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8. Ethnicity and deprivation negatively impact the access to disease-modifying therapy for relapsing-remitting multiple sclerosis: a retrospective, single-centre study

Author

Das, Joyutpal, primary, Mallawaarachchi, Gagana, additional, Grimshaw, Jack, additional, Jackson, Thomas, additional, Talbot, Paul, additional, Sharaf, Nazar, additional, Kalatha, Thaleia, additional, Lord, Lindsay, additional, Pace, Adrian, additional, Mihalova, Tatiana, additional, Heal, Calvin, additional, and Rog, David, additional

Published
2024
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9. Comparison of switching to 6-week dosing of natalizumab versus continuing with 4-week dosing in patients with relapsing-remitting multiple sclerosis (NOVA): a randomised, controlled, open-label, phase 3b trial

Author

van der Walt, Anneke, Dwyer, Christopher, Buzzard, Katherine, Spies, Judith, Parratt, John, van Pesch, Vincent, Willekens, Barbara, Perrotta, Gaetano, Bartholomé, Emmanuel, Grand'Maison, Francois, Jacques, Francois, Giacomini, Paul, Vosoughi, Reza, Girard, Jean-Marc, de Seze, Jerome, Lebrun Frenay, Christine, Ruet, Aurelie, Laplaud, David-Axel, Reifschneider, Gerd, Wagner, Bert, Rauer, Sebastian, Pul, Refik, Seipelt, Maria, Berthele, Achim, Klotz, Luisa, Kallmann, Boris-Alexander, Paul, Friedemann, Achiron, Anat, Lus, Giacomo, Centonze, Diego, Patti, Francesco, Grimaldi, Luigi, Hupperts, Raymond, Frequin, Stephan, Fermont, Jiske, Madueno, Sara Eichau, Alonso Torres, Ana Maria, Costa-Frossard França, Lucienne, Meca-Lallana, Jose Eustasio, Ruiz, Luis Brieva, Pearson, Owen, Rog, David, Evangelou, Nikolaos, Ismail, Azza, Lathi, Ellen, Fox, Edward, Leist, Thomas, Sloane, Jacob, Wu, Gregory, Khatri, Bhupendra, Steingo, Brian, Thrower, Ben, Gudesblatt, Mark, Calkwood, Jonathan, Bandari, Daniel, Scagnelli, John, Laganke, Christopher, Robertson, Derrick, Kipp, Lucas, Belkin, Martin, Cohan, Stanley, Goldstick, Lawrence, Courtney, Ardith, Vargas, Wendy, Sylvester, Andrew, Srinivasan, Jayshri, Kannan, Meena, Picone, Maryann, English, Jeffrey, Napoli, Salvatore, Balabanov, Roumen, Zaydan, Islam, Nicholas, Jacqueline, Kaplan, Jeffrey, Lublin, Fred, Riser, Emily, Miller, Tamara, Alvarez, Enrique, Wray, Sibyl, Gross, Jeffrey, Pawate, Siddharama, Hersh, Carrie, McCarthy, Lucas, Crayton, Heidi, Graves, Jennifer, Foley, John F, Defer, Gilles, Ryerson, Lana Zhovtis, Cohen, Jeffrey A, Arnold, Douglas L, Butzkueven, Helmut, Cutter, Gary, Giovannoni, Gavin, Killestein, Joep, Wiendl, Heinz, Smirnakis, Karen, Xiao, Shan, Kong, George, Kuhelj, Robert, and Campbell, Nolan

Published
2022
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12. Safety and efficacy of bexarotene in patients with relapsing-remitting multiple sclerosis (CCMR One): a randomised, double-blind, placebo-controlled, parallel-group, phase 2a study

Author

Brown, J William L, Cunniffe, Nick G, Prados, Ferran, Kanber, Baris, Jones, Joanne L, Needham, Edward, Georgieva, Zoya, Rog, David, Pearson, Owen R, Overell, James, MacManus, David, Samson, Rebecca S, Stutters, Jonathan, ffrench-Constant, Charles, Gandini Wheeler-Kingshott, Claudia A M, Moran, Carla, Flynn, Paul D, Michell, Andrew W, Franklin, Robin J M, Chandran, Siddharthan, Altmann, Daniel R, Chard, Declan T, Connick, Peter, and Coles, Alasdair J

Published
2021
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19. Delays in Multiple Sclerosis diagnosis (DIMES): protocol for a multicentre, observational study of multiple sclerosis diagnostic pathways in the United Kingdom and Republic of Ireland.

Author

Kuri, Ashvin, Henshall, David E., Chaudhry, Daoud, Ooi, Setthasorn Zhi Yang, Zhang, Qiqi, Mathews, Joela, Thomson, Alison, Rog, David, Hobart, Jeremy, and Dobson, Ruth

Subjects
MULTIPLE sclerosis, DIME, YOUNG adults, THERAPEUTICS, SCIENTIFIC observation
Abstract

