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Your search keyword '"Roth, W. Kurt"' showing total 4 results
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4 results on '"Roth, W. Kurt"'

1. Implementation of an HIV-1 Triple-Target NAT Assay in the Routine Screening at Three German Red Cross Blood Centres

Author

De Zolt, Silke, primary, Thermann, Rolf, additional, Bangsow, Thorsten, additional, Pichl, Lutz, additional, Müller, Benjamin, additional, Jork, Christine, additional, Weber-Schehl, Marijke, additional, Hedges, Doris, additional, Schupp, Ingo, additional, Unverzagt, Patrick, additional, de Rue, Katrin, additional, and Roth, W. Kurt, additional

Published
2016
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2. Erratum to: Next-generation sequencing reveals novel differentially regulated mRNAs, lncRNAs, miRNAs, sdRNAs and a piRNA in pancreatic cancer

Author

Müller, Sören, primary, Raulefs, Susanne, additional, Bruns, Philipp, additional, Afonso-Grunz, Fabian, additional, Plötner, Anne, additional, Thermann, Rolf, additional, Jäger, Carsten, additional, Schlitter, Anna Melissa, additional, Kong, Bo, additional, Regel, Ivonne, additional, Roth, W Kurt, additional, Rotter, Björn, additional, Hoffmeier, Klaus, additional, Kahl, Günter, additional, Koch, Ina, additional, Theis, Fabian J, additional, Kleeff, Jörg, additional, Winter, Peter, additional, and Michalski, Christoph W, additional

Published
2015
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3. Next-generation sequencing reveals novel differentially regulated mRNAs, lncRNAs, miRNAs, sdRNAs and a piRNA in pancreatic cancer

Author

Müller, Sören, primary, Raulefs, Susanne, additional, Bruns, Philipp, additional, Afonso-Grunz, Fabian, additional, Plötner, Anne, additional, Thermann, Rolf, additional, Jäger, Carsten, additional, Schlitter, Anna Melissa, additional, Kong, Bo, additional, Regel, Ivonne, additional, Roth, W Kurt, additional, Rotter, Björn, additional, Hoffmeier, Klaus, additional, Kahl, Günter, additional, Koch, Ina, additional, Theis, Fabian J, additional, Kleeff, Jörg, additional, Winter, Peter, additional, and Michalski, Christoph W, additional

Published
2015
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4. Implementation of an HIV-1 Triple-Target NAT Assay in the Routine Screening at Three German Red Cross Blood Centres.

Author

Zolt SD, Thermann R, Bangsow T, Pichl L, Müller B, Jork C, Weber-Schehl M, Hedges D, Schupp I, Unverzagt P, de Rue K, and Roth WK

Abstract

Background: Blood product safety was significantly improved by the introduction of NAT testing in the late 1990s, resulting in a strong decrease of transfusion-transmitted infections (TTIs). Due to the occurrence of HIV-1 NAT test failures as a consequence of mismatch mutations in the amplicon regions of mono-target NAT assays, the Paul Ehrlich Institute mandated the implementation of multi-target NAT assays for HIV-1 in 2014. Commercial suppliers mostly developed dual-target NAT assays, with only one implementing a triple-target NAT assay., Methods: The HIV-1 triple-target NAT assay v3 (GFE Blut) was tested on mutated specimens and synthetic DNA bearing mutations that resulted in sample underquantification or false-negative test results. In addition, data from 2 years routine testing at three German Red Cross Blood centres were analysed., Results: The HIV-1 triple-target PCR could compensate for all mutations tested and could compensate the loss of one amplicon without a significant loss of sensitivity. Data from 2 years routine testing showed a solid performance., Conclusion: The HIV-1 triple-target v3 assay (GFE Blut) can compensate mutations in target sequences better than a dual-target assay and is applicable to high-throughput screening, thus increasing blood product safety.

Published
2016
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