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5. Geometrically frustrated, mechanical metamaterial membranes: Large-scale stress accumulation and size-selective assembly

Author

Wang, Micheal, Roy, Sourav, Santangelo, Christian D., and Grason, Gregory M.

Subjects
Condensed Matter - Soft Condensed Matter, Condensed Matter - Materials Science
Abstract

We study the effect of geometric frustration on dilational mechanical metamaterial membranes. While shape frustrated elastic plates can only accommodate non-zero Gaussian curvature up to size scales that ultimately vanish with their elastic thickness, we show that frustrated {\it metamembranes} accumulate hyperbolic curvatures up to mesoscopic length scales that are ultimately independent of the size of their microscopic constituents. A continuum elastic theory and discrete numerical model describe the size-dependent shape and internal stresses of axisymmetric, trumpet-like frustrated metamembranes, revealing a non-trivial crossover to a much weaker power-law growth in elastic strain energy with size than in frustrated elastic membranes. We study a consequence of this for the self-limiting assembly thermodynamics of frustrated trumpets, showing a several-fold increase the size range of self-limitation of metamembranes relative to elastic membranes., Comment: 6 pages, 3 figures, supplementary text appendices

Published
2024

7. Glycolytic lactate in diabetic kidney disease.

Author

Darshi, Manjula, Kugathasan, Luxcia, Maity, Soumya, Sridhar, Vikas, Fernandez, Roman, Limonte, Christine, Grajeda, Brian, Saliba, Afaf, Zhang, Guanshi, Drel, Viktor, Kim, Jiwan, Montellano, Richard, Tumova, Jana, Montemayor, Daniel, Wang, Zhu, Liu, Jian-Jun, Wang, Jiexun, Perkins, Bruce, Lytvyn, Yuliya, Natarajan, Loki, Lim, Su, Feldman, Harold, Toto, Robert, Sedor, John, Patel, Jiten, Waikar, Sushrut, Brown, Julia, Osman, Yahya, He, Jiang, Chen, Jing, Reeves, W, de Boer, Ian, Roy, Sourav, Vallon, Volker, Hallan, Stein, Gelfond, Jonathan, Cherney, David, and Sharma, Kumar

Subjects
Chronic kidney disease, Diabetes, Mitochondria, Nephrology, Humans, Diabetic Nephropathies, Animals, Mice, Lactic Acid, Female, Male, Glycolysis, Middle Aged, Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1, Mitochondria, Adult, Glomerular Filtration Rate, Aged, Kidney Tubules, Proximal, Glucose, Oxidative Phosphorylation, Biomarkers, Sodium-Glucose Transporter 2, Sodium-Glucose Transporter 2 Inhibitors
Abstract

Lactate elevation is a well-characterized biomarker of mitochondrial dysfunction, but its role in diabetic kidney disease (DKD) is not well defined. Urine lactate was measured in patients with type 2 diabetes (T2D) in 3 cohorts (HUNT3, SMART2D, CRIC). Urine and plasma lactate were measured during euglycemic and hyperglycemic clamps in participants with type 1 diabetes (T1D). Patients in the HUNT3 cohort with DKD had elevated urine lactate levels compared with age- and sex-matched controls. In patients in the SMART2D and CRIC cohorts, the third tertile of urine lactate/creatinine was associated with more rapid estimated glomerular filtration rate decline, relative to first tertile. Patients with T1D demonstrated a strong association between glucose and lactate in both plasma and urine. Glucose-stimulated lactate likely derives in part from proximal tubular cells, since lactate production was attenuated with sodium-glucose cotransporter-2 (SGLT2) inhibition in kidney sections and in SGLT2-deficient mice. Several glycolytic genes were elevated in human diabetic proximal tubules. Lactate levels above 2.5 mM potently inhibited mitochondrial oxidative phosphorylation in human proximal tubule (HK2) cells. We conclude that increased lactate production under diabetic conditions can contribute to mitochondrial dysfunction and become a feed-forward component to DKD pathogenesis.

