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Your search keyword '"Raaymakers, B.W."' showing total 167 results
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167 results on '"Raaymakers, B.W."'

5. The transformation of radiation oncology using real-time magnetic resonance guidance: A review

Author

Hall, William A., Paulson, Eric S., van der Heide, Uulke A., Fuller, Clifton D., Raaymakers, B.W., Lagendijk, Jan J.W., Li, X. Allen, Jaffray, David A., Dawson, Laura A., Erickson, Beth, Verheij, Marcel, Harrington, Kevin J., Sahgal, Arjun, Lee, Percy, Parikh, Parag J., Bassetti, Michael F., Robinson, Clifford G., Minsky, Bruce D., Choudhury, Ananya, Tersteeg, Robert J.H.A., and Schultz, Christopher J.

Published
2019
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11. Intrafraction motion tracking for MR-Linac prostate radiotherapy

Author

Lagendijk, J.J.W., Raaymakers, B.W., Boer, J.C.J. de, Voort van Zyp, J.R.N. van der, Muinck Keizer, Daan Maarten de, Lagendijk, J.J.W., Raaymakers, B.W., Boer, J.C.J. de, Voort van Zyp, J.R.N. van der, and Muinck Keizer, Daan Maarten de

Published
2021

19. Dosimetric impact of soft-tissue based intrafraction motion from 3D cine-MR in prostate SBRT

Author

Muinck-Keizer, D.M. de, Kontaxis, C., Kerkmeijer, L.G.W., Voorst-van Zyp, J.R.N. van der, Berg, C.A.T. van den, Raaymakers, B.W., Lagendijk, J.J., Boer, J.C. den, Muinck-Keizer, D.M. de, Kontaxis, C., Kerkmeijer, L.G.W., Voorst-van Zyp, J.R.N. van der, Berg, C.A.T. van den, Raaymakers, B.W., Lagendijk, J.J., and Boer, J.C. den

Abstract

Item does not contain fulltext, To investigate the dosimetric impact of intrafraction translation and rotation motion of the prostate, as extracted from daily acquired post-treatment 3D cine-MR based on soft-tissue contrast, in extremely hypofractionated (SBRT) prostate patients. Accurate dose reconstruction is performed by using a prostate intrafraction motion trace which is obtained with a soft-tissue based rigid registration method on 3D cine-MR dynamics with a temporal resolution of 11 s. The recorded motion of each time-point was applied to the planning CT, resulting in the respective dynamic volume used for dose calculation. For each treatment fraction, the treatment delivery record was generated by proportionally splitting the plan into 11 s intervals based on the delivered monitor units. For each fraction the doses of all partial plan/dynamic volume combinations were calculated and were summed to lead to the motion-affected fraction dose. Finally, for each patient the five fraction doses were summed, yielding the total treatment dose. Both daily and total doses were compared to the original reference dose of the respective patient to assess the impact of the intrafraction motion. Depending on the underlying motion of the prostate, different types of motion-affected dose distributions were observed. The planning target volumes (PTVs) ensured CTV_30 (seminal vesicles) D99% coverage for all patients, CTV_35 (prostate corpus) coverage for 97% of the patients and GTV_50 (local boost) for 83% of the patients when compared against the strict planning target D99% value. The dosimetric impact due to prostate intrafraction motion in extremely hypofractionated treatments was determined. The presented study is an essential step towards establishing the actual delivered dose to the patient during radiotherapy fractions.

Published
2020

25. EP-1624 First clinical experiences with SBRT on the 1.5 T MR-linac for pelvic lymph node oligometastases

Author

Werensteijn-Honingh, A.M., primary, Kroon, P.S., additional, Winkel, D., additional, Aalbers, E.M., additional, Van Asselen, B., additional, Bol, G.H., additional, Brown, K.J., additional, Eppinga, W.S.C., additional, Glitzner, M., additional, Breugel, E.N. De Groot-van, additional, Hackett, S.L., additional, Intven, M., additional, Kok, J.G.M., additional, Kotte, A.N., additional, Lagendijk, J.J.W., additional, Philippens, M.E.P., additional, Tijssen, R.H.N., additional, Wolthaus, J.W.H., additional, Woodings, S.J., additional, Raaymakers, B.W., additional, and Jürgenliemk-Schulz, I.M., additional

Published
2019
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28. Planning feasibility of extremely hypofractionated prostate radiotherapy on a 1.5 T magnetic resonance imaging guided linear accelerator

Author

Hartogh, M.D. den, Boer, H.C. de, Breugel, E.N. de Groot-van, Zijp, J.R., Hes, J., Heide, U.A. van der, Pos, F.J., Haustermans, K., Depuydt, T., Smeenk, R.J., Kunze-Busch, M., Raaymakers, B.W., Kerkmeijer, L.G.W., Hartogh, M.D. den, Boer, H.C. de, Breugel, E.N. de Groot-van, Zijp, J.R., Hes, J., Heide, U.A. van der, Pos, F.J., Haustermans, K., Depuydt, T., Smeenk, R.J., Kunze-Busch, M., Raaymakers, B.W., and Kerkmeijer, L.G.W.

