Search

Your search keyword '"Schoos, Mikkel"' showing total 173 results
Start Over Author "Schoos, Mikkel" Publication Year Range Last 10 years
173 results on '"Schoos, Mikkel"'

5. Usefulness of High Sensitivity Troponin T to Predict Long-Term Left Ventricular Dysfunction After ST-Elevation Myocardial Infarction

Author

Mohammad, Moman A., Koul, Sasha, Lønborg, Jacob Thomsen, Nepper-Christensen, Lars, Høfsten, Dan E., Ahtarovski, Kiril A., Bang, Lia E., Helqvist, Steffen, Kyhl, Kasper, Køber, Lars, Kelbæk, Henning, Vejlstrup, Niels, Holmvang, Lene, Schoos, Mikkel Malby, Göransson, Christoffer, Engstrøm, Thomas, and Erlinge, David

Published
2020
Full Text
View/download PDF

6. Complete Revascularization Versus Culprit Lesion Only in Patients With ST-Segment Elevation Myocardial Infarction and Multivessel Disease: A DANAMI-3–PRIMULTI Cardiac Magnetic Resonance Substudy

Author

Kyhl, Kasper, Ahtarovski, Kiril Aleksov, Nepper-Christensen, Lars, Ekström, Kathrine, Ghotbi, Adam Ali, Schoos, Mikkel, Göransson, Christoffer, Bertelsen, Litten, Helqvist, Steffen, Holmvang, Lene, Jørgensen, Erik, Pedersen, Frants, Saunamäki, Kari, Clemmensen, Peter, De Backer, Ole, Høfsten, Dan Eik, Køber, Lars, Kelbæk, Henning, Vejlstrup, Niels, Lønborg, Jacob, and Engstrøm, Thomas

Published
2019
Full Text
View/download PDF

7. Patterns and Impact of Dual Antiplatelet Cessation on Cardiovascular Risk After Percutaneous Coronary Intervention in Patients With Acute Coronary Syndromes

Author

Schoos, Mikkel, Power, David, Baber, Usman, Sartori, Samantha, Claessen, Bimmer, Camaj, Anton, Steg, Philippe, Ariti, Cono, Weisz, Giora, Witzenbichler, Bernhard, Henry, Timothy, Cohen, David, Antoniucci, David, Krucoff, Mitchell, Hermiller, James, Gibson, Charles, Chieffo, Alaide, Moliterno, David, Colombo, Antonio, Pocock, Stuart, Dangas, George, and Mehran, Roxana

Published
2019
Full Text
View/download PDF

10. Causes, Timing, and Impact of Dual Antiplatelet Therapy Interruption for Surgery (from the Patterns of Non-adherence to Anti-platelet Regimens In Stented Patients Registry)

Author

Schoos, Mikkel, Chandrasekhar, Jaya, Baber, Usman, Bhasin, Aarti, Sartori, Samantha, Aquino, Melissa, Vogel, Birgit, Farhan, Serdar, Sorrentino, Sabato, Kini, Annapoorna, Kruckoff, Mitchell, Moliterno, David, Henry, Timothy D., Weisz, Giora, Gibson, C. Michael, Iakovou, Ioannis, Colombo, Antonio, Steg, P. Gabriel, Witzenbichler, Bernhard, Chieffo, Alaide, Cohen, David, Stuckey, Thomas, Ariti, Cono, Dangas, George, Pocock, Stuart, and Mehran, Roxana

Published
2017
Full Text
View/download PDF

12. Impact of Hemoglobin A1c Levels on Residual Platelet Reactivity and Outcomes After Insertion of Coronary Drug-Eluting Stents (from the ADAPT-DES Study)

Author

Schoos, Mikkel M., Dangas, George D., Mehran, Roxana, Kirtane, Ajay J., Yu, Jennifer, Litherland, Claire, Clemmensen, Peter, Stuckey, Thomas D., Witzenbichler, Bernhard, Weisz, Giora, Rinaldi, Michael J., Neumann, Franz-Josef, Metzger, D. Christopher, Henry, Timothy D., Cox, David A., Duffy, Peter L., Brodie, Bruce R., Mazzaferri, Ernest L., Jr., Maehara, Akiko, and Stone, Gregg W.

