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Dysregulation of biological stress response, as measured by cortisol output, has been a primary candidate mechanism for how social experiences become biologically embedded. Cortisol is the primary output of the hypothalamic pituitary adrenal (HPA) axis. Cortisol levels vary systematically across the day and change in response to both sudden, acute stress experiences as well as prolonged exposure to environmental stress. Using data from 8- to 15-year-old twins in the Texas Twin Project, we investigate the extent to which genetic influences are shared across different measures of cortisol output: chronic cortisol accumulations in hair (n = 1,104), diurnal variation in salivary output (n = 488), and salivary response to a standardized, acute in-laboratory stressor (n = 537). Multivariate twin models indicate that genetic factors regulating cortisol response to the in-laboratory stressor are separable from those regulating baseline cortisol levels, naturally occurring diurnal variation in cortisol, and hair cortisol levels. These findings illustrate that novel environments can reveal unique genetic variation, reordering people in terms of their observed phenotype rather than only magnifying or mitigating preexisting differences.

Attention-Deficit Hyperactivity Disorder (ADHD) is a heterogeneous disorder that is highly impairing. Early, accurate diagnosis maximizes long-term positive outcomes for youth with ADHD. Tests of executive functioning (EF) are potential tools for screening and differential diagnosis of ADHD subtypes. However, previous research has been inconsistent regarding the specificity and magnitude of EF deficits across ADHD subtypes. Here, we advance knowledge of the EF-ADHD relationship by using: (1) dimensional latent factor models of ADHD that captures the heterogeneity of expression, and (2) a comprehensive, reliable battery of EF tasks and modeling relationships with a general factor of EF ability. We tested 1548 children and adolescents (ages 7-15 years) from the Texas Twin Project, a population-based cohort with a diverse socioeconomic and ethnic composition. We show that EF deficits were specific to the inattention domain of ADHD. Moreover, we found that the association between EF task performance and inattention was stable across sociodemographic groups. Our results demonstrate that failures of executive control are selectively manifested as covert inattentive symptoms, such as trouble with organization, forgetfulness, and distractedness, rather than overt symptoms, such as inappropriate talkativeness and interruption. Future research, utilizing a bifactor characterization of ADHD in clinical samples, is needed to further refine understanding of the nature of cognitive deficits in ADHD across the full range of symptom variation.

Measurements of oxygen abundance throughout galaxies provide insight to the formation histories and ongoing processes. Here we present a study of the gas-phase oxygen abundance in the H ii regions and diffuse gas of the nearby starburst dwarf galaxy, IC 10. Using the Keck Cosmic Web Imager at W. M. Keck Observatory, we map the central region of IC 10 from 3500 to 5500 Å. The auroral [O III ] 4363 Å line is detected with a high signal-to-noise ratio in 12 of 46 H II regions observed, allowing for direct measurement of the oxygen abundance, yielding a median and standard deviation of $12+\mathrm{log}({\rm{O}}/{\rm{H}})=8.37\pm 0.25$ . We investigate trends between these directly measured oxygen abundances and other H II region properties, finding weak negative correlations with the radius, velocity dispersion, and luminosity. We also find weak negative correlations between the oxygen abundance and the derived quantities of turbulent pressure and ionized gas mass, and a moderate correlation with the derived dynamical mass. Strong line, R _23 abundance estimates are used in the remainder of the H II regions and on a resolved spaxel-by-spaxel basis. There is a large offset between the abundances measured with R _23 and the auroral line method. We find that the R _23 method is unable to capture the large range of abundances observed via the auroral line measurements. The extent of this variation in the measured abundances further indicates a poorly mixed interstellar medium in IC 10, which is not typical of dwarf galaxies and may be partly due to the ongoing starburst, accretion of pristine gas, or a late stage merger.

We present results from the Quasar hosts Unveiled by high Angular Resolution Techniques survey studying the circumgalactic medium (CGM) by observing rest-frame UV emission lines Ly α , C iv , and He ii around two radio-loud quasars, 3C 9 ( z = 2.02) and 4C 05.84 ( z = 2.32), using the Keck Cosmic Web Imager. We detect large-scale Ly α nebulae around both quasars with projected diameters ∼100 kpc, with spatially resolved, embedded 15–30 kpc He ii and C iv nebulae around both quasars as well as kinematically distinct He ii and C iv nebulae at a physical separation of ∼15 kpc from both quasars. Observations of H α , H β , and [O iii ] emission using Keck MOSFIRE spectroscopically confirm that the Ly α nebulae extend to companion galaxies and that these quasars are in a protogroup/protocluster environment. We confirm that the He ii and C iv emission is kinematically and spatially coincident with the companion galaxies. We estimate the virial masses of the companion galaxies, their metallicities, and star formation rates, and investigate the sources of ionization. We measure the dynamical mass of the host dark matter halos and estimate that the dark matter halos of these systems will grow to a mass of 2 × 10 ^14 M _⊙ (3C 9) and 2 × 10 ^13 M _⊙ (4C 05.84) by z = 0. The combined CGM and companion galaxies observations indicate Ly α substructure can indicate the presence of companion galaxies in the CGM.

