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10. Insulin pump therapy in type 1 diabetes is associated with lower indices of Non-Alcoholic Fatty Liver in non-obese women but not men

Author

Pepa, Giuseppe Della, primary, Lupoli, Roberta, additional, Masulli, Maria, additional, Boccia, Rosalia, additional, De Angelis, Raffaele, additional, Gianfrancesco, Salvatore, additional, Rainone, Carmen, additional, Rivellese, Angela Albarosa, additional, Annuzzi, Giovanni, additional, and Bozzetto, Lutgarda, additional

Published
2023
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12. Effects on the incidence of cardiovascular events of the addition of pioglitazone versus sulfonylureas in patients with type 2 diabetes inadequately controlled with metformin (TOSCA.IT): a randomised, multicentre trial

Author

Vaccaro, Olga, Masulli, Maria, Nicolucci, Antonio, Maggioni, Aldo Pietro, Sesti, Giorgio, Mocarelli, Paolo, Lucisano, Giuseppe, Sacco, Michele, Signorini, Stefano, Cappellini, Fabrizio, Riccardi, Gabriele, Boemi, Massimo, D'Angelo, Federica, Giansanti, Roberto, Tanase, Laura, Lanari, Luigi, Testa, Ivano, Ricci, Lucia, Pancani, Francesca, Ranchelli, Anna, Vagheggi, Paolo, Scatona, Alessia, Fontana, Lucia, Giorgino, Francesco, Laviola, Luigi, Tarantino, Lucia, Ippolito, Claudia, Gigantelli, Vittoria, Manicone, Mariangela, Conte, Eleonora, Trevisan, Roberto, Scaranna, Cristiana, Rota, Rossella, Corsi, Anna, Dodesini, Alessandro R., Reggiani, Giulio Marchesini, Montesi, Luca, Mazzella, Natalia, Forlani, Gabriele, Caselli, Chiara, Di Luzio, Raffaella, Mazzotti, Arianna, Aiello, Antimo, Barrea, Angelina, Musto, Antonio, D'Amico, Fiorentina, Squatrito, Sebastiano, Sinagra, Tiziana, Longhitano, Sara, Trowpea, Vanessa, Sparti, Maria, Italia, Salvatore, Lisi, Enrico, Grasso, Giuseppe, Pezzino, Vincenzo, Insalaco, Federica, Gnasso, Agostino, Carallo, Claudio, Scicchitano, Caterina, De Franceschi, Maria Serena, Santini, Costanza, Calbucci, Giovanni, Ripani, Raffaella, Corsi, Laura, Cuneo, Giacomo, Corsi, Simona, Giorda, Carlo B., Romeo, Francesco, Lesina, Annalisa, Comoglio, Marco, Bonetto, Caterina, Robusto, Anna, Nada, Elisa, Asprino, Vincenzo, Cetraro, Rosa, Impieri, Michelina, Lucchese, Giuseppe, Donnarumma, Giovanna, Tizio, Biagio, Clemente, Gennaro, Lenza, Lazzaro, Paraggio, Pia, Tomasi, Franco, Zamboni, Chiara, Dozio, Nicoletta, Scalambra, Egle, Mannucci, Edoardo, Lamanna, Caterina, Cignarelli, Mauro, Macchia, Olga La, Fariello, Stefania, Sorrentino, Maria Rosaria, Franzetti, Ivano, Radin, Raffaella, Cordera, Renzo, Annunziata, Francesca, Bonabello, Laura Affinito, Durante, Arianna, Dolcino, Mara, Gallo, Fiorenza, Mazzucchelli, Chiara, Aleo, Anna, Melga, Pierluigi, Briatore, Lucia, Maggi, Davide, Storace, Daniela, Cecoli, Francesca, Antenucci, Daniela, D'Ugo, Ercole, Pupillo, Mario, Baldassarre, Maria Pompea Antonia, Salvati, Filippo, Minnucci, Anita, De Luca, Angelo, Zugaro, Antonella, Santarelli, Livia, Bosco, Angela, Petrella, Vittorio, La Verghetta, Grazia Giovanna, Iannarelli, Rossella, De Gregorio, Antonella, D'Andrea, Settimio, Giuliani, Anna Elisa, Polidoro, w Lorella, Sperandio, Alessandra, Sciarretta, Filomena, Pezzella, Alfonso, Buzzetti, Raffaella, Carlone, Angela, Potenziani, Stella, Venditti, Chiara, Foffi, Chiara, Carbone, Salvatore, Cipolloni, Laura, Moretti, Chiara, Leto, Gaetano, Serra, Rosalia, Petrachi, Francesca, Romano, Isabella, Di Cianni, Graziano, Lacaria, Emilia, Russo, Laura, Goretti, Chiara, Sannino, Claudia, Gregori, Giovanna, Dolci, Maria, Bruselli, Laura, Mori, Mary L., Baccetti, Fabio, Del Freo, Maria, Di Benedetto, Antonino, Cucinotta, Domenico, Giunta, Loretta, Ruffo, Maria Concetta, Cannizzaro, Desiree, Pintaudi, Basilio, Perrone, Giovanni, Pata, Pietro, Ragonese, Francesco, Lettina, Gabriele, Mancuso, Teresa, Coppolino, Aldo, Piatti, Pier Marco, Monti, Lucilla, Stuccillo, Michela, Lucotti, Pietro, Setola, Manuela, Crippa, Giulia Valentina, Loi, Cinzia, Oldani, Matteo, Bottalico, Maria Luisa, Pellegata, Beatrice, Bonomo, Matteo, Menicatti, Laura Silvia Maria, Resi, Veronica, Bertuzzi, Federico, Disoteo, Eugenia Olga, Pizzi, Gianluigi, Rivellese, Angela Albarosa, Annuzzi, Giovanni, Capaldo, Brunella, Nappo, Rossella, Auciello, Stefania Michela, Turco, Anna Amelia, Costagliola, Lucia, Iovine, Ciro, Corte, Giuseppina Della, Vallefuoco, Pasquale, Nappi, Francesca, Vitale, Marilena, Cocozza, Sara, Ciano, Ornella, Massimino, Elena, Garofalo, Nadia, Avogaro, Angelo, Vedovato, Monica, Guarneri, Gabriella, Lapolla, Annunziata, Fedele, Domenico, Sartore, Giovanni, Chilelli, Nino Cristiano, Burlina, Silvia, Bonsembiante, Barbara, Giordano, Carla, Galluzzo, Aldo, Torregrossa, Vittoria, Dall'Aglio, Elisabetta, Mancastroppa, Giovanni, Arsenio, Leone, Cioni, Federico, Caronna, Silvana, Papi, Matteo, Babini, Massimiliano, Perriello, Gabriele, Santeusanio, Fausto, Calagreti, Gioia, Timi, Alessia, Tantucci, Alice, Marino, Cecilia, Consoli, Agostino, Ginestra, Federica, Di Biagio, Rosamaria, Taraborelli, Merilda, Del Prato, Stefano, Miccoli, Roberto, Bianchi, Cristina, Garofolo, Monia, Politi, Konstantina Savina, Penno, Giuseppe, Zavaroni, Donatella, Livraga, Stefania, Calzoni, Fabio, Mancastroppa, Giovanni Luigi Francesco, Anichini, Roberto, Corsini, Elisa, Tedeschi, Anna, Gaglianò, Maria Sole, Ippolito, Giulio, Salutini, Elisabetta, Citro, Giuseppe, Cervellino, Francesco, Natale, Maria, Salvatore, Vita, Zampino, Armando, Sinisi, Rosa, Calabrese, Maria, Arcangeli, Adolfo, Zogheri, Alessia, Guizzotti, Sandra, Longo, Rossella, Di Bartolo, Paolo, Pellicano, Francesca, Scolozzi, Patrizia, Termine, Simona, Luberto, Alessandra, Ballardini, Giorgio, Babini, Anna Carla, Trojani, Cristina, Mazzuca, Paolo, Bruglia, Matteo, Ciamei, Monica, Genghini, Silvia, Zannoni, Chiara, Pugliese, Giuseppe, Vitale, Martina, Rangel, Graziela, Salvi, Laura, Zappaterreno, Alessandra, Cordone, Samantha, Simonelli, Paola, Meggiorini, Marilla, Frasheri, Aurora, Di Pippo, Clelia, Maglio, Cristina, Mazzitelli, Giulia, Lauro, Davide, Rinaldi, Maria Elena, Galli, Angelica, Romano, Maria, D'Angelo, Paola, Leotta, Sergio, Suraci, Concetta, De Cosmo, Salvatore, Bacci, Simonetta, Palena, Antonio Pio, Genovese, Stefano, Mancino, Monica, Rondinelli, Maurizio, Capone, Filippo, Calabretto, Elisabetta, Bulgheroni, Monica, Bucciarelli, Loredana, Dotta, Francesco, Ceccarelli, Elena, Fondelli, Cecilia, Santacroce, Clorinda, Guarino, Elisa, Nigi, Laura, Lalli, Carlo, Di Vizia, Giovanni, Scarponi, Maura, Montani, Valeria, Di Bernardino, Paolo, Romagni, Paola, Dolcetti, Katia, Cannarsa, Emanuela, Forte, Elisa, Tamburo, Lucilla, Fornengo, Paolo, Perin, Paolo Cavallo, Prinzis, Tania, Gruden, Gabriella, Bruno, Graziella, Zucco, Chiara, Perotta, Massimo, Marena, Saverio, Monsignore, Simona, Panero, Francesco, Ponzi, Fulvia, Bossi, Antonio Carlo, Carpinteri, Rita, Casagrande, Maria Linda, Coletti, Maria Francesca, Balini, Annalisa, Filopanti, Marcello, Madaschi, Sara, Pulcina, Anna, Grimaldi, Franco, Tonutti, Laura, Venturini, Giorgio, Agus, Sandra, Pagnutti, Stefania, Guidotti, Francesca, Cavarape, Alessandro, Bonora, Enzo, Cigolini, Massimo, Pichiri, Isabella, Brangani, Corinna, Fainelli, Giulia, Tomasetto, Elena, Zoppini, Giacomo, Galletti, Anna, Perrone, Dominica, Capra, Claudio, Bianchini, Francesca, Ceseri, Martina, Di Nardo, Barbara, Sasso, Elisa, Bartolomei, Barbara, Suliman, Irina, Fabbri, Gianna, Romano, Geremia, Maturo, Nicola, Nunziata, Giuseppe, Capobianco, Giuseppe, De Simone, Giuseppina, Villa, Valeria, Rota, Giuseppe, Pentangelo, Carmine, Carbonara, Ornella, Caiazzo, Gennaro, Cutolo, Michele, Sorrentino, Tommasina, Mastrilli, Valeria, Amelia, Umberto, Masi, Stefano, Corigliano, Gerardo, Gaeta, Iole, Armentano, Vincenzo, Calatola, Pasqualino, Capuano, Gelsomina, Angiulli, Bruno, Auletta, Pasquale, Petraroli, Ettore, Iodice, Cinzia E., Agrusta, Mariano, Maggioni, Aldo P, Rivellese, Angela A, Giorda, Carlo B, La Macchia, Olga, Bossi, Antonio C, and di Bartolo, Paolo

Published
2017
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14. Triticum vulgare Extract and Polyhexanide (Fitostimoline® Hydrogel/Fitostimoline® Plus Gauze) versus Saline Gauze Dressing in Patients with Diabetic Foot Ulcers: Results of a Randomized Controlled Trial

Author

Della Pepa, Giuseppe, primary, Lombardi, Gianluca, additional, Gianfrancesco, Salvatore, additional, Piccolo, Roberto, additional, Chirico, Giovanni, additional, Pellegrino, Micaela, additional, Santella, Luigi, additional, Tecce, Nicola, additional, Volpicelli, Anastasia, additional, Sollo, Elena, additional, Bozzetto, Lutgarda, additional, Masulli, Maria, additional, Riccardi, Gabriele, additional, Rivellese, Angela Albarosa, additional, and Saldalamacchia, Gennaro, additional

Published
2023
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17. Risk of Sarcopenia and Associated Factors in Older Adults with Type 2 Diabetes: An Exploratory Cross-Sectional Study.

Author

Massimino, Elena, Izzo, Anna, Castaldo, Carmen, Ferretti, Erica, Rivellese, Angela Albarosa, and Della Pepa, Giuseppe

Subjects
RESEARCH, MEDITERRANEAN diet, CONFIDENCE intervals, CROSS-sectional method, ANTHROPOMETRY, SARCOPENIA, MANN Whitney U Test, FISHER exact test, TYPE 2 diabetes, RISK assessment, COMPARATIVE studies, PHYSICAL activity, QUESTIONNAIRES, MALNUTRITION, DESCRIPTIVE statistics, RESEARCH funding, DATA analysis software, OLD age
Abstract

Background: Evidence on the risk of sarcopenia and associated factors in older adults with type 2 diabetes (T2D) is lacking. We evaluate (1) the proportion of patients at risk of sarcopenia in older adults with T2D; and (2) the factors associated with the risk of sarcopenia. Methods: We conducted a cross-sectional study on T2D patients over 65 years referred to our outpatient clinic and who carried out the yearly complication assessment visit. Eligible patients were administered questionnaires during phone interviews for the risk evaluation of sarcopenia (SARC-F), the risk evaluation of malnutrition (Mini Nutritional Assessment Short Form (MNA®-SF)), the adherence to the Mediterranean diet (MEDI-quest), and the evaluation of physical activity (the International Physical Activity Questionnaire short form). Results: A total of 138 patients were included in the study, and 12 patients (8.7% (95% CI 4.6–14.7)) were at risk of sarcopenia. The mean SARC-F score was significantly higher in women compared with men (2.1 ± 1.8 vs. 0.9 ± 1.4, respectively; p < 0.001). The majority of patients identified at risk of sarcopenia compared with those not at risk were women (75% vs. 30%, respectively; p = 0.003), had a higher proportion of neuropathy (50% vs. 19%, respectively; p = 0.027), a lower mean MNA®-SF score (11.6 ± 1.5 vs. 13.0 ± 1.4, respectively; p = 0.001), a lower mean MEDI-quest score (5.2 ± 1.5 vs. 5.9 ± 1, respectively; p = 0.037), and were more inactive (92% vs. 61%, respectively; p = 0.032). Conclusions: In a sample of older adults with T2D, the risk of sarcopenia was identified in 8.7% (95% CI: 4.6–14.7) of the sample, and the main factors associated were female gender, neuropathy, a lower MNA®-SF score, low adherence to the Mediterranean diet, and low physical activity. [ABSTRACT FROM AUTHOR]

Published
2023
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18. Evidence-based European recommendations for the dietary management of diabetes.

Author

Aas, Anne-Marie, Axelsen, Mette, Churuangsuk, Chaitong, Hermansen, Kjeld, Kendall, Cyril W. C., Kahleova, Hana, Khan, Tauseef, Lean, Michael E. J., Mann, Jim I., Pedersen, Eva, Pfeiffer, Andreas, Rahelić, Dario, Reynolds, Andrew N., Risérus, Ulf, Rivellese, Angela Albarosa, Salas-Salvadó, Jordi, Schwab, Ursula, Sievenpiper, John L., Thanopoulou, Anastasia, and Uusitupa, Emeritus Matti

Abstract

Diabetes management relies on effective evidence-based advice that informs and empowers individuals to manage their health. Alongside other cornerstones of diabetes management, dietary advice has the potential to improve glycaemic levels, reduce risk of diabetes complications and improve health-related quality of life. We have updated the 2004 recommendations for the nutritional management of diabetes to provide health professionals with evidence-based guidelines to inform discussions with patients on diabetes management, including type 2 diabetes prevention and remission. To provide this update we commissioned new systematic reviews and meta-analyses on key topics, and drew on the broader evidence available. We have strengthened and expanded on the previous recommendations to include advice relating to dietary patterns, environmental sustainability, food processing, patient support and remission of type 2 diabetes. We have used the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach to determine the certainty of evidence for each recommendation based on findings from the commissioned and identified systematic reviews. Our findings indicate that a range of foods and dietary patterns are suitable for diabetes management, with key recommendations for people with diabetes being largely similar for those for the general population. Important messages are to consume minimally processed plant foods, such as whole grains, vegetables, whole fruit, legumes, nuts, seeds and non-hydrogenated non-tropical vegetable oils, while minimising the consumption of red and processed meats, sodium, sugar-sweetened beverages and refined grains. The updated recommendations reflect the current evidence base and, if adhered to, will improve patient outcomes. [ABSTRACT FROM AUTHOR]

Published
2023
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19. Triticum vulgare Extract and Polyhexanide (Fitostimoline ® Hydrogel/Fitostimoline ® Plus Gauze) versus Saline Gauze Dressing in Patients with Diabetic Foot Ulcers: Results of a Randomized Controlled Trial.

