577 results on '"Shoemaker J"'
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2. Rapid changes in cerebrovascular compliance during vasovagal syncope
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Shoemaker, Leena N., Sajid, Aleena, Schondorf, Ronald, and Shoemaker, J. Kevin
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- 2024
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3. A century of exercise physiology: key concepts in neural control of the circulation
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Shoemaker, J. Kevin and Gros, Robert
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- 2024
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4. Standing middle cerebral artery velocity predicts cognitive function and gait speed in older adults with cognitive impairment, and is impacted by sex differences
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Fitzgibbon-Collins, Laura K, Coombs, Geoff B, Noguchi, Mamiko, Parihar, Shashankdhwaj, Hughson, Richard L, Borrie, Michael, Peters, Sue, Shoemaker, J Kevin, and Bhangu, Jaspreet
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- 2024
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5. Factors Associated With Large Improvements in Health-Related Quality of Life in Patients With Atrial Fibrillation
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Steinberg, Benjamin A, Holmes, DaJuanicia N, Pieper, Karen, Allen, Larry A, Chan, Paul S, Ezekowitz, Michael D, Freeman, James V, Fonarow, Gregg C, Gersh, Bernard J, Hylek, Elaine M, Kowey, Peter R, Mahaffey, Kenneth W, Naccarelli, Gerald, Reiffel, James, Singer, Daniel E, Peterson, Eric D, Piccini, Jonathan P, Mendelson, R, Nahhas, A, Neutel, J, Padanilam, B, Pan, D, Poock, J, Raffetto, J, Greengold, R, Roan, P, Saba, F, Sackett, M, Schneider, R, Seymour, Z, Shanes, J, Shoemaker, J, Simms, V, Smiley, N, Smith, D, Snipes, C, Sotolongo, R, Staniloae, C, Stoltz, S, Suresh, DP, Tak, T, Tannenbaum, A, Turk, S, Vora, K, Randhawa, P, Zebrack, J, Silva, E, Riley, E, Weinstein, D, Vasiliauskas, T, Goldbarg, S, Hayward, D, Yarlagadda, C, Laurion, D, Osunkoya, A, Burns, R, Castor, T, Spiller, D, Luttman, C, Anton, S, McGarvey, J, Guthrie, R, Deriso, G, Flood, R, Fleischer, L, Fierstein, JS, Aggarwal, R, Jacobs, G, Adjei, N, Akyea-Djamson, A, Alfieri, A, Bacon, J, Bedwell, N, Berger, P, Berry, J, Bhagwat, R, Bloom, S, Boccalandro, F, Capo, J, Kapadia, S, Casanova, R, Morriss III, JE, Christensen, T, Elsen, J, Farsad, R, Fox, D, Frandsen, B, Gelernt, M, Gill, S, Grubb, S, Hall, C, Harris, H, Hotchkiss, D, Ip, J, Jaffrani, N, Jones, A, Kazmierski, J, Waxman, F, Kneller, GL, and Labroo, A
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Biomedical and Clinical Sciences ,Clinical Sciences ,Heart Disease ,Substance Misuse ,Genetics ,Health Services ,Cardiovascular ,Clinical Research ,Good Health and Well Being ,Aged ,Aged ,80 and over ,Anti-Arrhythmia Agents ,Atrial Fibrillation ,Catheter Ablation ,Comorbidity ,Electric Countershock ,Female ,Health Status ,Heart Rate ,Humans ,Male ,Outpatients ,Quality of Life ,Recovery of Function ,Registries ,Risk Factors ,Time Factors ,Treatment Outcome ,United States ,ORBIT-AF (Outcomes Registry for Better Informed Treatment of Atrial Fibrillation) Investigators and Patients ,atrial fibrillation ,cardiac resynchronization therapy ,health status ,patient-reported outcomes ,quality of life ,Cardiorespiratory Medicine and Haematology ,Medical Physiology ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology ,Clinical sciences ,Medical physiology - Abstract
BackgroundAtrial fibrillation (AF) adversely impacts health-related quality of life (hrQoL). While some patients demonstrate improvements in hrQoL, the factors associated with large improvements in hrQoL are not well described.MethodsWe assessed factors associated with a 1-year increase in the Atrial Fibrillation Effect on Quality-of-Life score of 1 SD (≥18 points; 3× clinically important difference), among outpatients in the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation I registry.ResultsOverall, 28% (181/636) of patients had such a hrQoL improvement. Compared with patients not showing large hrQoL improvement, they were of similar age (median 73 versus 74, P=0.3), equally likely to be female (44% versus 48%, P=0.3), but more likely to have newly diagnosed AF at baseline (18% versus 8%; P=0.0004), prior antiarrhythmic drug use (52% versus 40%, P=0.005), baseline antiarrhythmic drug use (34.8% versus 26.8%, P=0.045), and more likely to undergo AF-related procedures during follow-up (AF ablation: 6.6% versus 2.0%, P=0.003; cardioversion: 12.2% versus 5.9%, P=0.008). In multivariable analysis, a history of alcohol abuse (adjusted OR, 2.41; P=0.01) and increased baseline diastolic blood pressure (adjusted OR, 1.23 per 10-point increase and >65 mm Hg; P=0.04) were associated with large improvements in hrQoL at 1 year, whereas patients with prior stroke/transient ischemic attack, chronic obstructive pulmonary disease, and peripheral arterial disease were less likely to improve (P
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- 2020
6. Changes in Cognition and Brain Function After 26 Weeks of Progressive Resistance Training in Older Adults at Risk for Diabetes: A Pilot Randomized Controlled Trial
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Furlano, Joyla A., Horst, Becky R., Petrella, Robert J., Shoemaker, J. Kevin, and Nagamatsu, Lindsay S.
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- 2023
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7. The effects of slow breathing on postural muscles during standing perturbations in young adults
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Siedlecki, P., Ivanova, T. D., Shoemaker, J. K., and Garland, S. J.
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- 2022
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8. Born into an isolating world: family-centred care for babies born to mothers with COVID-19
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Dowse, G., Perkins, E.J., Tingay, D.G., De Luca, D., Stein, H.M., Carvalho, W.B., Danhaive, O., Elsayed, Y., Chidini, G., Kneyber, M.C.J., MedinaVillanueva, A., Polito, A., Shoemaker, J., Piersigilli, B., Bekkouch, O., Rooze, S., Gonçalves Ferri, W.A., Oliveira, A.A., Morello, R., Krebs, V., Buonsenso, D., Valentini, P., Al-Naqeeb, N., Sabbour, S.M.H., Hegazi, A.E.A., Torpiano, P., Sammut, P., Pace, D., Vetter-Laracy, S., Roldán, M., Pilar-Orive, F.J., Rogdo, B., Cetinkaya, M., Yasa, B., Letamendia-Richard, E., Regiroli, G., Vivanti, A., Centorrino, R., Oliveira, N.F., Dittrich, M.H.M., Felgueira, R., Neves, C., Tissieres, P., Amigoni, A., Daverio, M., Tosoni, A., Andre, M.C., Wagner, B., Riedel, T., Rimensberger, P., Ramelet, A.-S., Perez, M.-H., Marston, M., Chanez, V., Longchamp, D., Natterer, J., Ferry, T., Brotschi, B., Elsayed, Y.N., AlNaqeeb, N., Medina, A., and Brouwer, C.N.M.
