141 results on '"Sarubbi, B"'
Search Results
2. Right atrial performance of adult patients with repaired tetralogy of fallot
- Author
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Borrelli, N, primary, La Rocca, F, additional, Sorice, D, additional, Ciriello, G D, additional, Barracano, R, additional, Grimaldi, N, additional, Fusco, F, additional, Merola, A, additional, Correra, A, additional, Palma, M, additional, Scognamiglio, G, additional, and Sarubbi, B, additional
- Published
- 2023
- Full Text
- View/download PDF
3. Dapaglifozin in adults with a systemic right ventricle:initial results from the DAPA-SERVE trial
- Author
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Abbate, M, primary, Fusco, F, additional, Scognamiglio, G, additional, Merola, A, additional, Palma, M, additional, Grimaldi, N, additional, Barracano, R, additional, Borrelli, N, additional, Ppaccioli, G, additional, Sorice, D, additional, Roma, A S, additional, Colonna, D, additional, Correra, A, additional, Romeo, E, additional, and Sarubbi, B, additional
- Published
- 2023
- Full Text
- View/download PDF
4. C48 TEN–YEARS, SINGLE–CENTER EXPERIENCE WITH MELODY TPV IMPLANTATION: EARLY OUTCOMES AND MID–TERM FOLLOW–UP
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Giordano, M, primary, Marzullo, R, additional, Gaio, G, additional, Cappelli Bigazzi, M, additional, Fabiani, D, additional, Palladino, M, additional, Della Cioppa, N, additional, Sarubbi, B, additional, and Russo, M, additional
- Published
- 2023
- Full Text
- View/download PDF
5. End-stage heart failure in congenitally corrected transposition of the great arteries:a multicentre study
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van Dissel, AC, Opotowsky, AR, Burchill, LJ, Aboulhosn, J, Grewal, J, Lubert, AM, Antonova, P, Shah, S, Cotts, T, John, AS, Kay, WA, DeZorzi, C, Magalski, A, Han, F, Baker, D, Kay, J, Yeung, ELZB, Vonder Muhll, I, Pylypchuk, S, Kuo, MC, Nicolarsen, J, Sarubbi, B, Fusco, F, Jameson, SM, Cramer, J, Gupta, T, Gallego, P, O'Donnell, C, Hannah, J, Dellborg, M, Kauling, RM, Ginde, S, Krieger, EV, Rodriguez, F, Dehghani, P, Kutty, S, Wong, JS, Wilson, WM, Rodriguez-Monserrate, CP, Roos-Hesselink, J, Celermajer, DS, Khairy, P, Broberg, CS, van Dissel, AC, Opotowsky, AR, Burchill, LJ, Aboulhosn, J, Grewal, J, Lubert, AM, Antonova, P, Shah, S, Cotts, T, John, AS, Kay, WA, DeZorzi, C, Magalski, A, Han, F, Baker, D, Kay, J, Yeung, ELZB, Vonder Muhll, I, Pylypchuk, S, Kuo, MC, Nicolarsen, J, Sarubbi, B, Fusco, F, Jameson, SM, Cramer, J, Gupta, T, Gallego, P, O'Donnell, C, Hannah, J, Dellborg, M, Kauling, RM, Ginde, S, Krieger, EV, Rodriguez, F, Dehghani, P, Kutty, S, Wong, JS, Wilson, WM, Rodriguez-Monserrate, CP, Roos-Hesselink, J, Celermajer, DS, Khairy, P, and Broberg, CS
- Abstract
BACKGROUND AND AIMS: For patients with congenitally corrected transposition of the great arteries (ccTGA), factors associated with progression to end-stage congestive heart failure (CHF) remain largely unclear. METHODS: This multicentre, retrospective cohort study included adults with ccTGA seen at a congenital heart disease centre. Clinical data from initial and most recent visits were obtained. The composite primary outcome was mechanical circulatory support, heart transplantation, or death. RESULTS: From 558 patients (48% female, age at first visit 36 ± 14.2 years, median follow-up 8.7 years), the event rate of the primary outcome was 15.4 per 1000 person-years (11 mechanical circulatory support implantations, 12 transplantations, and 52 deaths). Patients experiencing the primary outcome were older and more likely to have a history of atrial arrhythmia. The primary outcome was highest in those with both moderate/severe right ventricular (RV) dysfunction and tricuspid regurgitation (n = 110, 31 events) and uncommon in those with mild/less RV dysfunction and tricuspid regurgitation (n = 181, 13 events, P < .001). Outcomes were not different based on anatomic complexity and history of tricuspid valve surgery or of subpulmonic obstruction. New CHF admission or ventricular arrhythmia was associated with the primary outcome. Individuals who underwent childhood surgery had more adverse outcomes than age- and sex-matched controls. Multivariable Cox regression analysis identified older age, prior CHF admission, and severe RV dysfunction as independent predictors for the primary outcome. CONCLUSIONS: Patients with ccTGA have variable deterioration to end-stage heart failure or death over time, commonly between their fifth and sixth decades. Predictors include arrhythmic and CHF events and severe RV dysfunction but not anatomy or need for tricuspid valve surgery.
- Published
- 2023
6. Gravidanza e cardiopatie: il ruolo del Pregnancy Heart Team
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Parrini, I., Luca, F., Favilli, S., Domenicucci, S., Russo, M.G., Sarubbi, B., Gelsomino, S., Colivicchi, F., Gulizia, M.M., CTC, and RS: Carim - V04 Surgical intervention
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SCIENTIFIC STATEMENT ,VENOUS THROMBOEMBOLISM ,Acquired heart disease ,PERIPARTUM CARDIOMYOPATHY ,HYPERTROPHIC CARDIOMYOPATHY ,HYPERTENSIVE DISORDERS ,CARDIOVASCULAR-DISEASE ,FAILURE ASSOCIATION ,CARDIAC-DISEASE ,Pregnancy Heart Team ,EUROPEAN-SOCIETY ,Congenital heart disease ,TASK-FORCE - Abstract
A significant risk of maternal and fetal morbidity and mortality has been shown to be associated with congenital heart disease or heart disease occurring during pregnancy. Given the increasing number of patients with corrected congenital heart disease who reach fertile age and the more and more common advanced maternal age associated with preexisting or intercurrent comorbidities, a higher incidence of cardiac complications in pregnancy has been reported in the last decades. Improvement in maternal and neonatal outcomes is influenced by a multidisciplinary strategy. The purpose of this review is to assess the role of the Pregnancy Heart Team which should ensure careful pre-pregnancy counseling, pregnancy monitoring, and delivery planning for both congenital heart disease and other cardiac or metabolic disorders.
