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1. Cognitive Testing in People at Increased Risk of Dementia Using a Smartphone App: The iVitality Proof-of-Principle Study

Author

Jongstra, Susan, Wijsman, Liselotte Willemijn, Cachucho, Ricardo, Hoevenaar-Blom, Marieke Peternella, Mooijaart, Simon Pieter, and Richard, Edo

Subjects
Information technology, T58.5-58.64, Public aspects of medicine, RA1-1270
Abstract

BackgroundSmartphone-assisted technologies potentially provide the opportunity for large-scale, long-term, repeated monitoring of cognitive functioning at home. ObjectiveThe aim of this proof-of-principle study was to evaluate the feasibility and validity of performing cognitive tests in people at increased risk of dementia using smartphone-based technology during a 6 months follow-up period. MethodsWe used the smartphone-based app iVitality to evaluate five cognitive tests based on conventional neuropsychological tests (Memory-Word, Trail Making, Stroop, Reaction Time, and Letter-N-Back) in healthy adults. Feasibility was tested by studying adherence of all participants to perform smartphone-based cognitive tests. Validity was studied by assessing the correlation between conventional neuropsychological tests and smartphone-based cognitive tests and by studying the effect of repeated testing. ResultsWe included 151 participants (mean age in years=57.3, standard deviation=5.3). Mean adherence to assigned smartphone tests during 6 months was 60% (SD 24.7). There was moderate correlation between the firstly made smartphone-based test and the conventional test for the Stroop test and the Trail Making test with Spearman ρ=.3-.5 (P

Published
2017
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2. Evaluation of the Use of Home Blood Pressure Measurement Using Mobile Phone-Assisted Technology: The iVitality Proof-of-Principle Study

Author

Wijsman, Liselotte W, Richard, Edo, Cachucho, Ricardo, de Craen, Anton JM, Jongstra, Susan, and Mooijaart, Simon P

Subjects
Information technology, T58.5-58.64, Public aspects of medicine, RA1-1270
Abstract

BackgroundMobile phone-assisted technologies provide the opportunity to optimize the feasibility of long-term blood pressure (BP) monitoring at home, with the potential of large-scale data collection. ObjectiveIn this proof-of-principle study, we evaluated the feasibility of home BP monitoring using mobile phone-assisted technology, by investigating (1) the association between study center and home BP measurements; (2) adherence to reminders on the mobile phone to perform home BP measurements; and (3) referrals, treatment consequences and BP reduction after a raised home BP was diagnosed. MethodsWe used iVitality, a research platform that comprises a Website, a mobile phone-based app, and health sensors, to measure BP and several other health characteristics during a 6-month period. BP was measured twice at baseline at the study center. Home BP was measured on 4 days during the first week, and thereafter, at semimonthly or monthly intervals, for which participants received reminders on their mobile phone. In the monthly protocol, measurements were performed during 2 consecutive days. In the semimonthly protocol, BP was measured at 1 day. ResultsWe included 151 participants (mean age [standard deviation] 57.3 [5.3] years). BP measured at the study center was systematically higher when compared with home BP measurements (mean difference systolic BP [standard error] 8.72 [1.08] and diastolic BP 5.81 [0.68] mm Hg, respectively). Correlation of study center and home measurements of BP was high (R=0.72 for systolic BP and 0.72 for diastolic BP, both P

Published
2016
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5. Safety and efficacy of active blood-pressure reduction to the recommended thresholds for intravenous thrombolysis in patients with acute ischaemic stroke in the Netherlands (TRUTH): a prospective, observational, cluster-based, parallel-group study

Author

Zonneveld, Thomas P, Vermeer, Sarah E, van Zwet, Erik W, Groot, Adrien E D, Algra, Ale, Aerden, Leo A M, Alblas, Kees C L, de Beer, Frank, Brouwers, Paul J A M, de Gans, Koen, van Gemert, H Maarten A, van Ginneken, Bart C A M, Grooters, Gerke S, Halkes, Patricia H A, van der Heijden-Montfroy, Tonny A M H G, Jellema, Korné, de Jong, Sonja W, Lövenich-Ciccarello, Harry, van der Meulen, Willem D M, Peters, Edwin W, van der Ree, Taco C, Remmers, Michel J M, Richard, Edo, Rovers, Jörgen M P, Saxena, Ritu, van Schaik, Sander M, Schonewille, Wouter J, Schreuder, Tobien A H C M L, de Schryver, Els L L M, Schuiling, Wouter J, Spaander, Fianne H, van Tuijl, Julia H, Visser, Marieke C, Zinkstok, Sanne M, Zock, Elles, Dippel, Diederik W J, Kappelle, L Jaap, van Oostenbrugge, Robert J, Roos, Yvo B W E M, Vermeij, Frederique H, Wermer, Marieke J H, van der Worp, H Bart, Nederkoorn, Paul J, and Kruyt, Nyika D

