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1. External validation of the myocardial-ischaemic-injury-index machine learning algorithm for the early diagnosis of myocardial infarction: a multicentre cohort study

Author

Reichlin, Tobias, Kaeslin, Marina, Potlukova, Eliska, Kawecki, Damian, Geigy, Nicolas, Rentsch, Katharina, Shrestha, Samyut, Guzman-Tacla, Caroline A., Herraiz-Recuenco, Lourdes, Morawiec, Beata, Munzk, Piotr, Freese, Michael, Martinez-Nadal, Gemma, Fuenzalida, Carolina, Calderon, Sofia, Rodriguez Adrada, Esther, Ganovská, Eva, Parenica, Jiri, von Eckardstein, Arnold, Campodarve, Isabel, Gea, Joachim, Lopez-Ayala, Pedro, Boeddinghaus, Jasper, Nestelberger, Thomas, Koechlin, Luca, Zimmermann, Tobias, Bima, Paolo, Glaeser, Jonas, Spagnuolo, Carlos C, Champetier, Arnaud, Miro, Oscar, Martin-Sanchez, Francisco Javier, Keller, Dagmar I, Christ, Michael, Wildi, Karin, Breidthardt, Tobias, Strebel, Ivo, and Mueller, Christian

Published
2024
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2. Effect of Flu Vaccination on Severity and Outcome of Heart Failure Decompensations

Author

Miró, ÒSCAR, IVARS, NICOLE, LOPEZ-AYALA, PEDRO, GIL, VÍCTOR, LLAUGER, LLUÍS, ALQUÉZAR-ARBÉ, AITOR, JACOB, JAVIER, RODRÍGUEZ-ADRADA, ESTHER, TOST, JOSEP, MIR, MARÍA, GIL, CRISTINA, SÁNCHEZ, SUSANA, AGUIRRE, ALFONS, MARTÍN, ENRIQUE, ALONSO, M. ISABEL, GARRIDO, JOSÉ MANUEL, LÓPEZ-GRIMA, M. LUISA, LUCAS-IMBERNON, FRANCISCO JAVIER, SÁNCHEZ, CAROLINA, ESCODA, ROSA, GIL, ADRIANA, ESPINOSA, BEGOÑA, WUSSLER, DESIREE, PEACOCK, W. FRANK, MUELLER, CHRISTIAN, and LLORENS, PERE

Published
2023
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3. Analysis of standards of quality for outcomes in acute heart failure patients directly discharged home from emergency departments and their relationship with the emergency department direct discharge rate

Author

Fuentes, Marta, Gil, Cristina, Alonso, Héctor, Pérez-Llantada, Enrique, Martín-Sánchez, Francisco Javier, García, Guillermo Llopis, Cadenas, Mar Suárez, Miró, Òscar, Gil, Víctor, Escoda, Rosa, Aguiló, Sira, Sánchez, Carolina, Pérez-Durá, María José, Salvo, Eva, Pavón, José, Noval, Antonio, Manuel Torres, José, López-Grima, María Luisa, Valero, Amparo, Juan, María Ángeles, Aguirre, Alfons, Pedragosa, Maria Angels, Masó, Silvia Mínguez, Alonso, María Isabel, Ruiz, Francisco, Miguel Franco, José, Mecina, Ana Belén, Tost, Josep, Berenguer, Marta, Donea, Ruxandra, Ramón, Susana Sánchez, Rodríguez, Virginia Carbajosa, Piñera, Pascual, Andrés Sánchez Nicolás, José, Garate, Raquel Torres, Alquézar-Arbé, Aitor, Rizzi, Miguel Alberto, Herrera, Sergio, Jacob, Javier, Roset, Alex, Cabello, Irene, Haro, Antonio, Richard, Fernando, María Álvarez Pérez, José, Diez, María Pilar López, Puente, Pablo Herrero, Álvarez, Joaquín Vázquez, García, Belén Prieto, García, María García, González, Marta Sánchez, Llorens, Pere, Javaloyes, Patricia, Marquina, Víctor, Jiménez, Inmaculada, Hernández, Néstor, Brouzet, Benjamín, Espinosa, Begoña, Gil, Adriana, Andueza, Juan Antonio, Romero, Rodolfo, Ruíz, Martín, Calvache, Roberto, Serralta, María Teresa Lorca, Jave, Luis Ernesto Calderón, Arriaga, Beatriz Amores, Bergua, Beatriz Sierra, Mojarro, Enrique Martín, Jiménez, Brigitte Silvana Alarcón, Bécquer, Lisette Travería, Burillo, Guillermo, García, Lluís Llauger, LaSalle, Gerard Corominas, Urbano, Carmen Agüera, Soto, Ana Belén García, Padial, Elisa Delgado, Ferrer, Ester Soy, Múñoz, María Adroher, Manuel Garrido, José, Lucas-Imbernón, Francisco Javier, Gaya, Rut, Bibiano, Carlos, Mir, María, Rodríguez, Beatriz, Luis Carballo, José, Rodríguez-Adrada, Esther, Miranda, Belén Rodríguez, Martín, Monika Vicente, Casanova, Pere Coma, Alvarós, Joan Espinach, López-Díez, María Pilar, Rossello, Xavier, Herrero, Pablo, Alquézar, Aitor, Garrido, José Manuel, Lucas-Invernón, Francisco Javier, Torres-Murillo, José, Raquel-Torres-Gárate, Mecina, Ana B., Traveria, Lissette, Agüera, Carmen, Takagi, Koji, Möckel, Martin, Pang, Peter S., Collins, Sean P., and Mueller, Christian E.

Published
2021
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4. Influence of the length of hospitalisation in post-discharge outcomes in patients with acute heart failure: Results of the LOHRCA study

Author

Miró, Òscar, Padrosa, Joan, Takagi, Koji, Gayat, Étienne, Gil, Víctor, Llorens, Pere, Martín-Sánchez, Francisco Javier, Herrero-Puente, Pablo, Jacob, Javier, Montero, María Mir, Tost, Josep, Díez, María Pilar López, Traveria, Lissete, Torres-Gárate, Raquel, Alonso, María Isabel, Agüera, Carmen, Valero, Amparo, Javaloyes, Patricia, Peacock, W. Frank, Bueno, Héctor, Mebazaa, Alexandre, Fuentes, Marta, Gil, Cristina, Alonso, Héctor, Garmila, Pablo, García, Guillermo Llopis, Yáñez-Palma, María Cecilia, López, Sergio Iglesias, Escoda, Rosa, Xipell, Carolina, Sánchez, Carolina, Gaytan, Josep María, Pérez-Durá, María José, Salvo, Eva, Pavón, José, Noval, Antonio, Torres, José Manuel, López-Grima, María Luisa, Juan, Marian Ángeles, Aguirre, Alfons, Morales, Julián Errasti, Masó, Silvia Mínguez, Ruiz, Francisco, Franco, José Miguel, Mecina, Ana Belén, Sánchez, Susana, Carbajosa, Virginia, Piñera, Pascual, Nicolás, José Andrés Sánchez, Garate, Raquel Torres, Alquezar, Aitor, Rizzi, Miguel Alberto, Herrera, Sergio, Roset, Alex, Cabello, Irene, Richard, Fernando, Pérez, José María Álvarez, Diez, María Pilar López, Álvarez, Joaquín Vázquez, García, Belén Prieto, Sánchez González, María García García yMarta, Marquina, Víctor, Jiménez, Inmaculada, Hernández, Néstor, Brouzet, Benjamín, Ramos, Sergio, López, Ana, Andueza, Juan Antonio, Romero, Rodolfo, Ruíz, Martín, Calvache, Roberto, Lorca, María Teresa, Calderón, Luis, Arriaga, Beatriz Amores, Sierra, Beatriz, Mojarro, Enrique Martín, Bécquer, Lisette Travería, Burillo, Guillermo, García, Lluís Llauger, LaSalle, Gerard Corominas, Urbano, Carmen Agüera, Soto, Ana Belén García, Padial, Elisa Delgado, Ferrer, Ester Soy, Garrido, Manuel, Lucas, Francisco Javier, Gaya, Rut, Bibiano, Carlos, Mir, María, Rodríguez, Beatriz, Sánchez, Natalia, Carballo, José Luis, Rodríguez-Adrada, Esther, and Rodríguez, Belén

