201 results on '"Sandi C"'
Search Results
2. Dropout from exercise trials among cancer survivors : An individual patient data meta-analysis from the POLARIS study
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Western, Benedikte, Ivarsson, Andreas, Vistad, Ingvild, Demmelmaier, Ingrid, Aaronson, Neil K., Radcliffe, Gillian, van Beurden, Marc, Bohus, Martin, Courneya, Kerry S., Daley, Amanda J., Galvão, Daniel A., Garrod, Rachel, Goedendorp, Martine M., Griffith, Kathleen A., van Harten, Wim H., Hayes, Sandi C., Herrero-Roman, Fernando, Hiensch, Anouk E., Irwin, Melinda L., James, Erica, Kenkhuis, Marlou-Floor, Kersten, Marie José, Knoop, Hans, Lucia, Alejandro, May, Anne M., Mcconnachie, Alex, van Mechelen, Willem, Mutrie, Nanette, Newton, Robert U., Nollet, Frans, Oldenburg, Hester S., Plotnikoff, Ron, Schmidt, Martina E., Schmitz, Katie H., Schulz, Karl-Heinz, Short, Camille E., Sonke, Gabe S., Steindorf, Karen, Stuiver, Martijn M., Taaffe, Dennis R., Thorsen, Lene, Velthuis, Miranda J., Wenzel, Jennifer, Winters-Stone, Kerri M., Wiskemann, Joachim, Berntsen, Sveinung, Buffart, Laurien M., Western, Benedikte, Ivarsson, Andreas, Vistad, Ingvild, Demmelmaier, Ingrid, Aaronson, Neil K., Radcliffe, Gillian, van Beurden, Marc, Bohus, Martin, Courneya, Kerry S., Daley, Amanda J., Galvão, Daniel A., Garrod, Rachel, Goedendorp, Martine M., Griffith, Kathleen A., van Harten, Wim H., Hayes, Sandi C., Herrero-Roman, Fernando, Hiensch, Anouk E., Irwin, Melinda L., James, Erica, Kenkhuis, Marlou-Floor, Kersten, Marie José, Knoop, Hans, Lucia, Alejandro, May, Anne M., Mcconnachie, Alex, van Mechelen, Willem, Mutrie, Nanette, Newton, Robert U., Nollet, Frans, Oldenburg, Hester S., Plotnikoff, Ron, Schmidt, Martina E., Schmitz, Katie H., Schulz, Karl-Heinz, Short, Camille E., Sonke, Gabe S., Steindorf, Karen, Stuiver, Martijn M., Taaffe, Dennis R., Thorsen, Lene, Velthuis, Miranda J., Wenzel, Jennifer, Winters-Stone, Kerri M., Wiskemann, Joachim, Berntsen, Sveinung, and Buffart, Laurien M.
- Abstract
Introduction The number of randomized controlled trials (RCTs) investigating the effects of exercise among cancer survivors has increased in recent years; however, participants dropping out of the trials are rarely described. The objective of the present study was to assess which combinations of participant and exercise program characteristics were associated with dropout from the exercise arms of RCTs among cancer survivors. Methods This study used data collected in the Predicting OptimaL cAncer RehabIlitation and Supportive care (POLARIS) study, an international database of RCTs investigating the effects of exercise among cancer survivors. Thirty-four exercise trials, with a total of 2467 patients without metastatic disease randomized to an exercise arm were included. Harmonized studies included a pre and a posttest, and participants were classified as dropouts when missing all assessments at the post-intervention test. Subgroups were identified with a conditional inference tree. Results Overall, 9.6% of the participants dropped out. Five subgroups were identified in the conditional inference tree based on four significant associations with dropout. Most dropout was observed for participants with BMI >28.4 kg/m2, performing supervised resistance or unsupervised mixed exercise (19.8% dropout) or had low-medium education and performed aerobic or supervised mixed exercise (13.5%). The lowest dropout was found for participants with BMI >28.4 kg/m2 and high education performing aerobic or supervised mixed exercise (5.1%), and participants with BMI ≤28.4 kg/m2 exercising during (5.2%) or post (9.5%) treatment. Conclusions There are several systematic differences between cancer survivors completing and dropping out from exercise trials, possibly affecting the external validity of exercise effects.
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- 2024
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3. Dropout from exercise trials among cancer survivors-An individual patient data meta-analysis from the POLARIS study
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Epi Kanker Team B, Cancer, Epi Kanker, JC onderzoeksprogramma Kanker, Western, Benedikte, Ivarsson, Andreas, Vistad, Ingvild, Demmelmaier, Ingrid, Aaronson, Neil K, Radcliffe, Gillian, van Beurden, Marc, Bohus, Martin, Courneya, Kerry S, Daley, Amanda J, Galvão, Daniel A, Garrod, Rachel, Goedendorp, Martine M, Griffith, Kathleen A, van Harten, Wim H, Hayes, Sandi C, Herrero-Roman, Fernando, Hiensch, Anouk E, Irwin, Melinda L, James, Erica, Kenkhuis, Marlou-Floor, Kersten, Marie José, Knoop, Hans, Lucia, Alejandro, May, Anne M, McConnachie, Alex, van Mechelen, Willem, Mutrie, Nanette, Newton, Robert U, Nollet, Frans, Oldenburg, Hester S, Plotnikoff, Ron, Schmidt, Martina E, Schmitz, Katie H, Schulz, Karl-Heinz, Short, Camille E, Sonke, Gabe S, Steindorf, Karen, Stuiver, Martijn M, Taaffe, Dennis R, Thorsen, Lene, Velthuis, Miranda J, Wenzel, Jennifer, Winters-Stone, Kerri M, Wiskemann, Joachim, Berntsen, Sveinung, Buffart, Laurien M, Epi Kanker Team B, Cancer, Epi Kanker, JC onderzoeksprogramma Kanker, Western, Benedikte, Ivarsson, Andreas, Vistad, Ingvild, Demmelmaier, Ingrid, Aaronson, Neil K, Radcliffe, Gillian, van Beurden, Marc, Bohus, Martin, Courneya, Kerry S, Daley, Amanda J, Galvão, Daniel A, Garrod, Rachel, Goedendorp, Martine M, Griffith, Kathleen A, van Harten, Wim H, Hayes, Sandi C, Herrero-Roman, Fernando, Hiensch, Anouk E, Irwin, Melinda L, James, Erica, Kenkhuis, Marlou-Floor, Kersten, Marie José, Knoop, Hans, Lucia, Alejandro, May, Anne M, McConnachie, Alex, van Mechelen, Willem, Mutrie, Nanette, Newton, Robert U, Nollet, Frans, Oldenburg, Hester S, Plotnikoff, Ron, Schmidt, Martina E, Schmitz, Katie H, Schulz, Karl-Heinz, Short, Camille E, Sonke, Gabe S, Steindorf, Karen, Stuiver, Martijn M, Taaffe, Dennis R, Thorsen, Lene, Velthuis, Miranda J, Wenzel, Jennifer, Winters-Stone, Kerri M, Wiskemann, Joachim, Berntsen, Sveinung, and Buffart, Laurien M
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- 2024
4. Ciujung river basin flood risk assessment due to climate change and its countermeasure.
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Putriasri, A E, Eliasta, L, Amatullah, S I, Sandi, C, Pahlevi, A R, Hikmat, S N, Jaya, I, Kosasih, B, Rahmawati, A, and Hermawan, Y
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- 2024
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5. Epigenome-wide DNA methylation in externalizing behaviours: A review and combined analysis.
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Meijer, M., Franke, B., Sandi, C., Klein, M., Meijer, M., Franke, B., Sandi, C., and Klein, M.
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01 februari 2023, Item does not contain fulltext, DNA methylation (DNAm) is one of the most frequently studied epigenetic mechanisms facilitating the interplay of genomic and environmental factors, which can contribute to externalizing behaviours and related psychiatric disorders. Previous epigenome-wide association studies (EWAS) for externalizing behaviours have been limited in sample size, and, therefore, candidate genes and biomarkers with robust evidence are still lacking. We 1) performed a systematic literature review of EWAS of attention-deficit/hyperactivity disorder (ADHD)- and aggression-related behaviours conducted in peripheral tissue and cord blood and 2) combined the most strongly associated DNAm sites observed in individual studies (p < 10(-3)) to identify candidate genes and biological systems for ADHD and aggressive behaviours. We observed enrichment for neuronal processes and neuronal cell marker genes for ADHD. Astrocyte and granulocytes cell markers among genes annotated to DNAm sites were relevant for both ADHD and aggression-related behaviours. Only 1 % of the most significant epigenetic findings for ADHD/ADHD symptoms were likely to be directly explained by genetic factors involved in ADHD. Finally, we discuss how the field would greatly benefit from larger sample sizes and harmonization of assessment instruments.
