244 results on '"Rupprecht R"'
Search Results
2. Enhancing predictability of IDH mutation status in glioma patients at initial diagnosis: a comparative analysis of radiomics from MRI, [18F]FET PET, and TSPO PET
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Kaiser, Lena, Quach, S., Zounek, A. J., Wiestler, B., Zatcepin, A., Holzgreve, A., Bollenbacher, A., Bartos, L. M., Ruf, V. C., Böning, G., Thon, N., Herms, J., Riemenschneider, M. J., Stöcklein, S., Brendel, M., Rupprecht, R., Tonn, J. C., Bartenstein, P., von Baumgarten, L., Ziegler, S., and Albert, N. L.
- Published
- 2024
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3. Antidepressant effect of repetitive transcranial magnetic stimulation is not impaired by intake of lithium or antiepileptic drugs
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Hebel, T., Abdelnaim, M. A., Deppe, M., Kreuzer, P. M., Mohonko, A., Poeppl, T. B., Rupprecht, R., Langguth, B., and Schecklmann, M.
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- 2021
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4. Enhancing predictability of IDH mutation status in glioma patients at initial diagnosis: a comparative analysis of radiomics from MRI, [18F]FET PET, and TSPO PET.
- Author
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Kaiser, Lena, Quach, S., Zounek, A. J., Wiestler, B., Zatcepin, A., Holzgreve, A., Bollenbacher, A., Bartos, L. M., Ruf, V. C., Böning, G., Thon, N., Herms, J., Riemenschneider, M. J., Stöcklein, S., Brendel, M., Rupprecht, R., Tonn, J. C., Bartenstein, P., von Baumgarten, L., and Ziegler, S.
- Subjects
POSITRON emission tomography ,RADIOMICS ,CENTRAL nervous system tumors ,RECEIVER operating characteristic curves ,MAGNETIC resonance imaging ,FEATURE extraction - Abstract
Purpose: According to the World Health Organization classification for tumors of the central nervous system, mutation status of the isocitrate dehydrogenase (IDH) genes has become a major diagnostic discriminator for gliomas. Therefore, imaging-based prediction of IDH mutation status is of high interest for individual patient management. We compared and evaluated the diagnostic value of radiomics derived from dual positron emission tomography (PET) and magnetic resonance imaging (MRI) data to predict the IDH mutation status non-invasively. Methods: Eighty-seven glioma patients at initial diagnosis who underwent PET targeting the translocator protein (TSPO) using [
18 F]GE-180, dynamic amino acid PET using [18 F]FET, and T1-/T2-weighted MRI scans were examined. In addition to calculating tumor-to-background ratio (TBR) images for all modalities, parametric images quantifying dynamic [18 F]FET PET information were generated. Radiomic features were extracted from TBR and parametric images. The area under the receiver operating characteristic curve (AUC) was employed to assess the performance of logistic regression (LR) classifiers. To report robust estimates, nested cross-validation with five folds and 50 repeats was applied. Results: TBRGE-180 features extracted from TSPO-positive volumes had the highest predictive power among TBR images (AUC 0.88, with age as co-factor 0.94). Dynamic [18 F]FET PET reached a similarly high performance (0.94, with age 0.96). The highest LR coefficients in multimodal analyses included TBRGE-180 features, parameters from kinetic and early static [18 F]FET PET images, age, and the features from TBRT2 images such as the kurtosis (0.97). Conclusion: The findings suggest that incorporating TBRGE-180 features along with kinetic information from dynamic [18 F]FET PET, kurtosis from TBRT2 , and age can yield very high predictability of IDH mutation status, thus potentially improving early patient management. [ABSTRACT FROM AUTHOR]- Published
- 2024
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5. Darmflora und Depression: Pathophysiologie der Depression: Hypothalamus-Hypophysen-Nebennierenrinden- und Mikrobiota-Darm-Hirn-Achse
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Lima-Ojeda, J. M., Rupprecht, R., and Baghai, T. C.
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- 2020
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6. TSPO PET, tumour grading and molecular genetics in histologically verified glioma: a correlative 18F-GE-180 PET study
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Unterrainer, M., Fleischmann, D. F., Vettermann, F., Ruf, V., Kaiser, L., Nelwan, D., Lindner, S., Brendel, M., Wenter, V., Stöcklein, S., Herms, J., Milenkovic, V. M., Rupprecht, R., Tonn, J. C., Belka, C., Bartenstein, P., Niyazi, M., and Albert, N. L.
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- 2020
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7. Sleep after intranasal progesterone vs. zolpidem and placebo in postmenopausal women – A randomized, double-blind cross over study
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Schüssler, P., Kluge, M., Adamczyk, M., Beitinger, M.E., Beitinger, P., Bleifuss, A., Cordeiro, S., Mattern, C., Uhr, M., Wetter, T.C., Yassouridis, A., Rupprecht, R., Friess, E., and Steiger, A.
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- 2018
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8. Comparison of 18F-GE-180 and dynamic 18F-FET PET in high grade glioma: a double-tracer pilot study
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Unterrainer, Marcus, Fleischmann, D. F., Diekmann, C., Vomacka, L., Lindner, S., Vettermann, F., Brendel, M., Wenter, V., Ertl-Wagner, B., Herms, J., Wetzel, C., Rupprecht, R., Tonn, J. C., Belka, C., Bartenstein, P., Niyazi, M., and Albert, Nathalie L.
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- 2019
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9. Corticotropin-releasing hormone induces depression-like changes of sleep electroencephalogram in healthy women
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Schüssler, P., Kluge, M., Gamringer, W., Wetter, T.C., Yassouridis, A., Uhr, M., Rupprecht, R., and Steiger, A.
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- 2016
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10. Gerontopsychologische Diagnostik
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Rupprecht, R., Gunzelmann, Th., Oswald, W.D., and Maercker, Andreas, editor
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- 2015
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11. Darm und Gehirn
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Oertel, W. and Rupprecht, R.
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- 2020
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12. TSPO PET with [18F]GE-180 sensitively detects focal neuroinflammation in patients with relapsing–remitting multiple sclerosis
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Unterrainer, Marcus, Mahler, C., Vomacka, L., Lindner, S., Havla, J., Brendel, M., Böning, G., Ertl-Wagner, B., Kümpfel, T., Milenkovic, V. M., Rupprecht, R., Kerschensteiner, M., Bartenstein, P., and Albert, Nathalie L.
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- 2018
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13. Multimodale Radiomicsanalysen zur Prädiktion des IDH-Mutationsstatus bei erstdiagnostizierten Gliomen
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Kaiser, L., additional, Quach, S., additional, Zounek, A. J., additional, Zatcepin, A., additional, Holzgreve, A., additional, Bollenbacher, A., additional, Bartos, L., additional, Ruf, V., additional, Böning, G., additional, von Baumgarten, L., additional, Thon, N., additional, Herms, J., additional, Riemenschneider, M. J., additional, Stöcklein, S., additional, Brendel, M., additional, Rupprecht, R., additional, Tonn, J. C., additional, Bartenstein, P., additional, Ziegler, S., additional, and Albert, N. L., additional
- Published
- 2023
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14. TSPO PET for glioma imaging using the novel ligand 18F-GE-180: first results in patients with glioblastoma
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Albert, Nathalie L., Unterrainer, M., Fleischmann, D. F., Lindner, S., Vettermann, F., Brunegraf, A., Vomacka, L., Brendel, M., Wenter, V., Wetzel, C., Rupprecht, R., Tonn, J.-C., Belka, C., Bartenstein, P., and Niyazi, M.
- Published
- 2017
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15. Dickdarmmikrobiom und Depression: Die andere Seite unseres Selbst
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Manook, A., Hiergeist, A., Rupprecht, R., and Baghai, T. C.
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- 2016
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16. Das deutsche Forschungsnetz zu psychischen Erkrankungen
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Bauer, M., Banaschewski, T., Heinz, A., Kamp-Becker, I., Meyer-Lindenberg, A., Padberg, F., Rapp, M. A., Rupprecht, R., Schneider, F., Schulze, T. G., and Wittchen, H.‑U.
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- 2016
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17. Prediction of future falls in a community dwelling older adult population using instrumented balance and gait analysis
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Bauer, C.M., Gröger, I., Rupprecht, R., Marcar, V.L., and Gaßmann, K.G.