Published
2019
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5. Acute heart failure and adverse events associated with the presence of renal dysfunction and hyperkalaemia. EAHFE- renal dysfunction and hyperkalaemia

Author

Gil, Cristina, Alonso, Héctor, Pérez-Llantada, Enrique, Llopis-García, Guillermo, Santos-Matallana, Maria Carmen, Barrenechea-Moxó, María Luisa Docavo, Salgado-Pérez, Lucía, Escoda, Rosa, Xipell, Carolina, Sánchez, Carolina, Gaytan, Josep María, Pérez-Durá, María José, Salvo, Eva, Pavón, José, Noval, Antonio, Torres, José Manuel, López-Grima, María Luisa, Valero, Amparo, Juan, María Ángeles, Aguirre, Alfons, Pedragosa, Maria Angels, Mínguez-Masó, Silvia, Alonso, María Isabel, Ruiz, Francisco, Franco, José Miguel, Mecina, Ana Belén, Tost, Josep, Berenguer, Marta, Donea, Ruxandra, Sánchez-Ramón, Susana, Carbajosa-Rodríguez, Virginia, Piñera, Pascual, Sánchez-Nicolás, José Andrés, Garate, Raquel Torres, Alquézar-Arbé, Aitor, Rizzi, Miguel Alberto, Herrera, Sergio, Roset, Alex, Cabello, Irene, Haro, Antonio, Richard, Fernando, Álvarez-Perez, José María, López-Diez, María Pilar, Vázquez-Álvarez, Joaquín, Prieto-García, Belén, García, María García, González, Marta Sánchez, Javaloyes, Patricia, Marquina, Víctor, Jiménez, Inmaculada, Hernández, Néstor, Brouzet, Benjamín, Espinosa, Begoña, Andueza, Juan Antonio, Romero, Rodolfo, Ruíz, Martín, Calvache, Roberto, Serralta, María Teresa Lorca, Jave, Luis Ernesto Calderón, Arriaga, Beatriz Amores, Bergua, Beatriz Sierra, Mojarro, Enrique Martín, Jiménez, Brigitte Silvana Alarcón, Bécquer, Lisette Travería, Burillo, Guillermo, García, Lluís Llauger, LaSalle, Gerard Corominas, Urbano, Carmen Agüera, Soto, Ana Belén García, Padial, Elisa Delgado, Ferrer, Ester Soy, Garrido, José Manuel, Lucas-Imbernón, Francisco Javier, Gaya, Rut, Bibiano, Carlos, Mir, María, Rodríguez, Beatriz, Carballo, José Luis, Rodríguez-Adrada, Esther, Miranda, Belén Rodríguez, Jacob, Javier, Llauger, Lluis, Herrero-Puente, Pablo, Martín-Sánchez, Francisco Javier, Llorens, Pere, Gil, Victor, Fuentes, Marta, and Miró, Òscar

Published
2019
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6. Effect of risk of malnutrition on 30-day mortality among older patients with acute heart failure in Emergency Departments

Author

Martín-Sánchez, Francisco Javier, Cuesta Triana, Federico, Rossello, Xavier, Pardo García, Rebeca, Llopis García, Guillermo, Caimari, Francisca, Vidán, María Teresa, Ruiz Artacho, Pedro, González del Castillo, Juan, Llorens, Pere, Herrero, Pablo, Jacob, Javier, Gil, Víctor, Fernández Pérez, Cristina, Gil, Pedro, Bueno, Héctor, Miró, Òscar, Matía Martín, Pilar, Rodríguez Adrada, Esther, Santos, María Carmen, Salgado, Lucía, Brizzi, Berenice Nayla, Docavo, María Luisa, del Mar Suárez-Cadenas, María, Xipell, Carolina, Sánchez, Carolina, Aguiló, Sira, Gaytan, Josep María, Jerez, Alba, Pérez-Durá, María José, Berrocal Gil, Pablo, López-Grima, María Luisa, Valero, Amparo, Aguirre, Alfons, Pedragosa, Maria Àngels, Piñera, Pascual, LázaroAragues, Paula, Sánchez Nicolás, José Andrés, Rizzi, Miguel Alberto, Herrera Mateo, Sergio, Alquezar, Aitor, Roset, Alex, Ferrer, Carles, Llopis, Ferrán, Álvarez Pérez, José María, López Diez, María Pilar, Richard, Fernando, Fernández-Cañadas, José María, Carratalá, José Manuel, Javaloyes, Patricia, Andueza, Juan Antonio, Sevillano Fernández, José Antonio, Romero, Rodolfo, Merlo Loranca, Marta, Álvarez Rodríguez, Virginia, Lorca, María Teresa, Calderón, Luis, Soy Ferrer, Ester, Manuel Garrido, José, and Martín Mojarro, Enrique

Published
2019
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7. Effect of Barthel Index on the Risk of Thirty-Day Mortality in Patients With Acute Heart Failure Attending the Emergency Department: A Cohort Study of Nine Thousand Ninety-Eight Patients From the Epidemiology of Acute Heart Failure in Emergency Departments Registry

Author

Fuentes, Marta, Gil, Cristina, Alonso, Héctor, Garmila, Pablo, Rodríguez Adrada, Esther, Llopis García, Guillermo, Yáñez-Palma, M. Cecilia, López, Sergio Iglesias, Escoda, Rosa, Xipell, Carolina, Sánchez, Carolina, Gaytan, Josep M<ce:sup loc='post">a</ce:sup>, Pérez-Durá, María José, Salvo, Eva, Pavón, José, Noval, Antonio, Torres, José M., López-Grima, María Luisa, Valero, Amparo, Juan, Marian Ángeles, Aguirre, Alfons, Morales, Julián Errasti, Mínguez Masó, Silvia, Isabel Alonso, María, Ruiz, Francisco, Miguel Franco, José, Díaz, Elena, Belén Mecina, Ana, Tost, Josep, Sánchez, Susana, Carbajosa, Virginia, Piñera, Pascual, Sánchez Nicolás, José Andrés, Torres Garate, Raquel, Alquezar, Aitor, Alberto Rizzi, Miguel, Herrera, Sergio, Roset, Alex, Cabello, Irene, Richard, Fernando, Álvarez Pérez, José María, Pilar López Diez, María, Vázquez Álvarez, Joaquín, Alonso Morilla, Ana, Irimia, Andrea, Javaloyes, Patricia, Marquina, Víctor, Jiménez, Inmaculada, Hernández, Néstor, Brouzet, Benjamín, Ramos, Sergio, López, Ana, Antonio Andueza, Juan, Antonio Sevillano, José, Romero, Rodolfo, Calvache, Roberto, Lorca, María Teresa, Calderón, Luis, Amores Arriaga, Beatriz, Sierra, Beatriz, Martín Mojarro, Enrique, Travería Bécquer, Lisette, Burillo, Guillermo, Llauger García, Lluís, Corominas LaSalle, Gerard, Agüera Urbano, Carmen, Belén García, Ana, Elisa Delgado Padial, Soto, Soy Ferrer, Ester, Garrido, Manuel, Javier Lucas, Francisco, Gaya, Rut, Rossello, Xavier, Miró, Òscar, Llorens, Pere, Jacob, Javier, Herrero-Puente, Pablo, Gil, Víctor, Rizzi, Miguel A., Pérez-Durá, María J., Espiga, Fernando R., Sevillano, José A., Vidán, María T., Bueno, Héctor, Pocock, Stuart J., and Martín-Sánchez, Francisco J.

