9 results on '"Sabik L"'
Search Results
2. Abstract P1-08-06: Changes in breast cancer diagnosis and treatment after Medicaid expansion in Pennsylvania
- Author
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Spada, N, primary, Geramita, E, additional, van Londen, G, additional, and Sabik, L, additional
- Published
- 2019
- Full Text
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3. 10-dehydrogingerdione amends tramadol-elicited neurotransmitters disturbance and apoptosis in the brain of male rats by repleting non-enzymatic antioxidants.
- Author
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ELseweidy MM, Ali SI, Sabik L, and Sewilam SE
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- Rats, Male, Animals, Antioxidants pharmacology, Caspase 3, Brain, Neurotransmitter Agents, Oxidative Stress, Apoptosis, Rats, Wistar, Glutathione pharmacology, Tramadol pharmacology
- Abstract
Tramadol is analgesic medication to relief acute and chronic pain, referred to as alternative to opioid drugs however its abuse or overdosage may resulted in neuronal toxicity. This is attributed to severe fluctuations of neurotransmitters pattern along with cerebral inflammation and oxidative damage. Present work was undertaken to illustrate the cytoprotective effect of 10-dehydrogingerdione (10-DHGD) on the brain tissues of experimental rats due to Tramadol intake and its underlying mechanism. 24 male wistar rats were randomized into 4 equal groups. Group (1), received tramadol in a dose level 20 mg/kg intrapertioneal (i.p) daily for 30 days and referred to Tramadol group. Group (2), received both of 10-DHGD (10 mg/kg, orally) one hour before tramadol intake (dose as mentioned before) daily for 30 days. Group (3) received 10-DHGD only (10 mg/kg, orally) and daily for 30 days. Group (4), received no drugs and referred to control group for comparison. Tramadol significantly reduced Norepinephrin (NE), dopamine, serotonin and glutathione (reduced) contents of Cerebral cortex. lipid peroxidation, nuclear factor kappa B (NFkB), inducible nitric oxide synthase (INOS) levels and caspase-3 immunoreactivity showed however significant increase. Of note, 10-DHGD significantly increased neurotransmitters, glutathione contents while Malondialdehyde (MDA), Nitric oxide (NO), NFkB, INOS additionally caspase-3 immunoexpression showed significant decrease i.e counteracted to certain extent tramadol effect. These findings may refer to the cytoprotective potential of 10-DHGD against the neurotoxicity exerted by tramadol intake, most probably mediated via enhancement of endogenous antioxidants system., Competing Interests: Declaration of Competing Interest The authors declare no potential conflicts of interest with respect to the research, authorship and /or publication of this article., (Copyright © 2023 Elsevier B.V. All rights reserved.)
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- 2023
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4. Disparities in geographic access to medical oncologists.
- Author
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Muluk S, Sabik L, Chen Q, Jacobs B, Sun Z, and Drake C
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- Catchment Area, Health, Health Services Accessibility, Humans, Rural Population, Socioeconomic Factors, Neoplasms, Oncologists
- Abstract
Objective: The objective of this study is to identify disparities in geographic access to medical oncologists at the time of diagnosis., Data Sources/study Setting: 2014-2016 Pennsylvania Cancer Registry (PCR), 2019 CMS Base Provider Enrollment File (BPEF), 2018 CMS Physician Compare, 2010 Rural-Urban Commuting Area Codes (RUCA), and 2015 Area Deprivation Index (ADI)., Study Design: Spatial regressions were used to estimate associations between geographic access to medical oncologists, measured with an enhanced two-step floating catchment area measure, and demographic characteristics., Data Collection/extraction Methods: Medical oncologists were identified in the 2019 CMS BPEF and merged with the 2018 CMS Physician Compare. Provider addresses were converted to longitude-latitude using OpenCage Geocoder. Newly diagnosed cancer patients in each census tract were identified in the 2014-2016 PCR. Census tracts were classified based on rurality and socioeconomic status using the 2010 RUCA Codes and the 2015 ADI., Principal Findings: Large towns and rural areas were associated with spatial access ratios (SPARs) that were 6.29 lower (95% CI -16.14 to 3.57) and 14.76 lower (95% CI -25.14 to -4.37) respectively relative to urban areas. Being in the fourth ADI quartile (highest disadvantage) was associated with a 12.41 lower SPAR (95% CI -19.50 to -5.33) relative to the first quartile. The observed difference in a census tract's non-White population from the 25th (1.3%) to the 75th percentile (13.7%) was associated with a 13.64 higher SPAR (Coefficient = 1.10, 95% CI 11.89 to 15.29; p < 0.01), roughly equivalent to the disadvantage associated with living in the fourth ADI quartile, where non-White populations are concentrated., Conclusions: Rurality and low socioeconomic status were associated with lower geographic access to oncologists. The negative association between area deprivation and geographic access is of similar magnitude to the positive association between larger non-White populations and access. Policies aimed at increasing geographic access to care should be cognizant of both rurality and socioeconomic status., (© 2022 Health Research and Educational Trust.)