Published
2016
Full Text
View/download PDF

14. Balancing the Risk of Bleeding and Stroke in Patients With Atrial Fibrillation After Percutaneous Coronary Intervention (from the AVIATOR Registry)

Author

Mennuni, Marco G., Halperin, Jonathan L., Bansilal, Sameer, Schoos, Mikkel M., Theodoropoulos, Kleanthis N., Meelu, Omar A., Sartori, Samantha, Giacoppo, Daniele, Bernelli, Chiara, Moreno, Pedro R., Krishnan, Prakash, Baber, Usman, Lucarelli, Carla, Dangas, George D., Sharma, Samin K., Kini, Annapoorna S., Tamburino, Corrado, Chieffo, Alaide, Colombo, Antonio, Presbitero, Patrizia, and Mehran, Roxana

Published
2015
Full Text
View/download PDF

17. Polypill Strategy in Secondary Cardiovascular Prevention

Author

Castellano, Jose M, Pocock, Stuart J, Bhatt, Deepak L, Quesada, Antonio J, Owen, Ruth, Fernandez-Ortiz, Antonio, Sanchez, Pedro L, Marin Ortuño, Francisco, Vazquez Rodriguez, Jose M, Domingo-Fernández, Alexandra, Lozano, Iñigo, Roncaglioni, Maria C, Baviera, Marta, Foresta, Andreana, Ojeda-Fernandez, Luisa, Colivicchi, Furio, Di Fusco, Stefania A, Doehner, Wolfram, Meyer, Antje, Schiele, François, Ecarnot, Fiona, Linhart, Aleš, Lubanda, Jean-Claude, Barczi, Gyorgy, Merkely, Bela, Ponikowski, Piotr, Kasprzak, Marta, Fernandez Alvira, Juan M, Andres, Vicente, Bueno, Hector, Collier, Timothy, Van de Werf, Frans, Perel, Pablo, Rodriguez-Manero, Moises, Alonso Garcia, Angeles, Proietti, Marco, Schoos, Mikkel M, Simon, Tabassome, Fernandez Ferro, Jose, Lopez, Nicolas, Beghi, Ettore, Bejot, Yannick, Vivas, David, Cordero, Alberto, Ibañez, Borja, Fuster, Valentin, and SECURE Investigators

Subjects
Aspirin, Ramipril, Cardiovascular Diseases, Atorvastatin, Myocardial Infarction, Secondary Prevention, Humans, Angiotensin-Converting Enzyme Inhibitors, General Medicine, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Platelet Aggregation Inhibitors, Ischemic Stroke
Abstract

BACKGROUND: A polypill that includes key medications associated with improved outcomes (aspirin, angiotensin-converting-enzyme [ACE] inhibitor, and statin) has been proposed as a simple approach to the secondary prevention of cardiovascular death and complications after myocardial infarction. METHODS: In this phase 3, randomized, controlled clinical trial, we assigned patients with myocardial infarction within the previous 6 months to a polypill-based strategy or usual care. The polypill treatment consisted of aspirin (100 mg), ramipril (2.5, 5, or 10 mg), and atorvastatin (20 or 40 mg). The primary composite outcome was cardiovascular death, nonfatal type 1 myocardial infarction, nonfatal ischemic stroke, or urgent revascularization. The key secondary end point was a composite of cardiovascular death, nonfatal type 1 myocardial infarction, or nonfatal ischemic stroke. RESULTS: A total of 2499 patients underwent randomization and were followed for a median of 36 months. A primary-outcome event occurred in 118 of 1237 patients (9.5%) in the polypill group and in 156 of 1229 (12.7%) in the usual-care group (hazard ratio, 0.76; 95% confidence interval [CI], 0.60 to 0.96; P = 0.02). A key secondary-outcome event occurred in 101 patients (8.2%) in the polypill group and in 144 (11.7%) in the usual-care group (hazard ratio, 0.70; 95% CI, 0.54 to 0.90; P = 0.005). The results were consistent across prespecified subgroups. Medication adherence as reported by the patients was higher in the polypill group than in the usual-care group. Adverse events were similar between groups. CONCLUSIONS: Treatment with a polypill containing aspirin, ramipril, and atorvastatin within 6 months after myocardial infarction resulted in a significantly lower risk of major adverse cardiovascular events than usual care. (Funded by the European Union Horizon 2020; SECURE ClinicalTrials.gov number, NCT02596126; EudraCT number, 2015-002868-17.).

