto, Stefano, Advisory Editor, Rossi, Federico, Advisory Editor, Samsonovich, Alexei V., Advisory Editor, Babiloni, Fabio, Advisory Editor, Liwo, Adam, Advisory Editor, Magjarevic, Ratko, Advisory Editor, Rizvanov, Albert A., editor, Singh, Bikesh Kumar, editor, and Ganasala, Padma, editor

Published
2021
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