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1. Axial slicing versus bivalving in the pathological examination of pancreatoduodenectomy specimens (APOLLO): a multicentre randomized controlled trial

Author

van Roessel, Stijn, Soer, Eline C., van Dieren, Susan, Koens, Lianne, van Velthuysen, Marie Louise F., Doukas, Michael, Groot Koerkamp, Bas, Fariña Sarasqueta, Arantza, Bronkhorst, Carolien M., Raicu, G. Mihaela, Kuijpers, Karel C., Seldenrijk, Cornelis A., van Santvoort, Hjalmar C., Molenaar, I. Quintus, van der Post, Rachel S., Stommel, Martijn W.J., Busch, Olivier R., Besselink, Marc G., Brosens, Lodewijk A.A., and Verheij, Joanne

Published
2021
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2. Associations of non-pedunculated T1 colorectal adenocarcinoma outcome with consensus molecular subtypes, immunoscore, and microsatellite status: a multicenter case-cohort study

Author

Haasnoot, Krijn J.C., Backes, Yara, Moons, Leon M.G., Kranenburg, Onno, Trinh, Anne, Vermeulen, Louis, Noë, Michaël, Tuynman, Jurriaan B., van Lent, Anja U.G., van Ginneken, Rosaline, Seldenrijk, Cornelis A., Raicu, Mihaela G., Trumpi, Kari, Ubink, Inge, Milne, Anya N., Boonstra, Jurjen J., Groen, John N., Schwartz, Matthijs P., Wolfhagen, Frank H.J., Geesing, Joost M.J., ter Borg, Frank, Brosens, Lodewijk A.A., van Bergeijk, Jeroen, Spanier, Bernhard W.M., de Vos tot Nederveen Cappel, Wouter H., Kessels, Koen, Seerden, Tom C.J., Vleggaar, Frank P., Offerhaus, G. Johan A., Siersema, Peter D., Elias, Sjoerd G., and Laclé, Miangela M.

Published
2020
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3. Histologic Factors Associated With Need for Surgery in Patients With Pedunculated T1 Colorectal Carcinomas

Author

Backes, Yara, Elias, Sjoerd G., Groen, John N., Schwartz, Matthijs P., Wolfhagen, Frank H.J., Geesing, Joost M.J., ter Borg, Frank, van Bergeijk, Jeroen, Spanier, Bernhard W.M., de Vos tot Nederveen Cappel, Wouter H., Kessels, Koen, Seldenrijk, Cornelis A., Raicu, Mihaela G., Drillenburg, Paul, Milne, Anya N., Kerkhof, Marjon, Seerden, Tom C.J., Siersema, Peter D., Vleggaar, Frank P., Offerhaus, G. Johan A., Lacle, Miangela M., and Moons, Leon M.G.

Published
2018
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4. Multicentre evaluation of multidisciplinary team meeting agreement on diagnosis in diffuse parenchymal lung disease: a case-cohort study

Author

Walsh, Simon L F, Wells, Athol U, Desai, Sujal R, Poletti, Venerino, Piciucchi, Sara, Dubini, Alessandra, Nunes, Hilario, Valeyre, Dominique, Brillet, Pierre Y, Kambouchner, Marianne, Morais, António, Pereira, José M, Moura, Conceição Souto, Grutters, Jan C, van den Heuvel, Daniel A, van Es, Hendrik W, van Oosterhout, Matthijs F, Seldenrijk, Cornelis A, Bendstrup, Elisabeth, Rasmussen, Finn, Madsen, Line B, Gooptu, Bibek, Pomplun, Sabine, Taniguchi, Hiroyuki, Fukuoka, Junya, Johkoh, Takeshi, Nicholson, Andrew G, Sayer, Charlie, Edmunds, Lilian, Jacob, Joseph, Kokosi, Maria A, Myers, Jeffrey L, Flaherty, Kevin R, and Hansell, David M