Published
2024
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8. Prevention of dementia using mobile phone applications (PRODEMOS): a multinational, randomised, controlled effectiveness–implementation trial

Author

Witvliet, Patrick, Hoitink, Mart, van de Groep, Bram, Liu, Hongmei, Ge, Siqi, He, Mingyue, Li, Cancan, Jian, Xuening, Jiang, Bin, Sun, Haixin, Ru, Xiaojuan, Sun, Dongling, Lian, Tenghong, Zhang, Weijiao, Zhang, Wenjing, Qi, Jing, Li, Jinghui, Guan, Huiying, Luo, Dongmei, Zhang, Weijia, Yue, Hao, Zheng, Zijing, Zeng, Qiang, Yang, Huangdai, Tang, Yanyan, Tao, Tianqi, Song, Yan, Meng, Xiaosheng, Zhu, Sirui, Jia, Dongmei, Li, Mo, Li, Wenjie, Mu, Haiyan, Jiang, Wenjing, Gao, Wenchao, Hu, Yueqing, Wang, Guohua, Xu, Xizhu, Zhang, Yichun, Li, Dong, Zhang, Xiaoyu, Guo, Xiuhua, Ye, Xiaoyan, Wei, Xi, Moll van Charante, Eric P, Hoevenaar-Blom, Marieke P, Song, Manshu, Andrieu, Sandrine, Barnes, Linda, Birck, Cindy, Brooks, Rachael, Coley, Nicola, Eggink, Esmé, Georges, Jean, Hafdi, Melanie, van Gool, Willem A, Handels, Ron, Hou, Haifeng, Lyu, Jihui, Niu, Yixuan, Song, Libin, Wang, Wenzhi, Wang, Youxin, Wimo, Anders, Yu, Yueyi, Zhang, Jinxia, Zhang, Wei, Brayne, Carol, Wang, Wei, and Richard, Edo

Published
2024
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11. Association of anthropometry and weight change with risk of dementia and its major subtypes: A meta‐analysis consisting 2.8 million adults with 57 294 cases of dementia

Author

Lee, Crystal ManYing, Woodward, Mark, Batty, G David, Beiser, Alexa S, Bell, Steven, Berr, Claudine, Bjertness, Espen, Chalmers, John, Clarke, Robert, Dartigues, Jean‐Francois, Davis‐Plourde, Kendra, Debette, Stéphanie, Di Angelantonio, Emanuele, Feart, Catherine, Frikke‐Schmidt, Ruth, Gregson, John, Haan, Mary N, Hassing, Linda B, Hayden, Kathleen M, Hoevenaar‐Blom, Marieke P, Kaprio, Jaakko, Kivimaki, Mika, Lappas, Georgios, Larson, Eric B, LeBlanc, Erin S, Lee, Anne, Lui, Li‐Yung, van Charante, Eric P Moll, Ninomiya, Toshiharu, Nordestgaard, Liv Tybjærg, Ohara, Tomoyuki, Ohkuma, Toshiaki, Palviainen, Teemu, Peres, Karine, Peters, Ruth, Qizilbash, Nawab, Richard, Edo, Rosengren, Annika, Seshadri, Sudha, Shipley, Martin, Singh‐Manoux, Archana, Strand, Bjorn Heine, Gool, Willem A, Vuoksimaa, Eero, Yaffe, Kristine, and Huxley, Rachel R

Subjects
Biomedical and Clinical Sciences, Nutrition and Dietetics, Health Sciences, Neurosciences, Dementia, Acquired Cognitive Impairment, Clinical Research, Nutrition, Neurodegenerative, Rare Diseases, Brain Disorders, Prevention, Aging, Obesity, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), 2.1 Biological and endogenous factors, Aetiology, Neurological, Cardiovascular, Adult, Aged, Anthropometry, Body Mass Index, Body Size, Body Weight, Dementia, Vascular, Female, Humans, Male, Middle Aged, Risk Factors, Thinness, Waist Circumference, Weight Gain, Weight Loss, Medical and Health Sciences, Psychology and Cognitive Sciences, Endocrinology & Metabolism, Biomedical and clinical sciences, Health sciences, Psychology
Abstract