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- 2023
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9. Impaired sympathetic neural recruitment during exercise pressor reflex activation in women with post-traumatic stress disorder
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D’Souza, Andrew W., Yoo, Jeung-Ki, Takeda, Ryosuke, Badrov, Mark B., Anderson, Elizabeth H., Wiblin, Jessica I., North, Carol S., Suris, Alina, Nelson, Michael D., Shoemaker, J. Kevin, and Fu, Qi
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- 2022
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10. Reshaping the path of mild cognitive impairment by refining exercise prescription: a study protocol of a randomized controlled trial to understand the “what,” “for whom,” and “how” of exercise to promote cognitive function
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Barha, Cindy K., Falck, Ryan S., Best, John R., Nagamatsu, Lindsay S., Hsiung, Ging-Yuek Robin, Sheel, A. William, Hsu, Chun Liang, Kramer, Arthur F., Voss, Michelle W., Erickson, Kirk I., Davis, Jennifer C., Shoemaker, J. Kevin, Boyd, Lara, Crockett, Rachel A., ten Brinke, Lisanne, Bherer, Louis, Singer, Joel, Galea, Liisa A. M., Jacova, Claudia, Bullock, Alexis, Grant, Sofia, and Liu-Ambrose, Teresa
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- 2022
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11. Interaction of simultaneous hypoxia and baroreflex loading on control of sympathetic action potential subpopulations.
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Boyes, Natasha G., Klassen, Stephen A., Baker, Sarah E., Nicholson, Wayne T., Joyner, Michael J., Shoemaker, J. Kevin, and Limberg, Jacqueline K.
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BARORECEPTORS ,REGULATION of blood pressure ,ACTION potentials ,SYMPATHETIC nervous system ,DIASTOLIC blood pressure - Abstract
Efferent muscle sympathetic nerve activity (MSNA) is under tonic baroreflex control. The arterial baroreflex exerts the strongest influence over medium-sized sympathetic action potential (AP) subpopulations in efferent MSNA recordings. Prior work from multiunit MSNA recordings has shown baroreflex loading selectively abolishes the sympathetic response to hypoxia. The purpose of the study was to examine baroreflex control over different-sized AP clusters and characterize the neural recruitment strategies of sympathetic AP subpopulations with baroreflex and combined baroreflex/chemoreflex (i.e., hypoxia) activation. We loaded the arterial baroreceptors [intravenous phenylephrine (PE)] alone and in combination with systemic hypoxia (S p O 2 80%) in nine healthy young men. We extracted sympathetic APs using the wavelet-based methodology and quantified baroreflex gain for individual AP clusters. AP baroreflex threshold gain was measured as the slope of the linear relationship between AP probability versus diastolic blood pressure for 10 normalized clusters. Baroreflex loading with phenylephrine decreased MSNA and AP firing compared with baseline (all P < 0.05). However, the phenylephrine-mediated decrease in AP firing was lost with concurrent hypoxia (P = 0.384). Compared with baseline, baroreflex loading reduced medium-sized AP cluster baroreflex threshold slope (condition P = 0.005) and discharge probability (condition P < 0.0001); these reductions from baseline were maintained during simultaneous hypoxia (both P < 0.05). Present findings indicate a key modulatory role of the baroreceptors on medium-sized APs in blood pressure regulation that withstands competing signals from peripheral chemoreflex activation. NEW & NOTEWORTHY: This study provides a novel understanding on baroreflex control of efferent sympathetic nervous system activity during competing stressors: baroreflex loading and peripheral chemoreflex activation. We show chemoreflex activation buffers baroreflex-mediated reductions in sympathetic nervous system activity. More importantly, baroreflex loading reduced baroreflex threshold gain of sympathetic action potential clusters and this reduction withstood chemoreflex activation. These data suggest the arterial baroreflex holds a primary regulatory role over medium-sized sympathetic neurons despite competing chemoreflex signals. [ABSTRACT FROM AUTHOR]
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- 2024
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12. No influence of steady-state postural changes on cerebrovascular compliance in humans.
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Kells, Alicia M., Moir, M. Erin, Coombs, Geoff B., D'Souza, Andrew W., Klassen, Stephen A., Al-Khazraji, Baraa K., and Shoemaker, J. Kevin
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BRAIN physiology ,CEREBRAL artery physiology ,RESEARCH funding ,STANDING position ,HEMODYNAMICS ,DESCRIPTIVE statistics ,VASCULAR resistance ,ARTERIAL pressure ,SUPINE position ,BLOOD flow measurement ,SITTING position ,BODY movement ,POSTURE ,CEREBRAL circulation ,BLOOD pressure ,COMPARATIVE studies ,BRACHIAL artery ,FOREARM - Abstract
The aim of this study was to determine the effect of posture changes on vascular compliance in intracranial (brain) versus extracranial vascular beds (forearm). Eighteen young adults (nine females) performed a supine-to-seated-to-standing protocol involving 5 min of rest in each position. Continuous blood pressure, middle cerebral artery (MCA) blood velocity, and brachial artery blood velocity were recorded at each posture. Three to five consecutive steady-state cardiac cycles at each posture were analyzed by a four-element lumped parameter modified Windkessel model to calculate vascular compliance. Mean arterial pressure (MAP) increased from supine to seated (76(9) vs. 81(12) mmHg; P = 0.006) and from supine to standing (76(9) vs. 82(13) mmHg; P = 0.034). Mean blood flow was greater in the MCA relative to the forearm (forearm: 40(5) mL·min
−1 , MCA: 224(17) mL·min−1 ; main effect P < 0.001). Conversely, vascular resistance (forearm: 3.25(0.50) mmHg−1 ·mL·min−1 , brain: 0.36(0.04) mmHg−1 ·mL·min−1 ; main effect P < 0.001) and compliance (forearm: 0.010(0.001) mL·min−1 ·mmHg−1 , brain: 0.005(0.001) mL·min−1 ·mmHg−1 ; main effect P = 0.001) were greater in the forearm compared to the brain. Significant main effects of posture were observed with decreasing values in upright positions for mean blood flow (P = 0.001) in both vascular beds, but not for resistance (P = 0.163) or compliance (P = 0.385). There were no significant interaction effects between vascular bed and posture for mean flow (P = 0.057), resistance (P = 0.258), or compliance (P = 0.329). This study provides evidence that under steady-state conditions, posture does not affect cerebrovascular compliance. [ABSTRACT FROM AUTHOR]- Published
- 2024
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13. Sympathetic Action Potential Firing and Recruitment Patterns Are Abnormal in Gestational Hypertension
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Badrov, Mark B., Yoo, Jeung-Ki, Hissen, Sarah L., Nelson, David B., Shoemaker, J. Kevin, and Fu, Qi
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- 2022
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14. Rapid Changes in Cerebrovascular Compliance During Vasovagal Syncope
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Shoemaker, Leena, primary, Sajid, Aleena, additional, Schondorf, Ronald, additional, and Shoemaker, J. Kevin, additional
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- 2024
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15. Coronary Artery Bypass Grafting After Orthotopic Heart Transplantation
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Chandrasekhar, S., primary, Agrawal, A., additional, Wu, R., additional, Shoemaker, J., additional, and Rinde-Hoffman, D., additional
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- 2024
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16. Central α2‐adrenergic mechanisms regulate human sympathetic neuronal discharge strategies.