Author

Della Pepa, Giuseppe, Lombardi, Gianluca, Gianfrancesco, Salvatore, Piccolo, Roberto, Chirico, Giovanni, Pellegrino, Micaela, Santella, Luigi, Tecce, Nicola, Volpicelli, Anastasia, Sollo, Elena, Bozzetto, Lutgarda, Masulli, Maria, Riccardi, Gabriele, Rivellese, Angela Albarosa, and Saldalamacchia, Gennaro

Subjects
DIABETIC foot, WHEAT, COCAINE-induced disorders, RANDOMIZED controlled trials, PEOPLE with diabetes, HYDROGELS
Abstract

Background: The use of dressings is an essential component of the standard of care for diabetic foot ulcers (DFUs); however, despite the wide variety of dressings available, there is a lack of evidence from head-to-head randomized controlled trials. We evaluated the efficacy and safety of Triticum vulgare extract and polyhexanide (Fitostimoline® hydrogel/Fitostimoline® Plus gauze) versus saline gauze dressings in patients with DFUs. Methods: This study involved a monocentric, two-arm, open-label, controlled trial in patients with DFUs (Grades I or II, Stage A or C, based on the Texas classification) randomized to 12 weeks of dressing with Fitostimoline® hydrogel/Fitostimoline® Plus gauze or saline gauze. The number of patients with complete healing, the reduction in DFU size, and the presence of local signs and symptoms of the wound and perilesional skin were evaluated every two weeks and at the end of treatment. Results: A total of 40 adult patients were recruited (20 patients in each treatment group). The proportion of patients with complete healing was similar between the two groups (61% vs. 74%, p = 0.495, Fitostimoline® hydrogel/Fitostimoline® Plus gauze vs. saline gauze, respectively), without significant differences, as well as the reduction in DFU size. A significant improvement in local signs and symptoms of the wound and signs of perilesional skin in the Fitostimoline® hydrogel/Fitostimoline® Plus gauze compared with the saline gauze group was observed. Conclusions: In a clinical setting, the use of Fitostimoline® hydrogel/Fitostimoline® Plus gauze dressing in patients with DFUs significantly improves signs and symptoms of the wound and signs of perilesional skin compared with saline gauze dressing with a similar efficacy in terms of wound healing. [ABSTRACT FROM AUTHOR]

Published
2023
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20. Reduction of De Novo Lipogenesis Mediates Beneficial Effects of Isoenergetic Diets on Fatty Liver: Mechanistic Insights from the MEDEA Randomized Clinical Trial

Author

Costabile, Giuseppina, primary, Della Pepa, Giuseppe, additional, Salamone, Dominic, additional, Luongo, Delia, additional, Naviglio, Daniele, additional, Brancato, Valentina, additional, Cavaliere, Carlo, additional, Salvatore, Marco, additional, Cipriano, Paola, additional, Vitale, Marilena, additional, Corrado, Alessandra, additional, Rivellese, Angela Albarosa, additional, Annuzzi, Giovanni, additional, and Bozzetto, Lutgarda, additional

Published
2022
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22. Evaluation of a Whole-Liver Dixon-Based MRI Approach for Quantification of Liver Fat in Patients with Type 2 Diabetes Treated with Two Isocaloric Different Diets

Author

Brancato, Valentina, primary, Della Pepa, Giuseppe, additional, Bozzetto, Lutgarda, additional, Vitale, Marilena, additional, Annuzzi, Giovanni, additional, Basso, Luca, additional, Cavaliere, Carlo, additional, Salvatore, Marco, additional, Rivellese, Angela Albarosa, additional, and Monti, Serena, additional

Published
2022
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24. Roles and competencies in the nutritional domain for the management of the metabolic diseases and in the hospital setting: A position paper of the Italian College of Academic Nutritionists, MED-49 (ICAN-49)

Author

Pujia, Arturo, primary, Montalcini, Tiziana, additional, Donini, Lorenzo M., additional, Frittitta, Lucia, additional, Galvano, Fabio, additional, Natali, Andrea, additional, Pironi, Loris, additional, Porrini, Marisa, additional, Riso, Patrizia, additional, Rivellese, Angela Albarosa, additional, Russo, Diego, additional, Scapagnini, Giovanni, additional, Serafini, Mauro, additional, Tagliabue, Anna, additional, and De Lorenzo, Antonino, additional

Published
2021
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26. An Oily Fish Diet Improves Subclinical Inflammation in People at High Cardiovascular Risk: A Randomized Controlled Study

Author

Costabile, Giuseppina, primary, Della Pepa, Giuseppe Della, additional, Vetrani, Claudia, additional, Vitaglione, Paola, additional, Griffo, Ettore, additional, Giacco, Rosalba, additional, Vitale, Marilena, additional, Salamone, Dominic, additional, Rivellese, Angela Albarosa, additional, Annuzzi, Giovanni, additional, and Bozzetto, Lutgarda, additional

Published
2021
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27. Dietary influence on adiponectin in patients with type 2 diabetes

Author

Bozzetto, Lutgarda, primary, Polito, Rita, additional, Nigro, Ersilia, additional, Prinster, Anna, additional, Della Pepa, Giuseppe, additional, Costabile, Giuseppina, additional, Vetrani, Claudia, additional, Vitale, Marilena, additional, Daniele, Aurora, additional, Rivellese, Angela Albarosa, additional, and Annuzzi, Giovanni, additional

Published
2021
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28. Acute and chronic improvement in postprandial glucose metabolism by a diet resembling the traditional Mediterranean dietary pattern: Can SCFAs play a role?

Author

Vitale, Marilena, primary, Giacco, Rosalba, additional, Laiola, Manolo, additional, Della Pepa, Giuseppe, additional, Luongo, Delia, additional, Mangione, Anna, additional, Salamone, Dominic, additional, Vitaglione, Paola, additional, Ercolini, Danilo, additional, and Rivellese, Angela Albarosa, additional

Published
2021
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29. The combination of UCP3–55CT and PPARγ2Pro12Ala polymorphisms affects BMI and substrate oxidation in two diabetic populations

Author

LAPICE, EMANUELA, COCOZZA, SARA, PINELLI, MICHELE, GIACCO, ANGELA, RIVELLESE, ANGELA ALBAROSA, RICCARDI, GABRIELE, VACCARO, OLGA, Monticelli, A., Massimino, E., Cocozza, S., Riccardi, G., Vaccaro, O., Lapice, Emanuela, Monticelli, A., Cocozza, Sara, Pinelli, Michele, Massimino, E., Giacco, Angela, Rivellese, ANGELA ALBAROSA, Riccardi, Gabriele, Vaccaro, Olga, Cocozza, S., Riccardi, G., and Vaccaro, O.

Subjects
Male, 0301 basic medicine, Cross-sectional study, Endocrinology, Diabetes and Metabolism, Medicine (miscellaneous), Type 2 diabetes, Weight Gain, Type 2 diabete, Body Mass Index, 0302 clinical medicine, Gene Frequency, Genotype, Nutrition and Dietetic, Uncoupling Protein 3, Aged, 80 and over, Genetics, education.field_of_study, Nutrition and Dietetics, Homozygote, Middle Aged, Phenotype, Female, medicine.symptom, Cardiology and Cardiovascular Medicine, Oxidation-Reduction, Adult, Heterozygote, medicine.medical_specialty, Population, 030209 endocrinology & metabolism, Biology, BMI, 03 medical and health sciences, Internal medicine, Dietary Carbohydrates, medicine, Humans, Genetic Predisposition to Disease, Obesity, Polymorphism, education, Allele frequency, Genetic Association Studies, Aged, Polymorphism, Genetic, medicine.disease, Dietary Fats, PPAR gamma, Cross-Sectional Studies, 030104 developmental biology, Endocrinology, Diabetes Mellitus, Type 2, Energy Metabolism, Body mass index, Weight gain
Abstract

BACKGROUND AND AIM: To evaluate the combined contribution of UCP3-55CT and PPAR?2 Pro12Ala polymorphisms as correlates of BMI, energy expenditure (REE) and substrate oxidation in people with type 2 diabetes. METHODS AND RESULTS: Two independent population with type 2 diabetes were studied: population A, n = 272; population B, n = 269. Based on both UCP3 and PPAR?2 genotypes three groups were created. Carriers of the PPAR?2 Pro12Ala in combination with the CC genotype of UCP3 (ProAla/CC, group 1); carriers of only one of these genotypes (either CC/ProPro or CT-TT/ProAla, group 2); people with neither variants (CT-TT/ProPro, group 3). In both populations BMI (kg/m(2)) was highest in group 1, intermediate in group 2 and lowest in group 3, independent of energy intake (i.e 35.3 ± 6.7 vs 33.4 ± 5.4 vs 31.8 ± 3, p < 0.02, population A; 32.4 ± 4.2 vs 31.7 ± 3.8 vs 30.1 ± 2.7; p < 0.03, population B). People with the ProAla/CC genotype (group 1) showed similar REE, but lower lipid oxidation (10.9 vs 13.9 g/kg fat free mass/day; p = 0.04) and higher carbohydrate oxidation (23.6 vs 15.6 g/kg fat free mass/day; p = 0.02) than carriers of other genotypes. CONCLUSIONS: The combination of UCP3-55 CC and PPAR?2 Pro12Ala genotypes is associated with significantly higher BMI than other PPAR?2-UCP3 genotype combinations, partly due to a reduced ability in lipids oxidation. The relative importance of these mechanism(s) may be different in non diabetic people. Copyright © 2016 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.

Published
2016

30. A Call to Action: Now Is the Time to Screen Elderly and Treat Osteosarcopenia, a Position Paper of the Italian College of Academic Nutritionists MED/49 (ICAN-49)

Author

Montalcini, Tiziana, primary, Pujia, Arturo, additional, Donini, Lorenzo M., additional, Frittitta, Lucia, additional, Galvano, Fabio, additional, Natali, Andrea, additional, Pironi, Loris, additional, Porrini, Marisa, additional, Riso, Patrizia, additional, Rivellese, Angela Albarosa, additional, Russo, Diego, additional, Scapagnini, Giovanni, additional, Serafini, Mauro, additional, Tagliabue, Anna, additional, and De Lorenzo, Antonino, additional

Published
2020
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33. Effects of a multifactorial ecosustainable isocaloric diet on liver fat in patients with type 2 diabetes: randomized clinical trial

Author

Della Pepa, Giuseppe, primary, Vetrani, Claudia, additional, Brancato, Valentina, additional, Vitale, Marilena, additional, Monti, Serena, additional, Annuzzi, Giovanni, additional, Lombardi, Gianluca, additional, Izzo, Anna, additional, Tommasone, Marianna, additional, Cipriano, Paola, additional, Clemente, Gennaro, additional, Mirabelli, Peppino, additional, Mancini, Marcello, additional, Salvatore, Marco, additional, Riccardi, Gabriele, additional, Rivellese, Angela Albarosa, additional, and Bozzetto, Lutgarda, additional

Published
2020
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34. Pasta Consumption and Connected Dietary Habits: Associations with Glucose Control, Adiposity Measures, and Cardiovascular Risk Factors in People with Type 2 Diabetes—TOSCA.IT Study

Author

Vitale, Marilena, primary, Masulli, Maria, additional, Rivellese, Angela Albarosa, additional, Bonora, Enzo, additional, Babini, Anna Carla, additional, Sartore, Giovanni, additional, Corsi, Laura, additional, Buzzetti, Raffaella, additional, Citro, Giuseppe, additional, Baldassarre, Maria Pompea Antonia, additional, Bossi, Antonio Carlo, additional, Giordano, Carla, additional, Auciello, Stefania, additional, Dall’Aglio, Elisabetta, additional, Iannarelli, Rossella, additional, Tonutti, Laura, additional, Sacco, Michele, additional, Di Cianni, Graziano, additional, Clemente, Gennaro, additional, Gregori, Giovanna, additional, Grioni, Sara, additional, Krogh, Vittorio, additional, Riccardi, Gabriele, additional, and Vaccaro, Olga, additional

Published
2019
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35. Gastrointestinal effects of extra-virgin olive oil associated with lower postprandial glycemia in type 1 diabetes

Author

Bozzetto, Lutgarda, primary, Alderisio, Antonio, additional, Clemente, Gennaro, additional, Giorgini, Marisa, additional, Barone, Francesca, additional, Griffo, Ettore, additional, Costabile, Giuseppina, additional, Vetrani, Claudia, additional, Cipriano, Paola, additional, Giacco, Angela, additional, Riccardi, Gabriele, additional, Rivellese, Angela Albarosa, additional, and Annuzzi, Giovanni, additional

Published
2019
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36. Impact of a Mediterranean Dietary Pattern and Its Components on Cardiovascular Risk Factors, Glucose Control, and Body Weight in People with Type 2 Diabetes: A Real-Life Study

Author

Vitale, Marilena, Masulli, Maria, Calabrese, Ilaria, Rivellese, Angela Albarosa, Bonora, Enzo, Signorini, Stefano, Perriello, Gabriele, Squatrito, Sebastiano, Buzzetti, Raffaella, Sartore, Giovanni, Babini, Anna Carla, Gregori, Giovanna, Giordano, Carla, Clemente, Gennaro, Grioni, Sara, Dolce, Pasquale, Riccardi, Gabriele, Vaccaro, Olga, IT Study Group, Tosca., Vitale, Marilena, Masulli, Maria, Calabrese, Ilaria, Rivellese, Angela Albarosa, Bonora, Enzo, Signorini, Stefano, Perriello, Gabriele, Squatrito, Sebastiano, Buzzetti, Raffaella, Sartore, Giovanni, Babini, Anna Carla, Gregori, Giovanna, Giordano, Carla, Clemente, Gennaro, Grioni, Sara, Dolce, Pasquale, Riccardi, Gabriele, and Vaccaro, Olga

Subjects
Blood Glucose, Male, Mediterranean diet, cardiovascular risk, diabetes, glucose control, plasma lipids, relative Mediterranean diet score, Aged, Biomarkers, Blood Pressure, Cardiovascular Diseases, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Female, Glycated Hemoglobin A, Humans, Lipids, Middle Aged, Nutritive Value, Patient Compliance, Protective Factors, Recommended Dietary Allowances, Risk Factors, Body Mass Index, Diet, Healthy, Diet, Mediterranean, Feeding Behavior, Recommended Dietary Allowance, Cross-sectional study, Healthy Diet, Saturated fat, Type 2 diabetes, 030204 cardiovascular system & hematology, Mediterranean, Diabete, Settore MED/13 - Endocrinologia, chemistry.chemical_compound, 0302 clinical medicine, Cardiovascular Disease, 030212 general & internal medicine, Nutrition and Dietetics, Lipid, European Prospective Investigation into Cancer and Nutrition, lcsh:Nutrition. Foods and food supply, Type 2, Human, Cardiovascular risk, Diabetes, Glucose control, Plasma lipids, Relative mediterranean diet score, Food Science, Plasma lipid, lcsh:TX341-641, Article, 03 medical and health sciences, Environmental health, Diabetes mellitus, medicine, Diabetes Mellitus, Protective Factor, Cross-Sectional Studie, Glycated Hemoglobin, Healthy, business.industry, Risk Factor, Biomarker, medicine.disease, Diet, chemistry, Glycated hemoglobin, business, Body mass index
Abstract

This study evaluates the relation of a Mediterranean dietary pattern and its individual components with the cardiovascular risk factors profile, plasma glucose and body mass index (BMI) in people with type 2 diabetes. We studied 2568 participants at 57 diabetes clinics. Diet was assessed with the EPIC (European Prospective Investigation into Cancer and Nutrition) questionnaire, adherence to the Mediterranean diet was evaluated with the relative Mediterranean diet score (rMED). A high compared to a low score was associated with a better quality of diet and a greater adherence to the nutritional recommendations for diabetes. However, even in the group achieving a high score, only a small proportion of participants met the recommendations for fiber and saturated fat (respectively 17% and 30%). Nonetheless, a high score was associated with lower values of plasma lipids, blood pressure, glycated hemoglobin, and BMI. The relationship of the single food items components of the rMED score with the achievement of treatment targets for plasma lipids, blood pressure, glucose, and BMI were also explored. The study findings support the Mediterranean dietary model as a suitable model for type 2 diabetes and the concept that the beneficial health effects of the Mediterranean diet lie primarily in its synergy among various nutrients and foods rather than on any individual component.

