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31 results on '"Roche, Sandra"'

9. Preclinical evaluation of Insulin-like growth factor receptor 1 (IGF1R) and Insulin Receptor (IR) as a therapeutic targets in triple negative breast cancer

Author

Roche, Sandra, primary, Gaule, Patricia, additional, Winrow, Deirdre, additional, Mukherjee, Nupur, additional, O’Neill, Fiona, additional, Conlon, Neil T., additional, Meiller, Justine, additional, Collins, Denis M., additional, Canonici, Alexandra, additional, Fawsi, Mohammed Ibrahim, additional, Estepa-Fernández, Alejandra, additional, Madden, Stephen F., additional, Crown, John, additional, O’Donovan, Norma, additional, and Eustace, Alex J., additional

Published
2023
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10. Alteration in Levels of Specific miRNAs and Their Potential Protein Targets between Human Pancreatic Cancer Samples, Adjacent Normal Tissue, and Xenografts Derived from These Tumors

Author

O’Neill, Fiona, primary, Allen-Coyle, Taylor-Jade, additional, Roche, Sandra, additional, Meiller, Justine, additional, Conlon, Neil T., additional, Swan, Niall, additional, Straubinger, Robert M., additional, Geoghegan, Justin, additional, Straubinger, Ninfa L., additional, Conlon, Kevin, additional, McDermott, Ray, additional, O’Sullivan, Finbarr, additional, Henry, Michael, additional, Meleady, Paula, additional, McVey, Gerard, additional, O’Connor, Robert, additional, Moriarty, Michael, additional, and Clynes, Martin, additional

Published
2023
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11. Pancreatic Cancer 3D Cell Line Organoids (CLOs) Maintain the Phenotypic Characteristics of Organoids and Accurately Reflect the Cellular Architecture and Heterogeneity In Vivo

Author

Noorani, Sara, primary, Nelson, Shannon R., additional, Conlon, Neil T., additional, Meiller, Justine, additional, Shcheglova, Ekaterina, additional, Usai, Alice, additional, Stoof, Jojanneke, additional, Palanga, Letizia, additional, O’Neill, Fiona, additional, Roche, Sandra, additional, Cotter, Maura B., additional, Swan, Niall, additional, and Walsh, Naomi, additional

Published
2022
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13. Alteration in Levels of Specific miRNAs and Their Potential Protein Targets between Human Pancreatic Cancer Samples, Adjacent Normal Tissue, and Xenografts Derived from These Tumors.

Author

O'Neill, Fiona, Allen-Coyle, Taylor-Jade, Roche, Sandra, Meiller, Justine, Conlon, Neil T., Swan, Niall, Straubinger, Robert M., Geoghegan, Justin, Straubinger, Ninfa L., Conlon, Kevin, McDermott, Ray, O'Sullivan, Finbarr, Henry, Michael, Meleady, Paula, McVey, Gerard, O'Connor, Robert, Moriarty, Michael, and Clynes, Martin

Subjects
PANCREATIC cancer, MICRORNA, PROTEINS, PANCREATIC tumors, XENOGRAFTS
Abstract

Herein, we describe the global comparison of miRNAs in human pancreatic cancer tumors, adjacent normal tissue, and matched patient-derived xenograft models using microarray screening. RNA was extracted from seven tumor, five adjacent normal, and eight FI PDX tumor samples and analyzed by Affymetrix GeneChip miRNA 4.0 array. A transcriptome analysis console (TAC) was used to generate comparative lists of up- and downregulated miRNAs for the comparisons, tumor vs. normal and F1 PDX vs. tumor. Particular attention was paid to miRNAs that were changed in the same direction in both comparisons. We identified the involvement in pancreatic tumor tissue of several miRNAs, including miR4534, miR3154, and miR4742, not previously highlighted as being involved in this type of cancer. Investigation in the parallel mRNA and protein lists from the same samples allowed the elimination of proteins where altered expression correlated with corresponding mRNA levels and was thus less likely to be miRNA regulated. Using the remaining differential expression protein lists for proteins predicted to be targeted for differentially expressed miRNA on our list, we were able to tentatively ascribe specific protein changes to individual miRNA. Particularly interesting target proteins for miRs 615-3p, 2467-3p, 4742-5p, 509-5p, and 605-3p were identified. Prominent among the protein targets are enzymes involved in aldehyde metabolism and membrane transport and trafficking. These results may help to uncover vulnerabilities that could enable novel approaches to treating pancreatic cancer. [ABSTRACT FROM AUTHOR]

