225 results on '"Richard MC"'
Search Results
2. Some Ontological and Epistemological Consequences of the Development of Online Family Therapy and What This Could Mean for Practice
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Frank Burbach and Richard Mc Kenny
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Sociology and Political Science ,Psychology (miscellaneous) - Published
- 2022
3. ‘More collaborative and open’: As systemic psychotherapists become more familiar with videoconferencing, are the advantages of the medium becoming more apparent? A focus group study with UK systemic practitioners
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Frank R. Burbach, Katie M. Stiles, Katherine Brown, Victoria M. E. Allen, and Richard Mc Kenny
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Three semi-structured online focus group interviews were conducted with 17 systemic psychotherapists in the UK 1 year after the transition to videoconferencing therapy (or ‘teletherapy’) prompted by the COVID-19 pandemic. Thematic analysis identified 23 themes within 10 superordinate themes including Advantages of working online; Changes to the therapeutic relationship; Comparison to in-person therapy; Using therapeutic techniques online; Disadvantages of working online; Adapting to the affordances and constraints of technology. Whilst experiences were mildly positive overall, participants responded with almost twice as many positive comments as negative ones and described themselves as likely to continue working online. This study explores the advantages of online delivery which were described in the focus groups and posits that these digital affordances will lead to the development of more collaborative and invitational approaches.
- Published
- 2022
4. Deconstructing Mason’s (un)safe (un)certainty
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Richard Mc Kenny
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media_common.quotation_subject ,Philosophy ,Certainty ,Law and economics ,media_common - Abstract
Barry Manson’s safe uncertainty framework has had a significant influence on the fields of systemic psychotherapy and systemic social work. His original 1993 paper has been cited more than 300 times, and a range of interpretations offered and applications proffered. I offer a deconstructive reading of Mason’s 1993 paper, in order to better understand this phenomenon. I focus on issues of style, rhetoric, expositional emphasis, and word choice – why does Mason choose ‘safe’ rather than ‘secure’? Using analysis by Boholm and colleagues, I set out the semantic pros and cons of using ‘safe’ and ‘secure,’ arguing that, on balance, ‘secure’ is the more appropriate word for Mason’s purposes. I then explore Mason’s reporting of practice, in particular the shift over time from indirect to direct reporting of speech. I argue this shift underpins efforts by Mason to clarify his use of safe uncertainty. Mason’s changing use of voice strongly supports the claim that his framework should not be applied to the analysis of, or responses to safeguarding, risk and protection dilemmas, for which more appropriate frameworks are available.
- Published
- 2021
5. ‘Living in a Zoom world’: Survey mapping how COVID‐19 is changing family therapy practice in the UK
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Emily Galloghly, Richard Mc Kenny, Frank Burbach, and Catherine M Porter
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Family therapy ,Original Paper ,Medical education ,Systemic therapy ,teletherapy ,Social Psychology ,Emerging technologies ,coronavirus ,family therapy training ,Sample (statistics) ,Original Papers ,Therapeutic relationship ,Clinical Psychology ,family therapy practice ,COVID‐19 ,Respondent ,Pandemic ,online therapy training ,World Values Survey ,telemental health ,Thematic analysis ,Psychology ,family interventions ,Social Sciences (miscellaneous) - Abstract
Following the COVID-19 pandemic, psychological therapies rapidly moved online in mid-2020. The Association for Family Therapy and Systemic Practice in the UK (AFT) surveyed the attitudes and practices of systemic therapists in the UK in early October 2020, exploring members' views and gathered information about ongoing needs. A sample of 312 people were included in a mixed methods analysis. In total, 65% of respondents felt their overall experience of using online video technology professionally was positive, further reflected in responses to two open-ended questions. Detailed thematic analysis revealed that many positive comments were related to the practical advantages of online working, whilst many negative comments were related to technique and the therapeutic relationship. Possible respondent biases are discussed, and the implications of this change in practice are explored. It remains to be seen if this marks the beginning of a more permanent shift in our field as we explore the potential of new technologies.The vast majority of UK systemic therapists felt that their experience of online video technology was positive.They noted many practical advantages but also identified many challenges regarding therapeutic techniques and the therapeutic relationship.Therapists developed a range of creative solutions to maximise the therapeutic opportunities of online video.在新冠肺炎大流行之后,心理治疗迅速在2020年中期转到线上。英国家庭治疗和系统实践协会(AFT)于2020年10月初对英国系统治疗师的态度和实践进行了调查,探讨了成员的观点,并收集了有关持续存在的需求的信息。采用混合方法分析了312个样本。65%的受访者认为他们在工作中使用在线视频技术的总体体验是积极的,这进一步反映在对两个开放式问题的回答中。详细的主题分析显示,许多正面评论与线上工作的实际优势有关,而许多负面评论与技术和治疗关系有关。本文讨论了受访者可能存在的偏见,并探讨了实践当中这种变化的含义。在我们探索新技术的潜力时,这是否标志着我们的领域开始了一个更持久的转变,还有待观察。.绝大多数英国系统治疗师认为他们线上视频技术的体验是积极的他们指出了许多实际优势,但也指出了在治疗技术和治疗关系方面的许多挑战治疗师开发了一系列创造性的解决方案,以最大限度地利用线上视频的治疗机会.Después de la pandemia de COVID‐19, las terapias psicológicas se cambiaron rápidamente a formato online a mediados de 2020. La Asociación para la Terapia Familiar y la Práctica Sistémica en el Reino Unido (AFT) encuestó las actitudes y prácticas de los terapeutas sistémicos en el Reino Unido a principios de octubre de 2020, explorando las opiniones de los miembros y recopilado información sobre las necesidades actuales. Se incluyó una muestra de 312 en un análisis de métodos mixtos. El 65% de los encuestados sintió que su experiencia general de uso profesional de la tecnología de video en línea fue positiva, lo que se refleja en las respuestas a dos preguntas abiertas. El análisis temático detallado reveló que muchos comentarios positivos se relacionaban con las ventajas prácticas del trabajo en línea, mientras que muchos comentarios negativos se relacionaban con la técnica y la relación terapéutica. Se discuten los posibles sesgos de los encuestados y se exploran las implicaciones de este cambio en la práctica. Queda por ver si esto marca el comienzo de un cambio más permanente en nuestro campo a medida que exploramos el potencial de las nuevas tecnologías.La gran mayoría de terapeutas sistémicos del Reino Unido consideró que su experiencia con la tecnología de video online fue positivaNotaron muchas ventajas prácticas pero también identificaron muchos desafíos con respecto a las técnicas terapéuticas y la relación terapéuticaLos terapeutas desarrollaron una gama de soluciones creativas para maximizar las oportunidades terapéuticas del video en línea.
- Published
- 2021
6. A comparison between IBEX bone health applied to digital radiographs and dual-energy X-ray absorptiometry at the distal-third and ultra-distal regions of the radius
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Ben Lopez, Robert Meertens, Mike Gundry, Paul Scott, Mr Ben Crone, and Richard McWilliam
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Opportunistic screening ,DXA ,aBMD ,T-score ,Forearm ,Wrist ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Background In an ageing population, low impact fragility fractures are becoming increasingly common. However, fracture risk can be reduced where low bone density can be identified at an early stage. In this study we aim to demonstrate that IBEX Bone Health (IBEX BH) can provide a clinically useful prediction from wrist radiographs of aBMD and T-score at the ultra-distal (UD) and distal-third (DT) regions of the radius. Methods A 261-participant single-centre, non-randomised, prospective, study was carried out to compare a) IBEX BH, a quantitative digital radiography software device, to b) Dual-energy X-ray Absorptiometry (DXA). A total of 257 participants with wrist digital radiograph (DR), forearm DXA pairs were included in the analysis after exclusions. Results The adjusted R2 value for IBEX BH outputs to the radial areal bone mineral density (aBMD) produced by a GE Lunar DXA system for the UD region is 0.87 (99% Confidence Interval (CI) [0.84, 0.89]). The adjusted R2 value for IBEX BH outputs to aBMD for the DT region is 0.88 (99% CI [0.85, 0.90]). The Area Under the Receiver Operating Characteristic curve (AUC) for the forearm T-score ≤ − 2.5 risk prediction model at the UD region is 0.95 (99% CI [0.93, 0.98]). The AUC for the forearm T-score ≤ − 2.5 risk prediction model at the DT region is 0.98 (99% CI [0.97, 0.99]). Conclusion From a DR of the wrist, IBEX BH provides a clinically useful i) estimate of aBMD at the two regions of interest on the radius and ii) risk prediction model of forearm T-score ≤ − 2.5 at the UD and DT regions.
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- 2024
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7. Transcutaneous cervical vagus nerve stimulation enhances second-language vocabulary acquisition while simultaneously mitigating fatigue and promoting focus
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Toshiya Miyatsu, Vanessa Oviedo, Jajaira Reynaga, Valerie P. Karuzis, David Martinez, Polly O’Rourke, Melissa Key, Lindsey McIntire, William Aue, Richard McKinley, Peter Pirolli, and Timothy Broderick
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Medicine ,Science - Abstract
Abstract Transcutaneous vagus nerve stimulation (tVNS) is a promising technique for enhancing cognitive performance and skill acquisition. Yet, its efficacy for enhancing learning rate and long-term retention in an ecologically valid learning environment has not been demonstrated. We conducted two double-blind sham-controlled experiments examining the efficacy of auricular tVNS (taVNS: Experiment (1) and cervical tVNS (tcVNS: Experiment (2), on a 5 day second-language vocabulary acquisition protocol among highly selected career linguists at the US Department of Defense’s premier language school. tcVNS produced accelerated recall performance during training (Day 2–4), benefits of which were maintained across a 24 h retention interval with no stimulation at the final test. Consistent with prior work, tcVNS also produced fatigue-mitigating and focus-promoting effects as measured by the Air Force Research Laboratory Mood Questionnaire. Based on the current and the previous findings supporting tVNS’ efficacy on performance, training enhancement, and fatigue mitigation, we believe tcVNS to be an effective learning acceleration tool that can be utilized at language-teaching and other institutions focused on intensive training of cognitive skills.
