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Intravascular lymphomatosis (IVL) is a rare type of B-cell non-Hodgkin lymphoma (BCNHL), which can mimic many other diseases. Fever, neurological symptoms, and skin findings are the most frequent clinical findings. Intravascular lymphomatosis may be associated with genetic factors and infection with human immunodeficiency virus (HIV), human herpesvirus 8 (HHV-8), human T-lymphotropic virus 1 (HTLV1), Epstein-Barr virus (EBV), and hepatitis B virus (HBV). A 50-year-old man was hospitalized with recalcitrant hyponatremia of unknown cause. He had also telangiectatic, indurated, slightly erythematous plaques on his trunk for the last 10 days. His past medical history was unremarkable, although he was a carrier of hepatitis B. Multiple skin biopsies were performed and were considered to be diagnostic of IVL. The hyponatremia was unresponsive to water restriction and hypertonic solution support but it resolved with B cell directed chemotherapy. A final diagnosis was made as syndrome of inappropriate antidiuretic hormone (SIADH) in the setting of IVL. This case had a relatively early diagnosis with just 10-days of skin lesions. Intravascular lymphomatosis is a very rare disease and is usually difficult to diagnose. An even more uncommon presentation is IVL complicated by a paraneoplastic syndrome. There are prior reported cases of SIADH in the setting of IVL. However, this case underscores the importance of evaluating patients with SIADH for potential IVL.

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare, benign vascular tumor. Although its etiology is not clearly known, infection, hormonal factors, and trauma are the suspected reasons. There are few cases considered to be related to pregnancy described in the literature. Granulomas are rarely seen in the histopathology and only four patients with granulomas have been described. Herein, we will present a 28-year-old woman who has been pregnant three times; in every pregnancy, she developed pink nodular lesions on the back of her ear. In the first two pregnancies, the lesions had appeared during the pregnancy and regressed completely in the postpartum period. In her third pregnancy, the condition emerged again and lasted 1.5 years after birth of her child. Histopathology exhibited ALHE with granulomas. Although the relationship between ALHE and pregnancy is already known, there are few cutaneous ALHE cases associated with pregnancy reported in the literature. This association is further supported by this case having recurrent ALHE during each pregnancy period. Also, the presence of naked granuloma in histopathology, unlike most of the cases, contributes to the current histopathological data.

Background: It has been proven that there is an increase in intestinal permeability in some autoimmune diseases. In our study, we purposed to assess intestinal permeability in vitiligo disease by looking at zonulin levels. At the same time, we aimed to examine the correlation of inflammatory cytokines and lipopolysaccharide (LPS) levels with zonulin. Methods: Forty‐one patients and 41 healthy participants were involved in our study. Blood samples were taken from all patients and controls, and the levels of zonulin, tumor necrosis factor (TNF)‐α, interleukin (IL)‐6 and LPS were examined. Results: The mean of zonulin in the patient group was found to be statistically higher than the control group (p < 0.05). A positive correlation was found between zonulin level and IL‐6, TNF‐α, and LPS levels (p < 0.05). TNF‐α and LPS levels in the vitiligo group were significantly higher than in the control group, but there was no such significance in terms of IL‐6 levels. Conclusion: We think that serum zonulin level increases and intestinal permeability increases in vitiligo disease. [ABSTRACT FROM AUTHOR]

OBJECTIVE: Seborrheic dermatitis (SD) is a chronic, recurrent inflammatory skin disease characterized by clinically scaly patches. It is known that skin diseases with chronic inflammation are associated with comorbid conditions such as metabolic syndrome, obesity, cardiovascular diseases (CVD) and diabetes. In recent years, there are studies investigating the relationship of SD with metabolic syndrome, hypertension, obesity and nutritional factors. However, there is no study evaluating body composition parameters in SD patients. In the light of this information, it was aimed to evaluate the relationship between SD and body composition parameters. METHODS: The study was conducted on a total of 78 participants, including 39 SD patients over the age of 18 and 39 age- and gender-matched control patients, who applied to the University Faculty of Medicine Dermatology outpatient clinic. Body composition parameters were measured for each participant with the Tanita MC 580 Body Analyzer. In addition, SD area severity ındex (SDASI) was calculated in the SD patient group. These parameters were compared between the case and control groups. RESULTS: There was no significant difference concerning height (p=0.208), weight (p=0.309), body mass index (p=0.762), fat mass (p=0.092), metabolic age (p=0.916), body density (p=0.180), mineral (p=0.699), visceral adiposity (p=0.401), protein (p=0.665), and other body composition parameters, between the case and control groups. There was only positive correlation between SDASI and height (p=0.026) and protein (0.016) value. CONCLUSION: SD may be associated with obesity, metabolic syndrome, insulin resistance, and CVD, but the results are unclear and further studies are needed. [ABSTRACT FROM AUTHOR]