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- 2023
6. Epigenetics in externalizing behaviours: Linking the environment and genetics as a key to understanding externalizing behaviours across species
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Franke, B., Sandi, C., Klein, M., Meijer, M., Franke, B., Sandi, C., Klein, M., and Meijer, M.
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Radboud University, 07 maart 2023, Promotores : Franke, B., Sandi, C. Co-promotor : Klein, M., Contains fulltext : 289574.pdf (Publisher’s version ) (Closed access)
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- 2023
7. Effects of paternal and peripubertal stress on aggression, anxiety, and metabolic alterations in the lateral septum
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Cordero, M.I., Just, N., Poirier, G.L., and Sandi, C.
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- 2016
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8. Building Treatments in Numerical Modeling of Dam Break Induced Flow in Urban Area.
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Sandi, C, Adityawan, M B, Nurendyastuti, A K, Farid, M, Harlan, D, Kuntoro, A A, and Widyaningtias
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- 2023
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9. Early life adversity perturbs mitostasis and drives inflammaging in the rat hippocampus
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Chaudhari, P., primary, Singla, A., additional, Kukkemane, K., additional, Suryavanshi, S., additional, Fanibunda, S., additional, Tiwari, P., additional, Dewan, V., additional, Pradhan, A., additional, Kolthur-Seetharam, U., additional, Vaidya, A., additional, Sandi, C., additional, and Vaidya, V., additional
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- 2023
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10. Blunted glucocorticoid responsiveness to stress causes behavioural and biological alterations that lead to PTSD vulnerability in rats
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Monari, S., primary, Guillot de Suduiraut, I., additional, Grosse, J., additional, Zanoletti, O., additional, Walker, E.S., additional, Mesquita, M., additional, Wood, T., additional, Cash, D., additional, Astori, S., additional, and Sandi, C., additional
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- 2023
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11. Incidence, risk factors and estimates of a woman's risk of developing secondary lower limb lymphedema and lymphedema-specific supportive care needs in women treated for endometrial cancer
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Beesley, Vanessa L., Rowlands, Ingrid J., Hayes, Sandi C., Janda, Monika, O'Rourke, Peter, Marquart, Louise, Quinn, Michael A., Spurdle, Amanda B., Obermair, Andreas, Brand, Alison, Oehler, Martin K., Leung, Yee, McQuire, Lesley, and Webb, Penelope M.
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- 2015
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12. Effects of Stress Throughout the Lifespan on the Brain and Behavior
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Nasca, C., primary, Davis, E., additional, Bigio, B., additional, Sandi, C., additional, and McEwen, B.S., additional
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- 2017
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13. Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders
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Ramírez S, Haddad-Tóvolli R, Radosevic M, Toledo M, Pané A, Alcolea D, Ribas V, Milà-Guasch M, Pozo M, Obri A, Eyre E, Gómez-Valadés AG, Chivite I, Van Eeckhout T, Zalachoras I, Altirriba J, Bauder C, Imbernón M, Garrabou G, Garcia-Ruiz C, Nogueiras R, Soto D, Gasull X, Sandi C, Brüning JC, Fortea J, Jiménez A, Fernández-Checa JC, Claret M.
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- 2022
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14. P.0633 Epigenome-wide DNA methylation in externalizing behaviours: a review and meta-analysis
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Meijer, M., primary, Zayats, T., additional, Starnawska, A., additional, Kranz, T., additional, Hoogman, M., additional, Buitelaar, J., additional, Reif, A., additional, Ribasés, M., additional, Haavik, J., additional, Franke, B., additional, Sandi, C., additional, and Klein, M., additional
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- 2021
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15. Long term effects of peripubertal stress on excitatory and inhibitory circuits in the prefrontal cortex of male and female mice
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Bueno-Fernandez C, Perez-Rando M, Alcaide J, Coviello S, Sandi C, Castillo-Gomez E, and Nacher J
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nervous system - Abstract
The impact of stressful events is especially important during early life, because certain cortical regions, especially the prefrontal cortex (PFC), are still developing. Consequently, aversive experiences that occur during the peripubertal period can cause long-term alterations in neural connectivity, physiology and related behaviors. Although sex influences the stress response and women are more likely to develop stress-related psychiatric disorders, knowledge about the effects of stress on females is still limited. In order to analyze the long-term effects of peripubertal stress (PPS) on the excitatory and inhibitory circuitry of the adult PFC, and whether these effects are sex-dependent, we applied an unpredictable chronic PPS protocol based on psychogenic stressors. Using two strains of transgenic mice with specific fluorescent cell reporters, we studied male and diestrus females to know how PPS affects the structure and connectivity of parvalbumin expressing (PV+) interneurons and pyramidal neurons. We also studied the expression of molecules related to excitatory and inhibitory neurotransmission, as well as alterations in the expression of plasticity-related molecules. The structure of pyramidal neurons was differentially affected by PPS in male and female mice: while the former had a decreased dendritic spine density, the latter displayed an increase in this parameter. PPS affected the density of puncta expressing excitatory and inhibitory synaptic markers exclusively in the female mPFC. Similarly, only in female mice we observed an increased complexity of the dendritic tree of PV+ neurons. Regarding the perisomatic innervation on pyramidal and PV+neurons by basket cells, we found a significant increase in the density of puncta in stressed animals, with interesting differences between the sexes and the type of basket cell analyzed. Finally, the PPS protocol also altered the total number of somata expressing the polysialylated form of the neural cell adhesion molecule (PSA-NCAM) when we analyzed both sexes together. These results highlight the strong programming effects of aversive experiences during early life for the establishment of cortical circuitry and the special impact of these stressful events on females.
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- 2021
16. Mitochondrial gene signature in the prefrontal cortex for differential susceptibility to chronic stress
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Weger, M., Alpern, D., Cherix, A., Ghosal, S., Grosse, J., Russeil, J., Gruetter, R., Kloet, E.R. de, Deplancke, B., and Sandi, C.
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Male ,Gene Expression Profiling ,lcsh:R ,lcsh:Medicine ,Prefrontal Cortex ,Resilience, Psychological ,Nucleus Accumbens ,Article ,Mitochondria ,Gonadotropin-Releasing Hormone ,Mice, Inbred C57BL ,Animals ,lcsh:Q ,Disease Susceptibility ,lcsh:Science ,Transcriptome ,Stress and resilience ,Stress, Psychological ,Neuroscience - Abstract
Mitochondrial dysfunction was highlighted as a crucial vulnerability factor for the development of depression. However, systemic studies assessing stress-induced changes in mitochondria-associated genes in brain regions relevant to depression symptomatology remain scarce. Here, we performed a genome-wide transcriptomic study to examine mitochondrial gene expression in the prefrontal cortex (PFC) and nucleus accumbens (NAc) of mice exposed to multimodal chronic restraint stress. We identified mitochondria-associated gene pathways as most prominently affected in the PFC and with lesser significance in the NAc. A more detailed mitochondrial gene expression analysis revealed that in particular mitochondrial DNA-encoded subunits of the oxidative phosphorylation complexes were altered in the PFC. The comparison of our data with a reanalyzed transcriptome data set of chronic variable stress mice and major depression disorder subjects showed that the changes in mitochondrial DNA-encoded genes are a feature generalizing to other chronic stress-protocols as well and might have translational relevance. Finally, we provide evidence for changes in mitochondrial outputs in the PFC following chronic stress that are indicative of mitochondrial dysfunction. Collectively, our work reinforces the idea that changes in mitochondrial gene expression are key players in the prefrontal adaptations observed in individuals with high behavioral susceptibility and resilience to chronic stress.