Published
2022

22. Association Between Early Q Waves and Reperfusion Success in Patients With ST-Segment–Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention: A Cardiac Magnetic Resonance Imaging Study

Author

Topal, Divan Gabriel, Lønborg, Jacob, Ahtarovski, Kiril Aleksov, Nepper-Christensen, Lars, Helqvist, Steffen, Holmvang, Lene, Pedersen, Frants, Clemmensen, Peter, Saünamaki, Kari, Jørgensen, Erik, Kyhl, Kasper, Ghotbi, Ali, Schoos, Mikkel Malby, Göransson, Christoffer, Bertelsen, Litten, Høfsten, Dan, Køber, Lars, Kelbæk, Henning, Vejlstrup, Niels, and Engstrøm, Thomas

Published
2017
Full Text
View/download PDF

25. Ischemia From Nonculprit Stenoses Is Not Associated With Reduced Culprit Infarct Size in Patients with ST-Segment–Elevation Myocardial Infarction

Author

Ekström, Kathrine, primary, Nielsen, Julie V.W., additional, Nepper-Christensen, Lars, additional, Ahtarovski, Kiril A., additional, Kyhl, Kasper, additional, Göransson, Christoffer, additional, Bertelsen, Litten, additional, Ghotbi, Adam A., additional, Kelbæk, Henning, additional, Høfsten, Dan E., additional, Køber, Lars, additional, Schoos, Mikkel M., additional, Vejlstrup, Niels, additional, Lønborg, Jacob, additional, and Engstrøm, Thomas, additional

Published
2021
Full Text
View/download PDF

26. Impact of age on reperfusion success and long-term prognosis in ST-segment elevation myocardial infarction – A cardiac magnetic resonance imaging study

Author

Gabriel Topal, Divan, primary, Aleksov Ahtarovski, Kiril, additional, Lønborg, Jacob, additional, Høfsten, Dan, additional, Nepper-Christensen, Lars, additional, Kyhl, Kasper, additional, Schoos, Mikkel, additional, Ghotbi, Adam Ali, additional, Göransson, Christoffer, additional, Bertelsen, Litten, additional, Holmvang, Lene, additional, Helqvist, Steffen, additional, Pedersen, Frants, additional, Schnabel, Renate, additional, Køber, Lars, additional, Kelbæk, Henning, additional, Vejlstrup, Niels, additional, Engstrøm, Thomas, additional, and Clemmensen, Peter, additional

Published
2021
Full Text
View/download PDF

27. Fractional flow reserve-guided PCI in patients with and without left ventricular hypertrophy: a DANAMI-3-PRIMULTI substudy

Author

Sabbah, Muhammad, primary, Nepper-Christensen, Lars, additional, Lønborg, Jacob, additional, Helqvist, Steffen, additional, Køber, Lars, additional, Høfsten, Dan Eik, additional, Ahtarovski, Kiril Aleksov, additional, Göransson, Christoffer, additional, Kyhl, Kasper, additional, Schoos, Mikkel Malby, additional, Vejlstrup, Niels, additional, Kelbæk, Henning, additional, and Engstrøm, Thomas, additional

Published
2020
Full Text
View/download PDF

28. Infarct size following loading with Ticagrelor/Prasugrel versus Clopidogrel in ST-segment elevation myocardial infarction

Author

Sabbah, Muhammad, primary, Nepper-Christensen, Lars, additional, Køber, Lars, additional, Høfsten, Dan Eik, additional, Ahtarovski, Kiril Aleksov, additional, Göransson, Christoffer, additional, Kyhl, Kasper, additional, Ghotbi, Adam Ali, additional, Schoos, Mikkel Malby, additional, Sadjadieh, Golnaz, additional, Kelbæk, Henning, additional, Lønborg, Jacob, additional, and Engstrøm, Thomas, additional