Uncertainty exists regarding the relation of body size and weight change with dementia risk. As populations continue to age and the global obesity epidemic shows no sign of waning, reliable quantification of such associations is important. We examined the relationship of body mass index, waist circumference, and annual percent weight change with risk of dementia and its subtypes by pooling data from 19 prospective cohort studies and four clinical trials using meta-analysis. Compared with body mass index-defined lower-normal weight (18.5-22.4 kg/m2 ), the risk of all-cause dementia was higher among underweight individuals but lower among those with upper-normal (22.5-24.9 kg/m2 ) levels. Obesity was associated with higher risk in vascular dementia. Similarly, relative to the lowest fifth of waist circumference, those in the highest fifth had nonsignificant higher vascular dementia risk. Weight loss was associated with higher all-cause dementia risk relative to weight maintenance. Weight gain was weakly associated with higher vascular dementia risk. The relationship between body size, weight change, and dementia is complex and exhibits non-linear associations depending on dementia subtype under scrutiny. Weight loss was associated with an elevated risk most likely due to reverse causality and/or pathophysiological changes in the brain, although the latter remains speculative.

Published
2020

12. Investigation of antihypertensive class, dementia, and cognitive decline: A meta-analysis.

Author

Peters, Ruth, Yasar, Sevil, Anderson, Craig S, Andrews, Shea, Antikainen, Riitta, Arima, Hisatomi, Beckett, Nigel, Beer, Joanne C, Bertens, Anne Suzanne, Booth, Andrew, van Boxtel, Martin, Brayne, Carol, Brodaty, Henry, Carlson, Michelle C, Chalmers, John, Corrada, Maria, DeKosky, Steven, Derby, Carol, Dixon, Roger A, Forette, Françoise, Ganguli, Mary, van Gool, Willem A, Guaita, Antonio, Hever, Ann M, Hogan, David B, Jagger, Carol, Katz, Mindy, Kawas, Claudia, Kehoe, Patrick G, Keinanen-Kiukaanniemi, Sirkka, Kenny, Rose Ann, Köhler, Sebastian, Kunutsor, Setor K, Laukkanen, Jari, Maxwell, Colleen, McFall, G Peggy, van Middelaar, Tessa, Moll van Charante, Eric P, Ng, Tze-Pin, Peters, Jean, Rawtaer, Iris, Richard, Edo, Rockwood, Kenneth, Rydén, Lina, Sachdev, Perminder S, Skoog, Ingmar, Skoog, Johan, Staessen, Jan A, Stephan, Blossom CM, Sebert, Sylvain, Thijs, Lutgarde, Trompet, Stella, Tully, Phillip J, Tzourio, Christophe, Vaccaro, Roberta, Vaaramo, Eeva, Walsh, Erin, Warwick, Jane, and Anstey, Kaarin J

Subjects
Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Neurodegenerative, Acquired Cognitive Impairment, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Clinical Trials and Supportive Activities, Aging, Brain Disorders, Clinical Research, Cardiovascular, Dementia, Alzheimer's Disease, Prevention, Neurological, Aged, Aged, 80 and over, Antihypertensive Agents, Cognitive Dysfunction, Female, Humans, Hypertension, Male, Middle Aged, Cognitive Sciences, Neurology & Neurosurgery, Clinical sciences
Abstract

ObjectiveHigh blood pressure is one of the main modifiable risk factors for dementia. However, there is conflicting evidence regarding the best antihypertensive class for optimizing cognition. Our objective was to determine whether any particular antihypertensive class was associated with a reduced risk of cognitive decline or dementia using comprehensive meta-analysis including reanalysis of original participant data.MethodsTo identify suitable studies, MEDLINE, Embase, and PsycINFO and preexisting study consortia were searched from inception to December 2017. Authors of prospective longitudinal human studies or trials of antihypertensives were contacted for data sharing and collaboration. Outcome measures were incident dementia or incident cognitive decline (classified using the reliable change index method). Data were separated into mid and late-life (>65 years) and each antihypertensive class was compared to no treatment and to treatment with other antihypertensives. Meta-analysis was used to synthesize data.ResultsOver 50,000 participants from 27 studies were included. Among those aged >65 years, with the exception of diuretics, we found no relationship by class with incident cognitive decline or dementia. Diuretic use was suggestive of benefit in some analyses but results were not consistent across follow-up time, comparator group, and outcome. Limited data precluded meaningful analyses in those ≤65 years of age.ConclusionOur findings, drawn from the current evidence base, support clinical freedom in the selection of antihypertensive regimens to achieve blood pressure goals.Clinical trials registrationThe review was registered with the international prospective register of systematic reviews (PROSPERO), registration number CRD42016045454.