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Klassen, Stephen A., Limberg, Jacqueline K., Harvey, Ronée E., Wiggins, Chad C., Iannarelli, Nathaniel J., Senefeld, Jonathon W., Nicholson, Wayne T., Curry, Timothy B., Joyner, Michael J., Shoemaker, J. Kevin, and Baker, Sarah E.
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ADRENERGIC mechanisms ,SYMPATHETIC nervous system ,SPLANCHNIC nerves ,DEXMEDETOMIDINE ,HEART beat - Abstract
The present study investigated the impact of central α2‐adrenergic mechanisms on sympathetic action potential (AP) discharge, recruitment and latency strategies. We used the microneurographic technique to record muscle sympathetic nerve activity and a continuous wavelet transform to investigate postganglionic sympathetic AP firing during a baseline condition and an infusion of a α2‐adrenergic receptor agonist, dexmedetomidine (10 min loading infusion of 0.225 µg kg−1; maintenance infusion of 0.1–0.5 µg kg h−1) in eight healthy individuals (28 ± 7 years, five females). Dexmedetomidine reduced mean pressure (92 ± 7 to 80 ± 8 mmHg, P < 0.001) but did not alter heart rate (61 ± 13 to 60 ± 14 bpm; P = 0.748). Dexmedetomidine reduced sympathetic AP discharge (126 ± 73 to 27 ± 24 AP 100 beats−1, P = 0.003) most strongly for medium‐sized APs (normalized cluster 2: 21 ± 10 to 5 ± 5 AP 100 beats−1; P < 0.001). Dexmedetomidine progressively de‐recruited sympathetic APs beginning with the largest AP clusters (12 ± 3 to 7 ± 2 clusters, P = 0.002). Despite de‐recruiting large AP clusters with shorter latencies, dexmedetomidine reduced AP latency across remaining clusters (1.18 ± 0.12 to 1.13 ± 0.13 s, P = 0.002). A subset of six participants performed a Valsalva manoeuvre (20 s, 40 mmHg) during baseline and the dexmedetomidine infusion. Compared to baseline, AP discharge (Δ 361 ± 292 to Δ 113 ± 155 AP 100 beats−1, P = 0.011) and AP cluster recruitment elicited by the Valsalva manoeuvre were lower during dexmedetomidine (Δ 2 ± 1 to Δ 0 ± 2 AP clusters, P = 0.041). The reduction in sympathetic AP latency elicited by the Valsalva manoeuvre was not affected by dexmedetomidine (Δ –0.09 ± 0.07 to Δ –0.07 ± 0.14 s, P = 0.606). Dexmedetomidine reduced baroreflex gain, most strongly for medium‐sized APs (normalized cluster 2: –6.0 ± 5 to –1.6 ± 2 % mmHg−1; P = 0.008). These data suggest that α2‐adrenergic mechanisms within the central nervous system modulate sympathetic postganglionic neuronal discharge, recruitment and latency strategies in humans. Key points: Sympathetic postganglionic neuronal subpopulations innervating the human circulation exhibit complex patterns of discharge, recruitment and latency. However, the central neural mechanisms governing sympathetic postganglionic discharge remain unclear.This microneurographic study investigated the impact of a dexmedetomidine infusion (α2‐adrenergic receptor agonist) on muscle sympathetic postganglionic action potential (AP) discharge, recruitment and latency patterns.Dexmedetomidine infusion inhibited the recruitment of large and fast conducting sympathetic APs and attenuated the discharge of medium sized sympathetic APs that fired during resting conditions and the Valsalva manoeuvre.Dexmedetomidine infusion elicited shorter sympathetic AP latencies during resting conditions but did not affect the reductions in latency that occurred during the Valsalva manoeuvre.These data suggest that α2‐adrenergic mechanisms within the central nervous system modulate sympathetic postganglionic neuronal discharge, recruitment and latency strategies in humans. [ABSTRACT FROM AUTHOR]
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- 2024
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17. Sympathetic baroreflex sensitivity is enhanced in postmenopausal women.
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McGinty, Shane J., Matthews, Evan L., Greaney, Jody L., Shoemaker, J. Kevin, and Wenner, Megan M.