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- 2024
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8. Investigation of Unresolved Interface 'Rag Layer' in Athabasca Oil Sand Bitumen In Situ Recovery
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Evgeniya Hristova, Stanislav R. Stoyanov, Richard McFarlane, and Kasra Nikooyeh
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Chemistry ,QD1-999 - Published
- 2024
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9. Evidence of direct and indirect reciprocity in network-structured economic games
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Daniel Redhead, Matthew Gervais, Kotrina Kajokaite, Jeremy Koster, Arlenys Hurtado Manyoma, Danier Hurtado Manyoma, Richard McElreath, and Cody T. Ross
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Psychology ,BF1-990 ,Social Sciences - Abstract
Abstract Formal theoretical models propose that cooperative networks can be maintained when individuals condition behavior on social standing. Here, we empirically examine the predictions of such models of positive and negative indirect reciprocity using a suite of network-structured economic games in four rural Colombian communities (N i n d = 496 individuals, N o b s = 53,876 ratings/transfers). We observe that, at a dyadic-level, individuals have a strong tendency to exploit and punish others in bad standing (e.g., those perceived as selfish), and allocate resources to those in good standing (e.g., those perceived as generous). These dyadic findings scale to a more generalized, community level, where reputations for being generous are associated with receipt of allocations, and reputations for being selfish are associated with receipt of punishment. These empirical results illustrate the roles that both positive and negative reciprocity, and costly punishment, play in sustaining community-wide cooperation networks.
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- 2024
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10. Cost and budgetary impact of the vascular systems of closure versus manual compression for peripheral endovascular procedures
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Yann Gouëffic, Richard Mc Williams, Hannah Burton, and Nathalie Verin
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Surgery ,General Medicine ,Cardiology and Cardiovascular Medicine - Published
- 2022
11. Commentary on Coulter et al. 2019 ‘Attaining Theoretical Coherence Within Relationship-Based Practice in Child and Family Social Work: The Systemic Perspective’
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Richard Mc Kenny
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Health (social science) ,Social work ,0502 economics and business ,05 social sciences ,Perspective (graphical) ,0501 psychology and cognitive sciences ,Coherence (statistics) ,Psychology ,050203 business & management ,Social Sciences (miscellaneous) ,050104 developmental & child psychology ,Cognitive psychology - Abstract
Coulter et al. (2019) argue that there is an urgent need for a theoretically coherent conceptualisation of contemporary relationship-based practice (RBP) models within child and family social work. They propose that a systemic and social constructionist ‘lens’ can provide this coherence. This reply draws attention to one particular difficulty with their argument and makes a partial case for maintaining clear distinctions between models, with distinct nomenclature.
- Published
- 2020
12. A Relational Approach to Work with Couples Where Men Have Been Violent Towards Women: Feminist Dilemmas and Contributions to Social Work Practice
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Rebecca Infanti-Milne, Richard Mc Kenny, and Lee Walton
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- 2022
13. DNA barcoding aids in generating a preliminary checklist of the lichens and allied fungi of Calvert Island, British Columbia: Results from the 2018 Hakai Terrestrial BioBlitz
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Richard McMullin, Andrew Simon, Irwin Brodo, Sara Wickham, Philip Bell-Doyon, Maria Kuzmina, and Brian Starzomski
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biogeography ,Calicioids ,Central Coast Regional D ,Biology (General) ,QH301-705.5 - Abstract
Bioblitzes are a tool for the rapid appraisal of biodiversity and are particularly useful in remote and understudied regions and for understudied taxa. Lichens are an example of an often overlooked group, despite being widespread in virtually all terrestrial ecosystems and having many important ecological functions.We report the lichens and allied fungi collected during the 2018 terrestrial bioblitz conducted on Calvert Island on the Central Coast of British Columbia, Canada. We identified 449 specimens belonging to 189 species in 85 genera, increasing the total number of species known from Calvert Island to 194, and generated Internal Transcribed Spacer (ITS) sequences for 215 specimens from 121 species. Bryoria furcellata, Chaenothecopsis lecanactidis and C. nigripunctata were collected for the first time in British Columbia. We also found Pseudocyphellaria rainierensis, which is listed as Special Concern on the federal Species at Risk Act, and other rarely reported species in British Columbia including Opegrapha sphaerophoricola, Protomicarea limosa, Raesaenenia huuskonenii and Sarea difformis. We demonstrate that DNA barcoding improves the scope and accuracy of expert-led bioblitzes by facilitating the detection of cryptic species and allowing for consistent identification of chemically and morphologically overlapping taxa. Despite the spatial and temporal limitations of our study, the results highlight the value of intact forest ecosystems on the Central Coast of British Columbia for lichen biodiversity, education and conservation.
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- 2024
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14. Developing an Open Dialogue inspired model of systemic social work assessment in a local authority children's social care department
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Martin Clement and Richard Mc Kenny
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Clinical Psychology ,Social Psychology ,Social work ,business.industry ,Local authority ,Social care ,Public relations ,business ,Psychology ,Social Sciences (miscellaneous) - Published
- 2019
15. A qualitative study of a Sporting Memories program in South Australia: belonging, participation, and social connection
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Robert John Laidlaw, Richard McGrath, Saravana Kumar, Caroline Adams, and Carolyn M. Murray
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aged ,psychological wellbeing ,quality of life ,learning ,loneliness ,memory ,Public aspects of medicine ,RA1-1270 - Abstract
BackgroundOlder people can experience health and social challenges such as loneliness, depression, and lack of social connectedness. There is need for programs and approaches that address the growing incidence of social isolation and loneliness for older people. One initiative that aims to address these challenges is the Sporting Memories program. This program was developed in the United Kingdom and licensed to South Australia in 2019. The program is currently delivered across six community locations.MethodsThe aim of this study was to explore participants perspectives of the Sporting Memories program in South Australia. Underpinned by qualitative research, three focus groups were conducted, led by an experienced interviewer. Focus groups occurred at three of the six locations, including a day respite center, assisted living center and a government community center. The data were analyzed thematically by the research team.ResultsThere were 16 participants over 65 years old, including four women and 12 men. Three key themes were developed: “free to talk about anything,” “not feeling left out” and “a chance to share and learn.” Collectively, participants reflected on how they built social connections, felt safe and included and learnt more about each other.ConclusionThe Sporting Memories program provides a group program for older people to come together and develop new friendships. The use of sports as a means of reminiscence was considered relatable for the participants who reported social benefits and plans to keep attending. They valued learning through the program which was enhanced by having a facilitator who was knowledgeable about sport.
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- 2024
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16. Innovative delivery of specialist neurological rehabilitation in virtual beds: 7 years’ experience
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Meenakshi Nayar, Davina Richardson, Richard McKinlay, Ajoy Nair, Sarah Daniels, and Jonathan Hayton
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Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
One of the main priorities of the Integrated Care Systems (ICS) is to expand the number of ‘virtual wards’ and deliver multidisciplinary care for patients closer to home. We present to you the Specialist Neurological Rehabilitation Service (SNRS) which has demonstrated over the last 7 years that intensive neurological rehabilitation can be delivered successfully in the patients’ own homes. A novel commissioning model has been used in partnership with different NHS trusts to provide a unified neurorehabilitation service with both inpatient hospital beds and virtual beds in the patients’ own homes. While patients are on the virtual bed pathway, they remain under the care of the Consultant in Rehabilitation Medicine with support from the Clinical Nurse Specialist and have access to diagnostics/interventions and clinic reviews. The patients get daily intensive MDT therapy input from the skilled community team who provide the same frequency of therapy sessions at home (as they would get in a level 2 inpatient neurorehabilitation unit). This pathway is supporting the earlier discharge of patients from hospital. Additionally, the analysis of data from the virtual bed pathway shows that rehabilitation outcomes in patients’ own homes are similar to those of bedded units for this subset of patients with complex neurological needs. This illustrates that the virtual ward model can be successfully implemented in neurorehabilitation.
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- 2024
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17. Branching pretendinous cord anatomic variant of Dupuytren disease: A case report
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Richard McKinney, Aaron Rubinstein, and Steven Regal
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Orthopedic surgery ,RD701-811 - Abstract
Background: Dupuytren disease is the result of a pathologic proliferation of myofibroblasts leading to the formation of dense nodules and eventually palpable cords over the palmar aspect of the hand. These cords have typical anatomic relationships in the palm and fingers and can distort local anatomy, leading to potential iatrogenic injury during surgical treatment. We report a case of a single pretendinous cord that branches into central cords of two individual fingers. Case report: A 75 year old male presents with painful contractures of the left hand involving the middle and ring fingers. A single pretendinous cord originates at the mid palm along the ring finger metacarpal and branches to the ulnar long finger and radial ring finger. The neurovascular bundles were identified in close proximity to the pathologic tissues but did not form true spiral nerve complexes. Literature review: Classic anatomic relationships for pretendinous, central, and spiral cords are well described in the literature. To our knowledge, this is the first reported case of this branching pattern to separate digits, although other branching patterns to the same digit have been previously described. Clinical relevance: The common and proper digital neurovascular bundles can be put at increased risk of injury in the surgical management of Dupuytren disease, especially in the setting of unexpected anatomic variants. It is paramount that surgeons remain vigilant in the unpredictable setting of these pathologic structures and strict adherence to their careful dissection and resection should be stressed.