Background: Multiple sclerosis (MS) is a leading cause of non-traumatic disability in young adults. Accumulating evidence indicates early diagnosis and early treatment improves long-term outcomes. However, the MS diagnostic pathway is increasingly complex, and delays may occur at several stages. Factors causing delays remain understudied. We aim to quantify the time taken for MS to be diagnosed, and characterise the diagnostic pathway and initial care provided, in the United Kingdom (UK) and Republic of Ireland (ROI). Methods: Delays In MultiplE Sclerosis diagnosis (DIMES) in the UK and ROI is a multicentre, observational, retrospective study that will be conducted via the Neurology and Neurosurgery Interest Group (NANSIG) collaborative network. Any hospital in the UK and ROI providing an MS diagnostic service is eligible to participate. Data on consecutive individuals newly diagnosed with MS between 1st July 2022 and 31st December 2022 will be collected. The primary outcomes are 1) time from symptoms/signs prompting referral to neurology, to MS diagnosis; and 2) time from referral to neurology for suspected MS, to MS diagnosis. Secondary outcomes include: MS symptoms, referring specialties, investigations performed, neurology appointments, functional status, use of disease modifying treatments, and support at diagnosis including physical activity, and follow up. Demographic characteristics of people newly diagnosed with MS will be summarised, adherence to quality standards summarised as percentages, and time-to-event variables presented with survival curves. Multivariable models will be used to investigate the association of demographic and clinical factors with time to MS diagnosis, as defined in our primary outcomes. Discussion: DIMES aims to be the largest multicentre study of the MS diagnostic pathway in the UK and ROI. The proposed data collection provides insights that cannot be provided from contemporary registries, and the findings will inform approaches to MS services nationally in the future. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Natalizumab treatment shows low cumulative probabilities of confirmed disability worsening to EDSS milestones in the long-term setting

