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2. Tobacco smoke exposure, the lower airways microbiome and outcomes of ventilated children

Author

Leroue, Matthew K., Williamson, Kayla M., Curtin, Paul C., Sontag, Marci K., Wagner, Brandie D., Ambroggio, Lilliam, Bixby, Moira, Busgang, Stefanie A., Murphy, Sharon E., Peterson, Lisa A., Vevang, Karin R., Sipe, Christopher J., Kirk Harris, J., Reeder, Ron W., Locandro, Christopher, Carpenter, Todd C., Maddux, Aline B., Simões, Eric A. F., Osborne, Christina M., Robertson, Charles E., Langelier, Charles, Carcillo, Joseph A., Meert, Kathleen L., Pollack, Murray M., McQuillen, Patrick S., and Mourani, Peter M.

Published
2023
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4. Molecular and phenotypic characteristics of RSV infections in infants during two nirsevimab randomized clinical trials

Author

Ahani, Bahar, Tuffy, Kevin M., Aksyuk, Anastasia A., Wilkins, Deidre, Abram, Michael E., Dagan, Ron, Domachowske, Joseph B., Guest, Johnathan D., Ji, Hong, Kushnir, Anna, Leach, Amanda, Madhi, Shabir A., Mankad, Vaishali S., Simões, Eric A. F., Sparklin, Benjamin, Speer, Scott D., Stanley, Ann Marie, Tabor, David E., Hamrén, Ulrika Wählby, Kelly, Elizabeth J., and Villafana, Tonya

Published
2023
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5. Global disease burden of and risk factors for acute lower respiratory infections caused by respiratory syncytial virus in preterm infants and young children in 2019: a systematic review and meta-analysis of aggregated and individual participant data

Author

Arruda, Eurico, Baillie, Vicky L, Chong, Debora, Crow, Rowena, Filho, Nelson Rosário, Laubscher, Marius, Madhi, Shabir A, Mrcela, Dina, Ramilo, Octavio, Roje, Damir, Stein, Renato Tetelbom, Yung, Chee Fu, Wang, Xin, Li, You, Shi, Ting, Bont, Louis J, Chu, Helen Y, Zar, Heather J, Wahi-Singh, Bhanu, Ma, Yiming, Cong, Bingbing, Sharland, Emma, Riley, Richard D, Deng, Jikui, Figueras-Aloy, Josep, Heikkinen, Terho, Jones, Marcus H, Liese, Johannes G, Markić, Joško, Mejias, Asuncion, Nunes, Marta C, Resch, Bernhard, Satav, Ashish, Yeo, Kee Thai, Simões, Eric A F, and Nair, Harish

Published
2024
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6. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis

Author

Abram, Michael, Aerssens, Jeroen, Alafaci, Annette, Balmaseda, Angel, Bandeira, Teresa, Barr, Ian, Batinović, Ena, Beutels, Philippe, Bhiman, Jinal, Blyth, Christopher C, Bont, Louis, Bressler, Sara S, Cohen, Cheryl, Cohen, Rachel, Costa, Anna-Maria, Crow, Rowena, Daley, Andrew, Dang, Duc-Anh, Demont, Clarisse, Desnoyers, Christine, Díez-Domingo, Javier, Divarathna, Maduja, du Plessis, Mignon, Edgoose, Madeleine, Ferolla, Fausto Martín, Fischer, Thea K, Gebremedhin, Amanuel, Giaquinto, Carlo, Gillet, Yves, Hernandez, Roger, Horvat, Come, Javouhey, Etienne, Karseladze, Irakli, Kubale, John, Kumar, Rakesh, Lina, Bruno, Lucion, Florencia, MacGinty, Rae, Martinon-Torres, Federico, McMinn, Alissa, Meijer, Adam, Milić, Petra, Morel, Adrian, Mulholland, Kim, Mungun, Tuya, Murunga, Nickson, Newbern, Claire, Nicol, Mark P, Odoom, John Kofi, Openshaw, Peter, Ploin, Dominique, Polack, Fernando P, Pollard, Andrew J, Prasad, Namrata, Puig-Barberà, Joan, Reiche, Janine, Reyes, Noelia, Rizkalla, Bishoy, Satao, Shilpa, Shi, Ting, Sistla, Sujatha, Snape, Matthew, Song, Yanran, Soto, Giselle, Tavakoli, Forough, Toizumi, Michiko, Tsedenbal, Naranzul, van den Berge, Maarten, Vernhes, Charlotte, von Mollendorf, Claire, Walaza, Sibongile, Walker, Gregory, Li, You, Wang, Xin, Blau, Dianna M, Caballero, Mauricio T, Feikin, Daniel R, Gill, Christopher J, Madhi, Shabir A, Omer, Saad B, Simões, Eric A F, Campbell, Harry, Pariente, Ana Bermejo, Bardach, Darmaa, Bassat, Quique, Casalegno, Jean-Sebastien, Chakhunashvili, Giorgi, Crawford, Nigel, Danilenko, Daria, Do, Lien Anh Ha, Echavarria, Marcela, Gentile, Angela, Gordon, Aubree, Heikkinen, Terho, Huang, Q Sue, Jullien, Sophie, Krishnan, Anand, Lopez, Eduardo Luis, Markić, Joško, Mira-Iglesias, Ainara, Moore, Hannah C, Moyes, Jocelyn, Mwananyanda, Lawrence, Nokes, D James, Noordeen, Faseeha, Obodai, Evangeline, Palani, Nandhini, Romero, Candice, Salimi, Vahid, Satav, Ashish, Seo, Euri, Shchomak, Zakhar, Singleton, Rosalyn, Stolyarov, Kirill, Stoszek, Sonia K, von Gottberg, Anne, Wurzel, Danielle, Yoshida, Lay-Myint, Yung, Chee Fu, Zar, Heather J, and Nair, Harish

Published
2022
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7. Upper airway gene expression shows a more robust adaptive immune response to SARS-CoV-2 in children

Author

Mick, Eran, Tsitsiklis, Alexandra, Spottiswoode, Natasha, Caldera, Saharai, Serpa, Paula Hayakawa, Detweiler, Angela M., Neff, Norma, Pisco, Angela Oliveira, Li, Lucy M., Retallack, Hanna, Ratnasiri, Kalani, Williamson, Kayla M., Soesanto, Victoria, Simões, Eric A. F., Smith, Christiana, Abuogi, Lisa, Kistler, Amy, Wagner, Brandie D., DeRisi, Joseph L., Ambroggio, Lilliam, Mourani, Peter M., and Langelier, Charles R.

