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195 results on '"SHETTY, RANJAN"'

2. 30-Day and 1-Year Outcomes With HYDRA Self-Expanding Transcatheter Aortic Valve: The Hydra CE Study

Author

Aidietis, Audrius, Srimahachota, Suphot, Dabrowski, Maciej, Bilkis, Vaildas, Buddhari, Wacin, Cheung, Gary S.H., Nair, Rajesh K., Mussayev, Abdurashid A., Mattummal, Shafeeq, Chandra, Praveen, Mahajan, Ajay U., Chmielak, Zbigniew, Govindan, Sajeev C., Jose, John, Hiremath, Murugesh S., Chandra, Sharad, Shetty, Ranjan, Mohanan, Sandeep, John, John F., Mehrotra, Sanjay, and Søndergaard, Lars

Published
2022
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8. Clinical Decision Support for Stroke Using Multi–view Learning Based Models for NIHSS Scores

Author

Rajan, Vaibhav, Bhattacharya, Sakyajit, Shetty, Ranjan, Sitaram, Amith, Vivek, G., Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Cao, Huiping, editor, Li, Jinyan, editor, and Wang, Ruili, editor

Published
2016
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11. NUMERICAL INVESTIGATION OF THE INFLUENCE OF THE LINK POSITIONING IN THE CORONARY STENT INSIDE THE NORMAL ARTERY: A COMPARATIVE STUDY OF TWO COMMERCIAL STENT DESIGNS.

Author

Bekal, Chandrakantha, Shenoy, Satish, and Shetty, Ranjan

Subjects
COMMERCIAL art, ARTERIES, RADIAL stresses, COMPUTED tomography, ARTERIAL injuries
Abstract

This paper investigates the performance of two commercial stent designs inside the normal artery for induced Von Mises Stress and radial displacement pattern. Investigation focuses on identifying the key design feature of the stent structure responsible for varied stress and displacement pattern. Two commercial stent designs, Supraflex (Stent S) and Yukon Choice (Stent T),are modeled using micro CT images and MIMICS® while idealized models are used for investigation. ANSYS Workbench is used to numerically expand the stent inside an idealized normal artery with inflation pressure. The stent and the artery are modeled using elastic-plastic and hyperelastic material models, respectively. The results suggest crucial influence of the link positioning in inducing an area of higher Von Mises Stress and stress gradient. The locations of a higher stress gradient are those in line with unbound stent crowns. Also, higher and uniform arterial displacement can be observed in the locations in line with the bound crown. Results also suggested a considerable difference in arterial distortion induced by two designs, causes for which can also be attributed to the differences in the link placement. The study suggests that the link connections play a crucial role in setting up stress field/radial displacement. Suitable modification of the link positioning can reduce the higher stress gradient and arterial distortion, which probably can reduce arterial injury. [ABSTRACT FROM AUTHOR]

Published
2023
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14. 30-Day and 1-Year Outcomes With HYDRA Self-Expanding Transcatheter Aortic Valve:The Hydra CE Study

Author

Aidietis, Audrius, Srimahachota, Suphot, Dabrowski, Maciej, Bilkis, Vaildas, Buddhari, Wacin, Cheung, Gary S.H., Nair, Rajesh K., Mussayev, Abdurashid A., Mattummal, Shafeeq, Chandra, Praveen, Mahajan, Ajay U., Chmielak, Zbigniew, Govindan, Sajeev C., Jose, John, Hiremath, Murugesh S., Chandra, Sharad, Shetty, Ranjan, Mohanan, Sandeep, John, John F., Mehrotra, Sanjay, Søndergaard, Lars, Aidietis, Audrius, Srimahachota, Suphot, Dabrowski, Maciej, Bilkis, Vaildas, Buddhari, Wacin, Cheung, Gary S.H., Nair, Rajesh K., Mussayev, Abdurashid A., Mattummal, Shafeeq, Chandra, Praveen, Mahajan, Ajay U., Chmielak, Zbigniew, Govindan, Sajeev C., Jose, John, Hiremath, Murugesh S., Chandra, Sharad, Shetty, Ranjan, Mohanan, Sandeep, John, John F., Mehrotra, Sanjay, and Søndergaard, Lars