Published
2018

38. Effects of a diet naturally rich in polyphenols on lipid composition of postprandial lipoproteins in high cardiometabolic risk individuals: an ancillary analysis of a randomized controlled trial

Author

Della Pepa, Giuseppe, primary, Vetrani, Claudia, additional, Vitale, Marilena, additional, Bozzetto, Lutgarda, additional, Costabile, Giuseppina, additional, Cipriano, Paola, additional, Mangione, Anna, additional, Patti, Lidia, additional, Riccardi, Gabriele, additional, Rivellese, Angela Albarosa, additional, and Annuzzi, Giovanni, additional

Published
2019
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39. Minor Contribution of Endogenous GLP-1 and GLP-2 to Postprandial Lipemia in Obese Men

Author

Matikainen N, Björnson E, Söderlund S, Borén C, Eliasson B, Pietiläinen KH, Bogl LH, Hakkarainen A, Lundbom N, RIVELLESE, ANGELA ALBAROSA, RICCARDI, GABRIELE, Després JP, Alméras N, Holst JJ, Deacon CF, Borén J, Taskinen MR, Matikainen, N, Björnson, E, Söderlund, S, Borén, C, Eliasson, B, Pietiläinen, Kh, Bogl, Lh, Hakkarainen, A, Lundbom, N, Rivellese, ANGELA ALBAROSA, Riccardi, Gabriele, Després, Jp, Alméras, N, Holst, Jj, Deacon, Cf, Borén, J, and Taskinen, Mr

Subjects
postprandial lipemia, GLP-1, gastrointestinal hormones, postprandial glucose response
Abstract

CONTEXT: Glucose and lipids stimulate the gut-hormones glucagon-like peptide (GLP)-1, GLP-2 and glucose-dependent insulinotropic polypeptide (GIP) but the effect of these on human postprandial lipid metabolism is not fully clarified. OBJECTIVE: To explore the responses of GLP-1, GLP-2 and GIP after a fat-rich meal compared to the same responses after an oral glucose tolerance test (OGTT) and to investigate possible relationships between incretin response and triglyceride-rich lipoprotein (TRL) response to a fat-rich meal. DESIGN: Glucose, insulin, GLP-1, GLP-2 and GIP were measured after an OGTT and after a fat-rich meal in 65 healthy obese (BMI 26.5-40.2 kg/m(2)) male subjects. Triglycerides (TG), apoB48 and apoB100 in TG-rich lipoproteins (chylomicrons, VLDL1 and VLDL2) were measured after the fat-rich meal. MAIN OUTCOME MEASURES: Postprandial responses (area under the curve, AUC) for glucose, insulin, GLP-1, GLP-2, GIP in plasma, and TG, apoB48 and apoB100 in plasma and TG-rich lipoproteins. RESULTS: The GLP-1, GLP-2 and GIP responses after the fat-rich meal and after the OGTT correlated strongly (r = 0.73, p

