Author: "S. Glavin" / Publication Year Range: Last 10 years - Searchworks@Jio Institute Digital Library Search Results

11 results on '"S. Glavin"'

1. The Mini-CAPTAIN liquid argon time projection chamber

Author: C. Sterbenz, R. G. Van de Water, Y. Sun, E. Pantic, J. Shin, C. Mauger, L. W. Koerner, Y. Wang, A. Yarritu, M. B. Smy, G. T. Garvey, Keith Rielage, M. Gold, N. Dokania, J. Chaves, S. Locke, C. Yanagisawa, J. Yoo, W. C. Louis, M. Tzanov, Charles E. Taylor, Hui Wang, A. R. Sanchez, Todd Haines, H. S. Chen, A. Manalaysay, P. Madigan, S. Elliot, Robert Svoboda, Jeremy Danielson, I. Stancu, A. Karlin, B. Philipbar, C. McGrew, C. Callahan, Kun-Chun Lee, A. Mills, N. Kamp, N. Walsh, B. Bhandari, S. Gardiner, J. Maricic, S. M. Fernandes, R. L. Cooper, C. Grant, S. Martynenko, Veljko Radeka, G. B. Mills, J. Mirabal-Martinez, J. Bian, C. Pitcher, Elena Guardincerri, Juan Ricardo Vidal Medina, J. Y. Ji, D. L. Danielson, M. J. Martinez, V. M. Gehman, R. W. Kadel, M. Rosen, W. Ketchum, G. Sinnis, K. Bilton, E. Martin, David B. Cline, A. Olivier, W. E. Sondheim, C. E. Tull, C. E. Thorn, F. Giuliani, S. Glavin, A. Teymourian, Q. Liu, P. J. Medina, John Ramsey, A. Higuera, and D. M. Lee
Subjects: Nuclear and High Energy Physics, Physics - Instrumentation and Detectors, Physics::Instrumentation and Detectors, FOS: Physical sciences, 01 natural sciences, Atomic, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), Particle and Plasma Physics, 0103 physical sciences, Nuclear, 010306 general physics, Neutron measurement, Nuclear Experiment, Instrumentation, physics.ins-det, Mathematical physics, Physics, Time projection chamber, 010308 nuclear & particles physics, hep-ex, Center (category theory), Photon detection system, Molecular, Instrumentation and Detectors (physics.ins-det), Nuclear & Particles Physics, Liquid argon detector, Other Physical Sciences, Liquid argon, Physics::Accelerator Physics, Astronomical and Space Sciences
Abstract: This manuscript describes the commissioning of the Mini-CAPTAIN liquid argon detector in a neutron beam at the Los Alamos Neutron Science Center (LANSCE), which led to a first measurement of high-energy neutron interactions in argon. The Mini-CAPTAIN detector consists of a Time Projection Chamber (TPC) with an accompanying photomultiplier tube (PMT) array sealed inside a liquid-argon-filled cryostat. The liquid argon is constantly purified and recirculated in a closed-loop cycle during operation. The specifications and assembly of the detector subsystems and an overview of their performance in a neutron beam are reported., 21 pages, 27 figures
Published: 2021

2. First Measurement of the Total Neutron Cross Section on Argon between 100 and 800 MeV

Author: M. J. Martinez, R. W. Kadel, A. Manalaysay, W. Ketchum, C. E. Thorn, H. S. Chen, M. Gold, C. Yanagisawa, J. Yoo, J. Shin, Q. Liu, Y. Wang, D. L. Danielson, N. Walsh, I. Stancu, P. J. Medina, S. Gardiner, J. Y. Ji, E. Pantic, Charles E. Taylor, Jeremy Danielson, L. W. Koerner, C. Sterbenz, N. Kamp, Keith Rielage, N. Dokania, A. Mills, S. Fernandes, M. Tzanov, Juan Ricardo Vidal Medina, S. Glavin, W. C. Louis, J. Mirabal-Martinez, M. Rosen, S. Locke, D. M. Lee, Kun-Chun Lee, F. Giuliani, R. L. Cooper, J. Bian, Elena Guardincerri, G. Sinnis, Y. Sun, S. Martynenko, A. Olivier, Veljko Radeka, S. R. Elliott, John Ramsey, K. Bilton, Robert Svoboda, C. Mauger, A. Teymourian, David B. Cline, A. R. Sanchez, A. Higuera, E. Martin, R. G. Van de Water, C. McGrew, D. Walker, J. Maricic, J. Chaves, B. Philipbar, A. Yarritu, W. E. Sondheim, C. E. Tull, Hui Wang, Todd Haines, C. Pitcher, V. M. Gehman, B. Bhandari, G. B. Mills, M. B. Smy, C. Callahan, A. Karlin, C. Grant, and G. T. Garvey
Subjects: Physics, Physics - Instrumentation and Detectors, Argon, Time projection chamber, FOS: Physical sciences, General Physics and Astronomy, chemistry.chemical_element, Instrumentation and Detectors (physics.ins-det), Kinetic energy, 01 natural sciences, High Energy Physics - Experiment, Nuclear physics, High Energy Physics - Experiment (hep-ex), Cross section (physics), chemistry, Neutron flux, Attenuation coefficient, 0103 physical sciences, Neutron cross section, High Energy Physics::Experiment, Neutron, Nuclear Experiment (nucl-ex), Nuclear Experiment, 010306 general physics
Abstract: We report the first measurement of the neutron cross section on argon in the energy range of 100-800 MeV. The measurement was obtained with a 4.3-hour exposure of the Mini-CAPTAIN detector to the WNR/LANSCE beam at LANL. The total cross section is measured from the attenuation coefficient of the neutron flux as it traverses the liquid argon volume. A set of 2,631 candidate interactions is divided in bins of the neutron kinetic energy calculated from time-of-flight measurements. These interactions are reconstructed with custom-made algorithms specifically designed for the data in a time projection chamber the size of the Mini-CAPTAIN detector. The energy averaged cross section is $0.91 \pm{} 0.10~\mathrm{(stat.)} \pm{} 0.09~\mathrm{(sys.)}~\mathrm{barns}$. A comparison of the measured cross section is made to the GEANT4 and FLUKA event generator packages., Comment: 5 pages, 1 table, 3 figures, submitted to Physical Review Letters
Published: 2019

3. Design and performance of a 35-ton liquid argon time projection chamber as a prototype for future very large detectors