- Published
- 2022
7. COVID-19 vaccination in adults with congenital heart disease: results of 1-year prospective study
- Author
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Roma, A S, primary, Fusco, F, additional, Papaccioli, G, additional, Abbate, M, additional, Scognamiglio, G, additional, Merola, A, additional, Palma, M, additional, Correra, A, additional, Borrelli, N, additional, Barracano, R, additional, Grimaldi, N, additional, Colonna, D, additional, Romeo, E, additional, and Sarubbi, B, additional
- Published
- 2022
- Full Text
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8. Myocardial work impairment in children with Wolff-Parkinson-White syndrome
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Borrelli, N, primary, Di Salvo, G, additional, Ciriello, G D, additional, Sabatino, J, additional, Grimaldi, N, additional, Barracano, R, additional, Fusco, F, additional, Merola, A, additional, Correra, A, additional, Romeo, E, additional, Colonna, D, additional, Palma, M, additional, Scognamiglio, G, additional, Russo, M G, additional, and Sarubbi, B, additional
- Published
- 2022
- Full Text
- View/download PDF
9. Effects of sacubitril/valsartan in patients with a systemic right ventricle
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Fusco, F, primary, Scognamiglio, G, additional, Merola, A, additional, Iannuzzi, A, additional, Palma, M, additional, Borrelli, N, additional, Barracano, R, additional, Correra, A, additional, Ciriello, G D, additional, Grimaldi, N, additional, Colonna, D, additional, Romeo, E, additional, and Sarubbi, B, additional
- Published
- 2022
- Full Text
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10. External validation of a risk score model for predicting major clinical events in adults after atrial switch
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Albertini, M., primary, Fusco, F., additional, Sarubbi, B., additional, Gallego, P., additional, Rodriguez-Puras, M.J., additional, Prokselj, K., additional, Kauling, M., additional, Roos-Hesselink, J., additional, Labombarda, F., additional, Van De Bruaene, A., additional, Santes, B., additional, Buts, W., additional, Iserin, L., additional, Woudstra, O., additional, Bouma, B., additional, and Ladouceur, M., additional
- Published
- 2022
- Full Text
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11. P156 TRANSCATHETER CLOSURE OF ATRIAL SEPTAL DEFECT IN OVER 60 YEARS OLD PATIENTS
- Author
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Marzullo, R, primary, Gaio, G, additional, Giordano, M, additional, Palladino, M, additional, Ancona, R, additional, Scognamiglio, G, additional, D‘Alto, M, additional, Russo, M, additional, and Sarubbi, B, additional
- Published
- 2022
- Full Text
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12. C84 PERCUTANEOUS TREATMENT OF INTERATRIAL MULTIFENESTRATE ANEURYSM IN PAEDIATRIC POPULATION: INFLUENCE OF THE LAYOUT DURING MID–TERM AND LONG–TERM FOLLOW–UP
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Ancona, R, primary, Gaio, G, additional, Giordano, M, additional, Marzullo, R, additional, Cappelli Bigazzi, M, additional, Palladino, M, additional, Scognamiglio, G, additional, Sarubbi, B, additional, and Russo, M, additional
- Published
- 2022
- Full Text
- View/download PDF
13. Blood flow vortices adapt their behaviour to the presence of kent accessory pathway
- Author
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Borrelli, N, primary, Di Salvo, G, additional, Ciriello, GD, additional, Grimaldi, N, additional, Barracano, R, additional, Fusco, F, additional, Merola, A, additional, Correra, A, additional, Colonna, D, additional, Palma, M, additional, Scognamiglio, G, additional, Russo, MG, additional, and Sarubbi, B, additional
- Published
- 2022
- Full Text
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14. Impaired myocardial work in paediatric patients with wolff-parkinson-white syndrome
- Author
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Borrelli, N, primary, Di Salvo, G, additional, Ciriello, GD, additional, Sabatino, J, additional, Bucciarelli, V, additional, Grimaldi, N, additional, Barracano, R, additional, Fusco, F, additional, Merola, A, additional, Correra, A, additional, Romeo, E, additional, Palma, M, additional, Scognamiglio, G, additional, Russo, MG, additional, and Sarubbi, B, additional
- Published
- 2022
- Full Text
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15. Myocardial work indices and ventricular dyssynchrony in adults with aortic coarctation
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Fusco, F, primary, Scognamiglio, G, additional, Merola, A, additional, Roma, AS, additional, Del Giudice, C, additional, Abbate, M, additional, Palma, M, additional, Correra, A, additional, Borrelli, N, additional, Barracano, R, additional, Grimaldi, N, additional, Colonna, D, additional, Romeo, E, additional, and Sarubbi, B, additional
- Published
- 2022
- Full Text
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16. The management of adult congenital heart disease in the emergency department. The Task Force from the Italian Society of Pediatric Cardiology and Congenital Heart Disease
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Gagliardi M. G., Barracano R., Palmieri R., Chessa M., Ferraris L., Sarubbi B., D'Alto M., Assenza G. E., Donti A., Gagliardi, M. G., Barracano, R., Palmieri, R., Chessa, M., Ferraris, L., Sarubbi, B., D'Alto, M., Assenza, G. E., and Donti, A.
- Subjects
Adult ,Heart Defects, Congenital ,Emergency department ,Cardiology ,Eisenmenger syndrome ,Heart failure ,Arrhythmias, Cardiac ,Arrhythmias ,Italy ,Pregnancy ,Humans ,Adult congenital heart disease ,Infective endocarditis ,Child ,Emergency Service, Hospital - Abstract
Over recent years, thanks to remarkable advances in pediatric cardiology, cardiac surgery and catheter interventions, survival of children with congenital heart disease has significantly increased with the majority of patients surviving into adulthood. Therefore, the prevalence of adult patients with congenital heart disease has dramatically increased, as well as the need for specific and dedicated programs. Acute heart failure, infective endocarditis and arrhythmias represent the most common causes of visit in the emergency department in this population. Our task force aimed at guiding physicians taking care of this peculiar cohort of patients in the emergency department.
- Published
- 2021
17. Prognostic relevance of thyroid disease in adults with congenital heart disease
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Fusco, F, primary, Scognamiglio, G, additional, Guarguagli, S, additional, Merola, A, additional, Palma, M, additional, Borrelli, N, additional, Barracano, R, additional, Grimaldi, N, additional, Correra, A, additional, Piccolo, G, additional, La Rocca, F, additional, Del Giudice, C, additional, Colonna, D, additional, Romeo, E, additional, and Sarubbi, B, additional
- Published
- 2021
- Full Text
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18. The adding value of fluid challenge and balloon occlusion tests in patients with atrial septal defect
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D'Alto, M, primary, Chessa, M, additional, Santoro, G, additional, Giordano, M, additional, Gaio, G, additional, Romeo, E, additional, Argiento, P, additional, Wacker, J, additional, D'Aiello, F, additional, Sarubbi, B, additional, Russo, M G, additional, Golino, P, additional, Costantine, A, additional, Naeije, R, additional, and Dimopoulos, K, additional
- Published
- 2021
- Full Text
- View/download PDF
19. Effects of sacubitril/valsartan in patients with a systemic right ventricle: early evidence of exercise tolerance and systolic function improvement
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Fusco, F, primary, Merola, A, additional, Scognamiglio, G, additional, Palma, M, additional, Correra, A, additional, Barracano, R, additional, Borrelli, N, additional, Grimaldi, N, additional, Spinelli Barrile, C, additional, Puzone, N, additional, Ciriello, G D, additional, Colonna, D, additional, Romeo, E, additional, and Sarubbi, B, additional
- Published
- 2021
- Full Text
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20. Electrophysiological Study Prognostic Value and Long-Term Outcome in Drug-Induced Type 1 Brugada Syndrome: The IBRYD Study
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Russo, V., Pafundi, P. C., Caturano, A., Dendramis, G., Ghidini, A. O., Santobuono, V. E., Sciarra, L., Notarstefano, P., Rucco, M. A., Attena, E., Floris, R., Romeo, E., Sarubbi, B., Nigro, G., D'Onofrio, A., Calo, L., and Nesti, M.
- Subjects
electrophysiological study ,implantable cardioverter-defibrillator ,arrhythmia ,Brugada syndrome ,drug-induced type 1 Brugada syndrome ,sudden cardiac death - Published
- 2021
21. Unexplained sudden cardiac arrest in children: clinical and genetic characteristics of survivors
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Monda, E, Sarubbi, B, Russo, M, Caiazza, M, Mazzaccara, C, Magrelli, J, Rubino, M, Esposito, A, Perna, A, Passariello, A, Bossone, E, Romeo, E, Colonna, D, Esposito, M, D'Argenio, V, Salvatore, F, Pacileo, G, Crotti, L, Frisso, G, Limongelli, G, Russo, MG, Esposito, MV, Limongelli, G., Monda, E, Sarubbi, B, Russo, M, Caiazza, M, Mazzaccara, C, Magrelli, J, Rubino, M, Esposito, A, Perna, A, Passariello, A, Bossone, E, Romeo, E, Colonna, D, Esposito, M, D'Argenio, V, Salvatore, F, Pacileo, G, Crotti, L, Frisso, G, Limongelli, G, Russo, MG, Esposito, MV, and Limongelli, G.
