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: Introduction: Children who are HIV‐exposed and uninfected (CHEU) are a growing population at potential risk of poor neurocognitive development. We tested a nurturing care intervention on children's neurocognitive development and maternal depressive symptoms (primary) with mediation through caregiving activities (secondary). Methods: This study was conducted among six intervention and nine comparison antenatal‐care/prevention of vertical transmission (ANC/PVT) HIV clinics in eSwatini. We enrolled pregnant women and measured infant development at 9 and 18 months. mothers2mothers (m2m) designed and implemented the clinic‐home‐community‐based intervention. We measured infants’ neurodevelopment, maternal depressive symptoms and caregiving activities with the Mullen Scales of Early Learning (MSEL), Edinburgh Postnatal Depression Scale, HOME Inventory and Family Care Indicators. We fitted linear mixed effects regression models with clinic random effects to compare intervention versus comparison arms, and generalised structural equation models to evaluate mediation, adjusting for confounders. Results: Mother‐infant pairs (n = 429) participated between January 2016 through May 2018. Socio‐demographic characteristics were balanced between arms except for higher rates of peri‐urban versus rural residence and single versus married mothers in the comparison group. The 18 month retention was 82% (180/220) intervention, 79% (166/209) comparison arm, with 25 infant deaths. Intervention MSEL scores were significantly, and modestly, higher in receptive language (55.7 [95% CI 54.6, 56.9] vs. 53.7 [95% CI 52.6, 54.8]), expressive language (42.5 [95% CI 41.6, 39.8] vs. 40.8 [95% CI 39.8, 41.7]) and composite MSEL (85.4 [95% CI 83.7, 84.5] vs. 82.7 [95% CI 81.0, 84.5]), with no difference in maternal depressive symptoms or in observations of mother‐child interactions. Intervention book‐sharing scores were higher (0.63 vs. 0.41) and mediated the effect on MSEL scores (indirect effect, p‐values ≤ 0.024). The direct effects on visual reception and expressive language scores were significantly higher in the intervention compared to the comparison arm (coefficients 1.93 [95% CI 0.26, 3.60] and 1.66 [95% CI 0.51, 2.79, respectively]). Conclusions: Nurturing care interventions can be integrated into ANC/PVT clinic‐home‐community programmes. The intervention, mediated through interactive caregiving activities, increased language development scores among CHEU. Partnering with a local team, m2m, to design and implement a culturally relevant intervention illustrates the ability to impact parent‐child play and learning activities that are associated with children's neurodevelopment., INTRODUCTION Paediatric HIV acquisitions have declined significantly, largely due to the expansion of antenatal‐care/prevention of vertical transmission (ANC/PVT) programmes [1]. The population of children who are HIV‐exposed and uninfected (CHEU) [...]

Background: Track PCC includes five geographic surveillance sites to conduct standardized population-based surveillance to estimate and track Post-COVID Conditions (PCC) by age, sex, race/ethnicity, geographic area, severity of initial infection, and risk factors among persons with evidence of SARS-CoV-2 infection (based on the Council of State and Territorial Epidemiologist [CSTE] case definitions for confirmed cases or laboratory-confirmed evidence of infection). Methods: The study will estimate the incidence, prevalence, including temporal trends, and duration and severity of PCC symptoms, among children, adolescents, and adults. PCCs include a broad range of symptoms and conditions that continue or develop after acute SARS-CoV-2 infection or COVID-19 illness. Surveillance includes both passive and active components for diverse populations in Arizona, Indiana, and Utah as well as the Bronx Borough, NY, and part of Philadelphia County, PA. Passive surveillance will utilize electronic health records and health information exchanges within each site catchment area to longitudinally follow persons with COVID-19 to estimate PCC occurring at least 30 days after acute COVID-19 illness. Active surveillance will utilize self-report of PCCs from detailed surveys of persons ages 7 years and older with evidence of SARS-CoV-2 infection in the past 3 months. Respondents will complete follow-up surveys at 6-, 12- and 18-months post-infection. Discussion: These data can help identify which groups are most affected by PCC, and what health differences among demographic groups exist, as well as indicate potential barriers to care. These additional levels of granularity can inform public health action and help direct needed clinical care for patients. [ABSTRACT FROM AUTHOR]

