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Narimalaheinan copper deposit is located in the east section of East Kunlun. Its ore forming belt belongs to Qimantage Dulan Variscan polymetallic metallogenic belt. The study of its tectonic activity provides scientific data for subsequent mineral exploration and the preservation and change of the deposit. Apatite fission track chronology method was used to explore the thermal chronological constraints of tectonic activities in different stages in the area, and the uplift rate and amount were quantitatively calculated. The ages of six apatite samples obtained in this study were (64±4), (59±3), (54±4), (57±4), (51±4), (57±4) Ma, P(χ2)＞5%, indicating a single thermal event reaction. The age of apatite samples is positively correlated with the elevation, indicating that the study area is uplifted as a whole by tectonic activities. The fission track length of apatite sample is (106±19)(123±17) μm. The track length is large, and the sample age value has a positive correlation with the track length, indicating that the older samples have a shorter residence time in the return zone and are less affected by later thermal events. The cooling curve simulation results show that the study area has experienced three stages of evolution: rapid uplift, stable uplift and rapid uplift, and the corresponding uplift amounts are 1 429, 285 and 1 571 m respectively. The thermal history in the area was simulated by HeFTy software, the results show that the thermal evolution in the region is divided into three stages. In the first stage (8065 Ma), the uplift rate is 0095 mm/a and the uplift amount is 1 429 m. There is a rapid uplift event, which records the beginning of the closure of the Yarlung Zangbo ocean and the beginning of the collision between India and Asia. In the second stage (6515 Ma) the uplift rate is 0006 mm/a and the uplift volume is 285 m, which occurrs slow uplift and records the collision event between the Indian plate and the Eurasian plate. In the third stage (15 Ma to now), the uplift rate is 0105 mm/a and the uplift volume is 1 571 m, which records the post collision between the Indian plate and the Eurasian plate, resulting in the rapid uplift of the study area at 15 Ma.

In order to explore the effect of Ti-Mo interdiffusion on metal hydrogen absorption, hydrogen absorption isotope effects at the TiMo alloy due to the interdiffusion at interface were investigated by using ion beam analysis (IBA) which is a nondestructive testing method. A Ti film of a few microns was deposited on a Mo substrate using a vacuum evaporation coating method, and interdiffusion layers appeared at the TiMo interface. The results indicate that there is a single gradient of elemental Ti or Mo concentration across the interdiffusion layer. Physical phase analyses show that Mo is substituted for Ti and exists as a solid solution. The effect of surface carbon (C) and oxygen (O) impurities on hydrogen (H) and deuterium (D) absorption was reduced by the argon ion sputtering thinning method. The presence of O below the detection limit and a small amount of C on the surface of the sample after sputter thinning have a minimal effect on hydrogen absorption. At the same time, the interdiffusion interface is brought closer to the surface. Hydrogen absorption experiments were carried out in an ultrahigh vacuum device. Both single and mixed absorption experiments for H2 and D2 were conducted, and the samples were analyzed by IBA. The results show that for the samples with clean surfaces, the distribution of hydrogen and deuterium in the solid phase decreases with the increase of molybdenum concentration after absorption of either hydrogen or deuterium gas. This is because that the presence of Mo reduces the bonding ability between the Ti atoms and interstitial H/D atoms, resulting in an increase in the equilibrium pressure of hydrogen/deuterium absorption and a decreased amount of hydrogen absorption. Moreover, the hydrogen concentration tends to decrease more slowly than the deuterium concentration with the increase of depth (i.e. the increase of Mo concentration). When Mo concentration in Ti is greater than 10%, the decrease in lattice constant leads to the reduction of lattice clearance volume. So hydrogen with smaller radius is more likely to occupy the volume gap position, resulting in a sharp drop in the content of largerradius deuterium atoms in the region with high Mo concentration. In mixed hydrogen absorption experiments, the pressure ratio of deuterium to hydrogen (p(H2)∶p(D2)) decreases with the increase of Mo content for p(H2)∶p(D2)≥05∶1, while for p(H2)∶p(D2)

AbstractThis study investigates the efficiency and influence of microneedle parameters, specifically Needle Point Angle (a) and Needle Height (h), on the diffusion of Cannabidiol (CBD) across varying skin depths. Utilizing the Latin Hypercube Sampling method, twelve distinct cases were analyzed. Observations reveal a consistent high concentration of CBD delivered via the microneedle patch, with a notable decrease in concentration as the depth increases, displaying a non-linear trend. Multivariate polynomial regression offers a quantitative relationship between the variables, with the third-order bivariate fitting providing the most accurate representation. Compared to other CBD delivery mechanisms, microneedle patches present enhanced CBD concentrations, circumventing challenges faced by other methods such as dosage inaccuracy, systemic absorption issues, and CBD degradation. The results highlight the potential of microneedle patches as a promising avenue for optimized transdermal drug delivery. [ABSTRACT FROM AUTHOR]