Published
2016

40. Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial

Author

Hernandez, Adrian F, Green, Jennifer B, Janmohamed, Salim, D'Agostino, Ralph B, Granger, Christopher B, Jones, Nigel P, Leiter, Lawrence A, Rosenberg, Anne E, Sigmon, Kristina N, Somerville, Matthew C, Thorpe, Karl M, Mcmurray, John J V, Del Prato, Stefano, Mcmurray, John J. V., D'Agostino, Ralph B., Granger, Christopher B., Hernandez, Adrian F., Leiter, Lawrence A., Califf, Robert M, Holman, Rury, Demets, David, Riddle, Matthew, Goodman, Shaun, Mcguire, Darren, Alexander, Karen, Devore, Adam, Melloni, Chiara, Patel, Chetan, Kong, David, Bloomfield, Gerald, Roe, Matthew, Tricoci, Pierluigi, Harrison, Rob, Lopes, Renato, Mathews, Robin, Mehta, Rajendra, Schuyler Jones, William, Vemulapalli, Sreekanth, Povsic, Thoma, Eapen, Zubin, Dombrowski, Keith, Kolls, Brad, Jordan, Dedrick, Ambrosy, Andrew, Greene, Stephen, Mandawat, Aditya, Shavadia, Jay, Cooper, Lauren, Sharma, Abhinav, Guimaraes, Patricia, Friedman, Daniel, Wilson, Matt, Endsley, Patricia, Gentry, Tracy, Collier, Jeannie, Perez, Kathleen, James, Kourtnei, Roush, Jennifer, Pope, Connie, Howell, Christina, Johnson, Megan, Bailey, Matt, Cole, Joanna, Akers, Teresa, Vandyne, Beth, Thomas, Betsy, Rich, Jenny, Bartone, Susan, Beaulieu, Gail, Brown, Kim, Chau, Tuan, Christian, Tamra, Coker, Rebecca, Greene, Deb, Haddock, Trevorlyn, Jenkins, Wendy, Haque, Ghazala, Marquess, Marsha, Pesarchick, Jean, Rethaford, Renee, Stone, Allegra, Al Kawas, Fira, Anderson, Michelle, Enns, Robert, Sinay, Isaac, Mathieu, Chantal, Yordanov, Victor, Hramiak, Irene, Haluzik, Martin, Galatius, Søren, Guerci, Bruno, Nauck, Michael, Migdalis, Ilia, Tan, Choon Beng Kathryn, Kocsis, Gyozo, Giaccari, Andrea, Lee, Moon Kyu, Muñoz, Ernesto German Cardona, Cornel, Jan, Birkeland, Kare, Pinto, Miguel, Tirador, Louie, Olesinska-Mader, Martyna, Shestakova, Marina, Distiller, Larry, Lopez-Sendon, Jose, Eliasson, Bjorn, Chiang, Chern-En, Srimahachota, Suphot, Mankovsky, Bori, Bethel, M Angelyn, Dungan, Kathleen, Kosiborod, Mikhail, Alvarisqueta, Andre, Baldovino, Jorge, Besada, Diego, Calella, Pedro, Cantero, Maria Cecilia, Castaño, Patricia, Chertkoff, Alejandro, Cuadrado, Jesu, De Loredo, Lui, Dominguez, Andrea, Español, Maria Vanesa, Finkelstein, Hernan, Frechtel, Gustavo, Fretes, Jose, Garrido Santos, Natalia, Gonzalez, Joaquin, Litvak, Marco, Loureyro, Juan, Maffei, Laura, Maldonado, Natacha, Mohr Gasparini, Diego, Orio, Silvia, Perez Manghi, Federico, Rodriguez Papini, Nelson, Sala, Jorgelina, Schygiel, Pablo, Sposetti, Georgina, Ulla, Maria, Verra, Fernando, Zabalua, Silvina, Zaidman, Cesar, Crenier, Laurent, Debroye, Corinne, Duyck, Franci, Scheen, André, Van Gaal, Luc, Vercammen, Chri, Damyanova, Velichka, Dimitrov, Stefan, Kovacheva, Snezhina, Lozanov, Lachezar, Margaritov, Viktor, Mihaylova-Shumkova, Rositsa, Nikolaeva, Antoaneta, Stoyanova, Zhasmina, Akhras, Ronald, Beaudry, Yve, Bedard, Jacque, Berlingieri, Joseph, Chehayeb, Raja, Cheung, Stephen, Conway, Jame, Cusson, Jean, Della Siega, Anthony, Dumas, Richard, Dzongowski, Peter, Ferguson, Murdo, Gaudet, Daniel, Grondin, Francoi, Gupta, Anil, Gupta, Milan, Halperin, Frank, Houle, Pierre-Alain, Jones, Michael, Kouz, Simon, Kovacs, Christopher, Landry, Daniel, Lonn, Eva, O'Mahony, William, Peterson, Sean, Reich, Denni, Rosenbloom, Alan, St-Maurice, Francoi, Tugwell, Barna, Vizel, Saul, Woo, Vincent, Brychta, Toma, Cech, Vladimir, Dvorakova, Eva, Edelsberger, Toma, Halciakova, Katarina, Krizova, Jarmila, Lastuvka, Jiri, Piperek, Martin, Prymkova, Vera, Raclavska, Lea, Silhova, Elena, Urbanek, Robin, Vrkoc, Jan, Andersen, Ulla, Brønnum-Schou, Jen, Hove, Jen, Jensen, Jan Skov, Kober, Lar, Kristiansen, Ole Peter, Lund, Per, Melchior, Thoma, Nyvad, Ole, Schou, Morten, Boye, Alain, Cadinot, Didier, Gouet, Didier, Henry, Patrick, Kessler, Laurence, Lalau, Jean-Daniel, Petit, Catherine, Thuan, Jean-Francoi, Voinot, Christel, Vouillarmet, Julien, Axthelm, Christoph, Berger, Dirk, Bieler, Tasso, Birkenfeld, Andrea, Bott, Jochen, Busch, Klau, Caca, Karel, Chevts, Julia, Donaubauer, Torsten, Erlinger, Rudolf, Funke, Klau, Grosskopf, Josef, Hagenow, Andrea, Hamann, Monika, Hartard, Manfred, Heymer, Peter, Huppertz, Wolfgang, Illies, Gabriele, Jacob, Stephan, Jung, Thoma, Kahrmann, Gerd, Kast, Petra, Kellerer, Monika, Kempe, Hans-Peter, Khariouzov, Andrei, Klausmann, Gerhard, Klein, Christiane, Kleinecke-Pohl, Uwe, Kleinertz, Klau, Koch, Thorsten, Kosch, Christine, Lorra, Babette, Luedemann, Joerg, Luttermann, Matthia, Maxeiner, Stephan, Milek, Karsten, Moelle, Andrea, Neumann, Gerhard, Nischik, Ruth, Oehrig-Pohl, Edith, Plassmann, Georg, Pohlmeier, Lar, Proepper, Felix, Regner, Stefan, Rieker, Werner, Rose, Ludger, Samer, Holger, Sauter, Joachim, Schaper, Frank, Schiffer, Clemen, Schmidt, Juergen, Scholz, Bernd-M., Schulze, Joerg, Segner, Alexander, Seufert, Jochen, Sigal, Helena, Steindorf, Joerg, Stockhausen, Juergen, Stuebler, Petra, Taeschner, Heidrun, Tews, Dietrich, Tschoepe, Diethelm, Wilhelm, Karl, Zeller-Stefan, Helga, Avramidis, Iakovo, Bousboulas, Stavro, Bristianou, Magdalini, Dimitriadis, Georgio, Elisaf, Mose, Kotsa, Kalliopi, Melidonis, Andrea, Mitrakou, Asimina, Pagkalos, Emmanouil, Papanas, Nikolao, Pappas, Angelo, Sampanis, Christo, Tentolouris, Nikolao, Tsapas, Apostolo, Tzatzagou, Glykeria, Ozaki, Risa, Hajdú, Csaba, Harcsa, Eleonóra, Konyves, Laszlo, Mucsi, Jáno, Pauker, Zsolt, Petró, Gizella, Plés, Zsolt, Revesz, Katalin, Sándor, Vangel, Vass, Viktor, Avogaro, Angelo, Boemi, Massimo, Bonadonna, Riccardo, Consoli, Agostino, De Cosmo, Salvatore, Di Bartolo, Paolo, Dotta, Francesco, Frontoni, Simona, Galetta, Marianna, Gambineri, Alessandra, Gazzaruso, Carmine, Giorgino, Francesco, Lauro, Davide, Orsi, Emanuela, Paolisso, Giuseppe, Perriello, Gabriele, Piatti, Piermarco, Pontiroli, Antonio, Ponzani, Paola, Rivellese, Angela Albarosa, Sesti, Giorgio, Tonolo, Giancarlo, Trevisan, Roberto, Ahn, Chul Woo, Baik, Sei-Hyun, Cha, Bong-Soo, Chung, Choon-Hee, Jang, Hak Chul, Kim, Chong-Jin, Kim, Hye Soon, Kim, In Joo, Lee, Eun Young, Lee, Hyoung Woo, Lee, Kwan-Woo, Moon, Keon-Woong, Namgung, June, Park, Kyong Soo, Yoo, Soon Jib, Yu, Jaemyung, Llamas, Edmundo-Alfredo Bayram, Cervantes-Escárcega, Jose-Lui, Flota-Cervera, Luis Fernando, González-González, José Gerardo, Pascoe-Gonzalez, Sara, Pelayo-Orozco, Emilia Susana, Ramirez-Diaz, Santiago-Paulino, Saldana-Mendoza, Arturo, Jerjes-Díaz, Carlos Sánchez, Torres-Colores, Jose Juan, Vidrio-Velázquez, Maricela, Villagordoa-Mesa, Juan, Beijerbacht, Hugo Peter, Groutars, Reginald G. E. J., Hoek, Boudewijn A, Hoogslag, Pieter A. M., Kooy, Adriaan, Kragten, Johannes A., Lieverse, Aloysius G., Swart, Hendrik P., Viergever, Eric P., Ahlqvist, Jørn, Cooper, John, Gulseth, Hanne, Guttormsen, Gaute, Wium, Cecilie, Arbañil, Hugo, Calderon, Jorge, Camacho, Lui, Espinoza, Augusto Dextre, Garrido, Elizabeth, Luna, Alejandro, Manrique, Helard, Revoredo, Frederick Massucco, Gonzales, Rolando Varga, Rincon, Luis Zapata, Zubiate, Carlo, Ebo, Geraldine, Morales-Palomares, Ellen, Arciszewska, Malgorzata, Banach, Marek, Bijata-Bronisz, Renata, Derezinski, Tadeusz, Gadzinski, Waldemar, Gajek, Jacek, Klodawska, Katarzyna, Krzyzagorska, Ewa, Madej, Andrzej, Miekus, Pawel, Opiela, Jaroslaw, Romanczuk, Piotr, Siegel, Anna, Skokowska, Ewa, Stankiewicz, Andrzej, Stasinska, Teresa, Trznadel-Morawska, Iwona, Witek, Robert, Aksentyev, Sergey, Bondar, Irina, Demidova, Irina, Dreval, Alexander, Ershova, Olga, Galstyan, Gagik, Garganeeva, Alla, Izmozherova, Nadezhda, Karetnikova, Victoria, Kharakhulakh, Marina, Khokhlov, Aleksandr, Kobalava, Zhanna, Koshelskaya, Olga, Kosmacheva, Elena, Kostin, Vladimir, Koziolova, Natalia, Kuzin, Anatoly, Lesnov, Victor, Lysenko, Tatyana, Markov, Valentin, Mayorov, Alexander, Moiseev, Sergey, Myasoedova, Svetlana, Petunina, Nina, Rebrov, Andrey, Ruyatkina, Ludmila, Samoylova, Julia, Sazonova, Olga, Shilkina, Natalia, Sokolova, Nadezhda, Vasilevskaya, Olga, Verbovaya, Nelli, Vishneva, Elena, Vorobyev, Sergey, Vorokhobina, Natalya, Zanozina, Olga, Zhdanova, Elena, Zykova, Tatyana, Burgess, Lesley, Coetzee, Kathleen, Dawood, Saleem, Lombard, Landman, Makotoko, Ellen, Moodley, Rajendran, Oosthuysen, Wessel, Sarvan, Mohamed, Calvo Gómez, Carlo, Cano Rodríguez, Isidoro, Castro Conde, Almudena, Cequier Fillat, Angel, Cuatrecasas Cambra, Guillem, de Álvaro Moreno, Fernando, De Teresa Parreño, Lui, Delgado Lista, Javier, Domínguez Escribano, José Ramón, Durán García, Santiago, Elvira González, Javier, Fernández Rodríguez, José María, Goday Arno, Alberto, Gomez Huelgas, Ricardo, González Juanatey, José Ramón, Hernandez Mijares, Antonio, Jiménez Díaz, Víctor Alfonso, Jodar Gimeno, Esteban, Lucas Morante, Tomá, Marazuela, Monica, Martell Claros, Nieve, Mauricio Puente, Didac, Mena Ribas, Elena, Merino Torres, Juan Francisco, Mezquita Raya, Pedro, Nubiola Calonge, Andreu, Ordoñez Sánchez, Xavier, Pascual Izuel, Jose Maria, Perea Castilla, Verónica, Pérez Pérez, Antonio, Perez Soto, Isabel, Quesada Charneco, Miguel, Quesada Simón, Angustia, Redón Mas, Josep, Rego Iraeta, Antonia, Rodriguez Alvarez, Maria, Rodríguez Rodríguez, Irene, Sabán Ruiz, José, Soto González, Alfonso, Tinahones Madueno, Francisco, Trescoli Serrano, Carlo, Ulied Armiñana, Angel, Bachus, Erasmu, Berndtsson Blom, Katarina, Eliasson, Ken, Koskinen, Pekka, Larnefeldt, Han, Lif-Tiberg, Cornelia, Linderfalk, Carina, Lund, Gustav, Lundman, Pia, Moris, Linda, Olsson, Åke, Salmonsson, Staffan, Sanmartin Berglund, Johan, Sjöberg, Folke, Söderberg, Stefan, Torstensson, Ingemar, Chen, Jung-Fu, Tien, Kai Jen, Tseng, Shih-Ting, Tu, Shih-Te, Wang, Chih-Yuan, Wang, Ji-Hung, Phrommintikul, Arintaya, Yamwong, Sukit, Jintapakorn, Woravut, Hutayanon, Pisit, Sansanayudh, Nakarin, Bazhan, Larysa, Fushtey, Ivan, Grachova, Mariya, Katerenchuk, Vitaliy, Korpachev, Vadym, Kravchun, Nonna, Larin, Oleksandr, Mykhalchyshyn, Galyna, Myshanych, Halyna, Oleksyk, Olga, Orlenko, Valeriia, Pashkovska, Nataliia, Pertseva, Nataliia, Petrosyan, Olena, Smirnov, Ivan, Vlasenko, Maryna, Zlova, Tetiana, Aye, Myint, Baksi, Arun, Balasubramani, Mathangi, Beboso, Ronnie, Blagden, Mark, Bundy, Charle, Cookson, Tobia, Copland, Allan, Emslie-Smith, Alistair, Green, Fiona, Gunstone, Anthony, Issa, Basil, Jackson-Voyzey, Ewart, Johnson, Andrew, Maclean, Malcolm, Mcknight, John, Muzulu, Solomon, O'Connell, Ian, Oyesile, Babatunde, Patterson, Catherine, Pearson, Ewan, Philip, Sam, Smith, Paul, Sukumaran, Usha, Abbas, Jalal, Aggarwala, Gaurav, Akhter, Faiq, Andersen, Jame, Anglade, Moise, Argoud, George, Ariani, Mehrdad, Ashdji, Reswan, Bakhtari, Ladan, Banerjee, Subhash, Bartlett, Andrew, Baum, Howard, Bays, Harold, Beasley, Richard, Belfort de Aguiar, Renata, Benjamin, Sabrina, Bhagwat, Ravi, Bhargava, Anuj, Bode, Bruce, Bratcher, Christina, Briskin, Toby, Brockmyre, Andrew, Broughton, Raymond, Brown, Judith, Budhraja, Madhusudan, Cannon, Kevin, Carr, Jewell, Cathcart, Harold, Cavale, Arvind, Chaykin, Loui, Cheung, Deanna, Childress, Richard, Cohen, Allan, Condit, Jonathan, Cooksey, Erin, Cornett, George Mitchell, Dauber, Ira, Davila, William, De Armas, Lui, Dean, Juliu, Detweiler, Robert, Diaz, Ernesto, Di Giovanna, Michael, Dor, Isaac, Drummond, Waymon, Eagerton, Donald, Earl, John, Eaton, Charle, Ellison, Howard, Farris, Neil, Fiel, Thoma, Firek, Anthony, First, Brian, Forgosh, Le, French, William, Gandy, Winston, Garcia, Ronald, Gill, Santosh, Gordon, Murray, Guice, Michael, Gummadi, Siva, Hackenyos, Jonathan, Hairston, Kristen, Hanson, Lenita, Harrison, Lindsay, Hartman, Israel, Heitner, John, Hejeebu, Srini, Hermany, Paul, Hernandez-Cassis, Carlo, Hidalgo, Horacio, Higgins, Alexander, Ibrahim, Hassan, Jacobs, Shahram, Johnson, David, Joshi, Parag, Kaster, Steven, Kellum, Daniel, Kim, Christopher, Kim, Ellen, Kirby, William, Knouse, Albert, Kulback, Steven, Kumar, Mariananda, Kuruvanka, Tulsida, Labroo, Ajay, Lasswell, William, Lentz, John, Lenzmeier, Thoma, Lewis, David, Li, Zhaoping, Lillestol, Michael, Little, Raymond, Lorraine, Richard, McKeown-Biagas, Cecilia, Mcneill, Robert, Mehta, Anand, Miller, Alan, Moran, Joseph, Morawski, Emily, Nadar, Venkatesh, O'Connor, Thoma, Odio, Alberto, Parker, Reginald, Patel, Rajesh, Phillips, Lawrence, Raad, George, Rahman, Aref, Raikhel, Marina, Raisinghani, Ajit, Rajan, Raj, Rasouli, Neda, Rauzi, Frank, Rohr, Kathryn, Roseman, Hal, Rovner, Sergio, Saba, Fadi, Sachson, Richard, Schabauer, Alex, Schneider, Ricky, Schuchard, Timothy, Sensenbrenner, John, Shlesinger, Yshay, Singh, Narendra, Sivalingam, Kanagaratnam, Stonesifer, Larry, Storey, Daniel, Suh, David, Tahir, Mohammed, Tan, Anjanette, Tan, Marilyn, Taylon, Alain, Thakkar, Maitreya, Tripathy, Devjit, Uwaifo, Gabriel, Vedere, Amarnath, Venugopal, Chandra, Vo, Anthony, Welch, Michelle, Welker, Jame, White, Alexander, Willis, John, Wynne, Alan, Yazdani, Shahram, Rosenberg, Anne, Price, Lauren, Sigmon, Kristina, Lokhngina, Yuliya, Xing, Weibing, Overton, Robert, Stewart, Murray, Stead, Janet, Lindsay, Alistair, Patel, Vicka, Ross, Jorge, Soffer, Joseph, Daga, Shruti, Sowell, Margaret, Patel, Prashant, Garvey, Louisa, Ackert, Jessica, Abraham, Sybil, Sabol, Mary Beth, Altobelli, Desma, Ha, Juyoung, Kulkarni, Mangesh, Somerville, Matthew, Noronha, Drusilla, Casson, Ed, Zang, Eddie, Sandhu, Chamandeep, Kumar, Rakesh, Chen, David, Taft, Lin, Patel, Rajivkumar, Ye, June, Shannon, Jennifer, Wilson, Tim, Babi, Charleen, Miller, Diane, Thorpe, Karl, Russell, Rachael, Bull, Georgina, Hereghty, Belinda, Fernandez-Salazar, Eva, Longley, Troy, Donaldson, Jill, Jarosz, Marie, Murphy, Karen, Adams, Patricia, Smith, Peter, James, Rachel, Richards, Jackie, Sedani, Sangeeta, Althouse, Denise, Watson, David, Lorimer, Jamie, Lauder, Steven, Schultheis, Ron, Womer, Terese, Wraight, Ella, Li, Wenyan, Price-Olsen, Emma, Watson, Anthony, Kelly, Aoife, Mclaughlin, Patricia, Fleming, John, Schubert, Jessica, Schleiden, Debra, Harris, Tara, Prakash, Rahul, Breneman, Jody, Deshpande, Sameer, Saswadkar, Aarti, Kumari, Aditi, Shitut, Aditi, Raorane, Amruta, Karmalkar, Anisha, Mhambrey, Ankita, Bhosale, Archana, Vaphare, Ashok, Patil, Ashwini P, Khandelwal, Chaitali, Shaik, Fayaz, Nadar, Madhumitha, Karka, Mounika, Kadgaonkar, Neha, Gupta, Nikita, Aher, Nutan, Potnis, Omkar, Naicker, Pallavi, Shinde, Rakesh, Sharma, Richa, Godse, Rupali, Solanki, Sheetal, Sahu, Shruti, Dumbre, Snehal, Kumar, Somesh, Patil, Suradnya, Mandal, Trisha, Giaccari, Andrea (ORCID:0000-0002-7462-7792), Hernandez, Adrian F, Green, Jennifer B, Janmohamed, Salim, D'Agostino, Ralph B, Granger, Christopher B, Jones, Nigel P, Leiter, Lawrence A, Rosenberg, Anne E, Sigmon, Kristina N, Somerville, Matthew C, Thorpe, Karl M, Mcmurray, John J V, Del Prato, Stefano, Mcmurray, John J. V., D'Agostino, Ralph B., Granger, Christopher B., Hernandez, Adrian F., Leiter, Lawrence A., Califf, Robert M, Holman, Rury, Demets, David, Riddle, Matthew, Goodman, Shaun, Mcguire, Darren, Alexander, Karen, Devore, Adam, Melloni, Chiara, Patel, Chetan, Kong, David, Bloomfield, Gerald, Roe, Matthew, Tricoci, Pierluigi, Harrison, Rob, Lopes, Renato, Mathews, Robin, Mehta, Rajendra, Schuyler Jones, William, Vemulapalli, Sreekanth, Povsic, Thoma, Eapen, Zubin, Dombrowski, Keith, Kolls, Brad, Jordan, Dedrick, Ambrosy, Andrew, Greene, Stephen, Mandawat, Aditya, Shavadia, Jay, Cooper, Lauren, Sharma, Abhinav, Guimaraes, Patricia, Friedman, Daniel, Wilson, Matt, Endsley, Patricia, Gentry, Tracy, Collier, Jeannie, Perez, Kathleen, James, Kourtnei, Roush, Jennifer, Pope, Connie, Howell, Christina, Johnson, Megan, Bailey, Matt, Cole, Joanna, Akers, Teresa, Vandyne, Beth, Thomas, Betsy, Rich, Jenny, Bartone, Susan, Beaulieu, Gail, Brown, Kim, Chau, Tuan, Christian, Tamra, Coker, Rebecca, Greene, Deb, Haddock, Trevorlyn, Jenkins, Wendy, Haque, Ghazala, Marquess, Marsha, Pesarchick, Jean, Rethaford, Renee, Stone, Allegra, Al Kawas, Fira, Anderson, Michelle, Enns, Robert, Sinay, Isaac, Mathieu, Chantal, Yordanov, Victor, Hramiak, Irene, Haluzik, Martin, Galatius, Søren, Guerci, Bruno, Nauck, Michael, Migdalis, Ilia, Tan, Choon Beng Kathryn, Kocsis, Gyozo, Giaccari, Andrea, Lee, Moon Kyu, Muñoz, Ernesto German Cardona, Cornel, Jan, Birkeland, Kare, Pinto, Miguel, Tirador, Louie, Olesinska-Mader, Martyna, Shestakova, Marina, Distiller, Larry, Lopez-Sendon, Jose, Eliasson, Bjorn, Chiang, Chern-En, Srimahachota, Suphot, Mankovsky, Bori, Bethel, M Angelyn, Dungan, Kathleen, Kosiborod, Mikhail, Alvarisqueta, Andre, Baldovino, Jorge, Besada, Diego, Calella, Pedro, Cantero, Maria Cecilia, Castaño, Patricia, Chertkoff, Alejandro, Cuadrado, Jesu, De Loredo, Lui, Dominguez, Andrea, Español, Maria Vanesa, Finkelstein, Hernan, Frechtel, Gustavo, Fretes, Jose, Garrido Santos, Natalia, Gonzalez, Joaquin, Litvak, Marco, Loureyro, Juan, Maffei, Laura, Maldonado, Natacha, Mohr Gasparini, Diego, Orio, Silvia, Perez Manghi, Federico, Rodriguez Papini, Nelson, Sala, Jorgelina, Schygiel, Pablo, Sposetti, Georgina, Ulla, Maria, Verra, Fernando, Zabalua, Silvina, Zaidman, Cesar, Crenier, Laurent, Debroye, Corinne, Duyck, Franci, Scheen, André, Van Gaal, Luc, Vercammen, Chri, Damyanova, Velichka, Dimitrov, Stefan, Kovacheva, Snezhina, Lozanov, Lachezar, Margaritov, Viktor, Mihaylova-Shumkova, Rositsa, Nikolaeva, Antoaneta, Stoyanova, Zhasmina, Akhras, Ronald, Beaudry, Yve, Bedard, Jacque, Berlingieri, Joseph, Chehayeb, Raja, Cheung, Stephen, Conway, Jame, Cusson, Jean, Della Siega, Anthony, Dumas, Richard, Dzongowski, Peter, Ferguson, Murdo, Gaudet, Daniel, Grondin, Francoi, Gupta, Anil, Gupta, Milan, Halperin, Frank, Houle, Pierre-Alain, Jones, Michael, Kouz, Simon, Kovacs, Christopher, Landry, Daniel, Lonn, Eva, O'Mahony, William, Peterson, Sean, Reich, Denni, Rosenbloom, Alan, St-Maurice, Francoi, Tugwell, Barna, Vizel, Saul, Woo, Vincent, Brychta, Toma, Cech, Vladimir, Dvorakova, Eva, Edelsberger, Toma, Halciakova, Katarina, Krizova, Jarmila, Lastuvka, Jiri, Piperek, Martin, Prymkova, Vera, Raclavska, Lea, Silhova, Elena, Urbanek, Robin, Vrkoc, Jan, Andersen, Ulla, Brønnum-Schou, Jen, Hove, Jen, Jensen, Jan Skov, Kober, Lar, Kristiansen, Ole Peter, Lund, Per, Melchior, Thoma, Nyvad, Ole, Schou, Morten, Boye, Alain, Cadinot, Didier, Gouet, Didier, Henry, Patrick, Kessler, Laurence, Lalau, Jean-Daniel, Petit, Catherine, Thuan, Jean-Francoi, Voinot, Christel, Vouillarmet, Julien, Axthelm, Christoph, Berger, Dirk, Bieler, Tasso, Birkenfeld, Andrea, Bott, Jochen, Busch, Klau, Caca, Karel, Chevts, Julia, Donaubauer, Torsten, Erlinger, Rudolf, Funke, Klau, Grosskopf, Josef, Hagenow, Andrea, Hamann, Monika, Hartard, Manfred, Heymer, Peter, Huppertz, Wolfgang, Illies, Gabriele, Jacob, Stephan, Jung, Thoma, Kahrmann, Gerd, Kast, Petra, Kellerer, Monika, Kempe, Hans-Peter, Khariouzov, Andrei, Klausmann, Gerhard, Klein, Christiane, Kleinecke-Pohl, Uwe, Kleinertz, Klau, Koch, Thorsten, Kosch, Christine, Lorra, Babette, Luedemann, Joerg, Luttermann, Matthia, Maxeiner, Stephan, Milek, Karsten, Moelle, Andrea, Neumann, Gerhard, Nischik, Ruth, Oehrig-Pohl, Edith, Plassmann, Georg, Pohlmeier, Lar, Proepper, Felix, Regner, Stefan, Rieker, Werner, Rose, Ludger, Samer, Holger, Sauter, Joachim, Schaper, Frank, Schiffer, Clemen, Schmidt, Juergen, Scholz, Bernd-M., Schulze, Joerg, Segner, Alexander, Seufert, Jochen, Sigal, Helena, Steindorf, Joerg, Stockhausen, Juergen, Stuebler, Petra, Taeschner, Heidrun, Tews, Dietrich, Tschoepe, Diethelm, Wilhelm, Karl, Zeller-Stefan, Helga, Avramidis, Iakovo, Bousboulas, Stavro, Bristianou, Magdalini, Dimitriadis, Georgio, Elisaf, Mose, Kotsa, Kalliopi, Melidonis, Andrea, Mitrakou, Asimina, Pagkalos, Emmanouil, Papanas, Nikolao, Pappas, Angelo, Sampanis, Christo, Tentolouris, Nikolao, Tsapas, Apostolo, Tzatzagou, Glykeria, Ozaki, Risa, Hajdú, Csaba, Harcsa, Eleonóra, Konyves, Laszlo, Mucsi, Jáno, Pauker, Zsolt, Petró, Gizella, Plés, Zsolt, Revesz, Katalin, Sándor, Vangel, Vass, Viktor, Avogaro, Angelo, Boemi, Massimo, Bonadonna, Riccardo, Consoli, Agostino, De Cosmo, Salvatore, Di Bartolo, Paolo, Dotta, Francesco, Frontoni, Simona, Galetta, Marianna, Gambineri, Alessandra, Gazzaruso, Carmine, Giorgino, Francesco, Lauro, Davide, Orsi, Emanuela, Paolisso, Giuseppe, Perriello, Gabriele, Piatti, Piermarco, Pontiroli, Antonio, Ponzani, Paola, Rivellese, Angela Albarosa, Sesti, Giorgio, Tonolo, Giancarlo, Trevisan, Roberto, Ahn, Chul Woo, Baik, Sei-Hyun, Cha, Bong-Soo, Chung, Choon-Hee, Jang, Hak Chul, Kim, Chong-Jin, Kim, Hye Soon, Kim, In Joo, Lee, Eun Young, Lee, Hyoung Woo, Lee, Kwan-Woo, Moon, Keon-Woong, Namgung, June, Park, Kyong Soo, Yoo, Soon Jib, Yu, Jaemyung, Llamas, Edmundo-Alfredo Bayram, Cervantes-Escárcega, Jose-Lui, Flota-Cervera, Luis Fernando, González-González, José Gerardo, Pascoe-Gonzalez, Sara, Pelayo-Orozco, Emilia Susana, Ramirez-Diaz, Santiago-Paulino, Saldana-Mendoza, Arturo, Jerjes-Díaz, Carlos Sánchez, Torres-Colores, Jose Juan, Vidrio-Velázquez, Maricela, Villagordoa-Mesa, Juan, Beijerbacht, Hugo Peter, Groutars, Reginald G. E. J., Hoek, Boudewijn A, Hoogslag, Pieter A. M., Kooy, Adriaan, Kragten, Johannes A., Lieverse, Aloysius G., Swart, Hendrik P., Viergever, Eric P., Ahlqvist, Jørn, Cooper, John, Gulseth, Hanne, Guttormsen, Gaute, Wium, Cecilie, Arbañil, Hugo, Calderon, Jorge, Camacho, Lui, Espinoza, Augusto Dextre, Garrido, Elizabeth, Luna, Alejandro, Manrique, Helard, Revoredo, Frederick Massucco, Gonzales, Rolando Varga, Rincon, Luis Zapata, Zubiate, Carlo, Ebo, Geraldine, Morales-Palomares, Ellen, Arciszewska, Malgorzata, Banach, Marek, Bijata-Bronisz, Renata, Derezinski, Tadeusz, Gadzinski, Waldemar, Gajek, Jacek, Klodawska, Katarzyna, Krzyzagorska, Ewa, Madej, Andrzej, Miekus, Pawel, Opiela, Jaroslaw, Romanczuk, Piotr, Siegel, Anna, Skokowska, Ewa, Stankiewicz, Andrzej, Stasinska, Teresa, Trznadel-Morawska, Iwona, Witek, Robert, Aksentyev, Sergey, Bondar, Irina, Demidova, Irina, Dreval, Alexander, Ershova, Olga, Galstyan, Gagik, Garganeeva, Alla, Izmozherova, Nadezhda, Karetnikova, Victoria, Kharakhulakh, Marina, Khokhlov, Aleksandr, Kobalava, Zhanna, Koshelskaya, Olga, Kosmacheva, Elena, Kostin, Vladimir, Koziolova, Natalia, Kuzin, Anatoly, Lesnov, Victor, Lysenko, Tatyana, Markov, Valentin, Mayorov, Alexander, Moiseev, Sergey, Myasoedova, Svetlana, Petunina, Nina, Rebrov, Andrey, Ruyatkina, Ludmila, Samoylova, Julia, Sazonova, Olga, Shilkina, Natalia, Sokolova, Nadezhda, Vasilevskaya, Olga, Verbovaya, Nelli, Vishneva, Elena, Vorobyev, Sergey, Vorokhobina, Natalya, Zanozina, Olga, Zhdanova, Elena, Zykova, Tatyana, Burgess, Lesley, Coetzee, Kathleen, Dawood, Saleem, Lombard, Landman, Makotoko, Ellen, Moodley, Rajendran, Oosthuysen, Wessel, Sarvan, Mohamed, Calvo Gómez, Carlo, Cano Rodríguez, Isidoro, Castro Conde, Almudena, Cequier Fillat, Angel, Cuatrecasas Cambra, Guillem, de Álvaro Moreno, Fernando, De Teresa Parreño, Lui, Delgado Lista, Javier, Domínguez Escribano, José Ramón, Durán García, Santiago, Elvira González, Javier, Fernández Rodríguez, José María, Goday Arno, Alberto, Gomez Huelgas, Ricardo, González Juanatey, José Ramón, Hernandez Mijares, Antonio, Jiménez Díaz, Víctor Alfonso, Jodar Gimeno, Esteban, Lucas Morante, Tomá, Marazuela, Monica, Martell Claros, Nieve, Mauricio Puente, Didac, Mena Ribas, Elena, Merino Torres, Juan Francisco, Mezquita Raya, Pedro, Nubiola Calonge, Andreu, Ordoñez Sánchez, Xavier, Pascual Izuel, Jose Maria, Perea Castilla, Verónica, Pérez Pérez, Antonio, Perez Soto, Isabel, Quesada Charneco, Miguel, Quesada Simón, Angustia, Redón Mas, Josep, Rego Iraeta, Antonia, Rodriguez Alvarez, Maria, Rodríguez Rodríguez, Irene, Sabán Ruiz, José, Soto González, Alfonso, Tinahones Madueno, Francisco, Trescoli Serrano, Carlo, Ulied Armiñana, Angel, Bachus, Erasmu, Berndtsson Blom, Katarina, Eliasson, Ken, Koskinen, Pekka, Larnefeldt, Han, Lif-Tiberg, Cornelia, Linderfalk, Carina, Lund, Gustav, Lundman, Pia, Moris, Linda, Olsson, Åke, Salmonsson, Staffan, Sanmartin Berglund, Johan, Sjöberg, Folke, Söderberg, Stefan, Torstensson, Ingemar, Chen, Jung-Fu, Tien, Kai Jen, Tseng, Shih-Ting, Tu, Shih-Te, Wang, Chih-Yuan, Wang, Ji-Hung, Phrommintikul, Arintaya, Yamwong, Sukit, Jintapakorn, Woravut, Hutayanon, Pisit, Sansanayudh, Nakarin, Bazhan, Larysa, Fushtey, Ivan, Grachova, Mariya, Katerenchuk, Vitaliy, Korpachev, Vadym, Kravchun, Nonna, Larin, Oleksandr, Mykhalchyshyn, Galyna, Myshanych, Halyna, Oleksyk, Olga, Orlenko, Valeriia, Pashkovska, Nataliia, Pertseva, Nataliia, Petrosyan, Olena, Smirnov, Ivan, Vlasenko, Maryna, Zlova, Tetiana, Aye, Myint, Baksi, Arun, Balasubramani, Mathangi, Beboso, Ronnie, Blagden, Mark, Bundy, Charle, Cookson, Tobia, Copland, Allan, Emslie-Smith, Alistair, Green, Fiona, Gunstone, Anthony, Issa, Basil, Jackson-Voyzey, Ewart, Johnson, Andrew, Maclean, Malcolm, Mcknight, John, Muzulu, Solomon, O'Connell, Ian, Oyesile, Babatunde, Patterson, Catherine, Pearson, Ewan, Philip, Sam, Smith, Paul, Sukumaran, Usha, Abbas, Jalal, Aggarwala, Gaurav, Akhter, Faiq, Andersen, Jame, Anglade, Moise, Argoud, George, Ariani, Mehrdad, Ashdji, Reswan, Bakhtari, Ladan, Banerjee, Subhash, Bartlett, Andrew, Baum, Howard, Bays, Harold, Beasley, Richard, Belfort de Aguiar, Renata, Benjamin, Sabrina, Bhagwat, Ravi, Bhargava, Anuj, Bode, Bruce, Bratcher, Christina, Briskin, Toby, Brockmyre, Andrew, Broughton, Raymond, Brown, Judith, Budhraja, Madhusudan, Cannon, Kevin, Carr, Jewell, Cathcart, Harold, Cavale, Arvind, Chaykin, Loui, Cheung, Deanna, Childress, Richard, Cohen, Allan, Condit, Jonathan, Cooksey, Erin, Cornett, George Mitchell, Dauber, Ira, Davila, William, De Armas, Lui, Dean, Juliu, Detweiler, Robert, Diaz, Ernesto, Di Giovanna, Michael, Dor, Isaac, Drummond, Waymon, Eagerton, Donald, Earl, John, Eaton, Charle, Ellison, Howard, Farris, Neil, Fiel, Thoma, Firek, Anthony, First, Brian, Forgosh, Le, French, William, Gandy, Winston, Garcia, Ronald, Gill, Santosh, Gordon, Murray, Guice, Michael, Gummadi, Siva, Hackenyos, Jonathan, Hairston, Kristen, Hanson, Lenita, Harrison, Lindsay, Hartman, Israel, Heitner, John, Hejeebu, Srini, Hermany, Paul, Hernandez-Cassis, Carlo, Hidalgo, Horacio, Higgins, Alexander, Ibrahim, Hassan, Jacobs, Shahram, Johnson, David, Joshi, Parag, Kaster, Steven, Kellum, Daniel, Kim, Christopher, Kim, Ellen, Kirby, William, Knouse, Albert, Kulback, Steven, Kumar, Mariananda, Kuruvanka, Tulsida, Labroo, Ajay, Lasswell, William, Lentz, John, Lenzmeier, Thoma, Lewis, David, Li, Zhaoping, Lillestol, Michael, Little, Raymond, Lorraine, Richard, McKeown-Biagas, Cecilia, Mcneill, Robert, Mehta, Anand, Miller, Alan, Moran, Joseph, Morawski, Emily, Nadar, Venkatesh, O'Connor, Thoma, Odio, Alberto, Parker, Reginald, Patel, Rajesh, Phillips, Lawrence, Raad, George, Rahman, Aref, Raikhel, Marina, Raisinghani, Ajit, Rajan, Raj, Rasouli, Neda, Rauzi, Frank, Rohr, Kathryn, Roseman, Hal, Rovner, Sergio, Saba, Fadi, Sachson, Richard, Schabauer, Alex, Schneider, Ricky, Schuchard, Timothy, Sensenbrenner, John, Shlesinger, Yshay, Singh, Narendra, Sivalingam, Kanagaratnam, Stonesifer, Larry, Storey, Daniel, Suh, David, Tahir, Mohammed, Tan, Anjanette, Tan, Marilyn, Taylon, Alain, Thakkar, Maitreya, Tripathy, Devjit, Uwaifo, Gabriel, Vedere, Amarnath, Venugopal, Chandra, Vo, Anthony, Welch, Michelle, Welker, Jame, White, Alexander, Willis, John, Wynne, Alan, Yazdani, Shahram, Rosenberg, Anne, Price, Lauren, Sigmon, Kristina, Lokhngina, Yuliya, Xing, Weibing, Overton, Robert, Stewart, Murray, Stead, Janet, Lindsay, Alistair, Patel, Vicka, Ross, Jorge, Soffer, Joseph, Daga, Shruti, Sowell, Margaret, Patel, Prashant, Garvey, Louisa, Ackert, Jessica, Abraham, Sybil, Sabol, Mary Beth, Altobelli, Desma, Ha, Juyoung, Kulkarni, Mangesh, Somerville, Matthew, Noronha, Drusilla, Casson, Ed, Zang, Eddie, Sandhu, Chamandeep, Kumar, Rakesh, Chen, David, Taft, Lin, Patel, Rajivkumar, Ye, June, Shannon, Jennifer, Wilson, Tim, Babi, Charleen, Miller, Diane, Thorpe, Karl, Russell, Rachael, Bull, Georgina, Hereghty, Belinda, Fernandez-Salazar, Eva, Longley, Troy, Donaldson, Jill, Jarosz, Marie, Murphy, Karen, Adams, Patricia, Smith, Peter, James, Rachel, Richards, Jackie, Sedani, Sangeeta, Althouse, Denise, Watson, David, Lorimer, Jamie, Lauder, Steven, Schultheis, Ron, Womer, Terese, Wraight, Ella, Li, Wenyan, Price-Olsen, Emma, Watson, Anthony, Kelly, Aoife, Mclaughlin, Patricia, Fleming, John, Schubert, Jessica, Schleiden, Debra, Harris, Tara, Prakash, Rahul, Breneman, Jody, Deshpande, Sameer, Saswadkar, Aarti, Kumari, Aditi, Shitut, Aditi, Raorane, Amruta, Karmalkar, Anisha, Mhambrey, Ankita, Bhosale, Archana, Vaphare, Ashok, Patil, Ashwini P, Khandelwal, Chaitali, Shaik, Fayaz, Nadar, Madhumitha, Karka, Mounika, Kadgaonkar, Neha, Gupta, Nikita, Aher, Nutan, Potnis, Omkar, Naicker, Pallavi, Shinde, Rakesh, Sharma, Richa, Godse, Rupali, Solanki, Sheetal, Sahu, Shruti, Dumbre, Snehal, Kumar, Somesh, Patil, Suradnya, Mandal, Trisha, and Giaccari, Andrea (ORCID:0000-0002-7462-7792)