Published
2024

8. VLSI Architectures of Forward Kinematic Processor for Robotics Applications

Author

Roy, Sourav, Paul, Subhadeep, and Maiti, Tapas Kumar

Subjects
Computer Science - Robotics
Abstract

This paper aims to get a comprehensive review of current-day robotic computation technologies at VLSI architecture level. We studied several repots in the domain of robotic processor architecture. In this work, we focused on the forward kinematics architectures which consider CORDIC algorithms, VLSI circuits of WE DSP16 chip, parallel processing and pipelined architecture, and lookup table formula and FPGA processor. This study gives us an understanding of different implementation methods for forward kinematics. Our goal is to develop a forward kinematics processor with FPGA for real-time applications, requires a fast response time and low latency of these devices, useful for industrial automation where the processing speed plays a great role., Comment: 8 pages, 22 figures

Published
2024

14. Curvature screening in draped mechanical metamaterial sheet

Author

Roy, Sourav and Santangelo, C. D.

Subjects
Condensed Matter - Soft Condensed Matter, Physics - Applied Physics
Abstract

We develop a framework to understand the mechanics of metamaterial sheets on curved surfaces. Here we have constructed a continuum elastic theory of mechanical metamaterials by introducing an auxiliary, scalar gauge-like field that absorbs the strain along the soft mode and projects out the stiff ones. We propose a general form of the elastic energy of a mechanism based metamaterial sheet and specialize to the cases of dilational metamaterials and shear metamaterials conforming to positively and negatively curved substrates in the F\"{o}ppl-Von K\'{a}rm\'{a}n limit of small strains. We perform numerical simulations of these systems and obtain good agreement with our analytical predictions. This work provides a framework that can be easily extended to explore non-linear soft modes in metamaterial elasticity in future., Comment: 9 pages, 5 figures

Published
2023
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16. Time delays shape the eco-evolutionary dynamics of cooperation.

Author

Roy, Sourav, Nag Chowdhury, Sayantan, Kundu, Srilena, Sar, Gourab, Banerjee, Jeet, Rakshit, Biswambhar, Mali, Prakash, Perc, Matjaž, and Ghosh, Dibakar

Subjects
Humans, Altruism, Biological Evolution, Decision Making, Lens, Crystalline, Lenses
Abstract

We study the intricate interplay between ecological and evolutionary processes through the lens of the prisoners dilemma game. But while previous studies on cooperation amongst selfish individuals often assume instantaneous interactions, we take into consideration delays to investigate how these might affect the causes underlying prosocial behavior. Through analytical calculations and numerical simulations, we demonstrate that delays can lead to oscillations, and by incorporating also the ecological variable of altruistic free space and the evolutionary strategy of punishment, we explore how these factors impact population and community dynamics. Depending on the parameter values and the initial fraction of each strategy, the studied eco-evolutionary model can mimic a cyclic dominance system and even exhibit chaotic behavior, thereby highlighting the importance of complex dynamics for the effective management and conservation of ecological communities. Our research thus contributes to the broader understanding of group decision-making and the emergence of moral behavior in multidimensional social systems.

Published
2023

18. Timed material self-assembly controlled by circadian clock proteins

Author

Leech, Gregor, Melcher, Lauren, Chiu, Michelle, Nugent, Maya, Burton, Lily, Kang, Janet, Kim, Soo Ji, Roy, Sourav, Farhadi, Leila, Ross, Jennifer L., Das, Moumita, Rust, Michael J., and Robertson-Anderson, Rae M.

Subjects
Condensed Matter - Soft Condensed Matter, Physics - Biological Physics
Abstract

Active biological molecules present a powerful, yet largely untapped, opportunity to impart autonomous regulation to materials. Because these systems can function robustly to regulate when and where chemical reactions occur, they have the ability to bring complex, life-like behavior to synthetic materials. Here, we achieve this design feat by using functionalized circadian clock proteins, KaiB and KaiC, to engineer time-dependent crosslinking of colloids. The resulting material self-assembles with programmable kinetics, producing macroscopic changes in material properties, via molecular assembly of KaiB-KaiC complexes. We show that colloid crosslinking depends strictly on the phosphorylation state of KaiC, with kinetics that are synced with KaiB-KaiC complexing. Our microscopic image analyses and computational models indicate that the stability of colloidal super-structures depends sensitively on the number of Kai complexes per colloid connection. Consistent with our model predictions, a high concentration stabilizes the material against dissolution after a robust self-assembly phase, while a low concentration allows circadian oscillation of material structure. This work introduces the concept of harnessing biological timers to control synthetic materials; and, more generally, opens the door to using protein-based reaction networks to endow synthetic systems with life-like functional properties., Comment: 5 figures + SI