Published
2022
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9. Bivalent Omicron BA.4/BA.5 BNT162b2 Vaccine in 6-Month- to <12-Year-Olds.

Author

Sher, Lawrence D, Boakye-Appiah, Justice K, Hill, Sungeen, Wasserman, Emily, Xu, Xia, Maldonado, Yvonne, Walter, Emmanuel B, Muñoz, Flor M, Paulsen, Grant C, Englund, Janet A, Talaat, Kawsar R, Barnett, Elizabeth D, Kamidani, Satoshi, Senders, Shelly, Simões, Eric A F, Belanger, Kelly, Parikh, Vrunda, Ma, Hua, Wang, Xingbin, and Lu, Claire

Subjects
IMMUNIZATION, PATIENT safety, RESEARCH funding, COVID-19 vaccines, DESCRIPTIVE statistics, VACCINE immunogenicity, DRUG efficacy, CHILDREN
Abstract

Background With the future epidemiology and evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uncertain, the use of safe and effective coronavirus disease 2019 (COVID-19) vaccines in pediatric populations remains important. Methods We report data from two open-label substudies of an ongoing phase 1/2/3 master study (NCT05543616) investigating the safety and immunogenicity of a variant-adapted bivalent COVID-19 vaccine encoding ancestral and Omicron BA.4/BA.5 spike proteins (bivalent BNT162b2). The open-label groups presented here evaluate dose 4 with bivalent BNT162b2 in 6-month- to <12-year-olds who previously received three original (monovalent) BNT162b2 doses. In 6-month- to <5-year-olds, primary immunogenicity objectives were to demonstrate superiority (neutralizing titer) and noninferiority (seroresponse rate) to Omicron BA.4/BA.5 and noninferiority (neutralizing titer and seroresponse rate) to SARS-CoV-2 ancestral strains in participants who received bivalent BNT162b2 dose 4 compared with a matched group who received three doses of original BNT162b2 in the pivotal pediatric study (NCT04816643). In 5- to <12-year-olds, primary immunogenicity comparisons were descriptive. Reactogenicity and safety following vaccination were evaluated. Results In 6-month- to <5-year-olds, dose 4 with bivalent BNT162b2 met predefined immunogenicity superiority and noninferiority criteria against Omicron BA.4/BA.5 and ancestral strains when compared with dose 3 of original BNT162b2. In 5- to <12-year-olds, bivalent BNT162b2 induced robust Omicron BA.4/BA.5 and ancestral strain neutralizing titers comparable with dose 3 of original BNT162b2. The safety profile for dose 4 of bivalent BNT162b2 given as dose 4 was consistent with that of original BNT162b2 in 6-month- to <12-year-olds. Reactogenicity events were generally mild to moderate. No adverse events led to discontinuation. Conclusions These safety and immunogenicity data support a favorable benefit-risk profile for a variant-adapted BNT162b2 in children <12 years old. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Risk factors for the development of severe or very severe respiratory syncytial virus‐related lower respiratory tract infection in Indian infants: A cohort study in Melghat, India.

Author

Crow, Rowena, Satav, Ashish, Potdar, Varsha, Satav, Shilpa, Dani, Vibhawari, and Simões, Eric A. F.

Subjects
RESPIRATORY infections, RURAL poor, HUMAN metapneumovirus infection, RESPIRATORY syncytial virus infections, COHORT analysis, INFANTS
Abstract

Objectives: Respiratory syncytial virus (RSV) is undoubtedly the single most important cause of severe lower respiratory tract infection (LRTI) globally. While new prevention measures in young infants have become available, their use in developing countries is likely many years away. While risk factors for severe or very severe RSV LRTI in impoverished rural areas likely differ to urban areas, there are very few studies, especially those conducted in India, the major country contributing to the global burden of disease. Methods: Active surveillance for acute LRTI in enrolled infants and children <2 years of age, was conducted through weekly home visits in 93 villages of Melghat, India, from August 2016 to December 2020. Local hospitals and primary health centres were surveyed for admissions of enrolled subjects. Nasopharyngeal swabs were collected from children with severe, or very severe LRTIs and all who died, with RSV testing using nucleic acid tests at ICMR, National Institute of Virology Pune. Risk factors for both RSV associated and non‐RSV associated, severe and very severe LRTI were identified through univariate and multivariate logistic regression. Results: There were 483 severe or very severe RSV LRTI cases and 2807 non‐RSV severe or very severe LRTI infections in a cohort of 13,318 children. Weight for age z‐score ≤−2, the use of kerosene or wood for cooking, obtaining drinking water from a public tap and low gestational age significantly increased the risk of RSV LRTI. A higher wealth score index and water purification were protective. Comparison with non‐RSV LRTI showed male sex as an additional risk factor. The analysis highlighted the risk of kerosene use [OR = 17.8 (3.0–104.4) (p ≤ 0.001)] and [OR = 3.4 (0.8–14.4) (p ≤ 0.05)] for RSV and non‐RSV LRTIs, respectively. Conclusions: Nutritional status and environmental air quality are predisposing factors for developing an RSV LRI in young children, factors which are amenable to environmental and behavioural interventions. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Global disease burden of and risk factors for acute lower respiratory infections caused by respiratory syncytial virus in preterm infants and young children in 2019: a systematic review and meta-analysis of aggregated and individual participant data