Published
2016
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6. 43 TISSUECYPHER OBJECTIVELY RISK STRATIFIES BARRETT'S ESOPHAGUS PATIENTS WITH LOW GRADE DYSPLASIA

Author

Frei, Nicola, primary, Khoshiwal, Amir M., additional, Konte, Kadere, additional, Pouw, Roos E., additional, Kate, Fiebo Ten, additional, Seldenrijk, Cornelis A., additional, Offerhaus, Johan, additional, Goldblum, John R., additional, Davison, Jon M., additional, Bossart, Emily A., additional, Critchley-Thorne, Rebecca J., additional, and Bergman, Jacques, additional

Published
2021
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7. Axial slicing versus bivalving in the pathological examination of pancreatoduodenectomy specimens (APOLLO):a multicentre randomized controlled trial

Author

van Roessel, Stijn, Soer, Eline C., van Dieren, Susan, Koens, Lianne, van Velthuysen, Marie Louise F., Doukas, Michael, Groot Koerkamp, Bas, Fariña Sarasqueta, Arantza, Bronkhorst, Carolien M., Raicu, G. Mihaela, Kuijpers, Karel C., Seldenrijk, Cornelis A., van Santvoort, Hjalmar C., Molenaar, I. Quintus, van der Post, Rachel S., Stommel, Martijn W.J., Busch, Olivier R., Besselink, Marc G., Brosens, Lodewijk A.A., Verheij, Joanne, van Roessel, Stijn, Soer, Eline C., van Dieren, Susan, Koens, Lianne, van Velthuysen, Marie Louise F., Doukas, Michael, Groot Koerkamp, Bas, Fariña Sarasqueta, Arantza, Bronkhorst, Carolien M., Raicu, G. Mihaela, Kuijpers, Karel C., Seldenrijk, Cornelis A., van Santvoort, Hjalmar C., Molenaar, I. Quintus, van der Post, Rachel S., Stommel, Martijn W.J., Busch, Olivier R., Besselink, Marc G., Brosens, Lodewijk A.A., and Verheij, Joanne

Abstract

Background: In pancreatoduodenectomy specimens, dissection method may affect the assessment of primary tumour origin (i.e. pancreatic, distal bile duct or ampullary adenocarcinoma), which is primarily determined macroscopically. This is the first study to prospectively compare the two commonly used techniques, i.e. axial slicing and bivalving. Methods: In four centres, a randomized controlled trial was performed in specimens of patients with a suspected (pre)malignant tumour in the pancreatic head. Primary outcome measure was the level of certainty (scale 0–100) regarding tumour origin by four independent gastrointestinal pathologists based on macroscopic assessment. Secondary outcomes were inter-observer agreement and R1 rate. Results: In total, 128 pancreatoduodenectomy specimens were randomized. The level of certainty in determining the primary tumour origin did not differ between axial slicing and bivalving (mean score 72 [sd 13] vs. 68 [sd 16], p = 0.21), nor did inter-observer agreement, both being moderate (kappa 0.45 vs. 0.47). In pancreatic cancer specimens, R1 rate (60% vs. 55%, p = 0.71) and the number of harvested lymph nodes (median 16 vs. 17, p = 0.58) were similar. Conclusion: This study demonstrated no differences in determining the tumour origin between axial slicing and bivalving. Both techniques performed similarly regarding inter-observer agreement, R1 rate, and lymph node harvest.

Published
2021

8. First-line palliative systemic therapy alternated with electrostatic pressurised intraperitoneal aerosol chemotherapy (oxaliplatin) for isolated unresectable colorectal peritoneal metastases: Protocol of a multicentre, single-arm, phase II study (CRC-PIPAC-II)

