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ABSTRACT Objective: Verify the influence of different break times between sprints on the performance of amateur futsal athletes. Methods: 10 individuals, men, amateur futsal athletes (Age: 21.5 ± 1.6; Weight: 72.4 ± 6.88; Height: 1.72 ± 0.05; BMI: 24.3 ± 1.2; Fat%: 13.7 ± 3.3, VO2peak: 49.1 ± 10.5) participated in the study. Individuals were randomly selected to perform sessions with sprints (10 sets 20 m) with different pause times of 15 (S15), 30 (S30) and 60 (S60) seconds. For performance analysis, the speed (km / h) applied to each sprint was used and monitored by a device with a photocell (CEFISE Biotecnologia Esportiva®). Results: There was an interaction between speed and interval time (p = 0.000). For condition S15, a greater reduction in performance was observed (p ≤ 0.05), while for S30 and S60, no significant reduction in performance was observed (p > 0.05). The data for the area under the curve showed a significant difference (p = 0.000), where the interval of 60 s (S60) was longer compared to the values of 30 (S30) (p = 0.000) and 15 s (S15) (p = 0.000). However, there were no significant differences between the 30 and 15 s data (p = 0.248). Conclusion: A shorter time (15 s) interval between repeated sprints can significantly affect performance compared to longer breaks (30 and 60 s), but all the conditions tested here can be positive for the improvement of performance, mainly in sports that demand fast and efficient motor actions such as futsal.

Abstract The influence of repeated lockdowns on mental health and social isolation is unknown. We conducted a longitudinal study of the influence of repeated mild lockdowns during two emergency declarations in Japan, in May 2020 and February 2021. The analyses included 7893 people who participated in all online surveys. During repeated mild lockdowns, mental and physical symptoms decreased overall, while loneliness increased and social networks decreased. Subgroup analyses revealed that depression and suicidal ideation did not decrease only in the younger age group (aged 18–29 years) and that younger and middle-aged people (aged 18–49 years), women, people with a history of treatment for mental illness, and people who were socially disadvantaged in terms of income had higher levels of mental and physical symptoms at all survey times. Additionally, comprehensive extraction of the interaction structure between depression, demographic attributes, and psychosocial variables indicated that loneliness and social networks were most closely associated with depression. These results indicate that repeated lockdowns have cumulative negative effects on social isolation and loneliness and that susceptible populations, such as young people and those with high levels of loneliness, require special consideration during repeated lockdown situations.

This study evaluates the rainwater harvesting system to determine the chemical quality of the water and allocate it for use. Samples were collected in the city of Rio de Janeiro at the points of Direct Precipitation (DP), First Flush (FF) and Reservoir (RR). The methodology involved carrying out an analysis of Ca, Cd, Cu, Na, Ni, Fe, K, Mg, Pb, Zn, conductivity, turbidity, pH and chloride. The R language was used for the principal component analysis, Pearson coefficient correlation, hierarchical cluster analysis, Tukey test and boxplot. The results show that when there is no interference from the catchment surface (DP), the rainwater has a low concentration of metals, although the first millimeters of rain have a concentration above what is permissible in the guidelines issued by the Ministry of Health (Ordinance n° 05/2017). The disposal system (FF) reduced the concentration of pollutants in the RR, but not enough to comply with legislation. It was noted that Ca, K and Na are the main metals found in rainwater. During the dry period, there were significant correlations between the physico-chemical and meteorological parameters. The high concentration of metals in the wet period suggests that rain assists the cleaning of the atmosphere and that most metals are present in the form of aerosols or fine particles suspended in the air. The findings reveal significant indications of acid rain and pre-treatment is recommended to ensure rainwater can be used safely for more mundane purposes.

Promoting exercise regimens that aim at enhancing the quality of individuals’ subjective exercise experience can be challenging. Given the recent theoretical contributions regarding the possible interaction of exercise intensity-traits and several motivational variables, as well as their potential value for exercise adherence, the objective of this study was to examine the mediation role of basic psychological needs in the relationship between preference for and tolerance of exercise intensity and enjoyment. This cross-sectional study comprised a total of 160 exercisers (Mage = 34.12, SD = 9.23, 73 males) enrolled in several health clubs. All analyses were performed using SPSS v. 23.0/PROCESS v. 3.4. The results indicate that intensity-traits presented positive associations with enjoyment, and negative associations with all of needs frustration variables. A mediation role of needs frustration emerged in the intensity-traits and enjoyment associations that was analyzed according to relatable theoretical considerations.