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- 2016
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18. Prognostische Wertigkeit der TSPO-PET bei Patienten mit Gliomrezidiv
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Quach, S., additional, Holzgreve, A., additional, Kaiser, L., additional, Dekorsy, F.J., additional, Unterrainer, M., additional, Bartos, L.M., additional, Ruf, V.C., additional, Wetzel, C., additional, Herms, J., additional, Riemenschneider, M.J., additional, Rupprecht, R., additional, Brendel, M., additional, Thon, N., additional, von Baumgarten, L., additional, Bartenstein, P., additional, Tonn, J.C., additional, and Albert, N.L., additional
- Published
- 2022
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19. Research Domain Criteria (RDoC) und ihr Zusammenhang zur Krankheitsschwere
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Förstner, B, additional, Tschorn, M, additional, Heinz, A, additional, Mathiak, K, additional, Schulze, T, additional, Schneider, F, additional, Kamp-Becker, I, additional, Meyer-Lindenberg, A, additional, Padberg, F, additional, Banaschewski, T, additional, Bauer, M, additional, Rupprecht, R, additional, Hans-Ulrich, W, additional, and Rapp, M, additional
- Published
- 2021
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20. Effects of Escitalopram and Relearning on Cortical and Subcortical Grey Matter in Healthy Humans
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Vanicek, T, primary, Reed, MB, additional, Seiger, R, additional, Godbersen, M, additional, Klöbl, M, additional, Unterholzner, J, additional, Spurny, B, additional, Gryglewski, G, additional, Handschuh, P, additional, Kraus, C, additional, Stimpfl, T, additional, Rupprecht, R, additional, Kasper, S, additional, and Lanzenberger, R, additional
- Published
- 2021
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21. Impact of TSPO polymorphism on [18F]GE-180binding in healthy and pseudoreference tissue of neurooncological and neurodegenerative disorders
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Vettermann, FJ, additional, Harris, S, additional, Schmitt, J, additional, Unterrainer, M, additional, Lindner, S, additional, Rauchmann, BS, additional, Palleis, C, additional, Milenkovic, VM, additional, Wetzel, CH, additional, Rupprecht, R, additional, Perneczky, R, additional, Höglinger, GU, additional, Levin, J, additional, Haass, C, additional, Tonn, JC, additional, Niyazi, M, additional, Bartenstein, P, additional, Albert, NL, additional, and Brendel, M, additional
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- 2021
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22. Voxel-weise Korrelation von Aminosäure- und TSPO-PET mit relativer Kontrastmittelanreicherung im T1-gewichteten MRT bei Gliomen
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Kaiser, L, additional, Holzgreve, A, additional, Vettermann, FJ, additional, Brosch-Lenz, J, additional, Gosewisch, A, additional, Böning, G, additional, Rupprecht, R, additional, Tonn, JC, additional, Bartenstein, P, additional, Ziegler, S, additional, and Albert, NL, additional
- Published
- 2021
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23. Darmflora und Depression
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Lima-Ojeda, J. M., primary, Rupprecht, R., additional, and Baghai, T. C., additional
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- 2020
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24. P.867Effects of etifoxine on general but not stress related expression of the translocator protein 18kDa (TSPO) in healthy subjects
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Bahr, L.M., primary, Mühlberger, A., additional, Rupprecht, R., additional, and Nothdurfter, C., additional
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- 2020
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25. P.749 Astrocytes prime a synaptic pruning in the prefrontal cortex upon antidepressant treatment
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Vivi, E., primary, Román, C., additional, Vogl, A.M., additional, Giusti, S.A., additional, Butz, E., additional, Neumann, I.D., additional, Refojo, D., additional, Rupprecht, R., additional, and Benedetto, B. Di, additional
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- 2020
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26. Prognostic value of 18F-GE-180 PET in newly diagnosed IDH-wildtype glioma prior to radiotherapy
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Nelwan, D, additional, Unterrainer, M, additional, Fleischmann, DF, additional, von Rohr, K, additional, Rupprecht, R, additional, Tonn, JC, additional, Belka, C, additional, Bartenstein, P, additional, Niyazi, M, additional, and Albert, NL, additional
- Published
- 2020
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27. TSPO PET, tumour grading and molecular genetics in histologically verified glioma: a correlative 18F-GE-180 PET study
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Unterrainer, M., primary, Fleischmann, D. F., additional, Vettermann, F., additional, Ruf, V., additional, Kaiser, L., additional, Nelwan, D., additional, Lindner, S., additional, Brendel, M., additional, Wenter, V., additional, Stöcklein, S., additional, Herms, J., additional, Milenkovic, V. M., additional, Rupprecht, R., additional, Tonn, J. C., additional, Belka, C., additional, Bartenstein, P., additional, Niyazi, M., additional, and Albert, N. L., additional
- Published
- 2019
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28. TSPO PET, tumour grading and molecular genetics in histologically verified glioma: a correlative 18F-GE-180 PET study
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Unterrainer, M, additional, Fleischmann, DF, additional, Vettermann, F, additional, Ruf, V, additional, Kaiser, L, additional, Nelwan, D, additional, Lindner, S, additional, Brendel, M, additional, Wenter, V, additional, Stöcklein, S, additional, Herms, J, additional, Milenkovic, V, additional, Rupprecht, R, additional, Tonn, JC, additional, Belka, C, additional, Bartenstein, P, additional, Niyazi, M, additional, and Albert, NL, additional
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- 2019
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29. Abstract # 3139 Positive association of IL-6 and IL-6/IL-10 ratio with psychosocial health and well-being in highly functional Nonagerians
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Rohleder, N., primary, Rupprecht, R., additional, and Lang, F.R., additional
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- 2019
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30. Prediction of future falls in a community dwelling older adult population using instrumented balance and gait analysis
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Bauer, Christoph, Gröger, I., Rupprecht, R., Marcar, V.L., Gaßmann, K.G., Bauer, Christoph, Gröger, I., Rupprecht, R., Marcar, V.L., and Gaßmann, K.G.
- Abstract
Background: The role of instrumented balance and gait assessment when screening for prospective fallers is currently a topic of controversial discussion. Objectives: This study analyzed the association between variables derived from static posturography, instrumented gait analysis and clinical assessments with the occurrence of prospective falls in a sample of community dwelling older people. Methods: In this study 84 older people were analyzed. Based on a prospective occurrence of falls, participants were categorized into fallers and non-fallers. Variables derived from clinical assessments, static posturography and instrumented gait analysis were evaluated with respect to the association with the occurrence of prospective falls using a forward stepwise, binary, logistic regression procedure. Results: Fallers displayed a significantly shorter single support time during walking while counting backwards, increased mediolateral to anteroposterior sway amplitude ratio, increased fast mediolateral oscillations and a larger coefficient (Coeff) of sway direction during various static posturography tests. Previous falls were insignificantly associated with the occurrence of prospective falls. Conclusion: Variables derived from posturography and instrumented gait analysis showed significant associations with the occurrence of prospective falls in a sample of community dwelling older adults.
- Published
- 2018
31. Reliabilität der statischen Posturografie bei älteren Personen
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Bauer, Christoph, Gröger, I., Rupprecht, R., Tibesku, C.O., Gaßmann, K.G., Bauer, Christoph, Gröger, I., Rupprecht, R., Tibesku, C.O., and Gaßmann, K.G.
- Abstract
Erworben im Rahmen der Schweizer Nationallizenzen (http://www.nationallizenzen.ch), Hintergrund und Zielsetzung: Die statische Posturografie ist eine Messmethode für die Bewegungen des Körperdruckpunktes. Mit ihr werden beispielsweise ältere sturzgefährdete Patienten untersucht. Ob die statische Posturografie ein reliables Messinstrument bei älteren Menschen ist, konnte bisher nicht endgültig geklärt werden. Mit der vorliegenden Arbeit sollte die intraindividuelle Reliabilität der statischen Posturografie bei älteren Senioren geprüft werden. Probanden und Methode: Die intraindividuelle Reliabilität von 11 Messparametern der statischen Posturografie wurde bei 30 älteren Senioren untersucht. Messparameter waren: die Durchschnittsgeschwindigkeit der Druckpunktbewegung in mm/s, die Länge der Druckpunktbewegung in mm, die Schwankungsfläche in mm2, die Amplituden der Druckpunktbewegung, die Oszillationsachse in Grad und die Neigungswinkel der Patienten in Grad. Die drei Messungen fanden am selben Tag im Abstand von zwei Minuten statt. Sie wurden in vier verschiedenen Testpositionen durchgeführt: normaler Stand und Nahstand, jeweils mit offenen und geschlossenen Augen. Die statistische Analyse erfolgte mit Intra-Klassen-Korrelationskoeffizienten. Ergebnisse: Sechs der getesteten Parameter sind sehr gut reliabel, mit einem Korrelationskoeffizienten von jeweils >0,9. Diese sechs Parameter sind: die Durchschnittsgeschwindigkeit der Bewegung des Körperdruckpunktes in mm/s im Nahstand, die Schwankungsfläche in mm2 (im Nahstand mit geschlossenen Augen), die Länge der Druckpunktbewegung in mm (gesamt und in beiden Ebenen) im Normalstand und im Nahstand sowie der Neigungswinkel des Patienten in Grad in der Sagittalebene, im Normalstand und im Nahstand. Von den vier Testpositionen ist die Position „Nahstand mit geschlossenen Augen“ am besten geeignet, um reliable Werte zu erhalten. Schlussfolgerung: Sechs der getesteten Parameter können zur Verwendung in Folgestudien empfohlen werden. Als Testposition eignet sich die Position „Nahstand mit geschlossenen Augen“. Da
- Published
- 2018
32. Reliabilität der statischen Posturografie bei älteren Personen
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Bauer, C.M., Gröger, I., Rupprecht, R., Tibesku, C.O., Gaßmann, K.G., Bauer, C.M., Gröger, I., Rupprecht, R., Tibesku, C.O., and Gaßmann, K.G.
- Abstract
Zusammenfassung: Hintergrund und Zielsetzung: Die statische Posturografie ist eine Messmethode für die Bewegungen des Körperdruckpunktes. Mit ihr werden beispielsweise ältere sturzgefährdete Patienten untersucht. Ob die statische Posturografie ein reliables Messinstrument bei älteren Menschen ist, konnte bisher nicht endgültig geklärt werden. Mit der vorliegenden Arbeit sollte die intraindividuelle Reliabilität der statischen Posturografie bei älteren Senioren geprüft werden. Probanden und Methode: Die intraindividuelle Reliabilität von 11Messparametern der statischen Posturografie wurde bei 30 älteren Senioren untersucht. Messparameter waren: die Durchschnittsgeschwindigkeit der Druckpunktbewegung in mm/s, die Länge der Druckpunktbewegung in mm, die Schwankungsfläche in mm2, die Amplituden der Druckpunktbewegung, die Oszillationsachse in Grad und die Neigungswinkel der Patienten in Grad. Die drei Messungen fanden am selben Tag im Abstand von zwei Minuten statt. Sie wurden in vier verschiedenen Testpositionen durchgeführt: normaler Stand und Nahstand, jeweils mit offenen und geschlossenen Augen. Die statistische Analyse erfolgte mit Intra-Klassen-Korrelationskoeffizienten. Ergebnisse: Sechs der getesteten Parameter sind sehr gut reliabel, mit einem Korrelationskoeffizienten von jeweils >0,9. Diese sechs Parameter sind: die Durchschnittsgeschwindigkeit der Bewegung des Körperdruckpunktes in mm/s im Nahstand, die Schwankungsfläche in mm2 (im Nahstand mit geschlossenen Augen), die Länge der Druckpunktbewegung in mm (gesamt und in beiden Ebenen) im Normalstand und im Nahstand sowie der Neigungswinkel des Patienten in Grad in der Sagittalebene, im Normalstand und im Nahstand. Von den vier Testpositionen ist die Position "Nahstand mit geschlossenen Augen" am besten geeignet, um reliable Werte zu erhalten. Schlussfolgerung: Sechs der getesteten Parameter können zur Verwendung in Folgestudien empfohlen werden. Als Testposition eignet sich die Position "Nahstand mit geschlos
