Search

Your search keyword '"Sager, Hendrik B."' showing total 260 results
Start Over Author "Sager, Hendrik B." Publication Year Range Last 10 years
260 results on '"Sager, Hendrik B."'

1. DNA-sensing inflammasomes cause recurrent atherosclerotic stroke

Author

Cao, Jiayu, Roth, Stefan, Zhang, Sijia, Kopczak, Anna, Mami, Samira, Asare, Yaw, Georgakis, Marios K., Messerer, Denise, Horn, Amit, Shemer, Ruth, Jacqmarcq, Charlene, Picot, Audrey, Green, Jack P., Schlegl, Christina, Li, Xinghai, Tomas, Lukas, Dutsch, Alexander, Liman, Thomas G., Endres, Matthias, Wernsdorf, Saskia R., Fürle, Christina, Carofiglio, Olga, Zhu, Jie, Brough, David, Hornung, Veit, Dichgans, Martin, Vivien, Denis, Schulz, Christian, Dor, Yuval, Tiedt, Steffen, Sager, Hendrik B., Grosse, Gerrit M., and Liesz, Arthur

Published
2024
Full Text
View/download PDF

3. Incidence and pattern of urgent revascularization in acute coronary syndromes treated with ticagrelor or prasugrel

Author

Aytekin, Alp, Scalamogna, Maria, Coughlan, J. J., Lahu, Shqipdona, Ndrepepa, Gjin, Menichelli, Maurizio, Mayer, Katharina, Wöhrle, Jochen, Bernlochner, Isabell, Witzenbichler, Bernhard, Hochholzer, Willibald, Sibbing, Dirk, Angiolillo, Dominick J., Hemetsberger, Rayyan, Tölg, Ralph, Valina, Christian, Müller, Arne, Kufner, Sebastian, Liebetrau, Christoph, Xhepa, Erion, Hapfelmeier, Alexander, Sager, Hendrik B., Joner, Michael, Richardt, Gert, Laugwitz, Karl-Ludwig, Neumann, Franz Josef, Schunkert, Heribert, Schüpke, Stefanie, Kastrati, Adnan, and Cassese, Salvatore

Published
2024
Full Text
View/download PDF

7. In vivo Visualization of M2 Macrophages in the Myocardium After Myocardial Infarction (MI) Using 68Ga-NOTA-Anti-MMR Nb: Targeting Mannose Receptor (MR, CD206) on M2 Macrophages

Author

Varasteh, Zohreh, Braeuer, Miriam, Mohanta, Sarajo, Steinsiek, Anna-Lena, Habenicht, Andreas, Omidvari, Negar, Topping, Geoffrey J, Rischpler, Christoph, Weber, Wolfgang A, Sager, Hendrik B, Raes, Geert, Hernot, Sophie, and Schwaiger, Markus

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Bioengineering, Heart Disease - Coronary Heart Disease, Cardiovascular, Heart Disease, Biomedical Imaging, myocardial infarction, inflammation, M2 macrophages, reparative phase, PET, Cardiovascular medicine and haematology
Abstract

Introduction and objectivesWound healing after myocardial infarction (MI) is a dynamic and complex multiple phase process, and a coordinated cellular response is required for proper scar formation. The current paradigm suggests that pro-inflammatory monocytes infiltrate the MI zone during the initial pro-inflammatory phase and differentiate into inflammatory macrophages, and then switch their phenotypes to anti-inflammatory during the reparative phase. Visualization of the reparative phase post-MI is of great interest because it may reveal delayed resolution of inflammation, which in turn predicts adverse cardiac remodeling. Imaging of anti-inflammatory macrophages may also be used to assess therapy approaches aiming to modulate the inflammatory response in order to limit MI size. Reparative macrophages can be distinguished from inflammatory macrophages by the surface marker mannose receptor (MR, CD206). In this study we evaluated the feasibility of 68Ga-NOTA-anti-MMR Nb for imaging of MR on alternatively activated macrophages in murine MI models.MethodsWildtype and MR-knockout mice and Wistar rats were subjected to MI via permanent ligation of the left coronary artery. Non-operated or sham-operated animals were used as controls. MR expression kinetics on cardiac macrophages was measured in mice using flow cytometry. PET/CT scans were performed 1 h after intravenous injection of 68Ga-NOTA-anti-MMR Nb. Mice and rats were euthanized and hearts harvested for ex vivo PET/MRI, autoradiography, and staining. As a non-targeting negative control, 68Ga-NOTA-BCII10 was used.ResultsIn vivo-PET/CT scans showed focal radioactivity signals in the infarcted myocardium for 68Ga-NOTA-anti-MMR Nb which were confirmed by ex vivo-PET/MRI scans. In autoradiography images, augmented uptake of the tracer was observed in infarcts, as verified by the histochemistry analysis. Immunofluorescence staining demonstrated the presence and co-localization of CD206- and CD68-positive cells, in accordance to infarct zone. No in vivo or ex vivo signal was observed in the animals injected with control Nb or in the sham-operated animals. 68Ga-NOTA-anti-MMR Nb uptake in the infarcts of MR-knockout mice was negligibly low, confirming the specificity of 68Ga-NOTA-anti-MMR Nb to MR.ConclusionThis exploratory study highlights the potential of 68Ga-NOTA-anti-MMR Nb to image MR-positive macrophages that are known to play a pivotal role in wound healing that follows acute MI.