Author

Research UMC Utrecht, Lab Translational Oncology, Cancer, Regenerative Medicine and Stem Cells, Lurvink, Robin J., Rauwerdink, Paulien, Rovers, Koen P., Wassenaar, Emma C.E., Deenen, Maarten J., Nederend, Joost, Huysentruyt, Clément J.R., Van 'T Erve, Iris, Fijneman, Remond J.A., Van Der Hoeven, Erik J.R.J., Seldenrijk, Cornelis A., Constantinides, Alexander, Kranenburg, Onno, Los, Maartje, Herbschleb, Karin H., Thijs, Anna M.J., Creemers, Geert Jan M., Burger, Jacobus W.A., Wiezer, Marinus J., Nienhuijs, Simon W., Boerma, Djamila, De Hingh, Ignace H.J.T., Research UMC Utrecht, Lab Translational Oncology, Cancer, Regenerative Medicine and Stem Cells, Lurvink, Robin J., Rauwerdink, Paulien, Rovers, Koen P., Wassenaar, Emma C.E., Deenen, Maarten J., Nederend, Joost, Huysentruyt, Clément J.R., Van 'T Erve, Iris, Fijneman, Remond J.A., Van Der Hoeven, Erik J.R.J., Seldenrijk, Cornelis A., Constantinides, Alexander, Kranenburg, Onno, Los, Maartje, Herbschleb, Karin H., Thijs, Anna M.J., Creemers, Geert Jan M., Burger, Jacobus W.A., Wiezer, Marinus J., Nienhuijs, Simon W., Boerma, Djamila, and De Hingh, Ignace H.J.T.

Published
2021

9. Axial slicing versus bivalving in the pathological examination of pancreatoduodenectomy specimens (APOLLO): a multicentre randomized controlled trial

Author

MS HOD, Cancer, MS CGO, Pathologie Pathologen staf, van Roessel, Stijn, Soer, Eline C., van Dieren, Susan, Koens, Lianne, van Velthuysen, Marie Louise F., Doukas, Michael, Koerkamp, Bas Groot, Sarasqueta, Arantza Farina, Bronkhorst, Carolien M., Raicu, G. Mihaela, Kuijpers, Karel C., Seldenrijk, Cornelis A., van Santvoort, Hjalmar C., Molenaar, I. Quintus, van der Post, Rachel S., Stommel, Martijn W. J., Busch, Olivier R., Besselink, Marc G., Brosens, Lodewijk A. A., Verheij, Joanne, MS HOD, Cancer, MS CGO, Pathologie Pathologen staf, van Roessel, Stijn, Soer, Eline C., van Dieren, Susan, Koens, Lianne, van Velthuysen, Marie Louise F., Doukas, Michael, Koerkamp, Bas Groot, Sarasqueta, Arantza Farina, Bronkhorst, Carolien M., Raicu, G. Mihaela, Kuijpers, Karel C., Seldenrijk, Cornelis A., van Santvoort, Hjalmar C., Molenaar, I. Quintus, van der Post, Rachel S., Stommel, Martijn W. J., Busch, Olivier R., Besselink, Marc G., Brosens, Lodewijk A. A., and Verheij, Joanne

Published
2021

10. First-line palliative systemic therapy alternated with electrostatic pressurised intraperitoneal aerosol chemotherapy (oxaliplatin) for isolated unresectable colorectal peritoneal metastases: protocol of a multicentre, single-arm, phase II study (CRC-PIPAC-II)

Author

Lurvink, Robin J., primary, Rauwerdink, Paulien, additional, Rovers, Koen P., additional, Wassenaar, Emma C.E., additional, Deenen, Maarten J., additional, Nederend, Joost, additional, Huysentruyt, Clément J.R., additional, van 't Erve, Iris, additional, Fijneman, Remond J.A., additional, van der Hoeven, Erik J.R.J., additional, Seldenrijk, Cornelis A., additional, Constantinides, Alexander, additional, Kranenburg, Onno, additional, Los, Maartje, additional, Herbschleb, Karin H., additional, Thijs, Anna M.J., additional, Creemers, Geert-Jan M., additional, Burger, Jacobus W.A., additional, Wiezer, Marinus J., additional, Nienhuijs, Simon W., additional, Boerma, Djamila, additional, and de Hingh, Ignace H.J.T., additional

