31 results on '"Schenowitz, A"'
Search Results
2. La jouissance féminine et le maternel en questions
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Jessica Choukroun-Schenowitz
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Féminin ,maternel ,jouissance ,ravage ,Psychiatry ,RC435-571 - Abstract
L'auteur se propose de confronter les deux champs contigus du féminin et du maternel à partir des considérations freudiennes sur le “continent noir” qu'est la féminité et de la notion de jouissance féminine déployée par Jacques Lacan. A la lumière de la psychopathologie clinique psychanalytique, cet article veut mettre en évidence que si l'Œdipe ne fait pas La femme, le fait du ravage qui en est sa conséquence, envahit aussi bien le féminin que le maternel. En effet, la part de jouissance opaque de la mère, soit le féminin dans la mère, contamine la féminité tout comme la maternité d'une femme, tel qu'en témoigne le rapport de ravage qui peut exister entre une fille et sa mère. Il s'agira ainsi de pointer que, pas plus que le devenir femme, le devenir mère n'est donné d'emblée mais qu'il se construit du rapport au langage, au fantasme, à la jouissance et à l'Autre en la figure de l'amour maternel, pour chaque une.
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- 2022
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3. The HLA-G immune checkpoint: a new immuno-stimulatory role for the α1-domain-deleted isoform
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Tronik-Le Roux, Diana, Daouya, Marina, Jacquier, Alix, Schenowitz, Chantal, Desgrandchamps, François, Rouas-Freiss, Nathalie, and Carosella, Edgardo D.
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- 2022
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4. Transmission universitaire en référence à la psychanalyse
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Chiantaretto, Jean-François, primary and Choukroun-Schenowitz, Jessica, additional
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- 2021
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5. Cord blood-endothelial colony forming cells are immunotolerated and participate at post-ischemic angiogenesis in an original dorsal chamber immunocompetent mouse model
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Richard Proust, Anne-Charlotte Ponsen, Valérie Rouffiac, Chantal Schenowitz, Florent Montespan, Karine Ser-Le Roux, Frédéric De Leeuw, Corinne Laplace-Builhé, Philippe Mauduit, Edgardo D. Carosella, Sébastien Banzet, Jean-Jacques Lataillade, Nathalie Rouas-Freiss, Georges Uzan, and Juliette Peltzer
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Endothelial progenitor cells ,Cord blood-endothelial colony forming cells ,Immunotolerance ,Ischemia ,Angiogenesis ,Medicine (General) ,R5-920 ,Biochemistry ,QD415-436 - Abstract
Abstract Background Cardiovascular diseases are the main cause of morbidity and mortality worldwide. Restoring blood supply to ischemic tissues is an essential goal for the successful treatment of these diseases. Growth factor or gene therapy efficacy remains controversial, but stem cell transplantation is emerging as an interesting approach to stimulate angiogenesis. Among the different stem cell populations, cord blood-endothelial progenitor cells (CB-EPCs) and more particularly cord blood-endothelial progenitor cell-derived endothelial colony forming cells (CB-ECFCs) have a great proliferative potential without exhibiting signs of senescence. Even if it was already described that CB-ECFCs were able to restore blood perfusion in hind-limb ischemia in an immunodeficient mouse model, until now, the immunogenic potential of allogenic CB-ECFCs remains controversial. Therefore, our objectives were to evaluate the immune tolerance potency of CB-ECFCs and their capacity to restore a functional vascular network under ischemic condition in immunocompetent mice. Methods In vitro, the expression and secretion of immunoregulatory markers (HLA-G, IL-10, and TGF-β1) were evaluated on CB-ECFCs. Moreover, CB-ECFCs were co-cultured with activated peripheral blood mononuclear cells (PBMCs) for 6 days. PBMC proliferation was evaluated by [3H]-thymidine incorporation on the last 18 h. In vivo, CB-ECFCs were administered in the spleen and muscle of immunocompetent mice. Tissues were collected at day 14 after surgery. Finally, CB-ECFCs were injected intradermally in C57BL/6JRj mice close to ischemic macrovessel induced by thermal cauterization. Mice recovered until day 5 and were imaged, twice a week until day 30. Results Firstly, we demonstrated that CB-ECFCs expressed HLA-G, IL-10, and TGF-β1 and secreted IL-10 and TGF-β1 and that they could display immunosuppressive properties in vitro. Secondly, we showed that CB-ECFCs could be tolerated until 14 days in immunocompetent mice. Thirdly, we revealed in an original ischemic model of dorsal chamber that CB-ECFCs were integrated in a new functional vascular network. Conclusion These results open up new perspectives about using CB-ECFCs as an allogeneic cell therapy product and gives new impulse to the treatment of cardiovascular diseases.
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- 2020
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6. Cord blood-endothelial colony forming cells are immunotolerated and participate at post-ischemic angiogenesis in an original dorsal chamber immunocompetent mouse model
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Proust, Richard, Ponsen, Anne-Charlotte, Rouffiac, Valérie, Schenowitz, Chantal, Montespan, Florent, Ser-Le Roux, Karine, De Leeuw, Frédéric, Laplace-Builhé, Corinne, Mauduit, Philippe, Carosella, Edgardo D., Banzet, Sébastien, Lataillade, Jean-Jacques, Rouas-Freiss, Nathalie, Uzan, Georges, and Peltzer, Juliette
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- 2020
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7. Human Keratinocytes Inhibit CD4+ T-Cell Proliferation through TGFB1 Secretion and Surface Expression of HLA-G1 and PD-L1 Immune Checkpoints
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Guillaume Mestrallet, Frédéric Auvré, Chantal Schenowitz, Edgardo D. Carosella, Joel LeMaoult, Michèle T. Martin, Nathalie Rouas-Freiss, and Nicolas O. Fortunel
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skin immunity ,human keratinocytes ,immunomodulation ,HLA-G1 ,PD-L1 ,TGFB1 ,Cytology ,QH573-671 - Abstract
Human skin protects the body against infection and injury. This protection involves immune and epithelial cells, but their interactions remain largely unknown. Here, we show that cultured epidermal keratinocytes inhibit allogenic CD4+ T-cell proliferation under both normal and inflammatory conditions. Inhibition occurs through the secretion of soluble factors, including TGFB1 and the cell-surface expression of HLA-G1 and PD-L1 immune checkpoints. For the first time, we here describe the expression of the HLA-G1 protein in healthy human skin and its role in keratinocyte-driven tissue immunomodulation. The overexpression of HLA-G1 with an inducible vector increased the immunosuppressive properties of keratinocytes, opening up perspectives for their use in allogeneic settings for cell therapy.
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- 2021
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8. Haine de l’être et radicalisme de l’identitaire : la honte et le problème du corps de l’Autre
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Jessica Choukroun-Schenowitz
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- 2022
9. Fragmentação do corpo e cirurgia bariátrica. Do orgânico ao corpóreo em sua relação com a lógica estrutural
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Charlotte Collet, Jessica Choukroun-Schenowitz, and Mohammed Ham
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psicosis ,neurosis ,psicose ,bariatric surgery ,fragmentación del cuerpo ,Cuerpo ,névrose ,chirurgie bariatrique ,Corpo ,psychose ,Psychiatry and Mental health ,Clinical Psychology ,Corps ,cirugía bariátrica ,cirurgia bariátrica ,Body ,psychosis ,fragmentação do corpo ,neurose ,morcellement corporel ,body fragmentation - Abstract
Les auteurs, cliniciens et chercheurs en psychopathologie, développent un phénomène psychique transtructurel rencontré chez des patients obèses opérés d’une chirurgie bariatrique: des fantasmes et des délires de morcellement corporel. C’est à partir d’un cas clinique de névrose et un autre de psychose, que l’impact psychique de la chirurgie bariatrique sera étudié, avec la mise en lumière d’une altération de l’image du corps et de ses sensations qui serait à l’origine de ce phénomène de morcellement. The authors, clinicians, and researchers in psychopathology, developed a trans-structural psychic phenomenon found in obese patients who have undergone bariatric surgery: fantasies and delusions of body fragmentation. The psychic impact of bariatric surgery was studied based on a clinical case of neurosis and another one of psychosis, highlighting an alteration of body image and its sensations which would be at the origin of this phenomenon of fragmentation. Resumos Os autores, clínicos e pesquisadores em psicopatologia, desenvolvem um fenômeno psíquico transestrutural encontrado em pacientes obesos submetidos à cirurgia bariátrica: fantasias e delírios de fragmentação do corpo. Com base em um caso clínico de neurose e outro de psicose, será estudado o impacto psíquico da cirurgia bariátrica, destacando uma alteração na imagem do corpo e suas sensações, que estariam na origem desse fenômeno de fragmentação. Los autores, clínicos e investigadores en el campo de la psicopatología, desarrollan un fenómeno psíquico transestructural encontrado en pacientes obesos sometidos a la cirugía bariátrica: fantasías y delirios de fragmentación del cuerpo. Desde un caso clínico de neurosis y otro de psicosis, se estudiará el impacto psíquico de la cirugía bariátrica, destacando una alteración de la imagen corporal y de sus sensaciones, que serían el origen de este fenómeno de fragmentación.
