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Based on the theory of energy transfer, this study analyzes the fracture mechanism of machinable ceramics, and establishes the machinable ceramic tool-workpiece-chip coupling cutting force model. Research on the brittleness removal of hard and brittle materials by indentation test. The pre-existing defects on the surface of the workpiece are subjected to tensile stress. With continuous loading on a certain point on the surface of the workpiece, the cracks begin to sprout and expand; when the critical load is loaded, the cracks become unstable; with the load continues, the conical cracks expand in an unstable state. The Hertz crack system is obtained at the end of the indentation. The crack system model is established based on indentation fracture mechanics. According to Griffith energy balance theory, different types of energy models of the crack system are established. The theoretical model of cutting force is established according to the principle of energy conservation, the tool input is equal to the energy change between crack systems. The results of turning experiments show that the main cutting force increases with the increase of the radius of the tool nose, and decreases with the increase of the tool rake angle. The calculated values of the theoretical model of cutting force in turning of hard and brittle materials are basically consistent with the experimental values.

This study aimed to evaluate the effects of delayed femoral vein ligation on the clinical outcomes of hip disarticulation. We retrospectively reviewed 20 patients with extremity tumors (10 bone tumors and 10 soft tissue sarcomas [STS]) who underwent hip disarticulation. Patients treated for hip disarticulation with synchronous femoral vein ligation (n = 10, regular surgery group) and hip disarticulation with delayed femoral vein ligation (n = 10, delayed ligation group), respectively, were enrolled in this study. The operative time and blood loss were used to evaluate the clinical outcomes. The delayed ligation group had significantly lower operative times than the regular surgery group (P < 0.05). Total, hidden, and intraoperative blood loss were all significantly lower in the delayed ligation group than in the regular surgery group (P < 0.05). However, there were no significant differences in postoperative blood loss. In conclusion, delayed femoral vein ligation could significantly reduce the operative time, hidden blood loss, and intraoperative blood loss in patients undergoing hip disarticulation.

Since the institutional translation teaching began in 1978, we can notice that translation teaching in the Chinese Mainland has undergone five distinctive stages: intuition-guided, contrast-oriented, equivalence-oriented, function-oriented and cognition-oriented. In each stage, distinct teaching approaches have been applied according to the specific teaching objectives, teaching materials, assessments and the demands of students as well as the qualities of teachers, and the teaching approaches evolved from the earlier personal experience and reflection-based teaching to the structural approach, the constructive approach and the holistic approach, crystallizing the teaching philosophy from experientialism, structuralism to constructivism and holism. In line with translation teaching practice, translation teaching researches have also developed and displayed the following features in terms of research methods: experience-based elicitation, dialectics-based deduction, experiment-based induction, interdisciplinary integration. In view of the development of translation studies and the variety of translation practice, this chapter surveys some major streams of research on translation teaching in China, providing critical comments on the previous research and outlining some future trends for translation teaching research in China. Translation teaching research informs the training of all-round translators and interpreters as well as contributes to the growth of translation studies as a discipline.

Is Frankenstein's monster coming to the realm of translation? Many scholars have voiced their concerns about the emergence of cutting-edge translation technology such as Google Neural Machine Trans...

In contrast to the increased research interest in artificial intelligence (AI) and translation, the relationship between human beings’ emotional intelligence (EI) and translation has not yet receiv...

New Prospects and Perspectives for Educating Language Mediators is a collection of 10 papers submitted to the ‘Innovation in Translation and Interpreting Teaching’ panel at the International Associ...