Published
2020
Full Text
View/download PDF

29. Clinical outcome following late reperfusion with percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction

Author

Nepper-Christensen, Lars, primary, Lønborg, Jacob, additional, Høfsten, Dan Eik, additional, Sadjadieh, Golnaz, additional, Schoos, Mikkel Malby, additional, Pedersen, Frants, additional, Jørgensen, Erik, additional, Kelbæk, Henning, additional, Haahr-Pedersen, Sune, additional, Flensted Lassen, Jens, additional, Køber, Lars, additional, Holmvang, Lene, additional, and Engstrøm, Thomas, additional

Published
2020
Full Text
View/download PDF

30. Myocardial damage after ST-segment elevation myocardial infarction by use of bivalirudin or heparin: a DANAMI-3 substudy

Author

Schoos, Mikkel M., primary, Nepper-Christensen, Lars, additional, Ahtarovski, Kiril Aleksov, additional, Kyhl, Kasper, additional, Göransson, Christoffer, additional, Holmvang, Lene, additional, Kelbæk, Henning, additional, Helqvist, Steffen, additional, Høfsten, Dan Eik, additional, Køber, Lars, additional, Vejlstrup, Niels, additional, Lønborg, Jacob, additional, and Engstrøm, Thomas, additional

Published
2020
Full Text
View/download PDF

31. Sub-acute cardiac magnetic resonance to predict irreversible reduction in left ventricular ejection fraction after ST-segment elevation myocardial infarction: A DANAMI-3 sub-study

Author

Alzuhairi, Karam Sadoon, primary, Lønborg, Jacob, additional, Ahtarovski, Kiril Aleksov, additional, Nepper-Christensen, Lars, additional, Kyhl, Kasper, additional, Lassen, Jens F., additional, Sørensen, Rikke, additional, Joshi, Francis, additional, Ghotbi, Adam Ali, additional, Schoos, Mikkel, additional, Goransson, Christoffer, additional, Bertelsen, Litten, additional, Helqvist, Steffen, additional, Holmvang, Lene, additional, Jørgensen, Erik, additional, Pedersen, Frants, additional, Tilsted, Hans-Henrik, additional, Høfsten, Dan, additional, Køber, Lars, additional, Kelbæk, Henning, additional, Vejlstrup, Niels, additional, and Engstrøm, Thomas, additional

Published
2020
Full Text
View/download PDF

32. Impact of Multiple Myocardial Scars Detected by CMR in Patients Following STEMI

Author

Ekström, Kathrine, primary, Nepper-Christensen, Lars, additional, Ahtarovski, Kiril A., additional, Kyhl, Kasper, additional, Göransson, Christoffer, additional, Bertelsen, Litten, additional, Ghotbi, Adam A., additional, Kelbæk, Henning, additional, Helqvist, Steffen, additional, Høfsten, Dan E., additional, Køber, Lars, additional, Schoos, Mikkel M., additional, Vejlstrup, Niels, additional, Lønborg, Jacob, additional, and Engstrøm, Thomas, additional

Published
2019
Full Text
View/download PDF

33. Complete Revascularization Versus Culprit Lesion Only in Patients With ST-Segment Elevation Myocardial Infarction and Multivessel Disease:A DANAMI-3–PRIMULTI Cardiac Magnetic Resonance Substudy

Author

Kyhl, Kasper, Ahtarovski, Kiril Aleksov, Nepper-Christensen, Lars, Ekström, Kathrine, Ghotbi, Adam Ali, Schoos, Mikkel, Göransson, Christoffer, Bertelsen, Litten, Helqvist, Steffen, Holmvang, Lene, Jørgensen, Erik, Pedersen, Frants, Saunamäki, Kari, Clemmensen, Peter, De Backer, Ole, Høfsten, Dan Eik, Køber, Lars, Kelbæk, Henning, Vejlstrup, Niels, Lønborg, Jacob, and Engstrøm, Thomas

Subjects
ST-segment elevation myocardial infarction, cardiovascular magnetic resonance, complete revascularization, acute myocardial infarction, cardiovascular diseases, cardiac function, cardiac remodeling, randomization, primary percutaneous coronary intervention, randomized study, culprit lesion
Abstract