Published
2023
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14. Genomic Profiling and Functional Analysis of let-7c miRNA-mRNA Interactions Identify SOX13 to Be Involved in Invasion and Progression of Pancreatic Cancer

Author

Nelson, Shannon R., primary, Roche, Sandra, additional, Cotter, Maura, additional, Garcia, Pablo Anton, additional, Reitmeier, Daniela, additional, Zollbrecht, Elisabeth, additional, O’Neill, Fiona, additional, Clynes, Martin, additional, Doolan, Padraig, additional, Mehta, Jai P., additional, Swan, Niall, additional, Larkin, AnneMarie, additional, and Walsh, Naomi, additional

Published
2020
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16. Cover Feature: Polypyridyl‐Based Copper Phenanthrene Complexes: Combining Stability with Enhanced DNA Recognition (Chem. Eur. J. 3/2021)

Author

Fantoni, Nicoló Zuin, primary, Molphy, Zara, additional, O'Carroll, Sinéad, additional, Menounou, Georgia, additional, Mitrikas, George, additional, Krokidis, Marios G., additional, Chatgilialoglu, Chryssostomos, additional, Colleran, John, additional, Banasiak, Anna, additional, Clynes, Martin, additional, Roche, Sandra, additional, Kelly, Suainibhe, additional, McKee, Vickie, additional, and Kellett, Andrew, additional

Published
2020
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17. Polypyridyl‐Based Copper Phenanthrene Complexes: Combining Stability with Enhanced DNA Recognition

Author

Fantoni, Nicoló Zuin, primary, Molphy, Zara, additional, O'Carroll, Sinéad, additional, Menounou, Georgia, additional, Mitrikas, George, additional, Krokidis, Marios G., additional, Chatgilialoglu, Chryssostomos, additional, Colleran, John, additional, Banasiak, Anna, additional, Clynes, Martin, additional, Roche, Sandra, additional, Kelly, Suainibhe, additional, McKee, Vickie, additional, and Kellett, Andrew, additional

Published
2020
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18. Abstract 1678: Establishment and characterization by expression microarrays of a patient-derived xenograft biobank for human pancreatic adenocarcinoma

Author

Roche, Sandra, primary, O'Neill, Fiona, additional, Swan, Niall, additional, Straubinger, Ninfa L., additional, Conlon, Neil T., additional, Murphy, Jean, additional, Conlon, Kevin, additional, McDermott, Ray, additional, Meiller, Justine, additional, Geoghegan, Justin, additional, Moriarty, Michael, additional, Straubinger, Robert M., additional, and Clynes, Martin, additional

Published
2020
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19. Additional_File_1___Cell_line_authentication – Supplemental material for Combined targeting EGFR and SRC as a potential novel therapeutic approach for the treatment of triple negative breast cancer

Author

Canonici, Alexandra, Alacoque L. Browne, Ibrahim, Mohamed F. K., Fanning, Kevin P., Roche, Sandra, Conlon, Neil T., O’Neill, Fiona, Meiller, Justine, Cremona, Mattia, Morgan, Clare, Hennessy, Bryan T., Eustace, Alex J., Solca, Flavio, O’Donovan, Norma, and Crown, John

Subjects
110203 Respiratory Diseases, FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, Additional_File_1___Cell_line_authentication for Combined targeting EGFR and SRC as a potential novel therapeutic approach for the treatment of triple negative breast cancer by Alexandra Canonici, Alacoque L. Browne, Mohamed F. K. Ibrahim, Kevin P. Fanning, Sandra Roche, Neil T. Conlon, Fiona O’Neill, Justine Meiller, Mattia Cremona, Clare Morgan, Bryan T. Hennessy, Alex J. Eustace, Flavio Solca, Norma O’Donovan and John Crown in Therapeutic Advances in Medical Oncology

