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Your search keyword '"Schaapherder, Alexander F. M."' showing total 13 results
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13 results on '"Schaapherder, Alexander F. M."'

1. Effective and safe implementation of robot‐assisted donor nephrectomy by experienced laparoscopic surgeons.

Author

van de Geijn, Emma F., Janki, Shiromani, de Vries, Dorottya K., Nijboer, Willemijn N., Alwayn, Ian P. J., Nieuwenhuizen, Jeroen, Baranski, Andrzej G., Schaapherder, Alexander F. M., de Vries, Aiko P. J., Huurman, Volkert A. L., and Lam, Hwai‐Ding

Abstract

Background: In June 2021, the first robot‐assisted donor nephrectomy (RADN) was performed at the Leiden University Medical Center (LUMC), the Netherlands. The goal of this study was to investigate whether this procedure has been implemented safely and efficiently. Methods: RADN was retrospectively compared to laparoscopic donor nephrectomy (LDN) performed during the same time period (June 2021 until November 2022). Patients were assigned to RADN depending on the availability of the da Vinci robot and surgical team. The studied endpoints were postoperative complications, operative time, estimated blood loss, warm ischemic time (WIT), and postoperative pain experience. For analysis, the Student's t‐test and Chi‐squared test were used for, respectively, continuous and categorical data. Results: Forty RADN were compared to 63 LDN. Total insufflation time was significantly longer in RADN compared to LDN (188 min (169–214) versus 172 min (144–194); p = 0.02). Additionally, WIT was also found to be significantly higher in the robot‐assisted group (04:54 min vs. 04:07 min; p < 0.01). No statistical differences were found in postoperative outcomes (eGFR of the recipient at 3‐month follow‐up, RADN 54.08 mL/min ±18.79 vs. LDN 56.41 mL/min ±16.82; p = 0.52), pain experience, and complication rate. Conclusion: RADN was safely and efficiently implemented at the LUMC. It's results were not inferior to laparoscopic donor nephrectomy. Operative time and warm ischemic times were longer in RADN. This may relate to a learning curve effect. No clinically relevant effect on postoperative outcomes was observed. [ABSTRACT FROM AUTHOR]

Published
2024
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2. A nationwide assessment of hepatocellular adenoma resection:Indications and pathological discordance

Author

Haring, Martijn P D, Elfrink, Arthur K E, Oudmaijer, Christiaan A J, Andel, Paul C M, Furumaya, Alicia, de Jong, Nenke, Willems, Colin J J M, Huits, Thijs, Sijmons, Julie M L, Belt, Eric J T, Bosscha, Koop, Consten, Esther C J, Coolsen, Mariëlle M E, van Duijvendijk, Peter, Erdmann, Joris I, Gobardhan, Paul, de Haas, Robbert J, van Heek, Tjarda, Lam, Hwai-Ding, Leclercq, Wouter K G, Liem, Mike S L, Marsman, Hendrik A, Patijn, Gijs A, Terkivatan, Türkan, Zonderhuis, Babs M, Molenaar, Izaak Quintus, Te Riele, Wouter W, Hagendoorn, Jeroen, Schaapherder, Alexander F M, IJzermans, Jan N M, Buis, Carlijn I, Klaase, Joost M, de Jong, Koert P, de Meijer, Vincent E, Haring, Martijn P D, Elfrink, Arthur K E, Oudmaijer, Christiaan A J, Andel, Paul C M, Furumaya, Alicia, de Jong, Nenke, Willems, Colin J J M, Huits, Thijs, Sijmons, Julie M L, Belt, Eric J T, Bosscha, Koop, Consten, Esther C J, Coolsen, Mariëlle M E, van Duijvendijk, Peter, Erdmann, Joris I, Gobardhan, Paul, de Haas, Robbert J, van Heek, Tjarda, Lam, Hwai-Ding, Leclercq, Wouter K G, Liem, Mike S L, Marsman, Hendrik A, Patijn, Gijs A, Terkivatan, Türkan, Zonderhuis, Babs M, Molenaar, Izaak Quintus, Te Riele, Wouter W, Hagendoorn, Jeroen, Schaapherder, Alexander F M, IJzermans, Jan N M, Buis, Carlijn I, Klaase, Joost M, de Jong, Koert P, and de Meijer, Vincent E