Author

Wang, Xin, primary, Li, You, additional, Shi, Ting, additional, Bont, Louis J, additional, Chu, Helen Y, additional, Zar, Heather J, additional, Wahi-Singh, Bhanu, additional, Ma, Yiming, additional, Cong, Bingbing, additional, Sharland, Emma, additional, Riley, Richard D, additional, Deng, Jikui, additional, Figueras-Aloy, Josep, additional, Heikkinen, Terho, additional, Jones, Marcus H, additional, Liese, Johannes G, additional, Markić, Joško, additional, Mejias, Asuncion, additional, Nunes, Marta C, additional, Resch, Bernhard, additional, Satav, Ashish, additional, Yeo, Kee Thai, additional, Simões, Eric A F, additional, Nair, Harish, additional, Arruda, Eurico, additional, Baillie, Vicky L, additional, Chong, Debora, additional, Crow, Rowena, additional, Filho, Nelson Rosário, additional, Laubscher, Marius, additional, Madhi, Shabir A, additional, Mrcela, Dina, additional, Ramilo, Octavio, additional, Roje, Damir, additional, Stein, Renato Tetelbom, additional, and Yung, Chee Fu, additional

Published
2024
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12. Global burden of acute lower respiratory infection associated with human parainfluenza virus in children younger than 5 years for 2018: a systematic review and meta-analysis

Author

Wang, Xin, Li, You, Deloria-Knoll, Maria, Madhi, Shabir A, Cohen, Cheryl, Arguelles, Vina Lea, Basnet, Sudha, Bassat, Quique, Brooks, W Abdullah, Echavarria, Marcela, Fasce, Rodrigo A, Gentile, Angela, Goswami, Doli, Homaira, Nusrat, Howie, Stephen R C, Kotloff, Karen L, Khuri-Bulos, Najwa, Krishnan, Anand, Lucero, Marilla G, Lupisan, Socorro, Mathisen, Maria, McLean, Kenneth A, Mira-Iglesias, Ainara, Moraleda, Cinta, Okamoto, Michiko, Oshitani, Histoshi, O'Brien, Katherine L, Owor, Betty E, Rasmussen, Zeba A, Rath, Barbara A, Salimi, Vahid, Sawatwong, Pongpun, Scott, J Anthony G, Simões, Eric A F, Sotomayor, Viviana, Thea, Donald M, Treurnicht, Florette K, Yoshida, Lay-Myint, Zar, Heather J, Campbell, Harry, and Nair, Harish

Published
2021
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13. Global burden of acute lower respiratory infection associated with human metapneumovirus in children under 5 years in 2018: a systematic review and modelling study

Author

Libster, Romina, Otieno, Grieven, Joundi, Imane, Broor, Shobha, Nicol, Mark, Amarchand, Ritvik, Shi, Ting, López-Labrador, F. Xavier, Baker, Julia M., Jamison, Alexandra, Choudekar, Avinash, Juvekar, Sanjay, Obermeier, Patrick, Schweiger, Brunhilde, Madrid, Lola, Thomas, Elizabeth, Lanaspa, Miguel, Nohynek, Hanna, Nokes, James, Werner, Marta, Danhg, Anh, Chadha, Mandeep, Puig-Barberà, Joan, Caballero, Mauricio T., Mathisen, Maria, Walaza, Sibongile, Hellferscee, Orienka, Laubscher, Matt, Higdon, Melissa M., Haddix, Meredith, Sawatwong, Pongpun, Baggett, Henry C., Seidenberg, Phil, Mwanayanda, Lawrence, Antonio, Martin, Ebruke, Bernard E., Adams, Tanja, Rahman, Mustafizur, Rahman, Mohammed Ziaur, Sow, Samboa O., Baillie, Vicky L., Workman, Lesley, Toizumi, Michiko, Tapia, Milagritos D., Nguyen, Thi hien anh, Morpeth, Susan, Wang, Xin, Li, You, Deloria-Knoll, Maria, Madhi, Shabir A, Cohen, Cheryl, Ali, Asad, Basnet, Sudha, Bassat, Quique, Brooks, W Abdullah, Chittaganpitch, Malinee, Echavarria, Marcela, Fasce, Rodrigo A, Goswami, Doli, Hirve, Siddhivinayak, Homaira, Nusrat, Howie, Stephen R C, Kotloff, Karen L, Khuri-Bulos, Najwa, Krishnan, Anand, Lucero, Marilla G, Lupisan, Socorro, Mira-Iglesias, Ainara, Moore, David P, Moraleda, Cinta, Nunes, Marta, Oshitani, Histoshi, Owor, Betty E, Polack, Fernando P, O'Brien, Katherine L, Rasmussen, Zeba A, Rath, Barbara A, Salimi, Vahid, Scott, J Anthony G, Simões, Eric A F, Strand, Tor A, Thea, Donald M, Treurnicht, Florette K, Vaccari, Linda C, Yoshida, Lay-Myint, Zar, Heather J, Campbell, Harry, and Nair, Harish

Published
2021
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14. Epidemiology of Medically Attended Respiratory Syncytial Virus Lower Respiratory Tract Infection in Japanese Children, 2011–2017.

Author

Simões, Eric A F, Botteman, Marc, and Chirikov, Viktor

Subjects
*HUMAN metapneumovirus infection, *RESPIRATORY syncytial virus, *RESPIRATORY infections, *JAPANESE people, *PREMATURE infants, *RESPIRATORY syncytial virus infections
Abstract

Background The objective was to report critical respiratory syncytial virus (RSV)–related epidemiological and healthcare resource utilization measures among Japanese children stratified by gestational and chronological age groups. Methods The JMDC (formerly the Japan Medical Data Center) was used to retrospectively identify infants with or without RSV infection (beginning between 1 February 2011 and 31 January 2016, with follow-up through 31 December 2017). The incidence of RSV medically attended lower respiratory tract infection (MALRI) was captured by flagging hospitalizations, outpatient, and emergency department/urgent care visits with an RSV diagnosis code during the season. Results Of 113 529 infants and children identified, 17 022 (15%) had an RSV MALRI (14 590 during the season). The RSV MALRI and hospitalization rates in the first 5 months were 14.3/100 child-years (CY) and 6.0/100 CY, respectively (13.4/100 and 5.8/100 CY for full-term infants and 20/100 and 6.8/100 CY for late preterm infants, respectively). Among those with ≥1 type of MALRI event during the RSV season, >80% of children had it by 24 months of chronological age, although this observation differed by prematurity status. Sixty percent of healthcare resource utilization measures started in the outpatient setting. Conclusions This study emphasizes the RSV burden in young children and critically highlights the data needed to make decisions about new preventive strategies. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Healthcare Utilization Among Infants Covered by Medicaid and Newly Diagnosed With Respiratory Syncytial Virus.