Author

Correale, Jorge, Caride, Alejandro, Deri, Norma H., Ballario, Carlos, Broadley, Simon, Kneebone, Chris, Barnett, Michael, Pollard, John, Hodgkinson, Suzanne, Kermode, Allan, Macdonell, Richard, King, John, Butzkueven, Helmut, Lechner-Scott, Jeannette, Saines, Noel, Slee, Mark, Plummer, Chris, Willekens, Barbara, Vanopdenbosch, Ludo, Belachew, Shibeshih, Phan-Ba, Rémy, Delvaux, Valérie, Bissay, Veronique, Debruyne, Jan, Decoo, Danny, Crols, Roeland, Symons, Anoek, Nagels, Guy, Van Pesch, Vincent, Sindic, Christian, Dubois, Benedicte, Medaer, Robert, D'Hooghe, Marie, Guillaume, Daniel, De Smet, Eric, Seeldrayers, Pierrette, Lysandropoulos, Andreas, Vokaer, Mathieu, Geens, Karine, Willems, Christina, Denayer, Pierre, Bureau, Michel, Retif, Cecile, Dupuis, Michel, Bouquiaux, Olivier, Vanderdonckt, Patrick, van Landegem, William, Caekebeke, Jo, Van Ingelghem, Erwin, Peeters, Katelijne, Gerard, Pascale, de Noordhout, Alain Maertens, Desfontaines, Philippe, Urbain, Etienne, Declercq, Inge, Van Wijmeersch, Bart, Vanroose, Erwin, Wibail, Alain, Barthomolé, Emmanuel, Ursell, Melanie, Sweet, Margaret Elizabeth, Howse, David, Jichici, Draga, Shawush, Melad, Namaka, Mike, Traboulsee, Anthony, Hashimoto, Stan, Lo, Raymond, Marchetti, Paul, Lapierre, Yves, Jacques, Francois, MacLean, Gregg, Bhan, Virender, Duquette, Pierre, Stewart, Bradley, Paulseth, John, Kremenchutzky, Marcelo, Vorobeychik, Galina, O'Connor, Paul, Grand'Maison, François, Havrdova, Eva, Meluzinová, Eva, Valis, Martin, Talab, Radomír, Stourac, Pavel, Zapletalová, Olga, Dufek, Michal, Sládková, Vladimíra, Novotna, Alena, Vancurová, Romana, Lhotaková, Libuse, Fiedler, Jiri, Vachova, Marta, Dolezil, David, Stetkarova, Ivana, Rehankova, Adela, Psenica, Petr, Ulehlova, Veronika, Feketova, Sona, Skoda, Ondrej, Färkkilä, Markus, Taneli, Sarasoja, Koivisto, Keijo, Seppä, Juha Matti, Airas, Laura, Elovaara, Irina, Hartikainen, Päivi, Pirttila, Tuula, Louchart, Pierre, Ille, Olivier, Thenint, Jean philippe, Godet, Etienne, Vioud, Marcel Maillet, Colamarino, Renato, Gugenheim, Michel, Grimaud, Jerome, Kopf, Audrey, Billy, Christophe, Huttin, Bernard, Borsotti, Jean paul, Devos, Philippe, Kendjuo, Jean bertin N, Verier, Albert, Chapuis, Stephane, Daluzeau, Nathalie, Angibaud, Gilles, Uriot, Marie-Sylvie Artaud, Ziegler, François, Sellal, François, Moulignier, Antoine, Lavenu, Isabelle, Ismail, Samir, Devy, Richard, Suceveanu, Manuel, Wagner, Marc, Marcel, Sebastien, Derouiche, Faycal, Mostoufizadehghalamfarsa, Sohrab, Delalande, Sophie, Ruggieri, Irene, Van Nieuwenhuyse, Catherine Bossu, Nifle, Chantal, Ondze, Basile, Vasilescu, Carmen Gurau, Vongsouthi, Cyrille, Coustans, Marc, Anne, Olivier, Amevigbe, Josephine, Servan, Jerome, Merienne, Marc, Eck, Philippe, Berroir, Stephane, Busson, Philippe, Barroso, Bruno, Larrieu, Jean-Marc, Giendaj, Catherine Louvet, Malkoun, Imad, Hautecoeur, Patrick, Kwiatkowski, Arnaud, Pouliquen, Andre, Garrigues, Guillaume, Delerue, Olivier, Giraud, Pierric, Gere, Julien, Vaunaize, Jean, Dereeper, Olivier, Seiller, Nicolas, Alsassa, Roger, Vlaicu, Mihaela, Neuville, Veronique, Faucheux, Jean Marc, Bernady, Patricia, Fanjaud, Guy, Viallet, François, Schroeter, Michael, Schlemilch-Paschen, Sylke, Lange, Thomas, Bohr, Kin-Arno, Jendroska, Klaus, Rehkopf, Elisabeth, Bergmann, Arnfin, Kleinschnitz, Christoph, Postert, Thomas, Scholz, Peter, Mauz, Uwe, Stratmann, Hubert, Siefjediers, Veneta, Prantl, Martin, Gehring, Klaus, Zellner, Ruth, Junge, Kathrin, Zellner, Anton, Bacay, Valerina, Schlegel, Eugen, Polzer, Udo, Strauss, Erik, Link, Andreas, Stenzel, Christoph, Freidel, Matthias, Drews, Joachim, Neudert, Christian, Schmitz, Frank, Jaeger, Joachim, Masri, Said, Heuberger, Wolfgang, Trausch, Beate, Ruhnke, Oliver, Scarel, Serena, Bach, Kathlen, Ernst, Michael, Landefeld, Harald, Richter, Nils, Schmidt, Stephan, Krause, Michaela, Dressel, Alezander, Ruth, Roland, Anvari, Kerstin, Gossling, Jens, Schenk, Christoph, Tiedge, Oliver, Bode, Lutz, Eder, Hans-Thomas, Pfeffer, Oliver, Krug, Reinhard, Lassek, Christoph, Fleischer, Eberhard, Meuth, Sven, Klotz, Luisa Hildegard, Peglau, Ines, Kukowski, Borries, Herting, Birgit, Guthke, Kersten, Schierenbeck, Jurgen, Brockmeier, Bernd, Albrecht, Holger, Wuttke, Matthias, Augspach-Hofmann, Regine, Gunther, Stefan, Redbrake, Martin, Franke, Christian, Buchner, Klaus, Gratz, Thomas, Horn, Rolf, Doemges, Frank, Schreiber, Martin, Brosch, Thomas, Horn, Markus, Kittlitz, Matthias, Vulturius, Gabriele, Hinse, Paul, Malessa, Rolf, Wiehler, Stephan, Katsarava, Zaza, Kastrup, Oliver, Kausch, Ulrich, Gullekes, Martin, Fickinger, Markus, Wenzel, Wilhelm, Botefur, Ingolf C., Reifschneider, Gerd, Rauer, Sebastian, Lang, Michael, Harms, Lutz, Eckhardt, Ulrich, Cursiefen, Simone, Linker, Ralf, Angstwurm, Klemens, Haas, Judith, Schuetze, Ivo, Rohm, Eva, Stienker-Fisse, H., Sailer, Michael, Bohringer, Johannes, Maurer, Mathias, Bause, Eberhard, Wersching, Ronald, Dachsel, Reinhardt, Domke, Sylke, Hoffman, Frank, Tackenberg, Bjorn, Roch, Kerstin, Ziebold, Uwe, Kallmann, Boris, Buehler, Bernhard, Faiss, Judith, Faiss, Juergen, Schimrigk, Sebastian, Menges, Christian, Knop, Karl Christian, Koehler, Wolfgang, Siever, Arno, Bufler, Johannes, Gramsl, Georg, Kuhnler, Benedicta, Maschke, Matthias, Stogbauer, Florian, Staude, Lisa, Bethke, Florian, Bitsch, Andreas, Harmjanz, Arndt D., Windsheimer, Jorg, Kieseier, Bernd C., Berkenfeld, Ralf, Tumani, Hayrettin, Kirsch, Michael, Wildemann, Brigitte, Daniels, Regina, Gottwald, Klaus, Elias, Wolfgang-Gerhard, Hoffmann, Olaf, Schwab, Matthias, Pilz, Christopher, Klostermann, Fabian, Hellwig, Kerstin, Berthele, Achim, Bayas, Antonios, Molitor, Daniel, Grothe, Christoph, Wagner, Bert, Karageorgiou, Klimentini, Mitsikostas, Dimosthenis, Kodounis, Antonios, Plaitakis, Andreas, Papadimitriou, Alexandros, Grigoriadis, Nikolaos, Vlaikidis, Nikolaos, Koutlas, Evaggelos, Kyritsis, Athanassios, Papathanassopoulos, Panagiotis, Makris, Nikolaos, Tavernarakis, Antonios, Scarpini, Elio, Montanari, Enrico, Marrosu, Maria Giovanna, Trojano, Maria, Amato, Maria Pia, Rottoli, Mariarosa, Lugaresi, Alessandra, Florio, Ciro, Gasperini, Claudio, Grimaldi, Luigi, Millefiorini, Enrico, Koudriavtseva, Tatiana, Perla, Franco, Mantegazza, Renato, Bertolotto, Antonio, Ghezzi, Angelo, Aguilar, Sandra Quinones, Eisenberg, Eli Skromne, Lopez, Leondardo Llamas, Estudillo, Rocio Marquez, Schrijver, H.M., Wittebol, M.C., Baart, J.C., van Golde, A.E.L., Hengstman, G.J.D., Pop, P.H.M., Bos (Geldrop), M., Medaer, R., Schyns-Soeterboek, Angelique, van der Zwart, A., van Diepen, A.J.H., Verheul, G.A.M., Verhagen, W.I.M., Bos (Helmond), M., Witjes, R.J.G.M., Sinnige, L.G.F., van Munster, E.Th.L., Sanders, E.A.C.M., van Dijl, Ron, Hupperts, R.M.M., Frequin, S.T.F.M., Visser, L.H., Henselmans, J.M.L., Moll, J.W.B., Midgard, Rune, Myhr, Kjell Morten, Edland, Astrid, Telstad, Wenche, Hognestad, Tone, Lund, Christian, Hovdal, Harald, Kamaljit, Kaur, Schepel, Jan, Hogenesch, Roelfien Ida, Schüler, Stephan, Odeh, Francis, Alstadhaug, Karl B., Korsgaard, Olav, Farbu, Elisabeth, Ingvaldsen, Teis Barclay, Soares (SCO), Diana, Rente, José, Guerra, José Manuel Costa, Morganho, Armando, Leitão, António, de Sá, João, Sá, Maria José, Marques, Pinto, Veloso, Mário, Baptista, Miguel Viana, Szilasiová, Jarmila, Copikova-Cudrakova, Daniela, Prochazkova, Lubica, Klimová, Eleonóra, Donath, Vladimir, Brozman, Miroslav, Ramo, Cristina, Ruiz, Domingo Pérez, Hernández, Carmen Calles, Sola, María Eugenia Marzo, Moro, Roberto Suarez, Vidal, Jose Antonio, Rodríguez, Ana Belén Caminero, Ozaeta, Gisela Martin, Nadal, Jordi Batlle, Esquide, Amaya Alvarez de Arcaya, Urtaza, Javier Olascoaga, Martínez-Yélamos, Sergio, Arbizu, Txomin, Torrenta, Lluis Ramio i, Boggild, Mike, Wilson, Martin, Al-Araji, Adnan, Nicholas, Richard, Harrower, Timothy, Redmond, Ian, Wolf, Tilo, Osei-Bonsu, Michael, Mazibrada, Gordon, Rog, David, Cottrell, David, Constantinescu, Cris, Gray, Orla, Belhag, Mohamed, Shehu, Abdullah, Rashid, Waqar, Duddy, Martin, Kappos, Ludwig, Wiendl, Heinz, Spelman, Tim, Pellegrini, Fabio, Chen, Yi, Dong, Qunming, and Koendgen, Harold