- Published
- 2021
22. Italian Validation of the Healthcare Needs Scale for Youth with Congenital Heart Disease and Its Short-Form Development
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Dellafiore, F, Flocco, Sf, Arrigoni, C, Barello, Serena, Nania, T, Russo, Mg, Sarubbi, B, Magon, A, Pittella, F, Chessa, M, Caruso, R, Barello, S (ORCID:0000-0002-8514-2563), Dellafiore, F, Flocco, Sf, Arrigoni, C, Barello, Serena, Nania, T, Russo, Mg, Sarubbi, B, Magon, A, Pittella, F, Chessa, M, Caruso, R, and Barello, S (ORCID:0000-0002-8514-2563)
- Abstract
Aims: This study aimed at providing an Italian short version of the 'healthcare needs scale for youth with congenital heart disease' (I-HNS-CHD-s), describing its construct validity and reliability. Methods: A multi-method and multi-phase design were adopted. Phase one referred to the cultural-linguistic validation of the original scale into Italian Phase two tasted content and face validity of the Italian-translated scale. Phase three included the psychometric validation process of scale, encompassed two different steps: first cross-sectional data collection (sample A) purposed at determining the psychometric characteristics of the I-HNS-CHD-s, using an exploratory factor analysis (EFA). Then, a second round of cross-sectional data collection (sample B) was performed using the version of I-HNS-CHD-s derived from the previous step, and it purposed at confirming the scale factor structure and at assessing its reliability. Results: IHNS-CHD-s showed evidence of face and content validity, adequate construct and internal consistency and stability. Specifically, I-HNS-CHD-s had 14 items kept by four domains, labelled as follows: Healthcare education, clinical support, emotional support, continuum of care. These domains were predicted by a secondorder factor, which was labelled as Healthcare needs. Overall I-HNS-CHD-s encompassed only the items that showed high performance in the psychometric analysis. Accordingly, I-HNS-CHD-s is a shorter form of the original scale (14 items instead of 25). Conclusions: I-HNS-CHD-s is a psychometrically robust measure of the healthcare and psychosocial needs of Italian adolescents and young adults with congenital heart disease.
- Published
- 2020
23. Response to fluid challenge in patients with atrial septal defect
- Author
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D'Alto, M, primary, Chessa, M, additional, Gaio, G, additional, Santoro, G, additional, Giordano, M, additional, Romeo, E, additional, Argiento, P, additional, Wacker, J, additional, D'Aiello, F, additional, Sarubbi, B, additional, Russo, M.G, additional, Naeije, R, additional, and Golino, P, additional
- Published
- 2020
- Full Text
- View/download PDF
24. P781 Role of serum biomarkers combined with two-dimensional speckle tracking echocardiography for screening of immunotherapy-induced cardiotoxicity
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Fusco, F, primary, Scognamiglio, G, additional, Vitiello, F, additional, Gilli, M, additional, Piantedosi, F, additional, Colonna, D, additional, Palma, M, additional, Granata, G, additional, and Sarubbi, B, additional
- Published
- 2020
- Full Text
- View/download PDF
25. 1107 An unusual vegetation on a prosthetic pulmonary valve
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Fusco, F, primary, Scognamiglio, G, additional, Colonna, D, additional, Palma, M, additional, Granata, G, additional, Russo, M G, additional, and Sarubbi, B, additional
- Published
- 2020
- Full Text
- View/download PDF
26. PREVALENCE OF ELEVATED LOW DENSITY LIPOPROTEIN CHOLESTEROL (LDL–C) LEVELS IN ADULT PATIENTS WITH COMPLEX CONGENITAL HEART DISEASE
- Author
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Liguori, C, Siracusa, A, Orlando, A, Franzese, R, Borrelli, N, Barracano, R, Scognamiglio, G, and Sarubbi, B
- Published
- 2024
- Full Text
- View/download PDF
27. 4972Upfront triple combination therapy with ambrisentan, tadalafil and subcutaneous treprostinil in incident patients with severe pulmonary arterial hypertension
- Author
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D'Alto, M, primary, Romeo, E, additional, Argiento, P, additional, Badagliacca, R, additional, Papa, S, additional, Farro, A, additional, Sarubbi, B, additional, Russo, M G, additional, Vizza, C D, additional, and Golino, P, additional
- Published
- 2019
- Full Text
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28. P4160Safety and efficacy of triple combination therapy with parenteral prostanoids in patients with Eisenmenger physiology
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D'Alto, M, primary, Balint, O H, additional, Giannakoulas, G, additional, Romeo, E, additional, Argiento, P, additional, Farro, A, additional, Russo, M G, additional, Sarubbi, B, additional, Skoro-Sajer, N, additional, Gatzoulis, M A, additional, and Dimopoulos, K, additional
- Published
- 2019
- Full Text
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29. Efficacy and safety of dabigatran in a 'real-life' population at high thromboembolic and hemorrhagic risk: data from MonaldiCare registry
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Russo V, Bianchi V, Cavallaro C, Vecchione F, De Vivo S, Santangelo L, Sarubbi B, paolo calabrò, Nigro G, D'Onofrio A, Russo, V, Bianchi, V, Cavallaro, C, Vecchione, F, De Vivo, S, Santangelo, Lucio, Sarubbi, B, Calabro', Paolo, Nigro, Gerardo, and D'Onofrio, A.
- Subjects
Male ,Hemorrhage ,Middle Aged ,Antithrombins ,Dabigatran ,Cohort Studies ,Stroke ,Treatment Outcome ,Italy ,Risk Factors ,Population Surveillance ,Thromboembolism ,Atrial Fibrillation ,Prevalence ,cardiovascular system ,Humans ,Female ,Prospective Studies ,Registries ,cardiovascular diseases ,Dyspepsia ,Aged ,Follow-Up Studies - Abstract
Dabigatran is a novel target specific oral anticoagulant for stroke prevention in non valvular atrial fibrillation. Little is still known about its real-world effectiveness and safety in the italian population. Aim of our study was to evaluate the efficacy and safety of dabigatran in a large single-center cohort of "real-life" italian population with non-valvular AF and to compare the results with those obtained from the RE-LY trial and the Medicare study.We studied a prospective cohort of 2108 patients (1119 male; mean age 69.4 ± 9.4 years) who started the oral anticoagulant treatment with dabigatran 110 mg twice-daily (DAB 110; N = 1075; 51%) or 150 mg twice-daily (DAB 150; N = 1033; 49%). Follow-up data were obtained trough outpatients visits each 3-6 months for assessing the clinical status, adherence to treatment, occurrence of side effects and major cardiovascular complications.In DAB 150 group the mean age was 64.9 ± 8.8 years, 56.8% of patients was male. CHA2DS2Vasc Score was ≥ 3 in 94.3% and HAS-BLED was ≥ 3 in 59.7%. In DAB 110 group (N = 1075) the mean age was 73.9 ± 7.5 years; 49.5% of patients was male. CHA2DS2Vasc Score was ≥ 3 in 73.4% and HAS-BLED was ≥ 3 in 87.4% of DAB 110 patients. One patient taking Dabigatran 110 mg bid had ischemic stroke without significantly neurological sequelae. In both groups, no patient experienced hemorrhagic stroke during the follow-up period. 147 patients (6.9%) of MonaldiCare population reported adverse effects from treatment with dabigatran, of whom 121 patients (5.7%) discontinued therapy. We reported one case of subarachnoid hemorrhage (0.05%) in a patient with high thrombo-embolic and high hemorrhagic risk score who was taking dabigatran 150 mg bid and one case (0.05%) of bladder bleeding in a patient who was taking dabigatran 110 mg bid. No major gastrointestinal bleeding was observed in the MonaldiCare population.MonaldiCare registry showed a safety profile of both dosages of dabigatran regarding major of fatal bleeding in a "real life" single center italian population at high thromboembolic and hemorrhagic risk. The majority of MonaldiCare patients tolerated dabigatran treatment without significant side effects. The efficacy of dabigatran was demonstrated by very low prevalence of ictus/TIA, also when patients underwent electrical AF cardioversion independently of the transesophageal examination.
- Published
- 2015
30. GENDER DIFFERENCES ON CLINICAL OUTCOMES IN PATIENTS UNDERGOING TRANSCATHETER PULMONARY VALVE IMPLANTATION
- Author
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Marzullo, R, Laudadio, R, Solimene, A, Giordano, M, Gaio, G, Cappelli Bigazzi, M, Palladino, T, Sarubbi, B, and Russo, M
- Published
- 2024
- Full Text
- View/download PDF
31. PERCUTANEOUS CLOSURE OF PATENT FORAMEN OVALE AFTER A FAILED DEVICE–CLOSURE ATTEMPT: A HIGH–VOLUME SINGLE CENTRE EXPERIENCE
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Giordano, M, Gaio, G, Marzullo, R, Scognamiglio, G, Altobelli, I, Gaudieri, G, Palladino, M, Cappelli Bigazzi, M, Della Cioppa, N, Golino, P, Sarubbi, B, and Russo, M
- Published
- 2024
- Full Text
- View/download PDF
32. P4003Right atrial function and prognosis in pulmonary arterial hypertension
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D'Alto, M., primary, D'Andrea, A., additional, Di Salvo, G., additional, Scognamiglio, G., additional, Argiento, P., additional, Romeo, E., additional, Di Marco, G.M., additional, Mattera Iacono, A., additional, Sarubbi, B., additional, and Russo, M.G., additional
- Published
- 2017
- Full Text
- View/download PDF
33. P2591Acute fluid loading and prognosis in pulmonary arterial hypertension
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D'Alto, M., primary, Motoji, Y., additional, Romeo, E., additional, Argiento, P., additional, Di Marco, G.M., additional, Mattera Iacono, A., additional, D'Andrea, A., additional, Sarubbi, B., additional, Russo, M.G., additional, and Naeije, R., additional
- Published
- 2017
- Full Text
- View/download PDF
34. Efficacy and safety of dabigatran in a "real-life" population at high thromboembolic and hemorrhagic risk: data from MonaldiCare registry.