Objectives: The aim of this study was to evaluate the effect of fractional flow reserve (FFR)–guided revascularization compared with culprit-only percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI) on infarct size, left ventricular (LV), function, LV remodeling, and the presence of nonculprit infarctions. Background: Patients with STEMI with multivessel disease might have improved clinical outcomes after complete revascularization compared with PCI of the infarct-related artery only, but the impact on infarct size, LV function, and remodeling as well as the risk for periprocedural infarction are unknown. Methods: In this substudy of the DANAMI-3 (Third Danish Trial in Acute Myocardial Infarction)–PRIMULTI (Primary PCI in Patients With ST-Elevation Myocardial Infarction and Multivessel Disease: Treatment of Culprit Lesion Only or Complete Revascularization) randomized trial, patients with STEMI with multivessel disease were randomized to receive either complete FFR-guided revascularization or PCI of the culprit vessel only. The patients underwent cardiac magnetic resonance imaging during index admission and at 3-month follow-up. Results: A total of 280 patients (136 patients with infarct-related and 144 with complete FFR-guided revascularization) were included. There were no differences in final infarct size (median 12% [interquartile range: 5% to 19%] vs. 11% [interquartile range: 4% to 18%]; p = 0.62), myocardial salvage index (median 0.71 [interquartile range: 0.54 to 0.89] vs. 0.66 [interquartile range: 0.55 to 0.87]; p = 0.49), LV ejection fraction (mean 58 ± 9% vs. 59 ± 9%; p = 0.39), and LV end-systolic volume remodeling (mean 7 ± 22 ml vs. 7 ± 19 ml; p = 0.63). New nonculprit infarction occurring after the nonculprit intervention was numerically more frequent among patients treated with complete revascularization (6 [4.5%] vs. 1 [0.8%]; p = 0.12). Conclusions: Complete FFR-guided revascularization in patients with STEMI and multivessel disease did not affect final infarct size, LV function, or remodeling compared with culprit-only PCI.

Published
2019

36. Clinical outcome following late reperfusion with percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction

Author

Nepper-Christensen, Lars, Lønborg, Jacob, Høfsten, Dan Eik, Sadjadieh, Golnaz, Schoos, Mikkel Malby, Pedersen, Frants, Jørgensen, Erik, Kelbæk, Henning, Haahr-Pedersen, Sune, Flensted Lassen, Jens, Køber, Lars, Holmvang, Lene, and Engstrøm, Thomas

Abstract

Background: Up to 40% of patients with ST-segment elevation myocardial infarction (STEMI) present later than 12 hours after symptom onset. However, data on clinical outcomes in STEMI patients treated with primary percutaneous coronary intervention 12 or more hours after symptom onset are non-existent. We evaluated the association between primary percutaneous coronary intervention performed later than 12 hours after symptom onset and clinical outcomes in a large all-comer contemporary STEMI cohort.Methods: All STEMI patients treated with primary percutaneous coronary intervention in eastern Denmark from November 2009 to November 2016 were included and stratified by timing of the percutaneous coronary intervention. The combined clinical endpoint of all-cause mortality and hospitalisation for heart failure was identified from nationwide Danish registries.Results: We included 6674 patients: 6108 (92%) were treated less than 12 hours and 566 (8%) were treated 12 or more hours after symptom onset. During a median follow-up period of 3.8 (interquartile range 2.3–5.6) years, 30-day, one-year and long-term cumulative rates of the combined endpoint were 11%, 17% and 25% in patients treated 12 or fewer hours and 21%, 29% and 37% in patients treated more than 12 hours (P<0.001 for all) after symptom onset. Late presentation was independently associated with an increased risk of an adverse clinical outcome (hazard ratio 1.42, 95% confidence interval 1.22–1.66; P<0.001).Conclusions: Increasing duration from symptom onset to primary percutaneous coronary intervention was associated with an increased risk of an adverse clinical outcome in patients with STEMI, especially when the delay exceeded 12 hours.