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- 2022
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5. The Association Between Area Deprivation Index and Patient-Reported Outcomes in Patients with Advanced Cancer.
- Author
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Rosenzweig MQ, Althouse AD, Sabik L, Arnold R, Chu E, Smith TJ, Smith K, White D, and Schenker Y
- Abstract
Background: This analysis describes associations between area deprivation and patient-reported outcomes among patients with advanced cancer. Methods: This is a cross-sectional analysis of baseline data from a multisite primary palliative care intervention trial. Participants were adult patients with advanced cancer. Patient-level area deprivation scores were calculated using the Area Deprivation Index (ADI). Quality of life and symptom burden were measured. Uni- and multivariate regressions estimated associations between area deprivation and outcomes of interest. Results: Among 672 patients, ∼0.5 (54%) were women and most (94%) were Caucasian. Mean age was 69.3±10.2 years. Lung (36%), breast (13%), and colon (10%) were the most common malignancies. Mean ADI was 64.0, scale of 1 (low)-100 (high). In unadjusted univariate analysis, Functional Assessment of Cancer Therapy-Palliative ( p =0.002), Edmonton Symptom Assessment Scale ( p =0.025) and the Hospital Anxiety and Depression Scale anxiety ( p =0.003) and depression ( p =0.029) scores were significantly associated with residence in more deprived areas ( p =0.003). In multivariate analysis, controlling for patient-level factors, living in more deprived areas was associated with more anxiety ( p =0.019). Conclusion: Higher ADI was associated with higher levels of anxiety among patients with advanced cancer. Geographic information could assist clinicians with providing geographically influenced social support strategies., Competing Interests: No competing financial interests exist., (© Margaret Quinn Rosenzweig et al., 2021; Published by Mary Ann Liebert, Inc.)
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- 2021
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6. Effect of Medicaid Expansions of 2014 on Overall and Early-Stage Cancer Diagnoses.
- Author
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Soni A, Simon K, Cawley J, and Sabik L
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- Adult, Health Services economics, Health Services supply & distribution, Humans, Insurance Coverage legislation & jurisprudence, Medicaid legislation & jurisprudence, Middle Aged, Neoplasms diagnosis, Patient Protection and Affordable Care Act, Public Health, SEER Program, United States epidemiology, Early Detection of Cancer statistics & numerical data, Health Services Accessibility legislation & jurisprudence, Insurance Coverage statistics & numerical data, Medicaid statistics & numerical data, Neoplasms epidemiology
- Abstract
Objectives: To determine whether the 2014 Medicaid expansions facilitated by the Affordable Care Act affected overall and early-stage cancer diagnosis for nonelderly adults., Methods: We used Surveillance, Epidemiology, and End Results Cancer Registry data from 2010 through 2014 to estimate a difference-in-differences model of cancer diagnosis rates, both overall and by stage, comparing changes in county-level diagnosis rates in US states that expanded Medicaid in 2014 with those that did not expand Medicaid., Results: Among the 611 counties in this study, Medicaid expansion was associated with an increase in overall cancer diagnoses of 13.8 per 100 000 population (95% confidence interval [CI] = 0.7, 26.9), or 3.4%. Medicaid expansion was also associated with an increase in early-stage diagnoses of 15.4 per 100 000 population (95% CI = 5.4, 25.3), or 6.4%. There was no detectable impact on late-stage diagnoses., Conclusions: In their first year, the 2014 Medicaid expansions were associated with an increase in cancer diagnosis, particularly at the early stage, in the working-age population. Public Health Implications. Expanding public health insurance may be an avenue for improving cancer detection, which is associated with improved patient outcomes, including reduced mortality.
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- 2018
- Full Text
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7. Medicaid Adult Dental Benefits Increase Use Of Dental Care, But Impact Of Expansion On Dental Services Use Was Mixed.