Published
2019
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8. Adherence to Mediterranean Diet and All-Cause Mortality After an Episode of Acute Heart Failure: Results of the MEDIT-AHF Study

Author

Alonso, Héctor, Fuentes, Marta, Gil, Cristina, Pérez-Durá, María José, Salvo, Eva, Escoda, Rosa, Xipell, Carolina, Sánchez, Carolina, Gaytan, Josep M., Noval, Antonio, Torres, José M., López-Grima, Maria Luisa, Juan, Maria Angeles, Valero, Amparo, Pedragosa, Maria Àngels, Alonso, Maria Isabel, Ruiz, Francisco, Romero, Rodolfo, Calvache, Roberto, Morante, Carlos, Lorca, Maria Teresa, Mecina, Ana Belen, Tost, Josep, de la Fuente Penco, Belén, López Sánchez, Antònia, Sánchez, Susana, Piñera, Pascual, Garate, Raquel Torres, Alquézar, Aitor, Rizzi, Miguel Alberto, Richard, Fernando, Álvarez Pérez, José María, López Diez, Maria Pilar, Lucas, Javier, Roset, Álex, Rodríguez-Adrada, Esther, Llopis García, Guillermo, Garrido, José Manuel, Fernández-Cañadas, José Maria, Marquina, Víctor, Jiménez, Inmaculada, Javaloyes, Patricia, Vázquez Alvarez, Joaquin, Alonso Morilla, Ana, Irimia, Andrea, Miró, Òscar, Estruch, Ramon, Martín-Sánchez, Francisco J., Gil, Víctor, Jacob, Javier, Herrero-Puente, Pablo, Herrera Mateo, Sergio, Aguirre, Alfons, Andueza, Juan A., and Llorens, Pere

Published
2018
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9. External validation of the myocardial-ischaemic-injury-index machine learning algorithm for the early diagnosis of myocardial infarction: a multicentre cohort study

Author

Lopez-Ayala, Pedro, Boeddinghaus, Jasper, Nestelberger, Thomas, Koechlin, Luca, Zimmermann, Tobias, Bima, Paolo, Glaeser, Jonas, Spagnuolo, Carlos C, Champetier, Arnaud, Miro, Oscar, Martin-Sanchez, Francisco Javier, Keller, Dagmar I, Christ, Michael, Wildi, Karin, Breidthardt, Tobias, Strebel, Ivo, Mueller, Christian, Reichlin, Tobias, Kaeslin, Marina, Potlukova, Eliska, Kawecki, Damian, Geigy, Nicolas, Rentsch, Katharina, Shrestha, Samyut, Guzman-Tacla, Caroline A., Herraiz-Recuenco, Lourdes, Morawiec, Beata, Munzk, Piotr, Freese, Michael, Martinez-Nadal, Gemma, Fuenzalida, Carolina, Calderon, Sofia, Rodriguez Adrada, Esther, Ganovská, Eva, Parenica, Jiri, von Eckardstein, Arnold, Campodarve, Isabel, and Gea, Joachim

Abstract

The myocardial-ischaemic-injury-index (MI3) is a novel machine learning algorithm for the early diagnosis of type 1 non-ST-segment elevation myocardial infarction (NSTEMI). The performance of MI3, both when using early serial blood draws (eg, at 1 h or 2 h) and in direct comparison with guideline-recommended algorithms, remains unknown. Our aim was to externally validate MI3and compare its performance with that of the European Society of Cardiology (ESC) 0/1h-algorithm.

Published
2024
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10. Morphine Use in the ED and Outcomes of Patients With Acute Heart Failure: A Propensity Score-Matching Analysis Based on the EAHFE Registry

Author

Fuentes, Marta, Gil, Cristina, Pérez-durá, María José, Salvo, Eva, Vallés, José, Escoda, Rosa, Xipell, Carolina, Sánchez, Carolina, Pavón, José, Álvarez, Ana Bella, Noval, Antonio, Torres, José M., López-Grima, Maria Luisa, Valero, Amparo, Aguirre, Alfons, Pedragosa, Maria Àngels, Alonso, Maria Isabel, Sancho, Helena, Ruiz, Paco, Giménez, Antonio, Miguel Franco, José, Pardo, Sergio, Mecina, Ana Belen, Tost, Josep, Fabregat, Jordi, Sánchez, Susana, Piñera, Pascual, Garate, Raquel Torres, Alquezar, Aitor, Rizzi, Miguel Alberto, Richard, Fernando, Lucas, Javier, Cabello, Irene, Roset, Álex, Rodríguez-Adrada, Esther, García, Guillermo Llopis, Garrido, José Manuel, Miró, Òscar, Gil, Víctor, Martín-Sánchez, Francisco J., Herrero-Puente, Pablo, Jacob, Javier, Mebazaa, Alexandre, Harjola, Veli-Pekka, Ríos, José, Hollander, Judd E., Peacock, W. Frank, and Llorens, Pere

Published
2017
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11. Impact of Frailty and Disability on 30-Day Mortality in Older Patients With Acute Heart Failure

Author

Pérez-Durá, María José, Gil, Pablo Berrocal, Miró, Óscar, Espinosa, Víctor Gil, Sánchez, Carolina, Aguiló, Sira, Vall, Maria Àngels Pedragosa, Aguirre, Alfons, Piñera, Pascual, Aragues, Paula Lázaro, Bordigoni, Miguel Alberto Rizzi, Alquezar, Aitor, Richard, Fernando, Jacob, Javier, Ferrer, Carles, Llopis, Ferrán, Sánchez, F. Javier Martín, del Castillo, Juan González, Rodríguez-Adrada, Esther, García, Guillermo Llopis, Salgado, Lucía, Mandly, Eduardo Anguita, Ortega, Julián Sanz, de los Ángeles Cuadrado Cenzual, María, de Heredia, Maria Dolores Inés Ortega, Soriano, Pere Llorens, Fernández-Cañadas, José María, Carratalá, José Manuel, Javaloyes, Patricia, Puente, Pablo Herrero, García, Iván Rancaño, Coya, María Fernández, Fernández, José Antonio Sevillano, Andueza, Juan, Pareja, Rodofo Romero, del Arco, Carmen, Martín, Alfonso, Torres, Raquel, Miranda, Belén Rodríguez, Martín, Vanesa Sendín, Guillén, Carlos Bibiano, Puig, Rodrigo Pacheco, Martín-Sánchez, Francisco Javier, Vidan, Maria Teresa, Llopis García, Guillermo, González del Castillo, Juan, Rizzi, Miguel Alberto, Lázaro Aragues, Paula, Llorens, Pere, Herrero, Pablo, Gil, Víctor, Fernández, Cristina, Bueno, Héctor, and Miró, Òscar

Published
2017
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13. Early diagnosis of acute myocardial infarction in patients with mild elevations of cardiac troponin

Author

Boeddinghaus, Jasper, Reichlin, Tobias, Nestelberger, Thomas, Twerenbold, Raphael, Meili, Yvette, Wildi, Karin, Hillinger, Petra, Giménez, Maria Rubini, Cupa, Janosch, Schumacher, Lukas, Schubera, Marie, Badertscher, Patrick, Corbière, Sydney, Grimm, Karin, Puelacher, Christian, Sabti, Zaid, Widmer, Dayana Flores, Schaerli, Nicolas, Kozhuharov, Nikola, Shrestha, Samyut, Bürge, Tobias, Mächler, Patrick, Büchi, Michael, Rentsch, Katharina, Miró, Òscar, López, Beatriz, Martin-Sanchez, F. Javier, Rodriguez-Adrada, Esther, Morawiec, Beata, Kawecki, Damian, Ganovská, Eva, Parenica, Jiri, Lohrmann, Jens, Buser, Andreas, Keller, Dagmar I., Osswald, Stefan, and Mueller, Christian

Published
2017
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14. Direct Comparison of the 0/1h and 0/3h Algorithms for Early Rule-Out of Acute Myocardial Infarction