Background: Chronic graft-versus-host disease (cGvHD) is a major complication after allogeneic hematopoietic cell transplantation. Extracorporeal photopheresis (ECP) is an immunotherapy treatment for cGvHD, although suitable response biomarkers are lacking. Materials & methods: We analyzed data from six cGvHD patients undergoing ECP at a reference center from 826 to 2866 days. Circulating Tregs were enumerated, patient’s clinical evolution, immunosuppression dose and adverse events (AEs) registered. Results: We observed an increase in Tregs, a decrease in immunosuppression dosage and symptoms improvement. Mild AEs occurred at a very low rate. Conclusion: In these patients, the improvement of cGvHD, with low AEs, confirms a place for ECP as treatment. Improvements were accompanied by an increase in circulating Tregs, suggesting their role as a biomarker.

The aim of this review is to demonstrate the effects of cardiovascular interval training (IT) on healthy elderly subjects. We used the recommendations of the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. The following variables were observed: resting heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MBP), heart rate variability (HRV), baroreflex activity (BA), and maximal oxygen uptake (VO2max). Studies were searched for in the MedLine, PubMed, and Sport Discus databases considering publications between 1990 and 2019. To find the studies, the keywords used were “Interval and Elderly Training” or “Interval Training and Baroreflex Sensing” or “Interval Training and Aging and Pressure Arterial and Blood Pressure Training” or “Interval Training and Variation in Aging and Heart Rate” or “Interval Training and Sensitivity to the Elderly and Baroreflex” or “Interval Training and Variability in the Elderly and Heart Rate.” The systematic search identified 1,140 hits. The analysis of the study was performed through a critical review of the content. One thousand one hundred forty articles were identified. Of these, 1,108 articles were excluded by checking the articles and abstracts. Finally, 32 studies were selected for full reading while 26 studies were eliminated because they did not contain a methodology according to the purpose of this review. Thus, six studies were included for the final analysis. The PEDro score was used for analyzing the study quality and found 4,8 ± 1,3 points (range: 3–6). Positive results were found with the different IT protocols in the observed variables. Results show that IT protocols can be an efficient method for functional improvement of cardiovascular and cardiorespiratory variables in the healthy elderly, especially HR, SBP, DBP, MAP, HRV, BA, and VO2max. However, this method can be included in the prescription of aerobic training for the elderly to obtain conditional improvements in the cardiovascular system, thus being an important clinical intervention for the public.

The main of the present study was to identify the heart rate threshold based on heart rate kinetics during graded maximal exercise in football players. Twenty-six male football players performed a maximal exercise test (Bruce protocol) on a motor-driven treadmill. Oxygen uptake (VO2) and heart rate (HR) were monitored, recorded and resampled at 3.5Hz. The ventilatory threshold (VT), and respiratory compensation (RC), heart rate deflection points (HRDP1 and HRDP2) and heart rate kinetics threshold (HRT) were determined by computerized methods. The heart rate variability (HRV) was assessed in the frequency domain. The HRT averaged 89.9 ± 1.2 % of the VO2 peak. The HRT showed poor correlations and significant differences compared with HRDP1 (r = 0.46) and VT (r = 0.51), but was not different from, and highly correlated with, HRDP2 (0.98) and RC (0.90). Bland Altman plots showed all athletes into 95% of limits of agreement, and intraclass correlation coefficient showed good agreements between points obtained from HRT compared with HRDP2 (0.96) and RC (0.98). The HRT was highly correlated with HRDP2 and RC, suggesting it could be a marker for cardiorespiratory fatigue.

Obesity is a disease characterized by an excessive accumulation of fat in the body and it has been linked the enhancement of inflammation-related endogenous molecules, such as adenosine (AD). Since blueberries may induce anti-obesity effects, we tested the hypothesis that blueberries consumption contained in hypocaloric diet would decrease weight, BMI as well as glucose, cholesterol, triglycerides and AD levels in obese subjects. The baseline conditions of obesity-related variables were collected for all subjects prior the implementation of blueberries intake. Later, participants received a hypocaloric diet that included the consumption of blueberries (50 g/day) during 30 days. We found that male obese subjects that consumed blueberries showed a decrease in weight, glucose, cholesterol, triglycerides and AD whereas female obese subjects that ate blueberries in hypocaloric diet showed no differences in weight, BMI, glucose and triglycerides but displayed a diminution in cholesterol and AD levels. Data suggest that intake of blueberries seems to decrease some of the obese-linked parameters in male or female subjects. Importantly, blueberry consumption decreased the inflammation-related compound AD in both sexes.