Published
2022

8. Ticagrelor or prasugrel in patients with acute coronary syndrome with off-hour versus on-hour presentation: a subgroup analysis of the ISAR-REACT 5 trial

Author

Behnes, Michael, Lahu, Shqipdona, Ndrepepa, Gjin, Menichelli, Maurizio, Mayer, Katharina, Wöhrle, Jochen, Bernlochner, Isabell, Gewalt, Senta, Witzenbichler, Bernhard, Hochholzer, Willibald, Sibbing, Dirk, Cassese, Salvatore, Angiolillo, Dominick J., Hemetsberger, Rayyan, Valina, Christian, Müller, Arne, Kufner, Sebastian, Hamm, Christian W., Xhepa, Erion, Hapfelmeier, Alexander, Sager, Hendrik B., Joner, Michael, Fusaro, Massimiliano, Richardt, Gert, Laugwitz, Karl-Ludwig, Neumann, Franz-Josef, Schunkert, Heribert, Schüpke, Stefanie, Kastrati, Adnan, and Akin, Ibrahim

Published
2023
Full Text
View/download PDF

12. Loss of soluble guanylyl cyclase in platelets contributes to atherosclerotic plaque formation and vascular inflammation

Author

Mauersberger, Carina, Sager, Hendrik B., Wobst, Jana, Dang, Tan An, Lambrecht, Laura, Koplev, Simon, Stroth, Marlène, Bettaga, Noomen, Schlossmann, Jens, Wunder, Frank, Friebe, Andreas, Björkegren, Johan L. M., Dietz, Lisa, Maas, Sanne L., van der Vorst, Emiel P. C., Sandner, Peter, Soehnlein, Oliver, Schunkert, Heribert, and Kessler, Thorsten

Published
2022
Full Text
View/download PDF

13. Índice de masa corporal y eficacia y seguridad del ticagrelor frente al prasugrel en pacientes con síndrome coronario agudo

Author

Lahu, Shqipdona, Behnes, Michael, Ndrepepa, Gjin, Neumann, Franz-Josef, Sibbing, Dirk, Bernlochner, Isabell, Menichelli, Maurizio, Mayer, Katharina, Richardt, Gert, Gewalt, Senta, Angiolillo, Dominick J., Coughlan, John Joseph, Aytekin, Alp, Witzenbichler, Bernhard, Hochholzer, Willibald, Cassese, Salvatore, Kufner, Sebastian, Xhepa, Erion, Sager, Hendrik B., Joner, Michael, Fusaro, Massimiliano, Laugwitz, Karl-Ludwig, Schunkert, Heribert, Schüpke, Stefanie, Kastrati, Adnan, and Akin, Ibrahim

Published
2022
Full Text
View/download PDF

14. Coronary no-reflow and adverse events in patients with acute myocardial infarction after percutaneous coronary intervention with current drug-eluting stents and third-generation P2Y12 inhibitors.

Author

Ndrepepa, Gjin, Cassese, Salvatore, Xhepa, Erion, Joner, Michael, Sager, Hendrik B., Kufner, Sebastian, Laugwitz, Karl-Ludwig, Schunkert, Heribert, and Kastrati, Adnan

Abstract

Background: The frequency and prognostic value of coronary no-reflow (CNR) was investigated in studies that have used an outdated reperfusion therapy in terms of stent technology and antithrombotic drugs. We assessed the association of CNR with adverse outcomes in patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI) with drug-eluting stents (DES) and newer antithrombotic drugs, ticagrelor or prasugrel. Methods: This study included 3100 patients with AMI who underwent PCI with current DES and third-generation P2Y12 inhibitors. CNR was defined as Thrombolysis in Myocardial Infarction (TIMI) blood flow grade ≤ 2 at the end of PCI. The primary end point was 1-year incidence of net adverse clinical and cerebral events—a composite end point of death of any cause, myocardial infarction, stroke or major bleeding. Results: CNR was diagnosed in 130 patients (4.2%). The primary end point occurred in 28 patients in the CNR group and 354 patients in the reflow group (cumulative incidence 23.2% and 12.8%; adjusted hazard ratio = 1.53, 95% confidence interval 1.01–2.33; P = 0.049). The 1-year incidences of death or myocardial infarction (14.6% vs. 7.6%; P = 0.003), myocardial infarction (8.8% vs. 3.9%; P = 0.007) and major bleeding (10.9% vs. 5.6%; P = 0.008) were significantly higher in patients with CNR than patients with reflow. The risk of adverse events in patients with CNR was highest within the first 30 days after PCI. Conclusion: In patients with AMI undergoing PCI with current DES and third generation P2Y12 receptor inhibitors, CNR was associated with a higher risk of adverse outcomes at 1 year. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