- Author
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Singhal A, Damiano P, and Sabik L
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- Adult, Behavioral Risk Factor Surveillance System, District of Columbia, Female, Health Services Accessibility, Humans, Male, Medicaid economics, Middle Aged, Poverty, United States, Dental Care statistics & numerical data, Eligibility Determination statistics & numerical data, Insurance, Dental statistics & numerical data, Medicaid statistics & numerical data
- Abstract
Dental coverage for adult enrollees is an optional benefit under Medicaid. Thirty-one states and the District of Columbia have expanded eligibility for Medicaid under the Affordable Care Act. Millions of low-income adults have gained health care coverage and, in states offering dental benefits, oral health coverage as well. Using data for 2010 and 2014 from the Behavioral Risk Factor Surveillance System, we examined the impact of Medicaid adult dental coverage and eligibility expansions on low-income adults' use of dental care. We found that low-income adults in states that provided dental benefits beyond emergency-only coverage were more likely to have had a dental visit in the past year, compared to low-income adults in states without such benefits. Among states that provided dental benefits and expanded their Medicaid program, regression-based estimates suggest that childless adults had a significant increase (1.8 percentage points) in the likelihood of having had a dental visit, while parents had a significant decline (8.1 percentage points). One possible explanation for the disparity is that after expansion, newly enrolled childless adults might have exhausted the limited dental provider capacity that was available to parents before expansion. Additional policy-level efforts may be needed to expand the dental care delivery system's capacity., (Project HOPE—The People-to-People Health Foundation, Inc.)
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- 2017
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8. Changes in Public Prenatal Care Coverage Options for Noncitizens Since Welfare Reform: Wide State Variation Remains.
- Author
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Green T, Hochhalter S, Dereszowska K, and Sabik L
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- Eligibility Determination legislation & jurisprudence, Female, Health Policy, Humans, Medicaid legislation & jurisprudence, Patient Protection and Affordable Care Act, Poverty, Pregnancy, Retrospective Studies, United States, Emigrants and Immigrants legislation & jurisprudence, Health Care Reform legislation & jurisprudence, Insurance Coverage statistics & numerical data, Prenatal Care statistics & numerical data
- Abstract
Before 1996, most lawfully present noncitizens were eligible for the same prenatal Medicaid benefits as U.S. citizens. However, the 1996 Personal Responsibility and Work Opportunity Reconciliation Act (PRWORA)-welfare reform-restricted benefits for certain lawful noncitizens for the first time. Welfare reform also gave states unprecedented authority to determine Medicaid eligibility. More recent federal policy changes have allowed states to cover some noncitizen pregnant women initially excluded under welfare reform. However, there are few comprehensive studies examining state implementation of these policy options. This study documents state-level trends in prenatal Medicaid and state-funded coverage options for low-income noncitizens just prior to and since welfare reform. While some states have substantially expanded prenatal coverage since PRWORA, wide variation remains. These findings have important implications for understanding the potential effects of the Affordable Care Act and Medicaid expansion on health care utilization and birth outcomes among pregnant noncitizens., (© The Author(s) 2015.)
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- 2016
- Full Text
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9. Medicaid and CHIP Premiums and Access to Care: A Systematic Review.
- Author
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Saloner B, Hochhalter S, and Sabik L
- Subjects
- Child, Humans, Poverty, United States, Child Health Services economics, Children's Health Insurance Program organization & administration, Health Services Accessibility statistics & numerical data, Insurance, Health statistics & numerical data, Medicaid statistics & numerical data, State Health Plans
- Abstract
Background: Premiums are required in Medicaid and the Children's Health Insurance Program in many states. Effects of premiums are raised in policy debates., Objective: Our objective was to review effects of premiums on children's coverage and access., Data Sources: PubMed was used to search academic literature from 1995 to 2014., Study Selection: Two reviewers initially screened studies by using abstracts and titles, and 1 additional reviewer screened proposed studies. Included studies focused on publicly insured children, evaluated premium changes in at least 1 state/local program, and used longitudinal or repeated cross-sectional data with pre/postchange measures., Data Extraction: We identified 263 studies of which 17 met inclusion criteria., Results: Four studies examined population-level coverage effects by using national survey data, 11 studies examined trends in disenrollment and reenrollment by using administrative data, and 2 studies measured additional outcomes. No eligible studies evaluated health status effects. Increases in premiums were associated with increased disenrollment rates in 7 studies that permitted comparison. Larger premium increases and stringent enforcement tended to have larger effects on disenrollment. At a population level, premiums reduce public insurance enrollment and may increase the uninsured rate for lower-income children. Little is known about effects of premiums on spending or access to care, but 1 study reveals premiums are unlikely to yield substantial revenue., Limitations: Effect sizes were difficult to compare across studies with administrative data., Conclusions: Public insurance premiums often increase disenrollment from public insurance and may have unintended consequences on overall coverage for low-income children., (Copyright © 2016 by the American Academy of Pediatrics.)
- Published
- 2016
- Full Text
- View/download PDF
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