- Author
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RUSSO, V., BIANCHI, V., CAVALLARO, C., VECCHIONE, F., DE VIVO, S., SANTANGELO, L., SARUBBI, B., CALABRÒ, P., NIGRO, G., and D'ONOFRIO, A.
- Abstract
OBJECTIVE: Dabigatran is a novel target specific oral anticoagulant for stroke prevention in non valvular atrial fibrillation. Little is still known about its real-world effectiveness and safety in the italian population. Aim of our study was to evaluate the efficacy and safety of dabigatran in a large single-center cohort of "real- life" italian population with non-valvular AF and to compare the results with those obtained from the RE-LY trial and the Medicare study. PATIENTS AND METHODS: We studied a prospective cohor t of 2108 patients (1119 male; mean age 69.4 ± 9.4 years) who started the oral anticoagulant treatment with dabigatran 110 mg twice-daily (DAB 110; N = 1075; 51%) or 150 mg twice-daily (DAB 150; N = 1033; 49%). Follow-up data were obtained trough outpatients visits each 3-6 months for assessing the clinical status, adherence to treatment, occurrence of side effects and major cardiovascular complications. RESULTS: In DAB 150 group the mean age was 64.9 ± 8.8 years, 56.8% of patients was male. CHA2DS2Vasc Score was ≥3 in 94.3% and HASBLED was ≥3 in 59.7%. In DAB 110 group (N = 1075) the mean age was 73.9 ± 7.5 years; 49.5% of patients was male. CHA2DS2Vasc Score was ≥ 3 in 73.4% and HAS-BLED was ≥3 in 87.4% of DAB 110 patients. One patient taking Dabigatran 110 mg bid had ischemic stroke without significantly neurological sequelae. In both groups, no patient experienced hemorrhagic stroke during the follow-up period. 147 patients (6.9%) of MonaldiCare population reported adverse effects from treatment with dabigatran, of whom 121 patients (5.7%) discontinued therapy. We reported one case of subarachnoid hemorrhage (0.05%) in a patient with high thrombo-embolic and high hemorrhagic risk score who was taking dabigatran 150 mg bid and one case (0.05%) of bladder bleeding in a patient who was taking dabigatran 110 mg bid. No major gastrointestinal bleeding was observed in the MonaldiCare population. CONCLUSIONS: MonaldiCare registry showed a safety profile of both dosages of dabigatran regarding major of fatal bleeding in a "real life" single center italian population at high thromboembolic and hemorrhagic risk. The majority of MonaldiCare patients tolerated dabigatran treatment without significant side effects. The efficacy of dabigatran was demonstrated by very low prevalence of ictus/TIA, also when patients underwent electrical AF cardioversion independently of the transesophageal examination. [ABSTRACT FROM AUTHOR]
- Published
- 2015
35. Subcutaneous implantable cardioverter defibrillator in children and adolescents: results from the S-ICD 'Monaldi care' registry
- Author
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Maria Giovanna Russo, Diego Colonna, Salvatore Virno, Anna Correra, Berardo Sarubbi, M D'Alto, Maria Teresa Palladino, Emanuele Romeo, Antonio D'Onofrio, Sarubbi, B., Colonna, D., Correra, A., Romeo, E., D'Alto, M., Palladino, M. T., Virno, S., D'Onofrio, A., and Russo, M. G.
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Adult ,Pediatrics ,medicine.medical_specialty ,Adolescent ,Heart disease ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,Sudden death ,03 medical and health sciences ,Ventricular arrhythmias ,0302 clinical medicine ,Physiology (medical) ,Antibiotic therapy ,medicine ,Humans ,Registries ,030212 general & internal medicine ,Child ,Inappropriate shock ,Arrhythmogenic Right Ventricular Dysplasia ,Subcutaneous implantable cardioverter defibrillator ,business.industry ,Arrhythmias, Cardiac ,Implantable cardioverter-defibrillator ,medicine.disease ,Defibrillators, Implantable ,Arrhythmogenic right ventricular dysplasia ,Death, Sudden, Cardiac ,Treatment Outcome ,Parasternal line ,Cohort ,Implant ,Cardiology and Cardiovascular Medicine ,business ,Transvenous implantable cardioverter defibrillator - Abstract
Background: Implantable cardioverter defibrillators (ICD) are widely accepted therapy in children and adolescents who are survivors of cardiac arrest or for high-risk patients with inheritable channelopathies, cardiomyopathies, or congenital heart disease. Initial experience with subcutaneous ICD (S-ICD) systems has shown a high efficacy in adults. However, the use of S-ICD in children and adolescents implies some specific considerations, as the safety for these patients is unknown and recommendations among physicians may vary widely. Methods: We reviewed the data and studied the indications for S-ICD in children and adolescents and discuss the preliminary clinical experience. Results: From a cohort of 297 patients enrolled in the S-ICD “Monaldi care” registry that encompass all the patients implanted in the Monaldi Hospital of Naples, we considered 21 consecutive children and adolescents (mean age 13.9 years, range 8-18 years, mean body weight 59.3 kg, range 38-100 kg) who underwent S-ICD implant from April 2014 to June 2020. Mean follow-up was 41.9±21.9 months. Only one patient presented, 6 weeks after implantation, skin erosion at the inferior parasternal incision that resolved after antibiotic therapy, without the necessity of any system revision. Two patients experienced appropriate shocks and four inappropriate shocks, due to T wave oversensing or atrial arrhythmia. Only one patient, with arrhythmogenic right ventricular dysplasia, required a system revision after 36 months of the first implantation and then a reintervention with a replacement of the S-ICD by a conventional ICD system. Conclusions: Our experience suggests that the S-ICD device can be used in some children over the age of 8 as well as adults, with a similar rate of unwanted side effects, and early evidence of apparent efficacy.
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- 2021
36. Clinical Manifestations of 22q11.2 Deletion Syndrome
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Emilia Cirillo, Bruno Marino, Augusto Esposito, Paolo Versacci, Annalisa Passariello, Giovanni Signore, Berardo Sarubbi, Martina Caiazza, Anwar Baban, Claudio Pignata, Adelaide Fusco, Emanuele Monda, Fiorella Fratta, Michele Lioncino, Maria Giovanna Russo, Annapaola Cirillo, Giuliana Giardino, Carolina Putotto, Annachiara Maratea, Giuseppe Limongelli, Cirillo, A., Lioncino, M., Maratea, A., Passariello, A., Fusco, A., Fratta, F., Monda, E., Caiazza, M., Signore, G., Esposito, A., Baban, A., Versacci, P., Putotto, C., Marino, B., Pignata, C., Cirillo, E., Giardino, G., Sarubbi, B., Limongelli, G., and Russo, M. G.
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Heart Defects, Congenital ,Pathology ,medicine.medical_specialty ,Long arm ,Marfan Syndrome ,Aortic arch abnormalitie ,DiGeorge syndrome ,DiGeorge Syndrome ,Medicine ,Humans ,Deletion syndrome ,Multiplex ,Di George syndrome ,22q11.2 deletion syndrome ,Aortic arch abnormalities ,Conotruncal abnormalities ,In Situ Hybridization, Fluorescence ,medicine.diagnostic_test ,business.industry ,Genetic disorder ,Karyotype ,General Medicine ,medicine.disease ,Conotruncal abnormalitie ,Karyotyping ,Chromosome Deletion ,Cardiology and Cardiovascular Medicine ,business ,Chromosome 22 ,Fluorescence in situ hybridization ,Human - Abstract
DiGeorge syndrome (DGS), also known as "22q11.2 deletion syndrome" (22q11DS) (MIM # 192430 # 188400), is a genetic disorder caused by hemizygous microdeletion of the long arm of chromosome 22. In the last decades, the introduction of fluorescence in situ hybridization assays, and in selected cases the use of multiplex ligation-dependent probe amplification, has allowed the detection of chromosomal microdeletions that could not be previously identified using standard karyotype analysis. The aim of this review is to address cardiovascular and systemic involvement in children with DGS, provide genotype-phenotype correlations, and discuss their medical management and therapeutic options.