Abstract

Background: Glucagon-like peptide 1 receptor agonists differ in chemical structure, duration of action, and in their effects on clinical outcomes. The cardiovascular effects of once-weekly albiglutide in type 2 diabetes are unknown. We aimed to determine the safety and efficacy of albiglutide in preventing cardiovascular death, myocardial infarction, or stroke. Methods: We did a double-blind, randomised, placebo-controlled trial in 610 sites across 28 countries. We randomly assigned patients aged 40 years and older with type 2 diabetes and cardiovascular disease (at a 1:1 ratio) to groups that either received a subcutaneous injection of albiglutide (30–50 mg, based on glycaemic response and tolerability) or of a matched volume of placebo once a week, in addition to their standard care. Investigators used an interactive voice or web response system to obtain treatment assignment, and patients and all study investigators were masked to their treatment allocation. We hypothesised that albiglutide would be non-inferior to placebo for the primary outcome of the first occurrence of cardiovascular death, myocardial infarction, or stroke, which was assessed in the intention-to-treat population. If non-inferiority was confirmed by an upper limit of the 95% CI for a hazard ratio of less than 1·30, closed testing for superiority was prespecified. This study is registered with ClinicalTrials.gov, number NCT02465515. Findings: Patients were screened between July 1, 2015, and Nov 24, 2016. 10 793 patients were screened and 9463 participants were enrolled and randomly assigned to groups: 4731 patients were assigned to receive albiglutide and 4732 patients to receive placebo. On Nov 8, 2017, it was determined that 611 primary endpoints and a median follow-up of at least 1·5 years had accrued, and participants returned for a final visit and discontinuation from study treatment; the last patient visit was on March 12, 2018. These 9463 patients, the intention-to-treat population, were