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BAROREFLEXES ,POSTMENOPAUSE ,SYMPATHETIC nervous system ,HEART beat ,OLDER people - Abstract
The sympathetic nervous system is critical for regulating blood pressure (BP) via the arterial baroreflex and sympathetic transduction in the peripheral vasculature. These mechanisms interact, and both may be altered with aging and impacted by menopause. Although age-related decreases in sympathetic transduction have been demonstrated in women, it remains unclear whether sympathetic baroreflex sensitivity (BRS) is impaired in postmenopausal women (POST). We tested the hypothesis that sympathetic BRS would be enhanced in POST compared with premenopausal women (PRE). We examined beat-by-beat BP and muscle sympathetic nerve activity (MSNA) in 19 PRE (22 ± 2 yr, 22 ± 3 kg/m
2 ) and 12 POST (57 ± 5 yr, 24 ± 2 kg/m2 ) during 10 min of rest. Spontaneous sympathetic BRS was quantified as the slope of a linear regression between MSNA burst incidence and diastolic BP. Sympathetic transduction to mean arterial pressure (MAP) for the 10 cardiac cycles following spontaneous MSNA bursts was assessed via signal averaging method. Resting MAP was similar (PRE: 82 ± 8 vs. POST: 85 ± 8 mmHg, P = 0.43), whereas resting MSNA was elevated in POST (PRE: 10 ± 6 vs. POST: 45 ± 16 bursts/100 heart beats, P < 0.0001). Spontaneous sympathetic BRS was enhanced in POST (PRE: −2.0 ± 1.2 vs. POST: −5.2 ± 1.9 bursts/beat/mmHg, P < 0.0005). Sympathetic transduction to MAP was attenuated in POST (time: P < 0.001, group: P < 0.001, interaction: P < 0.01). These data suggest that sympathetic BRS may be enhanced in POST. Consistent with recent hypotheses, enhanced sensitivity of the arterial baroreflex's neural arc may signify a compensatory response to reduced efficiency of the peripheral arterial baroreflex arc (i.e., sympathetic transduction) to preserve BP buffering capacity. NEW & NOTEWORTHY: Studies examining sympathetic baroreflex function with aging remain equivocal, with some studies showing an increase, decrease, or no change in sympathetic baroreflex sensitivity (BRS) in older adults compared with younger adults. With aging, women experience unique physiological changes due to menopause that influence autonomic function. For the first time, we show that postmenopausal women exhibit a greater sympathetic BRS compared with young premenopausal women. [ABSTRACT FROM AUTHOR]- Published
- 2024
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18. Effects of biological sex and oral contraception on the sympathetic neurocirculatory adjustments to static handgrip exercise in humans
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D’Souza, Andrew W., primary, Hissen, Sarah L., additional, Manabe, Kazumasa, additional, Washio, Takuro, additional, Annis, Meghan C., additional, Sanchez, Belinda, additional, Fu, Qi, additional, and Shoemaker, J. Kevin, additional
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- 2023
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19. Insulin resistance without coexisting hyperglycaemia is not independently associated with cardiorespiratory fitness or its components in women
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Rissanen, A, primary, Rissanen, J, additional, Poyhonen-Alho, M, additional, Tiitinen, A, additional, Tikkanen, H O, additional, Shoemaker, J K, additional, Petrella, R, additional, and Peltonen, J E, additional
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- 2023
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20. Impact of ischemic heart disease and cardiac rehabilitation on cerebrovascular compliance
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Coombs, Geoff B., primary, Al-Khazraji, Baraa K., additional, Suskin, Neville, additional, and Shoemaker, J. Kevin, additional
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- 2023
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21. Characterization of cerebral macro- and microvascular hemodynamics during transient hypotension
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Shoemaker, Leena N., primary, Milej, Daniel, additional, Sajid, Aleena, additional, Mistry, Jigneshkumar, additional, Lawrence, Keith St, additional, and Shoemaker, J. Kevin, additional
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- 2023
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22. Age- and sex-specific differences in sympathetic vascular transduction and neuro-hemodynamic balance in humans
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D'Souza, Andrew W., primary, Hissen, Sarah L., additional, Manabe, Kazumasa, additional, Takeda, Ryosuke, additional, Washio, Takuro, additional, Coombs, Geoff B., additional, Sanchez, Belinda, additional, Fu, Qi, additional, and Shoemaker, J. Kevin, additional
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- 2023
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23. The effects of sex and menstrual cycle phase on sympathetic action potential recruitment patterns during hypercapnic-hypoxic apnea
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Coovadia, Yasmine, primary, Shoemaker, J. Kevin, additional, and Usselman, Charlotte W., additional
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- 2023
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24. Lower body negative pressure identifies altered central vein characteristics without accompanying changes to baroreflexes in astronauts within hours of landing.
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Mastrandrea, C. J., Greaves, D. K., Shoemaker, J. K., Blaber, A. P., Arbeille, P., and Hughson, R. L.
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BAROREFLEXES ,CENTRAL venous pressure ,DIASTOLIC blood pressure ,ASTRONAUTS ,SYSTOLIC blood pressure ,VEINS ,HEART beat - Abstract
Cardiovascular deconditioning and altered baroreflexes predispose returning astronauts to Orthostatic Intolerance. We assessed 7 astronauts (1 female) before and following long-duration spaceflight (146 ± 43 days) with minimal upright posture prior to testing. We applied lower body negative pressure (LBNP) of up to − 30 mmHg to supine astronauts instrumented for continual synchronous measurements of cardiovascular variables, and intermittent imaging the Portal Vein (PV) and Inferior Vena Cava (IVC). During supine rest without LBNP, postflight elevations to total peripheral resistance (TPR; 15.8 ± 4.6 vs. 20.8 ± 7.1 mmHg min/l, p < 0.05) and reductions in stroke volume (SV; 104.4 ± 16.7 vs. 87.4 ± 11.5 ml, p < 0.05) were unaccompanied by changes to heart rate (HR) or estimated central venous pressure (CVP). Small increases to systolic blood pressure (SBP) and diastolic blood pressure (DBP) were not statistically significant. Autoregressive moving average modelling (ARMA) during LBNP did not identify differences to either arterial (DBP → TPR and SBP → HR) or cardiopulmonary (CVP → TPR) baroreflexes consistent with intact cardiovascular control. On the other hand, IVC and PV diameter-CVP relationships during LBNP revealed smaller diameter for a given CVP postflight consistent with altered postflight venous wall dynamics. [ABSTRACT FROM AUTHOR]
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- 2024
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25. Influence of Sex and Age on Muscle Sympathetic Nerve Activity of Healthy Normotensive Adults
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Keir, Daniel A., Badrov, Mark B., Tomlinson, George, Notarius, Catherine F., Kimmerly, Derek S., Millar, Philip J., Shoemaker, J. Kevin, and Floras, John S.
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- 2020
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26. Qualification of Chemically Bonded Sand Systems Using a Casting Trial for Quantifying Interfacial Defects
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Ramrattan, S., Wells, L., Patel, P., and Shoemaker, J.
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- 2018
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27. Central alpha-2 adrenergic mechanisms affect human sympathetic neuronal discharge strategies
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Klassen, Stephen, primary, Limberg, Jacqueline, additional, Harvey, Ronee, additional, Wiggins, Chad, additional, Iannarelli, Nathaniel, additional, Senefeld, Jonathon, additional, Nicholson, Wayne, additional, Curry, Timothy, additional, Joyner, Michael, additional, Shoemaker, J. Kevin, additional, and Baker, Sarah, additional
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- 2023
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28. The interactive effects of age and sex on the neuro‐cardiovascular responses during fatiguing rhythmic handgrip exercise
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D'Souza, Andrew W., primary, Takeda, Ryosuke, additional, Manabe, Kazumasa, additional, Hissen, Sarah L., additional, Washio, Takuro, additional, Coombs, Geoff B., additional, Sanchez, Belinda, additional, Fu, Qi, additional, and Shoemaker, J. Kevin, additional
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- 2023
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29. Baroreflex resetting of human sympathetic action potential subpopulations during exercise
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Klassen, Stephen A., primary, Badrov, Mark B., additional, Moir, M. Erin, additional, and Shoemaker, J. Kevin, additional
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- 2023
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30. Sympathetic activity is not a main cause of blood pressure reduction with exercise training in un-medicated middle-aged/older men
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Ehlers, Thomas Svare, Møller, Sophie, Hansen, Camilla Collin, Tamariz-Ellemann, Andrea Sofia, Vermeulen, T D, Shoemaker, J K, Gliemann, Lasse, Hellsten, Ylva, Ehlers, Thomas Svare, Møller, Sophie, Hansen, Camilla Collin, Tamariz-Ellemann, Andrea Sofia, Vermeulen, T D, Shoemaker, J K, Gliemann, Lasse, and Hellsten, Ylva
- Abstract
Background: This study tested the hypothesis that training reduces resting sympathetic activity and improves baroreflex control in both hypertensive and normotensive men but reduces blood pressure only in hypertensive men.Methods: Middle-aged/older un-medicated stage-1 hypertensive males (mean age 55±3 yrs; n=13) and normotensive controls (mean age 60±5 yrs; n=12) participated in 8 weeks of supervised high-intensity interval spinning training. Before and after training, muscle sympathetic nerve activity (MSNA) and blood pressure were measured at rest and during a sympatho-excitatory cold pressor test (CPT). Based on the measurements, baroreceptor sensitivity and baroreceptor threshold were calculated.Results: Resting MSNA and baroreceptor sensitivity were similar for the hypertensive and the normotensive groups. Training lowered MSNA (p<0.05), expressed as burst frequency (burst/min), overall, and to a similar extent, in both groups (17 and 27%, respectively in hypertensive and normotensive group), whereas blood pressure was only significantly (p<0.05) lowered (by 4 mmHg in both systolic and diastolic pressure) in the hypertensive group. Training did not (p>0.05) alter the MSNA or blood pressure response to CPT or increase baroreceptor sensitivity but reduced (p<0.05) the baroreceptor threshold with a main effect for both groups. Training adherence and intensity was similar in both groups yet absolute maximal oxygen uptake increased by 15% in the normotensive group only.Conclusion: The dissociation between the training induced changes in resting MSNA, lack of change in baroreflex sensitivity and the change in blood pressure, suggests that MSNA is not a main cause of the blood pressure reduction with exercise training in un-medicated middle-aged/older men.