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- 2022
37. A frightening giant QRS complex in a 3-months-old infant
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Anna Correra, Diego Colonna, Annalisa Passariello, Assunta Merola, Berardo Sarubbi, Michela Palma, Emanuele Romeo, Maria Giovanna Russo, Correra, A., Merola, A., Palma, M., Romeo, E., Colonna, D., Passariello, A., Russo, M. G., and Sarubbi, B.
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medicine.medical_specialty ,030204 cardiovascular system & hematology ,QRS ,03 medical and health sciences ,QRS complex ,Electrocardiography ,0302 clinical medicine ,Internal medicine ,medicine ,Flecainide overdosing ,Humans ,Sinus rhythm ,030212 general & internal medicine ,Flecainide ,Therapeutic error ,Toxicity ,business.industry ,Av interval ,Infant ,Anti-Arrhythmia Agent ,Accidental ,Cardiology ,Drug intoxication ,Drug Overdose ,Cardiology and Cardiovascular Medicine ,business ,Anti-Arrhythmia Agents ,medicine.drug ,Human - Abstract
A 3-months-old infant was urgently admitted for drowsiness and lack of appetite started 24 h before. The ECG showed sinus rhythm with a prolonged AV interval (200 ms) and very large QRS complexes (280 ms) due to Flecainide overdosing following incorrectly administration for poor communication between parents resulted in both giving a dose to the infant. Flecainide serum level was 1.2μg/ml, confirming the diagnosis of an accidental drug intoxication. The patient started continue hydration with a close monitoring. Three hours later a significant narrowing of the QRS complex (150 ms) was observed, then over the following 24 h, the QRS almost completely normalized.
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- 2020
38. Troponin T Mutation as a Cause of Left Ventricular Systolic Dysfunction in a Young Patient with Previous Surgical Correction of Aortic Coarctation
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Paolo Calabrò, Santo Dellegrottaglie, Adelaide Fusco, Maria Giovanna Russo, Berardo Sarubbi, Francesco Di Fraia, Giulia Frisso, Giuseppe Limongelli, Federica Verrillo, Roberta Pacileo, Alessandra Scatteia, Emanuele Monda, Marta Rubino, Emanuele Romeo, Martina Caiazza, Federica Amodio, Annapaola Cirillo, Michele Lioncino, Anwar Baban, Caiazza, M., Lioncino, M., Monda, E., Di Fraia, F., Verrillo, F., Pacileo, R., Amodio, F., Rubino, M., Cirillo, A., Fusco, A., Romeo, E., Scatteia, A., Dellegrottaglie, S., Calabro', P., Sarubbi, B., Baban, A., Frisso, G., Russo, M. G., Limongelli, G., and Calabro, P.
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Male ,medicine.medical_specialty ,Heart disease ,TNNT2 ,Mutation, Missense ,Cardiomyopathy ,Coarctation of the aorta ,Magnetic Resonance Imaging, Cine ,Hemodynamics ,Case Report ,030204 cardiovascular system & hematology ,Microbiology ,Biochemistry ,Aortic coarctation ,Ventricular Dysfunction, Left ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Troponin T ,Internal medicine ,medicine ,Humans ,Genetic Predisposition to Disease ,030212 general & internal medicine ,Molecular Biology ,business.industry ,Left ventricular systolic dysfunction ,Dilated cardiomyopathy ,medicine.disease ,QR1-502 ,Pedigree ,medicine.anatomical_structure ,Ventricle ,Cardiology ,business - Abstract
Coarctation of the aorta is a leading cause of morbidity and mortality among adults with congenital heart disease (ACHD). Lifelong surveillance is mandatory to screen for possible long-term cardiovascular events.Left ventricular systolic dysfunction has been reported in association with recoarctation, and association with dilated cardiomyopathy (DCMP) is very rare. Herein, we report the case of a 19-year-old boy with coarctation of the aorta who complained of mild exertional dyspnea. Cardiac magnetic resonance revealed a moderately dilated, hypokinetic left ventricle (LV), with mildly reduced EF (45%), and residual isthmic coarctation was excluded. Genetic tests revealed a heterozygous missense variant in TNNT2 (NM_001001430.2): c.518G>A (p. Arg173Gln). This case highlights the role of careful history taking: a family history of cardiomyopathy should not be overlooked even when the clinical setting seems to suggest a predisposition to hemodynamic factors for LVSD.
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- 2021
39. Consensus Document of the Italian Association of Hospital Cardiologists (ANMCO), Italian Society of Pediatric Cardiology (SICP), and Italian Society of Gynaecologists and Obstetrics (SIGO): pregnancy and congenital heart diseases
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Elsa Viora, Giovanna Geraci, Silvia Favilli, Massimo Chessa, Maria Giovanna Russo, Marco Bonvicini, Sebastiano Bianca, Marco Poli, Giuseppe Canzone, Gabriele Egidy Assenza, Rachele Adorisio, Maria Gabriella Carmina, Maurizio Mongiovì, Gabriella Agnoletti, Marcello Campisi, Chiara Barone, Berardo Sarubbi, Francesca Comoglio, Annalisa Alaimo, Innocenzo Bianca, Michele Massimo Gulizia, Bianca, I., Geraci, G., Gulizia, M. M., Assenza, G. E., Barone, C., Campisi, M., Alaimo, A., Adorisio, R., Comoglio, F., Favilli, S., Agnoletti, G., Carmina, M. G., Chessa, M., Sarubbi, B., Mongiovi, M., Russo, M. G., Bianca, S., Canzone, G., Bonvicini, M., Viora, E., and Poli, M.
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medicine.medical_specialty ,Pediatrics ,Heart disease ,Population ,Reproductive age ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Obstetrics and gynaecology ,Pregnancy ,medicine ,030212 general & internal medicine ,education ,Cardiac complication ,Congenital heart disease ,Risk assessment ,education.field_of_study ,business.industry ,Articles ,Cardiovascular disease ,medicine.disease ,Cardiac surgery ,Family medicine ,Cardiac complications ,Cardiology and Cardiovascular Medicine ,business ,Delivery ,Pediatric cardiology - Abstract
The success of cardiac surgery over the past 50 years has increased numbers and median age of survivors with congenital heart disease (CHD). Adults now represent two-thirds of patients with CHD; in the USA alone the number is estimated to exceed 1 million. In this population, many affected women reach reproductive age and wish to have children. While in many CHD patients pregnancy can be accomplished successfully, some special situations with complex anatomy, iatrogenic or residual pathology are associated with an increased risk of severe maternal and fetal complications. Pre-conception counselling allows women to come to truly informed choices. Risk stratification tools can also help high-risk women to eventually renounce to pregnancy and to adopt safe contraception options. Once pregnant, women identified as intermediate or high risk should receive multidisciplinary care involving a cardiologist, an obstetrician and an anesthesiologist with specific expertise in managing this peculiar medical challenge. This document is intended to provide cardiologists working in hospitals where an Obstetrics and Gynecology Department is available with a streamlined and practical tool, useful for them to select the best management strategies to deal with a woman affected by CHD who desires to plan pregnancy or is already pregnant.
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- 2017
40. A 'long-standing' malpositioned pacing lead. Long-term follow-up after extraction
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Enrico Melillo, Michele D'Alto, Berardo Sarubbi, Giancarlo Scognamiglio, Maria Giovanna Russo, Flavia Fusco, Sarubbi, B., Scognamiglio, G., Fusco, F., Melillo, E., D'Alto, M., and Russo, M. G.