Abstract

Objectives: This study sought to evaluate the 30-day and 1-year safety and performance of the Hydra transcatheter aortic valve (THV) (in the treatment of symptomatic severe aortic stenosis in patients at high or extreme surgical risk. Background: The Hydra THV is a novel repositionable self-expanding system with supra-annular bovine pericardial leaflets. Methods: The Hydra CE study was a premarket, prospective, multicenter, single-arm study conducted across 18 study centers in Europe and Asia-Pacific countries. The primary endpoint was all-cause mortality at 30 days. All endpoints were adjudicated by an independent clinical events committee. Results: A total of 157 patients (79.2 ± 7.1 years of age, 58.6% female; Society of Thoracic Surgeons score 4.7 ± 3.4%) were enrolled. Successful implantation was achieved in 94.3% cases. At 30 days, there were 11 (7.0%) deaths, including 9 (5.7%) cardiovascular deaths, of which 5 (3.2%) were device related. At 1 year, there were 23 (14.6%) deaths, including 13 (8.3%) cardiovascular deaths. At 30 days, there were significant improvement of effective orifice area (from 0.7 ± 0.2 cm2 to 1.9 ± 0.6 cm2) and mean aortic valve gradient (from 49.5 ± 18.5 mm Hg to 8.1 ± 3.7 mm Hg), which were sustained up to 1 year. Moderate or severe paravalvular leak was observed in 6.3% of patients at 30 days and 6.9% of patients at 1 year. The rate of new permanent pacemaker implantation was 11.7% at 30 days and 12.4% at 1 year. Conclusions: The Hydra CE study demonstrated that transcatheter aortic valve replacement with Hydra THV offered favorable efficacy at 1 year, providing large effective orifice area and low transvalvular gradient as well as acceptable complication rates with regard to new permanent pacemaker and paravalvular leak. (A Clinical Evaluation of the HYDRA Self Expanding Transcatheter Aortic Valve; NCT02434263)

Published
2022

21. Analysis of glycemic status in diabetes-naive patients on statins: A hospital-based cross-sectional study

Author

Thomson, Sereen, Chogtu, Bharti, Shetty, Ranjan, and Devasia, Tom

Subjects
Statins -- Patient outcomes -- Dosage and administration, Diabetics -- Drug therapy, Hyperglycemia -- Risk factors, Health
Abstract

Byline: Sereen. Thomson, Bharti. Chogtu, Ranjan. Shetty, Tom. DevasiaINTRODUCTION: Randomized controlled trials, observational studies, and meta-analysis suggest risk of hyperglycemia in patients on statins, and this association is being viewed [...]

Published
2018

22. Low high density lipoprotein cholesterol levels and acute coronary syndrome in young patients admitted at a tertiary care facility.

Author

Chakraborty, Arpita, Kumar, C. H. Sai, Prabhu, Mukhyaprana, Stanley, Weena, and Shetty, Ranjan K.

Subjects
HDL cholesterol, LDL cholesterol, ACUTE coronary syndrome, HIGH density lipoproteins, CORONARY artery disease, CHEST pain
Abstract

Background: Coronary artery disease (CAD) is a cardiovascular disease which is related to mortality and morbidity among the Indians predominantly in the older age group. But, recently CAD has been found more often in young population. Hence, our study aims to observe the outcomes based on various categories of high density lipoprotein (HDL) cholesterol levels estimated during admission at the hospital and correlate the levels of HDL cholesterol with severity of CAD as measured by Gensini score. Methods: A cross-sectional study was conducted in 151 young patients (18-45 years) who were admitted at the hospital with newly diagnosed acute coronary syndrome (ACS). Tests such as electrocardiogram, cardiac enzyme assay, hematologic and biochemical tests including fasting lipid profile levels were taken into account. Results: There was an inverse relation observed between the number of vessels involvedand HDL cholesterol levels. Those with lower levels of HDL cholesterol were more vulnerable to multi-vessel CAD. However, no association was observed between HDL cholesterol and severity of CAD as measured by Gensini score. Conclusion: In young patients with acute coronary syndrome and diminished HDL cholesterol levels had a greater number of vessels involved when compared with elevated HDL cholesterol levels group. However, low HDL cholesterol levels had no association with severity of CAD as measured by Gensini score. No statistically significant association was noticed between levels of HDL cholesterol and in hospital mortality /morbidity. [ABSTRACT FROM AUTHOR]

Published
2022
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23. Clinical evaluation of the Hydra self-expanding transcatheter aortic valve:6 month results from the GENESIS trial

Author

Chandra, Praveen, Jose, John, Mattummal, Shafeeq, Mahajan, Ajaykumar U., Govindan, Sajeev C., Makhale, Chandrashekhar N., Chandra, Sharad, Shetty, Ranjan, Mohanan, Sandeep, John, John F., Mehrotra, Sanjay, Søndergaard, Lars, Chandra, Praveen, Jose, John, Mattummal, Shafeeq, Mahajan, Ajaykumar U., Govindan, Sajeev C., Makhale, Chandrashekhar N., Chandra, Sharad, Shetty, Ranjan, Mohanan, Sandeep, John, John F., Mehrotra, Sanjay, and Søndergaard, Lars