Published
2024
Full Text
View/download PDF

37. Importance of elevated heart rate in the very early phase of ST-segment elevation myocardial infarction: Results from the DANAMI-3 trial

Author

Nepper-Christensen, Lars, primary, Lønborg, Jacob, additional, Ahtarovski, Kiril A, additional, Høfsten, Dan E, additional, Kyhl, Kasper, additional, Schoos, Mikkel M, additional, Göransson, Christoffer, additional, Laursen, Peter N, additional, Sadjadieh, Golnaz, additional, Ghotbi, Adam Ali, additional, Bertelsen, Litten, additional, Køber, Lars, additional, Helqvist, Steffen, additional, Pedersen, Frants, additional, Jørgensen, Erik, additional, Kelbæk, Henning, additional, Vejlstrup, Niels, additional, Holmvang, Lene, additional, and Engstrøm, Thomas, additional

Published
2018
Full Text
View/download PDF

38. Assessment of the myocardial area at risk: comparing T2-weighted cardiovascular magnetic resonance imaging with contrast-enhanced cine (CE-SSFP) imaging—a DANAMI3 substudy

Author

Göransson, Christoffer, primary, Ahtarovski, Kiril Aleksov, additional, Kyhl, Kasper, additional, Lønborg, Jacob, additional, Nepper-Christensen, Lars, additional, Bertelsen, Litten, additional, Ghotbi, Adam Ali, additional, Schoos, Mikkel Malby, additional, Køber, Lars, additional, Høfsten, Dan, additional, Helqvist, Steffen, additional, Kelbæk, Henning, additional, Engstrøm, Thomas, additional, and Vejlstrup, Niels, additional

Published
2018
Full Text
View/download PDF

39. MR‐proADM as a Prognostic Marker in Patients With ST‐Segment–Elevation Myocardial Infarction—DANAMI‐3 (a Danish Study of Optimal Acute Treatment of Patients With STEMI) Substudy

Author

Falkentoft, Alexander C., primary, Rørth, Rasmus, additional, Iversen, Kasper, additional, Høfsten, Dan E., additional, Kelbæk, Henning, additional, Holmvang, Lene, additional, Frydland, Martin, additional, Schoos, Mikkel M., additional, Helqvist, Steffen, additional, Axelsson, Anna, additional, Clemmensen, Peter, additional, Jørgensen, Erik, additional, Saunamäki, Kari, additional, Tilsted, Hans‐Henrik, additional, Pedersen, Frants, additional, Torp‐Pedersen, Christian, additional, Kofoed, Klaus F., additional, Goetze, Jens P., additional, Engstrøm, Thomas, additional, and Køber, Lars, additional

Published
2018
Full Text
View/download PDF

40. Electrocardiographic scores of severity and acuteness of myocardial ischemia predict myocardial salvage in patients with anterior ST-segment elevation myocardial infarction

Author

Fakhri, Yama, primary, Sejersten, Maria, additional, Schoos, Mikkel Malby, additional, Hansen, Henrik Steen, additional, Dubois-Rande, Jean-Luc, additional, Hall, Trygve S., additional, Larsen, Alf-Inge, additional, Jensen, Svend Eggert, additional, Engblom, Henrik, additional, Arheden, Hakon, additional, Kastrup, Jens, additional, Atar, Dan, additional, and Clemmensen, Peter, additional

Published
2018
Full Text
View/download PDF

41. Electrocardiographic scores of severity and acuteness of myocardial ischemia predict myocardial salvage in patients with anterior ST-segment elevation myocardial infarction

Author

Arheden, Hakon, primary, Atar, Dan, additional, Dubois-Rande, Jean-Luc, additional, Fakhri, Yama, additional, Hansen, Henrik Steen, additional, Jensen, Svend Eggert, additional, Kastrup, Jens, additional, Larsen, Alf-Inge, additional, Clemmensen, Peter, additional, Schoos, Mikkel Malby, additional, and Sejersten, Maria, additional

Published
2017
Full Text
View/download PDF

42. Myocardial Damage in Patients With Deferred Stenting After STEMI

Author

Lønborg, Jacob, primary, Engstrøm, Thomas, additional, Ahtarovski, Kiril Aleksov, additional, Nepper-Christensen, Lars, additional, Helqvist, Steffen, additional, Vejlstrup, Niels, additional, Kyhl, Kasper, additional, Schoos, Mikkel Malby, additional, Ghotbi, Ali, additional, Göransson, Christoffer, additional, Bertelsen, Litten, additional, Holmvang, Lene, additional, Pedersen, Frants, additional, Jørgensen, Erik, additional, Saunamäki, Kari, additional, Clemmensen, Peter, additional, De Backer, Ole, additional, Kløvgaard, Lene, additional, Høfsten, Dan Eik, additional, Køber, Lars, additional, and Kelbæk, Henning, additional