Author

Badertscher, Patrick, Boeddinghaus, Jasper, Twerenbold, Raphael, Nestelberger, Thomas, Wildi, Karin, Wussler, Desiree, Schwarz, Jonas, Puelacher, Christian, Rubini Giménez, Maria, Kozhuharov, Nikola, du Fay de Lavallaz, Jeanne, Cerminara, Sara Elisa, Potlukova, Eliska, Rentsch, Katharina, Miró, Òscar, López, Beatriz, Martin-Sanchez, F. Javier, Morawiec, Beata, Muzyk, Piotr, Keller, Dagmar I., Reichlin, Tobias, Mueller, Christian, Sabti, Zaid, Strebel, Ivo, Shrestha, Samyut, Flores, Dayana, Freese, Michael, Stelzig, Claudia, Kulangara, Caroline, Meissner, Kathrin, Schaerli, Nicolas, Mueller, Deborah, Yufera Sanchez, Ana, Sazgary, Lorraine, Marbot, Stella, Fuenzalida, Carolina, Calderón, Sofia, Rodriguez Adrada, Esther, Kawecki, Damian, Nowalany-Kozielska, Ewa, Parenica, Jiri, Ganovská, Eva, von Eckardstein, Arnold, Lohrmann, Jens, Kloos, Wanda, Osswald, Stefan, Buser, Andreas, Bingisser, Roland, and Geigy, Nicolas

Published
2018
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15. Direct Comparison of 4 Very Early Rule-Out Strategies for Acute Myocardial Infarction Using High-Sensitivity Cardiac Troponin I

Author

Boeddinghaus, Jasper, Nestelberger, Thomas, Twerenbold, Raphael, Wildi, Karin, Badertscher, Patrick, Cupa, Janosch, Bürge, Tobias, Mächler, Patrick, Corbière, Sydney, Grimm, Karin, Giménez, Maria Rubini, Puelacher, Christian, Shrestha, Samyut, Flores Widmer, Dayana, Fuhrmann, Jakob, Hillinger, Petra, Sabti, Zaid, Honegger, Ursina, Schaerli, Nicolas, Kozhuharov, Nikola, Rentsch, Katharina, Miró, Òscar, López, Beatriz, Martin-Sanchez, F. Javier, Rodriguez-Adrada, Esther, Morawiec, Beata, Kawecki, Damian, Ganovská, Eva, Parenica, Jiri, Lohrmann, Jens, Kloos, Wanda, Buser, Andreas, Geigy, Nicolas, Keller, Dagmar I., Osswald, Stefan, Reichlin, Tobias, and Mueller, Christian

Published
2017
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17. Sensitivity of the SNNOOP10 list in the high-risk secondary headache detection

Author

García-Azorín, David, Abelaira-Freire, Jaime, González-García, Nuria, Rodriguez-Adrada, Esther, Schytz, Henrik Winther, Barloese, Mads, Guerrero, Ángel Luis, Porta-Etessam, Jesús, Martín-Sánchez, Francisco Javier, García-Azorín, David, Abelaira-Freire, Jaime, González-García, Nuria, Rodriguez-Adrada, Esther, Schytz, Henrik Winther, Barloese, Mads, Guerrero, Ángel Luis, Porta-Etessam, Jesús, and Martín-Sánchez, Francisco Javier

Abstract

Aim: To evaluate the diagnostic accuracy of the SNNOOP10 list in the detection of high-risk headaches. Methods: Patients that visited the Hospital Clínico San Carlos (Madrid) emergency department due to headache that were allocated to a Manchester Triage System level between critical and urgent were prospectively included but retrospectively analysed. A researcher blind to the patients’ diagnosis administered a standardised questionnaire and afterwards a neurologist blind to the questionnaire results diagnosed the patient according to the International Classification of Headache Disorders. The primary endpoint was to assess the sensitivity of the SNNOOP10 list in the detection of high-risk headaches. Secondary endpoints included the evaluation of the sensitivity, specificity, positive predictive value, negative predictive value and area under the curve of each SNNOOP10 item. Results: Between April 2015 and October 2021, 100 patients were included. Patients were 44 years old (inter-quartile range: 33.6–64.7) and 57% were female. We identified 37 different diagnoses. Final diagnosis was a primary headache in 33%, secondary headache in 65% and cranial neuralgia in 2%. There were 46 patients that were considered as having high-risk headache. Patients from the primary headache group were younger and more frequently female. Sensitivity of SNNOOP10 list was 100% (95% confidence interval: 90.2%–100%). The items with higher sensitivity were neurologic deficit or disfunction (75.5%), pattern change or recent onset of the headache (64.4%), onset after 50 years (64.4%). The most specific items were posttraumatic onset of headache (94.5%), neoplasm in history (89.1%) and systemic symptoms (89%). The area under the curve of the SNNOOP10 list was 0.66 (95% CI: 0.55–0.76). Conclusion: The red flags from the SNNOOP10 list showed a 100% sensitivity in the detection of high-risk headache disorders.

Published
2022

18. sj-pdf-1-cep-10.1177_03331024221120249 - Supplemental material for Sensitivity of the SNNOOP10 list in the high-risk secondary headache detection

Author

García-Azorín, David, Abelaira-Freire, Jaime, González-García, Nuria, Rodriguez-Adrada, Esther, Schytz, Henrik Winther, Barloese, Mads, Guerrero, Ángel Luis, Porta-Etessam, Jesús, and Martín-Sánchez, Francisco Javier

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy), 110306 Endocrinology, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, sj-pdf-1-cep-10.1177_03331024221120249 for Sensitivity of the SNNOOP10 list in the high-risk secondary headache detection by David García-Azorín, Jaime Abelaira-Freire, Nuria González-García, Esther Rodriguez-Adrada, Henrik Winther Schytz, Mads Barloese, Ángel Luis Guerrero, Jesús Porta-Etessam and Francisco Javier Martín-Sánchez in Cephalalgia

Published
2022
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19. Novel Criteria for the Observe-Zone of the ESC 0/1h-hs-cTnT Algorithm

Author

Lopez-Ayala, Pedro, primary, Nestelberger, Thomas, additional, Boeddinghaus, Jasper, additional, Koechlin, Luca, additional, Ratmann, Paul David, additional, Strebel, Ivo, additional, Gehrke, Juliane, additional, Meier, Severin, additional, Walter, Joan, additional, Rubini Gimenez, Maria, additional, Mutschler, Eugenio, additional, Miró, Òscar, additional, López-Barbeito, Beatriz, additional, Martín-Sánchez, Francisco Javier, additional, Rodríguez-Adrada, Esther, additional, Keller, Dagmar I., additional, Newby, L. Kristin, additional, Twerenbold, Raphael, additional, Giannitsis, Evangelos, additional, Lindahl, Bertil, additional, Mueller, Christian, additional, Zimmermann, Tobias, additional, Schoepfer, Hadrien, additional, Coscia, Tania, additional, Troester, Valentina, additional, Reichlin, Tobias, additional, Kaeslin, Marina, additional, Christ, Michael, additional, Meier, Mario, additional, Badertscher, Patrick, additional, Puelacher, Christian, additional, du Fay de Lavallaz, Jeanne, additional, Potlukova, Eliska, additional, Kawecki, Damian, additional, Geigy, Nicolas, additional, Rentsch, Katharina, additional, Shrestha, Samyut, additional, Morawiec, Beata, additional, Munzk, Piotr, additional, Breidthardt, Tobias, additional, Freese, Michael, additional, Martinez-Nadal, Gemma, additional, Fuenzalida, Carolina, additional, Calderón, Sofia, additional, Rodriguez Adrada, Esther, additional, Ganovská, Eva, additional, Parenica, Jiri, additional, von Eckardstein, Arnold, additional, Campodarve, Isabel, additional, Gea, Joachim, additional, Mccord, James, additional, Nowak, Richard, additional, Body, Richard, additional, deFilippi, Christopher R., additional, Christenson, Robert H., additional, Panteghini, Mauro, additional, Plebani, Mario, additional, Verschuren, Franck, additional, French, John, additional, Weiser, Silvia, additional, and Jernberg, Tomas, additional

Published
2021
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20. Thirty-day outcomes in frail older patients discharged home from the emergency department with acute heart failure: effects of high-risk criteria identified by the DEED FRAIL-AHF trial