- Published
- 2018
33. Search for Charged Higgs Bosons Produced via Vector Boson Fusion and Decaying into a Pair of W and Z Bosons Using pp Collisions at root s=13 TeV
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Sirunyan, and Tumasyan, A. M., and Adam, A., and Asilar, W., and Bergauer, E., and Brandstetter, T., and Brondolin, J., and Dragicevic, E., and Eroe, M., and Flechl, J., and Friedl, M., and Fruhwirth, M., and Ghete, R., and Hartl, V. M., and Hormann, C., and Hrubec, N., and Jeitler, J., and Koenig, M., and Kratschmer, A., and Liko, I., and Matsushita, D., and Mikulec, T., and Rabady, I., and Rad, D., and Rahbaran, N., and Rohringer, B., and Schieck, H., and Strauss, J., and Waltenberger, J., and Wulz, W., and Dvornikov, C. -E., and Makarenko, O., and Mossolov, V., and Gonzalez, V., Suarez and Zykunov, J., and Shumeiko, V., and Alderweireldt, N., and De Wolf, S., and Janssen, E. A., and Lauwers, X., and Van De Klundert, J., and Van Haevermaet, M., and Van Mechelen, H., and Van Remortel, P., and Van Spilbeeck, N., and Abu Zeid, A., and Blekman, S., and D'Hondt, F., and Daci, J., and De Bruyn, N., and Deroover, I., and Lowette, K., and Moortgat, S., and Moreels, S., and Olbrechts, L., and Python, A., and Skovpen, Q., and Tavernier, K., and Van Doninck, S., and Van Mulders, W., and Van Parijs, P., and Brun, I., and Clerbaux, H., and De Lentdecker, B., and Delannoy, G., and Fasanella, H., and Favart, G., and Goldouzian, L., and Grebenyuk, R., and Karapostoli, A., and Lenzi, G., and Leonard, T., and Luetic, A., and Maerschalk, J., and Marinov, T., and Randle-Conde, A., and Seva, A., and Velde, T., Vander and Vanlaer, C., and Vannerom, P., and Yonamine, D., and Zenoni, R., and Zhang, F., and Cornelis, F., and Dobur, T., and Fagot, D., and Gul, A., and Khvastunov, M., and Poyraz, I., and Salva, D., and Schofbeck, S., and Tytgat, R., and Van Driessche, M., and Verbeke, W., and Zaganidis, W., and Bakhshiansohi, N., and Bondu, H., and Brochet, O., and Bruno, S., and Caudron, G., and De Visscher, A., and Delaere, S., and Delcourt, C., and Francois, M., and Giammanco, B., and Jafari, A., and Komm, A., and Krintiras, M., and Lemaitre, G., and Magitteri, V., and Mertens, A., and Musich, A., and Piotrzkowski, M., and Quertenmont, K., and Marono, L., Vidal and Wertz, M., and Beliy, S., and Alda Junior, N., and Alves, W. L., and Alves, F. L., and Brito, G. A., and Hensel, L., and Moraes, C., and Pol, A., and Rebello Teles, M. E., and Belchior Batista Das Chagas, P., and Carvalho, E., and Chinellato, W., and Custodio, J., and Da Costa, A., and Da Silveira, E. M., and De Jesus Damiao, G. G., and De Oliveira Martins, D., and Fonseca De Souza, C., and Huertas Guativa, S., and Malbouisson, L. M., and Matos Figueiredo, H., and Mora Herrera, D., and Mundim, C., and Nogima, L., and Prado Da Silva, H., and Santoro, W. L., and Sznajder, A., and Tonelli Manganote, A., and Torres Da Silva De Araujo, E. J., and Vilela Pereira, F., and Ahuja, A., and Bernardes, S., and Dogra, C. A., and Fernandez Perez Tomei, S., and Gregores, T. R., and Mercadante, E. M., and Moon, P. G., and Novaes, C. S., and Padula, S. F., and Romero Abad, Sandra S., and Ruiz Vargas, D., and Aleksandrov, J. C., and Hadjiiska, A., and Iaydjiev, R., and Rodozov, P., and Stoykova, M., and Sultanov, S., and Vutova, G., and Dimitrov, M., and Glushkov, A., and Litov, I., and Pavlov, L., and Petkov, B., and Fang, P., and Gao, W., and Ahmad, X., and Bian, M., and Chen, J. G., and Chen, G. M., and Chen, H. S., and Chen, M., and Cheng, Y., and Jiang, T., and Leggat, C. H., and Liu, D., and Romeo, Z., and Ruan, F., and Shaheen, M., and Spiezia, S. M., and Tao, A., and Wang, J., and Wang, C., and Yazgan, Z., and Zhang, E., and Zhao, H., and Ban, J., and Chen, Y., and Li, G., and Liu, Q., and Mao, S., and Qian, Y., and Wang, S. J., and Xu, D., and Avila, Z., and Cabrera, C., and Chaparro Sierra, A., and Florez, L. F., and Gomez, C., and Gonzalez Hernandez, J. P., and Ruiz Alvarez, C. F., and Sanabria, J. D., and Godinovic, J. C., and Lelas, N., and Puljak, D., and Cipriano, I., Ribeiro and Sculac, P. 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Problems, National Centre for Particle and High Energy Physics, Universiteit Antwerpen, Vrije Universiteit Brussel, Université Libre de Bruxelles, Ghent University, Université Catholique de Louvain, Université de Mons, Centro Brasileiro de Pesquisas Fisicas, Universidade Estadual Paulista (UNESP), Institute for Nuclear Research and Nuclear Energy, University of Sofia, Beihang University, Institute of High Energy Physics, Peking University, Universidad de Los Andes, Mechanical Engineering and Naval Architecture, Faculty of Science, Institute Rudjer Boskovic, University of Cyprus, Charles University, Universidad San Francisco de Quito, Egyptian Network of High Energy Physics, National Institute of Chemical Physics and Biophysics, University of Helsinki, Helsinki Institute of Physics, Lappeenranta University of Technology, Université Paris-Saclay, IPHC UMR 7178, CNRS/IN2P3, Institut de Physique Nucléaire de Lyon, Georgian Technical University, Tbilisi State University, I. Physikalisches Institut, III. Physikalisches Institut A, III. Physikalisches Institut B, Deutsches Elektronen-Synchrotron, University of Hamburg, Institut für Experimentelle Kernphysik, National and Kapodistrian University of Athens, National Technical University of Athens, University of Ioánnina, Eötvös Loránd University, Wigner Research Centre for Physics, ATOMKI, University of Debrecen, Indian Institute of Science (IISc), National Institute of Science Education and Research, Panjab University, University of Delhi, Saha Institute of Nuclear Physics, Indian Institute of Technology Madras, Bhabha Atomic Research Centre, Tata Institute of Fundamental Research-A, Tata Institute of Fundamental Research-B, Indian Institute of Science Education and Research (IISER), Institute for Research in Fundamental Sciences (IPM), University College Dublin, Sezione di Bari, Università di Bari, Politecnico di Bari, Sezione di Bologna, Università di Bologna, Sezione di Catania, Università di Catania, Sezione di Firenze, Università di Firenze, Laboratori Nazionali di Frascati, Sezione di Genova, Università di Genova, Sezione di Milano-Bicocca, Università di Milano-Bicocca, Sezione di Napoli, Università di Napoli 'Federico II', Università della Basilicata, Università G. 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Lebedev Physical Institute, Lomonosov Moscow State University, Novosibirsk State University (NSU), Institute for High Energy Physics, Vinca Institute of Nuclear Sciences, Centro de Investigaciones Energéticas Medioambientales y Tecnológicas (CIEMAT), Universidad Autónoma de Madrid, Universidad de Oviedo, Universidad de Cantabria, European Organization for Nuclear Research, Paul Scherrer Institut, ETH Zurich, Universität Zürich, National Central University, National Taiwan University (NTU), Science and Art Faculty, Physics Department, Bogazici University, Istanbul Technical University, National Academy of Science of Ukraine, Kharkov Institute of Physics and Technology, University of Bristol, Rutherford Appleton Laboratory, Imperial College, Brunel University, Baylor University, Catholic University of America, The University of Alabama, Boston University, Brown University, Davis, University of California, Riverside, San Diego, Santa Barbara, California Institute of Technology, Carnegie Mellon University, University of Colorado Boulder, Cornell University, Fairfield University, Fermi National Accelerator Laboratory, University of Florida, Florida International University, Florida State University, Florida Institute of Technology, University of Illinois at Chicago (UIC), University of Iowa, Johns Hopkins University, University of Kansas, Kansas State University, Lawrence Livermore National Laboratory, University of Maryland, Massachusetts Institute of Technology, University of Minnesota, University of Mississippi, University of Nebraska-Lincoln, State University of New York at Buffalo, Northeastern University, Northwestern University, University of Notre Dame, Ohio State University, Princeton University, University of Puerto Rico, Purdue University, Purdue University Northwest, Rice University, University of Rochester, State University of New Jersey, University of Tennessee, Texas A and M University, Texas Tech University, Vanderbilt University, University of Virginia, Wayne State University, University of Wisconsin - Madison, Vienna University of Technology, Universidade Federal de Pelotas, Universidad de Antioquia, Helwan University, Zewail City of Science and Technology, Fayoum University, British University in Egypt, Ain Shams University, Université de Haute Alsace, Brandenburg University of Technology, Univer. of Debrecen, University of Visva-Bharati, Institute of Physics, University of Ruhuna, Isfahan University of Technology, Yazd University, Islamic Azad University, Università degli Studi di Siena, International Islamic University of Malaysia, MOSTI, Consejo Nacional de Ciencia y Tecnología, Institute of Electronic Systems, St. Petersburg State Polytechnical University, Budker Institute of Nuclear Physics, University of Belgrade, Scuola Normale e Sezione dell'Infn, Riga Technical University, Albert Einstein Center for Fundamental Physics, Adiyaman University, Istanbul Aydin University, Mersin University, Cag University, Piri Reis University, Gaziosmanpasa University, Ozyegin University, Izmir Institute of Technology, Marmara University, Kafkas University, Istanbul Bilgi University, Yildiz Technical University, Hacettepe University, University of Southampton, Instituto de Astrofísica de Canarias, Utah Valley University, Beykent University, Erzincan University, Istanbul, and Texas A and M University at Qatar
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transverse momentum: missing-energy ,13000 GeV-cms ,NEUTRINO MASSES ,ATLAS DETECTOR ,final state: ((n)jet 3lepton) ,vector boson: fusion ,ddc:550 ,scattering [p p] ,((n)jet 3lepton) [final state] ,Nuclear Experiment ,Neutrino Masses ,Broken Symmetries ,Gauge ,Mixings ,Models ,Weak ,High energy physics ,Tellurium compounds ,Bosons ,Higgs bosons ,02 Physical Sciences ,PARITY ,CMS ,Physics ,Settore FIS/01 - Fisica Sperimentale ,triplet [model] ,Vector Boson Fusion ,mass dependence ,channel cross section: branching ratio: upper limit ,CERN LHC Coll ,Physical Sciences ,CMS Collaboration ,SYMMETRIES ,Centre for High Energy Physics ,charged particle [Higgs particle] ,MIXINGS ,LHC ,colliding beams [p p] ,Higgs particle: triplet ,LEFT-RIGHT SYMMETRY ,MASSLESS PARTICLES ,BROKEN ,GAUGE ,VIOLATION ,MODEL ,dijet: mass ,p p: scattering ,General Physics ,Higgs boson ,Higgs particle: charged particle ,MODELS ,Physics, Multidisciplinary ,Physics and Astronomy (all) ,proton-proton collisions ,fusion [vector boson] ,NEUTRINO MASSES, BROKEN SYMMETRIES, GAUGE, MIXINGS, MODELS, WEAK ,mass [dijet] ,BROKEN SYMMETRIES ,model: triplet ,CMS DETECTOR ,triplet [Higgs particle] ,Science & Technology ,branching ratio: upper limit [channel cross section] ,High Energy Physics::Phenomenology ,Aerospace Engineering(Formerly Aeronautical Engineering) ,rapidity ,Physics and Astronomy ,Higgs ,LHC, Charged Higgs Bosons, Vector Boson Fusion, proton-proton collisions ,missing-energy [transverse momentum] ,High Energy Physics::Experiment ,WEAK ,p p: colliding beams ,experimental results - Abstract
Physical review letters 119(14), 141802 (2017). doi:10.1103/PhysRevLett.119.141802, Published by American Physical Society, College Park, Md.
