Search

The nasal epithelium houses a population of solitary chemosensory cells (SCCs). SCCs express bitter taste receptors and taste transduction signaling components and are innervated by peptidergic trigeminal polymodal nociceptive nerve fibers. Thus, nasal SCCs respond to bitter compounds, including bacterial metabolites, and these reactions evoke protective respiratory reflexes and innate immune and inflammatory responses. We tested whether SCCs are implicated in aversive behavior to specific inhaled nebulized irritants using a custom-built dual-chamber forced-choice device. The behavior of mice was recorded and analyzed for the time spent in each chamber. Wild-type (WT) mice exhibited an aversion to 10 mmdenatonium benzoate (Den) or cycloheximide and spent more time in the control (saline) chamber. The SCC-pathway knock-out (KO) mice did not exhibit such an aversion response. The bitter avoidance behavior of WT mice was positively correlated with the concentration increase of Den and the number of exposures. Bitter-ageusic P2X2/3 double KO mice similarly showed an avoidance response to nebulized Den, excluding the taste system’s involvement and pointing to an SCC-mediated major contributor to the aversive response. Interestingly, SCC-pathway KO mice showed an attraction to higher Den concentrations; however, chemical ablation of the olfactory epithelium eliminated this attraction attributed to the smell of Den. These results demonstrate that activation of SCCs leads to a rapid aversive response to certain classes of irritants with olfaction, but not gustation, contributing to the avoidance behavior during subsequent irritant exposures. This SCC-mediated avoidance behavior represents an important defense mechanism against the inhalation of noxious chemicals.

Success in the field of recreation management requires a variety of 21st-century skills including the abilities to solve complex problems, think creatively, and collaborate with peers. Research sug...

We present a wavelet-based algorithm to identify dwarf galaxies in the Milky Way in ${\it Gaia}$ DR2 data. Our algorithm detects overdensities in 4D position--proper motion space, making it the first search to explicitly use velocity information to search for dwarf galaxy candidates. We optimize our algorithm and quantify its performance by searching for mock dwarfs injected into ${\it Gaia}$ DR2 data and for known Milky Way satellite galaxies. Comparing our results with previous photometric searches, we find that our search is sensitive to undiscovered systems at Galactic latitudes~$\lvert b\rvert>20^{\circ}$ and with half-light radii larger than the 50% detection efficiency threshold for Pan-STARRS1 (PS1) at (${\it i}$) absolute magnitudes of =$-7, Comment: 17 pages, 10 figures, 3 tables; submitted to ApJ. Candidate lists available at https://dwarfswaves.github.io. Updated to published version

Early-life adversity can have long-lasting effects on physiological, behavioural, cognitive, and somatic processes. Consequently, these effects may alter an organism’s life-history strategy and reproductive tactics.In response to early-life immune activation, we quantified levels of the acute phase protein haptoglobin (Hp) during development in male zebra finches (Taeniopygia guttata). Then, we examined the long-term impacts of early-life immune activation on an important static sexual signal, song complexity, as well as effects of early-life immune activation on the relationship between song complexity and a dynamic sexual signal, beak colouration. Finally, we performed mate-choice trials to determine if male early-life experience impacted female preference.Challenge with keyhole limpet hemocyanin (KLH) resulted in increased song complexity compared to lipopolysaccharide (LPS) treatment or the control. Hp levels were inversely correlated with song complexity. Moreover, KLH-treatment resulted in negative associations between the two sexual signals (beak colouration and song complexity). Females demonstrated some preference for KLH-treated males over controls and for control males over LPS-treated males in mate choice trials.Developmental immune activation has variable effects on the expression of secondary sexual traits in adulthood, including enhancing the expression of some traits. Because developmental levels of Hp and adult song complexity were correlated, future studies should explore a potential role for exposure to inflammation during development on song learning.Early-life adversity may differentially impact static versus dynamic signals. The use of phenotypic correlations can be a powerful tool for examining the impact of early-life experience on the associations among different traits, including sexual signals.