Author

Martín Sánchez, Francisco Javier, Parra Esquivel, Patricia, Llopis Garcia, Guillermo, Gonzalez del Castillo, Juan, Rodriguez Adrada, Esther, Espinosa, Begoña, López Diez, Maria Pilar, Romero Pareja, Rodolfo, Rizzi Bordigoni, Miguel Alberto, Pérez-Durá, Maria José, Bibiano, Carlos, Ferrer, Carles, Aguiló, Sira, Martín Mojarro, Enrique, Aguirre Tejedo, Alfons, Piñera, Pascual, López-Picado, Amanda, Llorens, Pere, Jacob, Javier, Gil, Víctor, Herrero Puente, Pablo, Fernandez Pérez, Cristina, Gil, Pedro, Calvo, Elpidio, Rossello, Xavier, Bueno, Hector, Burillo Putze, Guillermo, and Miró i Andreu, Òscar

Subjects
Aged, 80 and over, Heart Failure, Male, Acute heart failure., Aged., Anciano., Emergency department., Fragilidad., Frail elderly., Insuficiencia cardiaca aguda., Servicio de urgencias, Emergency department, Frail Elderly, Acute heart failure, Heart failure, Insuficiència cardíaca, Frail elderly, Persones grans, Patient Discharge, Serveis d'urgències hospitalàries, Acute Disease, Hospital emergency services, Humans, Female, Older people, Emergency Service, Hospital, Aged
Abstract

To study the effect of high-risk criteria on 30-day outcomes in frail older patients with acute heart failure (AHF) discharged from an emergency department (ED) or an ED's observation and short-stay areas.Secondary analysis of discharge records in the Older AHF Key Data registry. We selected frail patients (aged70 years) discharged with AHF from EDs. Risk factors were categorized as modifiable or nonmodifiable. The outcomes were a composite endpoint for a cardiovascular event (revisits for AHF, hospitalization for AHF, or cardiovascular death) and the number of days alive out-of-hospital (DAOH) within 30 days of discharge.We included 380 patients with a mean (SD) age of 86 (5.5) years (61.2% women). Modifiable risk factors were identified in 65.1%, nonmodifiable ones in 47.8%, and both types in 81.6%. The 30-day cardiovascular composite endpoint occurred in 83 patients (21.8%). The mean 30-day DAOH observed was 27.6 (6.1) days. Highrisk factors were present more often in patients who developed the cardiovascular event composite endpoint: the rates for patients with modifiable, nonmodifiable, or both types of risk were, respectively, as follows in comparison with patients not at high risk: 25.0% vs 17.2%, P = .092; 27.6% vs 16.7%, P = .010; and 24.7% vs 15.2%, P = .098). The 30-day DAOH outcome was also lower for at-risk patients, according to type of risk factor present: modifiable, 26.9 (7.0) vs 28.4 (4.4) days, P = .011; nonmodifiable, 27.1 (7.0) vs 28.0 (5.0) days, P = .127; and both, 27.1 (6.7) vs 28.8 (3.4) days, P = .005). After multivariate analysis, modifiable risk remained independently associated with fewer days alive (adjusted absolute difference in 30-day DAOH, -1.3 days (95% CI, -2.7 to -0.1 days). Nonmodifiable factors were associated with increased risk for the 30-day cardiovascular composite endpoint (adjusted absolute difference, 10.4%; 95% CI, -2.1% to 18.7%).Risk factors are common in frail elderly patients with AHF discharged home from hospital ED areas. Their presence is associated with a worse 30-day prognosis.Estudiar el efecto a 30 días de los criterios de alto riesgo (CAR) en los mayores frágiles con insuficiencia cardiaca aguda (ICA) dados de alta desde urgencias o unidades vinculadas (URG_UV).Análisis secundario del registro OAK-Discharge. Se seleccionaron pacientes frágiles 70 años con ICA dados de alta desde URG_UV. Los CAR se clasificaron en modificables (CAR_M) y no modificables (CAR_NM). Las variables de resultado fueron la compuesta cardiovascular (VC_CV) (revisita u hospitalización por ICA o mortalidad cardiovascular) y días vivos fuera del hospital (DVFH) a 30 días del alta.Se incluyeron 380 pacientes con una edad media de 86 (DE 5,5) años, 61,2% mujeres. Un 65,1% tuvo CAR_M, 47,8% CAR_NM y 81,6% ambos. Ochenta y tres pacientes (21,8%) presentaron la VC_CV a 30 días. La media de DVFH a 30 días fue de 27,6 (DE 6,1) días. La presencia de CAR modificable, no modificable o ambos, se asoció más frecuentemente a la VC_CV a 30 días (25,0% vs 17,2%, p = 0,092; 27,6% vs 16,7%, p = 0,010; 24,7% vs 15,2%, p = 0,098) y a menos DVFH a 30 días [26,9 (7,0) vs 28,4 (4,4), p = 0,011; 27,1 (7,0) vs 28,0 (5,0), p = 0,127; 27,1 (6,7) vs 28,8 (3,4), p = 0,005], respectivamente. Tras el análisis multivariante, los CAR_M se asociaron de forma independiente con menos DVFH a 30 días (diferencia absoluta ajustada –1,3 días; IC 95% –2,7 a –0,1) y los CAR_NM con más eventos en la VC_CV a 30 días (diferencia absoluta ajustada 10,4%; IC 95% 2,1% a 18,7%).Los CAR son frecuentes en los mayores frágiles con ICA dados de alta desde URG_UV y su presencia se asocia a peores resultados a 30 días tras alta.

Published
2021

21. Temporal distribution of emergency room visits in patients with migraine and other headaches

Author

García-Azorín, David, Abelaira-Freire, Jaime, Rodriguez-Adrada, Esther, González-García, Nuria, Planchuelo-Gómez, Álvaro, Guerrero, Ángel L., Porta-Etessam, Jesús, and Martín-Sánchez, Francisco J

Abstract

Background: Headache is a leading reason for presentation to the emergency department (ED) with migraine being the most frequently headache. To ensure the adequate staffing of healthcare providers during peak times of headache visits, we analyzed the temporal distribution of emergency department visits in patients presenting with headache and/or migraine. Research design and methods: The authors conducted an ecological study, including all consecutive visits to the ED for headache. Patients were classified according to the IHS Classification. We analyzed circadian, circaseptan and circannual patterns for number of visits, comparing migraine patients with other headache patients. Results: There were 2132 ED visits for headache, including primary headache in 1367 (64.1%) cases; migraine in 963 (45.2%); secondary headache in 404 (18.9%); and unspecified headache in 366 (17.1%). The circadian pattern showed peaks around 11:00–13:00 and 17:00–19:00, with visits during the night shift 45% less frequent (p < 0.001). The circaseptan pattern showed a peak on Monday-Tuesday and a low point on Sunday (p < 0.007). The circannual pattern peaked in March and decreased in June. Conclusions: ED visits for headache showed specific circadian, circaseptan and circannual variations. No differences were found in these patterns when comparing migraine patients to other headache patients.

Published
2021
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22. Novel Criteria for the Observe-Zone of the ESC 0/1 h-hs-cTnT Algorithm

Author

Lopez-Ayala, Pedro, Nestelberger, Thomas, Boeddinghaus, Jasper, Koechlin, Luca, Ratmann, Paul David, Strebel, Ivo, Gehrke, Juliane, Meier, Severin, Walter, Joan, Rubini Gimenez, Maria, Mutschler, Eugenio, Miro, Oscar, Lopez-Barbeito, Beatriz, Martin-Sanchez, Francisco Javier, Rodriguez-Adrada, Esther, Keller, Dagmar I., Newby, L. Kristin, Twerenbold, Raphael, Giannitsis, Evangelos, Lindahl, Bertil, Mueller, Christian, Lopez-Ayala, Pedro, Nestelberger, Thomas, Boeddinghaus, Jasper, Koechlin, Luca, Ratmann, Paul David, Strebel, Ivo, Gehrke, Juliane, Meier, Severin, Walter, Joan, Rubini Gimenez, Maria, Mutschler, Eugenio, Miro, Oscar, Lopez-Barbeito, Beatriz, Martin-Sanchez, Francisco Javier, Rodriguez-Adrada, Esther, Keller, Dagmar I., Newby, L. Kristin, Twerenbold, Raphael, Giannitsis, Evangelos, Lindahl, Bertil, and Mueller, Christian