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34. Supplementary Material for: Dose Escalation of Antidepressants in Unipolar Depression: A Meta-Analysis of Double-Blind, Randomized Controlled Trials
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Dold, M., Bartova, L., Rupprecht, R., and Kasper, S.
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Background: As many patients with unipolar depression do not respond sufficiently to initial antidepressant monotherapy, a dose increase of the current administered antidepressant (dose escalation, high-dose treatment) is frequently carried out as next treatment measure. Methods: We conducted a meta-analysis which included all double-blind randomized controlled trials (RCTs) comparing a dose increase of antidepressants directly to continuation of standard-dose treatment in unipolar depressive patients who were non- responders to standard-dose pharmacotherapy. A mean change in the Hamilton Rating Scale for Depression (HAM-D) total score was the primary outcome. Secondary outcomes were response rates and discontinuation rates due to any reason, inefficacy, and adverse effects. Hedges g and risk ratios were calculated as effect sizes. Results: Seven double-blind RCTs (8 study arms) representing 1,208 participants were included. Fluoxetine (N [number of studies] = 2, n [number of patients] = 448), sertraline (N = 2, n = 272), paroxetine (N = 2, n = 146), duloxetine (N = 1, n = 255), and maprotiline (N = 1, n = 87) were investigated. Dose escalation was not more efficacious in HAM-D total score reduction than maintaining standard-dose treatment, neither for the pooled antidepressant group (N = 7, n = 999; Hedges g = -0.04, 95% CI: -0.20 to 0.12; p = 0.63) nor the individual antidepressants. No differences could be determined for response rates, all-cause discontinuation, and drop-outs due to inefficacy. Significantly more patients in the dose escalation group dropped out due to adverse effects than in the standard-dose continuation group. The metaregressions indicate no influence of baseline symptom severity or amounts of dose increments on effect sizes. Conclusions: According to our meta-analytic findings, dose escalation after initial non-response to standard-dose pharmacotherapy cannot be regarded as general evidence-based treatment option in unipolar depression.
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35. Supplementary Material for: Macrophage-Derived Chemokine: A Putative Marker of Pharmacological Therapy Response in Major Depression?
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Milenkovic, V.M., Sarubin, N., Hilbert, S., Baghai, T.C., Stöffler, F., Lima-Ojeda, J.M., Manook, A., Almeqbaali, K., Wetzel, C.H., Rupprecht, R., and Nothdurfter, C.
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Introduction: Inflammatory processes play an important and complex role in the pathophysiology of major depressive disorder (MDD), but, so far, no specific investigation of chemokines exists. Methods: In this study, we investigated the changes of plasma chemokine levels (eotaxin-1, eotaxin-3, IP-10, MCP-1, MCP-4, MDC, MIP-1α, MIP-1β, and TARC) in 47 MDD patients before (PRE) and after 1 and 6 weeks of pharmacological treatment (POST1 and POST6) in relation to the response to antidepressive therapy. We hypothesized that the direction of alterations in levels of chemokines would significantly differ between the 2 groups, responders and nonresponders. Results: Among the investigated chemokines, only the level of macrophage-derived chemokine (MDC) changed significantly in relation to therapy response. MDC levels were significantly elevated in the responder group at POST6. Discussion: MDC is a constitutively expressed chemokine involved in the pathophysiology of infectious and neoplastic diseases. This is the first study providing valuable hints that MDC might serve as a marker of pharmacological therapy response in MDD.
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36. Search for new physics in the monophoton final state in proton-proton collisions at root s=13 TeV
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Sirunyan, and Tumasyan, A. M., and Adam, A., and Asilar, W., and Bergauer, E., and Brandstetter, T., and Brondolin, J., and Dragicevic, E., and Eroe, M., and Flechl, J., and Friedl, M., and Fruehwirth, M., and Ghete, R., and Hartl, V. M., and Hoermann, C., and Hrubec, N., and Jeitler, J., and Koenig, M., and Kraetschmer, A., and Liko, I., and Matsushita, D., and Mikulec, T., and Rabady, I., and Rad, D., and Rahbaran, N., and Rohringer, B., and Schieck, H., and Strauss, J., and Waltenberger, J., and Wulz, W., and Dvornikov, C. -E., and Makarenko, O., and Mossolov, V., and Gonzalez, V., Suarez and Zykunov, J., and Shumeiko, V., and Alderweireldt, N., and De Wolf, S., and Janssen, E. A., and Lauwers, X., and Van De Klundert, J., and Van Haevermaet, M., and Van Mechelen, H., and Van Remortel, P., and Van Spilbeeck, N., and Abu Zeid, A., and Blekman, S., and D'Hondt, F., and Daci, J., and De Bruyn, N., and Deroover, I., and Lowette, K., and Moortgat, S., and Moreels, S., and Olbrechts, L., and Python, A., and Skovpen, Q., and Tavernier, K., and Van Doninck, S., and Van Mulders, W., and Van Parijs, P., and Brun, I., and Clerbaux, H., and De Lentdecker, B., and Delannoy, G., and Fasanella, H., and Favart, G., and Goldouzian, L., and Grebenyuk, R., and Karapostoli, A., and Lenzi, G., and Leonard, T., and Luetic, A., and Maerschalk, J., and Marinov, T., and Randle-conde, A., and Seva, A., and Vander Velde, T., and Vanlaer, C., and Vannerom, P., and Yonamine, D., and Zenoni, R., and Zhang, F., and Cornelis, F., and Dobur, T., and Fagot, D., and Gul, A., and Khvastunov, M., and Poyraz, I., and Salva, D., and Schofbeck, S., and Tytgat, R., and Van Driessche, M., and Verbeke, W., and Zaganidis, W., and Bakhshiansohi, N., and Bondu, H., and Brochet, O., and Bruno, S., and Caudron, G., and De Visscher, A., and Delaere, S., and Delcourt, C., and Francois, M., and Giammanco, B., and Jafari, A., and Komm, A., and Krintiras, M., and Lemaitre, G., and Magitteri, V., and Mertens, A., and Musich, A., and Piotrzkowski, M., and Quertenmont, K., and Marono, L., Vidal and Wertz, M., and Beliy, S., and Alda Junior, N., and Alves, W. L., and Alves, F. L., and Brito, G. A., and Hensel, L., and Moraes, C., and Pol, A., and Rebello Teles, M. E., and Belchior Batista Das Chagas, P., and Carvalho, E., and Chinellato, W., and Custodio, J., and Da Costa, A., and Da Silveira, E. M., and De Jesus Damiao, G. G., and De Oliveira Martins, D., and Fonseca De Souza, C., and Huertas Guativa, S., and Malbouisson, L. M., and Matos Figueiredo, H., and Mora Herrera, D., and Mundim, C., and Nogima, L., and Prado Da Silva, H., and Santoro, W. L., and Sznajder, A., and Tonelli Manganote, A., and Torres Da Silva De Araujo, E. J., and Vilela Pereira, F., and Ahuja, A., and Bernardes, S., and Dogra, C. A., and Fernandez Perez Tomei, S., and Gregores, T. R., and Mercadante, E. M., and Moon, P. G., and Novaes, C. S., and Padula, S. F., and Romero Abad, Sandra S., and Ruiz Vargas, D., and Aleksandrov, J. C., and Hadjiiska, A., and Iaydjiev, R., and Rodozov, P., and Stoykova, M., and Sultanov, S., and Vutova, G., and Dimitrov, M., and Glushkov, A., and Litov, I., and Pavlov, L., and Petkov, B., and Fang, P., and Gao, W., and Ahmad, X., and Bian, M., and Chen, J. G., and Chen, G. M., and Chen, H. S., and Chen, M., and Cheng, Y., and Jiang, T., and Leggat, C. H., and Liu, D., and Romeo, Z., and Ruan, F., and Shaheen, M., and Spiezia, S. M., and Tao, A., and Wang, J., and Wang, C., and Yazgan, Z., and Zhang, E., and Zhao, H., and Ban, J., and Chen, Y., and Li, G., and Liu, Q., and Mao, S., and Qian, Y., and Wang, S. J., and Xu, D., and Avila, Z., and Cabrera, C., and Chaparro Sierra, A., and Florez, L. F., and Gomez, C., and Gonzalez Hernandez, J. P., and Ruiz Alvarez, C. F., and Sanabria, J. D., and Godinovic, J. C., and Lelas, N., and Puljak, D., and Ribeiro Cipriano, I., and Sculac, P. M., and Antunovic, T., and Kovac, Z., and Brigljevic, M., and Ferencek, V., and Kadija, D., and Mesic, K., and Susa, B., and Ather, T., and Attikis, M. W., and Mavromanolakis, A., and Mousa, G., and Nicolaou, J., and Ptochos, C., and Razis, F., and Rykaczewski, P. A., and Finger, H., and Finger, M., J, R., and Carrera Jarrin, M., and El-khateeb, E., and Elgammal, E., and Mohamed, S., and Kadastik, A., and Perrini, M., and Raidal, L., and Tiko, M., and Veelken, A., and Eerola, C., and Pekkanen, P., and Voutilainen, J., and Harkonen, M., and Jarvinen, J., and Karimaki, T., and Kinnunen, V., and Lampen, R., and Lassila-Perini, T., and Lehti, K., and Linden, S., and Luukka, T., and Tuominiemi, P., and Tuovinen, J., and Wendland, E., and Talvitie, L., and Tuuva, J., and Besancon, T., and Couderc, M., and Dejardin, F., and Denegri, M., and Fabbro, D., and Faure, B., and Favaro, J. L., and Ferri, C., and Ganjour, F., and Ghosh, S., and Givernaud, S., and Gras, A., and de Monchenault, P., Hamel and Jarry, G., and Kucher, P., and Locci, I., and Machet, E., and Malcles, M., and