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- 2024
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18. Ovarian recurrence risk assessment using machine learning, clinical information, and serum protein levels to predict survival in high grade ovarian cancer
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David P. Mysona, Sharad Purohit, Katherine P. Richardson, Jessa Suhner, Bogna Brzezinska, Bunja Rungruang, Diane Hopkins, Gregory Bearden, Robert Higgins, Marian Johnson, Khaled Bin Satter, Richard McIndoe, and Sharad Ghamande
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Medicine ,Science - Abstract
Abstract In ovarian cancer, there is no current method to accurately predict recurrence after a complete response to chemotherapy. Here, we develop a machine learning risk score using serum proteomics for the prediction of early recurrence of ovarian cancer after initial treatment. The developed risk score was validated in an independent cohort with serum collected prospectively during the remission period. In the discovery cohort, patients scored as low-risk had a median time to recurrence (TTR) that was not reached at 10 years compared to 10.5 months (HR 4.66, p
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- 2023
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19. Introduction – Ireland and Finland, 1860–1930: comparative and transnational histories
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Andrew G. Newby and Richard Mc Mahon
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060104 history ,History ,05 social sciences ,050602 political science & public administration ,0601 history and archaeology ,06 humanities and the arts ,Genealogy ,0506 political science - Published
- 2017
20. Behavioural ‘nudging’ interventions to reduce low-value care for low back pain in the emergency department (NUDG-ED): protocol for a 2×2 factorial, before-after, cluster randomised trial
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Rachelle Buchbinder, Matthew Smith, Ian A Harris, Enrico Coiera, Adrian C Traeger, Chris G Maher, Kirsten Howard, Qiang Li, Jeffrey A Linder, James McAuley, Louise Cullen, Ian Ferguson, Sweekriti Sharma, Elise Tcharkhedian, Janet Harrison, Naren Gunja, Gustavo Machado, Richard McNulty, Mark Salter, Paul M Middleton, Ahilan Parameswaran, Kitty Duong, Andrew Coggins, Zoe Michaleff, Gemma Altinger, Trevor Chan, Karen Tambree, Ajay Varshney, Jeremy Lawrence, Kevin Pile, Richard Cracknell, Kara Goon, Daryn Mitford, Raymond Morgan, James Mallows, Kelly Bivona, Helen Zaouk, Brendon Shapter, Jim Basilakis, Helen Badge, Michael Meller, and Robyn Linder
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Medicine - Abstract
Introduction Opioids and imaging are considered low-value care for most people with low back pain. Yet around one in three people presenting to the emergency department (ED) will receive imaging, and two in three will receive an opioid. NUDG-ED aims to determine the effectiveness of two different behavioural ‘nudge’ interventions on low-value care for ED patients with low back pain.Methods and analysis NUDG-ED is a 2×2 factorial, open-label, before-after, cluster randomised controlled trial. The trial includes 8 ED sites in Sydney, Australia. Participants will be ED clinicians who manage back pain, and patients who are 18 years or over presenting to ED with musculoskeletal back pain. EDs will be randomly assigned to receive (i) patient nudges, (ii) clinician nudges, (iii) both interventions or (iv) no nudge control. The primary outcome will be the proportion of encounters in ED for musculoskeletal back pain where a person received a non-indicated lumbar imaging test, an opioid at discharge or both. We will require 2416 encounters over a 9-month study period (3-month before period and 6-month after period) to detect an absolute difference of 10% in use of low-value care due to either nudge, with 80% power, alpha set at 0.05 and assuming an intra-class correlation coefficient of 0.10, and an intraperiod correlation of 0.09. Patient-reported outcome measures will be collected in a subsample of patients (n≥456) 1 week after their initial ED visit. To estimate effects, we will use a multilevel regression model, with a random effect for cluster and patient, a fixed effect indicating the group assignment of each cluster and a fixed effect of time.Ethics and dissemination This study has ethical approval from Southwestern Sydney Local Health District Human Research Ethics Committee (2023/ETH00472). We will disseminate the results of this trial via media, presenting at conferences and scientific publications.Trial registration number ACTRN12623001000695.
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- 2024
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21. Single cell atlas of human gastric muscle immune cells and macrophage-driven changes in idiopathic gastroparesis
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Lakshmikanth L. Chikkamenahalli, Erik Jessen, Cheryl E. Bernard, W.K. Eddie Ip, Margaret Breen-Lyles, Gianluca Cipriani, Suraj R. Pullapantula, Ying Li, Shefaa AlAsfoor, Laura Wilson, Kenneth L. Koch, Braden Kuo, Robert J. Shulman, Bruno P. Chumpitazi, Travis J. McKenzie, Todd A. Kellogg, James Tonascia, Frank A. Hamilton, Irene Sarosiek, Richard McCallum, Henry P. Parkman, Pankaj J. Pasricha, Thomas L. Abell, Gianrico Farrugia, Surendra Dasari, and Madhusudan Grover
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Gastroenterology ,Immunology ,Transcriptomics ,Science - Abstract
Summary: Gastrointestinal immune cells, particularly muscularis macrophages (MM) interact with the enteric nervous system and influence gastrointestinal motility. Here we determine the human gastric muscle immunome and its changes in patients with idiopathic gastroparesis (IG). Single cell sequencing was performed on 26,000 CD45+ cells obtained from the gastric tissue of 20 subjects. We demonstrate 11 immune cell clusters with T cells being most abundant followed by myeloid cells. The proportions of cells belonging to the 11 clusters were similar between IG and controls. However, 9/11 clusters showed 578-11,429 differentially expressed genes. In IG, MM had decreased expression of tissue-protective and microglial genes and increased the expression of monocyte trafficking and stromal activating genes. Furthermore, in IG, IL12 mediated JAK-STAT signaling involved in the activation of tissue-resident macrophages and Eph-ephrin signaling involved in monocyte chemotaxis were upregulated. Patients with IG had a greater abundance of monocyte-like cells. These data further link immune dysregulation to the pathophysiology of gastroparesis.
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- 2024
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22. Pet owner perspectives, motivators and concerns about veterinary biobanking
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Richard McEnhill, Holly Borghese, and Sarah A. Moore
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biospecimen ,disease model ,veterinary clinical trials ,clinical research ,biobank ,animal ,Veterinary medicine ,SF600-1100 - Abstract
IntroductionVeterinary biobanks store samples for future use and distribute samples to academic researchers and industry entities; however, informed consent provided by owners for pets contributing to biobanks can be complicated by limited understanding of goals, purpose, and logistics of biobanking.MethodsThis survey-based study aimed to gather feedback from pet owners on how they viewed allowing their pet to contribute to a veterinary biobank, with the goal of identifying opportunities to improve education, awareness of veterinary biobanking initiatives, and the consent processes. An electronic survey was distributed to a listserv of 2,119 pet owners and responses were received from 118 respondents (5.6%).ResultsMost respondents (67%) were not familiar with the concept of veterinary biobanking prior to having responded to the survey. Most (89%) were willing to allow their healthy pet to contribute samples to a veterinary biobanking program. Ninety-five percent would allow their sick pet to contribute. Most were neutral about financial incentives as a motivator to participate, although 40% indicated that if their pet’s condition resulted in a decision to humanely euthanize, they would be more likely to contribute to the biobank if the veterinary biobanking program covered the cost of euthanasia. Common concerns included security/confidentiality (36%), that results would not be shared with them (33%) or that samples would be used for other purposes beyond those advertised (22%).DiscussionThese results suggest veterinary biobanking initiatives are well received by owners and most are willing to allow their pets to participate. Respondent concerns represent opportunities for veterinary biobanks to improve messaging and dissemination of results from work they support.
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- 2024
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23. Sourcing high tissue quality brains from deceased wild primates with known socio‐ecology
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Tobias Gräßle, Catherine Crockford, Cornelius Eichner, Cédric Girard‐Buttoz, Carsten Jäger, Evgeniya Kirilina, Ilona Lipp, Ariane Düx, Luke Edwards, Anna Jauch, Kathrin S. Kopp, Michael Paquette, Kerrin Pine, EBC Consortium, Daniel B. M. Haun, Richard McElreath, Alfred Anwander, Philipp Gunz, Markus Morawski, Angela D. Friederici, Nikolaus Weiskopf, Fabian H. Leendertz, and Roman M. Wittig
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brain connectivity ,brain evolution ,brain extraction ,brain microstructure ,field necropsy ,MRI ,Ecology ,QH540-549.5 ,Evolution ,QH359-425 - Abstract
Abstract The selection pressures that drove dramatic encephalisation processes through the mammal lineage remain elusive, as does knowledge of brain structure reorganisation through this process. In particular, considerable structural brain changes are present across the primate lineage, culminating in the complex human brain that allows for unique behaviours such as language and sophisticated tool use. To understand this evolution, a diverse sample set of humans' closest relatives with varying socio‐ecologies is needed. However, current brain banks predominantly curate brains from primates that died in zoological gardens. We try to address this gap by establishing a field pipeline mitigating the challenges associated with brain extractions of wild primates in their natural habitat. The success of our approach is demonstrated by our ability to acquire a novel brain sample of deceased primates with highly variable socio‐ecological exposure and a particular focus on wild chimpanzees. Methods in acquiring brain tissue from wild settings are comprehensively explained, highlighting the feasibility of conducting brain extraction procedures under strict biosafety measures by trained veterinarians in field sites. Brains are assessed at a fine‐structural level via high‐resolution MRI and state‐of‐the‐art histology. Analyses confirm that excellent tissue quality of primate brains sourced in the field can be achieved with a comparable tissue quality of brains acquired from zoo‐living primates. Our field methods are noninvasive, here defined as not harming living animals, and may be applied to other mammal systems than primates. In sum, the field protocol and methodological pipeline validated here pose a major advance for assessing the influence of socio‐ecology on medium to large mammal brains, at both macro‐ and microstructural levels as well as aiding with the functional annotation of brain regions and neuronal pathways via specific behaviour assessments.