Abstract

BACKGROUND: The non-ST-segment-elevation myocardial infarction (NSTEMI) guidelines of the European Society of Cardiology (ESC) recommend a 3h cardiac troponin determination in patients triaged to the observe-zone of the ESC 0/1h-algorithm; however, no specific cutoff for further triage is endorsed. Recently, a specific cutoff for 0/3h high-sensitivity cardiac troponin T (hs-cTnT) change (7 ng/L) was proposed, warranting external validation. METHODS: Patients presenting with acute chest discomfort to the emergency department were prospectively enrolled into an international multicenter diagnostic study. Final diagnoses were centrally adjudicated by 2 independent cardiologists applying the fourth universal definition of myocardial infarction, on the basis of complete cardiac workup, cardiac imaging, and serial hs-cTnT. Hs-cTnT concentrations were measured at presentation, after 1 hour, and after 3 hours. The objective was to externally validate the proposed cutoff, and if necessary, derive and internally as well as externally validate novel 0/3h-criteria for the observe-zone of the ESC 0/1h-hs-cTnT-algorithm in an independent multicenter cohort. RESULTS: Among 2076 eligible patients, application of the ESC 0/1h-hs-cTnT-algorithm triaged 1512 patients (72.8%) to either rule out or rule in NSTEMI, leaving 564 patients (27.2%) in the observe-zone (adjudicated NSTEMI prevalence, 120/564 patients, 21.3%). The suggested 0/3h-hs-cTnT-change of <7 ng/L triaged 517 patients (91.7%) toward rule-out, resulting in a sensitivity of 33.3% (95% CI, 25.5-42.2), missing 80 patients with NSTEMI, and >= 7 ng/L triaged 47 patients toward rule-in (8.3%), resulting in a specificity of 98.4% (95% CI, 96.8-99.2). Novel derived 0/3h-criteria for the observe-zone patients ruled out NSTEMI with a 3h hs-cTnT concentration <15 ng/L and a 0/3h-hs-cTnT absolute change <4 ng/L, triaging 138 patients (25%) toward rule-out, resulting in a sensitivity of 99.2% (95% CI, 96.0-99.9), missing 1

Published
2021
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23. External Validation of the No Objective Testing Rules in Acute Chest Pain

Author

Ratmann, Paul David, primary, Boeddinghaus, Jasper, additional, Nestelberger, Thomas, additional, Lopez‐Ayala, Pedro, additional, Koechlin, Luca, additional, Wildi, Karin, additional, Miro, Oscar, additional, Martín‐Sánchez, F. Javier, additional, Christ, Michael, additional, Twerenbold, Raphael, additional, Rubini Gimenez, Maria, additional, Keller, Dagmar I., additional, Mueller, Christian, additional, Troester, Valentina, additional, Meier, Mario, additional, Puelacher, Christian, additional, du Fay de Lavallaz, Jeanne, additional, Potlukova, Eliska, additional, Badertscher, Patrick, additional, Arslani, Ketina, additional, Freese, Michael, additional, Michou, Eleni, additional, Flores, Dayana, additional, Lohrmann, Jens, additional, Rentsch, Katharina, additional, Reichlin, Tobias, additional, López, Beatriz, additional, Fuenzalida, Carolina, additional, Rodriguez Adrada, Esther, additional, Ganovská, Eva, additional, Parenica, Jiri, additional, von Eckardstein, Arnold, additional, Morawiec, Beata, additional, Kawecki, Damian, additional, Muzyk, Piotr, additional, Bürgler, Franz, additional, and Geigy, Nicolas, additional

Published
2021
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25. Association of Previous Myocardial Infarction and Time to Presentation With Suspected Acute Myocardial Infarction

Author

Troester, Valentina, primary, Strebel, Ivo, additional, Nestelberger, Thomas, additional, Boeddinghaus, Jasper, additional, Rubini Gimenez, Maria, additional, Lopez‐Ayala, Pedro, additional, Koechlin, Luca, additional, Glarner, Noemi, additional, Prepoudis, Alexandra, additional, Miró, Òscar, additional, Martin‐Sanchez, F. Javier, additional, Kawecki, Damian, additional, Keller, Dagmar I., additional, Twerenbold, Raphael, additional, Mueller, Christian, additional, Walter, Joan, additional, Yufera Sanchez, Ana, additional, Puelacher, Christian, additional, du Fay de Lavallaz, Jeanne, additional, Shrestha, Samyut, additional, López, Beatriz, additional, Rodriguez Adrada, Esther, additional, Muzyk, Piotr, additional, Morawiec, Beata, additional, Lohrmann, Jens, additional, Christ, Michael, additional, Ratmann, Paul David, additional, Badertscher, Patrick, additional, Arslani, Ketina, additional, Zimmermann, Tobias, additional, Freese, Michael, additional, Wildi, Karin, additional, Wussler, Desiree, additional, Gualandro, Danielle M, additional, Frey, Simon, additional, and Geigy, Nicolas, additional

Published
2021
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26. Circadian, weekly, seasonal, and temperature-dependent patterns of syncope aetiology in patients at increased risk of cardiac syncope

Author

du Fay de Lavallaz, Jeanne, Badertscher, Patrick, Nestelberger, Thomas, Flores, Dayana, Miró, Òscar, Salgado, Emilio, Geigy, Nicolas, Christ, Michael, Cullen, Louise, Than, Martin, Martin-Sanchez, F Javier, Rodriguez-Adrada, Esther, Di Somma, Salvatore, Peacock, W Frank, Kawecki, Damian, Boeddinghaus, Jasper, Twerenbold, Raphael, Puelacher, Christian, Wussler, Desiree, Strebel, Ivo, Keller, Dagmar I, Poepping, Imke, Kühne, Michael, Reichlin, Tobias, Mueller, Christian, BASEL IX Investigators, University of Zurich, and Mueller, Christian

Subjects
2737 Physiology (medical), 540 Chemistry, 610 Medicine & health, 2705 Cardiology and Cardiovascular Medicine, 10038 Institute of Clinical Chemistry
Published
2019

27. Patients with acute heart failure discharged from the emergency department and classified as low risk by the MEESSI score (multiple risk estimate based on the Spanish emergency department scale): prevalence of adverse events and predictability

Author

Miro, Oscar, Gil, Victor, Rossello, Xavier, Javier Martin-Sanchez, Francisco, Llorens, Pere, Jacob, Javier, Herrero, Pablo, Herrera Mateo, Sergio, Richard, Fernando, Escoda, Rosa, Fuentes, Marta, Martin Mojarro, Enrique, Llauger, Lluis, HECTOR BUENO, Pocock, Stuart, Gil, Cristina, Garmila, Pablo, Rodriguez Adrada, Esther, Perdigones, Javier, Escobar, Luis, Xipell, Carolina, Sanchez, Carolina, Ma Gaytan, Josep, Jose Perez-Dura, Maria, Pavon, Jose, Bella Alvarez, Ana, Noval, Antonio, Torres, Jose M., Luisa Lopez-Grima, Maria, Valero, Amparo, Angeles Juan, Marian, Aguirre, Alfons, Angels Pedragosa, Maria, Isabel Alonso, Maria, Ruiz, Francisco, Miguel Franco, Jose, Diaz, Elena, Belen Mecina, Ana, Tost, Josep, Sanchez, Susana, Pinera, Pascual, Torres Garate, Raquel, Alberto Rizzi, Miguel, Herrera, Sergio, Cabello, Irene, Alvarez Perez, Jose Maria, Lopez Diez, Maria Pilar, Vasquez Alvarez, Joaquin, Alonso Morilla, Ana, Irimia, Andrea, Marquina, Victor, Jimenez, Inmaculada, Hernandez, Nestor, Ramos, Sergio, Lopez, Ana, Antonio Andueza, Juan, Romero, Rodolfo, Calvache, Roberto, Teresa Lorca, Maria, Calderon, Luis, Amores Arriaga, Beatriz, Sierra, Beatriz, Traver Becquer, Lisette, Corominas La Salle, Gerard, Aguera Urbano, Carmen, and Soy Ferrer, Ester