Published
2020

14. Diagnostic Accuracy of the Telephone Interview for Cognitive Status for the Detection of Dementia in Primary Care

Author

Abdulrahman, Herrer, Jansen, Eva, Hoevenaar-Blom, Marieke, van Dalen, Jan Willem, van Wanrooij, Lennard L., van Bussel, Emma, van Gool, Willem A., Richard, Edo, and van Charante, Eric P. Moll

Subjects
Dementia -- Diagnosis, Telemedicine -- Usage, Primary health care -- Methods, Health, Science and technology
Abstract

PURPOSE Cognitive diagnostic work-up in primary care is not always physically feasible, owing to chronic disabilities and/or travel restrictions. The identification of dementia might be facilitated with diagnostic instruments that are time efficient and easy to perform, as well as useful in the remote setting. We assessed whether the Telephone Interview for Cognitive Status (TICS) might be a simple and accurate alternative for remote diagnostic cognitive screening in primary care. METHODS We administered the TICS (range, 0-41) for 810 of 1,473 older people aged 84.5 (SD, 2.4) years. We scrutinized electronic health records for participants with TICS scores [less than or equal to] 30 and for a random sample of participants with TICS scores >30 for a dementia diagnosis using all data from the Prevention of Dementia by Intensive Vascular Care (preDIVA) trial for 8-12 years of follow-up. We used multiple imputation to correct for verification bias. RESULTS Of the 810 participants, 155 (19.1%) had a TICS score [less than or equal to] 30, and 655 (80.9%) had a TICS score >30. Electronic health records yielded 8.4% (13/154) dementia diagnoses for participants with TICS [less than or equal to] 30 vs none with TICS >30. Multiple imputation for TICS >30 yielded a median of 7/655 (1.1%; interquartile range, 5-8) estimated dementia cases. After multiple imputation, the optimal cutoff score was [less than or equal to] 29, with mean sensitivity 65.4%, specificity 87.8%, positive predictive value 11.9%, negative predictive value 99.0%, and area under the curve 77.4% (95% CI, 56.3%-90.0%). CONCLUSIONS In the present older population, the TICS performed well as a diagnostic screening instrument for excluding dementia and might be particularly useful when face-toface diagnostic screening is not feasible in family practice or research settings. The potential reach to large numbers of people at low cost could contribute to more efficient medical management in primary care. Ann Fam Med 2022;20:130-136. https://doi.org/10.1370/afm.2768, INTRODUCTION In recent decades, increasing emphasis has been placed on early intervention in the care and treatment of persons with dementia to help provide more efficient medical management and advanced [...]

Published
2022
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19. Primary stroke prevention worldwide: translating evidence into action