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- 2023
31. Reactivity of larger intracranial arteries using 7 T MRI in young adults
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Al-Khazraji, Baraa K, Shoemaker, Leena N, Gati, Joseph S, Szekeres, Trevor, and Shoemaker, J Kevin
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- 2019
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32. Age- and sex-related differences in sympathetic vascular transduction and neurohemodynamic balance in humans.
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D'Souza, Andrew W., Hissen, Sarah L., Kazumasa Manabe, Ryosuke Takeda, Takuro Washio, Coombs, Geoff B., Sanchez, Belinda, Qi Fu, and Shoemaker, J. Kevin
- Abstract
Bursts of muscle sympathetic nerve activity (MSNA) and the ensuing vasoconstriction are pivotal determinants of beat-by-beat blood pressure regulation. Although age and sex impact blood pressure regulation, how these factors affect the central and peripheral arcs of the baroreflex remains unclear. In 27 young [25 (SD 3) yr] males (YM; n = 14) and females (YF; n = 13) and 23 older [71 (SD 5) yr] males (OM; n = 11) and females (OF; n = 12), femoral artery blood flow, blood pressure, and MSNA were recorded for 10 min of supine rest. Sympathetic baroreflex sensitivity (i.e., central arc) was quantified as the relationship between diastolic blood pressure and MSNA burst incidence. Signal averaging was used to determine sympathetic vascular transduction into leg vascular conductance (LVC) for 12 cardiac cycles following MSNA bursts (i.e., peripheral arc). Older adults demonstrated attenuated sympathetic transduction into LVC (both P < 0.001) following MSNA bursts, and smaller increases in sympathetic transduction as a function of MSNA burst size and firing pattern compared with young adults (range, P = 0.004-0.032). YM (r² = 0.36; P = 0.032) and OM (r² = 0.51; P = 0.014) exhibited an inverse relationship between the central and peripheral arcs of the baroreflex, whereas females did not (YF, r² = 0.03, P = 0.621; OF, r² = 0.06, P = 0.445). MSNA burst incidence was inversely related to sympathetic transduction in YM and OF (range, P = 0.03-0.046) but not in YF or OM (range, P = 0.360-0.603). These data indicate that age is associated with attenuated sympathetic vascular transduction, whereas age- and sex-specific changes are present in the relationship between the central and peripheral arcs of the baroreflex regulation of blood pressure. [ABSTRACT FROM AUTHOR]
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- 2023
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33. Sympathetic Transduction to Blood Pressure During Euglycemic-Hyperinsulinemia in Young Healthy Adults: Role of Burst Amplitude
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Young, Benjamin E., primary, Padilla, Jaume, additional, Shoemaker, J. Kevin, additional, Curry, Timothy B., additional, Fadel, Paul J., additional, and Limberg, Jacqueline K., additional
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- 2023
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34. Muscle Sympathetic Action Potential Firing Patterns During Normotensive and Hypertensive Pregnancy: A Longitudinal Assessment
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Badrov, Mark B., primary, Yoo, Jeung-Ki, additional, Hissen, Sarah L., additional, D’Souza, Andrew W., additional, Nelson, David B., additional, Shoemaker, J. Kevin, additional, and Fu, Qi, additional
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- 2023
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35. Sympathetic Action Potential Firing and Recruitment Patterns Are Abnormal in Gestational Hypertension
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Badrov, Mark B., primary, Yoo, Jeung-Ki, additional, Hissen, Sarah L., additional, Nelson, David B., additional, Shoemaker, J. Kevin, additional, and Fu, Qi, additional
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- 2023
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36. Sympathetic activity is not a main cause of blood pressure reduction with exercise training in un‐medicated middle‐aged/older men
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Ehlers, Thomas S., primary, Møller, Sophie, additional, Hansen, Camilla C., additional, Tamariz‐Ellemann, Andrea S., additional, Vermeulen, Tyler D., additional, Shoemaker, J. Kevin, additional, Gliemann, Lasse, additional, and Hellsten, Ylva, additional
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- 2023
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37. Regulation of cerebrovascular compliance compared with forearm vascular compliance in humans: a pharmacological study
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Moir, M. Erin, primary, Klassen, Stephen A., additional, Zamir, Mair, additional, Hamner, J. W., additional, Tan, Can Ozan, additional, and Shoemaker, J. Kevin, additional
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- 2023
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38. The Effects of Sex and Pubertal Maturation on Cardiovagal Baroreflex Sensitivity
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Chirico, Daniele, Liu, Jian, Klentrou, Panagiota, Shoemaker, J. Kevin, and O'Leary, Deborah D.
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- 2015
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39. Early mobilization in the critical care unit: A review of adult and pediatric literature
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Cameron, Saoirse, Ball, Ian, Cepinskas, Gediminas, Choong, Karen, Doherty, Timothy J., Ellis, Christopher G., Martin, Claudio M., Mele, Tina S., Sharpe, Michael, Shoemaker, J. Kevin, and Fraser, Douglas D.