Published
2023

20. BLOOM: A 176B-Parameter Open-Access Multilingual Language Model

Author

Workshop, BigScience, Scao, Teven Le, Fan, Angela, Akiki, Christopher, Pavlick, Ellie, Ilić, Suzana, Hesslow, Daniel, Castagné, Roman, Luccioni, Alexandra Sasha, Yvon, François, Gallé, Matthias, Tow, Jonathan, Rush, Alexander M., Biderman, Stella, Webson, Albert, Ammanamanchi, Pawan Sasanka, Wang, Thomas, Sagot, Benoît, Muennighoff, Niklas, del Moral, Albert Villanova, Ruwase, Olatunji, Bawden, Rachel, Bekman, Stas, McMillan-Major, Angelina, Beltagy, Iz, Nguyen, Huu, Saulnier, Lucile, Tan, Samson, Suarez, Pedro Ortiz, Sanh, Victor, Laurençon, Hugo, Jernite, Yacine, Launay, Julien, Mitchell, Margaret, Raffel, Colin, Gokaslan, Aaron, Simhi, Adi, Soroa, Aitor, Aji, Alham Fikri, Alfassy, Amit, Rogers, Anna, Nitzav, Ariel Kreisberg, Xu, Canwen, Mou, Chenghao, Emezue, Chris, Klamm, Christopher, Leong, Colin, van Strien, Daniel, Adelani, David Ifeoluwa, Radev, Dragomir, Ponferrada, Eduardo González, Levkovizh, Efrat, Kim, Ethan, Natan, Eyal Bar, De Toni, Francesco, Dupont, Gérard, Kruszewski, Germán, Pistilli, Giada, Elsahar, Hady, Benyamina, Hamza, Tran, Hieu, Yu, Ian, Abdulmumin, Idris, Johnson, Isaac, Gonzalez-Dios, Itziar, de la Rosa, Javier, Chim, Jenny, Dodge, Jesse, Zhu, Jian, Chang, Jonathan, Frohberg, Jörg, Tobing, Joseph, Bhattacharjee, Joydeep, Almubarak, Khalid, Chen, Kimbo, Lo, Kyle, Von Werra, Leandro, Weber, Leon, Phan, Long, allal, Loubna Ben, Tanguy, Ludovic, Dey, Manan, Muñoz, Manuel Romero, Masoud, Maraim, Grandury, María, Šaško, Mario, Huang, Max, Coavoux, Maximin, Singh, Mayank, Jiang, Mike Tian-Jian, Vu, Minh Chien, Jauhar, Mohammad A., Ghaleb, Mustafa, Subramani, Nishant, Kassner, Nora, Khamis, Nurulaqilla, Nguyen, Olivier, Espejel, Omar, de Gibert, Ona, Villegas, Paulo, Henderson, Peter, Colombo, Pierre, Amuok, Priscilla, Lhoest, Quentin, Harliman, Rheza, Bommasani, Rishi, López, Roberto Luis, Ribeiro, Rui, Osei, Salomey, Pyysalo, Sampo, Nagel, Sebastian, Bose, Shamik, Muhammad, Shamsuddeen Hassan, Sharma, Shanya, Longpre, Shayne, Nikpoor, Somaieh, Silberberg, Stanislav, Pai, Suhas, Zink, Sydney, Torrent, Tiago Timponi, Schick, Timo, Thrush, Tristan, Danchev, Valentin, Nikoulina, Vassilina, Laippala, Veronika, Lepercq, Violette, Prabhu, Vrinda, Alyafeai, Zaid, Talat, Zeerak, Raja, Arun, Heinzerling, Benjamin, Si, Chenglei, Taşar, Davut Emre, Salesky, Elizabeth, Mielke, Sabrina J., Lee, Wilson Y., Sharma, Abheesht, Santilli, Andrea, Chaffin, Antoine, Stiegler, Arnaud, Datta, Debajyoti, Szczechla, Eliza, Chhablani, Gunjan, Wang, Han, Pandey, Harshit, Strobelt, Hendrik, Fries, Jason Alan, Rozen, Jos, Gao, Leo, Sutawika, Lintang, Bari, M Saiful, Al-shaibani, Maged S., Manica, Matteo, Nayak, Nihal, Teehan, Ryan, Albanie, Samuel, Shen, Sheng, Ben-David, Srulik, Bach, Stephen H., Kim, Taewoon, Bers, Tali, Fevry, Thibault, Neeraj, Trishala, Thakker, Urmish, Raunak, Vikas, Tang, Xiangru, Yong, Zheng-Xin, Sun, Zhiqing, Brody, Shaked, Uri, Yallow, Tojarieh, Hadar, Roberts, Adam, Chung, Hyung Won, Tae, Jaesung, Phang, Jason, Press, Ofir, Li, Conglong, Narayanan, Deepak, Bourfoune, Hatim, Casper, Jared, Rasley, Jeff, Ryabinin, Max, Mishra, Mayank, Zhang, Minjia, Shoeybi, Mohammad, Peyrounette, Myriam, Patry, Nicolas, Tazi, Nouamane, Sanseviero, Omar, von Platen, Patrick, Cornette, Pierre, Lavallée, Pierre