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- 2020
17. Programming effects of peripubertal stress on spatial learning
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Brain and Behavior Research Foundation, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Economía y Competitividad (España), Swiss National Science Foundation, National Centres of Competence in Research (Switzerland), Tzanoulinou, S., Gantelet, E., Sandi, C., Márquez, Cristina, Brain and Behavior Research Foundation, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Economía y Competitividad (España), Swiss National Science Foundation, National Centres of Competence in Research (Switzerland), Tzanoulinou, S., Gantelet, E., Sandi, C., and Márquez, Cristina
- Abstract
Exposure to adversity during early life can have profound influences on brain function and behavior later in life. The peripubertal period is emerging as an important time-window of susceptibility to stress, with substantial evidence documenting long-term consequences in the emotional and social domains. However, little is known about how stress during this period impacts subsequent cognitive functioning. Here, we assessed potential long-term effects of peripubertal stress on spatial learning and memory using the water maze task. In addition, we interrogated whether individual differences in stress-induced behavioral and endocrine changes are related to the degree of adaptation of the corticosterone response to repeated stressor exposure during the peripubertal period. We found that, when tested at adulthood, peripubertally stressed animals displayed a slower learning rate. Strikingly, the level of spatial orientation in the water maze completed on the last training day was predicted by the degree of adaptation of the recovery -and not the peak-of the corticosterone response to stressor exposure (i.e., plasma levels at 60 min post-stressor) across the peripubertal stress period. In addition, peripubertal stress led to changes in emotional and glucocorticoid reactivity to novelty exposure, as well as in the expression levels of the plasticity molecule PSA-NCAM in the hippocampus. Importantly, by assessing the same endpoints in another peripubertally stressed cohort tested during adolescence, we show that the observed effects at adulthood are the result of a delayed programming manifested at adulthood and not protracted effects of stress. Altogether, our results support the view that the degree of stress-induced adaptation of the hypothalamus-pituitary-adrenal axis responsiveness at the important transitional period of puberty relates to the long-term programming of cognition, behavior and endocrine reactivity.
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- 2020
18. Programming effects of peripubertal stress on spatial learning
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Tzanoulinou, S., primary, Gantelet, E., additional, Sandi, C., additional, and Márquez, C., additional
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- 2020
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19. LPA1 receptor and chronic stress: Effects on behaviour and the genes involved in the hippocampal excitatory/inhibitory balance
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Moreno-Fernández, R.D., primary, Rosell-Valle, C., additional, Bacq, A., additional, Zanoletti, O., additional, Cifuentes, M., additional, Pérez-Martín, M., additional, Gavito, A.L., additional, García-Fernández, M.I., additional, Estivill-Torrús, G., additional, Rodríguez de Fonseca, F., additional, Santín, L.J., additional, Sandi, C., additional, and Pedraza, C., additional
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- 2020
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20. Mitochondrial respiratory states and rate
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Gnaiger, E., Aasander Frostner, E., Abdul Karim, N., Abumrad, NA., Acuna-Castroviejo, D., Adiele, RC., Ahn, B., Ali, SS., Alton, L., Alves, MG., Amati, F., Amoedo, ND., Andreadou, I., Arago, M., Aral, C., Arandarcikaite, O., Armand, AS., Arnould, T., Avram, VF., Bailey, DM., Bajpeyi, S., Bajzikova, M., Bakker, BM., Barlow, J., Bastos Sant'Anna Silva, AC., Batterson, P., Battino, M., Bazil, J., Beard, DA., Bednarczyk, P., Bello, F., Ben-Shachar, D., Bergdahl, A., Berge, RK., Bergmeister, L., Bernardi, P., Berridge, MV., Bettinazzi, S., Bishop, D., Blier, PU., Blindheim, DF., Boardman, NT., Boetker, HE., Borchard, S., Boros, M., Borsheim, E., Borutaite, V., Botella, J., Bouillaud, F., Bouitbir, J., Boushel, RC., Bovard, J., Breton, S., Brown, DA., Brown, GC., Brown, RA., Brozinick, JT., Buettner, GR., Burtscher, J., Calabria, E., Calbet, JA., Calzia, E., Cannon, DT., Cano Sanchez, M., Canto, AC., Cardoso, LHD., Carvalho, E., Casado Pinna, M., Cassar, S., Cassina, AM., Castelo, MP., Castro, L., Cavalcanti-de-Albuquerque, JP., Cervinkova, Z., Chabi, B., Chakrabarti, L., Chakrabarti, S., Chaurasia, B., Chen, Q., Chicco, AJ., Chinopoulos, C., Chowdhury, SK., Cizmarova, B., Clementi, E., Coen, PM., Cohen, BH., Coker, RH., Collin, A., Crisostomo, L., Dahdah, N., Dalgaard, LT., Dambrova, M., Danhelovska, T., Darveau, CA., Das, AM., Dash, RK., Davidova, E., Davis, MS., De Goede, P., De Palma, C., Dembinska-Kiec, A., Detraux, D., Devaux, Y., Di Marcello, M., Dias, TR., Distefano, G., Doermann, N., Doerrier, C., Dong, L., Donnelly, C., Drahota, Z., Duarte, FV., Dubouchaud, H., Duchen, MR., Dumas, JF., Durham, WJ., Dymkowska, D., Dyrstad, SE., Dyson, A., Dzialowski, EM., Eaton, S., Ehinger, J., Elmer, E., Endlicher, R., Engin, AB., Escames, G., Ezrova, Z., Falk, MJ., Fell, DA., Ferdinandy, P., Ferko, M., Ferreira, JCB., Ferreira, R., Ferri, A., Fessel, JP., Filipovska, A., Fisar, Z., Fischer, C., Fischer, M., Fisher, G., Fisher, JJ., Ford, E., Fornaro, M., Galina, A., Galkin, A., Gallee, L., Galli, GL., Gama Perez, P., Gan, Z., Ganetzky, R., Garcia-Rivas, G., Garcia-Roves, PM., Garcia-Souza, LF., Garipi, E., Garlid, KD., Garrabou, G., Garten, A., Gastaldelli, A., Gayen, J., Genders, AJ., Genova, ML., Giovarelli, M., Goncalo Teixeira da Silva, R., Goncalves, DF., Gonzalez-Armenta, JL., Gonzalez-Freire, M., Gonzalo, H., Goodpaster, BH., Gorr, TA., Gourlay, CW., Granata, C., Grefte, S., Guarch, ME., Gueguen, N., Gumeni, S., Haas, CB., Haavik, J., Haendeler, J., Haider, M., Hamann, A., Han, J., Han, WH., Hancock, CR., Hand, SC., Handl, J., Hargreaves, IP., Harper, ME., Harrison, DK., Hassan, H., Hausenloy, DJ., Heales, SJR., Heiestad, C., Hellgren, KT., Hepple, RT., Hernansanz-Agustin, P., Hewakapuge, S., Hickey, AJ., Ho, DH., Hoehn, KL., Hoel, F., Holland, OJ., Holloway, GP., Hoppel, CL., Hoppel, F., Houstek, J., Huete-Ortega, M., Hyrossova, P., Iglesias-Gonzalez, J., Irving, BA., Isola, R., Iyer, S., Jackson, CB., Jadiya, P., Jana, PF., Jang, DH., Jang, YC., Janowska, J., Jansen, K., Jansen-Duerr, P., Jansone, B., Jarmuszkiewicz, W., Jaskiewicz, A., Jedlicka, J., Jespersen, NR., Jha, RK., Jurczak, MJ., Jurk, D., Kaambre, T., Kaczor, JJ., Kainulainen, H., Kampa, RP., Kandel, SM., Kane, DA., Kapferer, W., Kappler, L., Karabatsiakis, A., Karavaeva, I., Karkucinska-Wieckowska, A., Kaur, S., Keijer, J., Keller, MA., Keppner, G., Khamoui, AV., Kidere, D., Kilbaugh, T., Kim, HK., Kim, JKS., Klepinin, A., Klepinina, L., Klingenspor, M., Klocker, H., Komlodi, T., Koopman, WJH., Kopitar-Jerala, N., Kowaltowski, AJ., Kozlov, AV., Krajcova, A., Krako