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- 2022
10. Haine de l’être et radicalisme de l’identitaire : la honte et le problème du corps de l’Autre
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Choukroun-Schenowitz, Jessica, primary
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- 2022
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11. Morcellement du corps et chirurgie bariatrique. De l’organique au corporel dans leur rapport aux logiques structrurelles
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Collet, Charlotte, primary, Choukroun-Schenowitz, Jessica, additional, and Ham, Mohammed, additional
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- 2022
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12. The HLA-G immune checkpoint: a new immuno-stimulatory role for the α1-domain-deleted isoform
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Diana Tronik-Le Roux, Marina Daouya, Alix Jacquier, Chantal Schenowitz, François Desgrandchamps, Nathalie Rouas-Freiss, and Edgardo D. Carosella
- Subjects
HLA-G Antigens ,Pharmacology ,Cellular and Molecular Neuroscience ,Cell Membrane ,Humans ,Protein Isoforms ,Molecular Medicine ,Cell Biology ,Carcinoma, Renal Cell ,Molecular Biology ,Kidney Neoplasms - Abstract
The heterogeneity of cancer cells, in part maintained via the expression of multiple isoforms, introduces significant challenges in designing effective therapeutic approaches. In this regard, isoforms of the immune checkpoint HLA-G have been found in most of the tumors analyzed, such as ccRCC, the most common human renal malignancy. In particular, HLA-G∆α1, which is the only HLA-G isoform described that lacks the α1 extracellular domain, has been newly identified in ccRCC and now here in trophoblasts. Using a cellular model expressing HLA-G∆α1, we have uncovered its specific and overlapping functional roles, relative to the main HLA-G isoform, i.e., the full-length HLA-G1. We found that HLA-G∆α1 has several particular features: (i) although possessing the α3 domain, it does not associate with β2-microglobulin; (ii) it may not present peptides to T cells due to absence of the peptide-binding groove; and (iii) it exerts immune-stimulatory activity towards peripheral blood NK and T cells, while all known isoforms of HLA-G are immune-inhibitory checkpoint molecules. Such immune-stimulatory properties of HLA-G∆α1 on the cytotoxic function of peripheral blood NK cells are individual dependent and are not exerted through the interaction with the known HLA-G receptor, ILT2. Importantly, we are faced here with a potential antitumor effect of an HLA-G isoform, opposed to the pro-tumor properties described for all other HLA-G isoforms, which should be taken into account in future therapeutic designs aimed at blocking this immune checkpoint.
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- 2022
13. La jouissance féminine et le maternel en questions
- Author
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Choukroun-Schenowitz, Jessica, primary
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- 2021
- Full Text
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14. Transmission universitaire en référence à la psychanalyse
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Jessica Choukroun-Schenowitz and Jean-François Chiantaretto
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- 2021
15. Human Keratinocytes Inhibit CD4+ T-Cell Proliferation through TGFB1 Secretion and Surface Expression of HLA-G1 and PD-L1 Immune Checkpoints
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Mestrallet, Guillaume, primary, Auvré, Frédéric, additional, Schenowitz, Chantal, additional, Carosella, Edgardo D., additional, LeMaoult, Joel, additional, Martin, Michèle T., additional, Rouas-Freiss, Nathalie, additional, and Fortunel, Nicolas O., additional
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- 2021
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16. Prevalence of diabetic and impact on cardiovascular events and mortality in patients with chronic coronary syndromes, across multiple geographical regions and ethnicities
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H Appeltants, C Boesch, I Cromarty, D Carretta, S Romanov, U Windstetter, F Mibach, Jens Refsgaard, S Lebedev, F Proietti, M Y Tamimi, M C Gamboa, M Novikova, E Prada, K H Sim, E Messas, E Zherlitsyna, A Kalampalikis, N Nevolina, N Trocan, J Cohen, G Szto, R Gilabert Gómez, M Omelchenko, A Pinzani, D Goodwin, J Umaran Sánchez, Kim Fox, S H Dong, K Kronberg, E Castillo Lueña, T Ignatieva, S Joubert, C Macchi, S Lee, S Eidelman, F Alizon, S Chandra, M Akbar, D M Colquhoun, G Yanes Bowden, J de Juan Baguda, M Sebastian, C Wernham, K Miedema, R La Greca, C Morton, B S Jheeta, A C Tran, T Q Do, O Rodrigues, J Yan, S H Kim, R Jurgaitienė, Jean-Claude Tardif, R Baleón, D Hay, V Hennebelle, F Fazekas, R Davies, P Gratia, L Sorodoc, S Y Wu, C Martínez Sánchez, L Lopes Antunes, T H T Pham, I Suliman, M J Gómez Martinez, A Pernat, S H Hur, M Alanazy, L Zhabina, M Stanley, J Rogers, Y J Kim, S Geffroy, L K Andersen, S Coman, V Pedrosa del Moral, Y Garaud, J Krupicka, O Dzhkha, C Paul, M Jeżewska, B Mahler Mioto, V Abduvalieva, P Morra, L Kucheryava, C La Rosa, B Chan, M Wrębiak-Trznadel, A Kozlowski, M Sharif, L López Barreiro, V Kolesnikov, M Lawrence, A Tucker, C Okawabata, B La Hay, E Sadauskienė, B K Nguyen, L Bui, A Said, M E Ruíz Esparza, R K Saran, M S C Ho, E Homs Espinach, J R Romo Santana, J Forte De Carvalho, I Pattison, H H Phan, L Baleeva, L Kisiel, A López Granados, C Raters, F Paganelli, R Haberl, A P T Wong, D Xu, R Jagathesan, L Grekhova, H Stursova, Q B Truong, P Raymond, Y Sosnova, N H Khong, J Zarauza Navarro, C Florescu, L Gorshkova, N Saaidin, E Gordillo Higuero, L Davin, I Budanova, C Lavicka, L Gruznykh, P Bogdański, A Dufka, I Arroja, H A R Tahir, G Wilson, G Kolios, S J Yoon, Simon Cattan, K Berdnik, A Serrano, B Sievers, A Rodríguez Almodóvar, L A Holden, F O'Reilly, D Verleyen, H Hafez, K Nehrig, S M Kang, S Berrisch-Rahmel, E Meyer-Michael, P Samama, L Soares, A K Nguyen, F Tuktarova, C Weytjens, E Sandoval Rodriguez, J Cheng, F M Villasenor, João Morais, B Sullivan, R Zimoląg, Albert V. Smith, S F Ding, J C Louchart, G Guardigli, R Furtak, P Azzolini, S Chushak, J L Delgado Prieto, S Kornienko, K K Sia, J H Shin, F Baylac Domengetroy, P Błaszczak, M Saade, N Černič-Šuligoj, K Coetzee, A Kadleckova, V Scollo, O Larina, R Pal, M M Singh, N Nosova, R Burns, B S Yoo, O Gukov, F Massari, V Antia, A Brattström, G Holt, M Scherbak, V Firastrau, Y J Li, E Mikhailova, L Machado Cesar, C García García, J Pjontek, C Everton Biglow, G Pes, C Brown, A Bumbu, S Felis, R Bosch, M Lazaro, Luigi Tavazzi, R Engel, I Romeo Castillejo, Y S Byun, F Matias, I Grushetskaya, C Mestre-Fernandes, T Kheliya, S Schlesingerova, G Theodorakis, I Tsamopoulos, R Pedretti, A Puente Barragán, M P Vo, B Lammens, T Carruthers, J S Bhatt, A Khodanov, N Pasechnaya, I Petrova, G Boutros, I A Khan, E Le Moal, D Garofalo, H R Malaterre, A Bahal, J F Martínez González, H N Dinh, N V Pham, C Barjhoux, I Gilmour, C Soriano Navarro, O D Chioncel, K Tóth, N Borodina, P Khanoyan, B Sevilla Toral, H H Kim, C M A Bui, C Dernedde, N Eliseeva, M Galinier, E Kosachek, M M Doohan, L Potapska, M Tennekoon, R Nourallah, L Perez De Isla, K H Chee, E Panova, D M Walker, G