Author: A. Himmel, C. Zhang, N. McConkey, G. Sinev, O.B. Rodrigues, R. Paulos, Y. T. Tsai, J. Insler, D. Wenman, Y. Wang, D. Brailsford, H. S. Chen, Y. Sun, M. Baird, Hui Wang, Bo Yu, Yang Li, B. Kirby, I. Stancu, J. A. Nowak, J. Fowler, Maury Goodman, Thomas Strauss, R. Sharma, Joshua R. Klein, Ranjan Dharmapalan, N. J. C. Spooner, W. Sands, Z. Djurcic, G. Santucci, James Stewart, N. Nambiar, D. Stefan, A. Hahn, M. Nunes, N. Buchanan, R. Sulej, J. Hartnell, Andrew Blake, B. Carls, R. Van Berg, S. Mufson, J. Stock, Simon Lin, T. Kutter, T. Yang, G.D. Barr, M. Thiesse, N. Barros, Lester D.R. Thompson, E. Blaufuss, V. A. Kudryavtsev, David H. Adams, M. E. Convery, M. T. Graham, A. Booth, L. Greenler, M. Worcester, T. K. Warburton, S. Glavin, R. Herbst, T. Dealtry, T. R. Junk, C. A. Moura, Robert Wilson, D. Whittington, J. E. Jacobsen, G. De Geronimo, T.V. Vieira, M. Wallbank, R. A. Gomes, Xin Qian, A. Higuera, and Xingguo Li
Subjects: Cryostat, Physics - Instrumentation and Detectors, Physics::Instrumentation and Detectors, Phase (waves), FOS: Physical sciences, 01 natural sciences, Particle detector, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Optics, 0103 physical sciences, Detectors and Experimental Techniques, Neutrino oscillation, physics.ins-det, Instrumentation, Mathematical Physics, Physics, Time projection chamber, 010308 nuclear & particles physics, business.industry, Detector, Instrumentation and Detectors (physics.ins-det), Neutrino detector, Measuring instrument, business
Abstract: Liquid argon time projection chamber technology is an attractive choice for large neutrino detectors, as it provides a high-resolution active target and it is expected to be scalable to very large masses. Consequently, it has been chosen as the technology for the first module of the DUNE far detector. However, the fiducial mass required for "far detectors" of the next generation of neutrino oscillation experiments far exceeds what has been demonstrated so far. Scaling to this larger mass, as well as the requirement for underground construction places a number of additional constraints on the design. A prototype 35-ton cryostat was built at Fermi National Acccelerator Laboratory to test the functionality of the components foreseen to be used in a very large far detector. The Phase I run, completed in early 2014, demonstrated that liquid argon could be maintained at sufficient purity in a membrane cryostat. A time projection chamber was installed for the Phase II run, which collected data in February and March of 2016. The Phase II run was a test of the modular anode plane assemblies with wrapped wires, cold readout electronics, and integrated photon detection systems. While the details of the design do not match exactly those chosen for the DUNE far detector, the 35-ton TPC prototype is a demonstration of the functionality of the basic components. Measurements are performed using the Phase II data to extract signal and noise characteristics and to align the detector components. A measurement of the electron lifetime is presented, and a novel technique for measuring a track's position based on pulse properties is described., Comment: 28 pages, 12 figures, accepted by JINST
Published: 2019
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4. The DUNE Far Detector Interim Design Report Volume 1: Physics, Technology and Strategies