François, Lacroix, Rémi, Rajbhandari, Samyam, Gandhi, Sanchit, Smith, Shaden, Requena, Stéphane, Patil, Suraj, Dettmers, Tim, Baruwa, Ahmed, Singh, Amanpreet, Cheveleva, Anastasia, Ligozat, Anne-Laure, Subramonian, Arjun, Névéol, Aurélie, Lovering, Charles, Garrette, Dan, Tunuguntla, Deepak, Reiter, Ehud, Taktasheva, Ekaterina, Voloshina, Ekaterina, Bogdanov, Eli, Winata, Genta Indra, Schoelkopf, Hailey, Kalo, Jan-Christoph, Novikova, Jekaterina, Forde, Jessica Zosa, Clive, Jordan, Kasai, Jungo, Kawamura, Ken, Hazan, Liam, Carpuat, Marine, Clinciu, Miruna, Kim, Najoung, Cheng, Newton, Serikov, Oleg, Antverg, Omer, van der Wal, Oskar, Zhang, Rui, Zhang, Ruochen, Gehrmann, Sebastian, Mirkin, Shachar, Pais, Shani, Shavrina, Tatiana, Scialom, Thomas, Yun, Tian, Limisiewicz, Tomasz, Rieser, Verena, Protasov, Vitaly, Mikhailov, Vladislav, Pruksachatkun, Yada, Belinkov, Yonatan, Bamberger, Zachary, Kasner, Zdeněk, Rueda, Alice, Pestana, Amanda, Feizpour, Amir, Khan, Ammar, Faranak, Amy, Santos, Ana, Hevia, Anthony, Unldreaj, Antigona, Aghagol, Arash, Abdollahi, Arezoo, Tammour, Aycha, HajiHosseini, Azadeh, Behroozi, Bahareh, Ajibade, Benjamin, Saxena, Bharat, Ferrandis, Carlos Muñoz, McDuff, Daniel, Contractor, Danish, Lansky, David, David, Davis, Kiela, Douwe, Nguyen, Duong A., Tan, Edward, Baylor, Emi, Ozoani, Ezinwanne, Mirza, Fatima, Ononiwu, Frankline, Rezanejad, Habib, Jones, Hessie, Bhattacharya, Indrani, Solaiman, Irene, Sedenko, Irina, Nejadgholi, Isar, Passmore, Jesse, Seltzer, Josh, Sanz, Julio Bonis, Dutra, Livia, Samagaio, Mairon, Elbadri, Maraim, Mieskes, Margot, Gerchick, Marissa, Akinlolu, Martha, McKenna, Michael, Qiu, Mike, Ghauri, Muhammed, Burynok, Mykola, Abrar, Nafis, Rajani, Nazneen, Elkott, Nour, Fahmy, Nour, Samuel, Olanrewaju, An, Ran, Kromann, Rasmus, Hao, Ryan, Alizadeh, Samira, Shubber, Sarmad, Wang, Silas, Roy, Sourav, Viguier, Sylvain, Le, Thanh, Oyebade, Tobi, Le, Trieu, Yang, Yoyo, Nguyen, Zach, Kashyap, Abhinav Ramesh, Palasciano, Alfredo, Callahan, Alison, Shukla, Anima, Miranda-Escalada, Antonio, Singh, Ayush, Beilharz, Benjamin, Wang, Bo, Brito, Caio, Zhou, Chenxi, Jain, Chirag, Xu, Chuxin, Fourrier, Clémentine, Periñán, Daniel León, Molano, Daniel, Yu, Dian, Manjavacas, Enrique, Barth, Fabio, Fuhrimann, Florian, Altay, Gabriel, Bayrak, Giyaseddin, Burns, Gully, Vrabec, Helena U., Bello, Imane, Dash, Ishani, Kang, Jihyun, Giorgi, John, Golde, Jonas, Posada, Jose David, Sivaraman, Karthik Rangasai, Bulchandani, Lokesh, Liu, Lu, Shinzato, Luisa, de Bykhovetz, Madeleine Hahn, Takeuchi, Maiko, Pàmies, Marc, Castillo, Maria A, Nezhurina, Marianna, Sänger, Mario, Samwald, Matthias, Cullan, Michael, Weinberg, Michael, De Wolf, Michiel, Mihaljcic, Mina, Liu, Minna, Freidank, Moritz, Kang, Myungsun, Seelam, Natasha, Dahlberg, Nathan, Broad, Nicholas Michio, Muellner, Nikolaus, Fung, Pascale, Haller, Patrick, Chandrasekhar, Ramya, Eisenberg, Renata, Martin, Robert, Canalli, Rodrigo, Su, Rosaline, Su, Ruisi, Cahyawijaya, Samuel, Garda, Samuele, Deshmukh, Shlok S, Mishra, Shubhanshu, Kiblawi, Sid, Ott, Simon, Sang-aroonsiri, Sinee, Kumar, Srishti, Schweter, Stefan, Bharati, Sushil, Laud, Tanmay, Gigant, Théo, Kainuma, Tomoya, Kusa, Wojciech, Labrak, Yanis, Bajaj, Yash Shailesh, Venkatraman, Yash, Xu, Yifan, Xu, Yingxin, Xu, Yu, Tan, Zhe, Xie, Zhongli, Ye, Zifan, Bras, Mathilde, Belkada, Younes, and Wolf, Thomas