Abstract

Objectives: To evaluate the safety and performance of the Hydra transcatheter aortic valve (THV) in the treatment of symptomatic severe aortic stenosis in patients at high or extreme surgical risk. Background: The Hydra THV (Vascular Innovations Co. Ltd., Nonthaburi, Thailand) is a novel flexible repositionable self-expanding system with supra-annular bovine pericardial leaflets, available in three sizes, covering aortic annuli between 17 and 27 mm. Methods: The GENESIS trial was a prospective, multi-center, single-arm, 6 month follow-up study conducted in India. The primary performance endpoint was device success defined as per VARC-II criteria at 30 days. The primary safety endpoint was all-cause mortality at 30 days. All endpoints were adjudicated by an independent clinical events committee. Results: Forty high-risk patients (74.5 ± 6.7 years, 60% men; STS Score:5.6 ± 4.2%) were enrolled in 11 centres. Device success was achieved in 92.5%. The effective orifice area improved from 0.7 ± 0.2 to 2.3 ± 0.6 cm2 at 30 days and to 2.2 ± 0.7 cm2 at 6 months (p <.0001). Mean aortic valve gradient decreased from 53.5 ± 18.1 to 8.9 ± 4.9 mmHg at 30 days and to 7.6 ± 2.7 mmHg at 6 months (p <.0001). The rate of new permanent pacemaker implantation was 7.5% at 30 days, and no patient had more than mild paravalvular leak at 6 months. The 30 days and 6 month all-cause mortality was 10.0 and 17.5%, cardiovascular mortality 7.5 and 7.5%, device-related mortality 5.0 and 5.0%, respectively. No patients had stroke up to 6 months. Conclusions: The GENESIS trial demonstrated high efficacy of the self-expanding Hydra THV. The cardiovascular mortality rate of 7.5% may partly be explained by the inclusion of some centres with no or limited previous experience in transcatheter aortic valve implantation.

Published
2021

24. Clinical evaluation of the Hydra self‐expanding transcatheter aortic valve: 6 month results from the GENESIS trial

Author

Chandra, Praveen, primary, Jose, John, additional, Mattummal, Shafeeq, additional, Mahajan, Ajaykumar U., additional, Govindan, Sajeev C., additional, Makhale, Chandrashekhar N., additional, Chandra, Sharad, additional, Shetty, Ranjan, additional, Mohanan, Sandeep, additional, John, John F., additional, Mehrotra, Sanjay, additional, and Søndergaard, Lars, additional

Published
2021
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27. Respiratory variation in aortic flow peak velocity and inferior vena cava distensibility as indices of fluid responsiveness in anaesthetised and mechanically ventilated children

Author

Achar, Shreepathi, Sagar, Maddani, Shetty, Ranjan, Kini, Gurudas, Samanth, Jyothi, Nayak, Chaitra, Madhu, Vidya, and Shetty, Thara

Subjects
Blood flow -- Analysis -- Physiological aspects, Ventilators (Medical equipment) -- Usage -- Health aspects, Health
Abstract

Byline: Shreepathi. Achar, Maddani. Sagar, Ranjan. Shetty, Gurudas. Kini, Jyothi. Samanth, Chaitra. Nayak, Vidya. Madhu, Thara. Shetty Background and Aims: Dynamic parameters such as the respiratory variation in aortic flow [...]

Published
2016

39. PROSPECTIVE REAL WORLD REGISTRY FOR THE USE OF SIROLIMUS COATED BALLOON IN SMALL VESSEL DE NOVO LESIONS

Author

Parikh, Keyur H., primary, Parikh, Parth, additional, Bhatt, Parloop, additional, Gupta, Satya, additional, Baxi, Hemang, additional, Shah, Urmil, additional, Patel, Tejas, additional, Chag, Milan, additional, Dani, Sameer, additional, Shetty, Ranjan, additional, Kumar, Prathap, additional, Hiremath, Jagdish, additional, Shah, Dinesh, additional, and Doshi, Manish, additional

Published
2018
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42. Evaluation of fetal echocardiography as a routine antenatal screening tool for detection of congenital heart disease

Author

Nayak, Krishnananda, Chandra G S, Naveen, Shetty, Ranjan, and Narayan, Pratap Kumar

Subjects
Original Article
Abstract

Fetal echocardiography plays a pivotal role in identifying the congenital heart defects (CHDs) in utero. Though foetal echocardiography is mostly reserved for high risk pregnant women, its role as a routine prenatal screening tool still needs to be defined. Performing foetal echocardiography based on only these indications can lead to a significant numbers of CHD cases going undetected who will be deprived of further management leading to increased early neonatal mortalities. The aim of this study is to assess the incidence of CHDs by fetal echocardiography in an unselected population of pregnant women in comparison with pregnant women with conventional high risk factors for CHD.This study enrolled consecutive pregnant women who attended antenatal clinic between 2008 and 2012 in a tertiary care hospital. These pregnant women were categorized into two groups: high risk group included pregnant women with traditional risk factors for CHD as laid down by Pediatric Council of the American Society of Echocardiography and low risk group. Detailed fetal 2 D echocardiography was done.A total of 1,280 pregnant women were included in study. The 118 women were categorized as the high risk group while remaining 1,162 were included in the low risk group. Twenty six cases of CHDs were detected based on abnormal foetal echocardiography (20.3 per 1,000). Two of the 26 cases of CHD occurred in high risk group whereas the remaining 24 occurred in low risk pregnancy. The difference in the incidence of CHDs between the two groups was not significant statistically (P=0.76).Our study shows no difference in incidence of CHDs between pregnancies associated with high risk factors compared to low risk pregnancies. So we advocate foetal echocardiography should be included as a part of routine antenatal screening and all pregnant women irrespective of risk factors for CHDs.

Published
2016

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