16. Efficacy and safety of ticagrelor versus prasugrel in smokers and nonsmokers with acute coronary syndromes

Author

Lahu, Shqipdona, Ndrepepa, Gjin, Gewalt, Senta, Schüpke, Stefanie, Pellegrini, Costanza, Bernlochner, Isabell, Aytekin, Alp, Neumann, Franz-Josef, Menichelli, Maurizio, Richardt, Gert, Cassese, Salvatore, Xhepa, Erion, Kufner, Sebastian, Sager, Hendrik B., Joner, Michael, Ibrahim, Tareq, Fusaro, Massimiliano, Laugwitz, Karl-Ludwig, Schunkert, Heribert, Kastrati, Adnan, and Mayer, Katharina

Published
2021
Full Text
View/download PDF

17. Ticagrelor or Prasugrel in Patients With Acute Coronary Syndrome and High Bleeding Risk

Author

Lahu, Shqipdona, Presch, Antonia, Ndrepepa, Gjin, Menichelli, Maurizio, Valina, Christian, Hemetsberger, Rayyan, Witzenbichler, Bernhard, Bernlochner, Isabell, Joner, Michael, Xhepa, Erion, Hapfelmeier, Alexander, Kufner, Sebastian, Rifatov, Nonglag, Sager, Hendrik B., Mayer, Katharina, Kessler, Thorsten, Laugwitz, Karl-Ludwig, Richardt, Gert, Schunkert, Heribert, Neumann, Franz-Josef, Sibbing, Dirk, Angiolillo, Dominick J., Kastrati, Adnan, and Cassese, Salvatore

Published
2022
Full Text
View/download PDF

18. Macrophages Facilitate Electrical Conduction in the Heart

Author

Hulsmans, Maarten, Clauss, Sebastian, Xiao, Ling, Aguirre, Aaron D, King, Kevin R, Hanley, Alan, Hucker, William J, Wülfers, Eike M, Seemann, Gunnar, Courties, Gabriel, Iwamoto, Yoshiko, Sun, Yuan, Savol, Andrej J, Sager, Hendrik B, Lavine, Kory J, Fishbein, Gregory A, Capen, Diane E, Da Silva, Nicolas, Miquerol, Lucile, Wakimoto, Hiroko, Seidman, Christine E, Seidman, Jonathan G, Sadreyev, Ruslan I, Naxerova, Kamila, Mitchell, Richard N, Brown, Dennis, Libby, Peter, Weissleder, Ralph, Swirski, Filip K, Kohl, Peter, Vinegoni, Claudio, Milan, David J, Ellinor, Patrick T, and Nahrendorf, Matthias

Subjects
Heart Disease, Cardiovascular, Aetiology, 2.1 Biological and endogenous factors, Animals, Connexin 43, Female, Heart Atria, Heart Conduction System, Humans, Macrophages, Male, Mice, Mice, Inbred C57BL, Middle Aged, Myocytes, Cardiac, atrioventricular node, computational modeling, connexin 43, electrical conduction, gap junctions, heart, macrophages, optogenetics, single-cell RNA-sequencing, tissue clearing, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

Organ-specific functions of tissue-resident macrophages in the steady-state heart are unknown. Here, we show that cardiac macrophages facilitate electrical conduction through the distal atrioventricular node, where conducting cells densely intersperse with elongated macrophages expressing connexin 43. When coupled to spontaneously beating cardiomyocytes via connexin-43-containing gap junctions, cardiac macrophages have a negative resting membrane potential and depolarize in synchrony with cardiomyocytes. Conversely, macrophages render the resting membrane potential of cardiomyocytes more positive and, according to computational modeling, accelerate their repolarization. Photostimulation of channelrhodopsin-2-expressing macrophages improves atrioventricular conduction, whereas conditional deletion of connexin 43 in macrophages and congenital lack of macrophages delay atrioventricular conduction. In the Cd11bDTR mouse, macrophage ablation induces progressive atrioventricular block. These observations implicate macrophages in normal and aberrant cardiac conduction.

Published
2017

19. Prediction of risk for bleeding, myocardial infarction and mortality after percutaneous coronary intervention in patients with acute coronary syndromes

Author

Ndrepepa, Gjin, Neumann, Franz-Josef, Menichelli, Maurizio, Richardt, Gert, Cassese, Salvatore, Xhepa, Erion, Kufner, Sebastian, Lahu, Shqipdona, Aytekin, Alp, Sager, Hendrik B., Joner, Michael, Ibrahim, Tareq, Müller, Arne, Fusaro, Massimiliano, Hapfelmeier, Alexander, Laugwitz, Karl-Ludwig, Schunkert, Heribert, Kastrati, Adnan, and Kasel, Markus

Published
2022
Full Text
View/download PDF

20. Coronary no-reflow and adverse events in patients with acute myocardial infarction after percutaneous coronary intervention with current drug-eluting stents and third-generation P2Y12 inhibitors

Author

Ndrepepa, Gjin, primary, Cassese, Salvatore, additional, Xhepa, Erion, additional, Joner, Michael, additional, Sager, Hendrik B., additional, Kufner, Sebastian, additional, Laugwitz, Karl-Ludwig, additional, Schunkert, Heribert, additional, and Kastrati, Adnan, additional