Subjects
Computer Science - Computation and Language
Abstract

Large language models (LLMs) have been shown to be able to perform new tasks based on a few demonstrations or natural language instructions. While these capabilities have led to widespread adoption, most LLMs are developed by resource-rich organizations and are frequently kept from the public. As a step towards democratizing this powerful technology, we present BLOOM, a 176B-parameter open-access language model designed and built thanks to a collaboration of hundreds of researchers. BLOOM is a decoder-only Transformer language model that was trained on the ROOTS corpus, a dataset comprising hundreds of sources in 46 natural and 13 programming languages (59 in total). We find that BLOOM achieves competitive performance on a wide variety of benchmarks, with stronger results after undergoing multitask prompted finetuning. To facilitate future research and applications using LLMs, we publicly release our models and code under the Responsible AI License.

Published
2022

21. Cartilage Segmentation from MRI Images Towards Prediction of Osteoarthritis

Author

Das, Puja, Bhaumik, Rabin, Dey Roy, Sourav, Nath, Satyabrata, Kanti Bhowmik, Mrinal, Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Prates, Raquel Oliveira, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Kaur, Harkeerat, editor, Jakhetiya, Vinit, editor, Goyal, Puneet, editor, Khanna, Pritee, editor, Raman, Balasubramanian, editor, and Kumar, Sanjeev, editor

Published
2024
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24. Diversifying the Genomic Data Science Research Community

Author

Network, The Genomic Data Science Community, Alcazar, Rosa, Alvarez, Maria, Arnold, Rachel, Ayalew, Mentewab, Best, Lyle G., Campbell, Michael C., Chowdhury, Kamal, Cox, Katherine E. L., Daulton, Christina, Deng, Youping, Easter, Carla, Fuller, Karla, Hakim, Shazia Tabassum, Hoffman, Ava M., Kucher, Natalie, Lee, Andrew, Lee, Joslynn, Leek, Jeffrey T., Meller, Robert, Méndez, Loyda B., Méndez-González, Miguel P., Mosher, Stephen, Nishiguchi, Michele, Pratap, Siddharth, Rolle, Tiffany, Roy, Sourav, Saidi, Rachel, Schatz, Michael C., Sen, Shurjo, Sniezek, James, Martinez, Edu Suarez, Tan, Frederick, Vessio, Jennifer, Watson, Karriem, Westbroek, Wendy, Wilcox, Joseph, and Xie, Xianfa