Histone methylation/demethylation plays an important modulatory role in chromatin restructuring, RNA transcription and is essential for controlling a plethora of biological processes. Due to many human diseases have been related to histone methylation/demethylation, several compounds such as 3-deazaneplanocin A (DZNep) or 3-((6-(4,5-Dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoic acid; N-[2-(2-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-Alanine (GSK-J1), have been designed to inhibit histone methylase or suppress histone demethylase, respectively. In the present study, we investigated the effects on the sleep-wake cycle and sleep-related neurochemical levels after systemic injections of DZNep or GSK-J1 given during the light or dark phase in rats. DZNep dose-dependently (0.1, 1.0, or 10 mg/kg, i.p.) prolonged wakefulness (W) duration while decreased slow wave sleep (SWS) and rapid eye movement sleep (REMS) time spent during the lights-on period with no changes observed in dark phase. In opposite direction, GSK-J1 (0.1, 1.0, or 10 mg/kg, i.p.) injected at the beginning of the lights-on period induced no statistical changes in W, SWS, or REMS whereas if administered at darkness, we found a diminution in W and an enhancement in SWS and REMS. Finally, brain microdialysis experiments in freely moving animals were used to evaluate the effects of DZNep or GSK-J1 treatments on contents of sleep-related neurochemicals. The results showed that DZNep boosted extracellular levels of dopamine, norepinephrine, epinephrine, serotonin, adenosine, and acetylcholine if injected at the beginning of the lights-on period whereas GSK-J1 exerted similar outcomes but when administered at darkness. In summary, DZNep and GSK-J1 may control the sleep-wake cycle and sleep-related neurochemicals through histone methylation/demethylation activity.

There is preliminary evidence suggesting that hippocampal functioning is associated with attachment style. However, it is unknown if attachment is also associated with hippocampal-related cognitive function such as spatial learning and recall. This study aims to verify if attachment dimensions are associated with spatial learning and recall. Sixty-five female participants were recruited and were evaluated using the Adult Attachment Scale-R and tested on a virtual maze navigation task (VMT) at one moment (exploratory trial + 3 trials) and 24 h later (3 trials). There was a significant Moment × Trial × Close-Depend interaction for the outcome time, F(2,126) = 3.807, p = 0.025, with post hoc analysis indicating that the High Close-Depend group displayed significant improvements between Trial 1 and Trial 3 in the post-test assessment. Conversely, the Low Close-Depend group displayed significant improvements between Trial 1and Trial 3 but on the pre-test assessment. Furthermore, the Low Close-Depend group presented significant better performance in pre-test Trial 3 in comparison to the High Close-Depend group. Thereby, it seems that low comfort with proximity and trust in others is associated with reduced spatial recall, although spatial learning performance was actually superior in these participants. It is possible that reduced exposure to social interaction and meaningful relationships may be reduced in the Low Close-Depend group, leading to modifications in hippocampal function and, ultimately, reduced spatial recall. Oppositely, participants in the High Close-Depend group may not display typical spatial learning in the proposed task as they are more willing to freely explore the presented environment.

Young athletes are considered the healthiest group in society. Although rare, there are still reports of sudden death or cardiac arrest on the playing fields. Clinical evaluation is of paramount importance for the identification of possible pathological states that confer increased risk of these events. Interpretation of the electrocardiogram of young athletes can help identify changes associated with heart disease that might preclude the participation in sports. In this context, it is essential to recognize the electrocardiographic patterns that represent the structural and electrical remodeling resulting from continued adaptation to exercise, and which thus do not increase the risk of adverse events during exercise. The European Society of Cardiology (ESC) and the American Heart Association (AHA) have issued consensus documents summarizing which electrocardiographic abnormalities should be considered ‘physiological’, resulting from adaptation to exercise (‘athlete's heart’), and which should be considered pathological and thus require further study. However, the two societies have different approaches with respect to the electrocardiographic screening of athletes. This paper provides a brief review of current evidence regarding the electrocardiographic findings considered normal and abnormal in athletes, and presents the arguments of the ESC and AHA for electrocardiographic screening in this population. Resumo: Os jovens atletas são considerados como o grupo mais saudável da sociedade. Apesar de raros, surgem ainda relatos de morte súbita ou paragem cardiorrespiratória nos campos de jogo. A avaliação clínica reveste-se de primordial importância para a identificação de eventuais estados patológicos que confiram risco acrescido destes eventos. A interpretação do eletrocardiograma destes jovens atletas pode permitir identificar alterações associadas a patologia cardíaca que condicione ou não a prática do exercício físico. Neste contexto, torna-se essencial reconhecer os padrões eletrocardiográficos que representam a remodelagem estrutural e elétrica resultantes da adaptação ao exercício continuado, e que por sua vez não acarretam risco acrescido de eventos adversos durante a prática de exercício. As Sociedades Europeia e Americana de Cardiologia emitiram documentos de consenso que procuram resumir quais as alterações eletrocardiográficas consideradas como «fisiológicas» e resultantes da adaptação ao exercício (coração de atleta) e quais as alterações consideradas como patológicas e que portanto implicam o estudo subsequente dos casos em que são identificadas. Estas sociedades apresentam, no entanto uma abordagem diferente no que se refere ao rastreio eletrocardiográfico de atletas. Este artigo fornece uma breve revisão da evidência atual referente aos achados eletrocardiográficos considerados como normais e anormais em atletas, assim como apresenta as argumentações das Sociedades Europeia e Americana de Cardiologia referentes ao rastreio eletrocardiográfico nesta população. Keywords: Athlete's heart, Electrocardiographic screening, Sudden death, Palavras-chave: Coração de atleta, Rastreio de ECG, Morte súbita