Glanowska, G Hua, A Silvestre, W Wang, Matthew A. Brown, B Luke, G Jarosiński, R Davis, S Cleron, C Liatas, I Orestis, M Dereń, J Sudnik, S X Zhou, J Fuertes Alonso, O Baranova, S Mingalaeva, T N Vo, K A Ngo, J A Rodríguez Fernández, R Ishmael, G Bode, K K Chan, G Al Radaideh, S Ramphall, H D Theron, V Montagud Saavedra, A Yusuf, G F Mazzanti Mignaqui, L Evtukhova, J Lorenc, D Beacock, O B Šlapikienė, F Alitto, J N Poujois, B Berzal Martín, M Felbermayer, V Mallamaci, T Spitsina, R Ramachandran, A Jánosi, V Dženkevičiūtė, S Gillam, V Joulie, G Esna Ashari, R Henry, E Durand, A Alam, V Fourchard, H Dreycopp, R Fressonnet, C Camossa, O Jerzykowska, M Castrucci, G Sinicropi, B K Goyal, V Vasylenko, R Grogono, M Partington, B Vaquette, R Blindt, Mª T Moreno Casquete, V Kukaleva, W Streb, P F Clavette, M Pérez Paredes, V Hadjiivanov, C Bundy, D E Manyari, A Wassef, J Kuchar, W Nisker, P S Bath, S Panpunnung, G H Choo, Datshana P Naidoo, Y Pavlova, R McManus, N Brand, E Davies, L Prunier, A Schenowitz, P Sternthal, T Sinotova, J Martínez Florez, R Sykulski, J Pinar Sopena, M Balbi, Y Pesant, D A Playford, C Villar Mariscal, F Redding Escalante, W Wongcharoen, O Grechishkina, A Girão, M Speth-Nitschke, K A Mahendran, A Bianco, A Vadavi, G Singh, L Petoin Peuch, L Sukhanova, A Y Y Fong, J L Vega Barbado, A Dzien, S Honorat, G Ansalone, G Kamensky, G McLaren, T B Kim, I Bratu, R Fillet, V Rogozhyna, L Nagy, M Malgina, M A Sheikh Abdul Kader, Z C Li, L Rotaru H Rus, D Adamczyk-Kot, J Estrella, S Serrano García, P Farto E Abreu, D Mescharekova, Su Thillai Vallal, P Seal, S Möller, A Cziráki, T T H Ta, S Davies, H Ge, M Arafah, M Ovize, A Olszewski, V Aboyans, C Roche, F Al Tamimi, L Popova, V Kazachkova, R Rennert, J Aubry, G Bourgeois, J Mackrell, F Al Kandari, N Reifart, J Bérubé, W H J Hutse, O Lysunets, I Butkuvienė, J Cotroneo, J Gdalia, J Dalle Mule, R Santos, B Singh, H Mohammed, A Birkenhagen, T Chiscaneanu, H Sullivan, Jacob A. Udell, N Bolotova, A Jankowska, M Skonieczny, B S K Ch'ng, O Aiyegbayo, S Ciaroni, N Lago, S R Coimbra, R Ellis, B K Koo, S Rostik, P Jacquier, A Conradie, N Biryukova, M Ayche, A Khripun, B Peperstraete, E Velasco Espejo-Saavedra, G Cunliffe, G Grollier, C Ceraulo, T L To, Q H Tran, M Anscombe, R Jordan, I Czuriga, P Haimes, R Ancín Viguiristi, H Q Zhang, C A Chételat, A Rafter, E Rinkūnienė, K Yang, W Gao, J Pearce, L C Fernández Léoz, L Gareeva, R Fernández Alvarez, G Verret, P Astrakhantseva, C M Chu, L Murphy, P A Do, J L Liu, A Clifford, K Woollard, N Dmitrieva, N Lousada, R Díaz Juárez, N Semenova, T Fesenko, F Henschel, R Amini, G Matuszewska, R Christodorescu, J Varaldi, S Varughese, V Lafarenko, A Ashford, J L Colomer Martín, S Assouline, H Noor Hasni, A Weatherup, T Forster, R Kaserbacher, I Caldwell, N Arabadzhi, Emmanuel Sorbets, A Rink, E C Rueda Calle, J M Stordeur, P West, V C Do, Béla Merkely, J Antunes, U Altmann, S Magheru, B Bachmann, W Parkar, M de los Reyes López, M Wazana, A Frattola, M Mospan, V Koval, E Giusti Rossi, J Vasconcelos, K B Do, A Ogorodnichuk, D Lighezan, G Mentz, J M Cherry, P Pouderou, M Moretti, C M Spinu, Emmanuelle Vidal-Petiot, N Kupstytė, P Jourdain, V Voronina, O Varezhnikova, S Williams, H AlFaleh, R Lew, P Hildebrant, J Drozd, G Muscio, T H Ashton, A Achilli, J Harinasuta, T Ghose, G Walawski, Y Arkhipova, M Alves Costa, B Day, A Suntinger, A Singh, P Sheringham, A Vázquez García, J Taggeselle, J T Dong, T H Goh, G Rojas, R Schultz, A Ballet, O Likhobabina, Z M Qian, S Sandoval Navarrete, D Manzi, S Langridge, W Haerer, C K Abdullah, L Hay, Á Herdade, A Gałuszka-Bilińska, F Biausque, V M Lai, D S Eccleston, L Nikolaeva, P Kalaras, J Martínez Redding, N P H Tran, B Wauer, Philippe Gabriel Steg, B Etcheverry, J Navarro Manchón, R Augarde, C Dixon, M Y Chen, J L Gleizes, S Pustovit, J L Farges, S Cox, G Manchet, K Shein, L Parker, C C Ang, O Sinyukova, V Veth, A Kurekhyan, N Cindea Nica, N Wittlich, J Al Yazeedi, A Pucheu, V Elliott, J Bories, K Alford, M F Ferrão E Vasconcelos, A Adamkiewicz-Piejko, R Cervenak, J F Beltrame, A Castro, L Safonova, G Koutsimpanis, C de Brito Vianna, R Wysocki, V Ginzburg, J Hernández Afonso, A Ihonor, O Golubeva, M Karachaliou, S Kleta, D d'Este, Gustavs Latkovskis, F Jäger, E Gamzatov, Y Kozhelenko, J Lippai, T T L Ong, S J Ge, A Hersi, K Kyd, S Mingam, V Yordanova, L Bardachenko, E Mozerova, S W Liu, J Zdrojewska, E Chung, M Leclair, M Nazir, S Zarechnova, A Rahman, M Sołtysiak, B Maguire, F Moreira Pinto, R Fathi, E Prieto Moriche, C Priftis, P Heno, N Sytilina, A Pladys, S Shimonenko, P Keller, J F Junior, G Amiel Oster Sauvinet, J P Kanner, L Tkachenko, J Dalal, A Liston, D Herrera Fernández, J L Bonnet, A Chirivella González, R P Shah, F A Reyes Cisneros, C Avgerinos, P Ravoala, V Albero Martínez, G Suarez, V Jouve, A Frankiewicz, A Lindsay, A De Meester, H Dau, M Pornin, J Álvarez Gil, J Murin, T Hodac, J J Gómez Barrado, Y J Wu, S Jean, P Hilti, A Dayani, R Steponėnienė, G A Somsen, H Zhang, J Moore, P Tarenidis, T H Nguyen, M Maliszewski, L Voloshyna, S Novo, A Phrommintikul, I Shanina, Roberto Ferrari, P Franklin, C Turner, W Boonyapisit, F Sepulcri, P Vandergoten, J Carvalho, J Halcox, V Rotenberger, J F Baril, M Turiel, P Shiels, P Painsipp, S Reis Monteiro, T Honsig, V Vivekaphirat, J Ardill, P Brodzicki, A Khalifa, H Audibert, T Wettstein, F Auhser, D Ezekiel, D Pella, E Simarro Martín-Ambrioso, H S Seo, J A Núñez Gamero, Gabriel Steg, M Orbán, S Bykovskaya, W Gadziński, N Rozkova, G H M Vawda, R A Motyer, B Limeres González, E Fernandez Valadez, Riyaz S. Patel, I Shaikh, E Ziak, A Estriga, P Dodemant, Dragos Vinereanu, W Miao, L Marullo, F MacNamara, S K Tan, N Giacomantonio, A Leherissier, H W Li, Arpana Agrawal, Y Moreau, F David, S K Ma, A N Jamaluddin, E Alegría Ezquerra, Scalzo, M C Ta, T T Nguyen, A Sudre, R Gupta, H Lagioia, M Haiba, P Kohan, M Szentivanyi, T Dmitrieva, N Vechtomova, C Vuille, R G Schena, P Navratil, O Tsygankov, L Saaby, P Lefebvre, S King Wong, S Maheas Morlet, N H Pham, P Bonnet, S Modi, L Gaspar, M Karlicek, S Pallie, H T Pham, S Abele, N Bizyaeva, L Facila Rubio, N Meneveau, G Poluyanova, J Calaça, S Orazi, M Emonts, A Yusufali, V Sprott, Z Vazhdaeva, M R Conte, E Bulakhova, K Giokoglu, E Page, E Kotova, G Maragoni, C Jerjes Sánchez, T Kiver, M Brunehaut Petaut, A Nagy, P Singer, Zs Sziegl, B Fontanet, S Strange, A Watson, J Föchterle, Janet A. Dunn, R Šlapikas, M Stikhurova, S Salimova, J Volmar, E Otero Chulian, S Hutchinson, R Koller, X Bonnaud, E Peris Domingo, F Marín Ortuño, E Galve Basilio, S Bongo, L Payot, C Miller, A Samothrakitis, L Silva Melchor, K Orzechowski, W Hofer, L V Nguyen, R Oliver, K T Jung, J Robb, D Sobczyk, J Muller, A Tomatti, M Gruchała, C Bradshaw, D Richmond, E Mineeva, E Smirnova, A Idrissi-Sbai, H Vial, R Balai, I Kiseleva, H Jones, M Gibbs, D Ohlmeyer, Y Al Wahshi, V d’Alessandro, S Pérez Ibiricu, V Zachos, A Chernozemova, D R Spink, J Schneider, A M Peset Cubero, M Irurita Latasa, M Migliore, G Perna, E Daniels, M H Tay, N Z Khiew, I Soin, F Bernasconi, T Garban, F Omardeen, O Rodina, L Kanagaratnam, I Blum-Decary, A Jaussi, D Romero Alvira, D Vermander, N Kanumilli, M A Romero Maldonado, M Fernández-Valls Gómez, H Tran, T P Nguyen, H Omar, R S Collette, B Kisjós, H Krause-Allmendinger, J Silva E Sá, H Topf, F Panetta, T C Do, G Roul, J Leso, A Lacroix, M Fic, C Hart, R Chan, L Lema, Y Polyanskaya, R Howlett, Lesley J. 