Jakovljevic, N., Kristal, BS., Krycer, JR., Kuang, J., Kucera, O., Kuka, J., Kwak, HB., Kwast, K., Laasmaa, M., Labieniec-Watala, M., Lagarrigue, S., Lai, N., Land, JM., Lane, N., Laner, V., Lanza, IR., Laranjinha, J., Larsen, TS., Lavery, GG., Lazou, A., Lee, HK., Leeuwenburgh, C., Lehti, M., Lemieux, H., Lenaz, G., Lerfall, J., Li, PA., Li Puma, L., Liepins, E., Liu, J., Lopez, LC., Lucchinetti, E., Ma, T., Macedo, MP., Maciej, S., MacMillan-Crow, LA., Majtnerova, P., Makarova, E., Makrecka-Kuka, M., Malik, AN., Markova, M., Martin, DS., Martins, AD., Martins, JD., Maseko, TE., Maull, F., Mazat, JP., McKenna, HT., McKenzie, M., Menze, MA., Merz, T., Meszaros, AT., Methner, A., Michalak, S., Moellering, DR., Moisoi, N., Molina, AJA., Montaigne, D., Moore, AL., Moreau, K., Moreira, BP., Moreno-Sanchez, R., Mracek, T., Muccini, AM., Munro, D., Muntane, J., Muntean, DM., Murray, AJ., Musiol, E., Nabben, M., Nair, KS., Nehlin, JO., Nemec, M., Neufer, PD., Neuzil, J., Neviere, R., Newsom, SA., Nozickova, K., O'Brien, KA., O'Gorman, D., Olgar, Y., Oliveira, B., Oliveira, MF., Oliveira, MT., Oliveira, PF., Oliveira, PJ., Orynbayeva, Z., Osiewacz, HD., Pak, YK., Pallotta, ML., Palmeira, CM., Parajuli, N., Passos, JF., Passrugger, M., Patel, HH., Pavlova, N., Pecina, P., Pedersen, TM., Pereira da Silva Grilo da Silva, F., Pereira, SP., Perez Valencia, JA., Perks, KL., Pesta, D., Petit, PX., Pettersen, IKN., Pichaud, N., Pichler, I., Piel, S., Pietka, TA., Pino, MF., Pirkmajer, S., Plangger, M., Porter, C., Porter, RK., Procaccio, V., Prochownik, EV., Prola, A., Pulinilkunnil, T., Puskarich, MA., Puurand, M., Radenkovic, F., Ramzan, R., Rattan, SIS., Reboredo, P., Renner-Sattler, K., Rial, E., Robinson, MM., Roden, M., Rodriguez, E., Rodriguez-Enriquez, S., Roesland, GV., Rohlena, J., Rolo, AP., Ropelle, ER., Rossignol, R., Rossiter, HB., Rubelj, I., Rybacka-Mossakowska, J., Saada, A., Safaei, Z., Saharnaz, S., Salin, K., Salvadego, D., Sandi, C., Saner, N., Sanz, A., Sazanov, LA., Scatena, R., Schartner, M., Scheibye-Knudsen, M., Schilling, JM., Schlattner, U., Schoenfeld, P., Schots, PC., Schulz, R., Schwarzer, C., Scott, GR., Selman, C., Shabalina, IG., Sharma, P., Sharma, V., Shevchuk, I., Shirazi, R., Shiroma, JG., Siewiera, K., Silber, AM., Silva, AM., Sims, CA., Singer, D., Singh, BK., Skolik, R., Smenes, BT., Smith, J., Soares, FAA., Sobotka, O., Sokolova, I., Sonkar, VK., Sowton, AP., Sparagna, GC., Sparks, LM., Spinazzi, M., Stankova, P., Starr, J., Stary, C., Stelfa, G., Stepto, NK., Stiban, J., Stier, A., Stocker, R., Storder, J., Sumbalova, Z., Suomalainen, A., Suravajhala, P., Svalbe, B., Swerdlow, RH., Swiniuch, D., Szabo, I., Szewczyk, A., Szibor, M., Tanaka, M., Tandler, B., Tarnopolsky, MA., Tausan, D., Tavernarakis, N., Tepp, K., Thakkar, H., Thapa, M., Thyfault, JP., Tomar, D., Ton, R., Torp, MK., Towheed, A., Tretter, L., Trewin, AJ., Trifunovic, A., Trivigno, C., Tronstad, KJ., Trougakos, IP., Truu, L., Tuncay, E., Turan, B., Tyrrell, DJ., Urban, T., Valentine, JM., Van Bergen, NJ., Van Hove, J., Varricchio, F., Vella, J., Vendelin, M., Vercesi, AE., Victor, VM., Vieira Ligo Teixeira, C., Vidimce, J., Viel, C., Vieyra, A., Vilks, K., Villena, JA., Vincent, V., Vinogradov, AD., Viscomi, C., Vitorino, RMP., Vogt, S., Volani, C., Volska, K., Votion, DM., Vujacic-Mirski, K., Wagner, BA., Ward, ML., Warnsmann, V., Wasserman, DH., Watala, C., Wei, YH., Whitfield, J., Wickert, A., Wieckowski, MR., Wiesner, RJ., Williams, CM., Winwood-Smith, H., Wohlgemuth, SE., Wohlwend, M., Wolff, JN., Wrutniak-Cabello, C., Wuest, RCI., Yokota, T., Zablocki, K., Zanon, A., Zanou, N., Zaugg, K., Zaugg, M., Zdrazilova, L., Zhang, Y., Zhang, YZ., Zikova, A., Zischka, H., Zorzano, A., and Zvejniece, L.
- Subjects
Mitochondrial respiratory control, coupling control, mitochondrial preparations, protonmotive force, uncoupling, oxidative phosphorylation, OXPHOS, efficiency, electron transfer, ET ,proton leak, LEAK, residual oxygen consumption, ROX, State 2, State 3, State 4, normalization, flow, flux, O2 - Abstract
As the knowledge base and importance of mitochondrial physiology to human health expands, the necessity for harmonizing the terminologyconcerning mitochondrial respiratory states and rates has become increasingly apparent. Thechemiosmotic theoryestablishes the mechanism of energy transformationandcoupling in oxidative phosphorylation. Theunifying concept of the protonmotive force providestheframeworkfordeveloping a consistent theoretical foundation ofmitochondrial physiology and bioenergetics.We followguidelines of the International Union of Pure and Applied Chemistry(IUPAC)onterminology inphysical chemistry, extended by considerationsofopen systems and thermodynamicsof irreversible processes.Theconcept-driven constructive terminology incorporates the meaning of each quantity and alignsconcepts and symbols withthe nomenclature of classicalbioenergetics. We endeavour to provide a balanced view ofmitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes.Uniform standards for evaluation of respiratory states and rates will ultimatelycontribute to reproducibility between laboratories and thussupport the development of databases of mitochondrial respiratory function in species, tissues, and cells.Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery.
- Published
- 2019
21. Neuropharmacology of the mesolimbic system and associated circuits on social hierarchies
- Author
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Ghosal, S., Sandi, C., van der Kooij, M.A., Ghosal, S., Sandi, C., and van der Kooij, M.A.
- Abstract
Most socially living species are organized hierarchically, primarily based on individual differences in social dominance. Dominant individuals typically gain privileged access to important resources, such as food, mating partners and territories, whereas submissive conspecifics are often devoid of such benefits. The benefits associated with a high social status provide a strong incentive to become dominant. Importantly, motivational- and reward-related processes are regulated, to a large extent, by the mesolimbic system. Consequently, several studies point to a key role for the mesolimbic system in social hierarchy formation. This review summarizes the growing body of literature that implicates the mesolimbic system, and associated neural circuits, on social hierarchies. In particular, we discuss the neurochemical and pharmacological studies that have highlighted the contributions of the mesolimbic system and associated circuits including dopamine signaling through the D1 or D2 receptors, GABAergic neurotransmission, the androgen receptor system, and mitochondria and bioenergetics. Given that low social status has been linked to the emergence of anxiety- and depressive-like disorders, a greater understanding of the neurochemistry underlying social dominance could be of tremendous benefit for the development of pharmacological treatments to dysfunctions in social behaviors.