An increasing body of experimental data have suggested that aberrant functional interactions between large-scale networks may be the most plausible explanation of psychopathology across multiple mental disorders, including substance-related and addictive disorders. In the current research, we have investigated the association between problematic cannabis use (PCU) and triple-network electroencephalographic (EEG) functional connectivity. Twelve participants with PCU and 24 non-PCU participants were included in the study. EEG recordings were performed during resting state (RS). The exact Low-Resolution Electromagnetic Tomography software (eLORETA) was used for all EEG analyses. Compared to non-PCU, PCU participants showed an increased delta connectivity between the salience network (SN) and central executive network (CEN), specifically, between the dorsal anterior cingulate cortex and right posterior parietal cortex. The strength of delta connectivity between the SN and CEN was positively and significantly correlated with higher problematic patterns of cannabis use after controlling for age, sex, educational level, tobacco use, problematic alcohol use, and general psychopathology (rp = 0.40, p = 0.030). Taken together, our results show that individuals with PCU could be characterized by a specific dysfunctional interaction between the SN and CEN during RS, which might reflect the neurophysiological underpinnings of attentional and emotional processes of cannabis-related thoughts, memories, and craving.

This study examined the motivational determinants of athletes perceived effort in football considering the four-stage motivational sequence at the contextual level proposed by Hierarchical Model of Intrinsic and Extrinsic Motivation: task-involving climate, basic psychological needs, self-determined motivation (SDM), and perceived effort. Additionally, SEM multi-group analysis across different age-groups (U15, U17, U19, and U21 years) and serial mediation of basic psychological needs (BPNs) and SDM on the task-involving motivational climate and the perceived effort were also analyzed. Two independent samples of male football athletes (N = 403, N = 403), aged 13–20 years were enrolled in this study. The results support the adequacy of the structural model in explaining the perceived effort of football atheltes in all samples under analysis, and was invariant across U17, U19, and U21. However, it was not invariant across U15 and U17, U19 and U21. Furthermore, results from the serial mediation showed significant indirect effects in all samples, supporting self-determination theoretical assumptions, reinforcing the importance of BPNs satisfaction and behavioral regulation in the relation in analysis. The results show that when coaches promote a task-involving climate, the BPNs satisfaction of athletes improves. This climate will facilitate the regulation of their behaviors toward more autonomous forms of motivation, with positive outcomes in the athletes perceived effort.

DOI: 10.12957/sustinere.2014.14126A “Síndrome do Edifício Doente” é um termo utilizado para definir a má qualidade do ar de ambientes interiores e tem sido de preocupação crescente da comunidade científica. A avaliação da qualidade do ar, nos locais amostrados no HUPE, fundamentada na resolução n° 9 de 2003 da Agência Nacional de Vigilância Sanitária, teve como objetivos conhecer e informar para que a Comissão de Controle de Infecção Hospitalar avalie a interação deste fator com as infecções nosocomiais e decida pela necessidade, ou não, de medidas corretivas e contribuir para o conhecimento e desenvolvimento de técnicas e controle da poluição “Indoor”. As amostras foram coletadas com um amostrador de ar tipo impactador linear, de um estágio (MERCK) e a interpretação dos resultados utilizou dois critérios contidos na norma vigente: o valor máximo aceitável (VMA) de fungos em ambientes internos (750UFC/m3) e o limite aceitável entre a contaminação interna e externa (I/E ≤ 1,5). Entre os sessenta ambientes avaliados nos três primeiros pavimentos do HUPE 20% do total encontravam-se em desacordo com relação ao número de UFC/m3 e 16,6% em relação à relação I/E. Conclui-se que 28% dos setores avaliados do 1° pavimento do HUPE e 26% dos contidos no 2° pavimento não estão tendo a renovação de ar desejada, propiciando o acúmulo de fungos.