Published
2023
Full Text
View/download PDF

21. Pro-Angiogenic Macrophage Phenotype to Promote Myocardial Repair

Author

Ferraro, Bartolo, Leoni, Giovanna, Hinkel, Rabea, Ormanns, Steffen, Paulin, Nicole, Ortega-Gomez, Almudena, Viola, Joana R., de Jong, Renske, Bongiovanni, Dario, Bozoglu, Tarik, Maas, Sanne L., D’Amico, Michele, Kessler, Thorsten, Zeller, Tanja, Hristov, Michael, Reutelingsperger, Chris, Sager, Hendrik B., Döring, Yvonne, Nahrendorf, Matthias, Kupatt, Christian, and Soehnlein, Oliver

Published
2019
Full Text
View/download PDF

23. ADAMTS-7 Modulates Atherosclerotic Plaque Formation by Degradation of TIMP-1

Author

Sharifi, M. Amin, primary, Wierer, Michael, additional, Dang, Tan An, additional, Milic, Jelena, additional, Moggio, Aldo, additional, Sachs, Nadja, additional, von Scheidt, Moritz, additional, Hinterdobler, Julia, additional, Müller, Philipp, additional, Werner, Julia, additional, Stiller, Barbara, additional, Aherrahrou, Zouhair, additional, Erdmann, Jeanette, additional, Zaliani, Andrea, additional, Graettinger, Mira, additional, Reinshagen, Jeanette, additional, Gul, Sheraz, additional, Gribbon, Philip, additional, Maegdefessel, Lars, additional, Bernhagen, Jürgen, additional, Sager, Hendrik B., additional, Mann, Matthias, additional, Schunkert, Heribert, additional, and Kessler, Thorsten, additional

Published
2023
Full Text
View/download PDF

24. Leukocytes carryingClonal Hematopoiesis of Indeterminate Potential(CHIP) Mutations invade Human Atherosclerotic Plaques

Author

Scheidt, Moritz von, primary, Bauer, Sabine, additional, Ma, Angela, additional, Hao, Ke, additional, Kessler, Thorsten, additional, Vilne, Baiba, additional, Wang, Ying, additional, Hodonsky, Chani J., additional, Ghosh, Saikat K.B., additional, Mokry, Michal, additional, Gao, Hua, additional, Kawai, Kenji, additional, Sakamoto, Atsushi, additional, Kaiser, Juliane, additional, Bongiovanni, Dario, additional, Fleig, Julia, additional, Oldenbuettel, Lilith, additional, Chen, Zhifen, additional, Moggio, Aldo, additional, Sager, Hendrik B., additional, Hecker, Judith S., additional, Bassermann, Florian, additional, Maegdefessel, Lars, additional, Miller, Clint L., additional, Koenig, Wolfgang, additional, Zeiher, Andreas M., additional, Dimmeler, Stefanie, additional, Graw, Matthias, additional, Braun, Christian, additional, Ruusalepp, Arno, additional, Leeper, Nicholas J., additional, Kovacic, Jason C., additional, Björkegren, Johan L.M., additional, and Schunkert, Heribert, additional

Published
2023
Full Text
View/download PDF

25. Functional investigation of the coronary artery disease gene SVEP1

Author

Winkler, Michael J., Müller, Philipp, Sharifi, Amin M., Wobst, Jana, Winter, Hanna, Mokry, Michal, Ma, Lijiang, van der Laan, Sander W., Pang, Shichao, Miritsch, Benedikt, Hinterdobler, Julia, Werner, Julia, Stiller, Barbara, Güldener, Ulrich, Webb, Tom R., Asselbergs, Folkert W., Björkegren, Johan L. M., Maegdefessel, Lars, Schunkert, Heribert, Sager, Hendrik B., and Kessler, Thorsten

Published
2020
Full Text
View/download PDF

26. Ticagrelor or Prasugrel in Patients With ST-Segment–Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

Author

Aytekin, Alp, Ndrepepa, Gjin, Neumann, Franz-Josef, Menichelli, Maurizio, Mayer, Katharina, Wöhrle, Jochen, Bernlochner, Isabell, Lahu, Shqipdona, Richardt, Gert, Witzenbichler, Bernhard, Sibbing, Dirk, Cassese, Salvatore, Angiolillo, Dominick J., Valina, Christian, Kufner, Sebastian, Liebetrau, Christoph, Hamm, Christian W., Xhepa, Erion, Hapfelmeier, Alexander, Sager, Hendrik B., Wustrow, Isabel, Joner, Michael, Trenk, Dietmar, Fusaro, Massimiliano, Laugwitz, Karl-Ludwig, Schunkert, Heribert, Schüpke, Stefanie, and Kastrati, Adnan

Published
2020
Full Text
View/download PDF

27. Clinician scientists in cardiovascular medicine Position paper of the German Cardiac Society

Author

Hilgendorf, Ingo, Backs, Johannes, Baldus, Stephan, Chen, Jessy, Duncker, David, El-Armouche, Ali, Frey, Norbert, Hilfiker-Kleiner, Denise, Johnson, Victoria, Kuenzel, Stephan, Wollert, Kai C., Zeiher, Andreas, Sager, Hendrik B., Hilgendorf, Ingo, Backs, Johannes, Baldus, Stephan, Chen, Jessy, Duncker, David, El-Armouche, Ali, Frey, Norbert, Hilfiker-Kleiner, Denise, Johnson, Victoria, Kuenzel, Stephan, Wollert, Kai C., Zeiher, Andreas, and Sager, Hendrik B.

