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Your search keyword '"Rodríguez-Álvarez, M.J."' showing total 9 results
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9 results on '"Rodríguez-Álvarez, M.J."'

4. Simulation Study for Designing a Dedicated Cardiac TOF-PET System

Author

Universitat Politècnica de València. Instituto de Instrumentación para Imagen Molecular - Institut d'Instrumentació per a Imatge Molecular, Universitat Politècnica de València. Departamento de Matemática Aplicada - Departament de Matemàtica Aplicada, European Commission, Generalitat Valenciana, Agencia Estatal de Investigación, European Regional Development Fund, Oliver-Gil, Sandra, Moliner, L., Ilisie, V., Benlloch Baviera, Jose María, Rodríguez-Álvarez, M.J., Universitat Politècnica de València. Instituto de Instrumentación para Imagen Molecular - Institut d'Instrumentació per a Imatge Molecular, Universitat Politècnica de València. Departamento de Matemática Aplicada - Departament de Matemàtica Aplicada, European Commission, Generalitat Valenciana, Agencia Estatal de Investigación, European Regional Development Fund, Oliver-Gil, Sandra, Moliner, L., Ilisie, V., Benlloch Baviera, Jose María, and Rodríguez-Álvarez, M.J.

Abstract

[EN] The development of dedicated positron emission tomography scanners is an active area of research, especially aiming at the improvement of lesion detection and in support of cancer treatment and management. Recently, dedicated Positron Emission Tomography (PET) systems with different configurations for specific organs have been developed for improving detection effectiveness. Open geometries are always subject to distortion and artifacts in the reconstructed images. Therefore, the aim of this work is to determine the optimal geometry for a novel cardiac PET system that will be developed by our team, and determine the time resolution needed to achieve reasonable image quality for the chosen geometry. The proposed geometries consist of 36 modules. These modules are arranged in two sets of two plates, each one with different configurations. We performed Monte Carlo simulations with different TOF resolutions, in order to test the image quality improvement in each case. Our results show, as expected, that increasing TOF resolution reduces distortion and artifact effects. We can conclude that a TOF resolution of the order of 200 ps is needed to reduce the artifacts, to acceptable levels, generated in the simulated cardiac-PET open geometries.

Published
2020

6. Magnetic resonance brain images algorithm to identify demyelinating and ischemic diseases

Author

Universitat Politècnica de València. Departamento de Matemática Aplicada - Departament de Matemàtica Aplicada, Castillo-Malla, Darwin Patricio, Samaniego, R., Jimenez, Y., Cuenca, L., Vivanco, O., Rodríguez-Álvarez, M.J., Universitat Politècnica de València. Departamento de Matemática Aplicada - Departament de Matemàtica Aplicada, Castillo-Malla, Darwin Patricio, Samaniego, R., Jimenez, Y., Cuenca, L., Vivanco, O., and Rodríguez-Álvarez, M.J.

Abstract

[EN] Brain demyelination lesions occur due to damage of the myelin layer of nerve fibers, this deterioration is the cause of pathologies such as multiple sclerosis, leukodystrophy, encephalomyelitis. Brain ischemia is the interruption of the blood supply to the brain, and the flow of oxygen and nutrients needed to maintain the correct functioning of brain cells. This project presents the results of an algorithm processing images with the the main objective of identify and differentiate between demyelination and ischemic brain diseases through the automatic detection, classification and identification of their features found in the magnetic resonance images. The sequences of images used were T1, T2, and FLAIR and with a dataset of 300 patients with and without these or other pathologies, respectively. The algorithm in this stage uses Discrete Wavelet Transform (DWT), principal component analysis (PCA) and a kernel support vector machine (SVM). The algorithm developed indicates a 75% of accuracy, for that reason, with an effective validation could be applied for the fast diagnosis and contribute to an effective treatment of these brain diseases especially in the rural places.

Published
2018

7. Building blocks of a multi-layer PET with time sequence photon interaction discrimination and double Compton camera

Author

Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes, Universitat Politècnica de València. Instituto de Instrumentación para Imagen Molecular - Institut d'Instrumentació per a Imatge Molecular, Universitat Politècnica de València. Departamento de Matemática Aplicada - Departament de Matemàtica Aplicada, Ministerio de Economía y Competitividad, European Commission, Ilisie, V., Giménez-Alventosa, Vicent, Moliner Martínez, Laura, Sánchez, F., González Martínez, Antonio Javier, Rodríguez-Álvarez, M.J., Benlloch Baviera, Jose María, Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes, Universitat Politècnica de València. Instituto de Instrumentación para Imagen Molecular - Institut d'Instrumentació per a Imatge Molecular, Universitat Politècnica de València. Departamento de Matemática Aplicada - Departament de Matemàtica Aplicada, Ministerio de Economía y Competitividad, European Commission, Ilisie, V., Giménez-Alventosa, Vicent, Moliner Martínez, Laura, Sánchez, F., González Martínez, Antonio Javier, Rodríguez-Álvarez, M.J., and Benlloch Baviera, Jose María