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M Baar, P Lafontaine, C O'Dong, I Petropoulos, B-M Altevogt, D Warden, T De Backer, G Miñana Escrivá, T L Mai, U Schlesinger-Irsch, M M Gomaa, E Moksyuta, M Drexler, P Monteiro, P Grooterhorst, J Moolman, P McAlavey, J O'Shea, L P Quinn, F Crespo, K Srinivasa Reddy, T Shokina, Ellen M. Schmidt, M H Jeong, K Denef, A Pleskof, I Takács, Y Tikhonov, O Ushakov, L Stevens, J Ezcurdia Sasieta, L Nkombua, O Henne Otero, J Y Fraboulet, D S Kim, G Hoh, A Tamm, M Sardon, G Chatzioakim, M A Ulecia Martínez, S Reymond, M Myint, G Proença, R Massabie, E Foster, H Dougall, Anjan Kumar Roy, C Franco Aranda, M Getman, E Filippova, C Aguiar, X D Pu, N Voronina, L L Chen, M Szulc, L Bayakhchan, M J Pinto Vaz, C Niederberger, N Vites, I Sen, Paul R. Kalra, J A Castillo Moreno, W K Ng, C Brunschwig, D Morgan, A Concepción Clemente, N Yakimova, J M Guy, A H Jaafar, J Badarienė, N Taylor, L Compson, R Amor, A Maximovitch, J L Bardají Mayor, E Marín Araez, N H Chau, N Srtumilenko, K Kelly, A Papathanasioy, S Erofeev, B Mamez, A Ribeiro, M Micko, N Alvarenga Recalde, K Atueva, Z Sebõk, P Kycina, A K Gupta, A Laucevičius, R Ahuja, A Prokop, P Stadler, S De Ridder, L Zhang, F B Ramadan, L Kapustina, V Fedoskin, A Bateman, C A Nacht, R Musetescu, M Aparici Feal, A Büttl, S Ross, M Rau, P Federico Zaragoza, G Brisson, M Zagreanu, T T H Pham, F Dominé, N Davydova, N Petrochenko, N Paul, P H Truong, S Frickel, W Bryl, G Brouillette, A Stumpp, M Barrera Bustillos, C Ziccarelli, O Zalyzniak, M eatherhead, N Watkins, G Riccioni, l Kudryavtsev, R Carvalho, J P S Sawhney, V González Toda, P Matos Dias, M Giorgadze, I Rodriguez Marrero, W Gritsch, K Lee, G W Kellam, I Parker, V Ecina, Mª I Soto Ruiz, C Delhomme, T Ivaschenko, Y W Cheah, I Grudtsina, R Chehayeb, T Dookie, O Krasnoslobodskaya, P Jarmużek, F Van den Branden, A M F Vandeplas, A Rocha De Almeida, M Espiga De Macedo, E Łotocka, K Nagy, R Paliulionienė, J L Leyva Pons, N Fedorova, Y Yanina, O Stasuk, Z Vlasuk, P Lim, P Egloff, T Berezhna, A Faria, J Cerda Rojas, E Moser, H G Jin, S J Oh, G Arquero García, K H Karner, I Leontaridis, A Banikova, J Fridrich, H Lesseliers, I Pokrovskaya, P Astridge, H Abdul Manap, R Daniel, C A Almeida Fernández, A Nowowiejska-Wiewióra, B Carvalho De Moura, M Malden, H Rosenstein, S Dixon, G Balogh, M Adam-Blanpain, A Sandalian, H Gervas Pavón, G A Antoniadis, N Naberezhnova, A Amlaiky, P Terrosu, K K H Lau, B Chartier, X Su, O Kovyrshyna, G Beale, P Primot, M H Chen, S S Ramesh, R Chyrek, E Gómez Álvarez, J Rodríguez Collado, G Sibilio, R Jeremiasz, R Colin, C Lalla, G M Fullerton, M P Samal, H Thümmel, R P Patel, J Takhar, H M Kwon, T A Cieza Lara, F Magliari, J Morrell, M Rayo Gutiérrez, T L Orenstein-Lyall, H Choi, S Kulinich, A Aftab, A Wallace, B B Abdul Kareem, S Kwok, A Królak, A Grover, Laurent Fauchier, Mª J Pinilla Lozano, G Sengupta, D Paris, M Al Dhanki, J Milewski, F Petersen Aranguren, H Brufau Redondo, H Mayr, A Arias Mendoza, M Ducoudre, A Correia, J S Awtar Singh, P Aylward, E Brscic, J Du Plooy, J L Arenas León, G Silva Alves, L Sreenivasa Murthy, P Dendale, F La Varra, S Minkin, T Eggeling, A Jamiel, G Lebischak, E Andreev, T V A Tuong, V Chaithiraphan, O Duprez, S Higgins, F Chometon, Y Cottin, A Bonny, C Guyetand, J Matos, F Henpin Yue Cesena, L Polyaeva, M Drijfhout, J Toplak, G E Vertes, N F Wang, J Doucet, A K Trivedi, P Turek, G Chouinard, A Al Lawati, W Filip, F Kovar, T J Cha, A Belanger, H L Cong, J F Robert, D López Gómez, J L Sanz Rodríguez, H Simper, P Shetty, A Chukwu, E Bukanina, C Amoros Galito, H MacCowan, T T T Tran, A Singal, K C Vu, O Ismail, A Ardiaca Capell, P Bousquet, F Goss, Z Galeeva, Maxime Guenoun, B Rijavec, Z Lazerevic, A McCracken, A C Motoc, Y Sharapova, S Wright, A J Paule Sánchez, L Mainar Latorre, I Sirazov, X L Yang, S E Paget, G Berkenboom, J Markenvard, I Surovtseva, S K George, Matthias Simon, M L Fuantos Delgado, C Christoforidis, M Lagares Carballo, P Alvarez García, J Könemann, L Crawford, I Gonos, D Saulnier, E Szabó, L Ardouin, J Bhayat, F J Abardía Oliva, X Bernard, O Sirbu, P Boutsikos, N Khmelevskikh, E Tavlueva, P LeBouthillier, I Bourazanis, A Sequeira, M López Martínez, C P Paulus, R K M Bhaskaran, F Pellerin, B Brown, B Saleh, A Lacchè, R Sola Casado, E Kaźmierczak, M Weingrod, and G Vijayaraghavan
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medicine.medical_specialty ,Cardiac & Cardiovascular Systems ,Epidemiology ,LONG-TERM ,medicine.medical_treatment ,Chronic coronary syndromes ,Coronary Artery Disease ,Revascularization ,Ventricular Function, Left ,GLUCOSE ,MELLITUS ,Risk Factors ,Internal medicine ,Diabetes mellitus ,Diabetes Mellitus ,Ethnicity ,Prevalence ,medicine ,Humans ,ARTERY-DISEASE ,Myocardial infarction ,Stroke ,RISK ,OUTCOMES ,Ejection fraction ,Science & Technology ,business.industry ,Proportional hazards model ,CLARIFY Investigators ,Hazard ratio ,Diabetes ,Stroke Volume ,Geographical disparities ,Syndrome ,medicine.disease ,MIDDLE-EAST ,EUROPEAN-SOCIETY ,Treatment Outcome ,MYOCARDIAL-INFARCTION ,Heart failure ,CLARIFY registry ,Cardiovascular System & Cardiology ,HEART-FAILURE ,Cardiology and Cardiovascular Medicine ,business ,Life Sciences & Biomedicine - Abstract
BackgroundIn contrast with the setting of acute myocardial infarction, there are limited data regarding the impact of diabetes mellitus on clinical outcomes in contemporary cohorts of patients with chronic coronary syndromes. We aimed to investigate the prevalence and prognostic impact of diabetes according to geographical regions and ethnicity.Methods and resultsCLARIFY is an observational registry of patients with chronic coronary syndromes, enrolled across 45 countries in Europe, Asia, America, Middle East, Australia, and Africa in 2009–2010, and followed up yearly for 5 years. Chronic coronary syndromes were defined by ≥1 of the following criteria: prior myocardial infarction, evidence of coronary stenosis >50%, proven symptomatic myocardial ischaemia, or prior revascularization procedure.Among 32 694 patients, 9502 (29%) had diabetes, with a regional prevalence ranging from below 20% in Northern Europe to ∼60% in the Gulf countries. In a multivariable-adjusted Cox proportional hazards model, diabetes was associated with increased risks for the primary outcome (cardiovascular death, myocardial infarction, or stroke) with an adjusted hazard ratio of 1.28 (95% confidence interval 1.18, 1.39) and for all secondary outcomes (all-cause and cardiovascular mortality, myocardial infarction, stroke, heart failure, and coronary revascularization). Differences on outcomes according to geography and ethnicity were modest.ConclusionIn patients with chronic coronary syndromes, diabetes is independently associated with mortality and cardiovascular events, including heart failure, which is not accounted by demographics, prior medical history, left ventricular ejection fraction, or use of secondary prevention medication. This is observed across multiple geographic regions and ethnicities, despite marked disparities in the prevalence of diabetes.ClinicalTrials identifierISRCTN43070564
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- 2021
17. Are the Immune Properties of Mesenchymal Stem Cells from Wharton’s Jelly Maintained during Chondrogenic Differentiation?