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- 2023
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24. Investigations into the Charge Times of Lead–Acid Cells under Different Partial-State-of-Charge Regimes
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Max Parker and Richard McMahon
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partial state of charge ,lead–acid ,BESS ,charge acceptance ,Production of electric energy or power. Powerplants. Central stations ,TK1001-1841 ,Industrial electrochemistry ,TP250-261 - Abstract
Partial state of charge (PSOC) is an important use case for lead–acid batteries. Charging times in lead–acid cells and batteries can be variable, and when used in PSOC operation, the manufacturer’s recommended charge times for single-cycle use are not necessarily applicable. Knowing how long charging will take and what the variability in time required is allows for better planning of operations and algorithm creation for battery energy storage system (BESS) manufacturers. This paper details and demonstrates a procedure for identifying the charging time of cells when different charge throughputs occur prior to reaching full charge. The results showed that the charging time in PSOC operations was highly variable when a charge-factor-controlled full-charge procedure was used. Also noted were that higher voltages for the same state of charge were reached as the number of cycles following reaching full charge increased. None of the regimes tested in this paper caused any significant capacity degradation, which demonstrates that PSOC operations can be performed even on cells not specifically designed for them, provided the correct regime is chosen.
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- 2024
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25. Systematic review of economic evaluations of aromatase inhibitors in estrogen receptor-positive breast cancer: quality evaluation
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Maha F. Althuwaibi, Cristina Fernandez-Garcia, Louise Hayes, Richard McNally, and Diarmuid Coughlan
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Aromatase inhibitors ,Tamoxifen ,Cost-effectiveness ,Systematic review ,Breast cancer ,Quality ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Breast cancer (BC) is a leading cause of premature death in women and the most expensive malignancy to treat. Since the introduction of targeted therapies has resulted in changes to BC therapy practices, health economic evaluations have become more important in this area. Taking generic medications, Aromatase Inhibitors (AIs), as a case study, we conducted a systematic review of the recent economic evaluations of AIs for estrogen receptor-positive breast cancer patients and evaluated the quality of these health economic studies. Objective To systematically review and examine the quality of the available economic studies of AIs in estrogen receptor-positive breast cancer. Methods A literature search was performed using six relevant databases (MEDLINE, Embase, Database of Abstracts of Reviews of Effects, Health Technology Assessment Database, NHS Economic Evaluation Database, and SCOPUS) from January 2010 to July 2021. All economic studies were independently assessed by two reviewers using the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) checklist to evaluate the quality of the economic evaluations. This systematic review is registered in the PROSPERO database. To compare the different currencies used in these studies, all costs were converted to international dollars (2021). Results A total of eight studies were included in the review; six (75%) were performed from the healthcare providers’ perspective. They were conducted in seven different countries, and all were model-based analyses using Markov models. Six (75%) considered both Quality Adjusted Life Years (QALYs) and Life Years (LY) outcomes, and all costs were derived from national databases. When compared to tamoxifen, AIs were generally cost-effective in postmenopausal women. Only half of the studies addressed the increased mortality following adverse events, and none mentioned medication adherence. For the quality assessment, six studies fulfilled 85% of the CHEERS checklist requirements and are deemed good quality. Conclusion AIs are generally considered cost-effective compared to tamoxifen in estrogen receptor-positive breast cancer. The overall quality of the included studies was between high and average but characterizing heterogeneity, and distributional effects should be considered in any future economic evaluation studies of AIs. Studies should include adherence and adverse effects profiles to provide evidence to facilitate decision-making among policymakers.
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- 2023
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26. Brain structure and function: a multidisciplinary pipeline to study hominoid brain evolution
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Angela D. Friederici, Roman M. Wittig, Alfred Anwander, Cornelius Eichner, Tobias Gräßle, Carsten Jäger, Evgeniya Kirilina, Ilona Lipp, Ariane Düx, Luke J. Edwards, Cédric Girard-Buttoz, Anna Jauch, Kathrin S. Kopp, Michael Paquette, Kerrin J. Pine, Steve Unwin, Daniel B. M. Haun, Fabian H. Leendertz, Richard McElreath, Markus Morawski, Philipp Gunz, Nikolaus Weiskopf, Catherine Crockford, EBC Consortium, Daniel Ashoff, Karoline Albig, Bala Amarasekaran, Sam Angedakin, Caroline Asiimwe, Christian Bock, Birgit Blazey, Andreas Bernhard, Jacinta C Beehner, Laurent Bailanda, Raphael Belais, Thore J Bergman, Denny Böttcher, Tatiana Bortolato, Penelope Carlier, Julian Chantrey, Daniela Denk, Tobias Deschner, Dag Encke, Gelardine Escoubas, Malak Ettaj, Pawel Fedurek, Karina Flores, Alejandra Romero Florero, Richard Franke, Angela D Friederici, Cedric Girard-Buttoz, Jorge Gomez Fortun, Eva Gruber-Dujardin, Susan Hambrecht, Florian Hansmann, Jess Hartel, Daniel BM Haun, Michael Henshall, Catherine Hobaiter, Noémie Hofman, Jennifer E Jaffe, Stomy Karhemere, Evgenya Kirilina, Robert Klopfleisch, Tobias Knauf-Witzens, Kathrin Kopp, Bastian Lange, Kevin E Langergraber, Arne Lawrenz, Kevin Lee, Fabian H Leendertz, Illona Lipp, Matyas Liptovszky, Christelle Patricia Lumbu, Patrice Makouloutou Nzassi, Guy Landry Mamboundou Kouima, Kerstin Mätz-Rensing, Zoltan Mezö, Fanny Minesi, Sophie Moittie, Torsten Møller, Dave Morgan, Mathias Müller, Timothy Mugabe, Martin Muller, Karin Olofsson-Sannö, Alain Ondzie, Emily Otali, Simone Pika, Andrea Pizarro, Kamilla Pleh, Sandra Reichler-Danielowski, Jessica Rendel, Martha M Robbins, Konstantin Ruske, Liran Samuni, Crickette Sanz, Jan Schinköthe, André Schüle, Ingo Schwabe, Katarina Schwalm, Anistan Sebastiampillai, Lara Southern, Sheri Speede, Jonas Steiner, Mark F Stidworthy, Martin Surbeck, Claudia A. Szentiks, Tanguy Tanga, Tobias Loubser Theron, Reiner Ulrich, Erica van de Waal, Sue Walker, Gudrun Wibbelt, Navena Widulin, Hermann Will, Roman M Wittig, Kim Wood, Emiliano Zaccarella, and Klaus Zuberbühler
- Subjects
non-human primates ,behavior ,structural MRI ,histology ,hominoid fossil ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
To decipher the evolution of the hominoid brain and its functions, it is essential to conduct comparative studies in primates, including our closest living relatives. However, strong ethical concerns preclude in vivo neuroimaging of great apes. We propose a responsible and multidisciplinary alternative approach that links behavior to brain anatomy in non-human primates from diverse ecological backgrounds. The brains of primates observed in the wild or in captivity are extracted and fixed shortly after natural death, and then studied using advanced MRI neuroimaging and histology to reveal macro- and microstructures. By linking detailed neuroanatomy with observed behavior within and across primate species, our approach provides new perspectives on brain evolution. Combined with endocranial brain imprints extracted from computed tomographic scans of the skulls these data provide a framework for decoding evolutionary changes in hominin fossils. This approach is poised to become a key resource for investigating the evolution and functional differentiation of hominoid brains.
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- 2024
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27. Cortical thickness and grey-matter volume anomaly detection in individual MRI scans: Comparison of two methods
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David Romascano, Michael Rebsamen, Piotr Radojewski, Timo Blattner, Richard McKinley, Roland Wiest, and Christian Rummel
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Normative modeling ,MRI ,Brain morphometry ,Alzheimer’s disease ,Personalized medicine ,Clinical decision support ,Computer applications to medicine. Medical informatics ,R858-859.7 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Over the past decades, morphometric analysis of brain MRI has contributed substantially to the understanding of healthy brain structure, development and aging as well as to improved characterisation of disease related pathologies. Certified commercial tools based on normative modeling of these metrics are meanwhile available for diagnostic purposes, but they are cost intensive and their clinical evaluation is still in its infancy. Here we have compared the performance of “ScanOMetrics”, an open-source research-level tool for detection of statistical anomalies in individual MRI scans, depending on whether it is operated on the output of FreeSurfer or of the deep learning based brain morphometry tool DL + DiReCT. When applied to the public OASIS3 dataset, containing patients with Alzheimer’s disease (AD) and healthy controls (HC), cortical thickness anomalies in patient scans were mainly detected in regions that are known as predilection areas of cortical atrophy in AD, regardless of the software used for extraction of the metrics. By contrast, anomaly detections in HCs were up to twenty-fold reduced and spatially unspecific using both DL + DiReCT and FreeSurfer. Progression of the atrophy pattern with clinical dementia rating (CDR) was clearly observable with both methods. DL + DiReCT provided results in less than 25 min, more than 15 times faster than FreeSurfer. This difference in computation time might be relevant when considering application of this or similar methodology as diagnostic decision support for neuroradiologists.