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Pulmonary and Respiratory Medicine ,Pacemaker, Artificial ,medicine.medical_specialty ,Long term follow up ,Heart Ventricles ,lcsh:Medicine ,surgical extraction ,Follow-Up Studie ,Heart Ventricle ,Electrocardiography ,Mitral valve ,Surgical extraction ,medicine ,Humans ,Atrioventricular Block ,Child ,Lead (electronics) ,Device Removal ,pacemaker malposition ,Atrial Septum ,Medical Errors ,business.industry ,lcsh:R ,Cardiac Pacing, Artificial ,Medical Error ,Electrodes, Implanted ,Surgery ,Malpositioned ,medicine.anatomical_structure ,Echocardiography ,Ventricle ,Mitral Valve ,Female ,Radiography, Thoracic ,Implant ,Cardiology and Cardiovascular Medicine ,business ,Lateral wall ,Congenital AV block ,Human ,Follow-Up Studies - Abstract
Transvenous pacemaker (PM) catheters can be unintentionally placed in the left ventricle (LV) during the implantation procedure. An 8-year-old girl was discovered with a malpositioned pm wire, seven years after the implant. Trans-thoracic echocardiogram revealed the lead traversing the inter-atrial septum, crossing the mitral valve and embedded in the basal lateral wall of the LV. This is a report of a 14-year long follow-up after the surgical extraction of the malpositioned PM lead. come easier. Although nowadays a transvenous lead can be placed in children, there is a greater risk of complication in small patients [3]. One extremely rare complication associated with transvenous PM implantation is the inadvertent positioning of pacing lead in the left ventricle [4]. The greater risks depend on the delay of diagnosis of lead malpositions. This report concerns a case of long standing malpositioned PM wire in a paediatric patient and the successive long term follow up after the successful surgical extraction.
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- 2018
41. Subcutaneous implantable cardioverter defibrillator implantation. An analysis of Italian clinical practice and its evolution
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Ennio Pisano, Maurizio Landolina, Carmelo La Greca, Gerardo Nigro, Berardo Sarubbi, Maria Grazia Bongiorni, Paolo De Filippo, Paolo Pieragnoli, M. Viscusi, Pietro Palmisano, Alessandro Capucci, Giovanni Luca Botto, Antonio D'Onofrio, Mariolina Lovecchio, Sergio Valsecchi, Federico Migliore, Mauro Biffi, Simone Sala, Massimo Giammaria, Pietro Francia, Giovanni Bisignani, D'Onofrio, A., Pieragnoli, P., Biffi, M., Nigro, G., Migliore, F., Francia, P., De Filippo, P., Capucci, A., Botto, G. L., Giammaria, M., Palmisano, P., Pisano, E., Bisignani, G., La Greca, C., Sarubbi, B., Sala, S., Viscusi, M., Landolina, M., Lovecchio, M., Valsecchi, S., and Bongiorni, M. G.
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Registrie ,Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Cardiomyopathy ,Arrhythmias ,030204 cardiovascular system & hematology ,Implantable defibrillator ,Electrocardiography ,03 medical and health sciences ,Subcutaneous Tissue ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,In patient ,Subcutaneou ,Registries ,030212 general & internal medicine ,Secondary prevention ,Ejection fraction ,business.industry ,Subcutaneous ,Arrhythmias, Cardiac ,Dilated cardiomyopathy ,Middle Aged ,medicine.disease ,Implantable cardioverter-defibrillator ,Defibrillators, Implantable ,Clinical Practice ,Treatment Outcome ,Italy ,Cardiology ,defibrillation test ,implantable defibrillator ,subcutaneous ,adult ,arrhythmias, cardiac ,defibrillators ,implantable ,electrocardiography ,female ,humans ,italy ,male ,middle aged ,registries ,treatment outcome ,subcutaneous tissue ,Female ,Defibrillation test ,Implantable ,Cardiology and Cardiovascular Medicine ,business ,Cardiac ,Human ,Defibrillators - Abstract
Background: The subcutaneous implantable cardioverter defibrillator (S-ICD) is a relatively novel alternative to the transvenous ICD for the treatment of life-threatening ventricular arrhythmias, and is currently used in the clinical practice of several centers. The aim of this analysis was to describe current Italian practice regarding S-ICD implantation and its evolution over the years. Methods: We analyzed 607 consecutive patients (78% male, 48 ± 16 years) who underwent S-ICD implantation in 39 Italian centers from 2013 to 2017. Results: Structural cardiomyopathy was present in 78% of patients and 30% of patients received their device for secondary prevention. The proportion of patients with dilated cardiomyopathy and with left ventricular ejection fraction ≤35% increased from ≤2014 to 2017 (from 38% to 58%, from 33% to 53%, respectively; both p < 0.05). Almost all procedures (97%) were performed in electrophysiology laboratories. Over the last 4 years, the 2-incision implantation technique has been widely adopted, with sub- or inter-muscular positioning of the generator, under local anesthesia or deep sedation (≤2014 versus 2017: all p < 0.001). Defibrillation testing was performed in 81% of patients. Shock energy of ≤65 J was successful in 93.9% of patients and the overall cardioversion success rate at ≤80 J was 99.8%. Conclusions: Our analysis confirmed that the S-ICD continues to be preferentially used in specific patients (younger, less frequently with dilated cardiomyopathy and low ejection fraction.). Nonetheless, we noted a trend toward the wider use of S-ICD in patients with dilated cardiomyopathy and systolic dysfunction over the years. Novel approaches have been adopted while the acute efficacy of the system has remained stably high.
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- 2018
42. Right atrial function and prognosis in idiopathic pulmonary arterial hypertension
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Maria Giovanna Russo, Berardo Sarubbi, Emanuele Romeo, Michele D'Alto, Antonello D'Andrea, Giovanni Di Salvo, Giovanni Maria Di Marco, Giancarlo Scognamiglio, Agostino Mattera Iacono, Paola Argiento, Eduardo Bossone, D'Alto, M, D'Andrea, A, Di Salvo, G, Scognamiglio, G, Argiento, P, Romeo, E, Di Marco, Gm, Iacono, Am, Bossone, E, Sarubbi, B, Russo, Mg, D'Alto, Michele, D'Andrea, Antonello, DI SALVO, Giovanni, Scognamiglio, Giancarlo, Argiento, Paola, Romeo, Emanuele, Di Marco, Giovanni Maria, Mattera Iacono, Agostino, Bossone, Eduardo, Sarubbi, Berardo, and Russo, Maria Giovanna
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Adult ,Male ,medicine.medical_specialty ,Cardiac output ,Prognosi ,Hypertension, Pulmonary ,Cardiac index ,Atrial Function, Right ,030204 cardiovascular system & hematology ,Doppler echocardiography ,Pulmonary arterial hypertension ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,030212 general & internal medicine ,Prospective Studies ,Echocardiography ,Prognosis ,Right atrium ,Aged ,Female ,Follow-Up Studies ,Middle Aged ,Pulmonary wedge pressure ,medicine.diagnostic_test ,business.industry ,Hazard ratio ,Central venous pressure ,Pulmonary ,Atrial Function ,medicine.disease ,Pulmonary hypertension ,Right ,medicine.anatomical_structure ,Hypertension ,Vascular resistance ,Cardiology ,Cardiology and Cardiovascular Medicine ,business - Abstract
Aim: To determine whether right atrial (RA) function has prognostic value in patients with idiopathic pulmonary arterial hypertension (PAH).Methods and results: Overall, 104 patients (70 female, mean age 58 +/- 13 years) with idiopathic PAH underwent standard Doppler echocardiography and strain and strain rate (SR) analysis before right heart catheterization. At a mean follow-up of 22 +/- 7 months, 30 patients (29%) had clinical worsening. On Cox multivariable proportional-hazards regression analysis, RA reservoir function measured as peak longitudinal SR (hazard ratio [HR] 0.5; P < 0.0001), RA area (HR 1.2; P < 0.01), right ventricular (RV) SR (HR 0.6; P < 0.0001), cardiac index (HR 0.79; P < 0.01), and mixed venous oxygen saturation (HR 0.82; P < 0.01) were found to be independent correlates of cardiac events. A RA SR reservoir cut-off value of
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- 2017
43. A simple echocardiographic score for the diagnosis of pulmonary vascular disease in heart failure
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Maria Giovanna Russo, Gaetano Rea, Emanuele Romeo, Antonello D'Andrea, Paola Argiento, Robert Naeije, Adriana Pavelescu, Berardo Sarubbi, Eduardo Bossone, Michele D'Alto, Agostino Mattera Iacono, Giovanni Maria Di Marco, D'Alto, M, Romeo, E, Argiento, P, Pavelescu, A, D'Andrea, A, Di Marco, Gm, Iacono, Am, Sarubbi, B, Rea, G, Bossone, E, Russo, Mg, and Naeije, R
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medicine.medical_specialty ,Framingham Risk Score ,business.industry ,Vascular disease ,medicine.medical_treatment ,General Medicine ,030204 cardiovascular system & hematology ,medicine.disease ,Inferior vena cava ,Pulmonary hypertension ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,030228 respiratory system ,medicine.vein ,Ventricle ,Internal medicine ,Heart failure ,medicine ,Cardiology ,Cardiology and Cardiovascular Medicine ,Pulmonary wedge pressure ,business ,Cardiac catheterization - Abstract
AIMS A simple echocardiographic score was designed for diagnosing precapillary vs postcapillary pulmonary hypertension and for discriminating between isolated postcapillary pulmonary hypertension (Ipc-PH) and combined precapillary and postcapillary pulmonary hypertension (Cpc-PH). METHODS The score comprised 7 points (2 for E/e' ratio ≤10, 2 for a dilated non-collapsible inferior vena cava, 1 for a left ventricular eccentricity index ≥1.2, 1 for a right-to-left heart chamber dimension ratio >1 and 1 for the right ventricle forming the heart apex) and was applied to 230 consecutive patients referred for evaluation of pulmonary hypertension. RESULTS Precapillary pulmonary hypertension and postcapillary pulmonary hypertension were diagnosed in 160 and 70 patients, respectively. In the latter, Ipc-PH was found in 51 and Cpc-PH in 19. The echo score was higher in precapillary vs postcapillary pulmonary hypertension patients (4.2 ± 1.7 vs 1.6 ± 1.7, P
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- 2017
44. Clinical Relevance of Fluid Challenge in Patients Evaluated for Pulmonary Hypertension
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Anna Correra, Paola Argiento, Berardo Sarubbi, Antonello D'Andrea, Yoshiki Motoji, Emanuele Romeo, Michele D'Alto, Agostino Mattera Iacono, Giovanni Maria Di Marco, Rosaria Barracano, Robert Naeije, Maria Giovanna Russo, Gaetano Rea, D'Alto, M., Romeo, E., Argiento, P., Motoji, Y., Correra, A., Di Marco, G. M., Iacono, A. M., Barracano, R., D'Andrea, A., Rea, G., Sarubbi, B., Russo, M. G., and Naeije, R.