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Huselstein, Charlotte Voisin, Ghislaine Cauchois, Loïc Reppel, Caroline Laroye, Laetitia Louarn, Chantal Schenowitz, Paulin Sonon, Isabelle Poras, Valentine Wang, Edgardo D. Carosella, Nadia Benkirane-Jessel, Philippe Moreau, Nathalie Rouas-Freiss, Danièle Bensoussan, and Céline
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mesenchymal stem/stromal cells ,immunomodulation ,cell differentiation ,allogeneic context ,Advanced Therapy Medicinal Product - Abstract
Background: Umbilical mesenchymal stem/stromal cells (MSCs), and especially those derived from Wharton’s jelly (WJ), are a promising engineering tool for tissue repair in an allogeneic context. This is due to their differentiation capacity and immunological properties, like their immunomodulatory potential and paracrine activity. Hence, these cells may be considered an Advanced Therapy Medicinal Product (ATMP). The purpose of this work was to differentiate MSCs from WJ (WJ-MSCs) into chondrocytes using a scaffold and to evaluate, in vitro, the immunomodulatory capacities of WJ-MSCs in an allogeneic and inflammatory context, mimicked by IFN-γ and TNF-α priming during the chondrogenic differentiation. Methods: Scaffolds were made from hydrogel composed by alginate enriched in hyaluronic acid (Alg/HA). Chondrogenic differentiation, immunological function, phenotype expression, but also secreted soluble factors were the different parameters followed during 28 days of culture. Results: During chondrocyte differentiation, even in an allogeneic context, WJ-MSCs remained unable to establish the immunological synapse or to induce T cell alloproliferation. Moreover, interestingly, paracrine activity and functional immunomodulation were maintained during cell differentiation. Conclusion: These results show that WJ-MSCs remained hypoimmunogenic and retained immunomodulatory properties even when they had undergone chondrocyte differentiation.
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- 2020
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18. Are the Immune Properties of Mesenchymal Stem Cells from Wharton’s Jelly Maintained during Chondrogenic Differentiation?
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Voisin, Charlotte, Cauchois, Ghislaine, Reppel, Loïc, Laroye, Caroline, Louarn, Laetitia, Schenowitz, Chantal, Sonon, Paulin, Poras, Isabelle, Wang, Valentine, D. Carosella, Edgardo, Benkirane-Jessel, Nadia, Moreau, Philippe, Rouas-Freiss, Nathalie, Bensoussan, Danièle, Huselstein, Céline, Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Ingénierie, Biologie et Santé en Lorraine (IBSLor), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Unité de Thérapie Cellulaire et Tissulaire [CHU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Institut de Biologie François JACOB (JACOB), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Immunologie humaine, physiopathologie & immunothérapie (HIPI (UMR_S_976 / U976)), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)
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cell differentiation ,lcsh:R ,lcsh:Medicine ,advanced therapy medicinal product ,[SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC] ,mesenchymal stem/stromal cells ,immunomodulation ,[SDV.IB.BIO]Life Sciences [q-bio]/Bioengineering/Biomaterials ,allogeneic context ,ComputingMilieux_MISCELLANEOUS ,Article - Abstract
International audience; Background: Umbilical mesenchymal stem/stromal cells (MSCs), and especially those derived from Wharton’s jelly (WJ), are a promising engineering tool for tissue repair in an allogeneic context. This is due to their differentiation capacity and immunological properties, like their immunomodulatory potential and paracrine activity. Hence, these cells may be considered an Advanced Therapy Medicinal Product (ATMP). The purpose of this work was to differentiate MSCs from WJ (WJ-MSCs) into chondrocytes using a scaffold and to evaluate, in vitro, the immunomodulatory capacities of WJ-MSCs in an allogeneic and inflammatory context, mimicked by IFN-γ and TNF-α priming during the chondrogenic differentiation. Methods: Scaffolds were made from hydrogel composed by alginate enriched in hyaluronic acid (Alg/HA). Chondrogenic differentiation, immunological function, phenotype expression, but also secreted soluble factors were the different parameters followed during 28 days of culture. Results: During chondrocyte differentiation, even in an allogeneic context, WJ-MSCs remained unable to establish the immunological synapse or to induce T cell alloproliferation. Moreover, interestingly, paracrine activity and functional immunomodulation were maintained during cell differentiation. Conclusion: These results show that WJ-MSCs remained hypoimmunogenic and retained immunomodulatory properties even when they had undergone chondrocyte differentiation.