Rander, J., and Rosowsky, J., and Titov, A., and Abdulsalam, M., and Antropov, A., and Baffioni, I., and Beaudette, S., and Busson, F., and Cadamuro, P., and Chapon, L., and Charlot, E., and Davignon, C., and de Cassagnac, O., Granier and Jo, R., and Lisniak, M., and Lobanov, S., and Mine, A., and Nguyen, P., and Ochando, M., and Ortona, C., and Paganini, G., and Pigard, P., and Regnard, P., and Salerno, S., and Sirois, R., and Leiton, Y., Stahl and Strebler, A. G., and Yilmaz, T., and Zabi, Y., and Zghiche, A., and Agram, A., and Andrea, J. -L., and Bloch, J., and Brom, D., and Buttignol, J. -M., and Chabert, M., and Chanon, E. C., and Collard, N., and Conte, C., and Coubez, E., and Fontaine, X., and Gele, J. -C., and Goerlach, D., and Le Bihan, U., and Van Hove, A. -C., and Gadrat, P., and Beauceron, S., and Bernet, S., and Boudoul, C., and Montoya, G., Carrillo and Chierici, C. A., and Contardo, R., and Courbon, D., and Depasse, B., and El Mamouni, P., and Fay, H., and Finco, J., and Gascon, L., and Gouzevitch, S., and Grenier, M., and Ille, G., and Lagarde, B., and Laktineh, F., and Lethuillier, I. B., and Mirabito, M., and Pequegnot, L., and Perries, A. L., and Popov, S., and Sordini, A., and Vander Donckt, V., and Verdier, M., and Viret, P., and Khvedelidze, S., and Tsamalaidze, A., and Autermann, Z., and Beranek, C., and Feld, S., and Kiesel, L., and Klein, M. K., and Lipinski, K., and Preuten, M., and Schomakers, M., and Schulz, C., and Verlage, J., and Albert, T., and Brodski, A., and Dietz-Laursonn, M., and Duchardt, E., and Endres, D., and Erdmann, M., and Erdweg, M., and Esch, S., and Fischer, T., and Gueth, R., and Hamer, A., and Hebbeker, M., and Heidemann, T., and Hoepfner, C., and Knutzen, K., and Merschmeyer, S., and Meyer, M., and Millet, A., and Mukherjee, P., and Olschewski, S., and Padeken, M., and Pook, K., and Radziej, T., and Reithler, M., and Rieger, H., and Scheuch, M., and Sonnenschein, F., and Teyssier, L., and Thueer, D., and Cherepanov, S., and Fluegge, V., and Kargoll, G., and Kress, B., and Kuensken, T., and Lingemann, A., and Mueller, J., and Nehrkorn, T., and Nowack, A., and Pistone, A., and Pooth, C., and Stahl, O., and Martin, A., Aldaya and Arndt, M., and Asawatangtrakuldee, T., and Beernaert, C., and Behnke, K., and Behrens, O., and Bin Anuar, U., and Borras, A. A., and Campbell, K., and Connor, A., and Contreras-Campana, P., and Costanza, C., and Pardos, F., Diez and Dolinska, C., and Eckerlin, G., and Eckstein, G., and Eichhorn, D., and Eren, T., and Gallo, E., and Garcia, E., Garay and Geiser, J., and Gizhko, A., and Luyando, A., Grados and Grohsjean, J. M., and Gunnellini, A., and Harb, P., and Hauk, A., and Hempel, J., and Jung, M., and Kalogeropoulos, H., and Karacheban, A., and Kasemann, O., and Keaveney, M., and Kleinwort, J., and Korol, C., and Kruecker, I., and Lange, D., and Lelek, W., and Lenz, A., and Lipka, J., and Lohmann, K., and Mankel, W., and Melzer-Pellmann, R., and Meyer, I. -A., and Mittag, A. B., and Mnich, G., and Mussgiller, J., and Ntomari, A., and Pitzl, E., and Placakyte, D., and Raspereza, R., and Roland, A., and Sahin, B., and Saxena, M. Oe., and Schoerner-Sadenius, P., and Spannagel, T., and Stefaniuk, S., and Van Onsem, N., and Walsh, G. P., and Wissing, R., and Blobel, C., and Vignali, V., Centis and Draeger, M., and Dreyer, A. R., and Garutti, T., and Gonzalez, E., and Haller, D., and Hoffmann, J., and Junkes, M., and Klanner, A., and Kogler, R., and Kovalchuk, R., and Kurz, N., and Lapsien, S., and Marchesini, T., and Marconi, I., and Meyer, D., and Niedziela, M., and Nowatschin, M., and Pantaleo, D., and Peiffer, F., and Perieanu, T., and Scharf, A., and Schleper, C., and Schmidt, P., and Schumann, A., and Schwandt, S., and Sonneveld, J., and Stadie, J., and Steinbrueck, H., and Stober, G., and Stoever, F. M., and Tholen, M., and Troendle, H., and Usai, D., and Vanelderen, E., and Vanhoefer, L., and Vormwald, A., and Akbiyik, B., and Barth, M., and Baur, C., and Baus, S., and Berger, C., and Butz, J., and Caspart, E., and Chwalek, R., and Colombo, T., and De Boer, F., and Dierlamm, W., and Fink, A., and Freund, S., and Friese, B., and Giffels, R., and Gilbert, M., and Goldenzweig, A., and Haitz, P., and Hartmann, D., and Heindl, F., and Husemann, S. M., and Kassel, U., and Katkov, F., and Kudella, I., and Mildner, S., and Mozer, H., and Mueller, M. U., and Plagge, Th., and Quast, M., and Rabbertz, G., and Roecker, K., and Roscher, S., and Schroeder, F., and Shvetsov, M., and Sieber, I., and Simonis, G., and Ulrich, H. J., and Wayand, R., and Weber, S., and Weiler, M., and Williamson, T., and Woehrmann, S., and Wolf, C., and Anagnostou, R., and Daskalakis, G., and Geralis, G., and Giakoumopoulou, T., and Kyriakis, V. A., and Loukas, A., and Topsis-Giotis, D., and Kesisoglou, I., and Panagiotou, S., and Saoulidou, A., and Tziaferi, N., and Kousouris, E., and Evangelou, K., and Flouris, I., and Foudas, G., and Kokkas, C., and Loukas, P., and Manthos, N., and Papadopoulos, N., and Paradas, I., and Triantis, E., and Filipovic, F. A., and Pasztor, N., and Bencze, G., and Hajdu, G., and Horvath, C., and Sikler, D., and Veszpremi, F., and Vesztergombi, V., and Zsigmond, G., and Beni, A. J., and Czellar, N., and Karancsi, S., and Makovec, J., and Molnar, A., and Szillasi, J., and Bartok, Z., and Raics, M., and Trocsanyi, P., and Ujvari, Z. L., and Komaragiri, B., and Bahinipati, J. R., and Bhowmik, S., and Choudhury, S., and Mal, S., and Mandal, P., and Nayak, K., and Sahoo, A., and Sahoo, D. K., and Swain, N., and Bansal, S. K., and Beri, S., and Bhatnagar, S. B., and Bhawandeep, V., and Chawla, U., and Kalsi, R., and Kaur, A. K., and Kaur, A., and Kumar, M., and Kumari, R., and Mehta, P., and Mittal, A., and Singh, M., and Walia, J. B., and Kumar, G., Ashok and Bhardwaj, and Choudhary, A., and Garg, B. C., and Keshri, R. B., and Kumar, S., and Malhotra, A., and Naimuddin, S., and Ranjan, M., and Sharma, K., and Sharma, R., and Bhattacharya, V., and Bhattacharya, R., and Chatterjee, S., and Dey, K., and Dutt, S., and Dutta, S., and Majumdar, S., and Modak, N., and Mondal, A., and Mukhopadhyay, K., and Nandan, S., and Purohit, S., and Roy, A., and Chowdhury, D., Roy and Sarkar, S., and Sharan, S., and Thakur, M., and Behera, S., and Chudasama, P. K., and Dutta, R., and Jha, D., and Kumar, V., and Mohanty, V., and Netrakanti, A. K., and Pant, P. K., and Shukla, L. M., and Topkar, P., and Aziz, A., and Dugad, T., and Kole, S., and Mahakud, G., and Mitra, B., and Mohanty, S., and Parida, G. B., and Sur, B., and Sutar, N., and Banerjee, B., and Dewanjee, S., and Ganguly, R. 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M., and Najafabadi, M., Mohammadi and Naseri, M., and Mehdiabadi, M., Paktinat and Hosseinabadi, S., Rezaei and Safarzadeh, F., and Zeinali, B., and Felcini, M., and Grunewald, M., and Abbrescia, M., and Calabria, M., and Caputo, C., and Colaleo, C., and Creanza, A., and Cristella, D., and De Filippis, L., and De Palma, N., and Fiore, M., and Iaselli, L., and Maggi, G., and Miniello, M., and My, G., and Nuzzo, S., and Pompili, S., and Pugliese, A., and Radogna, G., and Ranieri, R., and Selvaggi, A., and Sharma, G., and Silvestris, A., and Venditti, L., and Verwilligen, R., and Abbiendi, P., and Battilana, G., and Bonacorsi, C., and Braibant-Giacomelli, D., and Brigliadori, S., and Campanini, L., and Capiluppi, R., and Castro, P., and Cavallo, A., and Chhibra, F. R., and Codispoti, S. S., and Cuffiani, G., and Dallavalle, M., and Fabbri, G. 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- Subjects
DIMENSIONS ,Science & Technology ,02 Physical Sciences ,Beyond Standard Model ,Dark matter ,Hadron-Hadron scattering ,(experiments) ,QUANTUM-GRAVITY ,DARK-MATTER ,Physics ,Nuclear & Particles Physics ,Physics, Particles & Fields ,Hadron-Hadron scattering (experiments) ,Physical Sciences ,Centre for High Energy Physics ,01 Mathematical Sciences - Abstract