Subjects
Hospitalization, Emergency department, Acute heart failure, Mortality, Emergency revisits, Risk assessment
Abstract

Objective. To determine the rate of adverse events in patients with acute heart failure (AHF) who were discharged from the emergency department (ED) after classification as low risk according to MEESSI score (multiple risk estimate based on the Spanish ED scale), to analyze the ability of the score to predict events, and to explore variables associated with adverse events. Methods. Patients in the EAHFE registry (Epidemiology of Acute Heart Failure in EDs) were stratified according to risk indicated by MEESSI score in order to identify those considered at low risk on discharge. All-cause 30-day mortality and revisits related to AHF within 7 days and 30 days were recorded. The area under the receiver operating characteristic curve (AUC) was calculated for the MEESSI score's ability to predict these events. Associations between 42 variables and 7-day and 30-day revisits to the ED were analyzed by multivariable logistic regression. Results. A total of 1028 patients were included. The 30-day mortality rate was 1.6% (95% CI, 0.9%-2.5%). The 7-day and 30-day revisit rates were 8.0% (95% CI, 6.4%-9.8%) and 24.7% (95% CI, 22.1%-25.7%), respectively. The AUCs for MEESSI score discrimination between patients with and without these outcomes were as follows: 30-day mortality, 0.69 (95% CI, 0.58-0.80); 7-day revisiting, 0.56 (95% CI, 0.49-0.63); and 30-day revisiting, 0.54 (95% CI, 0.50-0.59). Variables associated with 7-day revisits were long-term diuretic treatment (odds ratio [OR], 2.45; 95% CI, 1.01-5.98), hemoglobin concentration less than 110 g/L (OR, 1.68; 95% CI, 1.02-2.75), and intravenous diuretic treatment in the ED (OR, 0.53; 95% CI, 0.31-0.90). Variables associated with 30-day revisits were peripheral artery disease (OR, 1.74; 95% CI, 1.01-3.00), prior history of an AHF episode (OR, 1.42; 95% CI, 1.02-1.98), long-term mineralocorticoid receptor antagonist treatment (OR, 1.71; 95% CI, 1.09-2.67), Barthel index less than 90 points in the ED (OR, 1.48; 95% CI, 1.07-2.06), and intravenous diuretic treatment in the ED (OR, 0.58; 95% CI, 0.40-0.84). Conclusions. Patients with AHF who are at low risk for adverse events on discharge from our EDs have event rates that are near internationally recommended targets. The MEESSI score, which was designed to predict 30-day mortality, is a poor predictor of 7-day or 30-day revisiting in these low-risk patients. We identified other factors related to these events.

Published
2019

28. Clinical phenotypes of acute heart failure based on signs and symptoms of perfusion and congestion at emergency department presentation and their relationship with patient management and outcomes

Author

Javaloyes, Patricia Miro, Oscar Gil, Victor Javier Martin-Sanchez, Francisco Jacob, Javier Herrero, Pablo and Takagi, Koji Alquezar-Arbe, Aitor Lopez Diez, Maria Pilar and Martin, Enrique Bibiano, Carlos Escoda, Rosa Gil, Cristina and Fuentes, Marta Llopis Garcia, Guillermo Alvarez Perez, Jose Maria Jerez, Alba Tost, Josep Llauger, Lluis Romero, Rodolfo Manuel Garrido, Jose Rodriguez-Adrada, Esther and Sanchez, Carolina Rossello, Xavier Parissis, John Mebazaa, Alexandre Chioncel, Ovidiu Llorens, Pere Alonso, Hector and Perez-Llantada, Enrique Suarez Cadenas, Mar Xipell, Carolina and Jose Perez-Dura, Maria Salvo, Eva Pavon, Jose Noval, Antonio and Manuel Torres, Jose Luisa Lopez-Grima, Maria Valero, Amparo and Angeles Juan, Maria Aguirre, Alfons Angels Pedragosa, Maria and Minguez Maso, Silvia Isabel Alonso, Maria Ruiz, Francisco and Miguel Franco, Jose Belen Mecina, Ana Berenguer, Marta and Donea, Ruxandra Sanchez Ramon, Susana Carbajosa Rodriguez, Virginia Pinera, Pascual Sanchez Nicolas, Jose Andres Torres Garate, Raquel Alberto Rizzi, Miguel Roset, Alex Cabello, Irene Haro, Antonio Richard, Fernando Lopez Diez, Maria Pilar Vazquez Alvarez, Joaquin Prieto Garcia, Belen Garcia Garcia, Maria Sanchez Gonzalez, Marta Marquina, Victor and Jimenez, Inmaculada Hernandez, Nestor Brouzet, Benjamin and Espinosa, Begona Antonio Andueza, Juan Ruiz, Martin and Calvache, Roberto Lorca Serralta, Maria Teresa Calderon Jave, Luis Ernesto Amores Arriaga, Beatriz Sierra Bergua, Beatriz and Martin Mojarro, Enrique Alarcon Jimenez, Brigitte Silvana and Traveria Becquer, Lisette Burillo, Guillermo Llauger Garcia, Lluis Corominas LaSalle, Gerard Aguera Urbano, Carmen Garcia Soto, Ana Belen Delgado Padial, Elisa Soy Ferrer, Ester and Javier Lucas-Imbernon, Francisco Gaya, Rut Mir, Maria and Rodriguez, Beatriz Luis Carballo, Jose Rodriguez Miranda, Belen and ICA-SEMES Res Grp

Abstract

Objective To compare the clinical characteristics and outcomes of patients with acute heart failure (AHF) according to clinical profiles based on congestion and perfusion determined in the emergency department (ED). Methods and results Overall, 11 261 unselected AHF patients from 41 Spanish EDs were classified according to perfusion (normoperfusion = warm; hypoperfusion = cold) and congestion (not = dry; yes = wet). Baseline and decompensation characteristics were recorded as were the main wards to which patients were admitted. The primary outcome was 1-year all-cause mortality; secondary outcomes were need for hospitalisation during the index AHF event, in-hospital all-cause mortality, prolonged hospitalisation, 7-day post-discharge ED revisit for AHF and 30-day post-discharge rehospitalisation for AHF. A total of 8558 patients (76.0%) were warm+ wet, 1929 (17.1%) cold+ wet, 675 (6.0%) warm+ dry, and 99 (0.9%) cold+ dry; hypoperfused (cold) patients were more frequently admitted to intensive care units and geriatrics departments, and warm+ wet patients were discharged home without admission. The four phenotypes differed in most of the baseline and decompensation characteristics. The 1-year mortality was 30.8%, and compared to warm+ dry, the adjusted hazard ratios were significantly increased for cold+ wet (1.660; 95% confidence interval 1.400-1.968) and cold+ dry (1.672; 95% confidence interval 1.189-2.351). Hypoperfused (cold) phenotypes also showed higher rates of index episode hospitalisation and in-hospital mortality, while congestive (wet) phenotypes had a higher risk of prolonged hospitalisation but decreased risk of rehospitalisation. No differences were observed among phenotypes in ED revisit risk. Conclusions Bedside clinical evaluation of congestion and perfusion of AHF patients upon ED arrival and classification according to phenotypic profiles proposed by the latest European Society of Cardiology guidelines provide useful complementary information and help to rapidly predict patient outcomes shortly after ED patient arrival.