Androgenetic alopecia (AGA) is a progressive hair loss disease that occurs with the effect of androgens and genetic predisposition. Hair thinning and hair loss affect people's self‐confidence and self‐image more than is thought. In these patients, platelet rich plasma (PRP) treatment is used in addition to the limited medical treatments available. However, there is a lack of standardization for the application method of PRP treatment in the literature. The number of studies in which objective data and hair analysis parameters were revealed to demonstrate the effectiveness of PRP treatment is also very limited. In this study, it was aimed to show the efficacy of PRP treatment with trichoscan data in AGA patients and to compare dermapen‐mediated microneedling and point‐by‐point technique injection application methods. The study was conducted with 62 male AGA patients, aged between 18 and 55 years, who applied to the University Faculty of Medicine, Department of Dermatology, and ranged from Norwood‐Hamilton Stage II–V. The patients were randomly divided into two groups and one group was given microneedling with a dermapen, an electrical device that makes automatic needling, and the other group was given manual injection with point‐by‐point technique with a 30‐gauge needle. Before the first treatment, each patient underwent a trichoscan hair analysis evaluation. A total of four sessions of PRP treatment were performed, as three sessions at 2‐week intervals and the fourth session 1 month after the last session. The mean age of the cases was 33.13 ± 6.36. According to Norwood‐Hamilton staging, stage III was detected with the highest rate of 46% (29). Hair pulling test became significantly negative after treatment (p < 0.05). Statistically significant differences were found in trichoscan analysis parameters for hair count, hair density, terminal hair count, and terminal hair density in both groups compared to pretreatment (p < 0.05). Between the groups, a statistically significant difference was found between the averages of anagen hair, telogen hair, and hair length in the dermapen treated group compared to the group treated with the point‐by‐point technique. In our study, the efficacy of PRP treatment for AGA patients was demonstrated by trichoscan parameters. Among the PRP application methods, dermapen‐mediated application was found to be superior to the point‐by‐point technique in terms of anagen, telogen, and average hair length parameters. [ABSTRACT FROM AUTHOR]

However, lower doses with more modern laser devices have allowed laser therapy to be applied during or shortly after isotretinoin therapy.5 A 23-year-old female patient was using oral isotretinoin at a dose of 40 mg/day for acne treatment, and laser treatment was started for acne scars in the sixth month of treatment. It is thought that factors such as abnormal follicular keratinization, cutibacterium acnes colonization, and sebum production play a role in its pathogenesis.1 Post-acne erythema is defined as lesions consisting of telangiectatic and erythematous macules resulting from skin inflammation.2 Although there are literature data on the use of various lasers in the treatment of post-acne erythema, the results are variable.3,4 Laser procedures for acne and acne scars are traditionally performed at least six to eight months after the end of systemic isotretinoin therapy. Treatment of post-acne erythema with 585 nm Q-Switched Nd:YAG laser in a patient receiving isotretinoin therapy. [Extracted from the article]

ACC is divided into nine subgroups by Frieden and includes Bart syndrome, also known as type 6, aplasia cutis localized to the extremities, epidermolysis bullosa, and nail anomalies.2 The diagnosis is made clinically, and sometimes, it is supported histopathologically and genetically. Keywords: aplasia cutis congenital; Bart syndrome; mechanobullous disorder EN aplasia cutis congenital Bart syndrome mechanobullous disorder 3603 3605 3 08/09/22 20220801 NES 220801 CONFLICT OF INTEREST None to declare. Bart syndrome is a rare disease that should be considered in patients with ACC and bullous lesions. [Extracted from the article]