Published
2020
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20. El desarrollo de la motricidad fina mediante la Educación Plástica en un aula de Educación Especial

Author

Latorre roche, Sandra Vanessa and Enfedaque Sancho, María

Abstract

El arte y la educación plástica fomenta en el alumnado, especialmente en niños con necesidades educativas especiales, el uso de la creatividad, la mejora de la motricidad fina y el desarrollo integral de la persona. La manera de conseguirlo es, dejando como docente, una libre expresión del alumnado donde no haya una sola respuesta correcta ante la tarea y adaptando las actividades al nivel cognitivo y personal de cada alumno de manera individualizada. Nuestra labor como maestros educar y formar personas competentes capaces de dar distintas soluciones a un mismo problema.

Published
2020

21. Neratinib plus dasatinib is highly synergistic in HER2-positive breast cancer in vitroand in vivo

Author

Conlon, Neil T, Roche, Sandra, Mahdi, Amira F, Browne, Alacoque, Breen, Laura, Gaubatz, Johanna, Meiller, Justine, O'Neill, Fiona, O'Driscoll, Lorraine, Cremona, Mattia, Hennessy, Bryan T, Eli, Lisa D, Crown, John, and Collins, Denis M

Abstract

•This study provides a comprehensive pre-clinical assessment of neratinib and dasatinib in models of HER2-positive breast cancer.•The combination of neratinib plus dasatinib was highly synergistic across breast cancer subtypes, with particular sensitivity observed in innately trastuzumab-resistant and acquired neratinib-resistant HER2-positive breast cancer models.•Neratinib plus dasatinib prevented the emergence of neratinib resistance in vitroand in vivo.•Neratinib plus dasatinib was well tolerated and showed a prolonged anti-tumour growth effect in vivo.

Published
2024
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22. Establishment and Characterisation by Expression Microarray of Patient-Derived Xenograft Panel of Human Pancreatic Adenocarcinoma Patients

Author

Roche, Sandra, primary, O’Neill, Fiona, additional, Murphy, Jean, additional, Swan, Niall, additional, Meiller, Justine, additional, Conlon, Neil T., additional, Geoghegan, Justin, additional, Conlon, Kevin, additional, McDermott, Ray, additional, Rahman, Rozana, additional, Toomey, Sinead, additional, Straubinger, Ninfa L., additional, Straubinger, Robert M., additional, O’Connor, Robert, additional, McVey, Gerard, additional, Moriarty, Michael, additional, and Clynes, Martin, additional

Published
2020
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23. Combined targeting EGFR and SRC as a potential novel therapeutic approach for the treatment of triple negative breast cancer

Author

Canonici, Alexandra, primary, Browne, Alacoque L., additional, Ibrahim, Mohamed F. K., additional, Fanning, Kevin P., additional, Roche, Sandra, additional, Conlon, Neil T., additional, O’Neill, Fiona, additional, Meiller, Justine, additional, Cremona, Mattia, additional, Morgan, Clare, additional, Hennessy, Bryan T., additional, Eustace, Alex J., additional, Solca, Flavio, additional, O’Donovan, Norma, additional, and Crown, John, additional

Published
2020
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25. Dasatinib Treatment Increases Sensitivity to c-Met Inhibition in Triple-Negative Breast Cancer Cells

Author

Gaule, Patricia, primary, Mukherjee, Nupur, additional, Corkery, Brendan, additional, Eustace, Alex, additional, Gately, Kathy, additional, Roche, Sandra, additional, O’Connor, Robert, additional, O’Byrne, Kenneth, additional, Walsh, Naomi, additional, Duffy, Michael, additional, Crown, John, additional, and O’Donovan, Norma, additional

Published
2019
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26. Polypyridyl‐Based Copper Phenanthrene Complexes: Combining Stability with Enhanced DNA Recognition.