Background: Interpretation of the symptoms of acute coronary syndrome (ACS) can influence the time of hospital admission and negatively affect patients’ prognosis. We decided to explore illness perception and its predictors among patients with ACS. Methods: We conducted a retrospective analysis of all consecutive patients with ACS admitted to the cardiology department of a tertiary hospital between January and September 2011. Data were obtained from patients’ medical records and telephone interviews. Results: One hundred and eighty-six patients with ACS (mean age 64±12 years; 70% male) were included. The majority (62.6%) had no perception of ACS until informed by their doctor. Only 26% of patients with ST-segment elevation myocardial infarction had perception of cardiac disease. Among those who had perception, 82.6% were men and 58% had a previous diagnosis of ischemic heart disease (IHD). Gender and previous diagnosis of IHD were independent predictors of ACS perception, with male gender and patients with previous IHD having greater illness perception. No association was found between ACS perception and age or residence area (rural vs. urban). Conclusions: The illness perception of ACS patients needs to be improved, independently of sociodemographic factors. An educational program for the general population, but particularly for women and individuals without a past history of IHD, focusing on the alert signs for ACS, may help to improve illness perception in this setting. Resumo: Introdução: A interpretação dos sintomas da síndrome coronária aguda (SCA) pode influenciar o tempo da admissão hospitalar e afetar negativamente o prognóstico. Decidimos explorar a perceção da doença e os seus preditores em doentes com SCA. Métodos: Efetuamos uma análise retrospetiva de todos os doentes consecutivamente admitidos no departamento de cardiologia de um hospital terciário com SCA, entre janeiro e setembro de 2011. A informação foi obtida através dos registos clínicos e entrevista telefónica. Resultados: Cento e oitenta e seis doentes (idade média de 64 ± 12 anos; 70% homens) com SCA foram incluídos. A maioria (62,6%) dos doentes não tinha perceção da SCA atéàinformação médica. Apenas 26% dos doentes com enfarte agudo do miocárdio com supradesnivelamento do segmento ST tiveram perceção da doença cardíaca. Entre aqueles que tiveram perceção, 82,6% eram homens e 58% tinha um diagnóstico prévio de doença cardíaca isquémica (DCI). O sexo e o diagnóstico prévio de DCI foram preditores independentes da perceção da SCA, tendo o sexo masculino e os doentes com DCI prévia uma perceção superior. Nenhuma associação foi encontrada relativamente à idade e área de residência (rural versus urbana). Conclusões: A perceção de doença dos pacientes com SCA precisa de ser melhorada, independentemente de fatores sociodemográficos. Um programa educacional que abranja a população geral, particularmente as mulheres e aqueles sem antecedentes de DCI, e que foque os sinais de alerta para a SCA poderá ser útil para melhorar a perceção dos sintomas neste contexto. Keywords: Acute coronary syndrome, Illness perception, Education, Palavras-chave: Síndroma coronária aguda, Perceção de doença, Educação

Introdução: O exercício físico intenso induz inflamação, processo que ocorre visando o reparo tecidual. Os leucócitos para sanar este dano produzem grande quantidade de espécies reativas de oxigênio e a oxidação de uma série de biomoléculas. Objetivo: O presente estudo teve por objetivo avaliar os efeitos do treinamento físico do curso básico paraquedista sobre os leucócitos circulantes, bem como se a suplementação com os nutrientes, selênio, e as vitaminas C e E, poderiam atenuar tais efeitos. Métodos: Foi realizado um estudo randomizado, experimental, duplo-cego e controlado por placebo, com 20 militares do sexo masculino (35 ± 10 anos), suplementados durante 37 dias, iniciando 18 dias antes do treinamento e divididos em dois grupos: Gp1 (n=11) que ingeriu cápsulas contendo selênio quelado (0,06 mg), vitamina C (1000 mg) e vitamina E (500 mg), e o Gp2 (n= 9) que ingeriu placebo (1500 mg de amido). Amostras de sangue foram obtidas em diferentes momentos: anterior ao estudo (T0 basal), 12 dias antes do treinamento (T1) e após 11 (T2) e 14 (T3) dias de treinamento. Os efeitos do exercício e dos suplementos, foram analisados pela ANOVA 4X2 e teste pós-hoc de Bonferroni com nível de significância de p

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