Published
2018

41. Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial

Author

Hernandez, Adrian F, primary, Green, Jennifer B, additional, Janmohamed, Salim, additional, D'Agostino, Ralph B, additional, Granger, Christopher B, additional, Jones, Nigel P, additional, Leiter, Lawrence A, additional, Rosenberg, Anne E, additional, Sigmon, Kristina N, additional, Somerville, Matthew C, additional, Thorpe, Karl M, additional, McMurray, John J V, additional, Del Prato, Stefano, additional, McMurray, John J.V., additional, D'Agostino, Ralph B., additional, Granger, Christopher B., additional, Hernandez, Adrian F., additional, Leiter, Lawrence A., additional, Califf, Robert M, additional, Holman, Rury, additional, DeMets, David, additional, Riddle, Matthew, additional, Goodman, Shaun, additional, McGuire, Darren, additional, Alexander, Karen, additional, Devore, Adam, additional, Melloni, Chiara, additional, Patel, Chetan, additional, Kong, David, additional, Bloomfield, Gerald, additional, Roe, Matthew, additional, Tricoci, Pierluigi, additional, Harrison, Rob, additional, Lopes, Renato, additional, Mathews, Robin, additional, Mehta, Rajendra, additional, Schuyler Jones, William, additional, Vemulapalli, Sreekanth, additional, Povsic, Thomas, additional, Eapen, Zubin, additional, Dombrowski, Keith, additional, Kolls, Brad, additional, Jordan, Dedrick, additional, Ambrosy, Andrew, additional, Greene, Stephen, additional, Mandawat, Aditya, additional, Shavadia, Jay, additional, Cooper, Lauren, additional, Sharma, Abhinav, additional, Guimaraes, Patricia, additional, Friedman, Daniel, additional, Wilson, Matt, additional, Endsley, Patricia, additional, Gentry, Tracy, additional, Collier, Jeannie, additional, Perez, Kathleen, additional, James, Kourtnei, additional, Roush, Jennifer, additional, Pope, Connie, additional, Howell, Christina, additional, Johnson, Megan, additional, Bailey, Matt, additional, Cole, Joanna, additional, Akers, Teresa, additional, Vandyne, Beth, additional, Thomas, Betsy, additional, Rich, Jenny, additional, Bartone, Susan, additional, Beaulieu, Gail, additional, Brown, Kim, additional, Chau, Tuan, additional, Christian, Tamra, additional, Coker, Rebecca, additional, Greene, Deb, additional, Haddock, Trevorlyn, additional, Jenkins, Wendy, additional, Haque, Ghazala, additional, Marquess, Marsha, additional, Pesarchick, Jean, additional, Rethaford, Renee, additional, Stone, Allegra, additional, Al Kawas, Firas, additional, Anderson, Michelle, additional, Enns, Robert, additional, Sinay, Isaac, additional, Mathieu, Chantal, additional, Yordanov, Victor, additional, Hramiak, Irene, additional, Haluzik, Martin, additional, Galatius, Søren, additional, Guerci, Bruno, additional, Nauck, Michael, additional, Migdalis, Ilias, additional, Tan, Choon Beng Kathryn, additional, Kocsis, Gyozo, additional, Giaccari, Andrea, additional, Lee, Moon Kyu, additional, Muñoz, Ernesto German Cardona, additional, Cornel, Jan, additional, Birkeland, Kare, additional, Pinto, Miguel, additional, Tirador, Louie, additional, Olesinska-Mader, Martyna, additional, Shestakova, Marina, additional, Distiller, Larry, additional, Lopez-Sendon, Jose, additional, Eliasson, Bjorn, additional, Chiang, Chern-En, additional, Srimahachota, Suphot, additional, Mankovsky, Boris, additional, Bethel, M Angelyn, additional, Dungan, Kathleen, additional, Kosiborod, Mikhail, additional, Alvarisqueta, Andres, additional, Baldovino, Jorge, additional, Besada, Diego, additional, Calella, Pedro, additional, Cantero, Maria Cecilia, additional, Castaño, Patricia, additional, Chertkoff, Alejandro, additional, Cuadrado, Jesus, additional, De Loredo, Luis, additional, Dominguez, Andrea, additional, Español, Maria Vanesa, additional, Finkelstein, Hernan, additional, Frechtel, Gustavo, additional, Fretes, Jose, additional, Garrido Santos, Natalia, additional, Gonzalez, Joaquin, additional, Litvak, Marcos, additional, Loureyro, Juan, additional, Maffei, Laura, additional, Maldonado, Natacha, additional, Mohr Gasparini, Diego, additional, Orio, Silvia, additional, Perez Manghi, Federico, additional, Rodriguez Papini, Nelson, additional, Sala, Jorgelina, additional, Schygiel, Pablo, additional, Sposetti, Georgina, additional, Ulla, Maria, additional, Verra, Fernando, additional, Zabalua, Silvina, additional, Zaidman, Cesar, additional, Crenier, Laurent, additional, Debroye, Corinne, additional, Duyck, Francis, additional, Scheen, André, additional, Van Gaal, Luc, additional, Vercammen, Chris, additional, Damyanova, Velichka, additional, Dimitrov, Stefan, additional, Kovacheva, Snezhina, additional, Lozanov, Lachezar, additional, Margaritov, Viktor, additional, Mihaylova-Shumkova, Rositsa, additional, Nikolaeva, Antoaneta, additional, Stoyanova, Zhasmina, additional, Akhras, Ronald, additional, Beaudry, Yves, additional, Bedard, Jacques, additional, Berlingieri, Joseph, additional, Chehayeb, Raja, additional, Cheung, Stephen, additional, Conway, James, additional, Cusson, Jean, additional, Della Siega, Anthony, additional, Dumas, Richard, additional, Dzongowski, Peter, additional, Ferguson, Murdo, additional, Gaudet, Daniel, additional, Grondin, Francois, additional, Gupta, Anil, additional, Gupta, Milan, additional, Halperin, Frank, additional, Houle, Pierre-Alain, additional, Jones, Michael, additional, Kouz, Simon, additional, Kovacs, Christopher, additional, Landry, Daniel, additional, Lonn, Eva, additional, O'Mahony, William, additional, Peterson, Sean, additional, Reich, Dennis, additional, Rosenbloom, Alan, additional, St-Maurice, Francois, additional, Tugwell, Barna, additional, Vizel, Saul, additional, Woo, Vincent, additional, Brychta, Tomas, additional, Cech, Vladimir, additional, Dvorakova, Eva, additional, Edelsberger, Tomas, additional, Halciakova, Katarina, additional, Krizova, Jarmila, additional, Lastuvka, Jiri, additional, Piperek, Martin, additional, Prymkova, Vera, additional, Raclavska, Lea, additional, Silhova, Elena, additional, Urbanek, Robin, additional, Vrkoc, Jan, additional, Andersen, Ulla, additional, Brønnum-Schou, Jens, additional, Hove, Jens, additional, Jensen, Jan Skov, additional, Kober, Lars, additional, Kristiansen, Ole Peter, additional, Lund, Per, additional, Melchior, Thomas, additional, Nyvad, Ole, additional, Schou, Morten, additional, Boye, Alain, additional, Cadinot, Didier, additional, Gouet, Didier, additional, Henry, Patrick, additional, Kessler, Laurence, additional, Lalau, Jean-Daniel, additional, Petit, Catherine, additional, Thuan, Jean-Francois, additional, Voinot, Christel, additional, Vouillarmet, Julien, additional, Axthelm, Christoph, additional, Berger, Dirk, additional, Bieler, Tasso, additional, Birkenfeld, Andreas, additional, Bott, Jochen, additional, Busch, Klaus, additional, Caca, Karel, additional, Chevts, Julia, additional, Donaubauer, Torsten, additional, Erlinger, Rudolf, additional, Funke, Klaus, additional, Grosskopf, Josef, additional, Hagenow, Andreas, additional, Hamann, Monika, additional, Hartard, Manfred, additional, Heymer, Peter, additional, Huppertz, Wolfgang, additional, Illies, Gabriele, additional, Jacob, Stephan, additional, Jung, Thomas, additional, Kahrmann, Gerd, additional, Kast, Petra, additional, Kellerer, Monika, additional, Kempe, Hans-Peter, additional, Khariouzov, Andrei, additional, Klausmann, Gerhard, additional, Klein, Christiane, additional, Kleinecke-Pohl, Uwe, additional, Kleinertz, Klaus, additional, Koch, Thorsten, additional, Kosch, Christine, additional, Lorra, Babette, additional, Luedemann, Joerg, additional, Luttermann, Matthias, additional, Maxeiner, Stephan, additional, Milek, Karsten, additional, Moelle, Andrea, additional, Neumann, Gerhard, additional, Nischik, Ruth, additional, Oehrig-Pohl, Edith, additional, Plassmann, Georg, additional, Pohlmeier, Lars, additional, Proepper, Felix, additional, Regner, Stefan, additional, Rieker, Werner, additional, Rose, Ludger, additional, Samer, Holger, additional, Sauter, Joachim, additional, Schaper, Frank, additional, Schiffer, Clemens, additional, Schmidt, Juergen, additional, Scholz, Bernd-M., additional, Schulze, Joerg, additional, Segner, Alexander, additional, Seufert, Jochen, additional, Sigal, Helena, additional, Steindorf, Joerg, additional, Stockhausen, Juergen, additional, Stuebler, Petra, additional, Taeschner, Heidrun, additional, Tews, Dietrich, additional, Tschoepe, Diethelm, additional, Wilhelm, Karl, additional, Zeller-Stefan, Helga, additional, Avramidis, Iakovos, additional, Bousboulas, Stavros, additional, Bristianou, Magdalini, additional, Dimitriadis, Georgios, additional, Elisaf, Moses, additional, Kotsa, Kalliopi, additional, Melidonis, Andreas, additional, Mitrakou, Asimina, additional, Pagkalos, Emmanouil, additional, Papanas, Nikolaos, additional, Pappas, Angelos, additional, Sampanis, Christos, additional, Tentolouris, Nikolaos, additional, Tsapas, Apostolos, additional, Tzatzagou, Glykeria, additional, Ozaki, Risa, additional, Hajdú, Csaba, additional, Harcsa, Eleonóra, additional, Konyves, Laszlo, additional, Mucsi, János, additional, Pauker, Zsolt, additional, Petró, Gizella, additional, Plés, Zsolt, additional, Revesz, Katalin, additional, Sándor, Vangel, additional, Vass, Viktor, additional, Avogaro, Angelo, additional, Boemi, Massimo, additional, Bonadonna, Riccardo, additional, Consoli, Agostino, additional, De Cosmo, Salvatore, additional, Di Bartolo, Paolo, additional, Dotta, Francesco, additional, Frontoni, Simona, additional, Galetta, Marianna, additional, Gambineri, Alessandra, additional, Gazzaruso, Carmine, additional, Giorgino, Francesco, additional, Lauro, Davide, additional, Orsi, Emanuela, additional, Paolisso, Giuseppe, additional, Perriello, Gabriele, additional, Piatti, Piermarco, additional, Pontiroli, Antonio, additional, Ponzani, Paola, additional, Rivellese, Angela Albarosa, additional, Sesti, Giorgio, additional, Tonolo, Giancarlo, additional, Trevisan, Roberto, additional, Ahn, Chul Woo, additional, Baik, Sei-Hyun, additional, Cha, Bong-Soo, additional, Chung, Choon-Hee, additional, Jang, Hak Chul, additional, Kim, Chong-Jin, additional, Kim, Hye Soon, additional, Kim, In Joo, additional, Lee, Eun Young, additional, Lee, Hyoung Woo, additional, Lee, Kwan-Woo, additional, Moon, Keon-Woong, additional, Namgung, June, additional, Park, Kyong Soo, additional, Yoo, Soon Jib, additional, Yu, Jaemyung, additional, Llamas, Edmundo-Alfredo Bayram, additional, Cervantes-Escárcega, Jose-Luis, additional, Flota-Cervera, Luis Fernando, additional, González-González, José Gerardo, additional, Pascoe-Gonzalez, Sara, additional, Pelayo-Orozco, Emilia Susana, additional, Ramirez-Diaz, Santiago-Paulino, additional, Saldana-Mendoza, Arturo, additional, Jerjes-Díaz, Carlos Sánchez, additional, Torres-Colores, Jose Juan, additional, Vidrio-Velázquez, Maricela, additional, Villagordoa-Mesa, Juan, additional, Beijerbacht, Hugo Peter, additional, Groutars, Reginald G.E.J., additional, Hoek, Boudewijn A, additional, Hoogslag, Pieter A.M., additional, Kooy, Adriaan, additional, Kragten, Johannes A., additional, Lieverse, Aloysius G., additional, Swart, Hendrik P., additional, Viergever, Eric P., additional, Ahlqvist, Jørn, additional, Cooper, John, additional, Gulseth, Hanne, additional, Guttormsen, Gaute, additional, Wium, Cecilie, additional, Arbañil, Hugo, additional, Calderon, Jorge, additional, Camacho, Luis, additional, Espinoza, Augusto Dextre, additional, Garrido, Elizabeth, additional, Luna, Alejandro, additional, Manrique, Helard, additional, Revoredo, Frederick Massucco, additional, Gonzales, Rolando Vargas, additional, Rincon, Luis Zapata, additional, Zubiate, Carlos, additional, Ebo, Geraldine, additional, Morales-Palomares, Ellen, additional, Arciszewska, Malgorzata, additional, Banach, Marek, additional, Bijata-Bronisz, Renata, additional, Derezinski, Tadeusz, additional, Gadzinski, Waldemar, additional, Gajek, Jacek, additional, Klodawska, Katarzyna, additional, Krzyzagorska, Ewa, additional, Madej, Andrzej, additional, Miekus, Pawel, additional, Opiela, Jaroslaw, additional, Romanczuk, Piotr, additional, Siegel, Anna, additional, Skokowska, Ewa, additional, Stankiewicz, Andrzej, additional, Stasinska, Teresa, additional, Trznadel-Morawska, Iwona, additional, Witek, Robert, additional, Aksentyev, Sergey, additional, Bondar, Irina, additional, Demidova, Irina, additional, Dreval, Alexander, additional, Ershova, Olga, additional, Galstyan, Gagik, additional, Garganeeva, Alla, additional, Izmozherova, Nadezhda, additional, Karetnikova, Victoria, additional, Kharakhulakh, Marina, additional, Khokhlov, Aleksandr, additional, Kobalava, Zhanna, additional, Koshelskaya, Olga, additional, Kosmacheva, Elena, additional, Kostin, Vladimir, additional, Koziolova, Natalia, additional, Kuzin, Anatoly, additional, Lesnov, Victor, additional, Lysenko, Tatyana, additional, Markov, Valentin, additional, Mayorov, Alexander, additional, Moiseev, Sergey, additional, Myasoedova, Svetlana, additional, Petunina, Nina, additional, Rebrov, Andrey, additional, Ruyatkina, Ludmila, additional, Samoylova, Julia, additional, Sazonova, Olga, additional, Shilkina, Natalia, additional, Sokolova, Nadezhda, additional, Vasilevskaya, Olga, additional, Verbovaya, Nelli, additional, Vishneva, Elena, additional, Vorobyev, Sergey, additional, Vorokhobina, Natalya, additional, Zanozina, Olga, additional, Zhdanova, Elena, additional, Zykova, Tatyana, additional, Burgess, Lesley, additional, Coetzee, Kathleen, additional, Dawood, Saleem, additional, Lombard, Landman, additional, Makotoko, Ellen, additional, Moodley, Rajendran, additional, Oosthuysen, Wessels, additional, Sarvan, Mohamed, additional, Calvo Gómez, Carlos, additional, Cano Rodríguez, Isidoro, additional, Castro Conde, Almudena, additional, Cequier Fillat, Angel, additional, Cuatrecasas Cambra, Guillem, additional, de Álvaro Moreno, Fernando, additional, De Teresa Parreño, Luis, additional, Delgado Lista, Javier, additional, Domínguez Escribano, José Ramón, additional, Durán García, Santiago, additional, Elvira González, Javier, additional, Fernández Rodríguez, José María, additional, Goday Arno, Alberto, additional, Gomez Huelgas, Ricardo, additional, González Juanatey, José Ramón, additional, Hernandez Mijares, Antonio, additional, Jiménez Díaz, Víctor Alfonso, additional, Jodar Gimeno, Esteban, additional, Lucas Morante, Tomás, additional, Marazuela, Monica, additional, Martell Claros, Nieves, additional, Mauricio Puente, Didac, additional, Mena Ribas, Elena, additional, Merino Torres, Juan Francisco, additional, Mezquita Raya, Pedro, additional, Nubiola Calonge, Andreu, additional, Ordoñez Sánchez, Xavier, additional, Pascual Izuel, Jose Maria, additional, Perea Castilla, Verónica, additional, Pérez Pérez, Antonio, additional, Perez Soto, Isabel, additional, Quesada Charneco, Miguel, additional, Quesada Simón, Angustias, additional, Redón Mas, Josep, additional, Rego Iraeta, Antonia, additional, Rodriguez Alvarez, Maria, additional, Rodríguez Rodríguez, Irene, additional, Sabán Ruiz, José, additional, Soto González, Alfonso, additional, Tinahones Madueno, Francisco, additional, Trescoli Serrano, Carlos, additional, Ulied Armiñana, Angels, additional, Bachus, Erasmus, additional, Berndtsson Blom, Katarina, additional, Eliasson, Ken, additional, Koskinen, Pekka, additional, Larnefeldt, Hans, additional, Lif-Tiberg, Cornelia, additional, Linderfalk, Carina, additional, Lund, Gustav, additional, Lundman, Pia, additional, Moris, Linda, additional, Olsson, Åke, additional, Salmonsson, Staffan, additional, Sanmartin Berglund, Johan, additional, Sjöberg, Folke, additional, Söderberg, Stefan, additional, Torstensson, Ingemar, additional, Chen, Jung-Fu, additional, Tien, Kai Jen, additional, Tseng, Shih-Ting, additional, Tu, Shih-Te, additional, Wang, Chih-Yuan, additional, Wang, Ji-Hung, additional, Phrommintikul, Arintaya, additional, Yamwong, Sukit, additional, Jintapakorn, Woravut, additional, Hutayanon, Pisit, additional, Sansanayudh, Nakarin, additional, Bazhan, Larysa, additional, Fushtey, Ivan, additional, Grachova, Mariya, additional, Katerenchuk, Vitaliy, additional, Korpachev, Vadym, additional, Kravchun, Nonna, additional, Larin, Oleksandr, additional, Mykhalchyshyn, Galyna, additional, Myshanych, Halyna, additional, Oleksyk, Olga, additional, Orlenko, Valeriia, additional, Pashkovska, Nataliia, additional, Pertseva, Nataliia, additional, Petrosyan, Olena, additional, Smirnov, Ivan, additional, Vlasenko, Maryna, additional, Zlova, Tetiana, additional, Aye, Myint, additional, Baksi, Arun, additional, Balasubramani, Mathangi, additional, Beboso, Ronnie, additional, Blagden, Mark, additional, Bundy, Charles, additional, Cookson, Tobias, additional, Copland, Allan, additional, Emslie-Smith, Alistair, additional, Green, Fiona, additional, Gunstone, Anthony, additional, Issa, Basil, additional, Jackson-Voyzey, Ewart, additional, Johnson, Andrew, additional, Maclean, Malcolm, additional, McKnight, John, additional, Muzulu, Solomon, additional, O'Connell, Ian, additional, Oyesile, Babatunde, additional, Patterson, Catherine, additional, Pearson, Ewan, additional, Philip, Sam, additional, Smith, Paul, additional, Sukumaran, Usha, additional, Abbas, Jalal, additional, Aggarwala, Gaurav, additional, Akhter, Faiq, additional, Andersen, James, additional, Anglade, Moise, additional, Argoud, Georges, additional, Ariani, Mehrdad, additional, Ashdji, Reswan, additional, Bakhtari, Ladan, additional, Banerjee, Subhash, additional, Bartlett, Andrew, additional, Baum, Howard, additional, Bays, Harold, additional, Beasley, Richard, additional, Belfort de Aguiar, Renata, additional, Benjamin, Sabrina, additional, Bhagwat, Ravi, additional, Bhargava, Anuj, additional, Bode, Bruce, additional, Bratcher, Christina, additional, Briskin, Toby, additional, Brockmyre, Andrew, additional, Broughton, Raymond, additional, Brown, Judith, additional, Budhraja, Madhusudan, additional, Cannon, Kevin, additional, Carr, Jewell, additional, Cathcart, Harold, additional, Cavale, Arvind, additional, Chaykin, Louis, additional, Cheung, Deanna, additional, Childress, Richard, additional, Cohen, Allan, additional, Condit, Jonathan, additional, Cooksey, Erin, additional, Cornett, George Mitchell, additional, Dauber, Ira, additional, Davila, William, additional, De Armas, Luis, additional, Dean, Julius, additional, Detweiler, Robert, additional, Diaz, Ernesto, additional, Di Giovanna, Michael, additional, Dor, Isaac, additional, Drummond, Waymon, additional, Eagerton, Donald, additional, Earl, John, additional, Eaton, Charles, additional, Ellison, Howard, additional, Farris, Neil, additional, Fiel, Thomas, additional, Firek, Anthony, additional, First, Brian, additional, Forgosh, Les, additional, French, William, additional, Gandy, Winston, additional, Garcia, Ronald, additional, Gill, Santosh, additional, Gordon, Murray, additional, Guice, Michael, additional, Gummadi, Siva, additional, Hackenyos, Jonathan, additional, Hairston, Kristen, additional, Hanson, Lenita, additional, Harrison, Lindsay, additional, Hartman, Israel, additional, Heitner, John, additional, Hejeebu, Srini, additional, Hermany, Paul, additional, Hernandez-Cassis, Carlos, additional, Hidalgo, Horacio, additional, Higgins, Alexander, additional, Ibrahim, Hassan, additional, Jacobs, Shahram, additional, Johnson, David, additional, Joshi, Parag, additional, Kaster, Steven, additional, Kellum, Daniel, additional, Kim, Christopher, additional, Kim, Ellen, additional, Kirby, William, additional, Knouse, Albert, additional, Kulback, Steven, additional, Kumar, Mariananda, additional, Kuruvanka, Tulsidas, additional, Labroo, Ajay, additional, Lasswell, William, additional, Lentz, John, additional, Lenzmeier, Thomas, additional, Lewis, David, additional, Li, Zhaoping, additional, Lillestol, Michael, additional, Little, Raymond, additional, Lorraine, Richard, additional, McKeown-Biagas, Cecilia, additional, McNeill, Robert, additional, Mehta, Anand, additional, Miller, Alan, additional, Moran, Joseph, additional, Morawski, Emily, additional, Nadar, Venkatesh, additional, O'Connor, Thomas, additional, Odio, Alberto, additional, Parker, Reginald, additional, Patel, Rajesh, additional, Phillips, Lawrence, additional, Raad, George, additional, Rahman, Aref, additional, Raikhel, Marina, additional, Raisinghani, Ajit, additional, Rajan, Raj, additional, Rasouli, Neda, additional, Rauzi, Frank, additional, Rohr, Kathryn, additional, Roseman, Hal, additional, Rovner, Sergio, additional, Saba, Fadi, additional, Sachson, Richard, additional, Schabauer, Alex, additional, Schneider, Ricky, additional, Schuchard, Timothy, additional, Sensenbrenner, John, additional, Shlesinger, Yshay, additional, Singh, Narendra, additional, Sivalingam, Kanagaratnam, additional, Stonesifer, Larry, additional, Storey, Daniel, additional, Suh, David, additional, Tahir, Mohammed, additional, Tan, Anjanette, additional, Tan, Marilyn, additional, Taylon, Alain, additional, Thakkar, Maitreya, additional, Tripathy, Devjit, additional, Uwaifo, Gabriel, additional, Vedere, Amarnath, additional, Venugopal, Chandra, additional, Vo, Anthony, additional, Welch, Michelle, additional, Welker, James, additional, White, Alexander, additional, Willis, John, additional, Wynne, Alan, additional, Yazdani, Shahram, additional, Rosenberg, Anne, additional, Price, Lauren, additional, Sigmon, Kristina, additional, Lokhngina, Yuliya, additional, Xing, Weibing, additional, Overton, Robert, additional, Stewart, Murray, additional, Stead, Janet, additional, Lindsay, Alistair, additional, Patel, Vickas, additional, Ross, Jorge, additional, Soffer, Joseph, additional, Daga, Shruti, additional, Sowell, Margaret, additional, Patel, Prashant, additional, Garvey, Louisa, additional, Ackert, Jessica, additional, Abraham, Sybil, additional, Sabol, Mary Beth, additional, Altobelli, Desma, additional, Ha, JuYoung, additional, Kulkarni, Mangesh, additional, Somerville, Matthew, additional, Noronha, Drusilla, additional, Casson, Ed, additional, Zang, Eddie, additional, Sandhu, Chamandeep, additional, Kumar, Rakesh, additional, Chen, David, additional, Taft, Lin, additional, Patel, Rajivkumar, additional, Ye, June, additional, Shannon, Jennifer, additional, Wilson, Tim, additional, Babi, Charleen, additional, Miller, Diane, additional, Thorpe, Karl, additional, Russell, Rachael, additional, Bull, Georgina, additional, Hereghty, Belinda, additional, Fernandez-Salazar, Eva, additional, Longley, Troy, additional, Donaldson, Jill, additional, Jarosz, Marie, additional, Murphy, Karen, additional, Adams, Patricia, additional, Smith, Peter, additional, James, Rachel, additional, Richards, Jackie, additional, Sedani, Sangeeta, additional, Althouse, Denise, additional, Watson, David, additional, Lorimer, Jamie, additional, Lauder, Steven, additional, Schultheis, Ron, additional, Womer, Terese, additional, Wraight, Ella, additional, Li, Wenyan, additional, Price-Olsen, Emma, additional, Watson, Anthony, additional, Kelly, Aoife, additional, McLaughlin, Patricia, additional, Fleming, John, additional, Schubert, Jessica, additional, Schleiden, Debra, additional, Harris, Tara, additional, Prakash, Rahul, additional, Breneman, Jody, additional, Deshpande, Sameer, additional, Saswadkar, Aarti, additional, Kumari, Aditi, additional, Shitut, Aditi, additional, Raorane, Amruta, additional, Karmalkar, Anisha, additional, Mhambrey, Ankita, additional, Bhosale, Archana, additional, Vaphare, Ashok, additional, Patil, Ashwini P, additional, Khandelwal, Chaitali, additional, Shaik, Fayaz, additional, Nadar, Madhumitha, additional, Karka, Mounika, additional, Kadgaonkar, Neha, additional, Gupta, Nikita, additional, Aher, Nutan, additional, Potnis, Omkar, additional, Naicker, Pallavi, additional, Shinde, Rakesh, additional, Sharma, Richa, additional, Godse, Rupali, additional, Solanki, Sheetal, additional, Sahu, Shruti, additional, Dumbre, Snehal, additional, Kumar, Somesh, additional, Patil, Suradnya, additional, and Mandal, Trisha, additional