Abstract

Hepatocellular adenomas (HCAs) are benign liver tumors associated with bleeding or malignant transformation. Data on the indication for surgery are scarce. We analyzed indications and outcome of patients operated for HCAs < 50 mm compared to HCAs ≥ 50 mm. Changes in final postoperative diagnosis were assessed. We performed a retrospective study that included patients who underwent resection for (suspected) HCAs in the Netherlands from 2014 to 2019. Indication for resection was analyzed and stratified for small (<50 mm) and large (≥50 mm) tumors. Logistic regression analysis was performed on factors influencing change in tumor diagnosis. Out of 222 patients who underwent surgery, 44 (20%) patients had a tumor <50 mm. Median age was 46 (interquartile range [IQR], 33-56) years in patients with small tumors and 37 (IQR, 31-46) years in patients with large tumors (p = 0.016). Patients with small tumors were more frequently men (21% vs. 5%, p = 0.002). Main indications for resection in patients with small tumors were suspicion of (pre)malignancy (55%), (previous) bleeding (14%), and male sex (11%). Patients with large tumors received operations because of tumor size >50 mm (52%), suspicion of (pre)malignancy (28%), and (previous) bleeding (5.1%). No difference was observed in HCA-subtype distribution between small and large tumors. Ninety-six (43%) patients had a postoperative change in diagnosis. Independent risk factors for change in diagnosis were tumor size <50 mm (adjusted odds ratio [aOR], 3.4; p < 0.01), male sex (aOR, 3.7; p = 0.03), and lack of hepatobiliary contrast-enhanced magnetic resonance imaging (CE-MRI) (aOR, 1.8; p = 0.04). Resection for small (suspected) HCAs was mainly indicated by suspicion of (pre)malignancy, whereas for large (suspected) HCAs, tumor size was the most prevalent indication. Male sex, tumor size <50 mm, and lack of hepatobiliary CE-MRI were independent risk factors for postoperative change in tumor diagnosis.

Published
2023

3. The Non-Muscle-Splitting Mini-Incision Donor Nephrectomy Remains a Feasible Technique in the Laparoscopic Era of Living Kidney Donation

Author

Habets, Lex J. M., primary, Baranski, Andrzej G., additional, Ramdhani, Khalil, additional, van der Helm, Danny, additional, Haasnoot, Ada, additional, de Vries, Aiko P. J., additional, van der Bogt, Koen E. A., additional, Braat, Andries E., additional, Dubbeld, Jeroen, additional, Lam, Hwai-Ding, additional, Nieuwenhuizen, Jeroen, additional, Nijboer, Willemijn N., additional, de Vries, Dorottya. K., additional, Alwayn, Ian P. J., additional, Schaapherder, Alexander F. M., additional, and Huurman, Volkert A. L., additional

Published
2022
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4. The Non-Muscle-Splitting Mini-Incision Donor Nephrectomy Remains a Feasible Technique in the Laparoscopic Era of Living Kidney Donation.

Author

Habets, Lex J. M., Baranski, Andrzej G., Ramdhani, Khalil, van der Helm, Danny, Haasnoot, Ada, de Vries, Aiko P. J., van der Bogt, Koen E. A., Braat, Andries E., Dubbeld, Jeroen, Lam, Hwai-Ding, Nieuwenhuizen, Jeroen, Nijboer, Willemijn N., de Vries, Dorottya. K., Alwayn, Ian P. J., Schaapherder, Alexander F. M., and Huurman, Volkert A. L.