BackgroundWilliams syndrome (WS), a genetic disorder resulting from hemizygous microdeletion of chromosome 7q11.23, has emerged as a model for identifying the genetic architecture of socioemotional behavior. Common polymorphisms in GTF2I, which is found within the WS microdeletion, have been associated with reduced social anxiety in the general population. Identifying neural phenotypes affected by these polymorphisms would help advance our understanding not only of this specific genetic association but also of the broader neurogenetic mechanisms of variability in socioemotional behavior.MethodsThrough an ongoing parent protocol, the Duke Neurogenetics Study, we measured threat-related amygdala reactivity to fearful and angry facial expressions using functional magnetic resonance imaging, assessed trait personality using the Revised NEO Personality Inventory, and imputed GTF2I rs13227433 from saliva-derived DNA using custom Illumina arrays. Participants included 808 non-Hispanic Caucasian, African American, and Asian university students.ResultsThe GTF2I rs13227433 AA genotype, previously associated with lower social anxiety, predicted decreased threat-related amygdala reactivity. An indirect effect of GTF2I genotype on the warmth facet of extraversion was mediated by decreased threat-related amygdala reactivity in women but not men.ConclusionsA common polymorphism in the WS gene GTF2I associated with reduced social anxiety predicts decreased threat-related amygdala reactivity, which mediates an association between genotype and increased warmth in women. These results are consistent with reduced threat-related amygdala reactivity in WS and suggest that common variation in GTF2I contributes to broader variability in socioemotional brain function and behavior, with implications for understanding the neurogenetic bases of WS as well as social anxiety.

Background: Due to their overlapping clinical and histopathological features, the definitive diagnosis of papulosquamous skin diseases can only be made through clinicohistopathological association. Methods: Over a period of 18 months, we studied 100 patients with clinically suspected non-infectious papulosquamous skin lesions. Diagnosis was confirmed through histopathological examination using haematoxylin and eosin stain. The clinical pattern was associated with histopathological findings. Results: The results showed that the majority of the patients were in the age group of 21–30 years, with a male preponderance. The upper limbs were the most frequently involved site. Psoriasis was the most common papulosquamous skin disease, followed by lichen planus, pityriasis rosea, pityriasis rubra pilaris, lichen nitidus, pityriasis lichenoides, lichen striatus and parapsoriasis. Psoriasiform reaction was found to be more common than lichenoid tissue reaction. The study demonstrated a positive clinicohistopathological association in 86% of cases. Conclusions: Histopathology confirmed the diagnosis in 86% of cases, provided the diagnosis in 6% of cases and was non-contributory in 8% of cases. [ABSTRACT FROM AUTHOR]

Aim: The aim of this study was to conduct a cross-sectional questionnaire-based survey concerning the practice of occlusal splint for treating temporomandibular disorders (TMDs) by the dental practitioners of Jabalpur. Materials and Methods: A questionnaire containing questions on diagnosis, treatment, and management of TMD was given to a total of 157 general dental practitioners in Jabalpur. The responses were collected; data analysis was done by Chi-square test. Results: Of the General Dental Practitioner's, nearly 78% of participants did not attend any continuing dental education on TMD per year. More than 10 years of experience (82%) was associated with increase in positive response for treatment of TMD patient. Both the diagnosis and treatment of TMD patient were done using combination methods. The duration of splint use was considered patient dependent (42.27%) irrespective of the years of practice. Soft splint was most commonly employed for treatment, and fabrication of splint was done on hinge and mean value articulator. Conclusion: The knowledge of occlusal splint by general practitioners was found to be insufficient for treating TMDs.

Most analysts view the United Nations as a positive stabilising force in international affairs. In this paper, I critically assess this opinion of the UN’s peace enforcement actions using the case studies of the Korean War and the Gulf War while relying on the non-aggression axiom of libertarian philosophy. In the process, I shed light on some of the moral considerations at play when deciding on UN-sanctioned military intervention.

Introduction: Pulpotomy technique is most widely accepted clinical procedure for treating primary teeth with coronal pulp inflammation caused by caries with no involvement of the radicular pulp. Aim and Objective: The aim of the study was to evaluate the success and efficacy of mineral trioxide aggregate (MTA) and antioxidant mix as pulpotomy agents both clinically and radiographically. Materials and Methods: A total of forty primary molars in children aged between 6 and 9 years, requiring for pulpotomy procedures, were selected. Random samples distribution was done, antioxidant mix (n = 20) and MTA (n = 20) both were used as pulpotomy agent. Under rubber dam isolation, pulpotomy procedure was performed in all samples followed by restoration with stainless steel crowns. Later, the patients were recalled after 6 and 12 months for clinical and radiographic evaluation. The data were evaluated using Fisher's exact test. Results: Statistically analysis shows no significant difference between the two groups (P > 0.05) with respect to clinical and radiographic success rate, but antioxidant mix showed more efficient result than MTA. Conclusion: Antioxidant mix pulpotomy is more biocompatible and cost effective than any other commercially available medicament.

Reticulate pigmentary disorders (RPDs) are a group of rare autosomal dominant dermatoses with a distinctive clinical net-like pattern with specific arrangements and distributions in each entity. A forty-year-old female presented with asymptomatic, light and dark, macular lesions existing for over fifteen years with perioral scars and palmer pits and her twenty-year-old daughter beginning to develop similar lesions four years earlier. Cutaneous and histopathological examinations suggested a diagnosis of Dowling–Degos disease co-existent with reticulate acropigmentation of Kitamura in the mother and Dowling–Degos disease co-existent with acropigmentation of Dohi in the daughter. The co-existence of three infrequently encountered dermatoses with an irregular disease presentation within the family suggested the possibility of differing entities in the reticulate pigmentary group of disorders belonging to the diverse spectrums of the same disease. [ABSTRACT FROM AUTHOR]