- Published
- 2019
- Full Text
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22. Neuropharmacology of the mesolimbic system and associated circuits on social hierarchies
- Author
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Ghosal, S., primary, Sandi, C., additional, and van der Kooij, M.A., additional
- Published
- 2019
- Full Text
- View/download PDF
23. S.13.01 Brain energy metabolism regulates vulnerability to stress
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Sandi, C., primary
- Published
- 2019
- Full Text
- View/download PDF
24. Diazepam actions in the VTA enhance social dominance and mitochondrial function in the nucleus accumbens by activation of dopamine D1 receptors
- Author
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van der Kooij, M A, primary, Hollis, F, additional, Lozano, L, additional, Zalachoras, I, additional, Abad, S, additional, Zanoletti, O, additional, Grosse, J, additional, Guillot de Suduiraut, I, additional, Canto, C, additional, and Sandi, C, additional
- Published
- 2017
- Full Text
- View/download PDF
25. Identification of telomere dysfunction in Friedreich ataxia
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Anjomani-Virmouni, S, Al-Mahdawi, S, Sandi, C, Yasaei, H, Slijepcevic, P, and Pook, M
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telomere dysfunction ,Friedreich ataxia - Abstract
In Friedreich ataxia (FRDA), GAA repeat expansion within the first intron of the frataxin (FXN) gene leads to downregulation of FXN, resulting in oxidative stress, mitochondrial iron accumulation and neuronal atrophy. We hypothesised that telomere length might be shortened as a result of oxidative damage in FRDA. To investigate telomere function in FRDA, we initially assessed the telomere length in human and mouse FRDA fibroblasts and we found that both cell types had chromosomes with relatively longer telomeric repeats compared to controls. In contrast, we noted a significant telomere shortening in FRDA leukocyte cells compared to control cells. Consequently, we screened the FRDA fibroblasts for expression of telomerase activity and we identified that the telomerase activity was not present in these cells. We then assessed the co-localisation of PML bodies with telomeres and frequencies of telomere sister chromatid exchange (T-SCE) in these cells. Our results showed significantly higher co-localised PML foci with telomeric DNA and substantially higher T-SCE levels in the FRDA cell lines relative to the controls suggesting activation of an alternative lengthening of telomeres (ALT)-like mechanism. Analysis of growth curve and population doubling times of these cells revealed that the FRDA fibroblast cultures underwent growth arrest with higher cumulative population doubling compared to the controls. However, further analysis of telomere length at different passage numbers revealed that the telomere length in the FRDA cells shortened faster than the controls. Finally, we detected a significantly higher frequency of γ-H2AX foci and telomere dysfunction-induced foci (TIF) in the FRDA cells compared to the controls, suggesting induced telomere dysfunction in these cells. In conclusion, our results demonstrate a telomere dysfunction phenotype and accelerated telomere shortening in FRDA cells. In addition, the results suggest that intertelomeric recombination was initiated in the FRDA cells but was not capable of preventing accelerated telomere shortening.
- Published
- 2015
26. Genotype and phenotype characterisation of enhanced Friedreich’s ataxia GAA repeat expansion mouse models
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Anjomani Virmouni, S, Sandi, C, Ezzatizadeh, V, Sandi, M, Al-Mahdawi, S, Pook, M, and Anjomani-Virmouni, S
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Friedreich ataxia GAA ,Expansion mouse models - Published
- 2015
27. A Case of Iliopsoas Bursitis With Compressive Femoral Nerve Palsy Treated With Iliopsoas Tendon Release
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Jordan Conroy, MD, Sandi Caus, BS, and Nathaniel J. Nelms, MD
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Iliopsoas bursitis ,Iliopsoas tendonitis ,Femoral nerve palsy ,Total hip arthroplasty ,Orthopedic surgery ,RD701-811 - Abstract
Iliopsoas bursitis is a well-established cause of groin pain after total hip arthroplasty (THA), and it can become dramatically more complex when associated with neurovascular compression. Iliopsoas bursitis may be caused by a variety of pathologies in the setting of a THA but most frequently due to a prominent acetabular component or implant wear. Here we report a rare case of a female patient presenting with iliopsoas tendonitis, an accompanying femoral nerve palsy, and debilitating pain beginning 12 years after a previously successful primary THA without apparent implant wear. Ultimately, our patient was treated successfully with iliopsoas tendon release for anterior prominence of the acetabular component.
- Published
- 2022
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28. Effects of paternal and peripubertal stress on aggression, anxiety, and metabolic alterations in the lateral septum
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Cordero, MI, Just, N, Poirier, GL, Sandi, C, Cordero, MI, Just, N, Poirier, GL, and Sandi, C
- Abstract
Early-life stress and biological predispositions are linked to mood and personality disorders related to aggressive behavior. We previously showed that exposure to peripubertal stress leads to increased anxiety-like behaviors and aggression against males and females, as well as increased aggression against females in their male offspring. Here, we investigated whether paternal (pS) and individual (iS) exposure to peripubertal stress may exert additive effects on the long-term programming of anxiety-like and aggressive behaviors in rats. Given the key role of the lateral septum (LS) in the regulation of anxiety and aggressive behaviors and the hypothesized alterations in balance between neural excitation and inhibition in aggression-related disorders, markers for these processes were examined in the LS. Peripubertal stress was applied both in naïve male rats and in the offspring of peripubertally stressed males, and anxiety-like and aggressive behaviors were assessed at adulthood. Proton magnetic resonance spectroscopy at 6-months, and post-mortem analysis of glutamic acid decarboxylase 67 (GAD67) at 12-months were conducted in LS. We confirmed that aggressive behavior was increased by pS and iS, while only iS increased anxiety-like behavior. Individual stress led to reduced GABA, confirmed by reduced GAD67 immunolabelling, and increased glutamate, N-acetyl-aspartate, phosphocholine and creatine; while pS specifically led to reduced phosphocreatine. pS and iS do not interact and exert a differential impact on the analyzed aspects of brain function and anxiety-like behaviors. These data support the view that early-life stress can affect the behavioral and neurodevelopmental trajectories of individuals and their offspring, which may involve different neurobiological mechanisms.
- Published
- 2016
29. Acute stress alters individual risk taking in a time-dependent manner and leads to anti-social risk
- Author
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Bendahan, S., primary, Goette, L., additional, Thoresen, J., additional, Loued-Khenissi, L., additional, Hollis, F., additional, and Sandi, C., additional
- Published
- 2016
- Full Text
- View/download PDF
30. 'Mitochondrial energy imbalance and lipid peroxidation cause cell death in Friedreich’s ataxia'
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Abeti, R, primary, Parkinson, M H, additional, Hargreaves, I P, additional, Angelova, P R, additional, Sandi, C, additional, Pook, M A, additional, Giunti, P, additional, and Abramov, A Y, additional
- Published
- 2016
- Full Text
- View/download PDF
31. Effects of paternal and peripubertal stress on aggression, anxiety, and metabolic alterations in the lateral septum
- Author
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Cordero, MI, Just, N, Poirier, GL, Sandi, C, Cordero, MI, Just, N, Poirier, GL, and Sandi, C
- Abstract
Early–life stress and biological predispositions are linked to mood and personality disorders related to aggressive behavior. We previously showed that exposure to peripubertal stress leads to increased anxiety-like behaviors and aggression against males and females, as well as increased aggression against females in their male offspring. Here, we investigated whether paternal (pS) and individual (iS) exposure to peripubertal stress may exert additive effects on the long-term programming of anxiety-like and aggressive behaviors in rats. Given the key role of the lateral septum (LS) in the regulation of anxiety and aggressive behaviors and the hypothesized alterations in balance between neural excitation and inhibition in aggression-related disorders, markers for these processes were examined in the LS. Peripubertal stress was applied both in naïve male rats and in the offspring of peripubertally stressed males, and anxiety-like and aggressive behaviors were assessed at adulthood. Proton magnetic resonance spectroscopy at 6-months, and post-mortem analysis of glutamic acid decarboxylase 67 (GAD67) at 12-months were conducted in LS. We confirmed that aggressive behavior was increased by pS and iS, while only iS increased anxiety-like behavior. Individual stress led to reduced GABA, confirmed by reduced GAD67 immunolabelling, and increased Glutamate, N-acetyl-aspartate, Phosphocholine and Creatine; while pS specifically led to reduced Phosphocreatine. pS and iS do not interact and exert a differential impact on the analyzed aspects of brain function and anxiety-like behaviors. These data support the view that early– life stress can affect the behavioral and neurodevelopmental trajectories of individuals and their offspring, which may involve different neurobiological mechanisms.
- Published
- 2015
32. Incidence, Risk Factors, and Estimates of a Woman’s Risk for Developing Secondary Lower Limb Lymphedema and Lymphedema-Specific Supportive Care Needs in Women Treated for Endometrial Cancer
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Vanessa L. Beesley, Ingrid J. Rowlands, Sandi C. Hayes, Monika Janda, Peter O’Rourke, Louise Marquart, Michael A. Quinn, Amanda B. Spurdle, Andreas Obermair, Alison Brand, Martin K. Oehler, Yee Leung, Lesley McQuire, and Penelope M. Webb
- Subjects
Obstetrics and Gynecology ,General Medicine - Published
- 2015
33. The effects of stress during early postnatal periods on behavior and hippocampal neuroplasticity markers in adult male mice
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van der Kooij, M.A., primary, Grosse, J., additional, Zanoletti, O., additional, Papilloud, A., additional, and Sandi, C., additional
- Published
- 2015
- Full Text
- View/download PDF
34. Building Community in Online Professional Practice Doctoral Programs
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Cece Lynn Lively, Brooke Blevins, Sandra Talbert, and Sandi Cooper
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community ,online education ,edd ,cohort ,student support ,Special aspects of education ,LC8-6691 - Abstract
Despite high attrition rates and abundant criticisms, online graduate programs continue to grow. This paper describes the efforts of one online doctoral program that focused on developing programmatic support structures to increase community. Utilizing a qualitative, case study research design, including surveys and semi-structured interviews, this study examined two research questions: 1) In what ways did students experience a sense of community? 2) What elements of an online professional doctoral program did students find most influential in developing a learning community? Findings indicate that students experience community through peer collaboration, program support, and shared learning and networking. A sense of community was developed through the cohort model, strong student support services, synchronous live sessions, and relationships formed with faculty. As a result, a community of practice was formed among program participants. Findings from this study have the potential to aid other online graduate programs as they design and implement structures to foster student success and retention.