Subjects
ISCHEMIA, PERIOPERATIVE care, SKELETAL muscle, NEPHRECTOMY, KIDNEYS, MULTIVARIATE analysis, RETROSPECTIVE studies, GRAFT survival, FISHER exact test, REGRESSION analysis, T-test (Statistics), LAPAROSCOPY, CHI-squared test, DATA analysis software, ORGAN donors, ORGAN donation, LONGITUDINAL method
Abstract

Laparoscopic donor nephrectomy (LDN) is the current gold standard in kidney donation. Mini-incision open donor nephrectomy (MINI) techniques have been used extensively but have become less popular. The aim of the present study was to compare the results and safety of a non-muscle-splitting MINI technique with the current gold standard of LDN. A single center retrospective cohort study of all living donor nephrectomies between 2011 and 2019 was used for the study. The primary outcome of this study was short term (<30 days) with Clavien–Dindo grade complications. Secondary outcomes included multivariable regression analysis of perioperative data. No differences in complication rates were observed between MINI and LDN and also after correction for known confounders. As expected, the operative time and first warm ischemia were significantly shorter in the MINI group and less blood loss was observed in the LDN group. Complications and conversion rate (LDN to open) among the LDN patients were in line with recent published meta-analyses. This study confirms the perioperative safety of living kidney donation in modern practice. Complication rates of both MINI and LDN procedures are limited and not different between procedures. In specific circumstances, the MINI procedure can still be considered a safe and feasible alternative for living kidney donation. [ABSTRACT FROM AUTHOR]

Published
2023
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6. Improving outcomes for donation after circulatory death kidney transplantation: Science of the times

Author

MS Nefrologie, Circulatory Health, de Kok, Michèle J C, Schaapherder, Alexander F M, Alwayn, Ian P J, Bemelman, Frederike J, van de Wetering, Jacqueline, van Zuilen, Arjan D, Christiaans, Maarten H L, Baas, Marije C, Nurmohamed, Azam S, Berger, Stefan P, Bastiaannet, Esther, Ploeg, Rutger J, de Vries, Aiko P J, Lindeman, Jan H N, MS Nefrologie, Circulatory Health, de Kok, Michèle J C, Schaapherder, Alexander F M, Alwayn, Ian P J, Bemelman, Frederike J, van de Wetering, Jacqueline, van Zuilen, Arjan D, Christiaans, Maarten H L, Baas, Marije C, Nurmohamed, Azam S, Berger, Stefan P, Bastiaannet, Esther, Ploeg, Rutger J, de Vries, Aiko P J, and Lindeman, Jan H N

Published
2020

7. Improving outcomes for donation after circulatory death kidney transplantation: Science of the times

Author

de Kok, Michèle J. C., primary, Schaapherder, Alexander F. M., additional, Alwayn, Ian P. J., additional, Bemelman, Frederike J., additional, van de Wetering, Jacqueline, additional, van Zuilen, Arjan D., additional, Christiaans, Maarten H. L., additional, Baas, Marije C., additional, Nurmohamed, Azam S., additional, Berger, Stefan P., additional, Bastiaannet, Esther, additional, Ploeg, Rutger J., additional, de Vries, Aiko P. J., additional, and Lindeman, Jan H. N., additional

Published
2020
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8. Preclinical models versus clinical renal ischemia reperfusion injury: A systematic review based on metabolic signatures

Author

Lerink, Lente J. S., Kok, Michèle J. C., Mulvey, John F., Le Dévédec, Sylvia E., Markovski, Alexander A., Wüst, Rob C. I., Alwayn, Ian P. J., Ploeg, Rutger J., Schaapherder, Alexander F. M., Bakker, Jaap A., and Lindeman, Jan H. N.

Abstract

Despite decennia of research and numerous successful interventions in the preclinical setting, renal ischemia reperfusion (IR) injury remains a major problem in clinical practice, pointing toward a translational gap. Recently, two clinical studies on renal IR injury (manifested either as acute kidney injury or as delayed graft function) identified metabolic derailment as a key driver of renal IR injury. It was reasoned that these unambiguous metabolic findings enable direct alignment of clinical with preclinical data, thereby providing the opportunity to elaborate potential translational hurdles between preclinical research and the clinical context. A systematic review of studies that reported metabolic data in the context of renal IR was performed according to the PRISMA guidelines. The search (December 2020) identified 35 heterogeneous preclinical studies. The applied methodologies were compared, and metabolic outcomes were semi‐quantified and aligned with the clinical data. This review identifies profound methodological challenges, such as the definition of IR injury, the follow‐up time, and sampling techniques, as well as shortcomings in the reported metabolic information. In light of these findings, recommendations are provided in order to improve the translatability of preclinical models of renal IR injury. A comparison of metabolic responses in clinical and experimental renal ischemia reperfusion identifies multiple translational gaps.