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No. of bitstreams: 0 Previous issue date: 2017-10-11 BMWFW (Austria) FWF (Austria) FNRS (Belgium) FWO (Belgium) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) MES (Bulgaria) CERN CAS (China) MoST (China) NSFC (China) COLCIENCIAS (Colombia) MSES (Croatia) CSF (Croatia) RPF (Cyprus) SENESCYT (Ecuador) MoER (Estonia) ERC IUT (Estonia) ERDF (Estonia) Academy of Finland (Finland) MEC (Finland) HIP (Finland) CEA (France) CNRS/IN2P3 (France) BMBF (Germany) DFG (Germany) HGF (Germany) GSRT (Greece) OTKA (Hungary) NIH (Hungary) DAE (India) DST (India) IPM (Iran) SFI (Ireland) INFN (Italy) MSIP (Republic of Korea) NRF (Republic of Korea) LAS (Lithuania) MOE (Malaysia) UM (Malaysia) BUAP (Mexico) CINVESTAV (Mexico) CONACYT (Mexico) LNS (Mexico) SEP (Mexico) UASLP-FAI (Mexico) MBIE (New Zealand) PAEC (Pakistan) MSHE (Poland) NSC (Poland) FCT (Portugal) JINR (Dubna) MON (Russia) RosAtom (Russia) RAS (Russia) RFBR (Russia) RAEP (Russia) MESTD (Serbia) SEIDI (Spain) CPAN (Spain) PCTI (Spain) FEDER (Spain) Swiss Funding Agencies (Switzerland) MST (Taipei) ThEPCenter (Thailand) IPST (Thailand) STAR (Thailand) NSTDA (Thailand) TUBITAK (Turkey) TAEK (Turkey) NASU (Ukraine) SFFR (Ukraine) STFC (United Kingdom) DOE (U.S.A.) NSF (U.S.A.) Marie-Curie programme (European Union) European Research Council (European Union) Horizon Grant (European Union) Leventis Foundation A. P. Sloan Foundation Alexander von Humboldt Foundation Belgian Federal Science Policy Office Fonds pour la Formation a la Recherche dans l'Industrie et dans l'Agriculture (FRIA-Belgium) Agentschap voor Innovatie door Wetenschap en Technologie (IWT-Belgium) Ministry of Education, Youth and Sports (MEYS) of the Czech Republic Council of Science and Industrial Research, India HOMING PLUS programme of the Foundation for Polish Science European Union, Regional Development Fund Mobility Plus programme of the Ministry of Science and Higher Education National Science Center (Poland) National Priorities Research Program by Qatar National Research Fund Programa Clarin-COFUND del Principado de Asturias Thalis programme - EU-ESF Aristeia programme - EU-ESF Greek NSRF Rachadapisek Sompot Fund for Postdoctoral Fellowship, Chulalongkorn University Chulalongkorn Academic into Its 2nd Century Project Advancement Project (Thailand) Welch Foundation A search is conducted for new physics in a final state containing a photon and missing transverse momentum in proton-proton collisions at root s = 13 TeV. The data collected by the CMS experiment at the CERN LHC correspond to an integrated luminosity of 12.9 fb(-1). No deviations are observed relative to the predictions of the standard model. The results are interpreted as exclusion limits on the dark matter production cross sections and parameters in models containing extra spatial dimensions. Improved limits are set with respect to previous searches using the monophoton final state. In particular, the limits on the extra dimension model parameters are the most stringent to date in this channel. 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Prague, Prague, Czech Republic Univ San Francisco Quito, Quito, Ecuador Acad Sci Res & Technol Arab Republ Egypt, Egyptian Network High Energy Phys, Cairo, Egypt NICPB, Tallinn, Estonia Univ Helsinki, Dept Phys, Helsinki, Finland Helsinki Inst Phys, Helsinki, Finland Lappeenranta Univ Technol, Lappeenranta, Finland Univ Paris Saclay, IRFU, CEA, Gif Sur Yvette, France Univ Paris Saclay, Ecole Polytech, Lab Leprince Ringuet, CNRS IN2P3, Palaiseau, France Univ Strasbourg, CNRS, IPHC, UMR 7178, F-67000 Strasbourg, France Ctr Calcul Inst Natl Phys Nucl & Phys Particules, CNRS, IN2P3, Villeurbanne, France Univ Claude Bernard Lyon 1, CNRS, Inst Phys Nucl Lyon, IN2P3, Villeurbanne, France Georgian Tech Univ, Tbilisi, Georgia Tbilisi State Univ, Tbilisi, Georgia Rhein Westfal TH Aachen, Phys Inst 1, Aachen, Germany Rhein Westfal TH Aachen, Phys Inst A 3, Aachen, Germany Rhein Westfal TH Aachen, Phys Inst B 3, Aachen, Germany Deutsch Elekt Synchrotron, Hamburg, Germany Univ Hamburg, Hamburg, Germany Inst Expt Kernphys, Karlsruhe, Germany NCSR Demokritos, Inst Nucl & Particle Phys, Aghia Paraskevi, Greece Univ Athens, Athens, Greece Natl Tech Univ Athens, Athens, Greece Univ Ioannina, Ioannina, Greece Eotvos Lorand Univ, MTA ELTE Lendulet CMS Particle & Nucl Phys Grp, Budapest, Hungary Wigner Res Ctr Phys, Budapest, Hungary Inst Nucl Res ATOMKI, Debrecen, Hungary Univ Debrecen, Inst Phys, Debrecen, Hungary Indian Inst Sci IISc, Bangalore, Karnataka, India Natl Inst Sci Educ & Res, Bhubaneswar, Orissa, India Panjab Univ, Chandigarh, India Univ Delhi, Delhi, India Saha Inst Nucl Phys, HBNI, Kolkata, India Indian Inst Technol Madras, Madras, Tamil Nadu, India Bhabha Atom Res Ctr, Bombay, Maharashtra, India Tata Inst Fundamental Res A, Bombay, Maharashtra, India Tata Inst Fundamental Res B, Bombay, Maharashtra, India Indian Inst Sci Educ & Res, Pune, Maharashtra, India Inst Res Fundamental Sci IPM, Tehran, Iran Univ Coll Dublin, Dublin, Ireland INFN, Sez Bari, Bari, Italy Univ 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East Tech Univ, Phys Dept, Ankara, Turkey Bogazici Univ, Istanbul, Turkey Istanbul Tech Univ, Istanbul, Turkey Natl Acad Sci Ukraine, Inst Scintillat Mat, Kharkov, Ukraine Natl Sci Ctr, Kharkov Inst Phys & Technol, Kharkov, Ukraine Univ Bristol, Bristol, Avon, England Rutherford Appleton Lab, Didcot, Oxon, England Imperial Coll, London, England Brunel Univ, Uxbridge, Middx, England Baylor Univ, Waco, TX 76798 USA Catholic Univ Amer, Washington, DC 20064 USA Univ Alabama, Tuscaloosa, AL USA Boston Univ, Boston, MA 02215 USA Brown Univ, Providence, RI 02912 USA Univ Calif Davis, Davis, CA 95616 USA Univ Calif Los Angeles, Los Angeles, CA USA Univ Calif Riverside, Riverside, CA 92521 USA Univ Calif San Diego, San Diego, CA 92103 USA Univ Calif Santa Barbara, Dept Phys, Santa Barbara, CA 93106 USA CALTECH, Pasadena, CA 91125 USA Carnegie Mellon Univ, Pittsburgh, PA 15213 USA Univ Colorado, Boulder, CO 80309 USA Cornell Univ, Ithaca, NY USA Fairfield Univ, Fairfield, CT 06430 USA Fermilab Natl Accelerator Lab, POB 500, Batavia, IL 60510 USA Univ Florida, Gainesville, FL USA Florida Int Univ, Miami, FL 33199 USA Florida State Univ, Tallahassee, FL 32306 USA Florida Inst Technol, Melbourne, FL 32901 USA Univ Illinois, Chicago, IL 60680 USA Univ Iowa, Iowa City, IA USA Johns Hopkins Univ, Baltimore, MD USA Univ Kansas, Lawrence, KS 66045 USA Kansas State Univ, Manhattan, KS 66506 USA Lawrence Livermore Natl Lab, Livermore, CA USA Univ Maryland, College Pk, MD 20742 USA MIT, Cambridge, MA 02139 USA Univ Minnesota, Minneapolis, MN USA Univ Mississippi, Oxford, MS USA Univ Nebraska, Lincoln, NE USA SUNY Buffalo, Buffalo, NY USA Northeastern Univ, Boston, MA 02115 USA Northwestern Univ, Evanston, IL USA Univ Notre Dame, Notre Dame, IN 46556 USA Ohio State Univ, Columbus, OH 43210 USA Princeton Univ, Princeton, NJ 08544 USA Univ Puerto Rico, Mayaguez, PR USA Purdue Univ, W Lafayette, IN 47907 USA Purdue Univ Northwest, Hammond, LA USA Rice Univ, Houston, TX USA Univ Rochester, Rochester, NY 14627 USA Rutgers State Univ, Piscataway, NJ USA Univ Tennessee, Knoxville, TN USA Texas A&M Univ, College Stn, TX USA Texas Tech Univ, Lubbock, TX 79409 USA Vanderbilt Univ, 221 Kirkland Hall, Nashville, TN 37235 USA Univ Virginia, Charlottesville, VA USA Wayne State Univ, Detroit, MI USA Univ Wisconsin, Madison, WI USA Vienna Univ Technol, Vienna, Austria Univ Estadual Campinas, Campinas, SP, Brazil Univ Fed Pelotas, Pelotas, Brazil Univ Antioquia, Medellin, Colombia Ain Shams Univ, Cairo, Egypt British Univ Egypt, Cairo, Egypt Zewail City Sci & Technol, Zewail, Egypt Univ Haute Alsace, Mulhouse, France Brandenburg Tech Univ Cottbus, Cottbus, Germany Indian Inst Technol Bhubaneswar, Bhubaneswar, Orissa, India Univ Visva Bharati, Santini Ketan, W Bengal, India Indian Inst Sci Educ & Res, Bhopal, India Inst Phys, Bhubaneswar, Orissa, India Univ Ruhuna, Matara, Sri Lanka Isfahan Univ Technol, Esfahan, Iran Yazd Univ, Yazd, Iran Islamic Azad Univ, Plasma Phys Res Ctr, Sci & Res Branch, Tehran, Iran Univ Siena, Siena, Italy Int Islamic Univ Malaysia, Kuala Lumpur, Malaysia MOSTI, Malaysian Nucl Agcy, Kajang, Malaysia Consejo Nacl Ciencia Tecnol, Mexico City, DF, Mexico Warsaw Univ Technol, Inst Elect Syst, Warsaw, Poland St Petersburg State Polytech Univ, St Petersburg, Russia Budker Inst Nucl Phys, Novosibirsk, Russia Sapienza Univ Roma, INFN, Sez Roma, Rome, Italy INFN, Scuola Normale & Sez, Pisa, Italy Riga Tech Univ, Riga, Latvia Albert Einstein Ctr Fundamental Phys, Bern, Switzerland Adiyaman Univ, Adiyaman, Turkey Istanbul Aydin Univ, Istanbul, Turkey Mersin Univ, Mersin, Turkey Cag Univ, Mersin, Turkey Piri Reis Univ, Istanbul, Turkey Gaziosmanpasa Univ, Tokat, Turkey Ozyegin Univ, Istanbul, Turkey Izmir Inst Technol, Izmir, Turkey Marmara Univ, Istanbul, Turkey Kafkas Univ, Kars, Turkey Istanbul Bilgi Univ, Istanbul, Turkey Yildiz Tech Univ, Istanbul, Turkey Hacettepe Univ, Ankara, Turkey Univ Southampton, Sch Phys & Astron, Southampton, Hants, England Inst Astrofis Canarias, San Cristobal la Laguna, Spain Utah Valley Univ, Orem, UT USA BEYKENT Univ, Istanbul, Turkey Erzincan Univ, Erzincan, Turkey Mimar Sinan Univ, Istanbul, Turkey Texas A& M Univ Qatar, Doha, Qatar Univ Estadual Paulista, Sao Paulo, Brazil Horizon Grant (European Union): 675440 National Science Center (Poland): Harmonia 2014/14/M/ST2/00428 National Science Center (Poland): Opus 2014/13/B/ST2/02543 National Science Center (Poland): 2014/15/B/ST2/03998 National Science Center (Poland): 2015/19/B/ST2/02861 National Science Center (Poland): Sonata-bis 2012/07/E/ST2/01406 Welch Foundation: C-1845
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- 2017
37. Multimodale Radiomics-Analysen zur Überlebensvorhersage bei erstdiagnostizierten Glioblastomen
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Kaiser, L., Quach, S., Zounek, A. J., Zatcepin, A., Holzgreve, A., Kirchleitner, S., Ruf, V. C., Brendel, M., Thon, N., Herms, J., Riemenschneider, M. J., Stöcklein, S., Niyazi, M., Rupprecht, R., Tonn, J. C., Bartenstein, P., Ziegler, S., von Baumgarten, L., and Albert, N. L.