- Published
- 2021
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- View/download PDF
35. Incidence, Risk Factors, and Estimates of a Woman’s Risk for Developing Secondary Lower Limb Lymphedema and Lymphedema-Specific Supportive Care Needs in Women Treated for Endometrial Cancer
- Author
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Beesley, Vanessa L., primary, Rowlands, Ingrid J., additional, Hayes, Sandi C., additional, Janda, Monika, additional, O’Rourke, Peter, additional, Marquart, Louise, additional, Quinn, Michael A., additional, Spurdle, Amanda B., additional, Obermair, Andreas, additional, Brand, Alison, additional, Oehler, Martin K., additional, Leung, Yee, additional, McQuire, Lesley, additional, and Webb, Penelope M., additional
- Published
- 2015
- Full Text
- View/download PDF
36. Acute stress alters individual risk taking in a time-dependent manner and leads to anti-social risk.
- Author
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Bendahan, S., Goette, L., Thoresen, J., Loued‐Khenissi, L., Hollis, F., Sandi, C., and Foxe, John
- Subjects
ACUTE stress disorder ,PHYSIOLOGICAL stress ,DELINQUENT behavior ,HYPOTHALAMIC-pituitary-adrenal axis ,SYMPATHETIC nervous system - Abstract
Decision-making processes can be modulated by stress, and the time elapsed from stress induction seems to be a crucial factor in determining the direction of the effects. Although current approaches consider the first post-stress hour a uniform period, the dynamic pattern of activation of the physiological stress systems (i.e., the sympathetic nervous system and hypothalamic-pituitary-adrenal axis) suggests that its neurobehavioural impact might be heterogeneous. Here, we evaluate economic risk preferences on the gain domain (i.e., risk aversion) at three time points following exposure to psychosocial stress (immediately after, and 20 and 45 min from onset). Using lottery games, we examine decisions at both the individual and social levels. We find that risk aversion shows a time-dependent change across the first post-stress hour, evolving from less risk aversion shortly after stress to more risk averse behaviour at the last testing time. When risk implied an antisocial outcome to a third party, stressed individuals showed less regard for this person in their decisions. Participants' cortisol levels explained their behaviour in the risk, but not the antisocial, game. Our findings reveal differential stress effects in self- and other-regarding decision-making and highlight the multidimensional nature of the immediate aftermath of stress for cognition. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
37. Diazepam actions in the VTA enhance social dominance and mitochondrial function in the nucleus accumbens by activation of dopamine D1 receptors
- Author
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van der Kooij, M A, Hollis, F, Lozano, L, Zalachoras, I, Abad, S, Zanoletti, O, Grosse, J, Guillot de Suduiraut, I, Canto, C, and Sandi, C
- Abstract
Benzodiazepines can ameliorate social disturbances and increase social competition, particularly in high-anxious individuals. However, the neural circuits and mechanisms underlying benzodiazepines’ effects in social competition are not understood. Converging evidence points to the mesolimbic system as a potential site of action for at least some benzodiazepine-mediated effects. Furthermore, mitochondrial function in the nucleus accumbens (NAc) has been causally implicated in the link between anxiety and social competitiveness. Here, we show that diazepam facilitates social dominance, ameliorating both the competitive disadvantage and low NAc mitochondrial function displayed by high-anxious rats, and identify the ventral tegmental area (VTA) as a key site of action for direct diazepam effects. We also show that intra-VTA diazepam infusion increases accumbal dopamine and DOPAC, as well as activity of dopamine D1- but not D2-containing cells. In addition, intra-NAc infusion of a D1-, but not D2, receptor agonist facilitates social dominance and mitochondrial respiration. Conversely, intra-VTA diazepam actions on social dominance and NAc mitochondrial respiration are blocked by pharmacological NAc micro-infusion of a mitochondrial complex I inhibitor or an antagonist of D1 receptors. Our data support the view that diazepam disinhibits VTA dopaminergic neurons, leading to the release of dopamine into the NAc where activation of D1-signaling transiently facilitates mitochondrial function, that is, increased respiration and enhanced ATP levels, which ultimately enhances social competitive behavior. Therefore, our findings critically involve the mesolimbic system in the facilitating effects of diazepam on social competition and highlight mitochondrial function as a potential therapeutic target for anxiety-related social dysfunctions.
- Published
- 2018
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38. Reframing the Problem of Practice: Transitions in Baylor University’s Ed.D. in Learning and Organizational Change Program
- Author
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Brooke E. Blevins, Sandi Cooper, Lacy K. Crocker Papadakis, Julia Earl, Leanne Howell, Cece Lively, Jessica Meehan, Elizabeth Anne Murray, Sarah Pratt, Laila Sanguras, Sandra Talbert, Tony L. Talbert, and Nicholas R. Werse
- Subjects
Dissertation in Practice ,Problem of Practice ,Education Doctorate ,Organizational Change ,Professional Doctorate ,Special aspects of education ,LC8-6691 - Abstract
This article reports on the program changes that emerged from the Baylor University Ed.D. in Learning and Organizational Change program development team as we engaged as a community of practice in the organizational change process to reframe our conceptualization of the Problem of Practice dissertation. This process led to logical implications for the program course offerings and student support systems. The following article, therefore, traces these changes as they emanate out from the Problem of Practice dissertation reconfiguration, into the course sequence, and finally the student support systems. This article concludes by offering the perspective gained about this work as we engaged in the same organizational change process through which we guide our students.
- Published
- 2022
- Full Text
- View/download PDF
39. Corrigendum: Parents' Perceptions About Future Digital Parental Support—A Phenomenographic Interview Study
- Author
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Caroline Bäckström, Sandi Chamoun, Shazima Tejani, and Viveca Larsson
- Subjects
digital health literacy ,professional support ,pregnancy ,childbirth ,labor ,parenting ,Medicine ,Public aspects of medicine ,RA1-1270 ,Electronic computers. Computer science ,QA75.5-76.95 - Published
- 2021
- Full Text
- View/download PDF
40. Parents' Perceptions About Future Digital Parental Support—A Phenomenographic Interview Study
- Author
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Caroline Bäckström, Sandi Chamoun, Shazima Tejani, and Viveca Larsson
- Subjects
digital health literacy ,professional support ,pregnancy ,childbirth ,labor ,parenting ,Medicine ,Public aspects of medicine ,RA1-1270 ,Electronic computers. Computer science ,QA75.5-76.95 - Abstract
Background: Parents use digital sources (such as the internet or online forums and applications) during pregnancy and after childbirth to receive informative support. Research shows that there is further need for innovation development in digital parental support despite informative support available in digital form.Purpose: To explore parents' perceptions of future digital parental support concerning pregnancy and the first 18 months of parenthood.Method: A phenomenographic interview study with an inductive approach including 15 semi-structured interviews was conducted.Results: The analysis process resulted in three descriptive categories: Opportunities for virtual and in-person meetings, Individualized digital parental support, and Professional knowledge and trustworthiness concerning future digital parental support.Conclusion: The results broaden the knowledge about how future digital parental support can be designed to facilitate the functional, interactive, and critical digital health literacy of new and would-be parents. To succeed, healthcare organizations should allow healthcare professionals to assume an active role in developing digital parental support, both as health educators (i.e., providing parents with knowledge) and facilitators (i.e., facilitating parents' use of digital parental support). However, parents perceived that future digital parental support should complement standard care instead of replacing in-person meetings with healthcare professionals.