Author: Collaboration, D, Abi, B, Acciarri, R, Acero, M, Adamowski, M, Adams, C, Adams, D, Adamson, P, Adinolfi, M, Ahmad, Z, Albright, C, Aliaga Soplin, L, Alion, T, Alonso Monsalve, S, Alrashed, M, Alt, C, Anderson, J, Anderson, K, Andreopoulos, C, Andrews, M, Andrews, R, Ankowski, A, Anthony, J, Antonello, M, Antonova, M, Antusch, S, Aranda Fernandez, A, Ariga, A, Ariga, T, Aristizabal Sierra, D, Arrieta Diaz, E, Asaadi, J, Ascencio, M, Asner, D, Athar, M, Auger, M, Aurisano, A, Aushev, V, Autiero, D, Azfar, F, Back, A, Back, H, Back, J, Backhouse, C, Baesso, P, Bagby, L, Bai, X, Baird, M, Balantekin, B, Balasubramanian, S, Baller, B, Ballett, P, Balleyguier, L, Bambah, B, Band, H, Bansal, M, Bansal, S, Barenboim, G, Barker, G, Barnes, C, Barr, G, Barranco Monarca, J, Barros, N, Barrow, J, Bashyal, A, Basque, V, Bass, M, Bay, F, Bays, K, Bazo, J, Beacom, J, Bechetoille, E, Behera, B, Bellantoni, L, Bellettini, G, Bellini, V, Beltramello, O, Belver, D, Benekos, N, Benetti, P, Bercellie, A, Berman, E, Bernardini, P, Berner, R, Berns, H, Bernstein, R, Bertolucci, S, Betancourt, M, Bhatnagar, V, Bhattacharjee, M, Bhuyan, B, Biagi, S, Bian, J, Biery, K, Bilki, B, Bishai, M, Bitadze, A, Blackburn, T, Blake, A, Blanco Siffert, B, Blaszczyk, F, Blaufuss, E, Blazey, G, Blennow, M, Blucher, E, Bocean, V, Boffelli, F, Boissevain, J, Bolognesi, S, Bolton, T, Bonesini, M, Boone, T, Booth, A, Booth, C, Bordoni, S, Borkum, A, Boschi, T, Bour, P, Bourguille, B, Boyd, S, Boyden, D, Bracinik, J, Brailsford, D, Brandt, A, Bremer, J, Brice, S, Bromberg, C, Brooijmans, G, Brooke, J, Brown, G, Buchanan, N, Budd, H, de Holanda, P, Cai, T, Caiulo, D, Calafiura, P, Calatayud, A, Calcutt, J, Callahan, C, Calligarich, E, Calvo, E, Camilleri, L, Caminata, A, Campanelli, M, Cancelo, G, Cankocak, K, Cantini, C, Caratelli, D, Carlus, B, Carneiro, M, Caro Terrazas, I, Carroll, T, Carvallo, M, Cascella, M, Castromonte, C, Catano-Mur, E, Cavalli-Sforza, M, Cavanna, F, Cazzato, E, Centro, S, Cerati, G, Cervelli, A, Cervera Villanueva, A, Cervi, T, Chalifour, M, Chappuis, A, Chatterjee, A, Chattopadhyay, S, Chaves, J, Chen, H, Chen, M, Chen, S, Cherdack, D, Chi, C, Childress, S, Cho, K, Choubey, S, Choudhary, B, Christensen, A, Christian, D, Christodoulou, G, Christofferson, C, Church, E, Clarke, P, Coan, T, Cocco, A, Collin, G, Conley, E, Conrad, J, Convery, M, Corey, R, Corwin, L, Cotte, P, Cremonesi, L, Crespo-Anadón, J, Creus Prats, J, Cristaldo, E, Crivelli, P, Cronin-Hennessy, D, Crowley, C, Cuesta, C, Curioni, A, Cussans, D, Dabrowski, M, Dale, D, Da Motta, H, Davenne, T, Davenport, E, Davies, G, Davies, J, Davini, S, Dawson, J, De, K, Decowski, M, Dedin Neto, P, de Icaza Astiz, I, Delbart, A, Delepine, D, Delgado, M, Dell, A, de Mello Neto, J, Demuth, D, Deng, Z, Dennis, S, Densham, C, De Bonis, I, De Gouvêa, A, De Jong, P, De Lurgio, P, De Rijck, S, De Roeck, A, de Vries, J, Dharmapalan, R, Dhingra, N, Diamantopoulou, M, Diaz, F, Díaz, J, Diaz Bautista, G, Ding, P, Distefano, C, Diwan, M, Di Domizio, S, Di Giulio, L, Di Luise, S, Djurcic, Z, Doizon, F, Dokania, N, Dolinski, M, Dong, R, dos Anjos, J, Douglas, D, Drake, G, Duchesneau, D, Duffy, K, Dung, B, Dutta, D, Duvernois, M, Duyang, H, Dvornikov, O, Dwyer, D, Dye, S, Dyshkant, A, Dytman, S, Eads, M, Eberly, B, Edmunds, D, Eisch, J, Elagin, A, Elliott, S, Ellsworth, W, Elnimr, M, Emery, S, Eno, S, Ereditato, A, Escobar, C, Escudero Sanchez, L, Evans, J, Ezeribe, A, Fahey, K, Falcone, A, Falk, L, Farbin, A, Farnese, C, Farzan, Y, Fasoli, M, Fava, A, Felix, J, Fernandez-Martinez, E, Fernandez Menendez, P, Ferraro, F, Feyzi, F, Fields, L, Filkins, A, Filthaut, F, Finch, A, Fischer, O, Fitton, M, Fitzpatrick, R, Flanagan, W, Fleming, B, Flight, R, Forest, T, Fowler, J, Fox, W, Franc, J, Francis, K, Franchini, P, Franco, D, Freeman, J, Freestone, J, Fried, J, Friedland, A, Fuess, S, Furic, I, Furmanski, A, Gago, A, Gallagher, H, Gallego-Ros, A, Galymov, V, Gamberini, E, Gambetta, S, Gamble, T, Gandhi, R, Gandrajula, R, Gao, S, Garcia-Gamez, D, Gardiner, S, Gastler, D, Gehrlein, J, Gelli, B, Gendotti, A, Ghorbani-Moghaddam, Z, Ghosh, A, Gibin, D, Gil-Botella, I, Girerd, C, Giri, A, Glavin, S, Goeldi, D, Gogota, O, Gold, M, Gollapinni, S, Gollwitzer, K, Gomes, R, Gomez, L, Gomez Bermeo, L, Gomez Cadenas, J, Gong, H, Gonnella, F, Gonzalez-Cuevas, J, Goodman, M, Goodwin, O, Gorbunov, D, Goswami, S, Goudzovski, E, Grace, C, Graf, N, Graham, M, Gramellini, E, Gran, R, Grant, A, Grant, C, Grant, N, Greco, V, Green, S, Greenlee, H, Greenler, L, Greenwood, M, Greer, J, Griffith, W, Groh, M, Grudzinski, J, Grzelak, K, Guanghua, G, Guardincerri, E, Guarino, V, Guedes, G, Guenette, R, Guglielmi, A, Guo, B, Gupta, S, Gupta, V, Guthikonda, K, Gutierrez, R, Guzowski, P, Guzzo, M, Habig, A, Hackenburg, R, Hackenburg, A, Hackett, B, Hadavand, H, Haenni, R, Hahn, A, Haigh, J, Haines, T, Haiston, J, Hamernik, T, Hamilton, P, Han, J, Handler, T, Hans, S, Harris, D, Hartnell, J, Hasegawa, T, Hatcher, R, Hatzikoutelis, A, Hays, S, Hazen, E, Headley, M, Heavey, A, Heegerv, K, Heise, J, Hennessy, K, Henry, S, Hernandez, A, Hernandez-Garcia, J, Herner, K, Hewes, J, Hignight, J, Higuera, A, Hill, T, Hillier, S, Himmel, A, Hohl, C, Holin, A, Hoppe, E, Horikawa, S, Horton-Smith, G, Hostert, M, Hourlier, A, Howard, B, Howell, R, Huang, J, Hugon, J, Hurh, P, Hylen, J, Illingworth, R, Insler, J, Introzzi, G, Ioannisian, A, Izmaylov, A, Jaffe, D, James, C, James, E, Jang, C, Jediny, F, Jeong, Y, Jhingan, A, Ji, W, Jipa, A, Jiménez, S, Johnson, C, Johnson, M, Johnson, R, Johnstone, J, Jones, B, Jones, S, Joshi, J, Jostlein, H, Jung, C, Junk, T, Kaboth, A, Kadenko, I, Kamiya, F, Kamyshkov, Y, Karagiorgi, G, Karasavvas, D, Karyotakis, Y, Kasai, S, Kasetti, S, Kaur, K, Kayser, B, Kazaryan, N, Kearns, E, Keener, P, Kemp, E, Kendziora, C, Ketchum, W, Kettell, S, Khabibullin, M, Khotjantsev, A, Kim, D, Kirby, B, Kirby, M, Klein, J, Ko, Y, Kobilarcik, T, Kocaman, B, Koerner, L, Kohn, S, Koizumi, G, Koller, P, Kopylov, A, Kordosky, M, Kormos, L, Kosc, T, Kose, U, Kostelecký, V, Kothekar, K, Kramer, M, Krennrich, F, Kreslo, I, Kriesel, K, Kropp, W, Kudenko, Y, Kudryavtsev, V, Kulagin, S, Kumar, J, Kumar, L, Kumar, A, Kumbhare, S, Kuruppu, C, Kus, V, Kutter, T, Lazur, R, Lande, K, Lane, C, Lang, K, Langford, T, Lanni, F, Lasorak, P, Last, D, Lastoria, C, Laundrie, A, Lazanu, I, Le, T, Learned, J, Lebrun, P, Lee, D, Lehmann