Published
2021
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11. sj-pdf-1-ueg-10.1177_2050640620975324 - Supplemental material for Tumour–stroma ratio has poor prognostic value in non-pedunculated T1 colorectal cancer: A multi-centre case-cohort study

Author

Dang, Hao, Pelt, Gabi W Van, Haasnoot, Krijn JC, Backes, Yara, Elias, Sjoerd G, Seerden, Tom CJ, Schwartz, Matthijs P, Spanier, Bernhard WM, Cappel, Wouter H De Vos Tot Nederveen, Bergeijk, Jeroen D Van, Kessels, Koen, Geesing, Joost MJ, Groen, John N, Borg, Frank Ter, Wolfhagen, Frank HJ, Seldenrijk, Cornelis A, Raicu, Mihaela G, Milne, Anya N, Lent, Anja UG Van, Brosens, Lodewijk AA, G Johan A Offerhaus, Siersema, Peter D, Tollenaar, Rob AEM, Hardwick, James CH, Hawinkels, Lukas JAC, Moons, Leon MG, Miangela M Lacle, Mesker, Wilma E, and Boonstra, Jurjen J

Subjects
FOS: Clinical medicine, FOS: Biological sciences, 111199 Nutrition and Dietetics not elsewhere classified, FOS: Health sciences, 110308 Geriatrics and Gerontology, 69999 Biological Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, sj-pdf-1-ueg-10.1177_2050640620975324 for Tumour–stroma ratio has poor prognostic value in non-pedunculated T1 colorectal cancer: A multi-centre case-cohort study by Hao Dang, Gabi W van Pelt, Krijn JC Haasnoot, Yara Backes, Sjoerd G Elias, Tom CJ Seerden, Matthijs P Schwartz, Bernhard WM Spanier, Wouter H de Vos tot Nederveen Cappel, Jeroen D van Bergeijk, Koen Kessels, Joost MJ Geesing, John N Groen, Frank ter Borg, Frank HJ Wolfhagen, Cornelis A Seldenrijk, Mihaela G Raicu, Anya N Milne, Anja UG van Lent, Lodewijk AA Brosens, G Johan A Offerhaus, Peter D Siersema, Rob AEM Tollenaar, James CH Hardwick, Lukas JAC Hawinkels, Leon MG Moons, Miangela M Lacle, Wilma E Mesker, Jurjen J Boonstra and on behalf of the Dutch T1 CRC Working Group in United European Gastroenterology Journal

Published
2020
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12. Associations of non-pedunculated T1 colorectal adenocarcinoma outcome with consensus molecular subtypes, immunoscore, and microsatellite status: a multicenter case-cohort study