Author

Abanto, Carlos, Abera, Semaw Ferede, Addissie, Adamu, Adebayo, Oluwadamilola, Adeleye, Amos Olufemi, Adilbekov, Yerzhan, Adilbekova, Bibigul, Adoukonou, Thierry Armel, Aguiar de Sousa, Diana, Ajagbe, Temitope, Akhmetzhanova, Zauresh, Akpalu, Albert, Álvarez Ahlgren, Jhon, Ameriso, Sebastián, Andonova, Silva, Awoniyi, Foloruso Emmanuel, Bakhiet, Moiz, Barboza, Miguel, Basri, Hamidon, Bath, Philip, Bello, Olamide, Bereczki, Dániel, Beretta, Simone, Berkowitz, Aaron, Bernabé-Ortiz, Antonio, Bernhardt, Julie, Berzina, Guna, Bisharyan, Mher, Bovet, Pascal, Budincevic, Hrvoje, Cadilhac, Dominique, Caso, Valeria, Chen, Christopher, Chin, Jerome, Chwojnicki, Kamil, Conforto, Adriana, Cruz, Vitor Tedim, D'Amelio, Marco, Danielyan, Kristine, Davis, Stephen, Demarin, Vida, Dempsey, Robert, Dichgans, Martin, Dokova, Klara, Donnan, Geoffrey, Elkind, Mitchell S., Endres, Matthias, Fischer, Urs, Gankpé, Fortuné, Gaye Saavedra, Andrés, Gil, Artyom, Giroud, Maurice, Gnedovskaya, Elena, Hachinski, Vladimir, Hafdi, Melanie, Hamadeh, Randah, Hamzat, T. Kolapo, Hankey, Graeme, Heldner, Mirjam, Ibrahim, Etedal Ahmed, Ibrahim, Norlinah Mohamed, Inoue, Manabu, Jee, Sungju, Jeng, Jiann-Shing, Kalkonde, Yogesh, Kamenova, Saltanat, Karaszewski, Bartosz, Kelly, Peter, Khan, Taskeen, Kiechl, Stefan, Kondybayeva, Aida, Kõrv, Janika, Kravchenko, Michael, Krishnamurthi, Rita V., Kruja, Jera, Lakkhanaloet, Mongkol, Langhorne, Peter, Lavados, Pablo M., Law, Zhe Kang, Lawal, Abisola, Lazo-Porras, Maria, Lebedynets, Dmytro, Lee, Tsong-Hai, Leung, Thomas, Liebeskind, David S., Lindsay, Patrice, López-Jaramillo, Patricio, Lotufo, Paulo Andrade, Machline-Carrion, Julia, Makanjuola, Akintomiwa, Markus, Hugh Stephen, Marquez-Romero, Juan Manuel, Medina, Marco, Medukhanova, Sabina, Mehndiratta, Man Mohan, Merkin, Alexandr, Mirrakhimov, Erkin, Mohl, Stephanie, Moscoso-Porras, Miguel, Müller-Stierlin, Annabel, Murphy, Sean, Musa, Kamarul Imran, Nasreldein, Ahmed, Nogueira, Raul Gomes, Nolte, Christian, Noubiap, Jean Jacques, Novarro-Escudero, Nelson, Ogun, Yomi, Oguntoye, Richard Ayobami, Oraby, Mohammed Ibrahim, Osundina, Morenike, Ovbiagele, Bruce, Orken, Dilek Necioglu, Ozdemir, Atilla Özcan, Ozturk, Serefnur, Paccot, Melanie, Phromjai, Jurairat, Piradov, Piradov, Platz, Thomas, Potpara, Tatjana, Ranta, Annemarei, Rathore, Farooq, Richard, Edo, Sacco, Ralph L., Sahathevan, Ramesh, Santos Carquín, Irving, Saposnik, Gustavo, Sarfo, Fred Stephen, Sharma, Mike, Sheth, Kevin, Shobhana, A., Suwanwela, Nijasri, Svyato, Irina, Sylaja, P.N., Tao, Xuanchen, Thakur, Kiran T., Toni, Danilo, Topcuoglu, Mehmet Akif, Torales, Julio, Towfighi, Amytis, Truelsen, Thomas Clement, Tsiskaridze, Alexander, Tulloch-Reid, Marshall, Useche, Nicolás, Vanacker, Peter, Vassilopoulou, Sophia, Vukorepa, Gorana, Vuletic, Vladimira, Wahab, Kolawole W., Wang, Wenzhi, Wijeratne, Tissa, Wolfe, Charles, Yifru, Yared Mamushet, Yock-Corrales, Adriana, Yonemoto, Naohiro, Yperzeele, Laetitia, Zhang, Puhong, Owolabi, Mayowa O, Thrift, Amanda G, Mahal, Ajay, Ishida, Marie, Martins, Sheila, Johnson, Walter D, Pandian, Jeyaraj, Abd-Allah, Foad, Yaria, Joseph, Phan, Hoang T, Roth, Greg, Gall, Seana L, Beare, Richard, Phan, Thanh G, Mikulik, Robert, Akinyemi, Rufus O, Norrving, Bo, Brainin, Michael, and Feigin, Valery L

Published
2022
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20. General practitioners' views on cardiovascular prevention for ethnic minorities—a qualitative study in the Netherlands.

Author

Apeldoorn, Joshua A N van, Roozekrans, Alet K, Harskamp, Ralf E, Richard, Edo, Agyemang, Charles, and Charante, Eric P Moll van

Subjects
MINORITIES, CONTINUING medical education, HELPLINES, POTENTIAL barrier, TELEPHONES, QUALITATIVE research
Abstract

Objectives While ethnic minorities in Europe are disproportionally affected by cardiovascular disease (CVD), little is known about how general practitioners (GPs) perceive differences in risk or care needs across ethnic minority groups. Therefore, we explored GPs' views on whether ethnicity influences cardiovascular risk, whether a culturally sensitive approach is warranted, on potential barriers in the provision of such care, and to find potential opportunities to improve cardiovascular prevention for these groups. Methods We conducted a qualitative study by interviewing GPs practising in The Netherlands. The interviews were semistructured, audio-recorded, and analysed by 2 researchers using thematic analysis. Results We interviewed 24 Dutch GPs (50% male). GPs' views on the impact of ethnicity on CVD risk varied widely, yet it was generally recognized as a relevant factor in cardiovascular prevention for most minority groups, prompting earlier case-finding of high-risk patients. While GPs were aware of sociocultural differences, they emphasized an individualized approach. Perceived limitations were language barriers and unfamiliarity with sociocultural customs, leading to a need for continuing medical education on culturally sensitive care and reimbursement of telephone interpreting services. Conclusion Dutch GPs have differing views on the role of ethnicity in evaluating and treating cardiovascular risk. Despite these differences, they emphasized the importance of a personalized and culturally sensitive approach during patient consultations and expressed a need for continuing medical education. Additional research on how ethnicity influences CVD risk may strengthen cardiovascular prevention in increasingly diverse primary care populations. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Apathy and depressive symptoms in older people and incident myocardial infarction, stroke, and mortality: a systematic review and meta-analysis of individual participant data

