1. Variants of NOS1, NOS2, and NOS3 genes in asthmatics
- Author
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H. Kawada, Cn N. Adra, Michihiro Yoshimura, S. Moro-Oka, Xq-Q. Mao, Yoshihiro Miyamoto, Hidetoshi Inoko, Y. Saitoh, T. Shirakawa, Jm M. Hopkin, Ps-S. Gao, Jf F. Kun, T. Kasamatsu, Hirofumi Yasue, Lp P. Ho, Mh H. Roberts, and Kazuwa Nakao
- Subjects
Nitric Oxide Synthase Type III ,NOS1 ,Population ,Biophysics ,Nitric Oxide Synthase Type II ,Nerve Tissue Proteins ,Minisatellite Repeats ,Nitric Oxide Synthase Type I ,Immunoglobulin E ,Biochemistry ,Reference Values ,medicine ,Humans ,education ,Promoter Regions, Genetic ,Molecular Biology ,Gene ,Alleles ,Asthma ,Genetic association ,Genetics ,education.field_of_study ,Chromosomes, Human, Pair 12 ,biology ,Chromosome Mapping ,Genetic Variation ,Cell Biology ,Odds ratio ,medicine.disease ,Introns ,United Kingdom ,Immunology ,biology.protein ,Microsatellite ,Nitric Oxide Synthase ,Chromosomes, Human, Pair 7 ,Chromosomes, Human, Pair 17 ,Microsatellite Repeats - Abstract
Nitric oxide (NO) gas concentrations are higher in expired air in asthmatics. NO is synthesized by three isoforms of NO synthase (NOS) encoded by three distinct genes, NOS1, NOS2, and NOS3. Genome-wide searches have identified linkages to asthma on chromosomes 7, 12, and 17 where these three genes are localized. No association study, however, has been reported to date. To test whether variants of NOS1, NOS2, and NOS3 relate to asthma, a genetic association study was conducted in a British population (n = 300). Intragenic microsatellite variants of NOS1 were significantly associated with asthma [odds ratio (OR) = 2.08, 95% CI: 1.20–3.57 (95% CI), P = 0.008 (Pc = 0.048)], but not with IgE levels. Neither NOS2 nor NOS3 variants showed any association with asthma nor IgE levels. These findings suggest that NOS1 variants may be a significant contributor to asthma in a British population.
- Published
- 2016