Miotto, G, Leigui de Oliveira, M, Li, Q, Li, S, Li, X, Li, Y, Li, Z, Liao, H, Lin, S, Lin, C, Linehan, R, Linhart, V, Link, J, Liptak, Z, Lissauer, D, Littenberg, L, Littlejohn, B, Liu, J, Liu, T, Lomonaco, L, Losecco, J, Lockwitz, S, Lockyer, N, Loew, T, Lokajicek, M, Long, K, Loo, K, Lopez, J, Lorca, D, Lord, T, Losada, M, Louis, W, Luethi, M, Luk, K, Lundin, T, Luo, X, Lurkin, N, Lux, T, Luzio, V, Lykken, J, Maalampi, J, Maclellan, R, Machado, A, Machado, P, Macias, C, Macier, J, Madigan, P, Magill, S, Mahler, G, Mahn, K, Malek, M, Maloney, J, Mammoliti, F, Mandal, S, Mandrioli, G, Manenti, L, Manly, S, Mann, A, Marchionni, A, Marciano, W, Marcocci, S, Marfatia, D, Mariani, C, Maricic, J, Marinho, F, Marino, A, Marshak, M, Marshall, C, Marshall, J, Marteau, J, Martin-Albo, J, Martinez, D, Martinez, N, Martinez, H, Mason, K, Mastbaum, A, Masud, M, Mathez, H, Matsuno, S, Matthews, J, Mauger, C, Mauri, N, Mavrokoridis, K, Mazza, R, Mazzacane, A, Mazzucato, E, Mccauley, N, Mccluskey, E, Mcconkey, N, Mcdonald, K, Mcfarland, K, Mcgivern, C, Mcgowan, A, Mcgrew, C, Mckeown, R, Mcnab, A, Mcnulty, D, Mctaggart, R, Meddage, V, Mefodiev, A, Mehta, P, Mei, D, Mena, O, Menary, S, Mendez, H, Mendez, D, Menegolli, A, Meng, G, Messier, M, Metcalf, W, Mewes, M, Meyer, H, Miao, T, Migenda, J, Milincic, R, Miller, J, Miller, W, Mills, J, Milne, C, Mineev, O, Miranda, O, Mishra, C, Mishra, S, Mislivec, A, Mitrica, B, Mladenov, D, Mocioiu, I, Moffat, K, Moggi, N, Mohanta, R, Mokhov, N, Molina, J, Molina Bueno, L, Montanari, A, Montanari, C, Montanari, D, Montano Zetina, L, Moon, J, Mooney, M, Moore, C, Moreno, D, Morgan, B, Moroni, G, Morris, C, Morse, W, Mossey, C, Moura, C, Mousseau, J, Mualem, L, Muether, M, Mufson, S, Muheim, F, Muramatsu, H, Murphy, S, Musser, J, Nachtman, J, Nalbandyan, M, Nandakumar, R, Naples, D, Narita, S, Navarro, G, Navarro, J, Navas-Nicolás, D, Nayak, N, Nebot-Guinot, M, Needham, M, Negishi, K, Nelson, J, Nessi, M, Newbold, D, Newcomer, M, Nichol, R, Nicholls, T, Niner, E, Norman, A, Norris, B, Norris, J, Novella, P, Nowak, E, Nowak, J, Nunes, M, O'Keeffe, H, Oberling, M, Olivares Del Campo, A, Olivier, A, Onel, Y, Onishchuk, Y, Ovsjannikova, T, Ozturk, S, Pagani, L, Pakvasa, S, Palamara, O, Paley, J, Pallavicini, M, Palomares, C, Palomino, J, Pantic, E, Paolo, A, Paolone, V, Papadimitriou, V, Papaleo, R, Paramesvaran, S, Park, J, Parke, S, Parsa, Z, Pascoli, S, Pasternak, J, Pater, J, Patrizii, L, Patterson, R, Patton, S, Patzak, T, Paudel, A, Paulos, B, Paulucci, L, Pavlovic, Z, Pawloski, G, Payam, P, Payne, D, Pec, V, Peeters, S, Pennacchio, E, Penzo, A, Perdue, G, Peres, O, Periale, L, Petridis, K, Petrillo, G, Petti, R, Picchi, P, Pickering, L, Pietropaolo, F, Pillow, J, Plonski, P, Plunkett, R, Poling, R, Pons, X, Poonthottathil, N, Popovic, M, Pordes, R, Pordes, S, Potekhin, M, Potenza, R, Potukuchi, B, Poudel, S, Pozimski, J, Pozzato, M, Prakasj, T, Preece, R, Prokofiev, O, Pruthi, N, Przewlocki, P, Psihas, F, Pugnëre, D, Pushka, D, Qi, K, Qian, X, Raaf, J, Raboanary, R, Radeka, V, Rademacker, J, Radescu, V, Radics, B, Radovic, A, Rafique, A, Rajaoalisoa, M, Rakhno, I, Rakotondramanana, H, Rakotondravohitra, L, Ramachers, Y, Rameika, R, Ramirez Delgado, M, Ramsey, J, Ramson, B, Rappoldi, A, Raselli, G, Ratoff, P, Ravat, S, Ravinez, O, Razafinime, H, Rebel, B, Redondo, D, Regenfus, C, Reggiani-Guzzo, M, Rehak, T, Reichenbacher, J, Reitzner, D, Reno, M, Renshaw, A, Rescia, S, Resnati, F, Reynolds, A, Riccobene, G, Rice, L, Rielage, K, Riesselmann, K, Rigaut, Y, Rivera, D, Rochester, L, Roda, M, Rodrigues, P, Rodriguez Alonso, M, Roe, B, Roeth, A, Roser, R, Ross-Lonergan, M, Rossella, M, Rout, J, Roy, S, Rubbia, A, Rubbia, C, Rucinski, R, Russell, B, Russell, J, Ruterbories, D, Vagins, M, Saakyan, R, Sahu, N, Sala, P, Salukvadze, G, Samios, N, Sanchez, F, Sanchez, M, Sandoval, C, Sands, B, Sankar, S, Santana, S, Santos, L, Santucci, G, Saoulidou, N, Sapienza, P, Sarasty, C, Sarcevic, I, Savage, G, Scaramelli, A, Scarpelli, A, Schaffer, T, Schellman, H, Schlabach, P, Schloesser, C, Schmitz, D, Schneps, J, Scholberg, K, Schukraft, A, Segreto, E, Sehrawat, S, Sensenig, J, Seong, I, Sepulveda-Quiroz, J, Sergi, A, Sergiampietri, F, Sessumes, D, Sexton, K, Sexton-Kennedy, L, Sgalaberna, D, Shaevitz, M, Shafaq, S, Shahi, J, Shahsavarani, S, Shanahan, P, Sharma, H, Sharma, R, Shaw, T, Shin, S, Shoemaker, I, Shooltz, D, Shrock, R, Simos, N, Sinclair, J, Sinev, G, Singh, V, Singh, J, Singh, I, Sipos, R, Sippach, F, Sirri, G, Siyeon, K, Smargianaki, D, Smith, A, Smith, E, Smith, P, Smolik, J, Smy, M, Snider, E, Snopok, P, Sobczyk, J, Sobel, H, Soderberg, M, Solano