Published
2018
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22. Effect of natalizumab on disease progression in secondary progressive multiple sclerosis (ASCEND): a phase 3, randomised, double-blind, placebo-controlled trial with an open-label extension

Author

Bartholomé, Emmanuel, D'Hooghe, Marie, Pandolfo, Massimo, Van Wijmeersch, Bart, Bhan, Virender, Blevins, Gregg, Brunet, Donald, Devonshire, Virginia, Duquette, Pierre, Freedman, Mark, Grand'Maison, François, Jacques, François, Lapierre, Yves, Lee, Liesly, Morrow, Sarah, Yeung, Michael, Dufek, Michal, Havrdová, Eva Kubala, Kanovsky, Petr, Stetkarova, Ivana, Talabova, Marika, Frederiksen, Jette, Kant, Matthias, Petersen, Thor, Ravnborg, Mads, Sellebjerg, Finn, Airas, Laura, Elovaara, Irina, Eralinna, Juha-Pekka, Sarasoja, Taneli, Al Khedr, Abdullatif, Brassat, David, Brochet, Bruno, Camu, William, Debouverie, Marc, Laplaud, David, Lebrun Frenay, Christine, Pelletier, Jean, Vermersch, Patrick, Vukusi, Sandra, Baum, Karl, Berthele, Achim, Faiss, Juergen, Flachenecker, Peter, Hohlfeld, Reinhard, Krumbholz, Markus, Lassek, Christoph, Maeurer, Mathias, Meuth, Sven, Ziemssen, Tjalf, Hardiman, Orla, McGuigan, Christopher, Achiron, Anat, Karussis, Dimitrios, Bergamaschi, Roberto, Morra, Vincenzo Brescia, Comi, Giancarlo, Cottone, Salvatore, Grimaldi, Luigi, Mancardi, Giovanni Luigi, Massacesi, Luca, Nocentini, Ugo, Salvetti, Marco, Scarpini, Elio, Sola, Patrizia, Tedeschi, Gioacchino, Trojano, Maria, Zaffaroni, Mauro, Frequin, Stephan, Hupperts, Raymond, Killestein, Joep, Schrijver, Hans, Van Dijl, Ronald, van Munster, Erik, Czarnecki, Maciej, Drozdowski, Wieslaw, Fryze, Waldemar, Hertmanowska, Hanka, Ilkowski, Jan, Kaminska, Anna, Klodowska-Duda, Gabriela, Maciejowski, Maciej, Motta, Ewa, Podemski, Ryszard, Potemkowski, Andrzej, Rog, Teresa, Selmaj, Krzysztof, Stelmasiak, Zbigniew, Stepien, Adam, Tutaj, Andrzej, Zaborski, Jacek, Boyko, Alexey, Chefranova, Zanna, Evdoshenko, Evgeny, Khabirov, Farit, Sivertseva, Stella, Yakupov, Eduard, Alvarez Cermeño, Jose Carlos, Escartin, Antonio, Fernandez, Oscar Fernandez, Garcia-Merino, Antonio, Hernandez Perez, Miguel Angel, Ayuso, Guillermo Izquierdo, Lallana, José Meca, Gairin, Xavier Montalban, Oreja-Guevara, Celia, Saiz Hinarejos, Albert, Gunnarsson, Martin, Lycke, Jan, Martin, Claes, Piehl, Fredrik, Roshanisefat, Homayoun, Sundstrom, Peter, Duddy, Martin, Gran, Bruno, Harrower, Timothy, Hobart, Jeremy, Kapoor, Raju, Lee, Martin, Mattison, Paul, Nicholas, Richard, Pearson, Owen, Rashid, Waqar, Rog, David, Sharrack, Basil, Silber, Eli, Turner, Ben, Williams, Anna, Woolmore, John, Young, Carolyn, Bandari, Daniel, Berger, Joseph, Camac, Ann, Cohan, Stanley, Conway, Jill, Edwards, Keith, Fabian, Michelle, Florin, Jack, Freedman, Steven, Garwacki, Dennis, Goldman, Myla, Harrison, Daniel, Herrman, Craig, Huang, Deren, Javed, Adil, Jeffery, Douglas, Kamin, Stephen, Katsamakis, George, Khatri, Bhupendra, Langer-Gould, Annette, Lynch, Sharon, Mattson, David, Miller, Tamara, Miravalle, Augusto, Moses, Harold, Muley, Suraj, Napier, James, Nielsen, Allen, Pachner, Andrew, Pardo, Gabriel, Picone, MaryAnn, Robertson, Derrick, Royal, Walter, Sheppard, Christopher, Thrower, Ben, Twyman, Cary, Waubant, Emmanuelle, Wendt, Jeanette, Yadav, Vijayshree, Zabad, Rana, Zarelli, Greg, Ho, Pei-Ran, Campbell, Nolan, Chang, Ih, Deykin, Aaron, Forrestal, Fiona, Lucas, Nisha, Yu, Bei, Arnold, Douglas L, Freedman, Mark S, Goldman, Myla D, Hartung, Hans-Peter, Miller, Aaron, Cadavid, Diego, Mikol, Dan, and Steiner, Deborah