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Pulmonary and Respiratory Medicine ,Adult ,Male ,medicine.medical_specialty ,Cardiac Catheterization ,Pulmonary Circulation ,Hypertension, Pulmonary ,Hemodynamics ,heart failure ,Reproducibility of Result ,030204 cardiovascular system & hematology ,Sodium Chloride ,Critical Care and Intensive Care Medicine ,heart catheterization ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine.artery ,pulmonary hypertension ,medicine ,Humans ,Prospective Studies ,Infusions, Intravenou ,Pulmonary Wedge Pressure ,Infusions, Intravenous ,Pulmonary wedge pressure ,Fluid Shifts ,Aged ,business.industry ,Central venous pressure ,Reproducibility of Results ,Fluid Shift ,Middle Aged ,medicine.disease ,Pulmonary hypertension ,fluid challenge ,Prospective Studie ,medicine.anatomical_structure ,030228 respiratory system ,Heart failure ,Heart catheterization ,Pulmonary artery ,Vascular resistance ,Cardiology ,Female ,Vascular Resistance ,Cardiology and Cardiovascular Medicine ,business ,Human - Abstract
Background Fluid challenge may help in the differential diagnosis between pre- and postcapillary pulmonary hypertension (PH). However, the test is still in need of standardization and better defined clinical relevance. Methods Two hundred twelve patients referred for PH underwent a right-sided heart catheterization with measurements before and after rapid infusion of 7mL/kg of saline. PH was defined as mean pulmonary artery pressure≥ 25mmHg, and postcapillary PH was defined as pulmonary artery wedge pressure (PAWP) > 15mmHg. An increase in PAWP≥ 18mmHg was considered diagnostic for postcapillary PH. At baseline, 66 patients received a diagnosis of no PH; 22, of postcapillary PH; and 124, of precapillary PH (mostly pulmonary arterial hypertension). Results After fluid challenge, five of 66 patients with no PH (8%) and eight of 124 with precapillary PH (6%) had the diagnosis reclassified as postcapillary PH. Fluid challenge was associated with an increase in PAWP by 7 ± 2mmHg in postcapillary PH and 3 ± 1mmHg in both precapillary PH and no-PH groups. Between-group differences were significant, but there was overlap. There were no adverse events related to fluid challenge. Prediction bands calculated from quadratic fits of the PAWP responses in pooled control subjects with no PH and patients with precapillary PH helped confirm 18mmHg as the cutoff for diagnosing postcapillary PH. Conclusions Fluid challenge with 7mL/kg saline increases PAWP, more in postcapillary than in precapillary PH or in control subjects with no PH. A cutoff value of 18mmHg allows reclassification of 6%to 8%of patients with precapillary PH or normal hemodynamic characteristics at baseline.
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- 2017
45. Echocardiographic assessment of right ventricular contractile reserve in healthy subjects
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Giovanni Maria Di Marco, Maria Giovanna Russo, Adriana Pavelescu, Antonello D'Andrea, Robert Naeije, Paola Argiento, Michele D'Alto, Anna Correra, Berardo Sarubbi, Emanuele Romeo, D'Alto, M., Pavelescu, A., Argiento, P., Romeo, E., Correra, A., Di Marco, G. M., D'Andrea, A., Sarubbi, B., Russo, M. G., and Naeije, R.
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Adult ,Male ,medicine.medical_specialty ,Systole ,Heart Ventricles ,030204 cardiovascular system & hematology ,Heart Ventricle ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,medicine.artery ,Internal medicine ,Echocardiography, Stre ,medicine ,Humans ,echocardiography ,Radiology, Nuclear Medicine and imaging ,Prospective Studies ,Pulmonary Wedge Pressure ,Prospective cohort study ,Peak exercise ,Exercise Tolerance ,business.industry ,Healthy subjects ,Stroke Volume ,Stroke volume ,Middle Aged ,medicine.disease ,Pulmonary hypertension ,Healthy Volunteer ,Myocardial Contraction ,Healthy Volunteers ,right ventricular function ,Prospective Studie ,Blood pressure ,030228 respiratory system ,Pulmonary artery ,Cardiology ,Exercise Test ,Ventricular Function, Right ,Functional significance ,Female ,Cardiology and Cardiovascular Medicine ,business ,Echocardiography, Stress ,Human - Abstract
Background: Exercise-induced increase in pulmonary artery systolic pressure (PASP) as a possible measure of right ventricular (RV) contractile reserve has been shown to predict survival in severe pulmonary hypertension. However, RV contractile reserve can also be measured by changes in stroke volume (SV), tricuspid annular plane systolic excursion (TAPSE), or tricuspid annular systolic velocity (S'). The limits of normal values and the functional significance of these changes in healthy subjects are not well known. Methods: In this prospective study, 90 healthy subjects (45 male, mean age 39 ± 13years) underwent exercise stress echocardiography with measurement of TAPSE, S', TAPSE/PASP, SV, and PASP at rest and peak exercise. Maximum and minimum normal values were reported for all indices. Results: Normal values of exercise-induced changes (Δ) were 4 to 10mm for TAPSE, 6 to 14cm/s for S', 12 to 57mm Hg for PASP, 0 to 96mL for SV, and −1.2 to 0mm/mm Hg for TAPSE/PASP. At peak exercise, women showed lower ΔTAPSE/PASP, ΔPASP, ΔS', and ΔSV, but higher TAPSE/PASP than men. Aging was associated with decreased ΔTAPSE/PASP, ΔTAPSE, ΔS', ΔPASP, and ΔSV. In addition, ΔS', ΔTAPSE/PASP, ΔPASP, and ΔSV, but not ΔTAPSE, were directly correlated with maximum workload. Conclusions: Our results provide age- and sex-related limits of normal for RV contractile reserve as assessed by exercise stress echocardiography and demonstrate that RV systolic function indices (PASP, TAPSE, S', and TAPSE/PASP) correlate with maximum exercise capacity.
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- 2017
46. A Very Late Life-Threatening Complication After Percutaneous Closure of an Atrial Septal Defect
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Maria Giovanna Russo, Gianantonio Nappi, Berardo Sarubbi, Giancarlo Scognamiglio, Andrea Spadafora, Diego Colonna, Giuseppe Santoro, Rosaria Barracano, Agostino Mattera Iacono, Scognamiglio, G., Barracano, R., Colonna, D., Mattera Iacono, A., Santoro, G., Spadafora, A., Nappi, G., Russo, M. G., and Sarubbi, B.