Abstract

Policy makers in academic medicine, the educational and research sectors, and industry all agree: clinician scientists, physicians engaged in research, are the key to translating and implementing innovative therapeutic concepts into clinical practice. To this end, research on cardiovascular diseases, which cause most cases of death in the world, must be prioritized. Following internal group discussions and surveying physicians working in university hospitals and affiliated research institutes, the German Cardiac Society thoroughly analyzed the current and future situation and role of clinician scientists in cardiovascular medicine. Modern cardiology at university hospitals is characterized by higher workloads with more patients, shorter hospital stays, and increasingly more complex interventions, making it difficult for physicians and department heads to combine their research interests and activities with their clinical duties and training. This position paper discusses possibilities to improve working conditions and career perspectives for clinician scientists in cardiovascular medicine.

Published
2023

28. Leukocytes carrying Clonal Hematopoiesis of Indeterminate Potential (CHIP) Mutations invade Human Atherosclerotic Plaques.

Author

CDL Onderzoek Pasterkamp, Experimentele Afd. Cardiologie 1, Child Health, Circulatory Health, von Scheidt, Moritz, Bauer, Sabine, Ma, Angela, Hao, Ke, Kessler, Thorsten, Vilne, Baiba, Wang, Ying, Hodonsky, Chani J, Ghosh, Saikat K B, Mokry, Michal, Gao, Hua, Kawai, Kenji, Sakamoto, Atsushi, Kaiser, Juliane, Bongiovanni, Dario, Fleig, Julia, Oldenbuettel, Lilith, Chen, Zhifen, Moggio, Aldo, Sager, Hendrik B, Hecker, Judith S, Bassermann, Florian, Maegdefessel, Lars, Miller, Clint L, Koenig, Wolfgang, Zeiher, Andreas M, Dimmeler, Stefanie, Graw, Matthias, Braun, Christian, Ruusalepp, Arno, Leeper, Nicholas J, Kovacic, Jason C, Björkegren, Johan L M, Schunkert, Heribert, CDL Onderzoek Pasterkamp, Experimentele Afd. Cardiologie 1, Child Health, Circulatory Health, von Scheidt, Moritz, Bauer, Sabine, Ma, Angela, Hao, Ke, Kessler, Thorsten, Vilne, Baiba, Wang, Ying, Hodonsky, Chani J, Ghosh, Saikat K B, Mokry, Michal, Gao, Hua, Kawai, Kenji, Sakamoto, Atsushi, Kaiser, Juliane, Bongiovanni, Dario, Fleig, Julia, Oldenbuettel, Lilith, Chen, Zhifen, Moggio, Aldo, Sager, Hendrik B, Hecker, Judith S, Bassermann, Florian, Maegdefessel, Lars, Miller, Clint L, Koenig, Wolfgang, Zeiher, Andreas M, Dimmeler, Stefanie, Graw, Matthias, Braun, Christian, Ruusalepp, Arno, Leeper, Nicholas J, Kovacic, Jason C, Björkegren, Johan L M, and Schunkert, Heribert

Published
2023

30. The novel coronary artery disease risk factor ADAMTS-7 modulates atherosclerotic plaque formation by degradation of TIMP-1

Author

Sharifi, M. Amin, primary, Wierer, Michael, additional, Dang, Tan An, additional, Milic, Jelena, additional, Moggio, Aldo, additional, Sachs, Nadja, additional, von Scheidt, Moritz, additional, Hinterdobler, Julia, additional, Müller, Philipp, additional, Werner, Julia, additional, Stiller, Barbara, additional, Aherrahrou, Zouhair, additional, Erdmann, Jeanette, additional, Zaliani, Andrea, additional, Graettinger, Mira, additional, Reinshagen, Jeanette, additional, Gul, Sheraz, additional, Gribbon, Philip, additional, Maegdefessel, Lars, additional, Bernhagen, Jürgen, additional, Sager, Hendrik B., additional, Mann, Matthias, additional, Schunkert, Heribert, additional, and Kessler, Thorsten, additional

Published
2023
Full Text
View/download PDF

34. Prior Myocardial Infarction and Treatment Effect of Ticagrelor Versus Prasugrel in Patients With Acute Coronary Syndromes ‐ A Post‐hoc Analysis of the ISAR‐REACT 5 Trial

Author

Lahu, Shqipdona, primary, Scalamogna, Maria, additional, Ndrepepa, Gjin, additional, Menichelli, Maurizio, additional, Valina, Christian, additional, Hemetsberger, Rayyan, additional, Witzenbichler, Bernhard, additional, Bernlochner, Isabell, additional, Joner, Michael, additional, Xhepa, Erion, additional, Hapfelmeier, Alexander, additional, Kufner, Sebastian, additional, Sager, Hendrik B., additional, Mayer, Katharina, additional, Kessler, Thorsten, additional, Laugwitz, Karl‐Ludwig, additional, Richardt, Gert, additional, Schunkert, Heribert, additional, Neumann, Franz‐Josef, additional, Kastrati, Adnan, additional, and Cassese, Salvatore, additional