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- 2015
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40. Normal and excessive muscle sympathetic nerve activity in heart failure: implications for future trials of therapeutic autonomic modulation
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Badrov, Mark B., primary, Keir, Daniel A., additional, Tomlinson, George, additional, Notarius, Catherine F., additional, Millar, Philip J., additional, Kimmerly, Derek S., additional, Shoemaker, J. Kevin, additional, Keys, Evan, additional, and Floras, John S., additional
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- 2022
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41. Changes in cognition and brain function following 26 weeks of progressive resistance training in older adults at risk for diabetes: A pilot randomized controlled trial
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Furlano, Joyla A., Horst, Becky R., Petrella, Robert J., Shoemaker, J. Kevin, and Nagamatsu, Lindsay S.
- Abstract
© This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/. Deposited by shareyourpaper.org and openaccessbutton.org. We've taken reasonable steps to ensure this content doesn't violate copyright. However, if you think it does you can request a takedown by emailing help@openaccessbutton.org.
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- 2023
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42. Recruitment strategies in efferent sympathetic nerve activity
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Shoemaker, J. Kevin
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- 2017
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43. Metabolomics profiling of concussion in adolescent male hockey players: a novel diagnostic method
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Daley, Mark, Dekaban, Greg, Bartha, Robert, Brown, Arthur, Stewart, Tanya Charyk, Doherty, Timothy, Fischer, Lisa, Holmes, Jeff, Menon, Ravi S., Rupar, C. Anthony, Shoemaker, J. Kevin, and Fraser, Douglas D.
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- 2016
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44. Identifying Personality Characteristics and Indicators of Psychological Well-Being Associated With Attrition in the Motivation Makes the Move! Physical Activity Intervention: Randomized Technology-Supported Trial
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Kaseva, Kaisa, primary, Tervaniemi, Mari, additional, Heikura, Enni, additional, Kostilainen, Kaisamari, additional, Pöyhönen-Alho, Maritta, additional, Shoemaker, J Kevin, additional, Petrella, Robert J, additional, and Peltonen, Juha E, additional
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- 2022
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45. Neurocardiovascular Dysregulation During Orthostasis in Women With Posttraumatic Stress Disorder
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D’Souza, Andrew W., primary, Yoo, Jeung-Ki, additional, Takeda, Ryosuke, additional, Badrov, Mark B., additional, Anderson, Elizabeth H., additional, Washio, Takuro, additional, North, Carol S., additional, Suris, Alina, additional, Nelson, Michael D., additional, Shoemaker, J. Kevin, additional, and Fu, Qi, additional
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- 2022
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46. Influence of sex and age on the relationship between aerobic fitness and muscle sympathetic nerve activity in healthy adults
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Badrov, Mark B., primary, Keir, Daniel A., additional, Notarius, Catherine F., additional, O’Donnell, Emma, additional, Millar, Philip J., additional, Kimmerly, Derek S., additional, Shoemaker, J. Kevin, additional, and Floras, John S., additional
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- 2022
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47. CCISS, Vascular and BP Reg: Canadian space life science research on ISS
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Hughson, Richard L., Shoemaker, J. Kevin, and Arbeille, Philippe
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- 2014
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48. Stroke prevention in patients from Latin American countries with non‐valvular atrial fibrillation: Insights from the GARFIELD‐AF registry
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Jerjes-Sanchez C., Corbalan R., Barretto A. C. P., Luciardi H. L., Allu J., Illingworth L., Pieper K. S., Kayani G., Fitzmaurice D. A., Goto S., Hacke W., Mantovani L. G., Turpie A. G. G., Gersh B. J., Gibbs H., Brodmann M., Cools F., Connolly S. J., Spyropoulos A., Eikelboom J., Hu D., Jansky P., Nielsen J. D., Ragy H., Raatikainen P., Le Heuzey J. -Y., Darius H., Keltai M., Kakkar S., Sawhney J. P. S., Agnelli G., Ambrosio G., Koretsune Y., Diaz C. J. S., ten Cate H., Atar D., Stepinska J., Panchenko E., Lim T. W., Jacobson B., Oh S., Vinolas X., Rosenqvist M., Steffel J., Angchaisuksiri P., Parkhomenko A., Al Mahmeed W., Chen K. N., Zhao Y. S., Zhang H. Q., Chen J. Z., Cao S. P., Wang D. W., Yang Y. J., Li W. H., Yin Y. H., Tao G. Z., Yang P., Chen Y. M., He S. H., Wang Y., Fu G. S., Li X., Wu T. G., Cheng X. S., Yan X. W., Zhao R. P., Chen M. S., Xiong L. G., Chen P., Jiao Y., Guo Y., Xue L., Wang F. Z., Li H., Yang Z. M., Bai C. L., Chen J., Chen J. Y., Chen X., Feng S., Fu Q. H., Gao X. J., Guo W. N., He R. H., He X. A., Hu X. S., Huang X. F., Li B., Li J., Li L., Li Y. H., Liu T. T., Liu W. L., Liu Y. Y., Lu Z. C., Luo X. L., Ma T. Y., Peng J. Q., Sheng X., Shi X. J., Sun Y. H., Tian G., Wang K., Wang L., Wu R. N., Xie Q., Xu R. Y., Yang J. S., Yang L. L., Yang Q., Ye Y., Yu H. Y., Yu J. H., Yu T., Zhai H., Zhan Q., Zhang G. S., Zhang Q., Zhang R., Zhang Y., Zheng W. Y., Zhou B., Zhou Z. H., Zhu X. Y., Jadhav P., Durgaprasad R., Ravi Shankar A. G., Rajput R. K., Bhargava