Published
2018
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23. Delays in Multiple Sclerosis diagnosis (DIMES): protocol for a multicentre, observational study of multiple sclerosis diagnostic pathways in the United Kingdom and Republic of Ireland.

Author

Kuri, Ashvin, primary, Henshall, David, additional, Chaudhry, Daoud, additional, Ooi, Setthasorn Zhi Yang, additional, Zhang, Qiqi, additional, Mathews, Joela, additional, Thomson, Alison, additional, Rog, David, additional, Hobart, Jeremy, additional, Dobson, Ruth, additional, and (NANSIG), Neurology and Neurosurgery Interest Group, additional

Published
2023
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24. Can Autonomous Sensor Systems Improve the Well-being of People Living at Home with Neurodegenerative Disorders?

Author

Gulrez, Tauseef, Meziani, Samia-Nefti, Rog, David, Jones, Matthew, Hodgson, Anthony, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, and Rau, Pei-Luen Patrick, editor

Published
2016
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25. ADAMS project: a genetic Association study in individuals from Diverse Ancestral backgrounds with Multiple Sclerosis based in the UK

Author

Jacobs, Benjamin M, primary, Schalk, Luisa, additional, Dunne, Angie, additional, Scalfari, Antonio, additional, Nandoskar, Ashwini, additional, Gran, Bruno, additional, Mein, Charles A, additional, Sellers, Charlotte, additional, Spilker, Cord, additional, Rog, David, additional, Visentin, Elisa, additional, Bezzina, Elizabeth Lindsey, additional, Uzochukwu, Emeka, additional, Tallantyre, Emma, additional, Wozniak, Eva, additional, Sacre, Eve, additional, Hassan-Smith, Ghaniah, additional, Ford, Helen L, additional, Harris, Jade, additional, Bradley, Joan, additional, Breedon, Joshua, additional, Brooke, Judith, additional, Kreft, Karim L, additional, Tuite Dalton, Katherine, additional, George, Katila, additional, Papachatzaki, Maria, additional, O'Malley, Martin, additional, Peter, Michelle, additional, Mattoscio, Miriam, additional, Rhule, Neisha, additional, Evangelou, Nikos, additional, Vinod, Nimisha, additional, Quinn, Outi, additional, Shamji, Ramya, additional, Kaimal, Rashmi, additional, Boulton, Rebecca, additional, Tanveer, Riffat, additional, Middleton, Rod, additional, Murray, Roxanne, additional, Bellfield, Ruth, additional, Hoque, Sadid, additional, Patel, Shakeelah, additional, Raj, Sonia, additional, Gumus, Stephanie, additional, Mitchell, Stephanie, additional, Sawcer, Stephen, additional, Arun, Tarunya, additional, Pogreban, Tatiana, additional, Brown, Terri-Louise, additional, Begum, Thamanna, additional, Antoine, Veronica, additional, Rashid, Waqar, additional, Noyce, Alastair J, additional, Silber, Eli, additional, Morris, Huw, additional, Giovannoni, Gavin, additional, and Dobson, Ruth, additional

Published
2023
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27. Outpatient neurology diagnostic coding:a proposed scheme for standardised implementation

Author

Biggin, Fran, Knight, Jo, Dayanandan, Rejith, Marson, Anthony, Wilson, Martin, Nitkunan, Arani, Rog, David, Kipps, Christopher, Mummery, Catherine, Williams, Adrian, Emsley, Hedley C A, Biggin, Fran, Knight, Jo, Dayanandan, Rejith, Marson, Anthony, Wilson, Martin, Nitkunan, Arani, Rog, David, Kipps, Christopher, Mummery, Catherine, Williams, Adrian, and Emsley, Hedley C A

Abstract

Clinical coding uses a classification system to assign standard codes to clinical terms and so facilitates good clinical practice through audit, service design and research. However, despite clinical coding being mandatory for inpatient activity, this is often not so for outpatient services, where most neurological care is delivered. Recent reports by the UK National Neurosciences Advisory Group and NHS England's 'Getting It Right First Time' initiative recommend implementing outpatient coding. The UK currently has no standardised system for outpatient neurology diagnostic coding. However, most new attendances at general neurology clinics appear to be classifiable with a limited number of diagnostic terms. We present the rationale for diagnostic coding and its benefits, and the need for clinical engagement to develop a system that is pragmatic, quick and easy to use. We outline a scheme developed in the UK that could be used elsewhere.