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- 2020
19. Tumor Heterogeneity Uncovered by HLA-G Isoforms Expression
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Jérôme Verine, Edgardo Delfino Carosella, Diana Tronik-Le Roux, Chantal Schenowitz, Nathalie Rouas-Freiss, Raluca Stanciu, Julie Renard, Alix Jacquier, and François Desgrandchamps
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Gene isoform ,Expression (architecture) ,HLA-G ,Cancer research ,Biology ,Tumor heterogeneity - Published
- 2019
20. Mesenchymal Stem Cells Derived from Human Bone Marrow and Adipose Tissue Maintain Their Immunosuppressive Properties After Chondrogenic Differentiation: Role of HLA-G
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Chantal Schenowitz, Wenjing Du, Céline Huselstein, Zhongchao Han, Edgardo D. Carosella, Nathalie Rouas-Freiss, Loïc Reppel, Danièle Bensoussan, Léonore Leger, Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL), Genoscope - Centre national de séquençage [Evry] (GENOSCOPE), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Service de Recherche en Hémato-Immunologie (SRHI - UMR_E 05), Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)
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Cytotoxicity, Immunologic ,0301 basic medicine ,Alginates ,[SDV]Life Sciences [q-bio] ,T-Lymphocytes ,Clinical uses of mesenchymal stem cells ,Adipose tissue ,Bone Marrow Cells ,[SDV.BC]Life Sciences [q-bio]/Cellular Biology ,Biology ,Regenerative medicine ,Antibodies ,Chondrocyte ,Interferon-gamma ,03 medical and health sciences ,Chondrocytes ,Glucuronic Acid ,medicine ,Humans ,Hyaluronic Acid ,ComputingMilieux_MISCELLANEOUS ,Cell Proliferation ,Stem cell transplantation for articular cartilage repair ,HLA-G Antigens ,Immunosuppression Therapy ,Tumor Necrosis Factor-alpha ,Hexuronic Acids ,Mesenchymal stem cell ,Cell Differentiation ,Mesenchymal Stem Cells ,HLA-DR Antigens ,Cell Biology ,Hematology ,3. Good health ,Killer Cells, Natural ,030104 developmental biology ,medicine.anatomical_structure ,Adipose Tissue ,Cellular Microenvironment ,Immunology ,Cancer research ,Bone marrow ,Stem cell ,Chondrogenesis ,Developmental Biology - Abstract
International audience; Mesenchymal stem cells (MSC) have emerged as alternative sources of stem cells for regenerative medicine because of their multipotency and strong immune-regulatory properties. Also, human leukocyte antigen G (HLA-G) is an important mediator of MSC-mediated immunomodulation. However, it is unclear whether MSC retain their immune-privileged potential after differentiation. As promising candidates for cartilage tissue engineering, the immunogenic and immunomodulatory properties of chondro-differentiated MSC (chondro-MSC) require in-depth exploration. In the present study, we used the alginate/hyaluronic acid (Alg/HA) hydrogel scaffold and induced both bone marrow- and adipose tissue-derived MSC into chondrocytes in three-dimensional condition. Then, MSC before and after chondrocyte differentiation were treated or not with interferon γ and tumor necrosis factor α mimicking inflammatory conditions and were compared side by side using flow cytometry, mixed lymphocyte reaction, and immunostaining assays. Results showed that chondro-MSC were hypoimmunogenic and could exert immunosuppression on HLA-mismatched peripheral blood mononuclear cells as well as undifferentiated MSC did. This alloproliferation inhibition mediated by MSC or chondro-MSC was dose dependent. Meanwhile, chondro-MSC exerted inhibition on natural killer cell-mediated cytolysis. Also, we showed that HLA-G expression was upregulated in chondro-MSC under hypoxia context and could be boosted in allogenic settings. Besides, the Alg/HA hydrogel scaffold was hypoimmunogenic and its addition for supporting MSC chondrocyte differentiation did not modify the immune properties of MSC. Finally, considering their chondro-regenerative potential and their retained immunosuppressive capacity, MSC constitute promising allogenic sources of stem cells for cartilage repair.
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- 2016
21. Tumor Heterogeneity Uncovered by HLA-G Isoforms Expression
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Tronik-Le Roux, Diana, primary, Verine, Jérôme, additional, Jacquier, Alix, additional, Stanciu, Raluca, additional, Renard, Julie, additional, Schenowitz, Chantal, additional, Desgrandchamps, François, additional, Rouas-Freiss, Nathalie, additional, and D. Carosella, Edgardo, additional
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- 2019
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22. Traitements du corps, subsistance et désubjectivation
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Jessica Choukroun-Schenowitz
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Subjectification ,Philosophy ,Humanities - Abstract
Cet article se propose d’aborder la question de l’ecriture a partir de la notion de ravage. De Marguerite Duras a Marcela Iacub, il peut se poser la question de l’ecriture du ravage ou de son echec. Comment le traitement du corps et de sa jouissance est-il convoque dans le rapport d’une femme a la question du feminin ? Le ravage peut-il se traiter par l’ecriture ? Peut-il se faire ecriture ? Et peut-on deduire de ces œuvres une accointance entre le feminin et l’ecriture ?
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- 2015
23. Evidence of indirect allorecognition of HLA /non-HLA antigens expressed by bronchial epithelial cells from lung transplant recipients
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Nathalie Rouass-Freiss, Olivier Brugière, Séverine Létuvé, Vincent Bunel, Edgardo D. Carosella, Chantal Schenowitz, and Marina Pretolani
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Cell type ,medicine.anatomical_structure ,Immune system ,Antigen ,Lymphocyte ,Immunology ,Toxoid ,medicine ,Bronchiolitis obliterans ,Human leukocyte antigen ,Biology ,Allorecognition ,medicine.disease - Abstract
Survival after lung transplantation (LTx) remains limited by the occurrence of bronchiolitis obliterans (BO), thought to be a form of chronic rejection. In BO, an indirect allorecognition of both HLA and non-HLA antigens (Ags) expressed by bronchial epithelial cells (BEC) is highly suspected as a crucial trigger for BECs damages, although levels of proof remain weak. We here investigated the indirect allorecognition of Ags expressed by BEC in an original ex-vivo model established from samples of LTx recipients (LTxR). To reproduce the immune crosstalk that may occur in patients, 3 distinct cell types originated from the same LTxR were used: allogenic BECs (graft cells) in primary cultures, monocyte derived dendritic cells (DCs) and peripheral T cells. Mixed lymphocyte reactions were performed between T cells (responding cells) and DCs (stimulating cells) that had been or not previously loaded with Ags such as alloBECs lysates (n=10) or tetanus toxoid (TT) (n=6) as Ag positive control. Four healthy individuals were used as controls with TT-loaded DCs. In LTxR, T-cell proliferation was increased by 49% [16-87%] when DCs loaded with alloBEC lysates were used. TT-loaded DCs increased T-cell proliferation by 51% [9-97]% in controls, but only by 4% [0-76%] in LTxR. These measures were highly variable in both patients and controls. This ex-vivo model allowed us to demonstrate that LTxR display a specific T-cell response against alloBECs Ags through indirect allorecognition mechanism. Further objectives are the ability of this model to early predict BO in LTxR and to gain insight into the respective role of HLA and non-HLA Ags from BECs in alloreactivity.
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- 2016
24. Habitat and taxon as driving forces of carbohydrate catabolism in marine heterotrophic bacteria: example of the model algae-associated bacterium Zobellia galactanivorans Dsij
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Tristan, Barbeyron, François, Thomas, Valérie, Barbe, Hanno, Teeling, Chantal, Schenowitz, Carole, Dossat, Alexander, Goesmann, Catherine, Leblanc, Frank, Oliver Glöckner, Mirjam, Czjzek, Rudolf, Amann, and Gurvan, Michel
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Glycoside Hydrolases ,Polysaccharides ,Carbohydrate Metabolism ,Flavobacteriaceae ,Ecosystem ,Genome, Bacterial ,Polysaccharide-Lyases - Abstract
The marine flavobacterium Zobellia galactanivorans Dsij
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- 2016
25. Habitat and taxon as driving forces of carbohydrate catabolism in marine heterotrophic bacteria: example of the model algae-associated bacterium Zobellia galactanivorans Dsij T
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Barbeyron, Tristan, Thomas, François, Barbe, Valérie, Teeling, Hanno, Schenowitz, Chantal, Dossat, Carole, Goesmann, Alexander, Leblanc, Catherine, Oliver Glöckner, Frank, Czjzek, Mirjam, Amann, Rudolf, Michel, Gurvan, Laboratoire de Biologie Intégrative des Modèles Marins (LBI2M), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Station biologique de Roscoff (SBR), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Genoscope - Centre national de séquençage [Evry] (GENOSCOPE), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Max Planck Institute for Marine Microbiology, Max-Planck-Gesellschaft, Center for Biotechnology (CeBiTec), and Universität Bielefeld = Bielefeld University
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[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology - Abstract
International audience; The marine flavobacterium Zobellia galactanivorans DsijT was isolated from a red alga and by now constitutes a model for studying algal polysaccharide bioconversions. We present an in‐depth analysis of its complete genome and link it to physiological traits. Z. galactanivorans exhibited the highest gene numbers for glycoside hydrolases, polysaccharide lyases and carbohydrate esterases and the second highest sulfatase gene number in a comparison to 125 other marine heterotrophic bacteria (MHB) genomes. Its genome contains 50 polysaccharide utilization loci, 22 of which contain sulfatase genes. Catabolic profiling confirmed a pronounced capacity for using algal polysaccharides and degradation of most polysaccharides could be linked to dedicated genes. Physiological and biochemical tests revealed that Z. galactanivorans stores and recycles glycogen, despite loss of several classic glycogen‐related genes. Similar gene losses were observed in most Flavobacteriia, suggesting presence of an atypical glycogen metabolism in this class. Z. galactanivorans features numerous adaptive traits for algae‐associated life, such as consumption of seaweed exudates, iodine metabolism and methylotrophy, indicating that this bacterium is well equipped to form profitable, stable interactions with macroalgae. Finally, using statistical and clustering analyses of the MHB genomes we show that their carbohydrate catabolism correlates with both taxonomy and habitat.