Author

Fantoni, Nicoló Zuin, Molphy, Zara, O'Carroll, Sinéad, Menounou, Georgia, Mitrikas, George, Krokidis, Marios G., Chatgilialoglu, Chryssostomos, Colleran, John, Banasiak, Anna, Clynes, Martin, Roche, Sandra, Kelly, Suainibhe, McKee, Vickie, and Kellett, Andrew

Subjects
PHENANTHRENE, COPPER compounds, DNA damage, X-ray crystallography, HYDROXYL group, BINDING constant, DNA
Abstract

We report a series of copper(II) artificial metallo‐nucleases (AMNs) and demonstrate their DNA damaging properties and in‐vitro cytotoxicity against human‐derived pancreatic cancer cells. The compounds combine a tris‐chelating polypyridyl ligand, di‐(2‐pycolyl)amine (DPA), and a DNA intercalating phenanthrene unit. Their general formula is Cu‐DPA‐N,N' (where N,N'=1,10‐phenanthroline (Phen), dipyridoquinoxaline (DPQ) or dipyridophenazine (DPPZ)). Characterisation was achieved by X‐ray crystallography and continuous‐wave EPR (cw‐EPR), hyperfine sublevel correlation (HYSCORE) and Davies electron‐nuclear double resonance (ENDOR) spectroscopies. The presence of the DPA ligand enhances solution stability and facilitates enhanced DNA recognition with apparent binding constants (Kapp) rising from 105 to 107 m−1 with increasing extent of planar phenanthrene. Cu‐DPA‐DPPZ, the complex with greatest DNA binding and intercalation effects, recognises the minor groove of guanine–cytosine (G‐C) rich sequences. Oxidative DNA damage also occurs in the minor groove and can be inhibited by superoxide and hydroxyl radical trapping agents. The complexes, particularly Cu‐DPA‐DPPZ, display promising anticancer activity against human pancreatic tumour cells with in‐vitro results surpassing the clinical platinum(II) drug oxaliplatin. [ABSTRACT FROM AUTHOR]

Published
2021
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27. A Comparative Quantitative LC-MS/MS Profiling Analysis of Human Pancreatic Adenocarcinoma, Adjacent-Normal Tissue, and Patient-Derived Tumour Xenografts

Author

Coleman, Orla, primary, Henry, Michael, additional, O'Neill, Fiona, additional, Roche, Sandra, additional, Swan, Niall, additional, Boyle, Lorraine, additional, Murphy, Jean, additional, Meiller, Justine, additional, Conlon, Neil, additional, Geoghegan, Justin, additional, Conlon, Kevin, additional, Lynch, Vincent, additional, Straubinger, Ninfa, additional, Straubinger, Robert, additional, McVey, Gerard, additional, Moriarty, Michael, additional, Meleady, Paula, additional, and Clynes, Martin, additional

Published
2018
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31. Cover Feature: Polypyridyl‐Based Copper Phenanthrene Complexes: Combining Stability with Enhanced DNA Recognition (Chem. Eur. J. 3/2021).

Author

Fantoni, Nicoló Zuin, Molphy, Zara, O'Carroll, Sinéad, Menounou, Georgia, Mitrikas, George, Krokidis, Marios G., Chatgilialoglu, Chryssostomos, Colleran, John, Banasiak, Anna, Clynes, Martin, Roche, Sandra, Kelly, Suainibhe, McKee, Vickie, and Kellett, Andrew

Subjects
COPPER compounds, DNA, DNA repair, ELECTRON paramagnetic resonance spectroscopy
Abstract

Cover Feature: Polypyridyl-Based Copper Phenanthrene Complexes: Combining Stability with Enhanced DNA Recognition (Chem. Eur. J. 3/2021) Keywords: copper; DNA damage; DNA repair; electrochemistry; EPR spectroscopy EN copper DNA damage DNA repair electrochemistry EPR spectroscopy 828 828 1 01/18/21 20210113 NES 210113 B A new class of DNA intercalating metallodrug is reported b . Copper, DNA damage, DNA repair, electrochemistry, EPR spectroscopy. [Extracted from the article]

Published
2021
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