Published
2022
Full Text
View/download PDF

36. Clinician Scientists in der kardiovaskulären Medizin

Author

Hilgendorf, Ingo, primary, Backs, Johannes, additional, Baldus, Stephan, additional, Chen, Jessy, additional, Duncker, David, additional, El-Armouche, Ali, additional, Frey, Norbert, additional, Hilfiker-Kleiner, Denise, additional, Johnson, Victoria, additional, Künzel, Stephan, additional, Wollert, Kai C., additional, Zeiher, Andreas, additional, and Sager, Hendrik B., additional

Published
2022
Full Text
View/download PDF

37. Association of In‐Hospital Hemoglobin Drop With Decreased Myocardial Salvage and Increased Long‐Term Mortality in Patients With Acute ST‐Segment–Elevation Myocardial Infarction

Author

Dutsch, Alexander, primary, Graesser, Christian, additional, Voll, Felix, additional, Novacek, Sophie, additional, Eggerstedt, Robert, additional, Armbruster, Nicolás López, additional, Laugwitz, Karl‐Ludwig, additional, Cassese, Salvatore, additional, Schunkert, Heribert, additional, Ndrepepa, Gjin, additional, Kastrati, Adnan, additional, Kessler, Thorsten, additional, and Sager, Hendrik B., additional

Published
2022
Full Text
View/download PDF

38. Body mass index and efficacy and safety of ticagrelor versus prasugrel in patients with acute coronary syndromes

Author

Lahu, Shqipdona, primary, Behnes, Michael, additional, Ndrepepa, Gjin, additional, Neumann, Franz-Josef, additional, Sibbing, Dirk, additional, Bernlochner, Isabell, additional, Menichelli, Maurizio, additional, Mayer, Katharina, additional, Richardt, Gert, additional, Gewalt, Senta, additional, Angiolillo, Dominick J., additional, Coughlan, John Joseph, additional, Aytekin, Alp, additional, Witzenbichler, Bernhard, additional, Hochholzer, Willibald, additional, Cassese, Salvatore, additional, Kufner, Sebastian, additional, Xhepa, Erion, additional, Sager, Hendrik B., additional, Joner, Michael, additional, Fusaro, Massimiliano, additional, Laugwitz, Karl-Ludwig, additional, Schunkert, Heribert, additional, Schüpke, Stefanie, additional, Kastrati, Adnan, additional, and Akin, Ibrahim, additional

Published
2022
Full Text
View/download PDF

39. Access Route and Clinical Outcomes After Ticagrelor Versus Prasugrel in Patients With Acute Coronary Syndrome Undergoing Invasive Treatment Strategy

Author

Hemetsberger, Rayyan, primary, Richardt, Gert, additional, Lahu, Shqipdona, additional, Valina, Christian, additional, Menichelli, Maurizio, additional, Abdelghani, Mohammad, additional, Wöhrle, Jochen, additional, Toelg, Ralph, additional, Witzenbichler, Bernhard, additional, Mankerious, Nader, additional, Liebetrau, Christoph, additional, Bernlochner, Isabell, additional, Hamm, Christian W., additional, Allali, Abdelhakim, additional, Joner, Michael, additional, Fusaro, Massimiliano, additional, Xhepa, Erion, additional, Hapfelmeier, Alexander, additional, Kufner, Sebastian, additional, Sager, Hendrik B., additional, Schüpke, Stefanie, additional, Laugwitz, Karl-Ludwig, additional, Schunkert, Heribert, additional, Neumann, Franz-Josef, additional, Kastrati, Adnan, additional, and Cassese, Salvatore, additional

Published
2022
Full Text
View/download PDF

40. Ticagrelor or prasugrel in patients with acute coronary syndrome with off-hour versus on-hour presentation: a subgroup analysis of the ISAR-REACT 5 trial

Author

Behnes, Michael, primary, Lahu, Shqipdona, additional, Ndrepepa, Gjin, additional, Menichelli, Maurizio, additional, Mayer, Katharina, additional, Wöhrle, Jochen, additional, Bernlochner, Isabell, additional, Gewalt, Senta, additional, Witzenbichler, Bernhard, additional, Hochholzer, Willibald, additional, Sibbing, Dirk, additional, Cassese, Salvatore, additional, Angiolillo, Dominick J., additional, Hemetsberger, Rayyan, additional, Valina, Christian, additional, Müller, Arne, additional, Kufner, Sebastian, additional, Hamm, Christian W., additional, Xhepa, Erion, additional, Hapfelmeier, Alexander, additional, Sager, Hendrik B., additional, Joner, Michael, additional, Fusaro, Massimiliano, additional, Richardt, Gert, additional, Laugwitz, Karl-Ludwig, additional, Neumann, Franz-Josef, additional, Schunkert, Heribert, additional, Schüpke, Stefanie, additional, Kastrati, Adnan, additional, and Akin, Ibrahim, additional