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- 2016
26. Use of anticoagulants and antiplatelet agents in stable outpatients with coronary artery disease and atrial fibrillation. International CLARIFY registry
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Fauchier, L., Greenlaw, N., Ferrari, R., Ford, I., Fox, K. M., Tardif, J. -C., Tendera, M., Steg, P. G., Sokn, F. J., Reid, C., Lang, I., Van den Branden, F., Cesar, L. M., Mattos, M. A., Nazar Luqman, H., Goudev, A., Dorian, P., Hu, D., Widimsky, P., Hassager, C., Danchin, N., Kaab, S., Vardas, P., Sulaiman, K. J., Al Mahmeed, W., Al Suwaidi, J., Al Rashdan, I., Abdulkader, F., Merkely, B., Kaul, U., Daly, K., Tavazzi, L., Jang, Y., Erglis, A., Laucevicius, A., Jamaluddin, A. N., Gamba, M. A., Tulevski, I. I., Stepinska, J., Morais, J., Macarie, C., Oganov, R., Shalnova, S., Al-Zaibag, M., Hou, M. K., Kamensky, G., Fras, Z., Kanic, V., Naidoo, D. P., Zamorano, J. L., Rickli, H., Jaussi, A., Sriratanasathavorn, C., Kalra, P., Lutai, M., Oleksandr, Nguyen, L. V., Henry, R., Ahuad Guerrero, A., Basara, M., Belcastro, F., Bertarini, J. A., Cazenave, C., Dreycopp, H., Egido, J., Estrella, J., Garofalo, D., Giordano, J., Lagioia, H., Lago, N., La Greca, R., Lema, L., Lopez Cabanillas, N., Luquez, H., Miller, C., Prada, E., Rodenas, P., Schena, R. G., Suarez, G., Tomatti, A., Colquhoun, D. M., Conradie, A., Cox, S., Cross, D., Fathi, R., Fitzgerald, B., Hamilton-Craig, I., Holt, G., Jayasinghe, S. R., Mai, N., Moolman, J., Motyer, R. A., Phillips, K., Rafter, A., Rahman, A., Rainbird, A., Scalia, G., Taylor, A., West, P., Alford, K., Amor, R., Astridge, P., Bastian, B., Bates, F., Doohan, M. M., Du Plooy, J., Ford, J. C., Kanagaratnam, L., Khoury, V., Parkin, R., Rogers, J., Sceats, G., Waldman, A., Wang, D., Wright, S., Ardill, J., Aylward, P., Beltrame, J. F., Bradley, J., Heddle, W., Joseph, M., Rajendran, S., Varughese, S., Brice, E., Hockings, B., Janssen, J., Kozlowski, A., O'Shea, J., Playford, D. A., Woollard, K., Ajani, A., Barron, G., Better, N., Chan, B., Chan, R., Cotroneo, J., Counsell, J. T., Eccleston, D. S., Forge, B. H. R., Hamer, A., Horrigan, M., Jelinek, V. M. J., Lew, R., O'Donnell, D., Panetta, F., Sebastian, M., Soward, A., Srivastava, P., Strathmore, N. F., Sylivris, S., Szto, G., Veth, V., Yip, T., Badr-Eslam, R., Kleemann, L., Steurer, G., Morz-Proszowski, B., Auhser, F., Teleky, U., Sepp, G., Beinhauer, A., Kero, D., Lavicka, C., Perger, T., Hadjiivanov, V., Feldner-Busztin, M., Mika, R., Filip, W., Mahr, A., Toplak, J., Millauer, M. G., Haralambus, P., Walcher, K., Karner, K. 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S., Razzaq, N., O'Toole, O., Rowe, P., Williams, H., Allcock, A., Tucker, A., Sprott, V., Kyd, K., Cunliffe, G., Arden, C., Bateman, A., Kassianos, G., Sinclair, D., Turner, C., Jagathesan, R., Sattar, F., Ashford, A., Chukwu, A., Taylor, H., Pradhan, R., Rundell, T., Howlett, R., Bietzk, R., Myint, M., Partington, M., O'Reilly, F., Baverstock, M., Dixon, S., Tennekoon, M., Brand, N., Haimes, P., Keller, P., Whetstone, S., Kovyrshyna, O., Rogozhyna, V., Kiver, T., Vasylenko, V., Kucheryava, L., Salimova, S., Alekseenko, V., Gukov, O., Myhailiv, I., Kardashevskaya, L., Prikolota, O., Bashkirtcev, O., Andreev, E., Tkachenko, L., Mospan, M., Batushkin, V., Safonova, L., Ogorodnichuk, A., Pustovit, S., Romanov, S., Burlakova, L., Voloshko, Y., Lafarenko, V., Vlasuk, Z., Leshchuk, O., Chushak, S., Koval, V., Stasuk, O., Pogrebna, O., Kornienko, S., Tikhonova, S., Fesenko, T., Kuzmina, T., Ushakov, O., Vechtomova, N., Potapska, L., Illushechkin, I., Kryvenkova, E., Lysunets, O., Tsygankov, O., Bardachenko, L., Voloshyna, L., Ginzburg, V., Franskyavichene, L., Korotich, T., Vyshnevaya, N., Bilous, N., Kulinich, S., Kulik, V., Sadykova, I., Berezhna, T., Molotyagina, S., Pham, M. H., Pham, H. T., Khong, N. H., K. B., Do, T. B., Le, P. A., Do, T. C., Do, Nguyen, N. Q., Q. H., Do, K. C., Vu, Pham, N. H., Pham, T. H. T., M. C., Ta, Phan, D. P., Nguyen, T. T. H., Pham, T. T. N., T. L., To, V. T., Le, Dang, L., Bui, L., Pham, T. T. H., Phan, H. H., Bui, T. T. H., Tuong, T. V. A., Nguyen, T. P., Nguyen, T. H., Nguyen, B. K., D. B., Vu, Pham, N. S., T. Q., Do, Pham, T. S., Dang, V. D., D. T., Le, V. C., Do, Nguyen, T. K. L., Luong, H. D., Luu, T. Q., Pham, N. V., Huynh, T. K., N. T. H., Tu, Ngo, K. A., Nguyen, T. T. C., Ong, T. T. L., Doan, V. B., Kim, T. B., T. N., Vo, Tran, T. T. T., Nguyen, T. A., Tran, V. D., Nguyen, A. K., Tran, A. C., Ngo, M. H., N. H., Vu, I. T., Ly, Tran, N. P. H., Tran, L. U. P., Nguyen, T. N., Tran, T. H., Truong, P. H., Mai, T. L., Hoang, V. S., Bui, C. M. A., Dang, V. P., Truong, Q. B., M. P., Vo, Nguyen, V. T., Chau, N. H., T. T. H., Ta, Dinh, H. N., Tran, H., Nguyen, H. K. N., Chung, A., Chung, E., Martina-Hooi, B., Angela, R., Ramoutar, P., Fillet, R., Tilluckdharry, R., Dookie, T., Foster, E., Hart, C., Omardeen, F., Ramphall, S., Lalla, C., Cheng, J., Elliott, V., Falconer, H., Hurlock-Clarke, L., Ishmael, R., Lalljie, G., Lee, K., Liqui-Lung, A., Massay, R., Mohammed, H., Brown, C., Daniel, R., Didier, M., Salas, Z., CHU Trousseau [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), University of Glasgow, Maria Cecilia Hospital [Cotignola], Royal Brompton Hospital, Montreal Heart Institute Coordinating Centre (MHICC), Université de Montréal (UdeM), Medical University of Silesia (SUM), Université Paris Diderot - Paris 7 (UPD7), Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Dorogoichenko, Aleksandra, Laucevičius, Aleksandras, Jurgaitienė, Rūta, Šlapikas, Rimvydas, Barauskienė, Gražina, Jankauskienė, Edita, Revienė, Sigita, Vaišvila, Tautvydas, Zaronskienė, Danutė, Šlapikienė, Ona Birutė, Kupstytė, Nora, Rinkūnienė, Egidija, Steponėnienė, Rima Vitalija, Kojelienė, Jūratė, Badarienė, Jolita, Dženkevičiūtė, Vilma, Sadauskienė, Eglė, Butkuvienė, Irena, Stankevičius, R., Paliulionienė, R., Snikytė, R., Mažutavičius, R., and CLARIFY Investigators
- Subjects
Male ,Genetics and Molecular Biology (all) ,Heart disease ,medicine.medical_treatment ,atrial fibrillation ,coronary ,anticoagulants ,patients ,atrial flutter ,lcsh:Medicine ,Coronary Artery Disease ,Practice Patterns ,030204 cardiovascular system & hematology ,Chest pain ,Biochemistry ,[SHS]Humanities and Social Sciences ,Cohort Studies ,Coronary artery disease ,Angina ,0302 clinical medicine ,Aged ,Anticoagulants ,Atrial Fibrillation ,Drug Therapy, Combination ,Female ,Guideline Adherence ,Humans ,Outpatients ,Platelet Aggregation Inhibitors ,Practice Patterns, Physicians' ,Registries ,Practice Patterns, Physicians'/statistics & numerical data ,030212 general & internal medicine ,Myocardial infarction ,lcsh:Science ,Stroke ,Anticoagulants/administration & dosage ,Multidisciplinary ,Medicine (all) ,Atrial fibrillation ,Guideline Adherence/statistics & numerical data ,3. Good health ,Combination ,Cardiology ,[SHS] Humanities and Social Sciences ,medicine.symptom ,Research Article ,medicine.medical_specialty ,Coronary Artery Disease/drug therapy ,Agricultural and Biological Sciences (all) ,Biochemistry, Genetics and Molecular Biology (all) ,NO ,03 medical and health sciences ,Drug Therapy ,Internal medicine ,medicine ,Platelet Aggregation Inhibitors/administration & dosage ,Physicians' ,Atrial Fibrillation/drug therapy ,business.industry ,lcsh:R ,Percutaneous coronary intervention ,Outpatients/statistics & numerical data ,medicine.disease ,lcsh:Q ,Human medicine ,business - Abstract
BACKGROUND: Few data are available regarding the use of antithrombotic strategies in coronary artery disease patients with atrial fibrillation (AF) in everyday practice. We sought to describe the prevalence of AF and its antithrombotic management in a contemporary population of patients with stable coronary artery disease.METHODS AND FINDINGS: CLARIFY is an international, prospective, longitudinal registry of outpatients with stable coronary artery disease, defined as prior (≥12 months) myocardial infarction, revascularization procedure, coronary stenosis >50%, or chest pain associated with evidence of myocardial ischemia. Overall, 33,428 patients were screened, of whom 32,954 had data available for analysis at baseline; of these 2,229 (6.7%) had a history of AF. Median (interquartile range) CHA2DS2-VASc score was 4 (3, 5). Oral anticoagulation alone was used in 25.7%, antiplatelet therapy alone in 52.8% (single 41.8%, dual 11.0%), and both in 21.5%. OAC use was independently associated with permanent AF (pCONCLUSIONS: In this contemporary cohort of patients with stable coronary artery disease and AF, most of whom are theoretical candidates for anticoagulation, oral anticoagulants were used in only 47.2%. Half of the patients received antiplatelet therapy alone and one-fifth received both antiplatelets and oral anticoagulants. Efforts are needed to improve adherence to guidelines in these patients.TRIAL REGISTRATION: ISRCTN registry of clinical trials: ISRCTN43070564.