Abstract

Contains fulltext : 208687.pdf (publisher's version ) (Open Access)

Published
2019

29. Soft-tissue prostate intrafraction motion tracking in 3D cine-MR for MR-guided radiotherapy

Author

Keizer, D.M. de Muinck, Kerkmeijer, L.G.W., Maspero, M., Andreychenko, A., Voort van Zyp, J.R.N. van der, Berg, C.A.T. van den, Raaymakers, B.W., Lagendijk, J.J., Boer, J.C. den, Keizer, D.M. de Muinck, Kerkmeijer, L.G.W., Maspero, M., Andreychenko, A., Voort van Zyp, J.R.N. van der, Berg, C.A.T. van den, Raaymakers, B.W., Lagendijk, J.J., and Boer, J.C. den

Abstract

Item does not contain fulltext, To develop a method to automatically determine intrafraction motion of the prostate based on soft tissue contrast on 3D cine-magnetic resonance (MR) images with high spatial and temporal resolution. Twenty-nine patients who underwent prostate stereotactic body radiotherapy (SBRT), with four implanted cylindrical gold fiducial markers (FMs), had cine-MR imaging sessions after each of five weekly fractions. Each cine-MR session consisted of 55 sequentially obtained 3D data sets ('dynamics') and was acquired over an 11 s period, covering a total of 10 min. The prostate was delineated on the first dynamic of every dataset and this delineation was used as the starting position for the soft tissue tracking (SST). Each subsequent dynamic was rigidly aligned to the first dynamic, based on the contrast of the prostate. The obtained translation and rotation describes the intrafraction motion of the prostate. The algorithm was applied to 6270 dynamics over 114 scans of 29 patients and the results were validated by comparing to previously obtained fiducial marker tracking data of the same dataset. Our proposed tracking method was also retro-perspectively applied to cine-MR images acquired during MR-guided radiotherapy of our first prostate patient treated on the MR-Linac. The difference in the 3D translation results between the soft tissue and marker tracking was below 1 mm for 98.2% of the time. The mean translation at 10 min were X: 0.0 [Formula: see text] 0.8 mm, Y: 1.0 [Formula: see text] 1.8 mm and Z: [Formula: see text] mm. The mean rotation results at 10 min were X: [Formula: see text], Y: 0.1 [Formula: see text] 0.6 degrees and Z: 0.0 [Formula: see text] 0.7 degrees . A fast, robust and accurate SST algorithm was developed which obviates the need for FMs during MR-guided prostate radiotherapy. To our knowledge, this is the first data using full 3D cine-MR images for real-time soft tissue prostate tracking, which is validated against previously obtained marker tracking d

Published
2019

30. Adaptive radiotherapy: The Elekta Unity MR-linac concept

Author

Winkel, D., Bol, G.H., Kroon, P.S., Asselen, B. van, Hackett, S.S., Werensteijn-Honingh, A.M., Intven, M.P.W., Eppinga, W.S.C., Tijssen, R.H.N., Kerkmeijer, L.G.W., Boer, H.C. de, Mook, S., Meijer, G.J, Hes, J., Willemsen-Bosman, M., Breugel, E.N. de Groot-van, Jurgenliemk-Schulz, I.M., Raaymakers, B.W., Winkel, D., Bol, G.H., Kroon, P.S., Asselen, B. van, Hackett, S.S., Werensteijn-Honingh, A.M., Intven, M.P.W., Eppinga, W.S.C., Tijssen, R.H.N., Kerkmeijer, L.G.W., Boer, H.C. de, Mook, S., Meijer, G.J, Hes, J., Willemsen-Bosman, M., Breugel, E.N. de Groot-van, Jurgenliemk-Schulz, I.M., and Raaymakers, B.W.

Abstract

Contains fulltext : 215382.pdf (publisher's version ) (Open Access), Background and purpose: The promise of the MR-linac is that one can visualize all anatomical changes during the course of radiotherapy and hence adapt the treatment plan in order to always have the optimal treatment. Yet, there is a trade-off to be made between the time spent for adapting the treatment plan against the dosimetric gain. In this work, the various daily plan adaptation methods will be presented and applied on a variety of tumour sites. The aim is to provide an insight in the behavior of the state-of-the-art 1.5T MRI guided on-line adaptive radiotherapy methods. Materials and methods: To explore the different available plan adaptation workflows and methods, we have simulated online plan adaptation for five cases with varying levels of inter-fraction motion, regions of interest and target sizes: prostate, rectum, esophagus and lymph node oligometastases (single and multiple target). The plans were evaluated based on the clinical dose constraints and the optimization time was measured. Results: The time needed for plan adaptation ranged between 17 and 485s. More advanced plan adaptation methods generally resulted in more plans that met the clinical dose criteria. Violations were often caused by insufficient PTV coverage or, for the multiple lymph node case, a too high dose to OAR in the vicinity of the PTV. With full online replanning it was possible to create plans that met all clinical dose constraints for all cases. Conclusion: Daily full online replanning is the most robust adaptive planning method for Unity. It is feasible for specific sites in clinically acceptable times. Faster methods are available, but before applying these, the specific use cases should be explored dosimetrically.