Author

Suh, Mina, Movva, Naimisha, Jiang, Xiaohui, Reichert, Heidi, Pastula, Susan T, Sacks, Naomi C, Frankenfeld, Cara, Fryzek, Jon P, and Simões, Eric A F

Subjects
RESPIRATORY syncytial virus, MEDICAID, CHILD health insurance, MYOCARDIAL infarction, INFANTS, BUSINESS insurance
Abstract

Background Infants covered by Medicaid have higher respiratory syncytial virus (RSV) hospitalization rates than those with commercial insurance, but findings are limited to the inpatient setting. This birth cohort study describes healthcare encounters for RSV across all settings among infants covered by Medicaid and the Children's Health Insurance Program. Methods Medicaid claims for infants born and residing in Arizona (AZ), California (CA), Florida (FL), Michigan (MI), North Carolina (NC), New York (NY), and Texas (TX) were analyzed for first diagnosis of RSV in 2016–2018 using International Classification of Diseases, Tenth Revision codes. Encounters on the day of first diagnosis were examined by setting in 7 states and by setting and race in CA, FL, and NC. Results A total of 80 945 infants were diagnosed with RSV in 7 states in 2016–2018. The highest encounter rates for first RSV diagnosis were in the emergency department (ED) in 5 states (11.0–33.4 per 1000 in AZ, CA, FL, MI, and NY) and outpatient setting in 2 states (54.8 and 68.5 per 1000 in TX and NC). Significantly higher outpatient encounter rates were found in CA and NC for White infants compared to non-White infants. In NC, ED encounter rates were significantly higher for non-White infants than White infants, whereas in CA, the rates were comparable. In these 2 states, hospitalization rates were similar across groups. In FL, compared with White infants, non-White infants had significantly higher encounter rates in each setting on the day of first RSV diagnosis. Conclusions This is the first study to describe the burden of RSV by setting and race. Medicaid infants who are newly diagnosed with RSV have the highest burden in ED and outpatient settings. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Efficacy, duration of protection, birth outcomes, and infant growth associated with influenza vaccination in pregnancy: a pooled analysis of three randomised controlled trials

Author

Blackwelder, William, Bresee, Joseph, Coulibaly, Flanon, Diallo, Boubacar, Diallo, Fatoumata, Chen, Wilbur, Doumbia, Moussa, Haidara, Fadima Cheick, Keita, Adama Mamby, Klimov, Alexander, Kodio, Mamoudou, Kotloff, Karen, Levine, Myron M., Mishcherkin, Vladimir, Onwuchekwa, Uma, Panchalingam, Sandra, Pasetti, Marcela, Sanogo, Doh, Sow, Samba, Tapia, Milagritos, Tamboura, Boubou, Teguete, Ibrahim, Tennant, Sharon, Traore, Awa, Treanor, John, Englund, Janet A., Katz, Joanne, Khatry, Subarna K., Kuypers, Jane, LeClerq, Steven C., Mullany, Luke C., Shrestha, Laxman, Steinhoff, Mark C., Tielsch, James M., Adrian, Peter V., Cutland, Clare L., Hugo, Andrea, Jones, Stephanie, Kuwanda, Locadiah, Klugman, Keith P., Madhi, Shabir A., Neuzil, Kathleen M., van Niekerk, Nadia, Nunes, Marta C., Ortiz, Justin R., Simões, Eric A.F., Treurnicht, Florette, Venter, Marietjie, Violari, Avy, Weinberg, Adriana, Omer, Saad B, Clark, Dayna R, Madhi, Shabir A, Tapia, Milagritos D, Nunes, Marta C, Cutland, Clare L, Simões, Eric A F, Aqil, Anushka R, Tielsch, James M, Steinhoff, Mark C, and Wairagkar, Niteen

Published
2020
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18. Etiology of Acute Lower Respiratory Illness Hospitalizations Among Infants in 4 Countries

Author

Kubale, John, primary, Kujawski, Stephanie, additional, Chen, Irena, additional, Wu, Zhenke, additional, Khader, Ilham Abu, additional, Hasibra, Iris, additional, Whitaker, Brett, additional, Gresh, Lionel, additional, Simaku, Artan, additional, Simões, Eric A F, additional, Al-Gazo, Mahmoud, additional, Rogers, Shannon, additional, Gerber, Susan I, additional, Balmaseda, Angel, additional, Tallo, Veronica L, additional, Al-Sanouri, Tareq M, additional, Porter, Rachael, additional, Bino, Silvia, additional, Azziz-Baumgartner, Eduardo, additional, McMorrow, Meredith, additional, Hunt, Danielle, additional, Thompson, Mark, additional, Biggs, Holly M, additional, and Gordon, Aubree, additional

Published
2023
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19. Global patterns in monthly activity of influenza virus, respiratory syncytial virus, parainfluenza virus, and metapneumovirus: a systematic analysis

