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258 results on '"Singh, Chanchal"'

15. Effects of Lead: Neurological and Cellular Perspective

Author

Singh, Chanchal, Singh, Raghubir, Shekhar, Apoorva, Bennett, Erin R., Series Editor, Panagiotakis, Iraklis, Series Editor, Chrysochoou, Maria, Advisory Editor, Dermatas, Dimitris, Advisory Editor, di Palma, Luca, Advisory Editor, Lekkas, Demetris Francis, Advisory Editor, Menone, Mirta, Advisory Editor, Metcalfe, Chris, Advisory Editor, Moore, Matthew, Advisory Editor, Kumar, Nitish, editor, and Jha, Amrit Kumar, editor

Published
2024
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17. Neurotoxic Effect of Lead: A Review

Author

Singh, Chanchal, Shekhar, Apoorva, Singh, Raghubir, Förstner, Ulrich, Series Editor, Rulkens, Wim H., Series Editor, Kumar, Nitish, editor, and Jha, Amrit Kumar, editor

Published
2023
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22. Revisiting Utility of Fetal Autopsy in Genomic Era.

Author

Thakur, Seema, Singh, Chanchal, Paliwal, Preeti, Appannagri, Vrunda, Mohit, N., Chawla, Gurnihal Singh, and Bagga, Rounak

Subjects
*GENETIC counseling, *FETAL abnormalities, *AUTOPSY, *MEDICAL personnel, *HUMAN abnormalities
Abstract

AbstractBackground: Autopsy has been a gold standard in cases of antenatal detected anomalies or fetal demise. This helped clinicians in getting insights into the future management. In current times, ultrasound and genomic testing has become extremely powerful in further refining the etiological basis; however, fetal autopsy still has its role even now. Material and Methods: We have discussed the utility of fetal autopsy in current times by diving the cases in seven groups. Results: Case based discussions to discuss the utility of fetal autopsy. Conclusions: We suggest that fetal autopsy should be the standard of care in case of any abnormal fetal outcomes alongwith fetal genomic testing. Fetal autopsy is complementary to the ultrasound assessment and genomic investigations in reaching the final diagnosis and provides invaluable information regarding recurrence risk which may not be available when couple plans next pregnancy. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Comprehensive post-mortem evaluation in Intrauterine deaths /still births in improving uptake of autopsy and future pregnancy outcomes

Author

Thakur, Seema, primary, Kadam, Khushboo, additional, Paliwal, Preeti, additional, Singh, Shubhnita, additional, Singh, Chanchal, additional, Gupta, Rachna, additional, Dagar, Savita, additional, Jain, Sudhir, additional, Sharma, Akshatha, additional, Saxena, Renu, additional, Saxena, Kamal, additional, Kohli, Sudha, additional, Thareja, Vandana, additional, Saxena, Rajni, additional, Caprihan, Renu, additional, Grover, Vimal, additional, Bhutani, Manorma, additional, Gupta, Anita, additional, Kumar, Neena, additional, Gupta, Vandana, additional, Mittal, Mamta, additional, Verma, Sunita, additional, Jain, Arpana, additional, Chakerverty, Jyoti, additional, Kapila, Mukta, additional, Mittal, Swati, additional, Kapoor, Sunita, additional, and Khurana, Deepa, additional

Published
2024
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37. Benzothiazole: Synthetic Strategies, Biological Potential, and Interactions with Targets

Author

Salahuddin, Kumar Rajnish, Mishra Shivali, Mustqeem Abdullah Mohd., Mazumder Avijit, Kumar Ajay, Sahu Rakesh, and Singh Chanchal

Subjects
chemistry.chemical_compound, Benzothiazole, chemistry, Organic Chemistry, Biological potential, Combinatorial chemistry
Abstract

Benzothiazole is a heterocyclic compound that contains a benzene ring fused with a five-member 1,3-thiazole ring. Several types of research have established its potential as an antimicrobial agent, anticancer agent, anti-epileptic agent, antiviral agent, etc. Nowadays, various effective drugs utilize the hybridization of two or more pharmacophores in a single-molecule for synergizing its pharmacological action or to interact with more than one target or to reduce the side effects associated with it. In this article, various strategies for the synthesis of different pharmacologically active hybrid compounds containing benzothiazole with different substituents are highlighted. Apart from presenting the synthesis strategies, the article also highlights various pharmacological actions and molecular interactions with different biological molecules of the potential drugs containing benzothiazole.

Published
2022

38. Anti-Diabetic Potentials of Thiazolidinedione Analogues with Efficient Synthetic Procedures: A Review of Literature

Author

Kumar Ajay, Sahu Rakesh, Kumar Rajnish, Mishra Shivali, Salahuddin, Tiglani Devleena, and Singh Chanchal

Subjects
Chemistry, medicine.drug_class, Organic Chemistry, medicine, Thiazolidinedione, Combinatorial chemistry
Abstract

Background:: Diabetes mellitus refers to one of the leading cause of diseases that affect large populations of human and is characterized by a high glucose level in the blood (also known as hyperglycemia). Thiazolidinedione (TZD) is a five-member heterocyclic compound consisting of three carbons, nitrogen and sulfur. It is also known as glitazones, can be used as potent hypoglycemic agents and is also reduce many other cardiovascular risk factors including percutaneous coronary intervention, carotid and coronary atherosclerosis. As it plays a very important role in the field of medicinal chemistry or pharmaceutical sciences, novel medicine developed and many are on underdevelopment, these derivatives have thiazolidinedione as their primary nucleus. Objective:: This article has discussed the different synthetic procedures of thiazolidinediones that exhibited potential antidiabetic activity by the activation of PPAR-γ, by reducing the blood glucose levels and by different metabolic process incorporation. Conclusion:: Thiazolidinediones has effective profile as the future investigational drug and can be processed in drug discovery because of its efficient anti-diabetic potential.

Published
2022

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