Published
2019

29. Two-Hour Algorithm for Rapid Triage of Suspected Acute Myocardial Infarction Using a High-Sensitivity Cardiac Troponin I Assay

Author

Nestelberger, Thomas, primary, Boeddinghaus, Jasper, additional, Greenslade, Jaimi, additional, Parsonage, William A, additional, Than, Martin, additional, Wussler, Desiree, additional, Lopez-Ayala, Pedro, additional, Zimmermann, Tobias, additional, Meier, Mario, additional, Troester, Valentina, additional, Badertscher, Patrick, additional, Koechlin, Luca, additional, Wildi, Karin, additional, Anwar, Mahnoor, additional, Freese, Michael, additional, Keller, Dagmar I, additional, Reichlin, Tobias, additional, Twerenbold, Raphael, additional, Cullen, Louise, additional, Mueller, Christian, additional, Puelacher, Christian, additional, du Fay de Lavallaz, Jeanne, additional, Rubini Giménez, Maria, additional, Strebel, Ivo, additional, Walter, Joan, additional, Huber, Jeffrey, additional, Christ, Michael, additional, Kozhuharov, Nikola, additional, Gualandro, Danielle M, additional, Potlukova, Eliska, additional, Baumgartner, Benjamin, additional, Hafner, Benjamin, additional, Rentsch, Katharina, additional, Miró, Òscar, additional, Fuenzalida, Carolina, additional, Gil, Beatriz, additional, Martin-Sanchez, F Javier, additional, Kawecki, Damian, additional, Geigy, Nicolas, additional, Meissner, Kathrin, additional, Kulangara, Caroline, additional, López, Beatriz, additional, Rodriguez Adrada, Esther, additional, Ganovská, Eva, additional, Lohrmann, Jens, additional, Kloos, Wanda, additional, Steude, Jana, additional, Buser, Andreas, additional, von Eckardstein, Arnold, additional, Nowalany-Kozielska, Ewa, additional, and Muzyk, Piotr, additional

Published
2019
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30. Clinical Use of a New High-Sensitivity Cardiac Troponin I Assay in Patients with Suspected Myocardial Infarction

Author

Boeddinghaus, Jasper, primary, Twerenbold, Raphael, additional, Nestelberger, Thomas, additional, Koechlin, Luca, additional, Wussler, Desiree, additional, Meier, Mario, additional, Troester, Valentina, additional, Zimmermann, Tobias, additional, Badertscher, Patrick, additional, Wildi, Karin, additional, Rubini Giménez, Maria, additional, Lopez-Ayala, Pedro, additional, Potlukova, Eliska, additional, Miró, Òscar, additional, Martin-Sanchez, F Javier, additional, Kawecki, Damian, additional, Geigy, Nicolas, additional, Keller, Dagmar I, additional, Reichlin, Tobias, additional, Mueller, Christian, additional, du Fay de Lavallaz, Jeanne, additional, Walter, Joan Elias, additional, Freese, Michael, additional, Puelacher, Christian, additional, Hafner, Benjamin, additional, Strebel, Ivo, additional, Kozhuharov, Nikola, additional, Rentsch, Katharina, additional, Gualandro, Danielle M, additional, Schaerli, Nicolas, additional, Stelzig, Claudia, additional, Meissner, Kathrin, additional, Kulangara, Caroline, additional, Hillinger, Petra, additional, Grimm, Karin, additional, Michou, Eleni, additional, Flores, Dayana, additional, Czmok, Rafael, additional, Osswald, Stefan, additional, López, Beatriz, additional, Fuenzalida, Carolina, additional, Rodriguez Adrada, Esther, additional, Ganovská, Eva, additional, Lohrmann, Jens, additional, Kloos, Wanda, additional, Christ, Michael, additional, Steude, Jana, additional, Fahrni, Gregor, additional, Buser, Andreas, additional, von Eckardstein, Arnold, additional, Morawiec, Beata, additional, Nowalany-Kozielska, Ewa, additional, and Muzyk, Piotr, additional

Published
2019
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31. Circadian, weekly, seasonal, and temperature-dependent patterns of syncope aetiology in patients at increased risk of cardiac syncope.

Author

Lavallaz, Jeanne du Fay de, Badertscher, Patrick, Nestelberger, Thomas, Flores, Dayana, Miró, Òscar, Salgado, Emilio, Geigy, Nicolas, Christ, Michael, Cullen, Louise, Than, Martin, Martin-Sanchez, F Javier, Rodriguez-Adrada, Esther, Somma, Salvatore Di, Peacock, W Frank, Kawecki, Damian, Boeddinghaus, Jasper, Twerenbold, Raphael, Puelacher, Christian, Wussler, Desiree, and Strebel, Ivo

Abstract

Aims: It is unknown whether cardiac syncope, and possibly also other syncope aetiologies exhibit circadian, weekly, seasonal, and temperature-dependent patterns.Methods and Results: We prospectively recorded the exact time, date, and outside temperature of syncope of patients >40 years old presenting with syncope to the emergency department in a diagnostic multicentre study. Two independent cardiologists/emergency physicians adjudicated the final diagnosis based on all information becoming available during clinical work-up including 1-year follow-up. Among 1230 patients, the adjudicated aetiology was cardiac in 14.6%, reflex in 39.2%, orthostatic in 25.7%, other non-cardiac in 9.7%, and unknown in 10.8% of patients. All syncope aetiologies occurred much more frequently during the day when compared with the night (P < 0.01). While reflex and orthostatic syncope showed a broad peak of prevalence with 80.9% of these events occurring between 4 am and 4 pm, cardiac syncope showed a narrow peak of prevalence with 70.1% of all events occurring between 8 am and 2 pm. A weekly pattern was present for most syncope aetiologies, with events occurring mainly from Monday to Friday (P < 0.01). Reflex syncope displayed a seasonal rhythm and was more common in winter (P < 0.01), while cardiac syncope stayed constant over the year. Syncope occurred most often when the outside temperature was coldest. Overall the patterns observed for cardiac syncope were similar to the patterns observed for its differential diagnosis.Conclusion: Syncope aetiologies in patients >40 years old display circadian, weekly, seasonal, and temperature-dependent patterns. Unfortunately, these patterns do not allow to reliably differentiate cardiac syncope from other aetiologies. [ABSTRACT FROM AUTHOR]

Published
2019
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38. Circadian, weekly, seasonal, and temperature-dependent patterns of syncope aetiology in patients at increased risk of cardiac syncope.

Author

du Fay de Lavallaz J, Badertscher P, Nestelberger T, Flores D, Miró Ò, Salgado E, Geigy N, Christ M, Cullen L, Than M, Martin-Sanchez FJ, Rodriguez-Adrada E, Di Somma S, Peacock WF, Kawecki D, Boeddinghaus J, Twerenbold R, Puelacher C, Wussler D, Strebel I, Keller DI, Poepping I, Kühne M, Reichlin T, and Mueller C

Subjects
Adult, Aged, Aged, 80 and over, Australia epidemiology, Europe epidemiology, Female, Humans, Male, Middle Aged, New Zealand epidemiology, Prevalence, Prospective Studies, Risk Factors, Syncope diagnosis, Syncope physiopathology, Time Factors, United States epidemiology, Circadian Rhythm, Seasons, Syncope epidemiology, Temperature
Abstract

Aims: It is unknown whether cardiac syncope, and possibly also other syncope aetiologies exhibit circadian, weekly, seasonal, and temperature-dependent patterns., Methods and Results: We prospectively recorded the exact time, date, and outside temperature of syncope of patients >40 years old presenting with syncope to the emergency department in a diagnostic multicentre study. Two independent cardiologists/emergency physicians adjudicated the final diagnosis based on all information becoming available during clinical work-up including 1-year follow-up. Among 1230 patients, the adjudicated aetiology was cardiac in 14.6%, reflex in 39.2%, orthostatic in 25.7%, other non-cardiac in 9.7%, and unknown in 10.8% of patients. All syncope aetiologies occurred much more frequently during the day when compared with the night (P < 0.01). While reflex and orthostatic syncope showed a broad peak of prevalence with 80.9% of these events occurring between 4 am and 4 pm, cardiac syncope showed a narrow peak of prevalence with 70.1% of all events occurring between 8 am and 2 pm. A weekly pattern was present for most syncope aetiologies, with events occurring mainly from Monday to Friday (P < 0.01). Reflex syncope displayed a seasonal rhythm and was more common in winter (P < 0.01), while cardiac syncope stayed constant over the year. Syncope occurred most often when the outside temperature was coldest. Overall the patterns observed for cardiac syncope were similar to the patterns observed for its differential diagnosis., Conclusion: Syncope aetiologies in patients >40 years old display circadian, weekly, seasonal, and temperature-dependent patterns. Unfortunately, these patterns do not allow to reliably differentiate cardiac syncope from other aetiologies., (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2018. For permissions, please email: journals.permissions@oup.com.)

Published
2019
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