K., Sarma R., Srinivas A., Roy D., Nagamalesh U. M., Chopda M., Kishore R., Kulkarni G., Chandwani P., Pothiwala R. A., Padinhare Purayil M., Shah S., Chawla K., Kothiwale V. A., Raghuraman B., Vijayaraghavan G., Vijan V. M., Bantwal G., Bisne V., Khan A., Gupta J. B., Kumar S., Jain D., Abraham S., Adak D., Barai A., Begum H., Bhattacharjee P., Dargude M., Davies D., Deshpande B., Dhakrao P., Dhyani V., Duhan S., Earath M., Ganatra A., Giradkar S., Jain V., Karthikeyan R., Kasala L., Kaur S., Krishnappa S., Lawande A., Lokesh B., Madarkar N., Meena R., More P., Naik D., Prashanth K., Rao M., Rao N. M., Sadhu N., Shah D., Sharma M., Shiva P., Singhal S., Suresh S., Vanajakshamma V., Panse S. G., Kanamori S., Yamamoto K., Kumagai K., Katsuda Y., Sadamatsu K., Toyota F., Mizuno Y., Misumi I., Noguchi H., Ando S., Suetsugu T., Minamoto M., Oda H., Shiraishi K., Adachi S., Chiba K., Norita H., Tsuruta M., Koyanagi T., Ando H., Higashi T., Okada K., Azakami S., Komaki S., Kumeda K., Murayama T., Matsumura J., Oba Y., Sonoda R., Goto K., Minoda K., Haraguchi Y., Suefuji H., Miyagi H., Kato H., Nakamura T., Nandate H., Zaitsu R., Fujiura Y., Yoshimura A., Numata H., Ogawa J., Tatematsu H., Kamogawa Y., Murakami K., Wakasa Y., Yamasawa M., Maekawa H., Abe S., Kihara H., Tsunoda S., Saito K., Fudo T., Obunai K., Tachibana H., Oba I., Kuwahata T., Higa S., Gushiken M., Eto T., Yoshida H., Ikeda D., Ishizawa M., Nakatsuka M., Murata K., Ogurusu C., Shimoyama M., Akutsu M., Takamura I., Hoshino F., Yokota N., Iwao T., Tsuchida K., Takeuchi M., Hatori Y., Kitami Y., Nakamura Y., Oyama R., Ageta M., Go Y., Mishima K., Unoki T., Morii S., Shiga Y., Sumi H., Nagatomo T., Sanno K., Fujisawa K., Atsuchi Y., Nagoshi T., Seto T., Tabuchi T., Kameko M., Nii K., Oshiro K., Takezawa H., Nagano S., Miyamoto N., Iwaki M., Fujii M., Okawa M., Abe M., Saito T., Mito T., Nagao K., Minami J., Mita T., Sakuma I., Taguchi T., Marusaki S., Doi H., Tanaka M., Fujito T., Matsuta M., Kusumoto T., Kakinoki S., Ashida K., Yoshizawa N., Agata J., Arasaki O., Manita M., Ikemura M., Fukuoka S., Murakami H., Matsukawa S., Hata Y., Taniguchi T., Ko T., Kubo H., Imamaki M., Akiyama M., Inagaki M., Odakura H., Ueda T., Katsube Y., Nakata A., Watanabe H., Techigawara M., Igarashi M., Taga K., Kimura T., Tomimoto S., Shibuya M., Nakano M., Ito K., Seo T., Hiramitsu S., Hosokawa H., Hoshiai M., Hibino M., Miyagawa K., Horie H., Sugishita N., Soma A., Neya K., Yoshida T., Mizuguchi M., Ishiguro M., Minagawa T., Wada M., Mukawa H., Okuda F., Nagasaka S., Abe Y., Adachi T., Akahane K., Amano T., Aoki K., Aoyama T., Arai H., Arima S., Arino T., Asano H., Asano T., Azuma J., Baba T., Betsuyaku T., Chibana H., Date H., Doiuchi J., Emura Y., Endo M., Fujii Y., Fujiki R., Fujisawa A., Fujisawa Y., Fukuda T., Fukui T., Furukawa N., Furukawa T., Furumoto W., Goto T., Hamaoka M., Hanazono N., Hasegawa K., Hatsuno T., Hayashi Y., Higuchi K., Hirasawa K., Hirayama H., Hirose M., Hirota S., Honda M., Ido T., Iiji O., Ikeda H., Ikeda K., Ikeoka K., Imaizumi M., Inaba H., Inoue T., Iseki F., Ishihara A., Ishioka N., Ito N., Iwase T., Kakuda H., Kamata J., Kanai H., Kanda H., Kaneko M., Kano H., Kasai T., Kato T., Kato Y., Kawada Y., Kawai K., Kawakami K., Kawakami S., Kawamoto T., Kawano S., Kim J., Kira T., Kitazawa H., Kitazumi H., Kito T., Kobayashi T., Koeda T., Kojima J., Komatsu H., Komatsu I., Koshibu Y., Kotani T., Kozuka T., Kumai Y., Kumazaki T., Maeda I., Maeda K., Maruyama Y., Matsui S., Matsushita K., Matsuura Y., Mineoi K., Mitsuhashi H., Miura N., Miyaguchi S., Miyajima S., Miyamoto H., Miyashita A., Miyata S., Mizuguchi I., Mizuno A., Mori T., Moriai O., Morishita K., Murai O., Nagai S., Nagata E., Nagata H., Nakagomi A., Nakahara S., Nakamura M., Nakamura R., Nakanishi N., Nakayama T., Nakazato R., Nanke T., Nariyama J., Niijima Y., Niinuma H., Nishida Y., Nishihata Y., Nishino K., Nishioka H., Nishizawa K., Niwa I., Nomura K., Nomura S., Nozoe M., Ogawa T., Ohara N., Okada M., Okamoto K., Okita H., Okuyama M., Ono H., Ono T., Pearce Y. O., Oriso S., Ota A., Otaki E., Saito Y., Sakai H., Sakamoto N., Sakamoto Y., Samejima Y., Sasagawa Y., Sasaguri H., Sasaki A., Sasaki T., Sato K., Sawano M., Seki S., Sekine Y., Seta Y., Sezaki K., Shibata N., Shiina Y., Shimono H., Shimoyama Y., Shindo T., Shinohara H., Shinohe R., Shinozuka T., Shirai T., Shiraiwa T., Shozawa Y., Suga T., Sugimoto C., Suzuki K., Suzuki S., Suzuki Y., Tada M., Taguchi A., Takagi T., Takagi Y., Takahashi K., Takahashi S., Takai H., Takanaka C., Take S., Takeda H., Takei K., Takenaka K., Tana T., Tanabe G., Taya K., Teragawa H., Tohyo S., Toru S., Tsuchiya Y., Tsuji T., Tsuzaki K., Uchiyama H., Ueda O., Ueyama Y., Wakaki N., Wakiyama T., Washizuka T., Watanabe M., Yamada T., Yamagishi T., Yamaguchi H., Yamamoto T., Yamaura M., Yamazoe M., Yasui K., Yokoyama Y., Yoshida K., Ching C. K., Foo C. G., Chow J. H., Chen D. D., Jaufeerally F. R., Lee Y. M., Lim G., Lim W. T., Thng S., Yap S. Y., Yeo C., Pak H. N., Kim J. -B., Kim J. H., Jang S. -W., Kim D. H., Ryu D. R., Park S. W., Kim D. -K., Choi D. J., Oh Y. S., Cho M. -C., Kim S. -H., Jeon H. -K., Shin D. -G., Park J. S., Park H. K., Han S. -J., Sung J. H., Cho J. -G., Nam G. -B., On Y. K., Lim H. E., Kwak J. J., Cha T. -J., Hong T. J., Park S. H., Yoon J. H., Kim N. -H., Kim K. -S., Jung B. C., Hwang G. -S., Kim C. -J., Kim D. B., Ahn J. J., An H. J., Bae H., Baek A. L., Chi W. J., Choi E. A., Choi E. H., Choi H. K., Choi H. S., Han S., Heo E. S., Her K. O., Hwang S. W., Jang E. M., Jang H. -S., Jang S., Jeon H. -G., Jeon S. R., Jeon Y. R., Jeong H. K., Jung I. -A., Kim H. J., Kim J. S., Kim J. A., Kim K. T., Kim M. S., Kim S. H., Kim Y. -I., Lee C. S., Lee E. H., Lee G. H., Lee H. Y., Lee H. -Y., Lee K. H., Lee K. R., Lee M. S., Lee M. -Y., Lee R. W., Lee S. E., Lee S. H., Lee S., Lee W. Y., Noh I. K., Park A. R., Park B. R., Park H. N., Park J. H., Park