Published
2023

29. Developing evidence-based guidelines for the safety of symptomatic drugs in multiple sclerosis during pregnancy and breastfeeding: A systematic review and Delphi consensus

Author

Iyer, Priyanka, primary, Wiles, Kate, additional, Ismail, Azza, additional, Nanda, Surabhi, additional, Murray, Katy, additional, Hughes, Stella, additional, Ford, Helen L, additional, Pearson, Owen R, additional, White, Sarah, additional, Bonham, Nicola, additional, Hoyle, Natasha, additional, Witts, James, additional, Middleton, Rod, additional, Brex, Peter A, additional, Rog, David, additional, and Dobson, Ruth, additional

Published
2023
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30. sj-docx-3-msj-10.1177_13524585221148094 – Supplemental material for Developing evidence-based guidelines for the safety of symptomatic drugs in multiple sclerosis during pregnancy and breastfeeding: A systematic review and Delphi consensus

Author

Iyer, Priyanka, Wiles, Kate, Ismail, Azza, Nanda, Surabhi, Murray, Katy, Hughes, Stella, Ford, Helen L, Pearson, Owen R, White, Sarah, Bonham, Nicola, Hoyle, Natasha, Witts, James, Middleton, Rod, Brex, Peter A, Rog, David, and Dobson, Ruth

Subjects
FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-3-msj-10.1177_13524585221148094 for Developing evidence-based guidelines for the safety of symptomatic drugs in multiple sclerosis during pregnancy and breastfeeding: A systematic review and Delphi consensus by Priyanka Iyer, Kate Wiles, Azza Ismail, Surabhi Nanda, Katy Murray, Stella Hughes, Helen L Ford, Owen R Pearson, Sarah White, Nicola Bonham, Natasha Hoyle, James Witts, Rod Middleton, Peter A Brex, David Rog and Ruth Dobson in Multiple Sclerosis Journal

Published
2023
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31. sj-docx-1-msj-10.1177_13524585221148094 – Supplemental material for Developing evidence-based guidelines for the safety of symptomatic drugs in multiple sclerosis during pregnancy and breastfeeding: A systematic review and Delphi consensus

Author

Iyer, Priyanka, Wiles, Kate, Ismail, Azza, Nanda, Surabhi, Murray, Katy, Hughes, Stella, Ford, Helen L, Pearson, Owen R, White, Sarah, Bonham, Nicola, Hoyle, Natasha, Witts, James, Middleton, Rod, Brex, Peter A, Rog, David, and Dobson, Ruth

Subjects
FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-1-msj-10.1177_13524585221148094 for Developing evidence-based guidelines for the safety of symptomatic drugs in multiple sclerosis during pregnancy and breastfeeding: A systematic review and Delphi consensus by Priyanka Iyer, Kate Wiles, Azza Ismail, Surabhi Nanda, Katy Murray, Stella Hughes, Helen L Ford, Owen R Pearson, Sarah White, Nicola Bonham, Natasha Hoyle, James Witts, Rod Middleton, Peter A Brex, David Rog and Ruth Dobson in Multiple Sclerosis Journal

Published
2023
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32. sj-docx-2-msj-10.1177_13524585221148094 – Supplemental material for Developing evidence-based guidelines for the safety of symptomatic drugs in multiple sclerosis during pregnancy and breastfeeding: A systematic review and Delphi consensus

Author

Iyer, Priyanka, Wiles, Kate, Ismail, Azza, Nanda, Surabhi, Murray, Katy, Hughes, Stella, Ford, Helen L, Pearson, Owen R, White, Sarah, Bonham, Nicola, Hoyle, Natasha, Witts, James, Middleton, Rod, Brex, Peter A, Rog, David, and Dobson, Ruth

Subjects
FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-2-msj-10.1177_13524585221148094 for Developing evidence-based guidelines for the safety of symptomatic drugs in multiple sclerosis during pregnancy and breastfeeding: A systematic review and Delphi consensus by Priyanka Iyer, Kate Wiles, Azza Ismail, Surabhi Nanda, Katy Murray, Stella Hughes, Helen L Ford, Owen R Pearson, Sarah White, Nicola Bonham, Natasha Hoyle, James Witts, Rod Middleton, Peter A Brex, David Rog and Ruth Dobson in Multiple Sclerosis Journal

Published
2023
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33. sj-docx-4-msj-10.1177_13524585221148094 – Supplemental material for Developing evidence-based guidelines for the safety of symptomatic drugs in multiple sclerosis during pregnancy and breastfeeding: A systematic review and Delphi consensus

Author

Iyer, Priyanka, Wiles, Kate, Ismail, Azza, Nanda, Surabhi, Murray, Katy, Hughes, Stella, Ford, Helen L, Pearson, Owen R, White, Sarah, Bonham, Nicola, Hoyle, Natasha, Witts, James, Middleton, Rod, Brex, Peter A, Rog, David, and Dobson, Ruth