Author

Acacio, Sozinho, Alonso, Wladimir J, Antonio, Martin, Ayora Talavera, Guadalupe, Badarch, Darmaa, Baillie, Vicky L, Barrera-Badillo, Gisela, Bigogo, Godfrey, Broor, Shobha, Bruden, Dana, Buchy, Philippe, Byass, Peter, Chipeta, James, Clara, Wilfrido, Dang, Duc-Anh, de Freitas Lázaro Emediato, Carla Cecília, de Jong, Menno, Díaz-Quiñonez, José Alberto, Do, Lien Anh Ha, Fasce, Rodrigo A, Feng, Luzhao, Ferson, Mark J, Gentile, Angela, Gessner, Bradford D, Goswami, Doli, Goyet, Sophie, Grijalva, Carlos G, Halasa, Natasha, Hellferscee, Orienka, Hessong, Danielle, Homaira, Nusrat, Jara, Jorge, Kahn, Kathleen, Khuri-Bulos, Najwa, Kotloff, Karen L, Lanata, Claudio F, Lopez, Olga, Lopez Bolaños, Maria Renee, Lucero, Marilla G, Lucion, Florencia, Lupisan, Socorro P, Madhi, Shabir A, Mekgoe, Omphile, Moraleda, Cinta, Moyes, Jocelyn, Mulholland, Kim, Munywoki, Patrick K, Naby, Fathima, Nguyen, Thanh Hung, Nicol, Mark P, Nokes, D James, Noyola, Daniel E, Onozuka, Daisuke, Palani, Nandhini, Poovorawan, Yong, Rahman, Mustafizur, Ramaekers, Kaat, Romero, Candice, Schlaudecker, Elizabeth P, Schweiger, Brunhilde, Seidenberg, Phil, Simoes, Eric A F, Singleton, Rosalyn, Sistla, Sujatha, Sturm-Ramirez, Katharine, Suntronwong, Nungruthai, Sutanto, Agustinus, Tapia, Milagritos D, Thamthitiwat, Somsak, Thongpan, Ilada, Tillekeratne, Gayani, Tinoco, Yeny O, Treurnicht, Florette K, Turner, Claudia, Turner, Paul, van Doorn, Rogier, Van Ranst, Marc, Visseaux, Benoit, Waicharoen, Sunthareeya, Wang, Jianwei, Yoshida, Lay-Myint, Zar, Heather J, Li, You, Reeves, Rachel M, Wang, Xin, Bassat, Quique, Brooks, W Abdullah, Cohen, Cheryl, Moore, David P, Nunes, Marta, Rath, Barbara, Campbell, Harry, and Nair, Harish

Published
2019
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21. Viral Detection by Reverse Transcriptase Polymerase Chain Reaction in Upper Respiratory Tract and Metagenomic RNA Sequencing in Lower Respiratory Tract in Critically Ill Children With Suspected Lower Respiratory Tract Infection.

Author

Osborne, Christina M., Langelier, Charles, Kamm, Jack, Williamson, Kayla, Ambroggio, Lilliam, Reeder, Ron W., Locandro, Christopher, Harris, J. Kirk, Wagner, Brandie D., Maddux, Aline B., Caldera, Saharai, Lyden, Amy, Soesanto, Victoria, Simões, Eric A. F., Leroue, Matthew K., Carpenter, Todd C., Hall, Mark W., Zuppa, Athena F., Carcillo, Joseph A., and Meert, Kathleen L.

Published
2024
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25. Respiratory Syncytial Virus Vaccination During Pregnancy and Effects in Infants

Author

Madhi, Shabir A., Polack, Fernando P., Piedra, Pedro A., Munoz, Flor M., Trenholme, Adrian A., Simões, Eric A. F., Swamy, Geeta K., Agrawal, Sapeckshita, Ahmed, Khatija, August, Allison, Baqui, Abdullah H., Calvert, Anna, Chen, Janice, Cho, Iksung, Cotton, Mark F., Cutland, Clare L., Englund, Janet A., Fix, Amy, Gonik, Bernard, Hammitt, Laura, Heath, Paul T., de Jesus, Joanne N., Jones, Christine E., Khalil, Asma, Kimberlin, David W., Libster, Romina, Llapur, Conrado J., Lucero, Marilla, Pérez Marc, Gonzalo, Marshall, Helen S., Masenya, Masebole S., Martinón-Torres, Federico, Meece, Jennifer K., Nolan, Terry M., Osman, Ayman, Perrett, Kirsten P., Plested, Joyce S., Richmond, Peter C., Snape, Matthew D., Shakib, Julie H., Shinde, Vivek, Stoney, Tanya, Thomas, D. Nigel, Tita, Alan T., Varner, Michael W., Vatish, Manu, Vrbicky, Keith, Wen, Judy, Zaman, Khalequ, Zar, Heather J., Glenn, Gregory M., and Fries, Louis F.

Published
2021
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26. Global respiratory syncytial virus-associated mortality in young children (RSV GOLD): a retrospective case series

Author

Scheltema, Nienke M, Gentile, Angela, Lucion, Florencia, Nokes, D James, Munywoki, Patrick K, Madhi, Shabir A, Groome, Michelle J, Cohen, Cheryl, Moyes, Jocelyn, Thorburn, Kentigern, Thamthitiwat, Somsak, Oshitani, Hitoshi, Lupisan, Socorro P, Gordon, Aubree, Sánchez, José F, O'Brien, Katherine L, Gessner, Bradford D, Sutanto, Agustinus, Mejias, Asuncion, Ramilo, Octavio, Khuri-Bulos, Najwa, Halasa, Natasha, de-Paris, Fernanda, Pires, Márcia Rosane, Spaeder, Michael C, Paes, Bosco A, Simões, Eric A F, Leung, Ting F, da Costa Oliveira, Maria Tereza, de Freitas Lázaro Emediato, Carla Cecília, Bassat, Quique, Butt, Warwick, Chi, Hsin, Aamir, Uzma Bashir, Ali, Asad, Lucero, Marilla G, Fasce, Rodrigo A, Lopez, Olga, Rath, Barbara A, Polack, Fernando P, Papenburg, Jesse, Roglić, Srđan, Ito, Hisato, Goka, Edward A, Grobbee, Diederick E, Nair, Harish, and Bont, Louis J

Published
2017
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27. Identifying Gaps in Respiratory Syncytial Virus Disease Epidemiology in the United States Prior to the Introduction of Vaccines

Author

Kim, Lindsay, Rha, Brian, Abramson, Jon S., Anderson, Larry J., Byington, Carrie L., Chen, Grace L., DeVincenzo, John, Edwards, Kathryn M., Englund, Janet A., Falsey, Ann R., Griffin, Marie R., Karron, Ruth A., Martin, Karen G., Meissner, H. Cody, Munoz, Flor M., Pavia, Andrew T., Piedra, Pedro A., Schaffner, William, Simões, Eric A. F., Singleton, Rosalyn, Talbot, H. Keipp, Walsh, Edward E., Zucker, Jane R., and Gerber, Susan I.