Salinas, C, Söldner-Rembold, S, Solomey, N, Sondheim, W, Sorel, M, Soto-Oton, J, Sousa, A, Soustruznik, K, Spagliardi, F, Spanu, M, Spitz, J, Spooner, N, Staley, R, Stancari, M, Stanco, L, Stefanik, A, Steiner, H, Stewart, J, Stock, J, Stocker, F, Stoica, S, Stone, J, Strait, J, Strait, M, Strauss, T, Striganov, S, Stuart, A, Sullivan, G, Sultana, M, Sun, Y, Surdo, A, Susic, V, Suter, L, Sutera, C, Svoboda, R, Szczerbinska, B, Szelc, A, Tagg, N, Talaga, R, Tanaka, H, Tapia Oregui, B, Tariq, S, Tatar, E, Tayloe, R, Tenti, M, Terao, K, Ternes, C, Terranova, F, Testera, G, Thea, A, Thompson, L, Thompson, J, Thorn, C, Timilsina, A, Timm, S, Todd, J, Tonazzo, A, Tope, T, Torbunov, D, Torti, M, Tórtola, M, Tortorici, F, Toups, M, Touramanis, C, Trevor, J, Tripathi, M, Tromeur, W, Tropin, I, Trzaska, W, Tsai, Y, Tsang, K, Tsaris, A, Tufanli, S, Tull, C, Turner, J, Tzanov, M, 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Hahn, J. Haigh, T. Haines, J. Haiston, T. Hamernik, P. Hamilton, J. Han, T. Handler, S. Hans, D. A. Harris, J. Hartnell, T. Hasegawa, R. Hatcher, A. Hatzikoutelis, S. Hays, E. Hazen, M. Headley, A. Heavey, K. Heegerv, J. Heise, K. Hennessy, S. Henry, A. Hernandez, J. Hernandez-Garcia, K. Herner, J. Hewes, J. Hignight, A. Higuera, T. Hill, S. Hillier, A. Himmel, C. Hohl, A. Holin, E. Hoppe, S. Horikawa, G. Horton-Smith, M. Hostert, A. Hourlier, B. Howard, R. Howell, J. Huang, J. Hugon, P. Hurh, J. Hylen, R. Illingworth, J. Insler, G. Introzzi, A. Ioannisian, A. Izmaylov, D. E. Jaffe, C. James, E. James, C. -H. Jang, F. Jediny, Y. S. Jeong, A. Jhingan, W. Ji, A. Jipa, S. Jiménez, C. Johnson, M. Johnson, R. Johnson, J. Johnstone, B. Jones, S. Jones, J. Joshi, H. Jostlein, C. K. Jung, T. Junk, A. Kaboth, I. Kadenko, F. Kamiya, Y. Kamyshkov, G. Karagiorgi, D. Karasavvas, Y. Karyotakis, S. Kasai, S. Kasetti, K. Kaur, B. Kayser, N. Kazaryan, E. Kearns, P. Keener, E. Kemp, C. Kendziora, W. Ketchum, S. H. Kettell, M. Khabibullin, A. Khotjantsev, D. Kim, B. Kirby, M. Kirby, J. Klein, Y. -J. Ko, T. Kobilarcik, B. Kocaman, L. W. Koerner, S. Kohn, G. Koizumi, P. Koller, A. Kopylov, M. Kordosky, L. Kormos, T. Kosc, U. Kose, V. A. Kostelecký, K. Kothekar, M. Kramer, F. Krennrich, I. Kreslo, K. Kriesel, W. Kropp, Y. Kudenko, V. A. Kudryavtsev, S. Kulagin, J. Kumar, L. Kumar, A. Kumar, S. Kumbhare, C. Kuruppu, V. Kus, T. Kutter, R. LaZur, K. Lande, C. Lane, K. Lang, T. Langford, F. Lanni, P. Lasorak, D. Last, C. Lastoria, A. Laundrie, I. Lazanu, T. Le, J. Learned, P. Lebrun, D. Lee, G. Lehmann Miotto, M. A. Leigui de Oliveira, Q. Li, S. Li, S. W. Li, X. Li, Y. Li, Z. Li, H. -Y. Liao, S. -K. Lin, C-J. S. Lin, R. Linehan, V. Linhart, J. Link, Z. Liptak, D. Lissauer, L. Littenberg, B. Littlejohn, J. Liu, T. Liu, L. LoMonaco, J. M. LoSecco, S. Lockwitz, N. Lockyer, T. Loew, M. Lokajicek, K. Long, K. Loo, J. P. Lopez, D. Lorca, T. Lord, M. Losada, W. C. Louis, M. Luethi, K. -B. Luk, T. Lundin, X. Luo, N. Lurkin, T. Lux, V. P. Luzio, J. Lykken, J. Maalampi, R. MacLellan, A. A. Machado, P. Machado, C. T. Macias, J. Macier, P. Madigan, S. Magill, G. Mahler, K. Mahn, M. Malek, J. A. Maloney, F. Mammoliti, S. K. Mandal, G. Mandrioli, L. Manenti, S. Manly, A. Mann, A. Marchionni, W. Marciano, S. Marcocci, D. Marfatia, C. Mariani, J. Maricic, F. Marinho, A. D. Marino, M. Marshak, C. Marshall, J. Marshall, J. Marteau, J. Martin-Albo, D. Martinez, N. Martinez, H. Martinez, K. Mason, A. Mastbaum, M. Masud, H. Mathez, S. Matsuno, J. Matthews, C. Mauger, N. Mauri, K. Mavrokoridis, R. Mazza, A. Mazzacane, E. Mazzucato, N. McCauley, E. McCluskey, N. McConkey, K. McDonald, K. S. McFarland, C. McGivern, A. McGowan, C. McGrew, R. McKeown, A. McNab, D. McNulty, R. McTaggart, V. Meddage, A. Mefodiev, P. Mehta, D. Mei, O. Mena, S. Menary, H. Mendez, D. P. Mendez, A. Menegolli, G. Meng, M. Messier, W. Metcalf, M. Mewes, H. Meyer, T. Miao, J. Migenda, R. Milincic, J. Miller, W. 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Wetstein, M. While, A. White, L. H. Whitehead, D. Whittington, K. Wierman, M. Wilking, C. Wilkinson, J. Willhite, Z. Williams, R. J. Wilson, P. Wilson, P. Wittich, J. Wolcott, T. Wongjirad, K. Wood, L. Wood, E. Worcester, M. Worcester, S. Wu, W. Wu, W. Xu, C. Yanagisawa, S. Yang, T. Yang, G. Yang, J. Ye, M. Yeh, N. Yershov, K. Yonehara, L. Yoshimura, B. Yu, J. Yu, J. Zalesak, L. Zambelli, B. Zamorano, A. Zani, K. Zaremba, L. Zazueta, G. P. Zeller, J. Zennamo, C. Zhang, M. Zhao, Y. -L. Zhou, G. Zhu, E. D. Zimmerman, M. Zito, S. Zucchelli, J. Zuklin, V. Zutshi, and R. Zwaska
Abstract: The DUNE IDR describes the proposed physics program and technical designs of the DUNE Far Detector modules in preparation for the full TDR to be published in 2019. It is intended as an intermediate milestone on the path to a full TDR, justifying the technical choices that flow down from the high-level physics goals through requirements at all levels of the Project. These design choices will enable the DUNE experiment to make the ground-breaking discoveries that will help to answer fundamental physics questions. Volume 1 contains an executive summary that describes the general aims of this document. The remainder of this first volume provides a more detailed description of the DUNE physics program that drives the choice of detector technologies. It also includes concise outlines of two overarching systems that have not yet evolved to consortium structures: computing and calibration. Volumes 2 and 3 of this IDR describe, for the single-phase and dual-phase technologies, respectively, each detector module's subsystems, the technical coordination required for its design, construction, installation, and integration, and its organizational structure.
Published: 2018