This article describes a formal proof of the Kepler conjecture on dense sphere packings in a combination of the HOL Light and Isabelle proof assistants. This paper constitutes the official published account of the now completed Flyspeck project., 21 pages

This study aimed to determine if bibliometrics are being sought as part of research award competitions, through an examination of calls for fifteen major Canadian research awards. This study further aimed to determine if there were indications that including bibliometrics in the award application process could be helpful towards a nominee’s success. In so doing, this paper contributes a Canadian perspective to a growing body of related research which has sought to address the lack of clarity in funding application assessment criteria and the role bibliometrics can play in addressing this issue.The study revealed no explicit requests for bibliometric indicators in the calls for nominations for the major research awards examined. Nevertheless, requests for nominees’ CVs and/or publication histories, which can serve as one basis for the bibliometric evaluation of performance, were regularly observed, as were mentions of interest in internationality, which can in turn be illustrated with the use of bibliometrics. Additionally, a prevalence of multidisciplinary review panels was observed, pointing to potential utility of normalized bibliometric indicators in the award nomination process. These findings suggest that there are aspects of award calls that correspond to existing bibliometric indicators, and so their use may be warranted eventhough, so far, they have not been asked for by name.

Existing models for the dependence of the halo mass function on cosmological parameters will become a limiting source of systematic uncertainty for cluster cosmology in the near future. We present a halo mass function emulator and demonstrate improved accuracy relative to state-of-the-art analytic models. In this work, mass is defined using an overdensity criteria of 200 relative to the mean background density. Our emulator is constructed from the AEMULUS simulations, a suite of 40 N-body simulations with snapshots from z=3 to z=0. These simulations cover the flat wCDM parameter space allowed by recent Cosmic Microwave Background, Baryon Acoustic Oscillation and Type Ia Supernovae results, varying the parameters w, Omega_m, Omega_b, sigma_8, N_{eff}, n_s, and H_0. We validate our emulator using five realizations of seven different cosmologies, for a total of 35 test simulations. These test simulations were not used in constructing the emulator, and were run with fully independent initial conditions. We use our test simulations to characterize the modeling uncertainty of the emulator, and introduce a novel way of marginalizing over the associated systematic uncertainty. We confirm non-universality in our halo mass function emulator as a function of both cosmological parameters and redshift. Our emulator achieves better than 1% precision over much of the relevant parameter space, and we demonstrate that the systematic uncertainty in our emulator will remain a negligible source of error for cluster abundance studies through at least the LSST Year 1 data set., Comment: https://aemulusproject.github.io/

The rapidly growing statistical precision of galaxy surveys has lead to a need for ever-more precise predictions of the observables used to constrain cosmological and galaxy formation models. The primary avenue through which such predictions will be obtained is suites of numerical simulations. These simulations must span the relevant model parameter spaces, be large enough to obtain the precision demanded by upcoming data, and be thoroughly validated in order to ensure accuracy. In this paper we present one such suite of simulations, forming the basis for the AEMULUS Project, a collaboration devoted to precision emulation of galaxy survey observables. We have run a set of 75 (1.05 h^-1 Gpc)^3 simulations with mass resolution and force softening of 3.51\times 10^10 (Omega_m / 0.3) ~ h^-1 M_sun and 20 ~ h^-1 kpc respectively in 47 different wCDM cosmologies spanning the range of parameter space allowed by the combination of recent Cosmic Microwave Background, Baryon Acoustic Oscillation and Type Ia Supernovae results. We present convergence tests of several observables including spherical overdensity halo mass functions, galaxy projected correlation functions, galaxy clustering in redshift space, and matter and halo correlation functions and power spectra. We show that these statistics are converged to 1% (2%) for halos with more than 500 (200) particles respectively and scales of r>200 ~ h^-1 kpc in real space or k ~ 3 h Mpc^-1 in harmonic space for z\le 1. We find that the dominant source of uncertainty comes from varying the particle loading of the simulations. This leads to large systematic errors for statistics using halos with fewer than 200 particles and scales smaller than k ~ 4 h^-1 Mpc. We provide the halo catalogs and snapshots detailed in this work to the community at https://AemulusProject.github.io., 16 pages, 12 figures, 3 Tables Project website: https://aemulusproject.github.io/

Using the N-body simulations of the AEMULUS Project, we construct an emulator for the non-linear clustering of galaxies in real and redshift space. We construct our model of galaxy bias using the halo occupation framework, accounting for possible velocity bias. The model includes 15 parameters, including both cosmological and galaxy bias parameters. We demonstrate that our emulator achieves ~ 1% precision at the scales of interest, 0.1, Comment: 14 pages, 8 figures, 1 table; submitted to ApJ; the project webpage is available at https://aemulusproject.github.io ; typo in Figure 7 and caption updated, results unchanged