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The commensal microflora provides a repertoire of antigens that illicit mucosal antibodies. In some cases, these antibodies can cross-react with host proteins, inducing autoimmunity, or with other microbial antigens. We demonstrate that the oral microbiota can induce salivary anti-SARS-CoV-2 Spike IgG antibodies via molecular mimicry. Anti-Spike IgG antibodies in the saliva correlated with enhanced abundance of Streptococcus salivarius 1 month after anti-SARS-CoV-2 vaccination. Several human commensal bacteria, including S. salivarius, were recognized by SARS-CoV-2-neutralizing monoclonal antibodies and induced cross-reactive anti-Spike antibodies in mice, facilitating SARS-CoV-2 clearance. A specific S. salivarius protein, RSSL-01370, contains regions with homology to the Spike receptor-binding domain, and immunization of mice with RSSL-01370 elicited anti-Spike IgG antibodies in the serum. Additionally, oral S. salivarius supplementation enhanced salivary anti-Spike antibodies in vaccinated individuals. Altogether, these data show that distinct species of the human microbiota can express molecular mimics of SARS-CoV-2 Spike protein, potentially enhancing protective immunity., Competing Interests: Declaration of interests Related to this work, Deutsches Rheuma-Forschungszentrum (DRFZ) has filed a patent application., (Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)

Purpose : There is no significant evidence of both biological and motivational effects between virtual reality exercises to traditional/conventional exercise. The aim of this study is to assess the biological and motivational effects of aerobic exercises with virtual reality and traditional exercise methods. Methods : 20 students participated as control and 60 students were divided randomly and equally into two groups, virtual reality exercise group (VRE) and traditional exercise group (TE). Two groups completed the exercise training. Tests were applied to the three groups at the beginning and in the end of the study. An activity monitor and pulse oximeter were used to measure energy expenditure during exercises. Results : After eight weeks, the data from pulse oximeter showed no statistical significance between the exercise groups. The active energy expenditure, PAL and step counts were statistically significant in TE group. There was a statistically significant increase in the sleep quality of the TE group ( p = .000). There was no statistical significance among the anxiety scores of all groups. In the spring semester, there was a statistically significant increase in both VRE and TE groups compared to the fall semester ( p < .05). Conclusion : The virtual reality exercises produce greater motivational effects, whereas traditional exercises bring greater physical improvements.

The intestinal tract is densely populated by microbiota consisting of various commensal microorganisms that are instrumental for the healthy state of the living organism. Such commensals generate various molecules that can be recognized by the Toll-like receptors of the immune system leading to the inflammation marked by strong upregulation of various proinflammatory cytokines, such as TNF, IL-6, and IL-1β. To prevent excessive inflammation, a single layer of constantly renewing, highly proliferating epithelial cells (IEC) provides proper segregation of such microorganisms from the body cavities. There are various triggers which facilitate the disturbance of the epithelial barrier which often leads to inflammation. However, the nature and duration of the stress may determine the state of the epithelial cells and their responses to cytokines. Here we discuss the role of the microbiota-TLR-cytokine axis in the maintenance of the epithelial tissue integrity. In particular, we highlight discrepancies in the function of TLR and cytokines in IEC barrier during acute or chronic inflammation and we suggest that intervention strategies should be applied based on the type of inflammation., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Semin, Ninnemann, Bondareva, Gimaev and Kruglov.)