Published
2018
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42. Dietary intake and major food sources of polyphenols in people with type 2 diabetes: The TOSCA.IT Study

Author

Vitale, M., Masulli, M., Rivellese, A. A., Bonora, E., Cappellini, F., Nicolucci, Andrea, Squatrito, S., Antenucci, D., Barrea, A., Bianchi, C., Bianchini, F., Fontana, L., Fornengo, P., Giorgino, F., Gnasso, A., Mannucci, E., Mazzotti, A., Nappo, R., Palena, A. P., Pata, P., Perriello, G., Potenziani, S., Radin, R., Ricci, L., Romeo, F., Santini, C., Scarponi, M., Serra, Riccardo, Timi, A., Turco, A. A., Vedovato, M., Zavaroni, D., Grioni, S., Riccardi, G., Vaccaro, O., Rivellese, Angela Albarosa, Cocozza, Sara, Auciello, Stefania, Turco, Anna Amelia, Bonora, Enzo, Cigolini, Massimo, Pichiri, Isabella, Brangani, Corinna, Tomasetto, Elena, Perriello, Gabriele, Timi, Alessia, Squatrito, Sebastiano, Sinagra, Tiziana, Longhitano, Sara, Tropea, Vanessa, Ballardini, Giorgio, Babini, Anna Carla, Ripani, Raffaella, Gregori, Giovanna, Dolci, Maria, Bruselli, Laura, Salutini, Isabella, Mori, Mary, Baccetti, Fabio, Lapolla, Annunziata, Sartore, Giovanni, Burlina, Silvia, Chilelli, Nino Cristiano, Buzzetti, Raffaella, Venditti, Chiara, Potenziani, Stella, Carlone, Angela, Galluzzoâ€&nbsp, Aldo, Giordano, Carla, Torregrossa, Vittoria, Corsi, Laura, Cuneo, Giacomo, Corsi, Simona, Tizio, Biagio, Clemente, Gennaro, Citro, Giuseppe, Natale, Maria, Salvatore, Vita, Di Cianni, Graziano, Lacaria, Emilia, Russo, Laura, Iannarelli, Rossella, de Gregorio, Antonella, Sciarretta, Filomena, D’Andrea, Settimio, Montani, Valeria, Cannarsa, Emanuela, Dolcetti, Katia, Cordera, Renzo, Bonabello, Laura Affinito, Mazzucchelli, Chiara, Giorda, Carlo Bruno, Romeo, Francesco, Bonetto, Caterina, Antenucci, Daniela, Baldassarre, Maria Pompea Antonia, Iovine, Ciro, Nappo, Rossella, Ciano, Ornella, Dall’Aglio, Elisabetta, Mancastroppa, Giovanni, Grimaldi, Franco, Tonutti, Laura, Boemi, Massimo, D’Angelo, Federica, Leotta, Sergio, Fontana, Lucia, Lauro, Davide, Rinaldi, Maria Elena, Cignarelli, Mauro, la Macchia, Olga, Fariello, Stefania, Tomasi, Franco, Zamboni, Chiara, Dozio, Nicoletta, Trevisan, Roberto, Scaranna, Cristiana, Del Prato, Stefano, Miccoli, Roberto, Bianchi, Cristina, Garofolo, Monia, Pugliese, Giuseppe, Salvi, Laura, Rangel, Graziela, Vitale, Martina, Anichini, Roberto, Tedeschi, Anna, Corsini, Elisa, Cucinotta, Domenico, Di Benedetto, Antonino, Giunta, Loretta, Ruffo, Maria Concetta, Bossi, Antonio Carlo, Carpinter, Rita, Dotta, Francesco, Ceccarelli, Elena, Bartolo, Paolo Di, Caselli, Chiara, Luberto, Alessandra, Santini, Costanza, Mazzotti, Arianna, Calbucci, Giovanni, Consoli, Agostino, Ginestra, Federica, Calabrese, Maria, Zogheri, Alessia, Ricci, Lucia, Giorgino, Francesco, Laviola, Luigi, Ippolito, Claudia, Tarantino, Lucia, Avogaro, Angelo, Vedovato, Monica, Gnasso, Agostino, Carallo, Claudio, Scicchitano, Caterina, Zavaroni, Donatella, Livraga, Stefania, Perin, Paolo Cavallo, Forrnengo, Paolo, Prinzis, Tania, de Cosmo, Salvatore, Palena, Antonio Pio, Bacci, Simonetta, Mannucci, Edoardo, Lamanna, Caterina, Pata, Pietro, Lettina, Gabriele, Aiello, Antimo, Barrea, Angelina, Lalli, Carlo, Scarponi, Maura, Franzetti, Ivano, Radin, Raffaella, Serra, Rosalia, Petrachi, Francesca, Asprino, Vincenzo, Capra, Claudio, Forte, Elisa, Reggiani, Giulio Marchesini, Forlani, Gabriele, Montesi, Luca, Mazzella, Natalia, Piatti, Pier Marco, Monti, Lucilla, Stuccillo, Michela, Auletta, Pasquale, Petraroli, Ettore, Capobianco, Giuseppe, Romano, Geremia, Cutolo, Michele, de Simone, Giosetta, Caiazzo, Gennaro, Nunziata, Peppe, Sorrentino, Susy, Amelia, Umberto, Calatola, Pasqualino, Capuano, Gelsomina, Vitale, M, Masulli, M, Rivellese, AA, Bonora, E, Cappellini, F, Nicolucci, A, Squatrito, S, Antenucci, D, Barrea, A, Bianchi, C, Bianchini, F, Fontana, L, Fornengo,P, Giorgino, F, Gnasso, A, Mannucci, Mazzotti, A, Nappo, R, Palena, AP, Pata, P,Perriello, G, Potenziani, S, Radin, R, Ricci, L, Romeo, F, Santini, C, Scarponi, M, Serra, R, Timi, A, Turco, AA, Vedovato, M, Zavaroni, D, Grioni, S, Riccardi, G, Vaccaro, O, TOSCA.IT Study Group., Giordano, C., Rivellese, Aa, Fornengo, P, Mannucci, E, Mazzotti, A, Nappo, R, Palena, Ap, Pata, P, Perriello, G, Turco, Aa, Tosc, A. IT Study Group., Rivellese, A, Palena, A, Turco, A, Cocozza, S, Auciello, S, Cigolini, M, Pichiri, I, Brangani, C, Tomasetto, E, Sinagra, T, Longhitano, S, Tropea, V, Ballardini, G, Babini, A, Ripani, R, Gregori, G, Dolci, M, Bruselli, L, Salutini, I, Mori, M, Baccetti, F, Lapolla, A, Sartore, G, Burlina, S, Chilelli, N, Buzzetti, R, Venditti, C, Carlone, A, Galluzzo, A, Giordano, C, Torregrossa, V, Corsi, L, Cuneo, G, Corsi, S, Tizio, B, Galluzzo, G, Citro, G, Natale, M, Salvatore, V, Di Cianni, G, Lacaria, E, Russo, L, Iannarelli, R, De Gregorio, A, Sciarretta, F, D'Andrea, S, Montani, V, Cannarsa, E, Dolcetti, K, Cordera, R, Bonabello, L, Mazzucchelli, C, Giorda, C, Bonetto, C, Baldassarre, M, Iovine, C, Ciano, O, Dall'Aglio, E, Mancastroppa, G, Grimaldi, F, Tonutti, L, Boemi, M, D'Angelo, F, Leotta, S, Lauro, D, Rinaldi, M, Cignarelli, M, La Macchia, O, Fariello, S, Tomasi, F, Zamboni, C, Dozio, N, Trevisan, R, Scaranna, C, Del Prato, S, Miccoli, R, Garofolo, M, Pugliese, G, Salvi, L, Rangel, G, Anichini, R, Tedeschi, A, Corsini, E, Cucinotta, D, Di Benedetto, A, Giunta, L, Ruffo, M, Bossi, A, Carpinter, R, Dotta, F, Ceccarelli, E, Bartolo, P, Caselli, C, Luberto, A, Calbucci, G, Consoli, A, Ginestra, F, Calabrese, M, Zogheri, A, Laviola, L, Ippolito, C, Tarantino, L, Avogaro, A, Carallo, C, Scicchitano, C, Livraga, S, Perin, P, Forrnengo, P, Prinzis, T, De Cosmo, S, Bacci, S, Lamanna, C, Lettina, G, Aiello, A, Lalli, C, Franzetti, I, Petrachi, F, Asprino, V, Capra, C, Forte, E, Reggiani, G, Forlani, G, Montesi, L, Mazzella, N, Piatti, P, Monti, L, Stuccillo, M, Auletta, P, Petraroli, E, Capobianco, G, Romano, G, Cutolo, M, De Simone, G, Caiazzo, G, Nunziata, P, Sorrentino, S, Amelia, U, Calatola, P, and Capuano, G

Subjects
0301 basic medicine, Male, Age, BMI, Diabetes, Diet, Flavonoids, Food groups, Geographical area, Intake, Phenolic acids, Polyphenols, TOSCA.IT study, Aged, Antioxidants, Beverages, Cinnamates, Cohort Studies, Cross-Sectional Studies, Databases, Factual, Diabetes Mellitus, Type 2, Female, Flavonoids, Fruit, Glycosides, Humans, Italy, Male, Middle Aged, Nutritive Value, Phenols, Polyphenols, Diet, Diabetic, Diet, Healthy, Patient Compliance, Settore MED/09 - Medicina Interna, Databases, Factual, Cross-sectional study, Medicine (miscellaneous), Type 2 diabetes, Diabete, Antioxidants, Settore MED/13 - Endocrinologia, Food group, Cohort Studies, 0302 clinical medicine, Diet, Diabetic, Medicine, Food science, Glycosides, Age, BMI, Diabetes, Diet, Flavonoids, Food groups, Geographical area, Intake, Phenolic acids, Polyphenols, TOSCA.IT study, Nutrition and Dietetics, Phenolic acid, food and beverages, Middle Aged, Polyphenols, Flavonoids, Phenolic acids, Diabetes, Food groups, Diet, Age, BMI, Geographical area, Intake, TOSCA.IT study, Italy, Tosca,Age,BMI,Diabetes,Diet,Flavonoids,Food groups,Geographical area,Intake,Phenolic acids,Polyphenols,TOSCA.IT study, Cohort, Female, Diet, Healthy, Nutritive Value, Cohort study, Polyphenol, 030209 endocrinology & metabolism, Beverages, 03 medical and health sciences, Phenols, Diabetes mellitus, Humans, Aged, 030109 nutrition & dietetics, business.industry, Anthropometry, medicine.disease, Tosca, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Cinnamates, Fruit, Flavonoid, Patient Compliance, business
Abstract

Purpose: Proper evaluation of polyphenols intake at the population level is a necessary step in order to establish possible associations with health outcomes. Available data are limited, and so far no study has been performed in people with diabetes. The aim of this work was to document the intake of polyphenols and their major food sources in a cohort of people with type 2 diabetes and in socio-demographic subgroups. Methods: We studied 2573 men and women aged 50–75 years. Among others, anthropometry was measured by standard protocol and dietary habits were investigated by food frequency questionnaire (EPIC). The intake of polyphenols was evaluated using US Department of Agriculture and Phenol-Explorer databases. Results: The mean total polyphenol intake was 683.3 ± 5.8 mg/day. Non-alcoholic beverages represented the main food source of dietary polyphenols and provided 35.5% of total polyphenol intake, followed by fruits (23.0%), alcoholic beverages (14.0%), vegetables (12.4%), cereal products and tubers (4.6%), legumes (3.7%) and oils (2.1%); chocolate, cakes and nuts are negligible sources of polyphenols in this cohort. The two most important polyphenol classes contributing to the total intake were flavonoids (47.5%) and phenolic acids (47.4%). Polyphenol intake increased with age and education level and decreased with BMI; furthermore, in the northern regions of Italy, the polyphenol intake was slightly, but significantly higher than in the central or southern regions. Conclusions: The study documents for the first time the intake of polyphenols and their main food sources in people with diabetes using validated and complete databases of the polyphenol content of food. Compared with published data, collected in people without diabetes, these results suggest a lower intake and a different pattern of intake in people with diabetes. © 2016 Springer-Verlag Berlin Heidelberg

Published
2016

44. Urine 8-Isoprostane in Relation to Adiposity and Insulin Resistance in Individuals at High Cardiometabolic Risk

Author

Costabile, Giuseppina, primary, Della Pepa, Giuseppe, additional, Bozzetto, Lutgarda, additional, Annuzzi, Giovanni, additional, Vetrani, Claudia, additional, Giacco, Rosalba, additional, Della Corte, Giuseppina, additional, Conte, Francesca Serena, additional, Di Marino, Lucrezia, additional, and Rivellese, Angela Albarosa, additional

Published
2015
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45. Isocaloric Dietary Changes and Non-Alcoholic Fatty Liver Disease in High Cardiometabolic Risk Individuals.