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- 2024
- Full Text
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38. Comparison of 18F-GE-180 and dynamic 18F-FET PET in high grade glioma: a double-tracer pilot study
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Unterrainer, Marcus, primary, Fleischmann, D. F., additional, Diekmann, C., additional, Vomacka, L., additional, Lindner, S., additional, Vettermann, F., additional, Brendel, M., additional, Wenter, V., additional, Ertl-Wagner, B., additional, Herms, J., additional, Wetzel, C., additional, Rupprecht, R., additional, Tonn, J. C., additional, Belka, C., additional, Bartenstein, P., additional, Niyazi, M., additional, and Albert, Nathalie L., additional
- Published
- 2018
- Full Text
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39. The German Research Network for mental Disorders
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Bauer M, Banaschewski T, Heinz A, Kamp-Becker I, Meyer-Lindenberg A, Padberg F, Ma, Rapp, Rupprecht R, Frank Schneider, Tg, Schulze, and Hu, Wittchen
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Government Programs ,Translational Research, Biomedical ,Academic Medical Centers ,Biomedical Research ,Interinstitutional Relations ,Germany ,Mental Disorders ,Models, Organizational ,Humans - Abstract
Mental disorders are among the greatest medical and social challenges facing us. They can occur at all stages of life and are among the most important commonly occurring diseases. In Germany 28 % of the population suffer from a mental disorder every year, while the lifetime risk of suffering from a mental disorder is almost 50 %. Mental disorders cause great suffering for those affected and their social network. Quantitatively speaking, they can be considered to be among those diseases creating the greatest burden for society due to reduced productivity, absence from work and premature retirement. The Federal Ministry of Education and Research is funding a new research network from 2015 to 2019 with up to 35 million euros to investigate mental disorders in order to devise and develop better therapeutic measures and strategies for this population by means of basic and translational clinical research. This is the result of a competitive call for research proposals entitled research network for mental diseases. It is a nationwide network of nine consortia with up to ten psychiatric and clinical psychology partner institutions from largely university-based research facilities for adults and/or children and adolescents. Furthermore, three cross-consortia platform projects will seek to identify shared causes of diseases and new diagnostic modalities for anxiety disorders, attention deficit hyperactivity disorders (ADHS), autism, bipolar disorders, depression, schizophrenia and psychotic disorders as well as substance-related and addictive disorders. The spectrum of therapeutic approaches to be examined ranges from innovative pharmacological and psychotherapeutic treatment to novel brain stimulation procedures. In light of the enormous burden such diseases represent for society as a whole, a sustainable improvement in the financial support for those researching mental disorders seems essential. This network aims to become a nucleus for long overdue and sustained support for a German center for mental disorders.
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- 2016
40. Brain microglia in psychiatric disorders
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Mondelli, Valeria, Vernon, Anthony C, Turkheimer, Federico, Dazzan, Paola, Pariante, Carmine M, Frost, JL, Schafer, DP, Banati, RB, Newcombe, J, Gunn, RN, al., et, Tang, Y, Le, W, Estes, ML, McAllister, AK, Ransohoff, RM, Davalos, D, Grutzendler, J, Yang, G, Peferoen, LA, Vogel, DY, Ummenthum, K, Norden, DM, Trojanowski, PJ, Villanueva, E, Navarro, E, Godbout, JP, Kreisel, T, Frank, MG, Licht, T, Wachholz, S, Eßlinger, M, Plümper, J, Manitz, MP, Juckel, G, Friebe, A, Trépanier, MO, Hopperton, KE, Mizrahi, R, Mechawar, N, Bazinet, RP, Torres-Platas, SG, Cruceanu, C, Chen, GG, Turecki, G, Steiner, J, Bielau, H, Brisch, R, Schnieder, TP, Trencevska, I, Rosoklija, G, Fillman, SG, Cloonan, N, Catts, VS, Rupprecht, R, Papadopoulos, V, Rammes, G, Qiu, ZK, Li, MS, He, JL, Hannestad, J, Gallezot, JD, Schafbauer, T, Israel, I, Ohsiek, A, Al-Momani, E, Mirzaei, N, Tang, SP, Ashworth, S, Gulyás, B, Makkai, B, Kása, P, Turkheimer, FE, Rizzo, G, Bloomfield, PS, Owen, DR, Yeo, AJ, DellaGioia, N, Setiawan, E, Wilson, AA, Su, L, Faluyi, YO, Hong, YT, Haarman, BC, Lek, RF Riemersma-Van der, Groot, JC de, Berckel, BN van, Bossong, MG, Boellaard, R, Doorduin, J, Vries, EF de, Willemsen, AT, Dierckx, RA, Klein, HC, Takano, A, Arakawa, R, Ito, H, Kenk, M, Selvanathan, T, Rao, N, Selvaraj, S, Veronese, M, Coughlin, JM, Wang, Y, Ambinder, EB, Doef, TF van der, Witte, LD de, Sutterland, AL, Hafizi, S, Tseng, HH, Holmes, SE, Hinz, R, Drake, RJ, Yaqub, M, Schuitemaker, A, Edison, P, Pavese, N, Lockhart, A, Davis, B, Matthews, JC, Quarantelli, M, Laule, C, Vavasour, IM, Kolind, SH, Pasternak, O, Sochen, N, Gur, Y, Intrator, N, Assaf, Y, Andreasen, NC, Ehrhardt, JC, Swayze, VW, Supprian, T, Hofmann, E, Warmuth-Metz, M, Franzek, E, Becker, T, Pfefferbaum, A, Sullivan, EV, Hedehus, M, Moseley, M, Lim, KO, Mandl, RC, Schnack, HG, Luigjes, J, Cahn, W, Bagary, MS, Symms, MR, Barker, GJ, Mutsatsa, SH, Joyce, EM, Ron, MA, Foong, J, Maier, M, Brocklehurst, S, Miller, DH, Kubicki, M, Park, H, Westin, CF, Bouix, S, Dahlben, B, Oestreich, LK, Shenton, ME, Amato, D, Beasley, CL, Hahn, MK, Vernon, AC, Natesan, S, Modo, M, Kapur, S, Mondelli, V, Reininghaus, U, Kempton, MJ, Valmaggia, L, Baumeister, D, Lightman, SL, Pariante, CM, Danese, A, Moffitt, TE, Ambler, A, Poulton, R, Caspi, A, Akhtar, R, Ciufolini, S, Meyer, U, So, PW, Lythgoe, DJ, Cotel, MC, Lenartowicz, EM, Anacker, C, Calcia, MA, Bonsall, DR, Barichello, T, Howes, OD, Burke, NN, Fan, CY, Trang, T, McMahon, SB, Russa, F La, Bennett, DL, Püntener, U, Booth, SG, Perry, VH, Teeling, JL, Hahn, YK, Podhaizer, EM, Farris, SP, Miles, MF, Hauser, KF, Knapp, PE, Notter, T, Gschwind, T, Varga, B, Markó, K, Hádinger, N, Cattaneo, A, Ferrari, C, Uher, R, Belvederi, Murri M, Sandiego, CM, Pittman, B, Weber, MD, Sheridan, JF, Raison, CL, Rutherford, RE, Woolwine, BJ, Möller, T, Boddeke, HW, O'Connor, JC, Lawson, MA, André, C, Hinwood, M, Morandini, J, Day, TA, Walker, FR, Bard, F, Bhattacharya, A, Pae, CU, Marks, DM, Han, C, Patkar, AA, Oya, K, Kishi, T, Iwata, N, Pathology, NCA - Neuroinflamation, Molecular cell biology and Immunology, Gastroenterology and hepatology, CCA - Disease profiling, ICaR - Heartfailure and pulmonary arterial hypertension, ICaR - Ischemia and repair, NCA - Brain imaging technology, Radiology and nuclear medicine, Amsterdam Neuroscience - Brain Imaging, Otolaryngology / Head & Neck Surgery, EMGO - Quality of care, AII - Infectious diseases, CCA - Imaging, and Neurology
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0301 basic medicine ,medicine.medical_specialty ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Animals ,Humans ,Psychology ,In patient ,Psychiatry ,Biological Psychiatry ,Neuroinflammation ,Inflammation ,Microglia ,business.industry ,Macrophages ,Mental Disorders ,Brain ,Magnetic Resonance Imaging ,Psychiatry and Mental health ,030104 developmental biology ,medicine.anatomical_structure ,Psychosocial stress ,Treatment strategy ,Autopsy ,business ,Neuroscience ,030217 neurology & neurosurgery ,Stress, Psychological ,Immune activation - Abstract
SummaryThe role of immune activation in psychiatric disorders has attracted considerable attention over the past two decades, contributing to the rise of a new era for psychiatry. Microglia, the macrophages of the brain, are progressively becoming the main focus of the research in this field. In this Review, we assess the literature on microglia activation across different psychiatric disorders, including post-mortem and in-vivo studies in humans and experimental studies in animals. Although microglia activation has been noted in all types of psychiatric disorder, no association was seen with specific diagnostic categories. Furthermore, the findings from these studies highlight that not all psychiatric patients have microglial activation. Therefore, the cause of the neuroinflammation in these cohorts and its implications are unclear. We discuss psychosocial stress as one of the main factors determining microglial activation in patients with psychiatric disorders, and explore the relevance of these findings for future treatment strategies.
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- 2016
41. A meta-analysis of dose escalation of antidepressant agents in major depressive disorder
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Bartova, L., primary, Dold, M., additional, Rupprecht, R., additional, and Kasper, S., additional
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- 2017
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42. Meta-analysis of aberrant brain activity in psychopathy
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Poeppl, T., primary, Donges, M., additional, Rupprecht, R., additional, Fox, P., additional, Laird, A., additional, Bzdok, D., additional, Langguth, B., additional, and Eickhoff, S., additional
- Published
- 2017
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- View/download PDF
43. P310 Brain stimulation-induced neuroplasticity underlying therapeutic response in phantom sounds
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Poeppl, T., primary, Langguth, B., additional, Lehner, A., additional, Rupprecht, R., additional, Kreuzer, P., additional, Landgrebe, M., additional, and Schecklmann, M., additional
- Published
- 2017
- Full Text
- View/download PDF
44. Comparison of 18F-GE-180 and dynamic 18F-FET PET in high grade glioma: a double-tracer pilot study.
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Unterrainer, Marcus, Fleischmann, D. F., Diekmann, C., Vomacka, L., Lindner, S., Vettermann, F., Brendel, M., Wenter, V., Ertl-Wagner, B., Herms, J., Wetzel, C., Rupprecht, R., Tonn, J. C., Belka, C., Bartenstein, P., Niyazi, M., and Albert, Nathalie L.
