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Periprosthetic infections with problematic and multiresistant pathogens represent a great challenge for trauma surgeons, especially when repetitive surgical débridement combined with calculated i.v. antibiotic treatment does not lead to resolution of the infection. This can necessitate a deviation from state of the art treatment concepts, such as the additive implementation of a rifampicin-loaded polymethyl methacrylate (PMMA) spacers.Periprothetische Infektionen mit Problemkeimen und multiresistenten Erregern stellen den behandelnden Chirurgen immer wieder vor große Herausforderungen, insbesondere wenn repetitive chirurgische Débridements in Kombination mit einer kalkulierten i.v.-Antibiotika-Therapie nicht zur Infektsanierung führen. Dies kann u. U. ein Abweichen von bestehenden Therapiekonzepten erfordern. Beispielhaft wird der Einsatz eines additiv mit Rifampicin beladenen Polymethylmethacrylat(PMMA)-Spacer beschrieben.

Die Vision: Ein Chemiewerk aus Containern, die per Lkw, Schiff oder Zug an den Standort gebracht werden und binnen Stunden den Betrieb aufnehmen.

The H2020 BioMOre project (www.biomore.info, Grant Agreement #642456) tests the feasibility of in-situ bioleaching of copper in deep subsurface deposits in the Rudna Mine, Poland. Copper is leached using biologically produced ferric iron solution, which is recycled back to the in-situ reactor after re-oxidation by iron-oxidizing bacteria (IOB). From a post operational point of view, it is important that the biological processes applied during the operation can be controlled and terminated. Our goal was to determine the possibility to use natural saline mine water for the inactivation of introduced IOB remaining in the in-situ reactor after completion of the leaching process of the Kupferschiefer ore. Aerobic and anaerobic microcosms containing acid-leached (pH 2) sandstone or black shale from the Kupferschiefer in the Rudna mine were further leached with the effluent from an iron-oxidizing bioreactor, at a temperature of 30°C, for 10 days, to simulate in-situ leaching. After the removal of the iron solution, residing IOB were inactivated by filling the microcosms with saline water (65 g L-1 Cl-) originating from the mine. The saline water completely inactivated the IOB and the naturally occurring saline water of the mine can be used for long-term post process inactivation of bioleaching microorganisms.

Jarosite is a typical stream of zinc refineries, with high production rates and possible release of metal-contaminated seepage waters during long-term storage in respective disposal sites. Jarosite contains remarkable concentrations of valuable metals, like several weight percentages of zinc and lead, in addition to lower concentrations of copper, silver, germanium, gallium and indium. In this study, jarosite was treated with reductive and oxidative bioleaching for valuable metals recovery. The reductive bioleaching was seen to enhance iron liberation, by transforming the dissolved Fe(III) to Fe(II), while in the oxidative bioleaching iron liberation was lower. Zinc, copper, indium, gallium and germanium dissolution rates were rather identical with both methods. In reactor experiments, the zinc and copper yields were higher than in flask experiments resulting at best in the leaching yield of 35% and 38% for zinc and copper, respectively. Indium and gallium yields were between 5-8%, but approximately 40% of germanium was leached.