Author

Eurelings, Lisa SM, van Dalen, Jan Willem, Riet, Gerben ter, van Charante, Eric P Moll, Richard, Edo, van Gool, Willem A, Almeida, Osvaldo P, Alexandre, Tiago S, Baune, Bernhard T, Bickel, Horst, Cacciatore, Francesco, Cooper, Cyrus, de Craen, Ton AJM, Degryse, Jean-Marie, Di Bari, Mauro, Duarte, Yeda A, Feng, Liang, Ferrara, Nicola, Flicker, Leon, Gallucci, Maurizio, Guaita, Antonio, Harrison, Stephanie L, Katz, Mindy J, Lebrão, Maria L, Leung, Jason, Lipton, Richard B, Mengoni, Marta, Ng, Tze Pin, Østbye, Truls, Panza, Francesco, Polito, Letizia, Sander, Dirk, Solfrizzi, Vincenzo, Syddall, Holly E, van der Mast, Roos C, Vaes, Bert, Woo, Jean, Yaffe, Kristine, Gao, Sujuan, Ho, Suzanne C, Lindsay, Joan, Sham, Aprille, Reppermund, Simone, and Unverzagt, Frederick W

Subjects
Brain Disorders, Cardiovascular, Aging, Depression, Clinical Research, Behavioral and Social Science, Heart Disease, Stroke, Mental Health, Prevention, Good Health and Well Being, ICARA Study Group, apathy, cardiovascular disease, depression, meta-analysis, myocardial infarction, older people, stroke, Clinical Sciences, Public Health and Health Services
Abstract

Background:Previous findings suggest that apathy symptoms independently of depressive symptoms measured using the Geriatric Depression Scale (GDS) are associated with cardiovascular disease (CVD) in older individuals. Aims:To study whether apathy and depressive symptoms in older people are associated with future CVD, stroke, and mortality using individual patient-data meta-analysis. Methods:Medline, Embase, and PsycInfo databases up to September 3, 2013, were systematically searched without language restrictions. We sought prospective studies with older (mean age ≥65 years) community-dwelling populations in which the GDS was employed and subsequent stroke and/or CVD were recorded to provide individual participant data. Apathy symptoms were defined as the three apathy-related subitems of the GDS, with depressive symptoms the remaining items. We used myocardial infarction (MI), stroke, and all-cause mortality as main outcomes. Analyses were adjusted for age, sex, and MI/stroke history. An adaptation of the Newcastle-Ottawa scale was used to evaluate bias. Hazard ratios were calculated using one-stage random-effect Cox regression models. Results:Of the 52 eligible studies, 21 (40.4%) were included, comprising 47,625 older people (mean age [standard deviation] 74 [7.4] years), over a median follow-up of 8.8 years. Participants with apathy symptoms had a 21% higher risk of MI (95% confidence interval [CI] 1.08-1.36), a 37% higher risk of stroke (95% CI 1.18-1.59), and a 47% higher risk of all-cause mortality (95% CI 1.38-1.56). Participants with depressive symptoms had a comparably higher risk of stroke (HR 1.36, 95% CI 1.18-1.56) and all-cause mortality (HR 1.44, 95% CI 1.35-1.53), but not of MI (HR 1.08, 95% CI 0.91-1.29). Associations for isolated apathy and isolated depressive symptoms were comparable. Sensitivity analyses according to risk of bias yielded similar results. Conclusion:Our findings stress the clinical importance of recognizing apathy independently of depressive symptoms, and could help physicians identify persons at increased risk of vascular disease.

Published
2018

23. Dementie

Author

Richard, Edo, Richard, Edo, editor, Odekerken, Vincent J.J., editor, and de Wit, Marie-Claire Y., editor

Published
2019
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25. Bewusteloosheid

Author

Richard, Edo, Richard, Edo, editor, Odekerken, Vincent J.J., editor, and de Wit, Marie-Claire Y., editor

Published
2019
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32. ExploreASL: An image processing pipeline for multi-center ASL perfusion MRI studies