Published
2017
Full Text
View/download PDF

43. Left Ventricular Hypertrophy Is Associated With Increased Infarct Size and Decreased Myocardial Salvage in Patients With ST‐Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

Author

Nepper‐Christensen, Lars, primary, Lønborg, Jacob, additional, Ahtarovski, Kiril Aleksov, additional, Høfsten, Dan Eik, additional, Kyhl, Kasper, additional, Ghotbi, Adam Ali, additional, Schoos, Mikkel Malby, additional, Göransson, Christoffer, additional, Bertelsen, Litten, additional, Køber, Lars, additional, Helqvist, Steffen, additional, Pedersen, Frants, additional, Saünamaki, Kari, additional, Jørgensen, Erik, additional, Kelbæk, Henning, additional, Holmvang, Lene, additional, Vejlstrup, Niels, additional, and Engstrøm, Thomas, additional

Published
2017
Full Text
View/download PDF

48. Prevalence, Impact, and Predictive Value of Detecting Subclinical Coronary and Carotid Atherosclerosis in Asymptomatic Adults:The BioImage Study

Author

Baber, Usman, Mehran, Roxana, Sartori, Samantha, Schoos, Mikkel Malby, Sillesen, Henrik, Muntendam, Pieter, Garcia, Mario J., Gregson, John, Pocock, Stuart, Falk, Erling, and Fuster, Valentin

Subjects
carotid ultrasound, risk prediction, cardiovascular diseases, atherosclerosis, coronary artery calcification
Abstract

BACKGROUND: Although recent studies suggest that measuring coronary artery calcification (CAC) may be superior to indirect atherosclerotic markers in predicting cardiac risk, there are limited data evaluating imaging-based biomarkers that directly quantify atherosclerosis in different vascular beds performed in a single cohort.OBJECTIVES: The BioImage Study (A Clinical Study of Burden of Atherosclerotic Disease in an At-Risk Population) sought to identify imaging biomarkers that predict near-term (3-year) atherothrombotic events.METHODS: The BioImage Study enrolled 5,808 asymptomatic U.S. adults (mean age: 69 years, 56.5% female) in a prospective cohort evaluating the role of vascular imaging on cardiovascular risk prediction. All patients were evaluated by CAC and novel 3-dimensional carotid ultrasound. Plaque areas from both carotid arteries were summed as the carotid plaque burden (cPB). The primary endpoint was the composite of major adverse cardiac events (MACE) (cardiovascular death, myocardial infarction, and ischemic stroke). A broader secondary MACE endpoint also included all-cause death, unstable angina, and coronary revascularization.RESULTS: Over a median follow-up of 2.7 years, MACE occurred in 216 patients (4.2%), of which 82 (1.5%) were primary events. After adjustment for risk factors, and compared with individuals without any cPB, hazard ratios for MACE were 0.78 (95% confidence interval [CI]: 0.31 to 1.91), 1.45 (95% CI: 0.67 to 3.14), and 2.36 (95% CI: 1.13 to 4.92) with increasing cPB tertile, with similar results for CAC. Net reclassification significantly improved with either cPB (0.23) or CAC (0.25). MACE rates increased simultaneously with higher levels of both cPB and CAC.CONCLUSIONS: Detection of subclinical carotid or coronary atherosclerosis improves risk predictions and reclassification compared with conventional risk factors, with comparable results for either modality. Cost-effective analyses are warranted to define the optimal roles of these complementary techniques. (BioImage Study: A Clinical Study of Burden of Atherosclerotic Disease in an At-Risk Population; NCT00738725).