It is believed that breast cancer stem cells (BCSCs), like normal stem cell counterparts, have the capacity of self-renewal and differentiation. Simultaneously, estrogen receptor (ER)-negative (-) BCSCs are affected by surrounding differentiated ER-positive (+) tumor cells by virtue of paracrine signaling within the tumor micro-environment. Genistein (GEN), as a sort of phytoestrogen, can act on ER+ breast cancer cells but the role of GEN in the differentiation of neighboring ER- BCSCs has not been defined. Transwell co-culture system was utilized so as to elaborate the interaction between well-differentiated ER+ breast cancer cells (MCF-7) and ER- breast cancer stem/progenitor cells (mammospheres derived from MDA-MB-231 cells). GEN-induced differentiation of BCSCs was analyzed by mammospheres formation assay, flow cytometry and RT-PCR after a 3 day solo-culture or co-culture. We find that GEN sized 2 µM, and 40 nM, effectively promotes morphological alteration of mammospheres, reduces the ratio of subset of CD44+/CD24-/ESA+ cells and upregulates the expression of differentiated cell markers of mammospheres in co-culture system, but not in solo-culture condition. Besides, we demonstrate that the differentiation-inducing effect of GEN on mammospheres is associated with PI3K/Akt and MEK/ERK signaling pathways which are activated by amphiregulin released from ER+ cancer cells. These results indicate that GEN was able to induce the differentiation of breast cancer stem/progenitor cells through interaction with ER+ cancer cells by a paracrine mechanism.

As the blurb on p. i states, this book ‘explores how linguistic hybridity contributes to the reader's construction of the textual agents’ world-view and how it can be exploited in order to encourag...

Cancer stem cells are enriched in triple-negative breast cancer (TNBC) tumor tissues, which present strong capacities of proliferation and tumorigenicity. The present study detected the distribution of cancer stem cell markers cluster of differentiation (CD)44/CD24 and analyzed the clinical outcomes of different CD44/CD24 phenotypes in patients with TNBC. Multivariate Cox regression analyses were performed with regard to the prognostic value of cancer stem cell markers CD44/CD24, aldehyde dehydrogenase 1 and other baseline clinical characteristics, including tumor size, lymph node involved, adjuvant chemotherapy, Ki-67, breast cancer susceptibility gene 1, cellular tumor antigen p53, vimentin and basal-like status. The multivariate analyses showed that three of these factors, CD44/CD24 phenotype, basal-like status and number of lymph nodes involved, had an impact on overall survival. Furthermore, patients with CD44+/CD24− phenotype, basal-like tumors and ≥4 lymph nodes involved had a significantly worse prognosis. The expression of CD44 and CD24 was detected by double-staining immunohistochemistry, which can locate cancer stem cells individually. Overall, the present results indicated that CD44/CD24 status evaluated by double-staining immunohistochemistry constitutes an independent prognostic factor for TNBC.

The aim of this study was to establish a prognostic risk model for patients with triple negative breast cancer (TNBC). A total of 278 specimens of human TNBC tissues were investigated by immunohistochemistry for growth-arrest specific protein 6 expression, infiltrations of stromal natural killer cells and tumor-associated macrophages. According to their prognostic risk scores based on the model, patients were divided into three groups (score 0, 1-2, 3). Correlations of prognostic risk scores, clinicopathologic features and overall survival (OS) were analyzed. To study the clinical value of this stratification model in early disease recurrence or metastasis, 177 patients were screened out for further analysis. Based on disease free survival (DFS), 90 patients fell within the DFS ≤3 years group and 87 patients within the DFS ≥5 years group. We analyzed the differences in prognostic risk scores between the two groups. The prognostic risk scores were negatively related to tumor size, lymph node metastasis and P53 status (P < 0.001 for all). Patients with low prognostic risk scores had longer OS (P = 0.001). Using multivariate analysis, it was determined that TNM stage (HR = 0.432, 95% confidence interval [CI] = 0.281-0.665, P = 0.003), FOXP3 positive lymphocytes (HR = 1.712, 95% CI = 1.085-2.702, P = 0.021) and prognostic risk scores (HR = 1.340, 95% CI = 1.192-1.644, P = 0.005) were independent prognostic factors for OS. Compared with the DFS ≥5 years group, the DFS ≤3 years group patients had significantly higher prognostic risk scores (P < 0.001). In conclusion, the prognostic risk score of the model was a significant indicator of prognosis for patients with TNBC.