Published
2017

30. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study

Author

Shi, Ting, McAllister, David A, O'Brien, Katherine L, Simoes, Eric A F, Madhi, Shabir A, Gessner, Bradford D, Polack, Fernando P, Balsells, Evelyn, Acacio, Sozinho, Aguayo, Claudia, Alassani, Issifou, Ali, Asad, Antonio, Martin, Awasthi, Shally, Awori, Juliet O, Azziz-Baumgartner, Eduardo, Baggett, Henry C, Baillie, Vicky L, Balmaseda, Angel, Barahona, Alfredo, Basnet, Sudha, Bassat, Quique, Basualdo, Wilma, Bigogo, Godfrey, Bont, Louis, Breiman, Robert F, Brooks, W Abdullah, Broor, Shobha, Bruce, Nigel, Bruden, Dana, Buchy, Philippe, Campbell, Stuart, Carosone-Link, Phyllis, Chadha, Mandeep, Chipeta, James, Chou, Monidarin, Clara, Wilfrido, Cohen, Cheryl, de Cuellar, Elizabeth, Dang, Duc-Anh, Dash-yandag, Budragchaagiin, Deloria-Knoll, Maria, Dherani, Mukesh, Eap, Tekchheng, Ebruke, Bernard E, Echavarria, Marcela, de Freitas Lázaro Emediato, Carla Cecília, Fasce, Rodrigo A, Feikin, Daniel R, Feng, Luzhao, Gentile, Angela, Gordon, Aubree, Goswami, Doli, Goyet, Sophie, Groome, Michelle, Halasa, Natasha, Hirve, Siddhivinayak, Homaira, Nusrat, Howie, Stephen R C, Jara, Jorge, Jroundi, Imane, Kartasasmita, Cissy B, Khuri-Bulos, Najwa, Kotloff, Karen L, Krishnan, Anand, Libster, Romina, Lopez, Olga, Lucero, Marilla G, Lucion, Florencia, Lupisan, Socorro P, Marcone, Debora N, McCracken, John P, Mejia, Mario, Moisi, Jennifer C, Montgomery, Joel M, Moore, David P, Moraleda, Cinta, Moyes, Jocelyn, Munywoki, Patrick, Mutyara, Kuswandewi, Nicol, Mark P, Nokes, D James, Nymadawa, Pagbajabyn, da Costa Oliveira, Maria Tereza, Oshitani, Histoshi, Pandey, Nitin, Paranhos-Baccalà, Gláucia, Phillips, Lia N, Picot, Valentina Sanchez, Rahman, Mustafizur, Rakoto-Andrianarivelo, Mala, Rasmussen, Zeba A, Rath, Barbara A, Robinson, Annick, Romero, Candice, Russomando, Graciela, Salimi, Vahid, Sawatwong, Pongpun, Scheltema, Nienke, Schweiger, Brunhilde, Scott, J Anthony G, Seidenberg, Phil, Shen, Kunling, Singleton, Rosalyn, Sotomayor, Viviana, Strand, Tor A, Sutanto, Agustinus, Sylla, Mariam, Tapia, Milagritos D, Thamthitiwat, Somsak, Thomas, Elizabeth D, Tokarz, Rafal, Turner, Claudia, Venter, Marietjie, Waicharoen, Sunthareeya, Wang, Jianwei, Watthanaworawit, Wanitda, Yoshida, Lay-Myint, Yu, Hongjie, Zar, Heather J, Campbell, Harry, and Nair, Harish

Published
2017
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32. Efficacy of nirsevimab against respiratory syncytial virus lower respiratory tract infections in preterm and term infants, and pharmacokinetic extrapolation to infants with congenital heart disease and chronic lung disease: a pooled analysis of randomised controlled trials

Author

Simões, Eric A F, primary, Madhi, Shabir A, additional, Muller, William J, additional, Atanasova, Victoria, additional, Bosheva, Miroslava, additional, Cabañas, Fernando, additional, Baca Cots, Manuel, additional, Domachowske, Joseph B, additional, Garcia-Garcia, Maria L, additional, Grantina, Ineta, additional, Nguyen, Kim A, additional, Zar, Heather J, additional, Berglind, Anna, additional, Cummings, Celeste, additional, Griffin, M Pamela, additional, Takas, Therese, additional, Yuan, Yuan, additional, Wählby Hamrén, Ulrika, additional, Leach, Amanda, additional, and Villafana, Tonya, additional

Published
2023
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33. Additional file 3 of Community—Minimal Invasive Tissue Sampling (cMITS) using a modified ambulance for ascertaining the cause of death: A novel approach piloted in a remote inaccessible rural area in India

Author

Satav, Ashish, Wairagkar, Niteen, Khirwadkar, Shubhada, Dani, Vibhawari, Rasaily, Reeta, Agrawal, Usha, Thakar, Yagnesh, Raje, Dhananjay, Siraj, Fouzia, Garge, Pradyot, Palaskar, Sameer, Kumbhare, Shraddha, and Simões, Eric A. F.

Abstract

Additional file 3: Annexure 3: MITS Ambulance Set up.

Published
2023
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34. Additional file 8 of Community—Minimal Invasive Tissue Sampling (cMITS) using a modified ambulance for ascertaining the cause of death: A novel approach piloted in a remote inaccessible rural area in India

Author

Satav, Ashish, Wairagkar, Niteen, Khirwadkar, Shubhada, Dani, Vibhawari, Rasaily, Reeta, Agrawal, Usha, Thakar, Yagnesh, Raje, Dhananjay, Siraj, Fouzia, Garge, Pradyot, Palaskar, Sameer, Kumbhare, Shraddha, and Simões, Eric A. F.

Abstract

Additional file 8: Annexure 8: Verbal autopsy form for death of people in age group of 16-60 years.

Published
2023
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35. Additional file 1 of Community—Minimal Invasive Tissue Sampling (cMITS) using a modified ambulance for ascertaining the cause of death: A novel approach piloted in a remote inaccessible rural area in India

Author

Satav, Ashish, Wairagkar, Niteen, Khirwadkar, Shubhada, Dani, Vibhawari, Rasaily, Reeta, Agrawal, Usha, Thakar, Yagnesh, Raje, Dhananjay, Siraj, Fouzia, Garge, Pradyot, Palaskar, Sameer, Kumbhare, Shraddha, and Simões, Eric A. F.