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- 2024
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28. Acoustic estimates of sperm whale abundance in the Mediterranean Sea as part of the ACCOBAMS Survey Initiative
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Oliver Boisseau, Jonathan Reid, Conor Ryan, Anna Moscrop, Richard McLanaghan, and Simone Panigada
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passive acoustic monitoring ,density estimation ,sperm whale ,Mediterranean Sea ,density surface modelling ,Physeter macrocephalus ,Science ,General. Including nature conservation, geographical distribution ,QH1-199.5 - Abstract
Acoustic surveys for sperm whales (Physeter macrocephalus) were conducted in the Mediterranean Sea in summer 2018 as part of the vessel-based component of the ACCOBAMS Survey Initiative (ASI). Equal-spaced zigzag transects provided uniform coverage of key sperm whale habitats and were surveyed using a towed hydrophone array deployed from a research vessel at speeds of 5-8 knots. A total of 14,039 km of tracklines were surveyed in the western basin, Hellenic Trench and Libyan waters, with an acoustic coverage of 10% realised for sperm whales. During these surveys, 254 individual sperm whales were detected on the trackline, with an additional 66 individuals off-track. Sperm whales were only seen ten times on-track, with an additional 16 off-track sightings. Estimates of slant range to echolocating whales were used to derive density estimates through both design- and model-based distance sampling methodologies. An acoustic availability of 0.912 (sd = 0.036) was derived from via published models. When correcting for availability bias, a design-based abundance estimates of 2,673 individuals (95% CI 1,739-4,105; CV = 0.21) was derived for the surveyed blocks, which incorporated most known sperm whale habitat in the Mediterranean Sea. The equivalent model-based estimate was 2,825 whales (2,053-3,888; CV = 0.16). Over 97% of detected whales were in the western basin, with highest densities in the Algerian and Liguro-Provencal Basins between Algeria and Spain/France. In the eastern basin, detections were sparse and concentrated along the Hellenic Trench. A density surface modelling (DSM) exercise identified location and benthic aspect as being the most instructive covariates for predicting whale abundance. Distance sampling results were used in a power analysis to quantify the survey effort required to identify population trends. In the most extreme scenario modelled (10% per annum decline with decennial surveys), the population could have dropped by 90% before the decline was identified with high statistical power. Increasing the regularity of surveys would allow population trends to be detected more expediently. Mediterranean sperm whales are listed as Endangered on the IUCN’s Red List and the need for urgent conservation measures to reduce injury and mortality remains paramount for this unique sub-population.
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- 2024
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29. Political imprisonment and the Irish, 1912–1921
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Richard Mc Mahon
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History ,Politics ,Irish ,media_common.quotation_subject ,Political science ,language ,Prison ,Criminology ,Imprisonment ,Law ,language.human_language ,media_common - Abstract
The book under review is a rigorous, comprehensive and sustained study which places the prison experience at the centre of revolutionary politics in early twentieth-century Ireland. At the heart of...
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- 2016
30. STAREE-Mind Imaging Study: a randomised placebo-controlled trial of atorvastatin for prevention of cerebrovascular decline and neurodegeneration in older individuals
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Sharon L Naismith, Craig S Anderson, Stephane Heritier, Michael O'Sullivan, Sophia Zoungas, Joanne Ryan, Ian H Harding, Simone Spark, Meng Law, Trevor T-J Chong, Zachary Flanagan, Richard McIntyre, and Gary Egan
- Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Introduction Cerebrovascular disease and neurodegeneration are causes of cognitive decline and dementia, for which primary prevention options are currently lacking. Statins are well-tolerated and widely available medications that potentially have neuroprotective effects. The STAREE-Mind Imaging Study is a randomised, double-blind, placebo-controlled clinical trial that will investigate the impact of atorvastatin on markers of neurovascular health and brain atrophy in a healthy, older population using MRI. This is a nested substudy of the ‘Statins for Reducing Events in the Elderly’ (STAREE) primary prevention trial.Methods Participants aged 70 years or older (n=340) will be randomised to atorvastatin or placebo. Comprehensive brain MRI assessment will be undertaken at baseline and up to 4 years follow-up, including structural, diffusion, perfusion and susceptibility imaging. The primary outcome measures will be change in brain free water fraction (a composite marker of vascular leakage, neuroinflammation and neurodegeneration) and white matter hyperintensity volume (small vessel disease). Secondary outcomes will include change in perivascular space volume (glymphatic drainage), cortical thickness, hippocampal volume, microbleeds and lacunae, prefrontal cerebral perfusion and white matter microstructure.Ethics and dissemination Academic publications from this work will address the current uncertainty regarding the impact of statins on brain structure and vascular integrity. This study will inform the utility of repurposing these well-tolerated, inexpensive and widely available drugs for primary prevention of neurological outcomes in older individuals. Ethics approval was given by Monash University Human Research Ethics Committee, Protocol 12206.Trial registration number ClinicalTrials.gov Identifier: NCT05586750.
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- 2023
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31. Irish Chicagoans, Nationalism, and the Commemoration of Rebellion in 1898
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Richard Mc Mahon
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060104 history ,History ,Irish ,language ,0601 history and archaeology ,06 humanities and the arts ,General Medicine ,Religious studies ,language.human_language ,Nationalism - Published
- 2016
32. Judith Rowbotham, Marianna Muravyeva and David Nash (eds), Shame, Blame and Culpability: Crime and Violence in the Modern State
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Richard Mc Mahon
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Blame ,History ,State (polity) ,media_common.quotation_subject ,Shame ,Sociology ,Criminology ,Law ,media_common ,Culpability - Published
- 2014
33. Serum Proteomic Signatures in Cervical Cancer: Current Status and Future Directions
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Chaston Weaver, Alisha Nam, Caitlin Settle, Madelyn Overton, Maya Giddens, Katherine P. Richardson, Rachael Piver, David P. Mysona, Bunja Rungruang, Sharad Ghamande, Richard McIndoe, and Sharad Purohit
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cervical cancer ,inflammation ,biomarkers ,proteomics ,bioinformatics ,artificial intelligence ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
In 2020, the World Health Organization (WHO) reported 604,000 new diagnoses of cervical cancer (CC) worldwide, and over 300,000 CC-related fatalities. The vast majority of CC cases are caused by persistent human papillomavirus (HPV) infections. HPV-related CC incidence and mortality rates have declined worldwide because of increased HPV vaccination and CC screening with the Papanicolaou test (PAP test). Despite these significant improvements, developing countries face difficulty implementing these programs, while developed nations are challenged with identifying HPV-independent cases. Molecular and proteomic information obtained from blood or tumor samples have a strong potential to provide information on malignancy progression and response to therapy in CC. There is a large amount of published biomarker data related to CC available but the extensive validation required by the FDA approval for clinical use is lacking. The ability of researchers to use the big data obtained from clinical studies and to draw meaningful relationships from these data are two obstacles that must be overcome for implementation into clinical practice. We report on identified multimarker panels of serum proteomic studies in CC for the past 5 years, the potential for modern computational biology efforts, and the utilization of nationwide biobanks to bridge the gap between multivariate protein signature development and the prediction of clinically relevant CC patient outcomes.
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- 2024
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34. Correction to: ‘The natural selection of bad science’ (2016) by Paul E. Smaldino and Richard McElreath
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Paul E. Smaldino and Richard McElreath
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Science - Published
- 2023
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35. Select Document: John Hampden Jackson, ‘Finland and Ireland: assorted comparisons’ (1937)
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Richard Mc Mahon and Andrew G. Newby
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060104 history ,History ,Irish ,05 social sciences ,050602 political science & public administration ,language ,0601 history and archaeology ,06 humanities and the arts ,language.human_language ,Genealogy ,0506 political science - Abstract
This select document is an annotated translation of John Hampden Jackson’s 1937 Finnish-language text ‘Finland and Ireland: assorted comparisons’, an article previously unavailable in English. It represents an intriguing and extended instance of the generalised comparisons that were made between Irish and Finnish history by observers from the nineteenth century onwards. Therefore, as an example of a mid-twentieth-century primer of the two countries’ ‘parallel histories’, Hampden Jackson’s article is an excellent resource. Moreover, although Hampden Jackson had carved out a niche by the 1930s as an expert on Finland, his reflections on Ireland expose a rather patchy and superficial knowledge, and arguably a degree of condescension. Some of the value of translating this article is that it exposes attitudes of the (broadly-defined) British Left towards Ireland in the 1930s, and particularly the way these were presented, in comparisons with other countries, to an overseas audience.