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Male ,Cardiac Catheterization ,medicine.medical_specialty ,Time Factors ,Percutaneous ,Time Factor ,Septal Occluder Device ,Population ,Septum secundum ,030204 cardiovascular system & hematology ,Asymptomatic ,Heart Septal Defects, Atrial ,Follow-Up Studie ,Blood Vessel Prosthesis Implantation ,Young Adult ,03 medical and health sciences ,Aortic aneurysm ,Imaging, Three-Dimensional ,Postoperative Complications ,0302 clinical medicine ,Internal medicine ,Humans ,Cardiac Surgical Procedure ,Medicine ,030212 general & internal medicine ,Cardiac Surgical Procedures ,education ,Heart septal defect ,education.field_of_study ,Aortic Aneurysm, Thoracic ,business.industry ,medicine.disease ,Surgery ,Cardiothoracic surgery ,Cardiology ,medicine.symptom ,Tomography, X-Ray Computed ,Cardiology and Cardiovascular Medicine ,business ,Complication ,Echocardiography, Transesophageal ,Follow-Up Studies ,Human - Abstract
Percutaneous closure is widely recognized as the first therapeutic option in the majority of cases of secundum atrial septal defect (ASD) because of its high effectiveness and safety. Nonetheless, with the progressive increase of implanted devices and follow-up duration, several adverse events, some of them potentially life-threatening, have been reported. We report the case of an asymptomatic aortic erosion that occurred 13 years after the procedure. The main feature of our case is the very late occurrence of a life-threatening asymptomatic complication of ASD percutaneous closure, which should prompt lifelong surveillance in this population.
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- 2017
47. Reply to usage of NobleStitch EL.
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Giordano M, Gaio G, Marzullo R, Scognamiglio G, Altobelli I, Russo MG, and Sarubbi B
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- Humans
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- 2024
- Full Text
- View/download PDF
48. Progression, Management, and Outcome of Aortic Valve Stenosis in Systemic Sclerosis: A Case Series.
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Vergara A, Orlando A, Caiazza E, Vettori S, Cuomo G, Argiento P, Romeo E, Franzese R, Sarubbi B, and D'Alto M
- Abstract
Background: In systemic sclerosis (SSc), cardiac involvement is frequent, heterogeneous, and related to a poor prognosis. Due to a longer life expectancy, the development of degenerative aortic stenosis (AS) is not uncommon. The aim of this article is to report the characteristics of AS in SSc, analyzing the rate of progression, the management, and the outcome., Methods: This is a case series conducted at the Department of Cardiology of Monaldi Hospital, Naples, Italy., Results: From January 2007 to December 2022, we analyzed 234 patients with SSc. Ten/234 patients (4.3%) showed severe AS and were included in the analysis (age 75.5 years [IQR 58-84], nine females). Nine had limited and one diffuse SSc. Two patients were in NHYA/WHO II and eight in NYHA/WHO III. All had degenerative three-leaflet AS. Two patients showed severe AS at the first evaluation, and eight developed severe AS during the follow-up, with a time progression from moderate to severe AS of 3.2 ± 1.1 years (progression rate -0.190 ± 0.012 cm
2 /year for aortic valve area, 8.6 ± 6.1 mmHg/year for mean aortic gradient, 16 ± 7 mmHg/year for peak aortic gradient, and 0.5 ± 0.3 m/s/year for aortic peak velocity). Seven out of 10 patients underwent transcatheter aortic valve implantation (TAVI), one underwent surgical aortic valve replacement (SAVR), one was left untreated, and one was on a waiting list for TAVI. No major complications after TAVI or SAVR occurred. At a mean follow-up of 5.9 ± 3.9 years, eight patients are alive and two died., Conclusion: Severe AS is a relevant cardiac complication of SSc and must be considered in the screening and during the follow-up. Its rapid progression rate may tentatively be due to autoimmunity, degenerative burden, and chronic inflammation.- Published
- 2024
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49. Prognostic Significance of Hemodynamics in Patients With Transposition of the Great Arteries and Systemic Right Ventricle.
- Author
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Aldweib N, Deghani P, Broberg CS, van Dissel A, Altibi A, Wong J, Baker D, Gindi S, Khairy P, Opotowsky AR, Shah S, Magalski A, Cramer J, Kauling RM, Dellborg M, Krieger EV, Yeung E, Roos-Hesselink J, Aboulhosn J, Nicolarsen J, Masha L, Gallego P, Celermajer DS, Kay J, Vonder Muhll I, Jameson SM, O'Donnell C, Fusco F, John AS, Macon C, Antonova P, Cotts T, Sarubbi B, Rodriguez F 3rd, DeZorzi C, Jayadeva PS, Kuo M, Kutty S, Gupta T, Burchill LJ, Rodriguez Monserrate CP, Lubert AM, Grewal J, Pylypchuk S, Belkin MN, and Wilson WM
- Subjects
- Humans, Male, Female, Retrospective Studies, Adult, Prognosis, Middle Aged, Ventricular Function, Right physiology, Pulmonary Wedge Pressure physiology, Transposition of Great Vessels physiopathology, Transposition of Great Vessels surgery, Hemodynamics physiology, Cardiac Catheterization, Heart Ventricles physiopathology, Heart Ventricles diagnostic imaging
- Abstract
Background: Patients with transposition of the great arteries (TGA) and systemic right ventricle often confront significant adverse cardiac events. The prognostic significance of invasive hemodynamic parameters in this context remains uncertain. Our hypothesis is that the aortic pulsatility index and hemodynamic profiling utilizing invasive measures provide prognostic insights for patients with TGA and a systemic right ventricle., Methods: This retrospective multicenter cohort study encompasses adults with TGA and a systemic right ventricle who underwent cardiac catheterization. Data collection, spanning from 1994 to 2020, encompasses clinical and hemodynamic parameters, including measured and calculated values such as pulmonary capillary wedge pressure, aortic pulsatility index, and cardiac index. Pulmonary capillary wedge pressure and cardiac index values were used to establish 4 distinct hemodynamic profiles. A pulmonary capillary wedge pressure of ≥15 mm Hg indicated congestion, termed wet, while a cardiac index <2.2 L/min per m
2 signified inadequate perfusion, labeled cold. The primary outcome comprised a composite of all-cause death, heart transplantation, or the requirement for mechanical circulatory support., Results: Of 1721 patients with TGA, 242 individuals with available invasive hemodynamic data were included. The median follow-up duration after cardiac catheterization was 11.4 (interquartile range, 7.5-15.9) years, with a mean age of 38.5±10.8 years at the time of cardiac catheterization. Among hemodynamic parameters, an aortic pulsatility index <1.5 emerged as a robust predictor of the primary outcome, with adjusted hazard ratios of 5.90 (95% CI, 3.01-11.62; P <0.001). Among the identified 4 hemodynamic profiles, the cold/wet profile was associated with the highest risk for the primary outcome, with an adjusted hazard ratio of 3.83 (95% CI, 1.63-9.02; P <0.001)., Conclusions: A low aortic pulsatility index (<1.5) and the cold/wet hemodynamic profile are linked with an elevated risk of adverse long-term cardiac outcomes in patients with TGA and systemic right ventricle., Competing Interests: None.- Published
- 2024
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50. Antiarrhythmic therapy for narrow QRS supraventricular tachyarrhythmias in newborns and infants in the first year of life: Potent tools to be handled with care.
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Ciriello GD, Sorice D, Orlando A, Papaccioli G, Colonna D, Correra A, Romeo E, Esposito R, De Marco M, Diana V, Giordano M, Barrile LS, Russo MG, and Sarubbi B
- Abstract
Supraventricular tachyarrhythmias pose a significant challenge in neonates and infants, particularly within the first year of life, where prompt and effective management is crucial. By synthesizing available evidence and clinical experience, this review aims to provide a comprehensive overview of antiarrhythmic therapy in this vulnerable population, with a focus on narrow QRS supraventricular tachyarrhythmias. This review examines the current understanding of supraventricular tachyarrhythmia management and discusses the challenges associated with antiarrhythmic therapy in newborns and infants during the critical first year of life, evaluating the efficacy and safety of various antiarrhythmic agents commonly utilized in this population, including dosing considerations, adverse effects, and strategies for acute management and prophylactic long-term antiarrhythmic treatment., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Indian Heart Rhythm Society. Published by Elsevier B.V. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
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