Author

MS MDL 1, Cancer, Unit Opleiding MDL, Unit Opleiding Aios, Lab Translational Oncology, Regenerative Medicine and Stem Cells, CMM Groep Coffer, MS CGO, Heelkunde Opleiding, Pathologie Pathologen staf, Epi Kanker Team A, JC onderzoeksprogramma Kanker, Haasnoot, Krijn J.C., Backes, Yara, Moons, Leon M.G., Kranenburg, Onno, Trinh, Anne, Vermeulen, Louis, Noë, Michaël, Tuynman, Jurriaan B., van Lent, Anja U.G., van Ginneken, Rosaline, Seldenrijk, Cornelis A., Raicu, Mihaela G., Trumpi, Kari, Ubink, Inge, Milne, Anya N., Boonstra, Jurjen J., Groen, John N., Schwartz, Matthijs P., Wolfhagen, Frank H.J., Geesing, Joost M.J., ter Borg, Frank, Brosens, Lodewijk A.A., van Bergeijk, Jeroen, Spanier, Bernhard W.M., de Vos tot Nederveen Cappel, Wouter H., Kessels, Koen, Seerden, Tom C.J., Vleggaar, Frank P., Offerhaus, G. Johan A., Siersema, Peter D., Elias, Sjoerd G., Laclé, Miangela M., on behalf of the Dutch T1 CRC Working Group, MS MDL 1, Cancer, Unit Opleiding MDL, Unit Opleiding Aios, Lab Translational Oncology, Regenerative Medicine and Stem Cells, CMM Groep Coffer, MS CGO, Heelkunde Opleiding, Pathologie Pathologen staf, Epi Kanker Team A, JC onderzoeksprogramma Kanker, Haasnoot, Krijn J.C., Backes, Yara, Moons, Leon M.G., Kranenburg, Onno, Trinh, Anne, Vermeulen, Louis, Noë, Michaël, Tuynman, Jurriaan B., van Lent, Anja U.G., van Ginneken, Rosaline, Seldenrijk, Cornelis A., Raicu, Mihaela G., Trumpi, Kari, Ubink, Inge, Milne, Anya N., Boonstra, Jurjen J., Groen, John N., Schwartz, Matthijs P., Wolfhagen, Frank H.J., Geesing, Joost M.J., ter Borg, Frank, Brosens, Lodewijk A.A., van Bergeijk, Jeroen, Spanier, Bernhard W.M., de Vos tot Nederveen Cappel, Wouter H., Kessels, Koen, Seerden, Tom C.J., Vleggaar, Frank P., Offerhaus, G. Johan A., Siersema, Peter D., Elias, Sjoerd G., Laclé, Miangela M., and on behalf of the Dutch T1 CRC Working Group

Published
2020

13. Improved diagnostic stratification of digitised Barrett's oesophagus biopsies by p53 immunohistochemical staining

Author

van der Wel, Myrtle J., Duits, Lucas C., Pouw, Roos E., Seldenrijk, Cornelis A., Offerhaus, G. J.A., Visser, Mike, ten Kate, Fiebo J., Biermann, Katharina, Brosens, Lodewijk A.A., Doukas, Michael, Huysentruyt, Clement, Karrenbeld, Arend, Kats-Ugurlu, Gursah, van der Laan, Jaap S., van Lijnschoten, G. Ineke, Moll, Freek C.P., Ooms, Ariadne H.A.G., van der Valk, Hans, Tijssen, Jan G., Bergman, Jacques J., Meijer, Sybren L., van der Wel, Myrtle J., Duits, Lucas C., Pouw, Roos E., Seldenrijk, Cornelis A., Offerhaus, G. J.A., Visser, Mike, ten Kate, Fiebo J., Biermann, Katharina, Brosens, Lodewijk A.A., Doukas, Michael, Huysentruyt, Clement, Karrenbeld, Arend, Kats-Ugurlu, Gursah, van der Laan, Jaap S., van Lijnschoten, G. Ineke, Moll, Freek C.P., Ooms, Ariadne H.A.G., van der Valk, Hans, Tijssen, Jan G., Bergman, Jacques J., and Meijer, Sybren L.

Published
2018

14. Histologic Factors Associated With Need for Surgery in Patients With Pedunculated T1 Colorectal Carcinomas

Author

MS MDL 1, Cancer, Epi Kanker Team A, JC onderzoeksprogramma Kanker, MS CGO, Pathologie Groep Offerhaus, Pathologie Pathologen staf, MS MDL Oncologie, Backes, Yara, Elias, Sjoerd G., Groen, John N., Schwartz, Matthijs P., Wolfhagen, Frank H.J., Geesing, Joost M.J., ter Borg, Frank, van Bergeijk, Jeroen, Spanier, Bernhard W.M., de Vos tot Nederveen Cappel, Wouter H., Kessels, Koen, Seldenrijk, Cornelis A., Raicu, Mihaela G., Drillenburg, Paul, Milne, Anya N., Kerkhof, Marjon, Seerden, Tom C.J., Siersema, Peter D., Vleggaar, Frank P., Offerhaus, G. Johan A., Lacle, Miangela M., Moons, Leon M.G., Dutch T1 CRC Working Group, MS MDL 1, Cancer, Epi Kanker Team A, JC onderzoeksprogramma Kanker, MS CGO, Pathologie Groep Offerhaus, Pathologie Pathologen staf, MS MDL Oncologie, Backes, Yara, Elias, Sjoerd G., Groen, John N., Schwartz, Matthijs P., Wolfhagen, Frank H.J., Geesing, Joost M.J., ter Borg, Frank, van Bergeijk, Jeroen, Spanier, Bernhard W.M., de Vos tot Nederveen Cappel, Wouter H., Kessels, Koen, Seldenrijk, Cornelis A., Raicu, Mihaela G., Drillenburg, Paul, Milne, Anya N., Kerkhof, Marjon, Seerden, Tom C.J., Siersema, Peter D., Vleggaar, Frank P., Offerhaus, G. Johan A., Lacle, Miangela M., Moons, Leon M.G., and Dutch T1 CRC Working Group