Author

Mutsaerts, Henk J.M.M., Petr, Jan, Groot, Paul, Vandemaele, Pieter, Ingala, Silvia, Robertson, Andrew D., Václavů, Lena, Groote, Inge, Kuijf, Hugo, Zelaya, Fernando, O’Daly, Owen, Hilal, Saima, Wink, Alle Meije, Kant, Ilse, Caan, Matthan W.A., Morgan, Catherine, de Bresser, Jeroen, Lysvik, Elisabeth, Schrantee, Anouk, Bjørnebekk, Astrid, Clement, Patricia, Shirzadi, Zahra, Kuijer, Joost P.A., Wottschel, Viktor, Anazodo, Udunna C., Pajkrt, Dasja, Richard, Edo, Bokkers, Reinoud P.H., Reneman, Liesbeth, Masellis, Mario, Günther, Matthias, MacIntosh, Bradley J., Achten, Eric, Chappell, Michael A., van Osch, Matthias J.P., Golay, Xavier, Thomas, David L., De Vita, Enrico, Bjørnerud, Atle, Nederveen, Aart, Hendrikse, Jeroen, Asllani, Iris, and Barkhof, Frederik

Published
2020
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35. Year-by-Year Blood Pressure Variability From Midlife to Death and Lifetime Dementia Risk

Author

den Brok, Melina G. H. E., primary, van Dalen, Jan Willem, additional, Marcum, Zachary A., additional, Busschers, Wim B., additional, van Middelaar, Tessa, additional, Hilkens, Nina, additional, Klijn, Catharina J. M., additional, Moll van Charante, Eric P., additional, van Gool, Willem A., additional, Crane, Paul K., additional, Larson, Eric B., additional, and Richard, Edo, additional

Published
2023
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39. Healthy ageing through internet counselling in the elderly (HATICE): a multinational, randomised controlled trial

Author

Richard, Edo, Moll van Charante, Eric P, Hoevenaar-Blom, Marieke P, Coley, Nicola, Barbera, Mariagnese, van der Groep, Abraham, Meiller, Yannick, Mangialasche, Francesca, Beishuizen, Cathrien B, Jongstra, Susan, van Middelaar, Tessa, Van Wanrooij, Lennard L, Ngandu, Tiia, Guillemont, Juliette, Andrieu, Sandrine, Brayne, Carol, Kivipelto, Miia, Soininen, Hilkka, and Van Gool, Willem A

Published
2019
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42. Associations of Subjective Memory Complaints and Simple Memory Task Scores With Future Dementia in the Primary Care Setting

Author

van Wanrooij, Lennard L., Richard, Edo, Jongstra, Susan, van Charante, Eric P. Moll, and van Gool, Willem A.

Subjects
Memory disorders -- Prognosis -- Surveys -- Risk factors -- Diagnosis, Geriatric assessment -- Methods -- Surveys, Dementia -- Risk factors -- Diagnosis -- Prognosis, Health, Science and technology
Abstract

PURPOSE Family physicians need simple yet comprehensive algorithms to discriminate between community-dwelling older persons who are at increased risk of dementia and those who are not. We aimed to investigate associations between incident dementia and responses to a single question regarding subjective memory complaints (SMC) combined with scores on 2 simple memory tests that are easy to use in the primary care setting. METHODS Analyses were based on data from 3,454 community-dwelling older persons who participated in the 6- to 8-year Prevention of Dementia by Intensive Vascular Care (preDIVA) trial, yielding 21,341 person-years of observation. Participants were considered a single cohort. We used Cox models to assess separate and combined associations of SMC, an imperfect score on the Mini-Mental State Examination delayed recall item (MMSE-5), and an imperfect score on the Visual Association Test (VAT) with future dementia. RESULTS Subjective memory complaints alone were associated with future dementia (hazard ratio [HR] = 3.01; 95% CI, 2.31-3.94; P CONCLUSIONS In persons with SMC, the strength of the association between future dementia and an imperfect MMSE-5 score depends substantially on the VAT score. Key words: dementia; neuropsychological tests; memory; cognition; association learning; self report; geriatric assessment; risk assessment; primary health care, INTRODUCTION A timely dementia diagnosis provides both patients and caregivers the opportunity to adapt to functional deterioration and to initiate appropriate care and treatment. (1) Therefore, it is important that [...]