5. Long-Baseline Neutrino Facility (LBNF) and Deep Underground Neutrino Experiment (DUNE): Conceptual Design Report. Volume 4: The DUNE Detectors at LBNF

Author: M. Headley, V. Singh, L. L. Kormos, E. Hazen, A. Kumar, R. K. Plunkett, Christopher L. Marshall, R. Schmitt, E. Blaufuss, Amanpreet Kaur, C. Vignoli, David Malon, P vanGemmeren, A. Heavey, S. L. Mufson, J. Cushing, S. R. Elliott, A. deGouvea, F. Pietropaolo, T. Hasegawa, V. Papadimitriou, Roberto L. N. Oliveira, D. Waters, D. Ruterbories, A. Topkar, W. Honey, T. Yang, Marvin Johnson, Mingshui Chen, Carl H. Albright, M. Muether, S. Rescia, John F. Beacom, J. Johnstone, M.D.L. Lopes, A. Verdugo, L.S. Rochester, Y. Ng, Xiaohui Qian, B. Page, B. Rebel, Steven Gardiner, P. DeLurgio, Ernesto Kemp, D. Wells, C. Grant, D. Warner, D. Aristizabal, S. Bansal, T. L. Usher, Germano Guedes, D. Duchesneau, M. C. Sanchez, L. Camilleri, Joshua R. Klein, D.W. Schmitz, R. VanBerg, H. L. H. Wong, B. Viren, Mario Campanelli, J. L. Stone, B. Lundberg, O. Palamara, A. Laminack, D. Lissauer, Francesco Tortorici, M. A. Acero, T. Tope, D. Cianci, David H. Adams, C. Yanagisawa, J. Lowery, Ranjan Dharmapalan, J. Mousseau, W. R. Kropp, A. Perch, J. Moon, C. Palomares, R. Andrews, J. Hartnell, N. Kazaryan, Kendall Mahn, V. Bellini, Pomita Ghoshal, M. Adamowski, D. Girardelli, Bindu A. Bambah, Y. Nakajima, A. N. Khotjantsev, D. Reitzner, D. Smargianaki, B. Eberly, T. Liu, S. Glavin, J. Asaadi, G. d. Geronimo, M. B. Smy, M. Baird, Z. Moss, Gustaaf Brooijmans, Alessandro Menegolli, R. B. Patterson, J. A. J. Matthews, M. Weber, Dmitry Gorbunov, M. Tzanov, R. L. Talaga, S.K. Mandal, C. Greenley, G. W. Sullivan, Dimitar Mladenov, Anjan K. Giri, T. Boone, E. James, L. Fields, T. A. Bolton, S. A. Dytman, R. Rucinski, Alexander Mann, Gabriel Perdue, S. Bolognesi, B. Szczerbinska, F. Bay, R. D. McKeown, C. Lane, S. Chembra, Shu Li, Sangeeta Malhotra, D. Garcia-Gamez, R. L. Gill, B. Wang, J. Spitz, B. T. Fleming, E. McCluskey, Timothy M. Shaw, T. Patzak, S. Horikawa, Z. Pavlovic, E. Pantic, H. M. O'Keeffe, J. Anderson, A. Friedland, J. P. Lopez, R. Raboanary, P. Schlabach, J. Strait, T. A. Forest, M. D. Messier, R. Potenza, Narendra Sahu, A. M. McGowan, R. Santorelli, B. V. K. S. Potukuchi, C. Montanari, W.M. Lee, M. Toups, M. Kordosky, D. Mertins, Matthew Wetstein, Wenzhao Wei, S. Kohn, T. J. Haines, Jasvinder A. Singh, G. Introzzi, D. Naples, Kazuhiro Terao, Q. Liu, M. Potekhin, Stanley G. Wojcicki, E. Arrieta-Diaz, J. Davies, P. Novella, Andrew Blake, A. L. Renshaw, M. O. Wascko, J. Insler, Jason Kumar, C. Jen, L. Wang, G. Koizumi, M. M. Khabibullin, E. Amador, T. Grundy, Yu. Onishchuk, B. Mitrica, T. Hamernik, D. Wenman, Gianluca Petrillo, V. J. Guarino, N. McCauley, A. Tonazzo, D. J. Taylor, A. B. Balantekin, T. Nicholls, S. Jiménez, William A. Barletta, B. Zamorano, R. Saakyan, J. R. Macier, S. B. Boyd, T. Xin, J. Bremer, M. J. Wilking, M. E. Convery, R. Gran, N. Pruthi, K. J. Anderson, Enrique Calvo, Peter Wittich, Artur F. Izmaylov, J. Hylen, C. Touramanis, G. A. Valdiviesso, Irina Mocioiu, Katsuya Yonehara, C. M. Sutera, Kenneth Long, T. E. Coan, D. Autiero, H. K. Hadavand, S. Menary, J. M. Paley, Antonio Ereditato, C. Rubbia, T. Olson, O. G. Miranda, A. G. Cocco, Gary Drake, J.A. Sepulveda-Quiroz, A. Guglielmi, T. Lundin, S. Fuess, Mary S. Richardson, S. Emery, J. M. Link, Jingbo Ye, N. Yershov, H. S. Chen, Davit Mayilyan, Christian Farnese, T. Loew, M. Bansal, T. R. Junk, Y. A. Ramachers, Akitaka Ariga, Marvin L Marshak, G. Karagiorgi, Sarah Catherine Eno, William J. Marciano, Philip D Adamson, R. Vandewater, Kevin Scott McFarland, M. Torti, M. Tortola, M. Antonello, Leonidas Kalousis, S. Shahsavarani, N. Simos, S. Mandodi, B. J. P. Jones, Rob Edgecock, R. Haenni, G. Meng, H. Pessard, O. Mena, J. Dolph, L. Suter, N. Graf, Abraham D. Falcone, T. Gamble, B. Bourguille, L. Greenler, Francesco Lanni, Zulkifli Ahmad, L. A. Corwin, D. Stefan, M. V. Diwan, Joseph Lykken, E. Niner, J. K. Nelson, P. Novakova, Paulo Rodrigues, E. Blucher, L. Whitehead, S. Ventura, C. Y. Chi, I. Gil-Botella, B. Carls, Valentina Greco, N. P. Samios, M. Elnimr, B. Sands, R. Milincic, C. A. Moura, M. Newcomer, Kirk T. McDonald, J. Reichenbacher, K. Mavrokoridis, F. d. M. Blaszczyk, J. L. Raaf, Paolo Crivelli, A. Sousa, M. Mehrian, Olga Beltramello, H. Wang, K. Riesselmann, M. Nunes, M. Bergevin, M. Bass, Yu. G. Kudenko, J. H. Jo, Robert McTaggart, Georg G. Raffelt, E. Tziaferi, A. Holin, L. Valerio, A. Scaramelli, A. D. Marino, C. Rudolphvonrohr, V.M. Gehman, S. Santana, C. Mariani, K. Lande, S. Tariq, S. M. Fernandes, S. J. Brice, Gregory J Pawloski, Carlos Escobar, J. D. Perkin, S. R. Das, B. K. Fujikawa, G. T. Garvey, Sukalyan Chattopadhyay, H. Jostlein, V.B. Chandratre, M. Bonesini, J. d. Anjos, Matthew L Strait, M. C. Tamsett, J.V. Dawson, Giovanni Bellettini, G.D. Barr, Kam Biu Luk, S. Manly, M. Wallbank, Jack Fried, S. Childress, T. Miao, E. Berman, R. W. Hackenburg, H. Duyang, Cerian F Jackson, B. Baibussinov, T. K. Warburton, R. Petti, Jan T. Sobczyk, Vipin Bhatnagar, A. Aurisano, Marzio Nessi, H. Greenlee, I. Singh, H. Meyer, Michael Benjamin Andrews, A. Schukraft, A. A. Machado, Q. Z. Li, B. Norris, R. Guenette, K. Biery, Z. Li, Magdalena Malek, A. Cervera-Villanueva, M. S. Athar, P. N. Ratoff, Dongming Mei, Subrata Pal, A. Bashyal, Andrew Brandt, T. Kutter, A. Hackenburg, V. Aushev, Jorge G. Morfin, R. Tsenov, R. Kriske, Sergey A. Kulagin, Rudolf Oldeman, B. Kirby, André Rubbia, B. Paulos, D. Goeldi, C. E. Thorn, G. Varner, C. Ghag, J. Shahi, B. Kayser, C. Adams, S. H. Kettell, G. Brunetti, C. Densham, F. Noto, G. Mahler, M. Avila, J. Felde, P. Przewlocki, Matthew Mewes, D. Mcnulty, S. Adhikari, J. Osta, J. A. Nowak, R. M. Brown, Davide Sgalaberna, D. M. Asner, William Morse, Jan Conrad, G. P. Zeller, W. Sippach, C. D. Moore, D. Wahl, Nitish Dhingra, J. Willhite, T.V. Vieira, C. Taylor, W. E. Sondheim, Andrea Zani, J. Maricic, Anatoly Kopylov, Alec Habig, G. H. Collin, D. A. Dwyer, F. Mammoliti, J. K. Dejong, D. M. Lee, J. Park, L. Zang, L. Falk, N.V. Mokhov, C. E. Tull, K. Soustruznik, J. Howell, Xinhua Bai, X. Luo, Y. Karyotakis, K. Vaziri, D. Whittington, J. J. Back, C. Regenfus, Chao Zhang, H. Schellman, M. Fitton, A. Hahn, H. M. Steiner, N. S. Lockyer, H. R. Gallagher, M. Ross-Lonergan, B. P. Roe, L. S. Littenberg, Robert Wilson, C. S. Mishra, M. Rossella, M. Tripathi, S. Matsuno, A. Delbart, Xingguo Li, X. Bu, P. Vahle, G. A. Horton-Smith, A. Kostelecky, M. Hogan, S. Stoica, D. A. Harris, S. Murphy, Michael Thorpe, S. DiLuise, A. J. Finch, R. A. Johnson, G.L. Raselli, J. Huston, Stephen J. Parke, M. P. Decowski, D. Ioanisyan, S. Galymov, C. Mauger, L. Chaussard, P. Benetti, R. Sulej, S. Bertolucci, H. S. Budd, Rex Tayloe, F. Cavanna, N. J. Buchanan, X. Tian, Paolo Calafiura, A. Zalewska, G. B. Mills, Z. Parsa, B. Bleakley, Federico Sanchez, T. Vrba, H. Mendez, H. G. Berns, Lokesh Kumar, P. Mehta, M. Graham, Antonio Palazzo, F. Boffelli, S. Grullon, B. R. Littlejohn, I. Tropin, Michele Cascella, T. Viant, P. Ballett, N. Walsh, N. McConkey, S. J. Patton, E. Church, Michael Mooney, F.R. Torres, D. Cline, R. Imlay, I. Rakhno, T. Kobilarcik, Rukmani Mohanta, E.D. Zimmerman, E. Guardincerri, C. Vilela, M. Vagins, T. Wang, J. M. Yu, Animesh Chatterjee, G. Brown, E. Gramelini, Andre Petukhov, S. Magill, M. Groh, Martin Auger, L. Mualem, Artur M. Ankowski, J. Zalesak, J. G. Learned, E. Segreto, F. Jediny, Sarah Mancina, Niki Saoulidou, D. E. Jaffe, D. Edmunds, John Evans, E. Tatar, Utku Kose, Daniel A. Dale, David Martinez, John Ramsey, J. Urheim, Akhil Jhingan, W. Metcalf, Z. Djurcic, E. Mazzucato, K. Aryal, Maury Goodman, N. J. C. Spooner, O. V. Mineev, M. Bishai, R. Gandhi, James Stewart, S. R. Seibert, Joshua J. Turner, Parminder Kaur, J. Schwehr, D. Montanari, A. Rappoldi, T. Wachala, J. S. Díaz, Keith Rielage, J. Martín-Albo, J.J. Gómez-Cadenas, E.L. Snider, B. Russell, K. Grzelak, M. A. Leiguideoliveira, Amir Farbin, V. Paolone, J. Schneps, C. K. Jung, K. Yarritu, A. Higuera, Y. T. Tsai, Yang Li, R. Zwaska, Z. Vallari, Simon Lin, Pedro Cunha de Holanda, D. Karasavvas, Eric Endress, S. Hays, Paul Wilson, M. Luethi, E. Calligarich, Kuan Ken Lee, K. Chen, Sandip Pakvasa, K. Wood, N. Poudyal, L. F. Thompson, Asher Kaboth, L. Sexton-Kennedy, S. Lockwitz, G. Sinev, S. Hans, R. Musser, B. Bugg, Paola Sala, L. Bartoszek, S. Golapinni, B. Bhuyan, P. Hurh, W. H. Miller, O.B. Rodrigues, C. Bromberg, Brajesh C Choudhary, M. A. Thomson, R. Carr, J. Libo, M. Diamantopoulou, J. Bian, Yasaman Farzan, R. Roser, J. G. Boissevain, Caroline Morris, A. Gendotti, A. Himmel, J. Cranshaw, M. Zito, Bo Yu, S. Pordes, Thorsten Lux, I. M. Anghel, C. M. Castromonte, P. deJong, N. Solomey, R. Shrock, S. Bordoni, W. Fox, J. M. LoSecco, M. Khandaker, T. Kafka, M. H. Shaevitz, N. Barros, C. Booth, M. Rosen, Silvia Pascoli, M. Soderberg, Subhasmita Mishra, R. A. Gomes, Serhan Tufanli, B. Bhandari, D. Gibin, M. Stancari, F. Sergiampietri, Hye Young Lee, Gavin Davies, Michael DuVernois, V. Bocean, J. A. Musser, E. Pennacchio, Z. J. Liptak, K. Nikolics, R. J. Nichol, E. Kearns, P. Snopok, M. Sorel, Rohit Sharma, Sau Lan Wu, K. V. Tsang, Kaushik De, Timothyblake Watson, Y. Uchida, C. Mossey, R.A. Rameika, R. Svoboda, Gus Sinnis, Veljko Radeka, Y. Meng, E. Guarnaccia, Rebecca Bernstein, W. C. Louis, D. Navas, T. Blackburn, M. D. Haigh, Sandhya Choubey, A. Mefodiev, K. M. Heeger, R. Acciarri, Siqi Yang, Tomoko Ariga, Karol Lang, D. Cherdack, S.C. Timm, Milos Lokajicek, Minfang Yeh, Stephen T. Dye, G. Zavala, J. C. Thomas, M. Gold, C. McGrew, G. Vasseur, M. Thiesse, G. Diazbautista, K. Iwamoto, A. M. Szelc, Gareth J. Barker, I. Stancu, I. Shyrma, C. Andreopoulos, P. Shanahan, A. Bercellie, R. Corey, G.V. Velev, E. Catano-Mur, J. Fowler, S. J. M. Peeters, José W. F. Valle, B. Howard, Thomas Strauss, P. Lebrun, A. Radovic, A. Weinstein, Ara Ioannisian, H. T. Rakotondramanana, A. Curioni, R. W. Kadel, M. Borysova, Kate Scholberg, T. Ovsjannikova, S. Kemboi, J. Navarro, L. Periale, I. Kreslo, V. A. Kudryavtsev, D. R. Tiedt, G. Kumar, A. White, T. Handler, M. Worcester, A. Aranda-Fernandez, L. Rakotondravohitra, A. C. Weber, O. Prokofiev, J. Marteau, Max Robinson, C. Cantini, D. Pushka, N. Grant, H. Sobel, L. Favilli, J. Hewes, Srubabati Goswami, S.U. Shankar, D. Cronin-Hennessy, B. Baller, B. R. Behera, M. H. Kirby, T. Alion, D. Brailsford, S. Striganov, Laura Paulucci, C. D. Christofferson, B. Morgan, Y. Sun, A. Remoto, A. Hatzikoutelis, J. A. B. Coelho, A. Marchionni, P. Cole, Yuri Kamyshkov, Julián Félix, F. Varanini, John Marshall, R. Sharma, T. Hill, A. M. Gago, J. Heise, Lindley Winslow, R. Hatcher, G. Christodoulou, T. Davenne, Angela Fava, C. W. James, J. Joshi, S. Centro, H. Merritt, Paul Keener, Karol Hennessy, S. Söldner-Rembold, G. Santucci, C. S. Lin, E. T. Worcester, Michael Kramer, and J. Stock
Subjects: Nuclear physics, Physics, Conceptual design, Neutrino detector, 010308 nuclear & particles physics, 0103 physical sciences, Deep Underground Neutrino Experiment, Neutrino, 010306 general physics, Baseline (configuration management), 01 natural sciences
Published: 2016
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6. A systems biology model of oxidative stress that distinguishes adaptive and adverse cellular responses