Background: Self-efficacy is an important predictor of performing health behaviors. Purpose: We invoked varying points of view (none, first person, third person) in standard instructions for breast self-exams (BSEs) to examine whether point of view taken would impact self-efficacy for and behavioral intentions regarding BSE. Methods: One hundred twenty women took part in an experiment that included reading instructions for proper performance of BSE. Measures of constructs from several common models used to predict health behavior (theory of reasoned action, theory of planned behavior, health belief model, and health action process approach) were also included. Results: Compared to a control group who did not read about performing BSE, standard instructions and third-person instructions predicted self-efficacy but first-person instructions did not. Further, barriers to and attitudes toward performing BSE were related to self-efficacy and self-efficacy, objective risk, past BSE behavior, and attitude were related to behavioral intentions. Discussion: Our results suggest that adopting a third-person perspective can increase self-efficacy for performing BSE. Translation to Health Education Practice: Given the relative ease with which point-of-view manipulations can be implemented, Health Educators should explore the utility of point of view in the practice of other health behaviors.

Background: Bangladesh introduced the 10-valent pneumococcal conjugate vaccine (PCV-10) in 2015. We measured population-based incidence of invasive pneumococcal disease (IPD) prior to introduction of PCV-10 to provide a benchmark against which the impact of PCV-10 can be assessed. Methods: We conducted population, facility and laboratory-based surveillance in children 0–59 months of age in three rural sub-districts of Sylhet district of Bangladesh from January 2014 to June 2015. All children received two-monthly home visits with one week recall for morbidity and care seeking. Children attending the three Upazilla Health Complexes (UHC, sub-district hospitals) in the surveillance area were screened for suspected IPD. Blood samples were collected from suspected IPD cases for culture and additionally, cerebrospinal fluid (CSF) was collected from suspected meningitis cases for culture and molecular testing. Pneumococcal isolates were serotyped by Quellung. Serotyping of cases detected by molecular testing was done by sequential multiplex polymerase chain reaction. Results: Children under surveillance contributed to 126,657 child years of observations. Sixty-three thousand three hundred eighty-four illness episodes were assessed in the UHCs. Blood specimens were collected from 8,668 suspected IPD cases and CSF from 177 suspected meningitis cases. Streptococcus pneumoniae was isolated from 46 cases; 32 (70%) were vaccine serotype. The population-based incidence of IPD was 36.3/100,000 child years of observations. About 80% of the cases occurred in children below two years of age. Discussion: IPD was common in rural Bangladesh suggesting the potential benefit of an effective vaccine. Measurement of the burden of IPD requires multiple surveillance modalities. [ABSTRACT FROM AUTHOR]

Background: Self-efficacy is an important predictor of performing health behaviors.Purpose: We invoked varying points of view (none, first person, third person) in standard instructions for breast self-exams (BSEs) to examine whether point of view taken would impact self-efficacy for and behavioral intentions regarding BSE.Methods: One hundred twenty women took part in an experiment that included reading instructions for proper performance of BSE. Measures of constructs from several common models used to predict health behavior (theory of reasoned action, theory of planned behavior, health belief model, and health action process approach) were also included.Results: Compared to a control group who did not read about performing BSE, standard instructions and third-person instructions predicted self-efficacy but first-person instructions did not. Further, barriers to and attitudes toward performing BSE were related to self-efficacy and self-efficacy, objective risk, past BSE behavior, and attitude were related to behavioral intentions.Discussion: Our results suggest that adopting a third-person perspective can increase self-efficacy for performing BSE.Translation to Health Education Practice: Given the relative ease with which point-of-view manipulations can be implemented, Health Educators should explore the utility of point of view in the practice of other health behaviors. [ABSTRACT FROM PUBLISHER]