Published
2019

31. The transformation of radiation oncology using real-time magnetic resonance guidance: A review

Author

Hall, W.A., Paulson, E.S., Heide, U.A. van der, Fuller, C.D., Raaymakers, B.W., Lagendijk, J.J., Li, X.A., Jaffray, D.A., Dawson, L.A., Erickson, B., Verheij, M., Harrington, K.J., Sahgal, A., Lee, P., Parikh, P.J., Bassetti, M.F., Robinson, C.G., Minsky, B.D., Choudhury, A., Tersteeg, R., Schultz, C.J., Hall, W.A., Paulson, E.S., Heide, U.A. van der, Fuller, C.D., Raaymakers, B.W., Lagendijk, J.J., Li, X.A., Jaffray, D.A., Dawson, L.A., Erickson, B., Verheij, M., Harrington, K.J., Sahgal, A., Lee, P., Parikh, P.J., Bassetti, M.F., Robinson, C.G., Minsky, B.D., Choudhury, A., Tersteeg, R., and Schultz, C.J.

Abstract

Item does not contain fulltext, Radiation therapy (RT) is an essential component of effective cancer care and is used across nearly all cancer types. The delivery of RT is becoming more precise through rapid advances in both computing and imaging. The direct integration of magnetic resonance imaging (MRI) with linear accelerators represents an exciting development with the potential to dramatically impact cancer research and treatment. These impacts extend beyond improved imaging and dose deposition. Real-time MRI-guided RT is actively transforming the work flows and capabilities of virtually every aspect of RT. It has the opportunity to change entirely the delivery methods and response assessments of numerous malignancies. This review intends to approach the topic of MRI-based RT guidance from a vendor neutral and international perspective. It also aims to provide an introduction to this topic targeted towards oncologists without a speciality focus in RT. Speciality implications, areas for physician education and research opportunities are identified as they are associated with MRI-guided RT. The uniquely disruptive implications of MRI-guided RT are discussed and placed in context. We further aim to describe and outline important future changes to the speciality of radiation oncology that will occur with MRI-guided RT. The impacts on RT caused by MRI guidance include target identification, RT planning, quality assurance, treatment delivery, training, clinical workflow, tumour response assessment and treatment scheduling. In addition, entirely novel research areas that may be enabled by MRI guidance are identified for future investigation.

Published
2019

37. PV-0140: Beam characterization of the Elekta MRI-linac for the first clinical trial

Author

Woodings, S., primary, Bluemink, J.J., additional, De Vries, J.H.W., additional, Niatsetski, Y., additional, Van Veelen, B., additional, Schillings, J., additional, Kok, J.G.M., additional, Wolthaus, J.W.H., additional, Hackett, S.L., additional, Van Asselen, B., additional, Van Zijp, H.M., additional, Pencea, S., additional, Roberts, D.A., additional, Lagendijk, J.J.W., additional, and Raaymakers, B.W., additional

Published
2018
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38. PO-0863: “First in Man” treatments with the MRI-linac provide clinical proof of the concept

Author

Jürgenliemk-Schulz, I.M., primary, Raaymakers, B.W., additional, Van Asselen, B., additional, Bol, G.H., additional, Brown, K.J., additional, Doornaert, P., additional, De Groot-van Breugel, E.N., additional, Hackett, S.L., additional, Kasperts, N., additional, Kiekebosch, I.H., additional, Kerkmeijer, L.G.W., additional, Kok, J.G.M., additional, Kotte, A.N.T., additional, Meijers, L.T.C., additional, Nomden, C.N., additional, Pais, B.R., additional, Philippens, M.E.P., additional, Sikkes, G.G., additional, Tersteeg, J.H.A., additional, Tijssen, R.H.N., additional, Wolthaus, J.W.H., additional, Woodings, S.J., additional, and Lagendijk, J.J.W., additional

Published
2018
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48. OC-0163: Online workflow for the First-in-Man study on bone metastases at the MRI-linear accelerator

Author

Meijers, L.T.C., primary, Hoogcarspel, S.J., additional, Kotte, A.N.T.J., additional, Nomden, C.N.N., additional, Sikkes, G.G., additional, Kiekebosch, I.H., additional, Groot de, E.N., additional, Bol, G.H., additional, Asselen van, B., additional, Jurgenliemk-Schulz, I.M., additional, Kerkmeijer, L.G.W., additional, and Raaymakers, B.W., additional

Published
2017
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49. PO-0905: (Semi-)Automatic contouring strategies for rectal boost treatment on the MR-Linac

Author

Nomden, C.N., primary, Intven, M.P.W., additional, Kotte, A.N.T.J., additional, Kiekebosch, I.H., additional, Mook, S., additional, Jürgenliemk-Schulz, I.M., additional, Sikkes, G.G., additional, Meijers, L.T.C., additional, De Groot, E.N., additional, Bol, G.H., additional, Van Asselen, B., additional, Kerkmeijer, L.G.W., additional, and Raaymakers, B.W., additional

Published
2017
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