Author: Narasimha Mandyam Krishnakumar, G. Jain, Sonali Das, S. Glavin, Stuart L. Cooper, Paul L. Carmichael, Andrew J. P. White, A. Middleton, J. Vethamanickam, Kalyanasundaram Subramanian, A. Raghavan, and N. Rajeshwara
Subjects: Systems biology, medicine, General Medicine, Computational biology, Biology, Toxicology, medicine.disease_cause, Oxidative stress, Cell biology
Published: 2015
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7. Characterisation of skin penetration pathways using stimulated Raman scattering microscopy.

Author: Goel A, Pendlington R, Glavin S, Chen T, and Belsey NA
Subjects: Humans, Nonlinear Optical Microscopy methods, Administration, Cutaneous, Drug Delivery Systems methods, Spectrum Analysis, Raman methods, Skin Absorption physiology, Skin metabolism, Hydrophobic and Hydrophilic Interactions
Abstract: Understanding the mechanisms governing the penetration of substances into the skin is crucial for the development of safe and effective topical drug delivery systems and skincare products. This study examined the partitioning of model permeants into human skin, by assessing six substances with diverse logP values. We employed stimulated Raman scattering (SRS) microscopy, an ambient, label-free optical imaging technique known for its ability to provide chemical distribution with subcellular resolution. Our investigation assessed partitioning into the two primary pathways through which substances traverse the skin: the intercellular lipid matrix and the intracellular route via corneocyte cells. We observed that the partitioning behaviour was strongly influenced by the lipophilicity of the molecule, with lipophilic compounds showing greater affinity for intercellular matrix with increased lipophilicity. Conversely, hydrophilic molecules demonstrated a preference for corneocyte cells, with their affinity increasing with increased hydrophilicity. The findings contribute to our understanding of the mechanisms underlying topical delivery and offer important implications and new methods beneficial for the development of safe and effective topical products. In addition, the methods presented could be valuable to reveal changes in drug partitioning or to assess targeting approaches in diseased skin models., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)
Published: 2024
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8. Measurement of chemical penetration in skin using Stimulated Raman scattering microscopy and multivariate curve resolution - alternating least squares.

Author: Goel A, Tsikritsis D, Belsey NA, Pendlington R, Glavin S, and Chen T
Subjects: Humans, Multivariate Analysis, Least-Squares Analysis, Spectrum Analysis, Raman methods, Nonlinear Optical Microscopy methods, Skin
Abstract: The mechanistic understanding of skin penetration underpins the design, efficacy and risk assessment of many high-value products including functional personal care products, topical and transdermal drugs. Stimulated Raman scattering (SRS) microscopy, a label free chemical imaging tool, combines molecular spectroscopy with submicron spatial information to map the distribution of chemicals as they penetrate the skin. However, the quantification of penetration is hampered by significant interference from Raman signals of skin constituents. This study reports a method for disentangling exogeneous contributions and measuring their permeation profile through human skin combining SRS measurements with chemometrics. We investigated the spectral decomposition capability of multivariate curve resolution - alternating least squares (MCR-ALS) using hyperspectral SRS images of skin dosed with 4-cyanophenol. By performing MCR-ALS on the fingerprint region spectral data, the distribution of 4-cyanophenol in skin was estimated in an attempt to quantify the amount permeated at different depths. The reconstructed distribution was compared with the experimental mapping of CN, a strong vibrational peak in 4-cyanophenol where the skin is spectroscopically silent. The similarity between MCR-ALS resolved and experimental distribution in skin dosed for 4 h was 0.79 which improved to 0.91 for skin dosed for 1 h. The correlation was observed to be lower for deeper layers of skin where SRS signal intensity is low which is an indication of low sensitivity of SRS. This work is the first demonstration, to the best of our knowledge, of combining SRS imaging technique with spectral unmixing methods for direct observation and mapping of the chemical penetration and distribution in biological tissues., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.)
Published: 2023
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9. In Silico Simulation of Simultaneous Percutaneous Absorption and Xenobiotic Metabolism: Model Development and a Case Study on Aromatic Amines.