- Published
- 2021
- Full Text
- View/download PDF
41. SISTEM PENDUKUNG KEPUTUSAN SELEKSI PENERIMA SUBSIDI BERAS SEJAHTERA PADA KELURAHAN CIBEUNYING DENGAN METODE ANALITYCAL HIERARCHY PROCESS (AHP)
- Author
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Ade Mubarok and Sandi Cahyadi
- Subjects
sistem penunjang keputusan, proses seleksi penerima subsidi, rastra, analitycal hierarchy process (ahp) ,Technology - Abstract
Abstrak - Proses seleksi adalah serangkaian langkah kegiatan yang digunakan untuk memutuskan apakah calon penerima subsidi diterima atau tidak. Tujuan dari sistem penunjang keputusan seleksi penerima subsidi beras sejahtera (RASTRA) ini yaitu untuk membantu bagian Kasi Pemberdayaan Masyarakat dalam melakukan proses seleksi yang cepat dan tepat yang sesuai dengan beberapa kriteria yaitu, jumlah penghasilan, jenis pekerjaan, jumlah tanggungan, umur dan kepemilikan rumah. Oleh sebab itu, peneliti menggunakan metode Analitycal Hierarchy Process (AHP) untuk menyelesaikan permasalahan yang ada. Metode ini dipilih karena suatu bentuk model pendukung keputusan dimana peralatan utamanya adalah sebuah hierarki fungsional dengan input utamanya persepsi manusia, yakni dalam hal ini adalah orang yang ahli dalam permasalahan proses seleksi calon seleksi penerima subsidi beras sejahtera Hasil dari penelitian ini adalah berupa aplikasi sistem pendukung keputusan seleksi yang dibangun sebagai alat bantu untuk penentuan berhak tidaknya warga untuk mendapatkan subsidi. Abstract - The selection process is a series of activity steps used to decide whether prospective recipients of subsidies are accepted or not. The purpose of the decision support system for selection of recipients of prosperous rice subsidies (RASTRA) is to assist the Community Empowerment Section in conducting a quick and precise selection process that is in accordance with several criteria, namely, the amount of income, type of work, number of dependents, age and home ownership. Therefore, researchers use the Analyticalcal Hierarchy Process (AHP) method to solve existing problems. This method was chosen because of a form of decision support model in which the main equipment is a functional hierarchy with the main input of human perception, ie in this case an expert in the problem of the selection process for the selection of prospective recipients of prosperous rice subsidies. The results of this study are in the form of the application of a selection decision support system that was built as a tool for determining whether citizens are entitled to subsidies.
- Published
- 2019
- Full Text
- View/download PDF
42. Diel population and functional synchrony of microbial communities on coral reefs
- Author
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Linda Wegley Kelly, Craig E. Nelson, Andreas F. Haas, Douglas S. Naliboff, Sandi Calhoun, Craig A. Carlson, Robert A. Edwards, Michael D. Fox, Mark Hatay, Maggie D. Johnson, Emily L. A. Kelly, Yan Wei Lim, Saichetana Macherla, Zachary A. Quinlan, Genivaldo Gueiros Z. Silva, Mark J. A. Vermeij, Brian Zgliczynski, Stuart A. Sandin, Jennifer E. Smith, and Forest Rohwer
- Subjects
Science - Abstract
Microbes structure biogeochemical cycles and food webs in the marine environment. Here, the authors sample coral reef-associated microbes across a 24-hour period, showing clear day–night patterns of microbial populations and thus calling for more studies to consider temporal variation in microbiomes at this scale.
- Published
- 2019
- Full Text
- View/download PDF
43. CURRENT COGNITION OF ROCK TENSILE STRENGTH TESTING BY BRAZILIAN TEST
- Author
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Zlatko Briševac, Trpimir Kujundžić, and Sandi Čajić
- Subjects
Tensile strength ,indirect tensile strength ,Brazilian test ,rock mechanics ,Mining engineering. Metallurgy ,TN1-997 ,Geology ,QE1-996.5 - Abstract
Tensile strength in rock mechanics is a characteristic more frequently determined in the indirect rather than direct way. This paper presents a historical review of the development of the indirect method called the Brazilian test, comprising the period from 1943 to the present day. It stresses some aspects which are essential for interpreting the results of the Brazilian test due to the different degrees of stress during the testing and the direct method of determining tensile strength. The estimate of the direct tensile strength and the influence of sample saturation on the results of indirect tensile strength testing have been specifically elaborated.
- Published
- 2015
- Full Text
- View/download PDF
44. The clinical effectiveness of individual behaviour change interventions to reduce risky sexual behaviour after a negative human immunodeficiency virus test in men who have sex with men: systematic and realist reviews and intervention development
- Author
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Paul Flowers, Olivia Wu, Karen Lorimer, Bipasha Ahmed, Hannah Hesselgreaves, Jennifer MacDonald, Sandi Cayless, Sharon Hutchinson, Lawrie Elliott, Ann Sullivan, Dan Clutterbuck, Michael Rayment, and Lisa McDaid
- Subjects
men who have sex with men ,human immunodeficiency virus ,behaviour change ,intervention ,systematic review ,realist review ,Medical technology ,R855-855.5 - Abstract
Background: Men who have sex with men (MSM) experience significant inequalities in health and well-being. They are the group in the UK at the highest risk of acquiring a human immunodeficiency virus (HIV) infection. Guidance relating to both HIV infection prevention, in general, and individual-level behaviour change interventions, in particular, is very limited. Objectives: To conduct an evidence synthesis of the clinical effectiveness of behaviour change interventions to reduce risky sexual behaviour among MSM after a negative HIV infection test. To identify effective components within interventions in reducing HIV risk-related behaviours and develop a candidate intervention. To host expert events addressing the implementation and optimisation of a candidate intervention. Data sources: All major electronic databases (British Education Index, BioMed Central, Cumulative Index to Nursing and Allied Health Literature, EMBASE, Educational Resource Index and Abstracts, Health and Medical Complete, MEDLINE, PsycARTICLES, PsycINFO, PubMed and Social Science Citation Index) were searched between January 2000 and December 2014. Review methods: A systematic review of the clinical effectiveness of individual behaviour change interventions was conducted. Interventions were examined using the behaviour change technique (BCT) taxonomy, theory coding assessment, mode of delivery and proximity to HIV infection testing. Data were summarised in narrative review and, when appropriate, meta-analysis was carried out. Supplemental analyses for the development of the candidate intervention focused on post hoc realist review method, the assessment of the sequential delivery and content of intervention components, and the social and historical context of primary studies. Expert panels reviewed the candidate intervention for issues of implementation and optimisation. Results: Overall, trials included in this review (n = 10) demonstrated that individual-level behaviour change interventions are effective in reducing key HIV infection risk-related behaviours. However, there was considerable clinical and methodological heterogeneity among the trials. Exploratory meta-analysis showed a statistically significant reduction in behaviours associated with high risk of HIV transmission (risk ratio 0.75, 95% confidence interval 0.62 to 0.91). Additional stratified analyses suggested that effectiveness may be enhanced through face-to-face contact immediately after testing, and that theory-based content and BCTs drawn from ‘goals and planning’ and ‘identity’ groups are important. All evidence collated in the review was synthesised to develop a candidate intervention. Experts highlighted overall acceptability of the intervention and outlined key ways that the candidate intervention could be optimised to enhance UK implementation. Limitations: There was a limited number of primary studies. All were from outside the UK and were subject to considerable clinical, methodological and statistical heterogeneity. The findings of the meta-analysis must therefore be treated with caution. The lack of detailed intervention manuals limited the assessment of intervention content, delivery and fidelity. Conclusions: Evidence regarding the effectiveness of behaviour change interventions suggests that they are effective in changing behaviour associated with HIV transmission. Exploratory stratified meta-analyses suggested that interventions should be delivered face to face and immediately after testing. There are uncertainties around the generalisability of these findings to the UK setting. However, UK experts found the intervention acceptable and provided ways of optimising the candidate intervention. Future work: There is a need for well-designed, UK-based trials of individual behaviour change interventions that clearly articulate intervention content and demonstrate intervention fidelity. Study registration: The study is registered as PROSPERO CRD42014009500. Funding: The National Institute for Health Research Health Technology Assessment programme.