Subjects
FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-4-msj-10.1177_13524585221148094 for Developing evidence-based guidelines for the safety of symptomatic drugs in multiple sclerosis during pregnancy and breastfeeding: A systematic review and Delphi consensus by Priyanka Iyer, Kate Wiles, Azza Ismail, Surabhi Nanda, Katy Murray, Stella Hughes, Helen L Ford, Owen R Pearson, Sarah White, Nicola Bonham, Natasha Hoyle, James Witts, Rod Middleton, Peter A Brex, David Rog and Ruth Dobson in Multiple Sclerosis Journal

Published
2023
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36. Measuring coping in multiple sclerosis: The Coping Index-MS

Author

Young, Carolyn A, primary, Mills, Roger J, additional, Langdon, Dawn, additional, Rog, David J, additional, Sharrack, Basil, additional, Kalra, Seema, additional, Majeed, Tahir, additional, Footit, David, additional, Harrower, Tim, additional, Nicholas, Richard S, additional, Ford, Helen L, additional, Woolmore, John, additional, Johnstone, Clare, additional, Thorpe, John, additional, Paling, David, additional, Ellis, Cathy, additional, Hanneman, C Oliver, additional, and Tennant, Alan, additional

Published
2022
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42. Comparison of switching to 6-week dosing of natalizumab versus continuing with 4-week dosing in patients with relapsing-remitting multiple sclerosis (NOVA): a randomised, controlled, open-label, phase 3b trial

Author

Foley, John F, primary, Defer, Gilles, additional, Ryerson, Lana Zhovtis, additional, Cohen, Jeffrey A, additional, Arnold, Douglas L, additional, Butzkueven, Helmut, additional, Cutter, Gary, additional, Giovannoni, Gavin, additional, Killestein, Joep, additional, Wiendl, Heinz, additional, Smirnakis, Karen, additional, Xiao, Shan, additional, Kong, George, additional, Kuhelj, Robert, additional, Campbell, Nolan, additional, van der Walt, Anneke, additional, Dwyer, Christopher, additional, Buzzard, Katherine, additional, Spies, Judith, additional, Parratt, John, additional, van Pesch, Vincent, additional, Willekens, Barbara, additional, Perrotta, Gaetano, additional, Bartholomé, Emmanuel, additional, Grand'Maison, Francois, additional, Jacques, Francois, additional, Giacomini, Paul, additional, Vosoughi, Reza, additional, Girard, Jean-Marc, additional, de Seze, Jerome, additional, Lebrun Frenay, Christine, additional, Ruet, Aurelie, additional, Laplaud, David-Axel, additional, Reifschneider, Gerd, additional, Wagner, Bert, additional, Rauer, Sebastian, additional, Pul, Refik, additional, Seipelt, Maria, additional, Berthele, Achim, additional, Klotz, Luisa, additional, Kallmann, Boris-Alexander, additional, Paul, Friedemann, additional, Achiron, Anat, additional, Lus, Giacomo, additional, Centonze, Diego, additional, Patti, Francesco, additional, Grimaldi, Luigi, additional, Hupperts, Raymond, additional, Frequin, Stephan, additional, Fermont, Jiske, additional, Madueno, Sara Eichau, additional, Alonso Torres, Ana Maria, additional, Costa-Frossard França, Lucienne, additional, Meca-Lallana, Jose Eustasio, additional, Ruiz, Luis Brieva, additional, Pearson, Owen, additional, Rog, David, additional, Evangelou, Nikolaos, additional, Ismail, Azza, additional, Lathi, Ellen, additional, Fox, Edward, additional, Leist, Thomas, additional, Sloane, Jacob, additional, Wu, Gregory, additional, Khatri, Bhupendra, additional, Steingo, Brian, additional, Thrower, Ben, additional, Gudesblatt, Mark, additional, Calkwood, Jonathan, additional, Bandari, Daniel, additional, Scagnelli, John, additional, Laganke, Christopher, additional, Robertson, Derrick, additional, Kipp, Lucas, additional, Belkin, Martin, additional, Cohan, Stanley, additional, Goldstick, Lawrence, additional, Courtney, Ardith, additional, Vargas, Wendy, additional, Sylvester, Andrew, additional, Srinivasan, Jayshri, additional, Kannan, Meena, additional, Picone, Maryann, additional, English, Jeffrey, additional, Napoli, Salvatore, additional, Balabanov, Roumen, additional, Zaydan, Islam, additional, Nicholas, Jacqueline, additional, Kaplan, Jeffrey, additional, Lublin, Fred, additional, Riser, Emily, additional, Miller, Tamara, additional, Alvarez, Enrique, additional, Wray, Sibyl, additional, Gross, Jeffrey, additional, Pawate, Siddharama, additional, Hersh, Carrie, additional, McCarthy, Lucas, additional, Crayton, Heidi, additional, and Graves, Jennifer, additional

Published
2022
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43. Evaluating the feasibility of a real world pharmacovigilance study (OPTIMISE:MS)

Author

Dobson, Ruth, primary, Craner, Matthew, additional, Waddingham, Ed, additional, Miller, Aleisha, additional, Pindoria, Jayant, additional, Cavey, Ana, additional, Blain, Camilla, additional, De Luca, Gabriele, additional, Evangelou, Nikos, additional, Ford, Helen, additional, Gallagher, Paul, additional, George, Katila, additional, Geraldes Ramos Dias, Ruth, additional, Harman, Paula, additional, Hobart, Jeremy, additional, King, Tanya, additional, Linighan, Ruth, additional, MacDougall, Niall, additional, Marta, Monica, additional, Mitchell, Stephanie, additional, Nicholas, Richard, additional, Rog, David, additional, Scalfari, Antonio, additional, Scolding, Neil, additional, Webb, Stewart, additional, White, Sarah, additional, Wilton, Judith, additional, Young, Carolyn, additional, and Matthews, Paul M, additional