Published
2022
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9. Pancreas transplantation with grafts from donors deceased after circulatory death (DCD): 5 years single center experience

Author

Kopp, Wouter H, Lam, Hwai-Ding, Schaapherder, Alexander F M, Huurman, Volkert A L, van der Boog, Paul, de Koning, Eelco, de Fijter, Johan W, Baranski, Andrzej, Braat, Andries E, Kopp, Wouter H, Lam, Hwai-Ding, Schaapherder, Alexander F M, Huurman, Volkert A L, van der Boog, Paul, de Koning, Eelco, de Fijter, Johan W, Baranski, Andrzej, and Braat, Andries E

Abstract

INTRODUCTION: Donation after circulatory death (DCD) pancreas transplantation has been shown to be an additional way to deal with donor organ shortages. The results of 5-year DCD pancreas transplantation are presented.METHODS: A retrospective, single center analysis (2011 - 2015) was performed to compare the results of donation after brain death (DBD) to DCD pancreas transplantation.RESULTS: During the study period, 104 pancreas transplantations (83 from DBD and 21 from DCD) were performed. Median pancreas donor risk index (PDRI) was 1.47, (DBD 1.61 vs. DCD 1.35 (p=0.144)). Without the factor DCD, PDRI from DCD donors was significantly lower (DBD 1.61 vs DCD 0.97 (p<0.001). Donor age was the only donor related risk factor associated with pancreas graft survival (HR 1.06, p=0.037). Postoperative bleeding and kidney DGF occurred more frequently in recipients from DCD (p=0.006). However, DCD pancreata had a lower incidence of thrombosis. Kidney and pancreas graft survival were equally good in both groups.CONCLUSIONS: Pancreas transplantation from DCD donors yields comparable results to DBD donors when PDRI of DCD are relatively low. Most DCD donors are younger donors with trauma as cause of death. These DCD pancreas grafts may be a better option to cope with increasing organ shortages than exploring the limits with older (and higher PDRI) DBD donors.

Published
2017

10. Thirty Years of Pancreas Transplantation at Leiden University Medical Center: Long-Term Follow-Up in a Large Eurotransplant Center

Author

Kopp, Wouter H, Verhagen, Merel J J, Blok, Joris J, Huurman, Volkert A L, de Fijter, Johan W, de Koning, Eelco J, Putter, Hein, Baranski, Andzrej G, Schaapherder, Alexander F M, Braat, Andries E, Ringers, Jan, Kopp, Wouter H, Verhagen, Merel J J, Blok, Joris J, Huurman, Volkert A L, de Fijter, Johan W, de Koning, Eelco J, Putter, Hein, Baranski, Andzrej G, Schaapherder, Alexander F M, Braat, Andries E, and Ringers, Jan

Abstract

BACKGROUND: An overview of 30 years of pancreas transplantation at a high volume center. Analysis of patient survival- and graft survival-associated risk factors.METHODS: All pancreas transplantations performed in our center from January 1, 1984, till December 31, 2012, were evaluated. Covariates influencing pancreas graft survival were analyzed using both univariate and multivariate analysis and Kaplan-Meier analysis.RESULTS: In the study period, 349 pancreas transplantations were performed. With the introduction of modern induction therapy in 1999, 5-year patient survival improved to 92.0% (P = 0.003). Five-year pancreas graft survival improved to 80.3% (P = 0.026). Pancreas graft survival was influenced by left or right donor kidney, transplant type, local origin of procurement team, pancreas cold ischemia time, recipient cerebrovascular disease. Pancreas donor risk index increased to 1.39 over the years and pancreas donor risk index 1.24 or higher is a risk factor for graft survival (P = 0.007).CONCLUSIONS: This study has shown excellent results in patient and pancreas graft survivals after 30 years of pancreas transplantation in a high volume center. Different donor, transplant, and recipient related risk factors influence pancreas graft survival. Even with higher risk pancreas donors, good results can be achieved.