Abstract

Additional file 1: Annexure 1: Standard operating procedure (SOP) for grief counselling MITS in MAHAN.

Published
2023
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36. Additional file 2 of Community—Minimal Invasive Tissue Sampling (cMITS) using a modified ambulance for ascertaining the cause of death: A novel approach piloted in a remote inaccessible rural area in India

Author

Satav, Ashish, Wairagkar, Niteen, Khirwadkar, Shubhada, Dani, Vibhawari, Rasaily, Reeta, Agrawal, Usha, Thakar, Yagnesh, Raje, Dhananjay, Siraj, Fouzia, Garge, Pradyot, Palaskar, Sameer, Kumbhare, Shraddha, and Simões, Eric A. F.

Abstract

Additional file 2: Annexure 2: MITS Ambulance sterilisation SOP.

Published
2023
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37. Additional file 6 of Community—Minimal Invasive Tissue Sampling (cMITS) using a modified ambulance for ascertaining the cause of death: A novel approach piloted in a remote inaccessible rural area in India

Author

Satav, Ashish, Wairagkar, Niteen, Khirwadkar, Shubhada, Dani, Vibhawari, Rasaily, Reeta, Agrawal, Usha, Thakar, Yagnesh, Raje, Dhananjay, Siraj, Fouzia, Garge, Pradyot, Palaskar, Sameer, Kumbhare, Shraddha, and Simões, Eric A. F.

Abstract

Additional file 6: Annexure 6: Verbal autopsy form for neonatal deaths (0 to 28 days).

Published
2023
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38. Additional file 9 of Community—Minimal Invasive Tissue Sampling (cMITS) using a modified ambulance for ascertaining the cause of death: A novel approach piloted in a remote inaccessible rural area in India

Author

Satav, Ashish, Wairagkar, Niteen, Khirwadkar, Shubhada, Dani, Vibhawari, Rasaily, Reeta, Agrawal, Usha, Thakar, Yagnesh, Raje, Dhananjay, Siraj, Fouzia, Garge, Pradyot, Palaskar, Sameer, Kumbhare, Shraddha, and Simões, Eric A. F.

Abstract

Additional file 9: Annexure 9: Tangerine Software.

Published
2023
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39. Additional file 7 of Community—Minimal Invasive Tissue Sampling (cMITS) using a modified ambulance for ascertaining the cause of death: A novel approach piloted in a remote inaccessible rural area in India

Author

Satav, Ashish, Wairagkar, Niteen, Khirwadkar, Shubhada, Dani, Vibhawari, Rasaily, Reeta, Agrawal, Usha, Thakar, Yagnesh, Raje, Dhananjay, Siraj, Fouzia, Garge, Pradyot, Palaskar, Sameer, Kumbhare, Shraddha, and Simões, Eric A. F.

Abstract

Additional file 7: Annexure 7: Verbal autopsy form of post neonatal under 5 children’s deaths.

Published
2023
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40. Additional file 4 of Community—Minimal Invasive Tissue Sampling (cMITS) using a modified ambulance for ascertaining the cause of death: A novel approach piloted in a remote inaccessible rural area in India

Author

Satav, Ashish, Wairagkar, Niteen, Khirwadkar, Shubhada, Dani, Vibhawari, Rasaily, Reeta, Agrawal, Usha, Thakar, Yagnesh, Raje, Dhananjay, Siraj, Fouzia, Garge, Pradyot, Palaskar, Sameer, Kumbhare, Shraddha, and Simões, Eric A. F.

Abstract

Additional file 4: Annexure 4: Minimally Invasive Tissue Sampling SOP MAHAN.

Published
2023
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42. Respiratory Syncytial Virus Infection Among Hospitalized Infants in Four Middle-Income Countries.

Author

Biggs, Holly M, Simões, Eric A F, Khader, Ilham Abu, Thompson, Mark G, Gordon, Aubree, Hunt, Danielle R, DeGroote, Nicholas P, Porter, Rachael M, Bino, Silvia, Marar, Basima I, Gresh, Lionel, Jesus-Cornejo, Joanne de, Langley, Gayle, Thornburg, Natalie J, Peret, Teresa C T, Whitaker, Brett, Zhang, Yange, Wang, Lijuan, Patel, Mira C, and McMorrow, Meredith

Subjects
*INTENSIVE care units, *REVERSE transcriptase polymerase chain reaction, *PATIENT aftercare, *MIDDLE-income countries, *CONFIDENCE intervals, *HOSPITAL care of newborn infants, *ACQUISITION of data, *INTERVIEWING, *COMPARATIVE studies, *LOW-income countries, *MEDICAL records, *HOSPITAL care, *RESEARCH funding, *RESPIRATORY syncytial virus infections, *LOGISTIC regression analysis, *ODDS ratio, *LONGITUDINAL method
Abstract

Background Understanding respiratory syncytial virus (RSV) global epidemiology is important to inform future prevention strategies. Methods Hospitalized infants <1-year-old with acute illness were enrolled prospectively in Albania, Jordan, Nicaragua, and Philippines during respiratory seasons in 2015–2017. Medical chart review, parental interview, and post-discharge follow up were conducted. Respiratory specimens were tested using real-time RT-PCR for RSV. Infant characteristics associated with very severe illness (intensive care unit [ICU] admission or receipt of supplemental oxygen) were assessed using logistic regression to adjust for potential confounders (age, sex, study site, and preterm birth). Results Of 3634 enrolled hospitalized infants, 1129 (31%) tested positive for RSV. The median age of RSV-positive infants was 2.7 (IQR: 1.4–6.1) months and 665 (59%) were male. Very severe illness in 583 (52%) RSV-positive infants was associated with younger age (aOR 4.1, 95% CI: 2.6–6.5 for 0–2 compared to 9–11-months; P <.01), low weight-for-age z -score (aOR 1.9, 95% CI: 1.2–2.8; P <.01), ICU care after birth (aOR 1.6, 95% CI: 1.0–2.5; P =.048), and cesarean delivery (aOR 1.4, 95% CI: 1.0–1.8; P =.03). RSV subgroups A and B co-circulated at all sites with alternating predominance by year; subgroup was not associated with severity (aOR 1.0, 95% CI: 0.8–1.4). Nine (0.8%) RSV-positive infants died during admission or within ≤30 days of discharge, of which 7 (78%) were <6-months-old. Conclusions RSV was associated with nearly a third of infant acute illness hospitalizations in four middle-income countries during the respiratory season, where, in addition to young age, factors including low weight-for-age might be important predictors of severity. RSV prevention strategies targeting young infants could substantially reduce RSV-associated hospitalizations in middle-income countries. [ABSTRACT FROM AUTHOR]