Subjects
Quantitative Biology - Other Quantitative Biology, Computer Science - Computers and Society
Abstract

Over the last 20 years, there has been an explosion of genomic data collected for disease association, functional analyses, and other large-scale discoveries. At the same time, there have been revolutions in cloud computing that enable computational and data science research, while making data accessible to anyone with a web browser and an internet connection. However, students at institutions with limited resources have received relatively little exposure to curricula or professional development opportunities that lead to careers in genomic data science. To broaden participation in genomics research, the scientific community needs to support students, faculty, and administrators at Underserved Institutions (UIs) including Community Colleges, Historically Black Colleges and Universities, Hispanic-Serving Institutions, and Tribal Colleges and Universities in taking advantage of these tools in local educational and research programs. We have formed the Genomic Data Science Community Network (http://www.gdscn.org/) to identify opportunities and support broadening access to cloud-enabled genomic data science. Here, we provide a summary of the priorities for faculty members at UIs, as well as administrators, funders, and R1 researchers to consider as we create a more diverse genomic data science community., Comment: 42 pages, 3 figures

Published
2022

30. Eco-evolutionary dynamics of multigames with mutations.

Author

Roy, Sourav, Nag Chowdhury, Sayantan, Mali, Prakash Chandra, Perc, Matjaž, and Ghosh, Dibakar

Subjects
Humans, Cooperative Behavior, Mutation, Game Theory, Biological Evolution, Prisoner Dilemma, General Science & Technology
Abstract

Most environments favor defection over cooperation due to natural selection. Nonetheless, the emergence of cooperation is omnipresent in many biological, social, and economic systems, quite contrary to the well-celebrated Darwinian theory of evolution. Much research has been devoted to better understanding how and why cooperation persists among self-interested individuals despite their competition for limited resources. Here we go beyond a single social dilemma since individuals usually encounter various social challenges. In particular, we propose and study a mathematical model incorporating both the prisoner's dilemma and the snowdrift game. We further extend this model by considering ecological signatures like mutation and selfless one-sided contribution of altruist free space. The nonlinear evolutionary dynamics that results from these upgrades offer a broader range of equilibrium outcomes, and it also often favors cooperation over defection. With the help of analytical and numerical calculations, our theoretical model sheds light on the mechanisms that maintain biodiversity, and it helps to explain the evolution of social order in human societies.

Published
2022

33. Domain Adapted Few-Shot Learning for Breast Histopathological Image Classification

Author

Mohanta, Anindita, Dey Roy, Sourav, Nath, Niharika, Bhowmik, Mrinal Kanti, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Maji, Pradipta, editor, Huang, Tingwen, editor, Pal, Nikhil R., editor, Chaudhury, Santanu, editor, and De, Rajat K., editor

Published
2023
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41. Schwarzschild de Sitter and extremal surfaces

Author

Fernandes, Karan, Kolekar, Kedar S., Narayan, K., and Roy, Sourav

Subjects
High Energy Physics - Theory
Abstract

We study extremal surfaces in the Schwarzschild de Sitter spacetime with real mass parameter. We find codim-2 timelike extremal surfaces stretching between the future and past boundaries that pass through the vicinity of the cosmological horizon in a certain limit. These are analogous to the surfaces in arXiv:1711.01107 [hep-th]. We also find spacelike surfaces that never reach the future/past boundaries but stretch indefinitely through the extended Penrose diagram, passing through the vicinity of the cosmological and Schwarzschild horizons in a certain limit. Further, these exhibit interesting structure for de Sitter space (zero mass) as well as in the extremal, or Nariai, limit., Comment: Latex, 25pgs incl. appendices, 4 eps figs; v2: minor clarifications, references added; v3: minor corrections; v4: 30pgs, comments section added, matches version to be published

Published
2019
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