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- 2017
36. Federated learning enables big data for rare cancer boundary detection
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Sarthak Pati, Ujjwal Baid, Brandon Edwards, Micah Sheller, Shih-Han Wang, G. Anthony Reina, Patrick Foley, Alexey Gruzdev, Deepthi Karkada, Christos Davatzikos, Chiharu Sako, Satyam Ghodasara, Michel Bilello, Suyash Mohan, Philipp Vollmuth, Gianluca Brugnara, Chandrakanth J. Preetha, Felix Sahm, Klaus Maier-Hein, Maximilian Zenk, Martin Bendszus, Wolfgang Wick, Evan Calabrese, Jeffrey Rudie, Javier Villanueva-Meyer, Soonmee Cha, Madhura Ingalhalikar, Manali Jadhav, Umang Pandey, Jitender Saini, John Garrett, Matthew Larson, Robert Jeraj, Stuart Currie, Russell Frood, Kavi Fatania, Raymond Y. Huang, Ken Chang, Carmen Balaña Quintero, Jaume Capellades, Josep Puig, Johannes Trenkler, Josef Pichler, Georg Necker, Andreas Haunschmidt, Stephan Meckel, Gaurav Shukla, Spencer Liem, Gregory S. Alexander, Joseph Lombardo, Joshua D. Palmer, Adam E. Flanders, Adam P. Dicker, Haris I. Sair, Craig K. Jones, Archana Venkataraman, Meirui Jiang, Tiffany Y. So, Cheng Chen, Pheng Ann Heng, Qi Dou, Michal Kozubek, Filip Lux, Jan Michálek, Petr Matula, Miloš Keřkovský, Tereza Kopřivová, Marek Dostál, Václav Vybíhal, Michael A. Vogelbaum, J. Ross Mitchell, Joaquim Farinhas, Joseph A. Maldjian, Chandan Ganesh Bangalore Yogananda, Marco C. Pinho, Divya Reddy, James Holcomb, Benjamin C. Wagner, Benjamin M. Ellingson, Timothy F. Cloughesy, Catalina Raymond, Talia Oughourlian, Akifumi Hagiwara, Chencai Wang, Minh-Son To, Sargam Bhardwaj, Chee Chong, Marc Agzarian, Alexandre Xavier Falcão, Samuel B. Martins, Bernardo C. A. Teixeira, Flávia Sprenger, David Menotti, Diego R. Lucio, Pamela LaMontagne, Daniel Marcus, Benedikt Wiestler, Florian Kofler, Ivan Ezhov, Marie Metz, Rajan Jain, Matthew Lee, Yvonne W. Lui, Richard McKinley, Johannes Slotboom, Piotr Radojewski, Raphael Meier, Roland Wiest, Derrick Murcia, Eric Fu, Rourke Haas, John Thompson, David Ryan Ormond, Chaitra Badve, Andrew E. Sloan, Vachan Vadmal, Kristin Waite, Rivka R. Colen, Linmin Pei, Murat Ak, Ashok Srinivasan, J. Rajiv Bapuraj, Arvind Rao, Nicholas Wang, Ota Yoshiaki, Toshio Moritani, Sevcan Turk, Joonsang Lee, Snehal Prabhudesai, Fanny Morón, Jacob Mandel, Konstantinos Kamnitsas, Ben Glocker, Luke V. M. Dixon, Matthew Williams, Peter Zampakis, Vasileios Panagiotopoulos, Panagiotis Tsiganos, Sotiris Alexiou, Ilias Haliassos, Evangelia I. Zacharaki, Konstantinos Moustakas, Christina Kalogeropoulou, Dimitrios M. Kardamakis, Yoon Seong Choi, Seung-Koo Lee, Jong Hee Chang, Sung Soo Ahn, Bing Luo, Laila Poisson, Ning Wen, Pallavi Tiwari, Ruchika Verma, Rohan Bareja, Ipsa Yadav, Jonathan Chen, Neeraj Kumar, Marion Smits, Sebastian R. van der Voort, Ahmed Alafandi, Fatih Incekara, Maarten M. J. Wijnenga, Georgios Kapsas, Renske Gahrmann, Joost W. Schouten, Hendrikus J. Dubbink, Arnaud J. P. E. Vincent, Martin J. van den Bent, Pim J. French, Stefan Klein, Yading Yuan, Sonam Sharma, Tzu-Chi Tseng, Saba Adabi, Simone P. Niclou, Olivier Keunen, Ann-Christin Hau, Martin Vallières, David Fortin, Martin Lepage, Bennett Landman, Karthik Ramadass, Kaiwen Xu, Silky Chotai, Lola B. Chambless, Akshitkumar Mistry, Reid C. Thompson, Yuriy Gusev, Krithika Bhuvaneshwar, Anousheh Sayah, Camelia Bencheqroun, Anas Belouali, Subha Madhavan, Thomas C. Booth, Alysha Chelliah, Marc Modat, Haris Shuaib, Carmen Dragos, Aly Abayazeed, Kenneth Kolodziej, Michael Hill, Ahmed Abbassy, Shady Gamal, Mahmoud Mekhaimar, Mohamed Qayati, Mauricio Reyes, Ji Eun Park, Jihye Yun, Ho Sung Kim, Abhishek Mahajan, Mark Muzi, Sean Benson, Regina G. H. Beets-Tan, Jonas Teuwen, Alejandro Herrera-Trujillo, Maria Trujillo, William Escobar, Ana Abello, Jose Bernal, Jhon Gómez, Joseph Choi, Stephen Baek, Yusung Kim, Heba Ismael, Bryan Allen, John M. Buatti, Aikaterini Kotrotsou, Hongwei Li, Tobias Weiss, Michael Weller, Andrea Bink, Bertrand Pouymayou, Hassan F. Shaykh, Joel Saltz, Prateek Prasanna, Sampurna Shrestha, Kartik M. Mani, David Payne, Tahsin Kurc, Enrique Pelaez, Heydy Franco-Maldonado, Francis Loayza, Sebastian Quevedo, Pamela Guevara, Esteban Torche, Cristobal Mendoza, Franco Vera, Elvis Ríos, Eduardo López, Sergio A. Velastin, Godwin Ogbole, Mayowa Soneye, Dotun Oyekunle, Olubunmi Odafe-Oyibotha, Babatunde Osobu, Mustapha Shu’aibu, Adeleye Dorcas, Farouk Dako, Amber L. Simpson, Mohammad Hamghalam, Jacob J. Peoples, Ricky Hu, Anh Tran, Danielle Cutler, Fabio Y. Moraes, Michael A. Boss, James Gimpel, Deepak Kattil Veettil, Kendall Schmidt, Brian Bialecki, Sailaja Marella, Cynthia Price, Lisa Cimino, Charles Apgar, Prashant Shah, Bjoern Menze, Jill S. Barnholtz-Sloan, Jason Martin, and Spyridon Bakas
- Subjects
Science - Abstract
Federated ML (FL) provides an alternative to train accurate and generalizable ML models, by only sharing numerical model updates. Here, the authors present the largest FL study to-date to generate an automatic tumor boundary detector for glioblastoma.
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- 2022
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37. Inflammatory bowel disease type influences development of elevated liver enzymes
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Yao‐Wen Cheng, Richard McLean, Justin L Sewell, Chiung‐Yu Huang, and Mandana Khalili
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Crohn's disease ,inflammatory bowel disease ,liver disease ,transaminitis ,ulcerative colitis ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Abstract Background and Aim Up to a third of patients with inflammatory bowel disease (IBD) have elevated liver enzymes (ELE). We evaluated the incidence, predictors, and outcomes associated with ELE in a diverse and vulnerable IBD cohort. Methods We retrospectively evaluated 336 IBD patients receiving care at the San Francisco safety net gastroenterology clinics between June 1996 and December 2019. Baseline characteristics were captured at first visit, then patients were followed until last clinic activity or death. Testing and etiology, pattern of ELE defined as transient (
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- 2022
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38. Outcomes of novel 3D-printed fully porous titanium cup and a cemented highly cross-linked polyethylene liner in complex and revision total hip arthroplasty
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Ittai Shichman, Lyndsay Somerville, William B. Lutes, Stephen A. Jones, Richard McCalden, and Ran Schwarzkopf
- Subjects
Complex primary THA ,Revision THA ,Bone loss ,Paprosky ,Aseptic loosening ,Orthopedic surgery ,RD701-811 - Abstract
Abstract Introduction A novel fully porous acetabular titanium shell has been designed to reduce stiffness mismatch between bone and implant and promote osseointegration in complex (cTHA) and revision total hip arthroplasty (rTHA). A highly cross-linked polyethylene (XLPE) liner is cemented within the cup to reduce wear rates and increase survivorship. This study reported the outcomes of an XLPE liner cemented into a novel 3D-printed fully porous cup in cTHA and rTHA. Methods Presented was a multicenter retrospective review of 40 patients (6 cTHA and 34 rTHA) who underwent THA with a fully porous titanium acetabular cup and cemented XLPE liner. Data were collected on demographics, surgical information, outcomes, including osseointegration and migration and implant survivorship. Results On average, patients were 71.42 ± 9.97 years old and obese (BMI: 30.36 ± 6.88 kg/m2) and were followed up for a mean time of 2.21 ± 0.77 years. Six patients underwent cTHA and 34 patients underwent rTHA. The mean hospital length of stay was 5.34 ± 3.34 days. Three (7.5%) 90-day readmissions were noted. Harris Hip Scores improved, on average, from 53.87 ± 12.58 preoperatively to 83.53 ± 12.15 postoperatively (P
- Published
- 2022
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39. Commentary on Coulter et al. 2019 'Attaining Theoretical Coherence Within Relationship-Based Practice in Child and Family Social Work: The Systemic Perspective'.