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- 2017
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45. Can we measure beauty? Computational evaluation of coral reef aesthetics
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Andreas F. Haas, Marine Guibert, Anja Foerschner, Tim Co, Sandi Calhoun, Emma George, Mark Hatay, Elizabeth Dinsdale, Stuart A. Sandin, Jennifer E. Smith, Mark J.A. Vermeij, Ben Felts, Phillip Dustan, Peter Salamon, and Forest Rohwer
- Subjects
Image analysis ,Coral reef ,Aesthetics ,Machine learning ,Reef degradation ,Medicine ,Biology (General) ,QH301-705.5 - Abstract
The natural beauty of coral reefs attracts millions of tourists worldwide resulting in substantial revenues for the adjoining economies. Although their visual appearance is a pivotal factor attracting humans to coral reefs current monitoring protocols exclusively target biogeochemical parameters, neglecting changes in their aesthetic appearance. Here we introduce a standardized computational approach to assess coral reef environments based on 109 visual features designed to evaluate the aesthetic appearance of art. The main feature groups include color intensity and diversity of the image, relative size, color, and distribution of discernable objects within the image, and texture. Specific coral reef aesthetic values combining all 109 features were calibrated against an established biogeochemical assessment (NCEAS) using machine learning algorithms. These values were generated for ∼2,100 random photographic images collected from 9 coral reef locations exposed to varying levels of anthropogenic influence across 2 ocean systems. Aesthetic values proved accurate predictors of the NCEAS scores (root mean square error < 5 for N ≥ 3) and significantly correlated to microbial abundance at each site. This shows that mathematical approaches designed to assess the aesthetic appearance of photographic images can be used as an inexpensive monitoring tool for coral reef ecosystems. It further suggests that human perception of aesthetics is not purely subjective but influenced by inherent reactions towards measurable visual cues. By quantifying aesthetic features of coral reef systems this method provides a cost efficient monitoring tool that targets one of the most important socioeconomic values of coral reefs directly tied to revenue for its local population.
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- 2015
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46. Epigenetics in externalizing behaviours: Linking the environment and genetics as a key to understanding externalizing behaviours across species
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Meijer, M., Franke, B., Sandi, C., Klein, M., and Radboud University Nijmegen
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Neurodevelopmental disorders [Radboudumc 7] ,Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7] ,Donders Series ,Donders Center for Medical Neuroscience - Abstract
Contains fulltext : 289574.pdf (Publisher’s version ) (Open Access) Radboud University, 07 maart 2023 Promotores : Franke, B., Sandi, C. Co-promotor : Klein, M. 355 p.
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- 2023
47. Novel non-transgenic rat tauopathy model induced by injection of tau oligomers into the entorhinal cortex
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Langer Horvat, Lea, Španić, Ena, Babić Leko, Mirjana, Mladinov, Mihovil, Hof, Patrick R., Šimić, Goran, and Sandi, C.
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Alzheimer's disease ,amyloid ,cognitive changes ,entorhinal cortex ,Iba1 ,microglia ,neurofibrillary changes ,rat ,stereotaxy ,tau fibrils ,tau oligomers ,tauopathy ,mental disorders - Abstract
Transgenic mouse models have been extensively used in Alzheimer’s disease (AD) research based on the amyloid hypothesis and have taken advantage of mutations in the genes for amyloid precursor protein (APP) and the presenilins (PSEN1 and PSEN2) that cause familial forms of AD. However, while these models may mimic a range of AD-related pathologies, they are limited in their ability to replicate the complex process of the sporadic human disease fully, which concerns over 95% of all AD cases. Because efforts to treat or prevent AD have been unsuccessful, there exists an urgent need for the development of new approaches for in vivo modeling of AD. As emerging evidence suggests that the spread of tau pathology in the human brain reflects the propagation of misfolded tau along anatomically connected brain regions, initiating in the brain stem and entorhinal cortex with spreading to the hippocampus and association neocortical regions, we report on a novel non- transgenic rat tauopathy model of the spreading of tau pathology observed in the human brain. The model was generated by stereotactic injections of tau proteins into the lateral entorhinal cortex of 4-month-old male Wistar rats. We assessed whether intracerebral injection of different forms of tau proteins (tau oligomers and synthetic preformed tau fibrils) would induce neurofibrillary degeneration and tau spreading in a time-dependent manner along known pathways within interconnected brain areas distant from the injection site, and whether these changes would correlate with the animals’ cognitive performance on open field, T- maze task, novel object recognition, and object- location tests. We assessed the progression of tau spreading after 4, 8, and 11 months post-injection using antibodies AT8 for hyperphosphorylated tau, and MC1 for misfolded tau, whereas possible amyloid changes were evaluated using the anti- amyloid antibody 4G8. Proteins isolated from the different ipsi- and contralateral regions to the injection site were analyzed by immunoblotting. To test for microglial uptake of tau, we also analyzed AT8 and MC1 colocalization with Iba1- expressing microglia. We discuss our results in the light of advantages and limitations of our approach in comparison to known transgenic mouse models and debate how our model may contribute to future AD preclinical testing and drug discovery.
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- 2020
48. The Emerging Role of Brain Mitochondria in Fear and Anxiety.
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Chioino A and Sandi C
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The functional complexity of brain circuits underlies the broad spectrum of behaviors, cognitive functions, and their associated disorders. Mitochondria, traditionally known for their role in cellular energy metabolism, are increasingly recognized as central to brain function and behavior. This review examines how mitochondria are pivotal in linking cellular energy processes with the functioning of neural circuits that govern fear and anxiety. Following an introductory section in which we summarize current knowledge about fear and anxiety neural circuits, we provide a brief summary of mitochondria fundamental roles (e.g., from energy production and calcium buffering to their involvement in reactive oxygen species (ROS) generation, mitochondrial dynamics, and signaling), particularly emphasizing their contribution to synaptic plasticity, neurodevelopment, and stress response mechanisms. The review's core focuses on the current state of knowledge regarding how mitochondrial function and dysfunction impact the neural substrates of fear and anxiety. Furthermore, we explore the implications of mitochondrial alterations in the context of posttraumatic stress disorder (PTSD) and anxiety disorders, underscoring the potential of mitochondrial pathways as new therapeutic targets. Integrating insights from genetic, biochemical, neurobiological, behavioral, and clinical studies, we propose a model in which mitochondrial function is critical for regulating the neural circuits that underpin fear and anxiety behaviors, highlighting how mitochondrial dysfunction can lead to their pathological manifestations. This integration emphasizes the potential for developing novel treatments targeting the biological roots of fear, anxiety, and related disorders. By merging mitochondrial biology with behavioral and circuit neuroscience, we enrich our neurobiological understanding of fear and anxiety, uncovering promising avenues for therapeutic intervention., (© 2024. The Author(s), under exclusive license to Springer Nature Switzerland AG.)
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- 2024
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49. Cognitive Training as a Shield Against Stress-Induced Working Memory Deficits.
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Sandi C
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- Humans, Cognitive Training, Memory, Short-Term physiology, Memory Disorders etiology, Memory Disorders physiopathology, Stress, Psychological
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- 2024
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50. Long term effects of peripubertal stress on the thalamic reticular nucleus of female and male mice.
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Alcaide J, Gramuntell Y, Klimczak P, Bueno-Fernandez C, Garcia-Verellen E, Guicciardini C, Sandi C, Castillo-Gómez E, Crespo C, Perez-Rando M, and Nacher J
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- Animals, Female, Male, Mice, Thalamic Nuclei metabolism, Mice, Inbred C57BL, Parvalbumins metabolism, Neurons metabolism, Prefrontal Cortex metabolism, Receptors, N-Methyl-D-Aspartate metabolism, Stress, Psychological metabolism, Stress, Psychological pathology
- Abstract
Adverse experiences during infancy and adolescence have an important and enduring effect on the brain and are predisposing factors for mental disorders, particularly major depression. This impact is particularly notable in regions with protracted development, such as the prefrontal cortex. The inhibitory neurons of this cortical region are altered by peripubertal stress (PPS), particularly in female mice. In this study we have explored whether the inhibitory circuits of the thalamus are impacted by PPS in male and female mice. This diencephalic structure, as the prefrontal cortex, also completes its development during postnatal life and is affected by adverse experiences. The long-term changes induced by PPS were exclusively found in adult female mice. We have found that PPS increases depressive-like behavior and induces changes in parvalbumin-expressing (PV+) cells of the thalamic reticular nucleus (TRN). We observed reductions in the volume of the TRN, together with those of parameters related to structures/molecules that regulate the plasticity and connectivity of PV+ cells: perineuronal nets, matricellular structures surrounding PV+ neurons, and the polysialylated form of the neural cell adhesion molecule (PSA-NCAM). The expression of the GluN1, but not of GluN2C, NMDA receptor subunit was augmented in the TRN after PPS. An increase in the fluorescence intensity of PV+ puncta was also observed in the synaptic output of TRN neurons in the lateral posterior thalamic nucleus. These results demonstrate that the inhibitory circuits of the thalamus, as those of the prefrontal cortex, are vulnerable to the effects of aversive experiences during early life, particularly in females. This vulnerability is probably related to the protracted development of the TRN and might contribute to the development of psychiatric disorders., Competing Interests: Declaration of competing interest None., (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
- Published
- 2024
- Full Text
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