Published
2018

15. Improved diagnostic stratification of digitised Barrett's oesophagus biopsies by p53 immunohistochemical staining

Author

Pathologie Groep Bovenschen, Pathologie Opleiding, Pathologie Pathologen staf, Cancer, van der Wel, Myrtle J., Duits, Lucas C., Pouw, Roos E., Seldenrijk, Cornelis A., Offerhaus, G. J.A., Visser, Mike, ten Kate, Fiebo J., Biermann, Katharina, Brosens, Lodewijk A.A., Doukas, Michael, Huysentruyt, Clement, Karrenbeld, Arend, Kats-Ugurlu, Gursah, van der Laan, Jaap S., van Lijnschoten, G. Ineke, Moll, Freek C.P., Ooms, Ariadne H.A.G., van der Valk, Hans, Tijssen, Jan G., Bergman, Jacques J., Meijer, Sybren L., Pathologie Groep Bovenschen, Pathologie Opleiding, Pathologie Pathologen staf, Cancer, van der Wel, Myrtle J., Duits, Lucas C., Pouw, Roos E., Seldenrijk, Cornelis A., Offerhaus, G. J.A., Visser, Mike, ten Kate, Fiebo J., Biermann, Katharina, Brosens, Lodewijk A.A., Doukas, Michael, Huysentruyt, Clement, Karrenbeld, Arend, Kats-Ugurlu, Gursah, van der Laan, Jaap S., van Lijnschoten, G. Ineke, Moll, Freek C.P., Ooms, Ariadne H.A.G., van der Valk, Hans, Tijssen, Jan G., Bergman, Jacques J., and Meijer, Sybren L.

Published
2018

16. Tumour‐stroma ratio has poor prognostic value in nonpedunculated T1 colorectal cancer: A multicentre case‐cohort study

Author

Dang, Hao, van Pelt, Gabi W., Haasnoot, Krijn J. C., Backes, Yara, Elias, Sjoerd G., Seerden, Tom C. J., Schwartz, Matthijs P., Spanier, Bernhard W. M., de Vos tot Nederveen Cappel, Wouter H., van Bergeijk, Jeroen D., Kessels, Koen, Geesing, Joost M. J., Groen, John N., Borg, Frank ter, Wolfhagen, Frank H. J., Seldenrijk, Cornelis A., Raicu, Mihaela G., Milne, Anya N., van Lent, Anja U. G., Brosens, Lodewijk A. A., Johan A. Offerhaus, G., Siersema, Peter D., Tollenaar, Rob A. E. M., Hardwick, James C. H., Hawinkels, Lukas J. A. C., Moons, Leon M. G., Lacle, Miangela M., Mesker, Wilma E., and Boonstra, Jurjen J.