- Author
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Kenny, Richard Mc
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CHILD welfare ,FAMILY health ,FAMILY services ,SOCIAL services ,PROFESSIONAL practice - Abstract
Coulter et al. (2019) argue that there is an urgent need for a theoretically coherent conceptualisation of contemporary relationship-based practice (RBP) models within child and family social work. They propose that a systemic and social constructionist 'lens' can provide this coherence. This reply draws attention to one particular difficulty with their argument and makes a partial case for maintaining clear distinctions between models, with distinct nomenclature. [ABSTRACT FROM AUTHOR]
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- 2020
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40. A logical analysis of null hypothesis significance testing using popular terminology
- Author
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Richard McNulty
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Logic ,Null hypothesis significance test ,Hypothesis testing ,Statistical inference ,Statistical significance ,Type I error ,Medicine (General) ,R5-920 - Abstract
Abstract Background Null Hypothesis Significance Testing (NHST) has been well criticised over the years yet remains a pillar of statistical inference. Although NHST is well described in terms of statistical models, most textbooks for non-statisticians present the null and alternative hypotheses (H 0 and H A, respectively) in terms of differences between groups such as (μ 1 = μ 2) and (μ 1 ≠ μ 2) and H A is often stated to be the research hypothesis. Here we use propositional calculus to analyse the internal logic of NHST when couched in this popular terminology. The testable H 0 is determined by analysing the scope and limits of the P-value and the test statistic’s probability distribution curve. Results We propose a minimum axiom set NHST in which it is taken as axiomatic that H 0 is rejected if P-value< α. Using the common scenario of the comparison of the means of two sample groups as an example, the testable H 0 is {(μ 1 = μ 2) and [( $$\overline{x}$$ x ¯ 1 ≠ $$\overline{x}$$ x ¯ 2) due to chance alone]}. The H 0 and H A pair should be exhaustive to avoid false dichotomies. This entails that H A is ¬{(μ 1 = μ 2) and [( $$\overline{x}$$ x ¯ 1 ≠ $$\overline{x}$$ x ¯ 2) due to chance alone]}, rather than the research hypothesis (H T). To see the relationship between H A and H T, H A can be rewritten as the disjunction H A: ({(μ 1 = μ 2) ∧ [( $$\overline{x}$$ x ¯ 1 ≠ $$\overline{x}$$ x ¯ 2) not due to chance alone]} ∨ {(μ 1 ≠ μ 2) ∧ [ $$(\overline{x}$$ ( x ¯ 1 ≠ $$\overline{x}$$ x ¯ 2) not due to (μ 1 ≠ μ 2) alone]} ∨ {( μ 1 ≠ μ 2 ) ∧ [( $$\overline{\boldsymbol{x}}$$ x ¯ 1 ≠ $$\overline{\boldsymbol{x}}$$ x ¯ 2 ) due to ( μ 1 ≠ μ 2 ) alone]}). This reveals that H T (the last disjunct in bold) is just one possibility within H A. It is only by adding premises to NHST that H T or other conclusions can be reached. Conclusions Using this popular terminology for NHST, analysis shows that the definitions of H 0 and H A differ from those found in textbooks. In this framework, achieving a statistically significant result only justifies the broad conclusion that the results are not due to chance alone, not that the research hypothesis is true. More transparency is needed concerning the premises added to NHST to rig particular conclusions such as H T. There are also ramifications for the interpretation of Type I and II errors, as well as power, which do not specifically refer to H T as claimed by texts.
- Published
- 2022
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41. Temporal Changes in Cd Sorption and Plant Bioavailability in Compost-Amended Soils
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Shamim Al Mamun, Niklas J. Lehto, Jo Cavanagh, Richard McDowell, Liv Kellermann, and Brett H. Robinson
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Ca(NO3)2-extractable Cd ,incubation ,potato ,organic amendment ,Physical geography ,GB3-5030 ,Chemistry ,QD1-999 - Abstract
The application of Cd-contaminated phosphate fertiliser has enriched concentrations of this non-essential element in many agricultural soils. Consequently, concentrations of the metal in some agricultural products exceed the Maximum Limit in foods. Composts can reduce the transfer of Cd from soil to plants; however, it is unclear how long this beneficial effect endures. We aimed to determine temporal changes of phytoavailable Cd in two market garden soils (an Allophanic Orthic Granular Soil and a Recent Silt Loam). Soils were amended with either municipal green waste compost or sawdust and animal waste compost at a rate of 2.5% w/w under three incubation regimes: at 19 °C, at 30 °C, and at 30 °C with additional N added as urea at 0.6 g urea/kg soil added over 1 year. Each replicate was sampled after 1, 5, 9, 13, 21, 31, and 49 weeks, and phytoavailable Cd was estimated through 0.05 M Ca(NO3)2 extraction. Seed potato (Solanum tuberosum), ‘Nadine’ variety, was grown in the Pukekohe Allophanic Orthic Granular Soil, freshly amended with municipal compost and the same soil aged for one year. The concentration of Cd in all samples was analysed using an ICP-OES (Inductively Coupled Plasma-Optical Emission Spectrometer). The C concentration in the soil—compost mixtures decreased over the year, with the greatest decreases occurring in the soils incubated at 30 °C with added N. Unexpectedly, the concentration of Ca(NO3)2-extractable Cd in the compost-amended soils did not increase over time and in some cases even decreased. This was confirmed through a pot experiment, which showed the Cd concentration in potato was reduced by 50% in both the freshly amended soil and the amended soil aged for one year. Cadmium immobilisation in soils might be due to both the sorption of Cd by organic matter and the occlusion of sorbed Cd by oxy-hydroxides of iron and aluminium. Over 49 weeks, soluble Cd does not increase as organic matter oxidises. The application of municipal compost to soil will reduce both plant Cd solubility and plant Cd uptake for at least one year in the soils tested.
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- 2023
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42. GENT-44. LOWERED H3K27me3 AND DNA HYPOMETHYLATION DEFINE POORLY PROGNOSTIC PEDIATRIC POSTERIOR FOSSA EPENDYMOMAS
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Sriram Venneti, Ari Melnik, Gaspare Larocca, Alexander R. Judkins, Benita Tamrazi, Chao Lu, Jill Bayliss, Mariarita Santi, Peter W. Lewis, Craig B. Thompson, Ashley Margol, Siddhant U. Jain, Arul M. Chinnaiyan, C. D. Allis, Daniel Martinez, Benjamin A. Garcia, Melike Pekmezci, Piali Mukherjee, Chan Chung, Marcin Cieslik, and Richard Mc Eachin
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Genetics ,Cancer Research ,Pathology ,medicine.medical_specialty ,Oncology ,business.industry ,Posterior fossa ,medicine ,Neurology (clinical) ,business ,DNA hypomethylation - Published
- 2016
43. Impact of low versus negative estrogen/progesterone receptor status on clinico-pathologic characteristics and survival outcomes in HER2-negative breast cancer
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Rachel Yoder, Bruce F. Kimler, Joshua M. Staley, Kelsey Schwensen, Yen Y. Wang, Karissa Finke, Anne O’Dea, Lauren Nye, Manana Elia, Gregory Crane, Richard McKittrick, Robert Pluenneke, Sheshadri Madhusudhana, Larry Beck, Anuj Shrestha, Larry Corum, Mark Marsico, Shane R. Stecklein, Andrew K. Godwin, Qamar J. Khan, and Priyanka Sharma
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Triple-negative breast cancer (TNBC) is classically defined by estrogen receptor (ER) and progesterone receptor (PR) immunohistochemistry expression
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- 2022
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44. Abstract 3863: A subset of poorly prognostic pediatric posterior fossa ependymomas exhibit lowered H3K27me3 and DNA hypomethylation and show epigenetic similarities with H3K27M mutant diffuse intrinsic pontine gliomas
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Venneti, Sriram, primary, Bayliss, Jill, additional, Mukherjee, Piali, additional, Lu, Chao, additional, Jain, Siddhant, additional, Chung, Chan, additional, Martinez, Daniel, additional, Sabari, Benjamin, additional, Margol, Ashley, additional, Panwalkar, Pooja, additional, Paroloia, Abhijit, additional, Pekmezci, Melike, additional, Eachin, Richard Mc, additional, Cieslik, Marcin, additional, Tamrazi, Benita, additional, Garcia, Benjamin, additional, Rocca, Gaspare La, additional, Santi, Mariarita, additional, Lewis, Peter, additional, Hawkins, Cynthia, additional, Melnick, Ari, additional, Allis, C David, additional, Thompson, Craig B., additional, Chinnaiyan, Arul, additional, and Judkins, Alexander R., additional
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- 2017
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45. Patient appropriateness for total knee arthroplasty and predicted probability of a good outcome
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Gillian A Hawker, Eric Bohm, James Stewart, Deborah A Marshall, Raj Sharma, Jason Werle, Peter Faris, Linda J Woodhouse, Bheeshma Ravi, Paul Duffy, Shannon Puloski, Kelly Johnston, Greg Abelseth, Raul Kuchinad, Tom Noseworthy, John Donaghy, C Allyson Jones, James Powell, Ian Stanaitis, Michael J Dunbar, Gillian A. Hawker, Deborah A. Marshall, Michael J. Dunbar, C. Allyson Jones, Linda J. Woodhouse, Gordon Arnett, Robert Balyk, Jeffery Bury, John Cinats, Donald Dick, D'Arcy Durand, Lee Ekert, Robert Glasgow, Don Glasgow, Gordon Goplen, Catherine Hui, Ben Herman, Larry Hunka, Hongxing Jiang, William C. Johnson, Frank Kortbeek, Guy Lavoie, Mitch Lavoie, Paul K. Leung, James Mahood, Edward Masson, Richard McLeod, James McMillan, Greg O’Connor, David Otto, Carlo Panaro, Paulose Paul, Gordon Russell, Colleen Weeks, Don Weber, Andrea Woo, Jane Squire Howden, Anne-Marie Adachi, Jessica Beatty, Shakib Rahman, Kelley De Souza, Robert Korley, Michael Monument, Maureen O'Brien, Ed Rendall, Alex Rezansoff, Scott Timmerman, Tanya Reczek, Jeffrey Depew, and Bukky Dada
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Medicine - Abstract
Objectives One-fifth of total knee arthroplasty (TKA) recipients experience a suboptimal outcome. Incorporation of patients’ preferences in TKA assessment may improve outcomes. We determined the discriminant ability of preoperative measures of TKA need, readiness/willingness and expectations for a good TKA outcome.Methods In patients with knee osteoarthritis (OA) undergoing primary TKA, we preoperatively assessed TKA need (Western Ontario-McMaster Universities OA Index (WOMAC) Pain Score and Knee injury and Osteoarthritis Outcome Score (KOOS) function, arthritis coping), health status, readiness (Patient Acceptable Symptom State, depressive symptoms), willingness (definitely yes—yes/no) and expectations (outcomes deemed ‘very important’). A good outcome was defined as symptom improvement (met Outcome Measures in Rheumatology and Osteoarthritis Research Society International (OMERACT–OARSI) responder criteria) and satisfaction with results 1 year post TKA. Using logistic regression, we assessed independent outcome predictors, model discrimination (area under the receiver operating characteristic curve, AUC) and the predicted probability of a good outcome for different need, readiness/willingness and expectations scenarios.Results Of 1,053 TKA recipients (mean age 66.9 years (SD 8.8); 58.6% women), 78.1% achieved a good outcome. With TKA need alone (WOMAC pain subscale, KOOS physical function short-form), model discrimination was good (AUC 0.67, 95% CI 0.63 to 0.71). Inclusion of readiness/willingness, depressive symptoms and expectations regarding kneeling, stair climbing, well-being and performing recreational activities improved discrimination (p=0.01; optimism corrected AUC 0.70, 0.66–0.74). The predicted probability of a good outcome ranged from 44.4% (33.9–55.5) to 92.4% (88.4–95.1) depending on level of TKA need, readiness/willingness, depressive symptoms and surgical expectations.Conclusions Although external validation is required, our findings suggest that incorporation of patients’ TKA readiness, willingness and expectations in TKA decision-making may improve the proportion of recipients that experience a good outcome.