Published
2022
Full Text
View/download PDF

41. Colchicine Impacts Leukocyte Trafficking in Atherosclerosis and Reduces Vascular Inflammation

Author

Meyer-Lindemann, Ulrike, primary, Mauersberger, Carina, additional, Schmidt, Anna-Christina, additional, Moggio, Aldo, additional, Hinterdobler, Julia, additional, Li, Xinghai, additional, Khangholi, David, additional, Hettwer, Jan, additional, Gräßer, Christian, additional, Dutsch, Alexander, additional, Schunkert, Heribert, additional, Kessler, Thorsten, additional, and Sager, Hendrik B., additional

Published
2022
Full Text
View/download PDF

43. In vivo Visualization of M2 Macrophages in the Myocardium After Myocardial Infarction (MI) Using 68 Ga-NOTA-Anti-MMR Nb: Targeting Mannose Receptor (MR, CD206) on M2 Macrophages.

Author

Varasteh, Zohreh, Varasteh, Zohreh, Braeuer, Miriam, Mohanta, Sarajo, Steinsiek, Anna-Lena, Habenicht, Andreas, Omidvari, Negar, Topping, Geoffrey J, Rischpler, Christoph, Weber, Wolfgang A, Sager, Hendrik B, Raes, Geert, Hernot, Sophie, Schwaiger, Markus, Varasteh, Zohreh, Varasteh, Zohreh, Braeuer, Miriam, Mohanta, Sarajo, Steinsiek, Anna-Lena, Habenicht, Andreas, Omidvari, Negar, Topping, Geoffrey J, Rischpler, Christoph, Weber, Wolfgang A, Sager, Hendrik B, Raes, Geert, Hernot, Sophie, and Schwaiger, Markus

Abstract

Introduction and objectivesWound healing after myocardial infarction (MI) is a dynamic and complex multiple phase process, and a coordinated cellular response is required for proper scar formation. The current paradigm suggests that pro-inflammatory monocytes infiltrate the MI zone during the initial pro-inflammatory phase and differentiate into inflammatory macrophages, and then switch their phenotypes to anti-inflammatory during the reparative phase. Visualization of the reparative phase post-MI is of great interest because it may reveal delayed resolution of inflammation, which in turn predicts adverse cardiac remodeling. Imaging of anti-inflammatory macrophages may also be used to assess therapy approaches aiming to modulate the inflammatory response in order to limit MI size. Reparative macrophages can be distinguished from inflammatory macrophages by the surface marker mannose receptor (MR, CD206). In this study we evaluated the feasibility of 68Ga-NOTA-anti-MMR Nb for imaging of MR on alternatively activated macrophages in murine MI models.MethodsWildtype and MR-knockout mice and Wistar rats were subjected to MI via permanent ligation of the left coronary artery. Non-operated or sham-operated animals were used as controls. MR expression kinetics on cardiac macrophages was measured in mice using flow cytometry. PET/CT scans were performed 1 h after intravenous injection of 68Ga-NOTA-anti-MMR Nb. Mice and rats were euthanized and hearts harvested for ex vivo PET/MRI, autoradiography, and staining. As a non-targeting negative control, 68Ga-NOTA-BCII10 was used.ResultsIn vivo-PET/CT scans showed focal radioactivity signals in the infarcted myocardium for 68Ga-NOTA-anti-MMR Nb which were confirmed by ex vivo-PET/MRI scans. In autoradiography images, augmented uptake of the tracer was observed in infarcts, as verified by the histochemistry analysis. Immunofluorescence staining demonstrated the presence and co-localization of CD206- and CD68-positive cells, in accor

Published
2022

44. In vivo Visualization of M2 Macrophages in the Myocardium After Myocardial Infarction (MI) Using 68Ga-NOTA-Anti-MMR Nb: Targeting Mannose Receptor (MR, CD206) on M2 Macrophages

Author

Varasteh, Zohreh, primary, Braeuer, Miriam, additional, Mohanta, Sarajo, additional, Steinsiek, Anna-Lena, additional, Habenicht, Andreas, additional, Omidvari, Negar, additional, Topping, Geoffrey J., additional, Rischpler, Christoph, additional, Weber, Wolfgang A., additional, Sager, Hendrik B., additional, Raes, Geert, additional, Hernot, Sophie, additional, and Schwaiger, Markus, additional

Published
2022
Full Text
View/download PDF

45. In vivo Visualization of M2 Macrophages in the Myocardium After Myocardial Infarction (MI) Using ⁶⁸Ga-NOTA-Anti-MMR Nb : Targeting Mannose Receptor (MR, CD206) on M2 Macrophages

Author

Varasteh, Zohreh, Braeuer, Miriam, Mohanta, Sarajo, Steinsiek, Anna-Lena, Habenicht, Andreas, Omidvari, Negar, Topping, Geoffrey J., Rischpler, Christoph, Weber, Wolfgang A., Sager, Hendrik B., Raes, Geert, Hernot, Sophie, and Schwaiger, Markus