M., Park Y., Seo S. -Y., Shim J., Sim J. H., Sohn Y. M., Son W. S., Son Y. S., Song H. J., Wi H. K., Woo J. J., Ye S., Yim K. H., Yoo K. M., Yoon E. J., Yun S. Y., Chawanadelert S., Mongkolwongroj P., Kanokphatcharakun K., Cheewatanakornkul S., Laksomya T., Pattanaprichakul S., Chantrarat T., Rungaramsin S., Silaruks S., Wongcharoen W., Siriwattana K., Likittanasombat K., Katekangplu P., Boonyapisit W., Cholsaringkarl D., Chatlaong B., Chattranukulchai P., Santanakorn Y., Hutayanon P., Khunrong P., Bunyapipat T., Jai-Aue S., Kaewsuwanna P., Bamungpong P., Gunaparn S., Hongsuppinyo S., Inphontan R., Khattaroek R., Khunkong K., Kitmapawanont U., Kongsin C., Naratreekoon B., Ninwaranon S., Phangyota J., Phrommintikul A., Phunpinyosak P., Pongmorakot K., Poomiphol S., Pornnimitthum N., Pumprueg S., Ratchasikaew S., Sanit K., Sawanyawisuth K., Silaruks B., Sirichai R., Sriwichian A., Suebjaksing W., Sukklad P., Suttana T., Tangsirira A., Thangpet O., Tiyanon W., Vorasettakarnkij Y., Wisaratapong T., Wongtheptien W., Wutthimanop A., Yawila S., Altun A., Ozdogru I., Ozdemir K., Yilmaz O., Aydinlar A., Yilmaz M. B., Yeter E., Ongen Z., Cayli M., Pekdemir H., Ozdemir M., Sucu M., Sayin T., Demir M., Yorgun H., Ersanli M., Okuyan E., Aras D., Abdelrahman H., Aktas O., Alpay D., Aras F., Bireciklioglu M. F., Budeyri S., Buyukpapuc M., Caliskan S., Esen M., Felekoglu M. A., Genc D., Ikitimur B., Karaayvaz E. B., Karatas S. K., Okutucu S., Ozcelik E., Quisi A., Sag H., Sahiner L., Sayin B. Y., Seker T., Alkan D. U., Yildirim E., Yildirim R., Yilmaz F., Yuksekdag V., Vensentini N., Ingaramo A. C., Sambadaro G. A., Caputi V. F., Berman S. G., Dragotto P., Kleiban A. J., Centurion N., Giacomi G., Guerrero R. A. A., Conde D., Zapata G., Di Paola L. A., Ramos J. L., Dran R. D., Egido J., Fernandez A. A., Fosco M. J., Sassone S., Sinisi V. A., Cartasegna L. R., Berli M. A., Vilamajo O. A. G., Ferroni F., Alaguibe E. D., D'Amelio A. A., Arabetti C., Arias L., Belardi J. A., Bergesio L., Berli F., Berli M., Borchowiec S., Buzzetti C., Cabrini R., Campisi V., Cappi A. L., Carrizo R., Berra F. 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Registrie ,Male ,Latin Americans ,030204 cardiovascular system & hematology ,outcomes ,0302 clinical medicine ,Drug Prescription ,Retrospective Studie ,Risk Factors ,Atrial Fibrillation ,Antithrombotic ,Prospective Studies ,Registries ,030212 general & internal medicine ,Practice Patterns, Physicians' ,Stroke ,Anticoagulant ,Atrial fibrillation ,General Medicine ,Middle Aged ,Treatment Outcome ,Stroke prevention ,outcome ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,Human ,medicine.medical_specialty ,medicine.drug_class ,Clinical Investigations ,Hemorrhage ,antithrombotic treatment ,Drug Prescriptions ,03 medical and health sciences ,Internal medicine ,medicine ,Humans ,Mexico ,Aged ,Retrospective Studies ,Fibrillation ,business.industry ,Risk Factor ,Anticoagulants ,South America ,medicine.disease ,Drug Utilization ,Clinical trial ,Prospective Studie ,Latin American ,antithrombotic treatment, atrial fibrillation, Latin American, outcomes ,business - Abstract
Author(s): Jerjes-Sanchez, Carlos; Corbalan, Ramon; Barretto, Antonio CP; Luciardi, Hector L; Allu, Jagan; Illingworth, Laura; Pieper, Karen S; Kayani, Gloria; GARFIELD-AF Investigators | Abstract: BackgroundAtrial fibrillation (AF) is an important preventable cause of stroke. Anticoagulation (AC) therapy can reduce this risk. However, prescribing patterns and outcomes in patients with non-valvular AF (NVAF) from Latin American countries are poorly described.MethodsUsing data from the Global Anticoagulant Registry in the FIELD-AF (GARFIELD-AF), we examined the stroke prevention strategies and the 1-year outcomes in patients from four Latin American countries: Argentina, Brazil, Chile, and Mexico.ResultsA total of 4162 patients (2010-2014) were included in this analysis. At the time of AF diagnosis, 39.9% of patients were prescribed vitamin K antagonists (VKA) ± antiplatelet (AP) therapy, 21.8% non-VKA oral anticoagulant (NOAC) ± AP, 24.1% AP only and 14.1% no antithrombotic treatment. The proportion of moderate-high risk patients receiving no AC therapy at participating centers was highest in Mexico (46.4%) and lowest in Chile (14.3%). During 1-year follow-up, the rates of all-cause mortality, stroke/SE and major bleeding were: 5.77 (95% CI) (5.06-6.56), 1.58 (1.23-2.02), and 0.99 (0.72-1.36) and per 100 person-years, respectively, which are higher than the global rates across all countries in GARFIELD-AF. Unadjusted rates of all-cause mortality were highest in Argentina, 6.95 (5.43-8.90), and lowest in Chile, 4.01 (2.92-5.52).ConclusionsGARFIELD-AF results describes the marked variation in the baseline characteristics and patterns of antithrombotic treatments in patients with NVAF in four Latin American countries. Over one-third of patients with a moderate-to-high risk of stroke received no AC therapy, highlighting the need for improved management of patients according to national guideline. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362.
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- 2019
49. An Investigation of Dynamic Cerebral Autoregulation in Adolescent Concussion
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MOIR, M. ERIN, BALESTRINI, CHRISTOPHER S., ABBOTT, KOLTEN C., KLASSEN, STEPHEN A., FISCHER, LISA K., FRASER, DOUGLAS D., and SHOEMAKER, J. KEVIN
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- 2018
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50. Sex difference in the influence of central blood volume mobilization on the exercise pressor response
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Lalande, Sophie, Barron, Carly C., and Shoemaker, J. Kevin
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- 2015
- Full Text
- View/download PDF
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