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- 2023
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46. Replication of the natural selection of bad science
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Florian Kohrt, Paul E. Smaldino, Richard McElreath, and Felix Schönbrodt
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agent-based model ,replication ,metascience ,cultural evolution ,incentives ,Science - Abstract
This study reports an independent replication of the findings presented by Smaldino and McElreath (Smaldino, McElreath 2016 R. Soc. Open Sci. 3, 160384 (doi:10.1098/rsos.160384)). The replication was successful with one exception. We find that selection acting on scientist’s propensity for replication frequency caused a brief period of exuberant replication not observed in the original paper due to a coding error. This difference does not, however, change the authors’ original conclusions. We call for more replication studies for simulations as unique contributions to scientific quality assurance.
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- 2023
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47. GENT-44. LOWERED H3K27me3 AND DNA HYPOMETHYLATION DEFINE POORLY PROGNOSTIC PEDIATRIC POSTERIOR FOSSA EPENDYMOMAS
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Venneti, Sriram, primary, Bayliss, Jill, additional, Mukherjee, Piali, additional, Lu, Chao, additional, Jain, Siddhant, additional, Martinez, Daniel, additional, Margol, Ashley, additional, Pekmezci, Melike, additional, Chung, Chan, additional, Eachin, Richard Mc, additional, Cieslik, Marcin, additional, Garcia, Benjamin, additional, Tamrazi, Benita, additional, Larocca, Gaspare, additional, Santi, Mariarita, additional, Lewis, Peter, additional, Melnik, Ari, additional, Allis, C, additional, Thompson, Craig, additional, Chinnaiyan, Arul, additional, and Judkins, Alexander, additional
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- 2016
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48. Expanding the understanding of majority-bias in children’s social learning
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Anne Sibilsky, Heidi Colleran, Richard McElreath, and Daniel B. M. Haun
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Medicine ,Science - Abstract
Abstract Prior experiments with children across seven different societies have indicated U-shaped age patterns in the likelihood of copying majority demonstrations. It is unclear which learning strategies underlie the observed responses that create these patterns. Here we broaden the understanding of children’s learning strategies by: (1) exploring social learning patterns among 6–13-year-olds (n = 270) from ethnolinguistically varied communities in Vanuatu; (2) comparing these data with those reported from other societies (n = 629), and (3) re-analysing our and previous data based on a theoretically plausible set of underlying strategies using Bayesian methods. We find higher rates of social learning in children from Vanuatu, a country with high linguistic and cultural diversity. Furthermore, our results provide statistical evidence for modest U-shaped age patterns for a more clearly delineated majority learning strategy across the current and previously investigated societies, suggesting that the developmental mechanisms structuring majority bias are cross-culturally highly recurrent and hence a fundamental feature of early human social learning.
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- 2022
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49. Sweet tweets! Evaluating a new approach for probability-based sampling of Twitter
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Trent D. Buskirk, Brian P. Blakely, Adam Eck, Richard McGrath, Ravinder Singh, and Youzhi Yu
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Twitter ,Probability sampling ,Tweets ,Social media ,COVID-19 ,Big data ,Computer applications to medicine. Medical informatics ,R858-859.7 - Abstract
Abstract As survey costs continue to rise and response rates decline, researchers are seeking more cost-effective ways to collect, analyze and process social and public opinion data. These issues have created an opportunity and interest in expanding the fit-for-purpose paradigm to include alternate sources such as passively collected sensor data and social media data. However, methods for accessing, sourcing and sampling social media data are just now being developed. In fact, there has been a small but growing body of literature focusing on comparing different Twitter data access methods through either the elaborate firehose or the free Twitter search or streaming APIs. Missing from the literature is a good understanding of how to randomly sample Tweets to produce datasets that are representative of the daily discourse, especially within geographical regions of interest, without requiring a census of all Tweets. This understanding is necessary for producing quality estimates of public opinion from social media sources such as Twitter. To address this gap, we propose and test the Velocity-Based Estimation for Sampling Tweets (VBEST) algorithm for selecting a probability based sample of tweets. We compare the performance of VBEST sample estimates to other methods of accessing Twitter through the Search API on the distribution of total Tweets as well as COVID-19 keyword incidence and frequency and find that the VBEST samples produce consistent and relatively low levels of overall bias compared to common methods of access through the Search API across many experimental conditions.
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- 2022
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50. Abstract 3863: A subset of poorly prognostic pediatric posterior fossa ependymomas exhibit lowered H3K27me3 and DNA hypomethylation and show epigenetic similarities with H3K27M mutant diffuse intrinsic pontine gliomas
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Chan Chung, Marcin Cieslik, Alexander R. Judkins, Jill Bayliss, Benita Tamrazi, Arul M. Chinnaiyan, Peter W. Lewis, Abhijit Paroloia, Pooja Panwalkar, Craig B. Thompson, Ari Melnick, Chao Lu, Benjamin R. Sabari, Siddhant U. Jain, Cynthia Hawkins, Melike Pekmezci, Piali Mukherjee, Ashley Margol, Mariarita Santi, Gaspare La Rocca, Sriram Venneti, C. David Allis, Benjamin A. Garcia, Daniel Martinez, and Richard Mc Eachin
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Cancer Research ,Pathology ,medicine.medical_specialty ,biology ,Mutant ,Cancer ,medicine.disease ,Pathogenesis ,Histone ,Oncology ,DNA methylation ,biology.protein ,medicine ,Biomarker (medicine) ,Epigenetics ,DNA hypomethylation - Abstract
Pediatric posterior fossa ependymomas are poorly understood childhood brain tumors and have no effective treatments. The biology of these tumors is obscure as recent sequencing efforts suggest that they lack recurrent genetic alterations. A subset of these tumors termed PF-A ependymomas exhibits CpG-island hypermethylation implicating epigenetic alterations in their pathogenesis. Through comprehensive analyses of histone modification, we discovered global H3K27me3 reduction in a subset of these tumors. Tumors with lowered H3K27me3 showed many clinical and biologic similarities with PFA-ependymomas. Global reduction in H3K27me3 is likewise observed in pediatric gliomas that bear histone H3K27M mutations termed diffuse intrinsic pontine gliomas (DIPG) that also arise in the posterior fossa of young children. Analyses of ependymomas with reduced H3K27me3 and H3K27M mutant DIPGs showed many similarities in DNA methylation and enrichment of H3K27me3 in many genomic loci important for neuroglial specification. Combined integrative analysis of both tumor types uncovered common epigenetic deregulation of select factors that control radial glial biology and radial glia in the developing posterior fossa showed reduced H3K27me3. Finally, PF ependymomas with lowered H3K27me3 were more invasive radiologically and exhibited poor prognosis in three independent cohorts (P300). These data have clinical implications for biomarker development and to inform epigenetic approaches to treat PF ependymomas. Citation Format: Sriram Venneti, Jill Bayliss, Piali Mukherjee, Chao Lu, Siddhant Jain, Chan Chung, Daniel Martinez, Benjamin Sabari, Ashley Margol, Pooja Panwalkar, Abhijit Paroloia, Melike Pekmezci, Richard Mc Eachin, Marcin Cieslik, Benita Tamrazi, Benjamin Garcia, Gaspare La Rocca, Mariarita Santi, Peter Lewis, Cynthia Hawkins, Ari Melnick, C David Allis, Craig B. Thompson, Arul Chinnaiyan, Alexander R. Judkins. A subset of poorly prognostic pediatric posterior fossa ependymomas exhibit lowered H3K27me3 and DNA hypomethylation and show epigenetic similarities with H3K27M mutant diffuse intrinsic pontine gliomas [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 3863. doi:10.1158/1538-7445.AM2017-3863
- Published
- 2017
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