Abstract

Current risk stratification models for early invasive (T1) colorectal cancer are not able to discriminate accurately between prognostic favourable and unfavourable tumours, resulting in over‐treatment of a large (>80%) proportion of T1 colorectal cancer patients. The tumour‐stroma ratio (TSR), which is a measure for the relative amount of desmoplastic tumour stroma, is reported to be a strong independent prognostic factor in advanced‐stage colorectal cancer, with a high stromal content being associated with worse prognosis and survival. We aimed to investigate whether the TSR predicts clinical outcome in patients with non‐pedunculated T1 colorectal cancer. Haematoxylin and eosin (H&E)‐stained tumour tissue slides from a retrospective multicentre case cohort of patients with nonpedunculated surgically treated T1 colorectal cancer were assessed for TSR by two independent observers who were blinded for clinical outcomes. The primary end point was adverse outcome, which was defined as the presence of lymph node metastasis in the resection specimen or colorectal cancer recurrence during follow‐up. All 261 patients in the case cohort had H&E slides available for TSR scoring. Of these, 183 were scored as stroma‐low, and 78 were scored as stroma‐high. There was moderate inter‐observer agreement κ = 0.42). In total, 41 patients had lymph node metastasis, 17 patients had recurrent cancer and five had both. Stroma‐high tumours were not associated with an increased risk for an adverse outcome (adjusted hazard ratio = 0.66, 95% confidence interval 0.37–1.18; p= 0.163). Our study emphasises that existing prognosticators may not be simply extrapolated to T1 colorectal cancers, even though their prognostic value has been widely validated in more advanced‐stage tumours.

Published
2021
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17. Improved diagnostic stratification of digitised Barrett's oesophagus biopsies by p53 immunohistochemical staining

Author

van der Wel, Myrtle J, primary, Duits, Lucas C, additional, Pouw, Roos E, additional, Seldenrijk, Cornelis A, additional, Offerhaus, G J A, additional, Visser, Mike, additional, ten Kate, Fiebo J, additional, Biermann, Katharina, additional, Brosens, Lodewijk A A, additional, Doukas, Michael, additional, Huysentruyt, Clement, additional, Karrenbeld, Arend, additional, Kats‐Ugurlu, Gursah, additional, van der Laan, Jaap S, additional, van Lijnschoten, G (Ineke), additional, Moll, Freek C P, additional, Ooms, Ariadne H A G, additional, van der Valk, Hans, additional, Tijssen, Jan G, additional, Bergman, Jacques J, additional, and Meijer, Sybren L, additional

Published
2018
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18. Tumour–stroma ratio has poor prognostic value in non-pedunculated T1 colorectal cancer: A multi-centre case-cohort study

Author

Dang, Hao, van Pelt, Gabi W, Haasnoot, Krijn JC, Backes, Yara, Elias, Sjoerd G, Seerden, Tom CJ, Schwartz, Matthijs P, Spanier, Bernhard WM, de Vos tot Nederveen Cappel, Wouter H, van Bergeijk, Jeroen D, Kessels, Koen, Geesing, Joost MJ, Groen, John N, ter Borg, Frank, Wolfhagen, Frank HJ, Seldenrijk, Cornelis A, Raicu, Mihaela G, Milne, Anya N, van Lent, Anja UG, Brosens, Lodewijk AA, Offerhaus, G Johan A, Siersema, Peter D, Tollenaar, Rob AEM, Hardwick, James CH, Hawinkels, Lukas JAC, Moons, Leon MG, Lacle, Miangela M, Mesker, Wilma E, and Boonstra, Jurjen J