Published
2015

11. Thirty Years of Pancreas Transplantation at Leiden University Medical Center

Author

Kopp, Wouter H., primary, Verhagen, Merel J. J., additional, Blok, Joris J., additional, Huurman, Volkert A. L., additional, de Fijter, Johan W., additional, de Koning, Eelco J., additional, Putter, Hein, additional, Baranski, Andzrej G., additional, Schaapherder, Alexander F. M., additional, Braat, Andries E., additional, and Ringers, Jan, additional

Published
2015
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12. Pathophysiological concepts of ischemia-reperfusion injury and normothermic, ex vivo kidney perfusion.

Author

Lindeman JHN and Schaapherder AFM

Subjects
Humans, Organ Preservation methods, Animals, Reperfusion Injury etiology, Perfusion, Kidney blood supply, Kidney physiopathology, Kidney Transplantation
Abstract

Competing Interests: Declaration of competing interest The authors of this manuscript have no conflicts of interest to disclose as described by the American Journal of Transplantation.

Published
2024
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13. A nationwide assessment of hepatocellular adenoma resection: Indications and pathological discordance.

Author

Haring MPD, Elfrink AKE, Oudmaijer CAJ, Andel PCM, Furumaya A, de Jong N, Willems CJJM, Huits T, Sijmons JML, Belt EJT, Bosscha K, Consten ECJ, Coolsen MME, van Duijvendijk P, Erdmann JI, Gobardhan P, de Haas RJ, van Heek T, Lam HD, Leclercq WKG, Liem MSL, Marsman HA, Patijn GA, Terkivatan T, Zonderhuis BM, Molenaar IQ, Te Riele WW, Hagendoorn J, Schaapherder AFM, IJzermans JNM, Buis CI, Klaase JM, de Jong KP, and de Meijer VE

Subjects
Humans, Male, Adult, Middle Aged, Retrospective Studies, Magnetic Resonance Imaging methods, Adenoma, Liver Cell diagnostic imaging, Adenoma, Liver Cell surgery, Liver Neoplasms diagnostic imaging, Liver Neoplasms surgery, Carcinoma, Hepatocellular pathology
Abstract

Hepatocellular adenomas (HCAs) are benign liver tumors associated with bleeding or malignant transformation. Data on the indication for surgery are scarce. We analyzed indications and outcome of patients operated for HCAs < 50 mm compared to HCAs ≥ 50 mm. Changes in final postoperative diagnosis were assessed. We performed a retrospective study that included patients who underwent resection for (suspected) HCAs in the Netherlands from 2014 to 2019. Indication for resection was analyzed and stratified for small (<50 mm) and large (≥50 mm) tumors. Logistic regression analysis was performed on factors influencing change in tumor diagnosis. Out of 222 patients who underwent surgery, 44 (20%) patients had a tumor <50 mm. Median age was 46 (interquartile range [IQR], 33-56) years in patients with small tumors and 37 (IQR, 31-46) years in patients with large tumors ( p  = 0.016). Patients with small tumors were more frequently men (21% vs. 5%, p  = 0.002). Main indications for resection in patients with small tumors were suspicion of (pre)malignancy (55%), (previous) bleeding (14%), and male sex (11%). Patients with large tumors received operations because of tumor size >50 mm (52%), suspicion of (pre)malignancy (28%), and (previous) bleeding (5.1%). No difference was observed in HCA-subtype distribution between small and large tumors. Ninety-six (43%) patients had a postoperative change in diagnosis. Independent risk factors for change in diagnosis were tumor size <50 mm (adjusted odds ratio [aOR], 3.4; p  < 0.01), male sex (aOR, 3.7; p  = 0.03), and lack of hepatobiliary contrast-enhanced magnetic resonance imaging (CE-MRI) (aOR, 1.8; p  = 0.04). Resection for small (suspected) HCAs was mainly indicated by suspicion of (pre)malignancy, whereas for large (suspected) HCAs, tumor size was the most prevalent indication. Male sex, tumor size <50 mm, and lack of hepatobiliary CE-MRI were independent risk factors for postoperative change in tumor diagnosis., (Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc on behalf of the American Association for the Study of Liver Diseases.)

Published
2022
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