Subjects
Medizin
Abstract

Introduction and Objectives: Wound healing after myocardial infarction (MI) is a dynamic and complex multiple phase process, and a coordinated cellular response is required for proper scar formation. The current paradigm suggests that pro-inflammatory monocytes infiltrate the MI zone during the initial pro-inflammatory phase and differentiate into inflammatory macrophages, and then switch their phenotypes to anti-inflammatory during the reparative phase. Visualization of the reparative phase post-MI is of great interest because it may reveal delayed resolution of inflammation, which in turn predicts adverse cardiac remodeling. Imaging of anti-inflammatory macrophages may also be used to assess therapy approaches aiming to modulate the inflammatory response in order to limit MI size. Reparative macrophages can be distinguished from inflammatory macrophages by the surface marker mannose receptor (MR, CD206). In this study we evaluated the feasibility of ⁶⁸Ga-NOTA-anti-MMR Nb for imaging of MR on alternatively activated macrophages in murine MI models. Methods: Wildtype and MR-knockout mice and Wistar rats were subjected to MI via permanent ligation of the left coronary artery. Non-operated or sham-operated animals were used as controls. MR expression kinetics on cardiac macrophages was measured in mice using flow cytometry. PET/CT scans were performed 1 h after intravenous injection of ⁶⁸Ga-NOTA-anti-MMR Nb. Mice and rats were euthanized and hearts harvested for ex vivo PET/MRI, autoradiography, and staining. As a non-targeting negative control, ⁶⁸Ga-NOTA-BCII10 was used. Results: In vivo-PET/CT scans showed focal radioactivity signals in the infarcted myocardium for ⁶⁸Ga-NOTA-anti-MMR Nb which were confirmed by ex vivo-PET/MRI scans. In autoradiography images, augmented uptake of the tracer was observed in infarcts, as verified by the histochemistry analysis. Immunofluorescence staining demonstrated the presence and co-localization of CD206- and CD68-positive cells, in accordance to infarct zone. No in vivo or ex vivo signal was observed in the animals injected with control Nb or in the sham-operated animals. ⁶⁸Ga-NOTA-anti-MMR Nb uptake in the infarcts of MR-knockout mice was negligibly low, confirming the specificity of ⁶⁸Ga-NOTA-anti-MMR Nb to MR. Conclusion: This exploratory study highlights the potential of ⁶⁸Ga-NOTA-anti-MMR Nb to image MR-positive macrophages that are known to play a pivotal role in wound healing that follows acute MI. CA Varasteh

Published
2022

46. Pre-admission antiplatelet therapy and treatment effect of ticagrelor vs. prasugrel in patients with acute coronary syndromes—a subgroup analysis of the ISAR-REACT 5 trial

Author

Lahu, Shqipdona, primary, Ndrepepa, Gjin, additional, Neumann, Franz-Josef, additional, Menichelli, Maurizio, additional, Bernlochner, Isabell, additional, Richardt, Gert, additional, Wöhrle, Jochen, additional, Witzenbichler, Bernhard, additional, Hemetsberger, Rayyan, additional, Mayer, Katharina, additional, Akin, Ibrahim, additional, Cassese, Salvatore, additional, Gewalt, Senta, additional, Xhepa, Erion, additional, Kufner, Sebastian, additional, Valina, Christian, additional, Sager, Hendrik B, additional, Joner, Michael, additional, Ibrahim, Tareq, additional, Laugwitz, Karl-Ludwig, additional, Schunkert, Heribert, additional, Schüpke, Stefanie, additional, and Kastrati, Adnan, additional

Published
2022
Full Text
View/download PDF

47. Mental health-related risk factors and interventions in patients with heart failure: a position paper endorsed by the European Association of Preventive Cardiology (EAPC)

Author

Ladwig, Karl-Heinz, primary, Baghai, Thomas C, additional, Doyle, Frank, additional, Hamer, Mark, additional, Herrmann-Lingen, Christoph, additional, Kunschitz, Evelyn, additional, Lemogne, Cédric, additional, Beresnevaite, Margarita, additional, Compare, Angelo, additional, von Känel, Roland, additional, Sager, Hendrik B, additional, and Kop, Willem Johan, additional

Published
2022
Full Text
View/download PDF

50. Assessment of Impact of Patient Recruitment Volume on Risk Profile, Outcomes, and Treatment Effect in a Randomized Trial of Ticagrelor Versus Prasugrel in Acute Coronary Syndromes

Author

Ndrepepa, Gjin, primary, Neumann, Franz‐Josef, additional, Menichelli, Maurizio, additional, Bernlochner, Isabell, additional, Richardt, Gert, additional, Wöhrle, Jochen, additional, Witzenbichler, Bernhard, additional, Mayer, Katharina, additional, Cassese, Salvatore, additional, Gewalt, Senta, additional, Xhepa, Erion, additional, Kufner, Sebastian, additional, Sager, Hendrik B., additional, Joner, Michael, additional, Ibrahim, Tareq, additional, Laugwitz, Karl‐Ludwig, additional, Schunkert, Heribert, additional, Schüpke, Stefanie, additional, and Kastrati, Adnan, additional

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results