Published
2022
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44. “I'm walking into the unknown': Qualitative insights into how emotions and lived experience related to multiple sclerosis diagnosis impact on decisions to pursue disease modifying treatment

Author

Carey, Gina, Wilson, Neil, Janssen, Jessie, Chohan, Ambreen, Rog, David, Roddam, Hazel, Carey, Gina, Wilson, Neil, Janssen, Jessie, Chohan, Ambreen, Rog, David, and Roddam, Hazel

Abstract

Introduction : People with Relapsing Remitting Multiple Sclerosis (RRMS) are increasingly included as active participants in shared decision making around their treatment options. Choosing a first disease modifying treatment (DMT) is a complex process that often takes place soon after a diagnosis has been given. Patients therefore are often required to make difficult decisions at a time when they are still coming to terms with their illness. This study investigated the views and experiences of recently diagnosed patients with RRMS when they were making their initial DMT choice. Method : This was a qualitative study involving in-depth semi-structured interviews with patients with RRMS in a National Health Service (NHS) setting in the United Kingdom. Data were collected from 6 patients and analysis was guided by an Interpretive Phenomenological Analysis (IPA) approach. Results : Initial reactions to diagnosis were characterized by strong emotions and a feeling of despair and hopelessness. Subsequently the DMT decision was shaped by multiple considerations around maintaining normality, and restoring hope and control over one's life whilst reconciling uncertainty around efficacy. Considering the future with a DMT elicited reflections around employment and family planning. Conclusion : Emotions and lived experience related to recent MS diagnosis can impact on the initial DMT decision in number of ways. Health care professionals need to understand the lived experience of patients making DMT decisions soon after diagnosis when engaging in shared decision making.

Published
2022

45. The impact of smoking cessation on multiple sclerosis disease progression

Author

Rodgers, Jeff, Friede, Tim, Vonberg, Frederick W, Constantinescu, Cris S, Coles, Alasdair, Chataway, Jeremy, Duddy, Martin, Emsley, Hedley, Ford, Helen, Fisniku, Leonora, Galea, Ian, Harrower, Timothy, Hobart, Jeremy, Huseyin, Huseyin, Kipps, Christopher M, Marta, Monica, McDonnell, Gavin V, McLean, Brendan, Pearson, Owen R, Rog, David, Schmierer, Klaus, Sharrack, Basil, Straukiene, Agne, Wilson, Heather C, Ford, David V, Middleton, Rod M, Nicholas, Richard, Rodgers, Jeff, Friede, Tim, Vonberg, Frederick W, Constantinescu, Cris S, Coles, Alasdair, Chataway, Jeremy, Duddy, Martin, Emsley, Hedley, Ford, Helen, Fisniku, Leonora, Galea, Ian, Harrower, Timothy, Hobart, Jeremy, Huseyin, Huseyin, Kipps, Christopher M, Marta, Monica, McDonnell, Gavin V, McLean, Brendan, Pearson, Owen R, Rog, David, Schmierer, Klaus, Sharrack, Basil, Straukiene, Agne, Wilson, Heather C, Ford, David V, Middleton, Rod M, and Nicholas, Richard

Abstract

The negative impact of smoking in multiple sclerosis is well established; however, there is much less evidence as to whether smoking cessation is beneficial to progression in multiple sclerosis. Adults with multiple sclerosis registered on the United Kingdom Multiple Sclerosis Register (2011–20) formed this retrospective and prospective cohort study. Primary outcomes were changes in three patient-reported outcomes: normalized Multiple Sclerosis Physical Impact Scale (MSIS-29-Phys), normalized Multiple Sclerosis Walking Scale (MSWS-12) and the Hospital Anxiety and Depression Scale (HADS). Time to event outcomes were clinically significant increases in the patient-reported outcomes. The study included 7983 participants; 4130 (51.7%) of these had ever smoked, of whom 1315 (16.5%) were current smokers and 2815/4130 (68.2%) were former smokers. For all patient-reported outcomes, current smokers at the time of completing their first questionnaire had higher patient-reported outcomes scores indicating higher disability compared to those who had never smoked (∼10 points difference in MSIS-29-Phys and MSWS-12; 1.5–1.8 points for HADS-Anxiety and HADS-Depression). There was no improvement in patient-reported outcomes scores with increasing time since quitting in former smokers. Nine hundred and twenty-three participants formed the prospective parallel group, which demonstrated that MSIS-29-Phys [median (IQR) 5.03 (3.71, 6.34)], MSWS-12 [median (IQR) 5.28 (3.62, 6.94)] and HADS-Depression [median (IQR) 0.71 (0.47, 0.96)] scores worsened over a period of 4 years, whereas HADS-Anxiety remained stable. Smoking status was significant at Year 4; current smokers had higher MSIS-29-Phys and HADS-Anxiety scores [median (IQR) 3.05 (0.22, 5.88) and 1.14 (0.52, 1.76), respectively] while former smokers had a lower MSIS-29-Phys score of −2.91 (−5.03, −0.79). A total of 4642 participants comprised the time to event analysis. Still smoking was associated with a shorter time to worsening eve

Published
2022

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