Published
2019
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45. Older Adults' Reasons for Participating in an eHealth Prevention Trial: A Cross-Country, Mixed-Methods Comparison

Author

Kivipelto, Miia, Sindi, Shireen, Solomon, Alina, Andrieu, Sandrine, Coley, Nicola, Soininen, Hilkka, Rosenberg, Anna, Richard, Edo, van Middelaar, Tessa, Hartmann, Tobias, Brayne, Carol, van Gool, Pim, Moll van Charante, Eric, Beishuizen, Cathrien, Jongstra, Susan, van Wanrooij, Lennard, Hoevenaar-Blom, Marieke, Ngandu, Tiia, Barbera, Mariagnese, Mangiasche, Francesca, Guillemont, Juliette, Meiller, Yannick, van de Groep, Bram, Braynefor, Carol, Soulier, Alexandra, Steensma, Jaap, Igier, Valérie, and Eskelinen, Marjo

Published
2019
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46. Adherence to multidomain interventions for dementia prevention: Data from the FINGER and MAPT trials

Author

Richard, Edo, van Gool, Pim, van Charante, Eric Moll, Beishuizen, Cathrien, Jongstra, Susan, van Middelaar, Tessa, van Wanrooij, Lennard, Hoevenaar-Blom, Marieke, Soininen, Hilkka, Ngandu, Tiia, Barbera, Mariagnese, Kivipelto, Miia, Mangiasche, Francesca, Andrieu, Sandrine, Coley, Nicola, Guillemont, Juliette, Meiller, Yannick, van de Groep, Bram, Brayne, Carol, Solomon, Alina, Laatikainen, Tiina, Strandberg, Timo, Tuomilehto, Jaakko, Antikainen, Riitta, Lindström, Jaana, Lehtisalo, Jenni, Havulinna, Satu, Rauramaa, Rainer, Hänninen, Tuomo, Bäckman, Lars, Stigsdotter-Neely, Anna, Jula, Antti, Peltonen, Markku, Levälahti, Esko, Grönholm, Marko, Hemiö, Katri, Vellas, Bruno, Guyonnet, Sophie, Carrié, Isabelle, Brigitte, Lauréane, Faisant, Catherine, Lala, Françoise, Delrieu, Julien, Villars, Hélène, Combrouze, Emeline, Badufle, Carole, Zueras, Audrey, Cantet, Christelle, Morin, Christophe, Van Kan, Gabor Abellan, Dupuy, Charlotte, Rolland, Yves, Caillaud, Céline, Ousset, Pierre-Jean, Fougère, Bertrand, Willis, Sherry, Belleville, Sylvie, Gilbert, Brigitte, Fontaine, Francine, Dartigues, Jean-François, Marcet, Isabelle, Delva, Fleur, Foubert, Alexandra, Cerda, Sandrine, Marie-Noëlle-Cuffi, Costes, Corinne, Rouaud, Olivier, Manckoundia, Patrick, Quipourt, Valérie, Marilier, Sophie, Franon, Evelyne, Bories, Lawrence, Pader, Marie-Laure, Basset, Marie-France, Lapoujade, Bruno, Faure, Valérie, Yung Tong, Michael Li, Malick-Loiseau, Christine, Cazaban-Campistron, Evelyne, Desclaux, Françoise, Blatge, Colette, Dantoine, Thierry, Laubarie-Mouret, Cécile, Saulnier, Isabelle, Clément, Jean-Pierre, Picat, Marie-Agnès, Bernard-Bourzeix, Laurence, Willebois, Stéphanie, Désormais, Iléana, Cardinaud, Noëlle, Bonnefoy, Marc, Livet, Pierre, Rebaudet, Pascale, Gédéon, Claire, Burdet, Catherine, Terracol, Flavien, Pesce, Alain, Roth, Stéphanie, Chaillou, Sylvie, Louchart, Sandrine, Sudres, Kristelle, Lebrun, Nicolas, Barro-Belaygues, Nadège, Touchon, Jacques, Bennys, Karim, Gabelle, Audrey, Romano, Aurélia, Touati, Lynda, Marelli, Cécilia, Pays, Cécile, Robert, Philippe, Le Duff, Franck, Gervais, Claire, Gonfrier, Sébastien, Gasnier, Yannick, Bordes, Serge, Begorre, Danièle, Carpuat, Christian, Khales, Khaled, Lefebvre, Jean-François, El Idrissi, Samira Misbah, Skolil, Pierre, Salles, Jean-Pierre, Dufouil, Carole, Lehéricy, Stéphane, Chupin, Marie, Mangin, Jean-François, Bouhayia, Ali, Allard, Michèle, Ricolfi, Frédéric, Dubois, Dominique, Bonceour Martel, Marie Paule, Cotton, François, Bonafé, Alain, Chanalet, Stéphane, Hugon, Françoise, Bonneville, Fabrice, Cognard, Christophe, Chollet, François, Payoux, Pierre, Voisin, Thierry, Peiffer, Sophie, Hitzel, Anne, Zanca, Michel, Monteil, Jacques, Darcourt, Jacques, Molinier, Laurent, Derumeaux, Hélène, Costa, Nadège, Vincent, Christian, Perret, Bertrand, Vinel, Claire, and Olivier-Abbal, Pascale

Published
2019
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