Abstract

Background Current risk stratification models for early invasive (T1) colorectal cancer are not able to discriminate accurately between prognostic favourable and unfavourable tumours, resulting in over-treatment of a large (>80%) proportion of T1 colorectal cancer patients. The tumour–stroma ratio (TSR), which is a measure for the relative amount of desmoplastic tumour stroma, is reported to be a strong independent prognostic factor in advanced-stage colorectal cancer, with a high stromal content being associated with worse prognosis and survival. We aimed to investigate whether the TSR predicts clinical outcome in patients with non-pedunculated T1 colorectal cancer.Methods Hematoxylin and eosin (H&E)-stained tumour tissue slides from a retrospective multi-centre case cohort of patients with non-pedunculated surgically treated T1 colorectal cancer were assessed for TSR by two independent observers who were blinded for clinical outcomes. The primary end point was adverse outcome, which was defined as the presence of lymph node metastasis in the resection specimen or colorectal cancer recurrence during follow-up.Results All 261 patients in the case cohort had H&E slides available for TSR scoring. Of these, 183 were scored as stroma-low, and 78 were scored as stroma-high. There was moderate inter-observer agreement (κ = 0.42). In total, 41 patients had lymph node metastasis, 17 patients had recurrent cancer and five had both. Stroma-high tumours were not associated with an increased risk for an adverse outcome (adjusted hazard ratio = 0.66, 95% confidence interval 0.37–1.18; p= 0.163).Conclusions Our study emphasises that existing prognosticators may not be simply extrapolated to T1 colorectal cancers, even though their prognostic value has been widely validated in more advanced-stage tumours.

Published
2024
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19. Detection of palisade vessels as a landmark for Barrett’s esophagus in a Western population

Author

Schölvinck, Dirk W., primary, Goto, Osamu, additional, Seldenrijk, Cornelis A., additional, Bisschops, Raf, additional, Horii, Joichiro, additional, Ochiai, Yasutoshi, additional, Schoon, Erik J., additional, Schenk, Boudewijn E., additional, Uraoka, Toshio, additional, van Oijen, Martijn G. H., additional, Bergman, Jacques J. G. H. M., additional, Yahagi, Naohisa, additional, and Weusten, Bas L. A. M., additional

Published
2015
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20. Tumour-stroma ratio has poor prognostic value in non-pedunculated T1 colorectal cancer: A multi-centre case-cohort study.

Author

Dang H, van Pelt GW, Haasnoot KJ, Backes Y, Elias SG, Seerden TC, Schwartz MP, Spanier BW, de Vos Tot Nederveen Cappel WH, van Bergeijk JD, Kessels K, Geesing JM, Groen JN, Ter Borg F, Wolfhagen FH, Seldenrijk CA, Raicu MG, Milne AN, van Lent AU, Brosens LA, Offerhaus GJA, Siersema PD, Tollenaar RA, Hardwick JC, Hawinkels LJ, Moons LM, Lacle MM, Mesker WE, and Boonstra JJ

Abstract

Background: Current risk stratification models for early invasive (T1) colorectal cancer are not able to discriminate accurately between prognostic favourable and unfavourable tumours, resulting in over-treatment of a large (>80%) proportion of T1 colorectal cancer patients. The tumour-stroma ratio (TSR), which is a measure for the relative amount of desmoplastic tumour stroma, is reported to be a strong independent prognostic factor in advanced-stage colorectal cancer, with a high stromal content being associated with worse prognosis and survival. We aimed to investigate whether the TSR predicts clinical outcome in patients with non-pedunculated T1 colorectal cancer., Methods: Hematoxylin and eosin (H&E)-stained tumour tissue slides from a retrospective multi-centre case cohort of patients with non-pedunculated surgically treated T1 colorectal cancer were assessed for TSR by two independent observers who were blinded for clinical outcomes. The primary end point was adverse outcome, which was defined as the presence of lymph node metastasis in the resection specimen or colorectal cancer recurrence during follow-up., Results: All 261 patients in the case cohort had H&E slides available for TSR scoring. Of these, 183 were scored as stroma-low, and 78 were scored as stroma-high. There was moderate inter-observer agreement (κ = 0.42). In total, 41 patients had lymph node metastasis, 17 patients had recurrent cancer and five had both. Stroma-high tumours were not associated with an increased risk for an adverse outcome (adjusted hazard ratio = 0.66, 95% confidence interval 0.37-1.18; p  = 0.163)., Conclusions: Our study emphasises that existing prognosticators may not be simply extrapolated to T1 colorectal cancers, even though their prognostic value has been widely validated in more advanced-stage tumours.

Published
2020
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