Author: Coleman L, Lian G, Glavin S, Sorrell I, and Chen T
Subjects: Administration, Cutaneous, Amines administration & dosage, Biological Availability, Diffusion, Humans, Xenobiotics administration & dosage, Amines pharmacokinetics, Computer Simulation, Models, Biological, Skin metabolism, Skin Absorption, Xenobiotics pharmacokinetics
Abstract: Purpose: To advance physiologically-based pharmacokinetic modelling of xenobiotic metabolism by integrating metabolic kinetics with percutaneous absorption., Method: Kinetic rate equations were proposed to describe the metabolism of a network of reaction pathways following topical exposure and incorporated into the diffusion-partition equations of both xenobiotics and metabolites. The published ex vivo case study of aromatic amines was simulated. Diffusion and partition properties of xenobiotics and subsequent metabolites were determined using physiologically-based quantitative structure property relationships. Kinetic parameters of metabolic reactions were best fitted from published experimental data., Results: For aromatic amines, the integrated transdermal permeation and metabolism model produced data closely matched by experimental results following limited parameter fitting of metabolism rate constants and vehicle:water partition coefficients. The simulation was able to produce dynamic concentration data for all the dermal layers, as well as the vehicle and receptor fluid., Conclusion: This mechanistic model advances the dermal in silico functionality. It provides improved quantitative spatial and temporal insight into exposure of xenobiotics, enabling the isolation of governing features of skin. It contributes to accurate modelling of concentrations of xenobiotics reaching systemic circulation and additional metabolite concentrations. This is vital for development of both pharmaceuticals and cosmetics.
Published: 2020
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10. First Measurement of the Total Neutron Cross Section on Argon between 100 and 800 MeV.

Author: Bhandari B, Bian J, Bilton K, Callahan C, Chaves J, Chen H, Cline D, Cooper RL, Danielson D, Danielson J, Dokania N, Elliott S, Fernandes S, Gardiner S, Garvey G, Gehman V, Giuliani F, Glavin S, Gold M, Grant C, Guardincerri E, Haines T, Higuera A, Ji JY, Kadel R, Kamp N, Karlin A, Ketchum W, Koerner LW, Lee D, Lee K, Liu Q, Locke S, Louis WC, Manalaysay A, Maricic J, Martin E, Martinez MJ, Martynenko S, Mauger C, McGrew C, Medina J, Medina PJ, Mills A, Mills G, Mirabal-Martinez J, Olivier A, Pantic E, Philipbar B, Pitcher C, Radeka V, Ramsey J, Rielage K, Rosen M, Sanchez AR, Shin J, Sinnis G, Smy M, Sondheim W, Stancu I, Sterbenz C, Sun Y, Svoboda R, Taylor C, Teymourian A, Thorn C, Tull CE, Tzanov M, Van de Water RG, Walker D, Walsh N, Wang H, Wang Y, Yanagisawa C, Yarritu A, and Yoo J
Abstract: We report the first measurement of the neutron cross section on argon in the energy range of 100-800 MeV. The measurement was obtained with a 4.3-h exposure of the Mini-CAPTAIN detector to the WNR/LANSCE beam at LANL. The total cross section is measured from the attenuation coefficient of the neutron flux as it traverses the liquid argon volume. A set of 2631 candidate interactions is divided in bins of the neutron kinetic energy calculated from time-of-flight measurements. These interactions are reconstructed with custom-made algorithms specifically designed for the data in a time projection chamber the size of the Mini-CAPTAIN detector. The energy averaged cross section is 0.91±0.10(stat)±0.09(syst) b. A comparison of the measured cross section is made to the GEANT4 and FLUKA event generator packages, where the energy averaged cross sections in this range are 0.60 and 0.68 b, respectively.
Published: 2019
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11. Development of a Two-Dimensional Model for Predicting Transdermal Permeation with the Follicular Pathway: Demonstration with a Caffeine Study.

Author: Kattou P, Lian G, Glavin S, Sorrell I, and Chen T
Subjects: Administration, Cutaneous, Biological Availability, Caffeine administration & dosage, Caffeine pharmacology, Caffeine toxicity, Computer Simulation, Dermis chemistry, Diffusion, Drug Delivery Systems, Drug Liberation, Epidermis chemistry, Hair metabolism, Hair Follicle chemistry, Humans, Lipids chemistry, Permeability, Sebum metabolism, Skin Absorption, Solutions, Caffeine chemistry, Hair chemistry, Sebum chemistry
Abstract: Purpose: The development of a new two-dimensional (2D) model to predict follicular permeation, with integration into a recently reported multi-scale model of transdermal permeation is presented., Methods: The follicular pathway is modelled by diffusion in sebum. The mass transfer and partition properties of solutes in lipid, corneocytes, viable dermis, dermis and systemic circulation are calculated as reported previously [Pharm Res 33 (2016) 1602]. The mass transfer and partition properties in sebum are collected from existing literature. None of the model input parameters was fit to the clinical data with which the model prediction is compared., Results: The integrated model has been applied to predict the published clinical data of transdermal permeation of caffeine. The relative importance of the follicular pathway is analysed. Good agreement of the model prediction with the clinical data has been obtained. The simulation confirms that for caffeine the follicular route is important; the maximum bioavailable concentration of caffeine in systemic circulation with open hair follicles is predicted to be 20% higher than that when hair follicles are blocked., Conclusions: The follicular pathway contributes to not only short time fast penetration, but also the overall systemic bioavailability. With such in silico model, useful information can be obtained for caffeine disposition and localised delivery in lipid, corneocytes, viable dermis, dermis and the hair follicle. Such detailed information is difficult to obtain experimentally.
Published: 2017
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11 results on '"S. Glavin"'

1. The Mini-CAPTAIN liquid argon time projection chamber

2. First Measurement of the Total Neutron Cross Section on Argon between 100 and 800 MeV

3. Design and performance of a 35-ton liquid argon time projection chamber as a prototype for future very large detectors

4. The DUNE Far Detector Interim Design Report Volume 1: Physics, Technology and Strategies

5. Long-Baseline Neutrino Facility (LBNF) and Deep Underground Neutrino Experiment (DUNE): Conceptual Design Report. Volume 4: The DUNE Detectors at LBNF

6. A systems biology model of oxidative stress that distinguishes adaptive and adverse cellular responses

7. Characterisation of skin penetration pathways using stimulated Raman scattering microscopy.

8. Measurement of chemical penetration in skin using Stimulated Raman scattering microscopy and multivariate curve resolution - alternating least squares.

9. In Silico Simulation of Simultaneous Percutaneous Absorption and Xenobiotic Metabolism: Model Development and a Case Study on Aromatic Amines.

10. First Measurement of the Total Neutron Cross Section on Argon between 100 and 800 MeV.

11. Development of a Two-Dimensional Model for Predicting Transdermal Permeation with the Follicular Pathway: Demonstration with a Caffeine Study.

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11 results on '"S. Glavin"'

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