Published
2015

49. Stroke After Transcatheter Aortic Valve Replacement: Incidence, Risk Factors, Prognosis, and Preventive Strategies

Author

Mastoris, Ioannis, Schoos, Mikkel M., Dangas, George D., and Mehran, Roxana

Subjects
Stroke, Diffusion Magnetic Resonance Imaging, Postoperative Complications, Time Factors, Risk Factors, Aortic Valve, Reviews, Humans, Prognosis, Magnetic Resonance Imaging
Abstract

The first transcatheter aortisc valve replacement (TAVR) was performed in 2002, and has been proven beneficial in inoperable and high-risk patients for open heart surgery. Stroke occurrence after TAVR, both periprocedure and at follow-up, has not been well described. We sought to review incidence, pathophysiology, predictors, prognosis, and current preventive strategies of cerebrovascular accidents (CVAs) after TAVR. Studies were selected from a Medline search if they contained clinical outcomes data after TAVR. Acute and subacute CVAs after TAVR have been reported in 3% to 6% of patients. Approximately 45% of CVAs occur within 2 days after TAVR; 28% between 3 and 10 days; 4% between 10 and 30 days; and 10.5% occur from 1 month to 2 years. Clinically silent cerebral embolisms have been reported, with an incidence greatly exceeding that of overt CVAs. Underlying pathophysiologic mechanisms for CVAs can be broadly categorized into embolic and nonembolic causes, as well as procedural and postprocedural (early and late). Important predictors of early CVAs are small aortic valve area, atrial fibrillation, and balloon postdilation, whereas late CVAs are mostly influenced by chronic atrial fibrillation, prior cerebrovascular disease, and transapical approach. Following stroke, patients exhibit increased morbidity and mortality. A multilevel approach for the prevention of CVAs includes improved interventional techniques, embolic protection devices, antithrombotic treatment, close monitoring, and aggressive management of modifiable risk factors. Technology advances notwithstanding stroke morbidity and mortality remains steady. The significance of silent cerebral embolism on prognosis remains uncertain, and optimal medical treatment during and after TAVR should be further investigated.

Published
2014

50. Assessment of the myocardial area at risk: comparing T2-weighted cardiovascular magnetic resonance imaging with contrast-enhanced cine (CE-SSFP) imaging—a DANAMI3 substudy.

Author

Göransson, Christoffer, Ahtarovski, Kiril Aleksov, Kyhl, Kasper, Lønborg, Jacob, Nepper-Christensen, Lars, Bertelsen, Litten, Ghotbi, Adam Ali, Schoos, Mikkel Malby, Køber, Lars, Høfsten, Dan, Helqvist, Steffen, Kelbæk, Henning, Engstrøm, Thomas, and Vejlstrup, Niels

Subjects
CARDIOMYOPATHIES, CARDIOVASCULAR disease diagnosis, CONFIDENCE intervals, LEFT heart ventricle, MAGNETIC resonance imaging, RESEARCH evaluation, RISK assessment, INTER-observer reliability, DESCRIPTIVE statistics, DIAGNOSIS, CARDIOVASCULAR diseases risk factors
Abstract

Aims Myocardial salvage following treatment for ST-segment elevation myocardial infarction is prognostic for morbidity and mortality. Studies with myocardial salvage as endpoint rely on valid assessment of the myocardial area at risk (AAR). T2-weighted cardiovascular magnetic resonance (CMR) imaging is the preferred method to assess the AAR. However, T2-weighted imaging can be of poor image quality and uninterpretable. Contrast-enhanced (CE) cine imaging can also show AAR and our aim was to investigate if CE-cine can replace T2-weighted imaging. Cine imaging is part of a standard CMR-protocol and implementing CE-cine imaging for assessment of the AAR would mean shorter investigation time. Methods and results As a DANAMI-3 substudy, we performed successful dual imaging of the AAR in 166 participants using both T2-weighted short tau inversion recovery (T2-STIR) and CE-cine imaging. T2-STIR imaging was non-diagnostic in nine and CE-cine in one scan during the period. CE-cine measured 4.7% of left ventricle (LV) [95% confidence interval 3.2–6.2%] smaller AAR compared with T2-STIR images (P  < 0.001). Visual analysis of a plot of infarct size vs. AAR showed an overestimation of the AAR when measured with T2-STIR images. There was no difference in AAR with CE-cine in an interobserver analysis of 46 scans [1.2 g (standard deviation 9.5), P  = 0.42]. Conclusions CE-cine imaging shows good internal consistency in assessment of the AAR. A visual inspection reveals possible overestimation of AAR with T2-STIR images. There is good interobserver agreement in the analysis of CE-cine imaging. CE-cine can replace T2-STIR imaging resulting in a more valid assessment of the myocardial AAR. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results