Author

Pepa, Giuseppe Della, Vetrani, Claudia, Lombardi, Gianluca, Bozzetto, Lutgarda, Annuzzi, Giovanni, and Rivellese, Angela Albarosa

Abstract

Non-alcoholic fatty liver disease (NAFLD) incorporates an extensive spectrum of histologic liver abnormalities, varying from simple triglyceride accumulation in hepatocytes non-alcoholic fatty liver (NAFL) to non-alcoholic steatohepatitis (NASH), and it is the most frequent chronic liver disease in the industrialized world. Beyond liver related complications such as cirrhosis and hepatocellular carcinoma, NAFLD is also an emerging risk factor for type 2 diabetes and cardiovascular disease. Currently, lifestyle intervention including strategies to reduce body weight and to increase regular physical activity represents the mainstay of NAFLD management. Total caloric intake plays a very important role in both the development and the treatment of NAFLD; however, apart from the caloric restriction alone, modifying the quality of the diet and modulating either the macro- or micronutrient composition can also markedly affect the clinical evolution of NAFLD, offering a more realistic and feasible treatment alternative. The aim of the present review is to summarize currently available evidence from randomized controlled trials on the effects of different nutrients including carbohydrates, lipids, protein and other dietary components, in isocaloric conditions, on NAFLD in people at high cardiometabolic risk. We also describe the plausible mechanisms by which different dietary components could modulate liver fat content. [ABSTRACT FROM AUTHOR]

Published
2017
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46. Pasta Consumption and Connected Dietary Habits: Associations with Glucose Control, Adiposity Measures, and Cardiovascular Risk Factors in People with Type 2 Diabetes—TOSCA.IT Study.

Author

Vitale, Marilena, Masulli, Maria, Rivellese, Angela Albarosa, Bonora, Enzo, Babini, Anna Carla, Sartore, Giovanni, Corsi, Laura, Buzzetti, Raffaella, Citro, Giuseppe, Baldassarre, Maria Pompea Antonia, Bossi, Antonio Carlo, Giordano, Carla, Auciello, Stefania, Dall'Aglio, Elisabetta, Iannarelli, Rossella, Tonutti, Laura, Sacco, Michele, Di Cianni, Graziano, Clemente, Gennaro, and Gregori, Giovanna

Abstract

Background: Pasta is a refined carbohydrate with a low glycemic index. Whether pasta shares the metabolic advantages of other low glycemic index foods has not really been investigated. The aim of this study is to document, in people with type-2 diabetes, the consumption of pasta, the connected dietary habits, and the association with glucose control, measures of adiposity, and major cardiovascular risk factors. Methods: We studied 2562 participants. The dietary habits were assessed with the European Prospective Investigation into Cancer and Nutrition (EPIC) questionnaire. Sex-specific quartiles of pasta consumption were created in order to explore the study aims. Results: A higher pasta consumption was associated with a lower intake of proteins, total and saturated fat, cholesterol, added sugar, and fiber. Glucose control, body mass index, prevalence of obesity, and visceral obesity were not significantly different across the quartiles of pasta intake. No relation was found with LDL cholesterol and triglycerides, but there was an inverse relation with HDL-cholesterol. Systolic blood pressure increased with pasta consumption; but this relation was not confirmed after correction for confounders. Conclusions: In people with type-2 diabetes, the consumption of pasta, within the limits recommended for total carbohydrates intake, is not associated with worsening of glucose control, measures of adiposity, and major cardiovascular risk factors. [ABSTRACT FROM AUTHOR]

Published
2020
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47. Acute and chronic improvement in postprandial glucose metabolism by a diet resembling the traditional Mediterranean dietary pattern: Can SCFAs play a role?

Author

Dominic Salamone, Anna Mangione, Marilena Vitale, Danilo Ercolini, Giuseppe Della Pepa, Paola Vitaglione, Rosalba Giacco, Manolo Laiola, Angela A. Rivellese, Delia Luongo, Vitale, Marilena, Giacco, Rosalba, Laiola, Manolo, Della Pepa, Giuseppe, Luongo, Delia, Mangione, Anna, Salamone, Dominic, Vitaglione, Paola, Ercolini, Danilo, and Rivellese, Angela Albarosa

Subjects
Adult, Blood Glucose, Male, 0301 basic medicine, Time Factors, Mediterranean diet, medicine.medical_treatment, Physiology, 030209 endocrinology & metabolism, Overweight, Gut flora, Carbohydrate metabolism, Diet, Mediterranean, Critical Care and Intensive Care Medicine, Feces, Young Adult, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Insulin, Obesity, Meals, Meal, 030109 nutrition & dietetics, Nutrition and Dietetics, biology, business.industry, Lipid metabolism, Fasting, Middle Aged, Lipid Metabolism, Postprandial Period, biology.organism_classification, Gastrointestinal Microbiome, Postprandial, Diet, Western, Area Under Curve, Butyric Acid, Female, Insulin Resistance, medicine.symptom, business
Abstract

Postprandial metabolic abnormalities are considered important and independent risk factors for cardiovascular diseases. However, the effects of the Mediterranean diet on postprandial metabolism and the mechanism underpinning the effects on clinical variables have not been exhaustively explored. Therefore, the aims of the present study were to evaluate the acute and medium-term effects (8 weeks) on postprandial glucose and lipid metabolism of a diet resembling a typical Mediterranean diet (Med-D) compared to a western-type diet (Control-D), and the mechanisms underlying those effects.Twenty-nine overweight/obese individuals of both genders, aged 20-60 years, were enrolled and randomly assigned to two isoenergetic dietary interventions: 1) a Med-D (n = 16), and 2) a Control-D (n = 13). Adherence to the dietary interventions was assessed by a 7-day food record. A meal test resembling the assigned diet was performed at baseline and after 8 weeks of intervention. Blood samples at fasting and over 4-h after the meal were collected to assess metabolic parameters and short chain fatty acid (SCFA) levels. Fecal samples were also collected to evaluate the microbiota composition.Glucose and insulin responses were significantly reduced at baseline after the Med test meal compared to the Control meal (p 0.05) and this effect was strengthened after 8 weeks of intervention with the Mediterranean diet (p 0.05); together with an improvement in OGIS. At the end of the intervention, postprandial plasma butyric acid incremental area under the curve (IAUC) was significantly increased in the Med-D group (p = 0.019) and correlated inversely with plasma insulin IAUC and directly with oral glucose insulin sensitivity (OGIS) (r: -0.411, p = 0.046 and r: 0.397, p = 0.050 respectively). These metabolic changes were accompanied by significant changes in gut microbiota, such as an increase in the relative abundance of Intestinimonas butyriciproducens and Akkermansia muciniphila (p 0.05) in the Med-D compared to Control-D group.Our study provides strong evidence that a diet resembling the traditional Med-D improves postprandial glucose metabolism and insulin sensitivity. Furthermore, the study highlights a possible involvement of gut microbiota metabolites - such as butyric acid, and of dietary fiber as a precursor - in improving glucose metabolism and insulin sensitivity.

Published
2021

48. Reduction of De Novo Lipogenesis Mediates Beneficial Effects of Isoenergetic Diets on Fatty Liver: Mechanistic Insights from the MEDEA Randomized Clinical Trial

Author

Giuseppina Costabile, Giuseppe Della Pepa, Dominic Salamone, Delia Luongo, Daniele Naviglio, Valentina Brancato, Carlo Cavaliere, Marco Salvatore, Paola Cipriano, Marilena Vitale, Alessandra Corrado, Angela Rivellese, Giovanni Annuzzi, Lutgarda Bozzetto, Costabile, Giuseppina, DELLA PEPA, Giuseppe, Salamone, Dominic, Luongo, Delia, Naviglio, Daniele, Brancato, Valentina, Cavaliere, Carlo, Salvatore, Marco, Cipriano, Paola, Vitale, Marilena, Corrado, Alessandra, Rivellese, ANGELA ALBAROSA, Annuzzi, Giovanni, and Bozzetto, Lutgarda

Subjects
Polyphenol, de novo lipogenesi, Nutrition and Dietetics, 3-Hydroxybutyric Acid, Lipogenesis, Lipogenesi, Palmitic Acid, Polyphenols, food and beverages, fatty liver, de novo lipogenesis, SCD1, β-hydroxybutyrate, polyphenols, MUFA, β‐hydroxybutyrate, Diet, Diabetes Mellitus, Type 2, Non-alcoholic Fatty Liver Disease, Humans, lipids (amino acids, peptides, and proteins), Stearoyl-CoA Desaturase, Human, Food Science
Abstract

Background: Non-alcoholic liver steatosis (NAS) results from an imbalance between hepatic lipid storage, disposal, and partitioning. A multifactorial diet high in fiber, monounsaturated fatty acids (MUFAs), n-6 and n-3 polyunsaturated fatty acids (PUFAs), polyphenols, and vitamins D, E, and C reduces NAS in people with type 2 diabetes (T2D) by 40% compared to a MUFA-rich diet. We evaluated whether dietary effects on NAS are mediated by changes in hepatic de novo lipogenesis (DNL), stearoyl-CoA desaturase (SCD1) activity, and/or β-oxidation. Methods: According to a randomized parallel group study design, 37 individuals with T2D completed an 8-week isocaloric intervention with a MUFA diet (n = 20) or multifactorial diet (n = 17). Before and after the intervention, liver fat content was evaluated by proton magnetic resonance spectroscopy, serum triglyceride fatty acid concentrations measured by gas chromatography, plasma β-hydroxybutyrate by enzymatic method, and DNL and SCD-1 activity assessed by calculating the palmitic acid/linoleic acid (C16:0/C18:2 n6) and palmitoleic acid/palmitic acid (C16:1/C16:0) ratios, respectively. Results: Compared to baseline, mean ± SD DNL significantly decreased after the multifactorial diet (2.2 ± 0.8 vs. 1.5 ± 0.5, p = 0.0001) but did not change after the MUFA diet (1.9 ± 1.1 vs. 1.9 ± 0.9, p = 0.949), with a significant difference between the two interventions (p = 0.004). The mean SCD-1 activity also decreased after the multifactorial diet (0.13 ± 0.05 vs. 0.10 ± 0.03; p = 0.001), but with no significant difference between interventions (p = 0.205). Fasting plasma β-hydroxybutyrate concentrations did not change significantly after the MUFA or multifactorial diet. Changes in the DNL index significantly and positively correlated with changes in liver fat (r = 0.426; p = 0.009). Conclusions: A diet rich in multiple beneficial dietary components (fiber, polyphenols, MUFAs, PUFAs, and other antioxidants) compared to a diet rich only in MUFAs further reduces liver fat accumulation through the inhibition of DNL. Registered under ClinicalTrials.gov no. NCT03380416.

Published
2022
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49. Evaluation of a Whole-Liver Dixon-Based MRI Approach for Quantification of Liver Fat in Patients with Type 2 Diabetes Treated with Two Isocaloric Different Diets

Author

Valentina Brancato, Giuseppe Della Pepa, Lutgarda Bozzetto, Marilena Vitale, Giovanni Annuzzi, Luca Basso, Carlo Cavaliere, Marco Salvatore, Angela Albarosa Rivellese, Serena Monti, Brancato, Valentina, Della Pepa, Giuseppe, Bozzetto, Lutgarda, Vitale, Marilena, Annuzzi, Giovanni, Basso, Luca, Cavaliere, Carlo, Salvatore, Marco, Rivellese, Angela Albarosa, and Monti, Serena

Subjects
hepatic fat fraction, Dixon MRI, type 2 diabetes, magnetic resonance spectroscopy, Clinical Biochemistry
Abstract

Dixon-based methods for the detection of fatty liver have the advantage of being non-invasive, easy to perform and analyze, and to provide a whole-liver coverage during the acquisition. The aim of the study was to assess the feasibility of a whole-liver Dixon-based approach for liver fat quantification in type 2 diabetes (T2D) patients who underwent two different isocaloric dietary treatments: a diet rich in monosaturated fatty acids (MUFA) and a multifactorial diet. Thirty-nine T2D patients were randomly assigned to MUFA diet (n = 21) and multifactorial diet (n = 18). The mean values of the proton density fat fraction (PDFF) over the whole liver and over the ROI corresponding to that chosen for MRS were compared to MRS-PDFF using Spearman’s correlation (ρ). Before–after changes in percentage of liver volume corresponding to MRI-PDFF above thresholds associated with hepatic steatosis (LV%TH, with TH = 5.56%, 7.97% and 8.8%) were considered to assess the proposed approach and compared between diets using Wilcoxon rank-sum test. Statistical significance set at p < 0.05. A strong linear relationship was found between MRS-PDFF and MRI-PDFFs (ρ = 0.85, p < 0.0001). Changes in LV%TH% were significantly higher (p < 0.05) in the multifactorial diet than in MUFA diet (25% vs. 9%, 35% vs. 12%, and 38% vs. 13% decrease, respectively, for TH = 5.56%, 7.97%, and 8.8%) and this was reproducible compared to results obtained using the standard liver fat analysis. A volumetric approach based on Dixon method could be an effective, non-invasive technique that could be used for the quantitative analysis of hepatic steatosis in T2D patients.

Published
2022

50. Fruitarian Diet and Blood Glucose Control in Type 1 Diabetes: A Case Report

Author

Claudia Vetrani, Lutgarda Bozzetto, Giuseppe Della Pepa, Angela Albarosa Rivellese, Giovanni Annuzzi, Vetrani, Claudia, Bozzetto, Lutgarda, Della Pepa, Giuseppe, Rivellese, Angela Albarosa, and Annuzzi, Giovanni

Subjects
glucose control, Nutrition and Dietetics, type 1 diabetes, Endocrinology, Diabetes and Metabolism, insulin pump, fruitarian diet, continuous glucose monitoring, eating habit, Food Science
Abstract

Diet is a key determinant of blood glucose control in individuals with type 1 diabetes. Although dietary education is part of their clinical follow-up, many patients show a propensity to self-treatment, adopting dietary changes, often extreme, that do not consider the overall impact on health. Here, we describe the case of a patient with type 1 diabetes who switched to a fruitarian diet because of ideological beliefs. A 25-year-old man with type 1 diabetes on an insulin pump and continuous glucose monitoring on optimal blood glucose control (HbA1c 6.5%, 48 mmol/mol; glucose time-in-range 70–180 mg/dl, TIR, 90%; coefficient of variation, CV, 36%) switched to a fruitarian diet because of ideological beliefs. After 3 months on this diet, blood glucose control was still optimal (TIR 88%, CV 33%), while plasma triglycerides and liver enzymes were above normal values. After 3 more months, blood glucose control had worsened (TIR 72%, CV 37%), plasma triglyceride and liver enzymes were within normal values, and hyperkalemia was detected. In this case report, a strict fruitarian diet was associated with early negative changes in some biochemical parameters, also in presence of optimal blood glucose control. Dietary counseling remains essential in the follow-up of patients with type 1 diabetes to ensure personalized medical nutrition therapy and monitor dietary changes that may affect health but with no major impact on blood glucose control.

Published
2022

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