Abstract

[EN] Current PET detectors have a very low sensitivity, of the order of a few percent. One of the reasons is the fact that Compton interactions are rejected. If an event involves multiple Compton scattering and the total deposited energy lays within the photoelectric peak, then an energy-weighted centroid is the given output for the coordinates of the reconstructed interaction point. This introduces distortion in the final reconstructed image. The aim of our work is to prove that Compton events are a very rich source of additional information as one can improve the resolution of the detector and implicitly the final reconstructed image. This could be a real breakthrough for PET detector technology as one should be able to obtain better results with less patient radiation. Using a PET as a double Compton camera, by means of Compton cone matching i.e., Compton cones coming from the same event should be compatible, is applied to discard randoms, patient scattered events and also, to perform a correct matching among events with multiple coincidences. In order to fully benefit experimentally from Compton events using monolithic scintillators a multi-layer configuration is needed and a good time-of-flight resolution.

Published
2018

8. Characterization of protons accelerated from a 3 TW table-top laser system

Author

Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes, Universitat Politècnica de València. Instituto de Instrumentación para Imagen Molecular - Institut d'Instrumentació per a Imatge Molecular, Universitat Politècnica de València. Departamento de Matemática Aplicada - Departament de Matemàtica Aplicada, Ministerio de Economía y Competitividad, Centro para el Desarrollo Tecnológico Industrial, Bellido-Millán, Pablo Jesús, Lera, Roberto, Seimetz, Michael, Ruiz-de la Cruz, Alexandro, Torres Peiró, Salvador, Galán, M., Mur, P., Sánchez, I., Zaffino, R., Vidal San Sebastian, Luis Fernando, Soriano Asensi, Antonio, Sánchez-Góez, Sebastián, Sánchez Martínez, Filomeno, Rodríguez-Álvarez, M.J., Rigla, J.P., Moliner Martínez, Laura, Iborra Carreres, Amadeo, Hernández Hernández, Liczandro, Grau-Ruiz, Daniel, González Martínez, Antonio Javier, García-Garrigos, Juan José, Díaz Caballero, Elena, Conde-Castellanos, Pablo Eloy, Aguilar-Talens, Albert, Roso, Luis, Benlloch Baviera, Jose María, Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes, Universitat Politècnica de València. Instituto de Instrumentación para Imagen Molecular - Institut d'Instrumentació per a Imatge Molecular, Universitat Politècnica de València. Departamento de Matemática Aplicada - Departament de Matemàtica Aplicada, Ministerio de Economía y Competitividad, Centro para el Desarrollo Tecnológico Industrial, Bellido-Millán, Pablo Jesús, Lera, Roberto, Seimetz, Michael, Ruiz-de la Cruz, Alexandro, Torres Peiró, Salvador, Galán, M., Mur, P., Sánchez, I., Zaffino, R., Vidal San Sebastian, Luis Fernando, Soriano Asensi, Antonio, Sánchez-Góez, Sebastián, Sánchez Martínez, Filomeno, Rodríguez-Álvarez, M.J., Rigla, J.P., Moliner Martínez, Laura, Iborra Carreres, Amadeo, Hernández Hernández, Liczandro, Grau-Ruiz, Daniel, González Martínez, Antonio Javier, García-Garrigos, Juan José, Díaz Caballero, Elena, Conde-Castellanos, Pablo Eloy, Aguilar-Talens, Albert, Roso, Luis, and Benlloch Baviera, Jose María

Abstract

[EN] We report on benchmark tests of a 3 TW/50 fs, table-top laser system specifically developed for proton acceleration with an intrinsic pump rate up to 100 Hz. In two series of single-shot measurements differing in pulse energy and contrast the successful operation of the diode pumped laser is demonstrated. Protons have been accelerated up to 1.6 MeV in interactions of laser pulses focused on aluminium and mylar foils between 0.8 and 25 mu m thickness. Their spectral distributions and maximum energies are consistent with former experiments under similar conditions. These results show the suitability of our system and provide a reference for studies of laser targets at high repetition rate and possible applications.

Published
2017

9. Characterization of protons accelerated from a 3 TW table-top laser system

Author

Bellido, P., primary, Lera, R., additional, Seimetz, M., additional, Cruz, A. Ruiz-de la, additional, Torres-Peirò, S., additional, Galán, M., additional, Mur, P., additional, Sánchez, I., additional, Zaffino, R., additional, Vidal, L., additional, Soriano, A., additional, Sánchez, S., additional, Sánchez, F., additional, Rodríguez-Álvarez, M.J., additional, Rigla, J.P., additional, Moliner, L., additional, Iborra, A., additional, Hernández, L., additional, Grau-Ruiz, D., additional, González, A.J., additional, García-Garrigos, J.J., additional, Díaz-Caballero, E., additional, Conde, P., additional, Aguilar, A., additional, Roso, L., additional, and Benlloch, J.M., additional

Published
2017
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