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GLIOMAS ,POSITRON emission tomography ,MAGNETIC resonance imaging ,NERVOUS system tumors ,DIAGNOSTIC imaging - Abstract
Background: PET represents a valuable tool for glioma imaging. In addition to amino acid tracers such as
18 F-FET, PET targeting the 18-kDa mitochondrial translocator-protein (TSPO) is of high interest for high-grade glioma (HGG) imaging due to its upregulation in HGG cells.18 F-GE-180, a novel TSPO ligand, has shown a high target-to-background contrast in HGG. Therefore, we intra-individually compared its uptake characteristics to dynamic18 F-FET PET and contrast-enhanced MRI in patients with HGG.Methods: Twenty HGG patients (nine IDH-wildtype, 11 IDH-mutant) at initial diagnosis (n = 8) or recurrence (n = 12) were consecutively included and underwent18 F-GE-180 PET, dynamic18 F-FET PET, and MRI. The maximal tumour-to-background ratios (TBRmax ) and biological tumour volumes (BTV) were evaluated in18 F-GE-180 and18 F-FET PET. Dynamic18 F-FET PET analysis included the evaluation of minimal time-to-peak (TTPmin ). In MRI, the volume of contrast-enhancement was delineated (VOLCE ). Volumes were spatially correlated using the Sørensen-Dice coefficient.Results: The median TBRmax tended to be higher in18 F-GE-180 PET compared to18 F-FET PET [4.58 (2.33-8.95) vs 3.89 (1.56-7.15); p = 0.062] in the overall group. In subgroup analyses, IDH-wildtype gliomas showed a significantly higher median TBRmax in18 F-GE-180 PET compared to18 F-FET PET [5.45 (2.56-8.95) vs 4.06 (1.56-4.48); p = 0.008]; by contrast, no significant difference was observed in IDH-mutant gliomas [3.97 (2.33-6.81) vs 3.79 (2.01-7.15) p = 1.000]. Only 5/20 cases showed higher TBRmax in18 F-FET PET compared to18 F-GE-180 PET, all of them being IDH-mutant gliomas. No parameter in18 F-GE-180 PET correlated with TTPmin (p > 0.05 each). There was a tendency towards higher median BTVGE-180 [32.1 (0.4-236.0) ml] compared to BTVFET [19.3 (0.7-150.2) ml; p = 0.062] with a moderate spatial overlap [median Sørensen-Dice coefficient 0.55 (0.07-0.85)]. In MRI, median VOLCE [9.7 (0.1-72.5) ml] was significantly smaller than both BTVFET and BTVGE180 (p < 0.001 each), leading to a poor spatial correlation with BTVGE-180 [0.29 (0.01-0.48)] and BTVFET [0.38 (0.01-0.68)].Conclusion: PET with18 F-GE-180 and18 F-FET provides differing imaging information in HGG dependent on the IDH-mutational status, with diverging spatial overlap and vast exceedance of contrast-enhancement in MRI. Combined PET imaging might reveal new insights regarding non-invasive characterization of tumour heterogeneity and might influence patients' management. [ABSTRACT FROM AUTHOR]- Published
- 2019
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- View/download PDF
45. Dickdarmmikrobiom und Depression
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Manook, A., primary, Hiergeist, A., additional, Rupprecht, R., additional, and Baghai, T. C., additional
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- 2016
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46. Translocator Protein (TSPO) Expression in Platelets of Depressed Patients Decreases during Antidepressant Therapy
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Sarubin, N., additional, Baghai, T., additional, Lima-Ojeda, J., additional, Melchner, D., additional, Hallof-Buestrich, H., additional, Wolf, L., additional, Hilbert, S., additional, Milenkovic, V., additional, Wetzel, C., additional, Rupprecht, R., additional, and Nothdurfter, C., additional
- Published
- 2016
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47. TSPO PET with [18F]GE-180 sensitively detects focal neuroinflammation in patients with relapsing-remitting multiple sclerosis.
- Author
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Unterrainer, Marcus, Mahler, C., Vomacka, L., Lindner, S., Havla, J., Brendel, M., Böning, G., Ertl-Wagner, B., Kümpfel, T., Milenkovic, V. M., Rupprecht, R., Kerschensteiner, M., Bartenstein, P., and Albert, Nathalie L.
- Subjects
POSITRON emission tomography ,MAGNETIC resonance imaging ,MACROPHAGES ,TRANSLOCATOR proteins - Abstract
Purpose: Expression of the translocator protein (TSPO) is upregulated in activated macrophages/microglia and is considered to be a marker of neuroinflammation. We investigated the novel TSPO ligand [
18 F]GE-180 in patients with relapsing-remitting multiple sclerosis (RRMS) to determine the feasibility of [18 F]GE-180 PET imaging in RRMS patients and to assess its ability to detect active inflammatory lesions in comparison with the current gold standard, contrast-enhanced magnetic resonance imaging (MRI).Methods: Nineteen RRMS patients were prospectively included in this study. All patients underwent TSPO genotyping and were classified as high-affinity, medium-affinity or low-affinity binders (HAB/MAB/LAB). PET scans were performed after administration of 189 ± 12 MBq [18 F]GE-180, and 60-90 min summation images were used for visual analysis and assessment of standardized uptake values (SUV). The frontal nonaffected cortex served as a pseudoreference region (PRR) for evaluation of SUV ratios (SUVR). PET data were correlated with MRI signal abnormalities, i.e. T2 hyperintensity or contrast enhancement (CE). When available, previous MRI data were used to follow the temporal evolution of individual lesions.Results: Focal lesions were identified as hot spots by visual inspection. Such lesions were detected in 17 of the 19 patients and overall 89 [18 F]GE-180-positive lesions were found. TSPO genotyping revealed 11 patients with HAB status, 5 with MAB status and 3 with LAB status. There were no associations between underlying binding status (HAB, MAB and LAB) and the signal intensity in either lesions (SUVR 1.87 ± 0.43, 1.95 ± 0.48 and 1.86 ± 0.80, respectively; p = 0.280) or the PRR (SUV 0.36 ± 0.03, 0.40 ± 0.06 and 0.37 ± 0.03, respectively; p = 0.990). Of the 89 [18 F]GE-180-positive lesions, 70 showed CE on MRI, while the remainder presented as T2 lesions without CE. SUVR were significantly higher in lesions with CE than in those without (2.00 ± 0.53 vs. 1.60 ± 0.15; p = 0.001). Notably, of 19 [18 F]GE-180-positive lesions without CE, 8 previously showed CE, indicating that [18 F]GE-180 imaging may be able to detect lesional activity that is sustained beyond the blood-brain barrier breakdown.Conclusion: [18 F]GE-180 PET can detect areas of focal macrophage/microglia activation in patients with RRMS in lesions with and without CE on MRI. Therefore, [18 F]GE-180 PET imaging is a sensitive and quantitative approach to the detection of active MS lesions. It may provide information beyond contrast-enhanced MRI and is readily applicable to all patients. [18 F]GE-180 PET imaging is therefore a promising new tool for the assessment of focal inflammatory activity in MS. [ABSTRACT FROM AUTHOR]- Published
- 2018
- Full Text
- View/download PDF
48. TSPO PET for glioma imaging using the novel ligand F-GE-180: first results in patients with glioblastoma.
- Author
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Albert, Nathalie, Unterrainer, M., Fleischmann, D., Lindner, S., Vettermann, F., Brunegraf, A., Vomacka, L., Brendel, M., Wenter, V., Wetzel, C., Rupprecht, R., Tonn, J.-C., Belka, C., Bartenstein, P., and Niyazi, M.
- Subjects
TRANSLOCATOR proteins ,POSITRON emission tomography ,GLIOMAS ,DIAGNOSTIC imaging ,GLIOBLASTOMA multiforme ,PATIENTS - Abstract
Objective: The 18-kDa mitochondrial translocator protein (TSPO) was reported to be upregulated in gliomas. F-GE-180 is a novel 3rd generation TSPO receptor ligand with improved target-to-background contrast compared to previous tracers. In this pilot study, we compared PET imaging with F-GE-180 and MRI of patients with untreated and recurrent pretreated glioblastoma. Methods: Eleven patients with histologically confirmed IDH wildtype gliomas (10 glioblastomas, 1 anaplastic astrocytoma) underwent F-GE-180 PET at initial diagnosis or recurrence. The PET parameters mean background uptake (SUV), maximal tumour-to-background ratio (TBR) and PET volume using different thresholds (SUV × 1.6, 1.8 and 2.0) were evaluated in the 60-80 min p.i. summation images. The different PET volumes were compared to the contrast-enhancing tumour volume on MRI. Results: All gliomas were positive on F-GE-180 PET and were depicted with extraordinarily high tumour-to-background contrast (median SUV 0.47 (0.37-0.93), TBR 6.61 (3.88-9.07)). F-GE-180 uptake could be found even in areas without contrast enhancement on MRI, leading to significantly larger PET volumes than MRI-based volumes (median 90.5, 74.5, and 63.8 mL vs. 31.0 mL; p = 0.003, 0.004, 0.013). In percentage difference, the PET volumes were on average 179%, 135%, and 90% larger than the respective MRI volumes. The median spatial volumetric correlation (Sørensen-Dice coefficient) of PET volumes and MRI volumes prior to radiotherapy was 0.48, 0.54, and 0.58. Conclusion: F-GE-180 PET provides a remarkably high tumour-to-background contrast in untreated and pretreated glioblastoma and shows tracer uptake even beyond contrast enhancement on MRI. To what extent F-GE-180 uptake reflects the tumour extent of human gliomas and inflammatory cells remains to be evaluated in future prospective studies with guided stereotactic biopsies and correlation of histopathological results. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
49. Anticipatory anxiety in phobic postural vertigo patients – functional indicators for anxiety-related disorder
- Author
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Chrobok, A, primary, Länger, A, additional, Karch, S, additional, Keeser, D, additional, Lehmann, K, additional, Leicht, G, additional, Mulert, C, additional, Eser-Valeri, D, additional, Ertl-Wagner, B, additional, Dieterich, M, additional, Rupprecht, R, additional, and Pogarell, O, additional
- Published
- 2015
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50. Enhancing neurosteroid synthesis – Relationship to the pharmacology of translocator protein (18 kDa) (TSPO) ligands and benzodiazepines
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Wolf, L, primary, Bauer, A, additional, Melchner, D, additional, Hallof-Buestrich, H, additional, Stoertebecker, P, additional, Haen, E, additional, Kreutz, M, additional, Sarubin, N, additional, Milenkovic, V, additional, Wetzel, C, additional, Rupprecht, R, additional, and Nothdurfter, C, additional
- Published
- 2015
- Full Text
- View/download PDF
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