Published
2023
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43. Integrated Host/Microbe Metagenomics Enables Accurate Lower Respiratory Tract Infection Diagnosis in Critically Ill Children

Author

Mick, Eran, primary, Tsitsiklis, Alexandra, additional, Kamm, Jack, additional, Kalantar, Katrina L., additional, Caldera, Saharai, additional, Lyden, Amy, additional, Tan, Michelle, additional, Detweiler, Angela M., additional, Neff, Norma, additional, Osborne, Christina M., additional, Williamson, Kayla M., additional, Soesanto, Victoria, additional, Leroue, Matthew, additional, Maddux, Aline B., additional, Simões, Eric A. F., additional, Carpenter, Todd C., additional, Wagner, Brandie D., additional, DeRisi, Joseph L., additional, Ambroggio, Lilliam, additional, Mourani, Peter M., additional, and Langelier, Charles R., additional

Published
2022
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44. 91. Establishing Proof of Concept for a Bivalent RSVpreF Subunit Vaccine for Maternal Immunization

Author

Simões, Eric A F, primary, Madhi, Shabir A, additional, Center, Kimberly J, additional, Llapur, Conrado J, additional, Novoa Pizarro, Jose M, additional, Swanson, Kena A, additional, Radley, David, additional, McGrory, Stephanie B, additional, Gomme, Emily A, additional, Scott, Daniel A, additional, Jansen, Kathrin U, additional, Gruber, William C, additional, and Gurtman, Alejandra C, additional

Published
2022
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45. Identifying the research, advocacy, policy and implementation needs for the prevention and management of respiratory syncytial virus lower respiratory tract infection in low- and middle-income countries

Author

Carbonell-Estrany, Xavier, primary, Simões, Eric A. F, additional, Bont, Louis J, additional, Gentile, Angela, additional, Homaira, Nusrat, additional, Scotta, Marcelo Comerlato, additional, Stein, Renato T, additional, Torres, Juan P, additional, Sheikh, Jarju, additional, Broor, Shobha, additional, Khuri-Bulos, Najwa, additional, Nokes, D James, additional, Munywoki, Patrick K, additional, Bassat, Quique, additional, Sharma, Arun K, additional, Basnet, Sudha, additional, Garba, Maria, additional, De Jesus-Cornejo, Joanne, additional, Lupisan, Socorro P, additional, Nunes, Marta C, additional, Divarathna, Maduja, additional, Fullarton, John R, additional, Rodgers-Gray, Barry S, additional, Keary, Ian, additional, Reñosa, Mark Donald C, additional, Verwey, Charl, additional, Moore, David P, additional, Noordeen, Faseeha, additional, Kabra, Sushil, additional, do Vale, Marynéa Silva, additional, Paternina-De La Ossa, Rolando, additional, Mariño, Cristina, additional, Figueras-Aloy, Josep, additional, Krilov, Leonard, additional, Berezin, Eitan, additional, Zar, Heather J, additional, Paudel, Krishna, additional, Safadi, Marco Aurelio Palazzi, additional, Dbaibo, Ghassan, additional, Jroundi, Imane, additional, Jha, Runa, additional, Rafeek, Rukshan A. M, additional, Pinheiro, Rossiclei de Souza, additional, Bracht, Marianne, additional, Muthugala, Rohitha, additional, Lanari, Marcello, additional, Martinón-Torres, Federico, additional, Mitchell, Ian, additional, Irimu, Grace, additional, Pandey, Apsara, additional, Krishnan, Anand, additional, Mejias, Asuncion, additional, da Costa, Marcela Santos Corrêa, additional, Shrestha, Shrijana, additional, Pernica, Jeffrey M, additional, de Carvalho, Felipe Cotrim, additional, Jalango, Rose E, additional, Ibrahim, Hafsat, additional, Ewa, Atana, additional, Ensinck, Gabriela, additional, Ulloa-Gutierrez, Rolando, additional, Miralha, Alexandre Lopes, additional, Lucion, Maria Florencia, additional, Hassan, Md Zakiul, additional, Akhtar, Zubair, additional, Aleem, Mohammad Abdul, additional, Chowdhury, Fahmida, additional, Rojo, Pablo, additional, Sande, Charles, additional, Musau, Abednego, additional, Zaman, Khalequ, additional, Helena, Luiza, additional, Arlant, Falleiros, additional, Ghimire, Prakash, additional, Price, April, additional, Subedi, Kalpana Upadhyay, additional, Brenes-Chacon, Helena, additional, Goswami, Doli Rani, additional, Rahman, Mohammed Ziaur, additional, Hossain, Mohammad Enayet, additional, Chisti, Mohammod Jobayer, additional, Vain, Nestor E, additional, Lim, Audrey, additional, Chiu, Aaron, additional, Papenburg, Jesse, additional, Juarez, Maria del Valle, additional, Senaratne, Thamarasi, additional, Arunasalam, Shiyamalee, additional, Strand, Tor A, additional, Ayuk, Adaeze, additional, Ogunrinde, Olufemi, additional, Tavares, Lohanna Valeska de Sousa, additional, Garba, Comfort, additional, Garba, Bilkisu I, additional, Dawa, Jeanette, additional, Gordon, Michelle, additional, Osoro, Eric, additional, Agoti, Charles N, additional, Nyawanda, Bryan, additional, Ngama, Mwanajuma, additional, Tabu, Collins, additional, Mathew, Joseph L, additional, Cornacchia, Andrew, additional, Rai, Ganesh Kumar, additional, Jain, Amita, additional, Giongo, Mateus Sfoggia, additional, and Paes, Bosco A, additional

Published
2022
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