Aim: In this study, we compared the current diagnoses of patients admitted to the dermatology outpatient clinic with the diagnoses during the non‐pandemic period, and we examined the effect of COVID‐19 on the patient profile. Methods: Diagnoses were compared by examining the patient files of the 3‐month period when the pandemic was influential in our country and the 2‐week non‐pandemic period corresponding to the same season a year ago. The outpatient diagnoses in the first month and the last month of the 3‐month pandemic period were also compared. Results: During the 3‐month pandemic process, the most common reasons for applying to the outpatient clinic were acne, urticaria, psoriasis, and allergic/irritant contact dermatitis. Urticaria, psoriasis, allergic/irritant contact dermatitis, scabies, liken planus, mycosis fungoides, zona zoster, recurrent aphthous stomatitis and polymorph light eruption were statistically more common in the pandemic period. Moreover, acne, other eczematous dermatities, verruca, androgenic alopecia, and melanocytic nevus diagnoses were found to decrease statistically during the pandemic period when compared with the non‐pandemic period. Conclusion: Unlike other studies, the present study evaluated the patient diagnoses during the pandemic period and the period a year before and discussed the possible reasons for the changes in patient profiles. [ABSTRACT FROM AUTHOR]

Background/Aim: Androgenetic alopecia (AGA) is the most common type of hair loss. Androgens and genetic factors are responsible for pathogenesis. Blood groups are genetic markers that are used to identify human gene variation. The aim of this study was to evaluate the blood group distribution in patients with AGA and to compare it with healthy population. Materials and Methods: A total of 207 patients diagnosed with AGA in dermatology clinic and whose blood group records were available, between 2010 and 2019, were included in the study. Six hundred forty two healthy individuals who matched with the patient group in terms of age and sex, who attending to the family medicine outpatient clinic of our hospital in order to learn their blood groups were included as the control group. Results: When the results were compared, no statistically significant difference was found between the two groups (P ˃.05). Conclusion: We could not find any relationship between AGA and blood groups. However, in order to determine this relationship more clearly, further multicentre studies including more cases and investigating subgroups of the cases are needed. [ABSTRACT FROM AUTHOR]

Background: Adenosine deaminase (ADA) is an aminohydrolase involved in the catabolism of purine nucleotides and irreversibly deaminizes adenosine and deoxyadenosine to inosine and deoxyinosine. ADA enzyme deficiency results in the loss of functional properties of B and T lymphocytes. Demodex species have been reported to be transmitted between humans through close contact and to play a role in the pathogenesis of rosacea, acne vulgaris, perioral dermatitis, seborrhoeic dermatitis, micropapillary- pruritic dermatitis and blepharitis. The present study aimed to compare serum ADA levels in D. folliculorum positive patients with the healthy control individuals. Methods: Serum ADA levels were examined for 30 patients diagnosed with erythematotelangiectatic rosacea and 40 healthy individuals in Malatya Inonu University in 2017. Standardized skin surface biopsy (SSSB) method was used to diagnose D. folliculorum. A significant decrease was found in the ADA levels of Demodex-positive rosacea patients when compared to the control group. Results: ADA levels were decreased in the Demodex-positive group. The mean ADA level in patient group was significantly lower than the mean in the control group (P<0.001). There was no significant difference between the patient and control groups in terms of age and gender. Conclusion: During and after treatment of Demodex-positive rosacea patients, determination of ADA levels may give more detailed information on the immune mechanisms. [ABSTRACT FROM AUTHOR]

Background: Rosacea is a chronic inflammatory disease. Although the etiopathogenesis of the disease has not been established, it is known that inflammation plays a prominent role in the disease. Demodex mites have been thought to have a role in the pathogenesis of rosacea by causing the occurrence of inflammatory lesions. In the literature, many studies have reported that complete blood count (CBC) parameters have been used as diagnostic biomarkers in diseases associated with inflammatory process. Aims: The aim of this study was to evaluate CBC parameters in rosaceous patients with and without demodex mite and to compare with healthy controls (HCs). Patients/Methods: Ninety patients followed in our clinic between January and October 2019 and 62 healthy controls matching in terms of age and sex were included in the study. CBC parameters of the patients and the HCs were compared, retrospectively. Results: There was no statistically significant difference in mean platelet volume (MPV), red cell distribution width (RDW), neutrophil lymphocyte ratio, monocyte lymphocyte ratio, and platelet lymphocyte ratio levels between all patients and HCs. RDW values were significantly lower in demodex (+) rosace group, when compared to demodex (−) rosace group and HCs. Conclusions: The lower RDW levels in the demodex (+) group suggested that demodex mite did not have an increasing effect on inflammation and was effective in the disease through alternative pathways. [ABSTRACT FROM AUTHOR]