- Published
- 2015
27. Mesenchymal Stem Cells Derived from Human Bone Marrow and Adipose Tissue Maintain Their Immunosuppressive Properties After Chondrogenic Differentiation: Role of HLA-G
- Author
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Du, Wen-Jing, primary, Reppel, Loic, additional, Leger, Léonore, additional, Schenowitz, Chantal, additional, Huselstein, Celine, additional, Bensoussan, Danièle, additional, Carosella, Edgardo D., additional, Han, Zhong-Chao, additional, and Rouas-Freiss, Nathalie, additional
- Published
- 2016
- Full Text
- View/download PDF
28. Evidence of indirect allorecognition of HLA /non-HLA antigens expressed by bronchial epithelial cells from lung transplant recipients
- Author
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Bunel, Vincent, primary, Letuve, Severine, additional, Pretolani, Marina, additional, Schenowitz, Chantal, additional, Carosella, Edgardo, additional, Rouass-Freiss, Nathalie, additional, and Brugiere, Olivier, additional
- Published
- 2016
- Full Text
- View/download PDF
29. Habitat and taxon as driving forces of carbohydrate catabolism in marine heterotrophic bacteria: example of the model algae-associated bacterium Zobellia galactanivorans DsijT.
- Author
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Barbeyron, Tristan, Thomas, François, Barbe, Valérie, Teeling, Hanno, Schenowitz, Chantal, Dossat, Carole, Goesmann, Alexander, Leblanc, Catherine, Oliver Glöckner, Frank, Czjzek, Mirjam, Amann, Rudolf, and Michel, Gurvan
- Subjects
CARBOHYDRATE metabolism ,HETEROTROPHIC bacteria ,HABITATS ,MARINE bacteria ,BIOCONVERSION ,STATISTICAL correlation - Abstract
The marine flavobacterium Zobellia galactanivorans Dsij
T was isolated from a red alga and by now constitutes a model for studying algal polysaccharide bioconversions. We present an in-depth analysis of its complete genome and link it to physiological traits. Z. galactanivorans exhibited the highest gene numbers for glycoside hydrolases, polysaccharide lyases and carbohydrate esterases and the second highest sulfatase gene number in a comparison to 125 other marine heterotrophic bacteria (MHB) genomes. Its genome contains 50 polysaccharide utilization loci, 22 of which contain sulfatase genes. Catabolic profiling confirmed a pronounced capacity for using algal polysaccharides and degradation of most polysaccharides could be linked to dedicated genes. Physiological and biochemical tests revealed that Z. galactanivorans stores and recycles glycogen, despite loss of several classic glycogen-related genes. Similar gene losses were observed in most Flavobacteriia, suggesting presence of an atypical glycogen metabolism in this class. Z. galactanivorans features numerous adaptive traits for algae-associated life, such as consumption of seaweed exudates, iodine metabolism and methylotrophy, indicating that this bacterium is well equipped to form profitable, stable interactions with macroalgae. Finally, using statistical and clustering analyses of the MHB genomes we show that their carbohydrate catabolism correlates with both taxonomy and habitat. [ABSTRACT FROM AUTHOR]- Published
- 2016
- Full Text
- View/download PDF
30. Human Keratinocytes Inhibit CD4 + T-Cell Proliferation through TGFB1 Secretion and Surface Expression of HLA-G1 and PD-L1 Immune Checkpoints.
- Author
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Mestrallet, Guillaume, Auvré, Frédéric, Schenowitz, Chantal, Carosella, Edgardo D., LeMaoult, Joel, Martin, Michèle T., Rouas-Freiss, Nathalie, and Fortunel, Nicolas O.
- Subjects
IMMUNE checkpoint proteins ,PROGRAMMED death-ligand 1 ,KERATINOCYTES ,SECRETION ,PROTEIN expression ,KERATINOCYTE differentiation ,T cells - Abstract
Human skin protects the body against infection and injury. This protection involves immune and epithelial cells, but their interactions remain largely unknown. Here, we show that cultured epidermal keratinocytes inhibit allogenic CD4
+ T-cell proliferation under both normal and inflammatory conditions. Inhibition occurs through the secretion of soluble factors, including TGFB1 and the cell-surface expression of HLA-G1 and PD-L1 immune checkpoints. For the first time, we here describe the expression of the HLA-G1 protein in healthy human skin and its role in keratinocyte-driven tissue immunomodulation. The overexpression of HLA-G1 with an inducible vector increased the immunosuppressive properties of keratinocytes, opening up perspectives for their use in allogeneic settings for cell therapy. [ABSTRACT FROM AUTHOR]- Published
- 2021
- Full Text
- View/download PDF
31. Habitat and taxon as driving forces of carbohydrate catabolism in marine heterotrophic bacteria: example of the model algae-associated bacterium Zobellia galactanivorans DsijT.
- Author
-
Barbeyron, Tristan, Thomas, François, Barbe, Valérie, Teeling, Hanno, Schenowitz, Chantal, Dossat, Carole, Goesmann, Alexander, Leblanc, Catherine, Oliver Glöckner, Frank, Czjzek, Mirjam, Amann, Rudolf, and Michel, Gurvan
- Subjects
- *
CARBOHYDRATE metabolism , *HETEROTROPHIC bacteria , *HABITATS , *MARINE bacteria , *BIOCONVERSION , *STATISTICAL correlation - Abstract
The marine flavobacterium Zobellia galactanivorans DsijT was isolated from a red alga and by now constitutes a model for studying algal polysaccharide bioconversions. We present an in-depth analysis of its complete genome and link it to physiological traits. Z. galactanivorans exhibited the highest gene numbers for glycoside hydrolases, polysaccharide lyases and carbohydrate esterases and the second highest sulfatase gene number in a comparison to 125 other marine heterotrophic bacteria (MHB) genomes. Its genome contains 50 polysaccharide utilization loci, 22 of which contain sulfatase genes. Catabolic profiling confirmed a pronounced capacity for using algal polysaccharides and degradation of most polysaccharides could be linked to dedicated genes. Physiological and biochemical tests revealed that Z. galactanivorans stores and recycles glycogen, despite loss of several classic glycogen-related genes. Similar gene losses were observed in most Flavobacteriia, suggesting presence of an atypical glycogen metabolism in this class. Z. galactanivorans features numerous adaptive traits for algae-associated life, such as consumption of seaweed exudates, iodine metabolism and methylotrophy, indicating that this bacterium is well equipped to form profitable, stable interactions with macroalgae. Finally, using statistical and clustering analyses of the MHB genomes we show that their carbohydrate catabolism correlates with both taxonomy and habitat. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
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