Aim: Using an appropriate sunscreen is very important because the role of sun rays in development of skin cancer is well known. Besides, the recent increase in the use of cosmetics among adolescents is noteworthy. In this study, we aimed to determine the frequency of using cosmetics and the level of awareness of harmful effects of the sun, in adolescents. Material and Methods: In this cross-sectional descriptive study, a questionnaire consisted of 25 questions was applied, on voluntary basis, in middle schools. Results: A total of 607 students participated in the study; 434 participants were female students (71.5%), 173 were male students (28.5%) and the average age was 17 years. The question "Do you think it is necessary to protect from the sun?" is answered as "yes" by 361 of the female students (81.1%) and 109 of the male students (62.3%). The question "Do you use sunscreen?" is answered as "Yes" by 33.3% of all participants. Conclusion: In our study, we found that adolescents had a good understanding of the harmful effects of sun, but in contrast to this, we found that the use of sunscreen products was at very low levels. We think that education and methods for building awareness in this regard will be effective. [ABSTRACT FROM AUTHOR]

Vitiligo is a pigment disease characterized by the disruption of melanocyte structure and function. Its etiology is unknown; however, genetic predisposition, biochemical factors, and neural mechanisms are thought to be effective. Although many agents are being used for its treatment, generally there is no absolute cure. The aim of the present study is to evaluate the effectiveness of topical Nigella sativa seed oil on vitiligo patients. Thirty‐three vitiligo patients were included in the study. Totally 47 areas were evaluated in all patients. Cream containing N sativa seed oil was topically applied to hands, face, and genital region two times a day for 6 months. Statistically significant repigmentation was detected in hands, face, and genital region, the three treatment areas, and the p values are found.005,.001, and.004, respectively. N sativa can be used as an adjuvant therapy that can contribute to the treatment especially in sensitive skin areas like genital region. [ABSTRACT FROM AUTHOR]

Introduction: Teledermatology represents an alternative medical approach allowing for the remote assessment of a patient's clinical information without the need for face-to-face consultations., Objectives: This study aims to gauge the public's awareness and perception of teledermatology., Methods: This research employed a cross-sectional observational design. Data collection was executed using an online survey. Sociodemographic attributes of all participants, such as age, gender, and occupation, were recorded. The survey, designed using Google Forms, comprised two sections: demographic information (5 questions) and queries related to teledermatology (10 questions). Questions and options in the survey were reviewed and revised by two dermatologists to eliminate potential misunderstandings, grammar, and other errors. Power analysis indicated a requirement of a minimum of 527 participants, given a 0.05 margin of error, 98% confidence level, and 0.50 response distribution., Results: A total of 873 individuals completed the survey- 47.7% were male and 52.3% were female. Students made up 48.1% of the participants, while 22.6% were civil servants. The Marmara Region had the highest participation rate at 47.7%. Remarkably, 41.9% of participants were unfamiliar with the term "teledermatology". However, 57.2% expressed a preference for consultations via teledermatology. Furthermore, 63.7% mentioned facing challenges when attempting to communicate with dermatologists for skin-related concerns. A notable 71.6% supported the formal implementation of teledermatology in our country., Conclusions: Our survey highlighted a limited awareness of teledermatology among participants, yet a majority showed a preference for teledermatology consultations. For a comprehensive understanding of public knowledge and perception towards teledermatology, more extensive, multicentric studies are necessary.

The skin disease of the pilosebaceous unit created by demodex mites is called demodicosis. Recently, it has been brought to the agenda that laser therapies can be effective in reducing the intensity of demodex parasite. With this study, we aimed to evaluate the effect of pro-yellow laser applied to the face on the intensity of demodex parasite. Twenty-five patients who had referred to the dermatology polyclinic with a complaint of rash on the face and who had been given proyellow laser therapy during the past year were included in the study. Average pre-laser therapy demodex number per cm 2 was 3.9 ± 5.0, while average post-therapy demodex number per cm 2 was 2.6 ± 4.9 (p = .117). The 577-nm pro-yellow laser caused a change in demodex density. We found that the number of demodex following laser therapy decreased in some patients, while it increased in some others.