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3. A community-based strategy to eliminate hepatitis C among people who inject drugs in Vietnam

Author

Laureillard, Didier, Nagot, Nicolas, Jarlais, Don Des, Feelemyer, Jonathan, Quillet, Catherine, Vallo, Roselyne, Moles, Jean-Pierre, Weiss, Laurence, Lemoine, Maud, Michel, Laurent, Khue, Pham Minh, Rapoud, Delphine, Binh, Nguyen Thanh, Hong, Tran Thi, Thanh Hang, Nguyen Thi, Hai, Phung Quang, Thom, Vu Thi, Duc, Cap Minh, Thuy Linh, Le Thi, Nhu Quynh, Bach Thi, Linh, Le Thuy, Thi hong, Nguyen, Thu Trang, Vu Thi, Vinh, Vu Hai, Thanh Huong, Nguyen Thi, Thia, Hoang Thi, Van Anh, Nguyen Thi, Sinh, Vu Thi, Hai Binh, Doan Thi, Van Luc, Nguyen, Thu Ha, Vu Thi, Nhung, Do Thi, Khoi, Bui Minh, Thien, Bui Thi, Vu Quang, La Thi, Toi, Le Huu, Luong, Hoang Thi, Thanh Phuong, Pham Thi, Lieu, Pham Thi, Thanh Mai, Pham Thi, Hoa, Trinh Thi, Thu Trang, Bui Thi, Thu Ha, Nguyen Thi, Xuyen, Nguyen Thi, Huong, Trinh Thi, Minh, Nguyen Thi, Thuy, Phung Thi, Thi Duyen, Tran, Que, Vu Thi, Dung, Nguyen Duc, Tuan, Nguyen Duc, Long, Nguyen Hoang, Hung, Nguyen Manh, Van Tu, Vu, Kien, Nguyen Thanh, Thu Hong, Pham Thi, Cuc, Truong Thi, Quan, Nguyen Minh, Lan, Nguyen Thi, Va, Nguyen Thi, Manh, Nguyen The, Van Cuong, Doan, Van Hoan, Pham, Kim Giang, Cao Thi, Hiep, Ha Quang, Ninh, Ngo Trong, Quan, Nguyen Anh, Bich Hop, Vu Thi, Thu, Nguyen Thi, Sau, Nguyen Thi, Van Tuan, Hoang, Nhan, Nguyen Huu, Tuan, Nguyen Quoc, Long, Le Tuan, Son, Vu Minh, Hoc, Tran Viet, Van Dinh, Nguyen, Hoang, Nguyen, Hung, Pham Thi, Binh, Trinh Thai, Hang, Le Thi, Quan, Hoang Dang, Thi Thanh, Nguyen, Loan, Le Thi, Cuong, La Cao, Van Ha, Tran, Van Thao, Tran, Truong, Nguyen Xuan, Hanh, Nguyen Duc, Loan, Nguyen Thi, Tung, Tran Lam, Lien, Tran Thi, Hai Oanh, Khuat Thi, Tuyet Thanh, Nham Thi, Thuy Linh, Bui Thi, Dien, Ngo Thi, Vickerman, Peter, Fraser, Hannah, Walker, Josephine, Trickey, Adam, Huong, Duong Thi, Thanh, Nham Thi Tuyet, Quynh, Bach Thi Nhu, Nguyen, Duc Quang, Lacombe, Karine, Des Jarlais, Don, and Moles, Jean Pierre

Published
2023
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4. “Maintaining HIV and HCV prevention and care for people who inject drugs despite COVID‐19 in Hai Phong, Vietnam”

Author

Giang, Hoang Thi, Duc, Nguyen Quang, Molès, Jean-Pierre, Vinh, Vu Hai, Nagot, Nicolas, Thanh, Nham Thi Tuyet, Huong, Duong Thi, Oanh, Khuat Thi Hai, Khue, Pham Minh, Mai, Le Sao, Trang, Nguyen Thu, Ngoc, Pham Thi, Quillet, Catherine, Feelemyer, Jonathan, Vallo, Roselyne, Michel, Laurent, Jarlais, Don Des, Laureillard, Didier, and Rapoud, Delphine

Published
2022
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5. A community-based intervention to decrease the prevalence of HIV viremia among people who inject drugs in Vietnam

Author

Duong, Huong Thi, Moles, Jean-Pierre, Pham, Khue Minh, Vallo, Roselyne, Hoang, Giang Thi, Vu, Vinh Hai, Khuat, Oanh Thi Hai, Nham, Thanh Tuyet Thi, Nguyen, Duc Quang, Quillet, Catherine, Rapoud, Delphine, Van de Perre, Philippe, Castellani, Joëlle, Feelemyer, Jonathan, Michel, Laurent, Laureillard, Didier, Jarlais, Don Des, and Nagot, Nicolas

Published
2022
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6. Assessment of a psychiatric intervention at community level for people who inject drugs in a low-middle income country: the DRIVE-Mind cohort study in Hai Phong, Viet Nam

Author

Michel, Laurent, Le, Sao Mai, Thi, Giang Hoang, Trouiller, Philippe, Thi, Huong Duong, Thi Hai, Oanh Khuat, Minh, Khue Pham, Vallo, Roselyne, Rapoud, Delphine, Quillet, Catherine, Nguyen, Thuy Linh, Nguyen, Quang Duc, NhamThi, Tuyet Thanh, Feelemyer, Jonathan, Hai, Vinh Vu, Moles, Jean-Pierre, Doan, Hong Quang, Laureillard, Didier, Des Jarlais, Don C., and Nagot, Nicolas

Published
2022
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8. Growth, clinical and neurodevelopmental outcomes at school age are similar for children who received 1-year lamivudine or lopinavir/ritonavir HIV prophylaxis in early life

Author

Nagot, Nicolas, Singata-Madliki, Mandisa, Cournil, Amandine, Nalugya, Joyce, Tassembedo, Souleymane, Quillet, Catherine, Tonga, Melany W., Tumwine, James, Meda, Nicolas, Kankasa, Chipepo, Mwiya, Mwiya, Bangirana, Paul, Peries, Marianne, Batting, Joanne, Engebretsen, Ingunn M. S., Tylleskär, Thorkild, Perre, Philippe Vande, Ndeezi, Grace, and Molès, Jean-Pierre

Published
2021
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9. Utility of self-report antiretroviral adherence for predicting HIV viral load among persons who inject drugs in Hai Phong Vietnam: assessing differences by methamphetamine use.

Author

Feelemyer, Jonathan, Des Jarlais, Don C., Nagot, Nicolas, Huong, Duong Thi, Oanh, Khuat Thi Hai, Khue, Pham Minh, Thi Giang, Hoang, Tuyet Thanh, Nham Thi, Cleland, Charles M., Arasteh, Kamyar, Caniglia, Ellen, Chen, Yu, Bart, Gavin, Moles, Jean Pierre, Vinh, Vu Hai, Vallo, Roselyne, Quillet, Catherine, Rapoud, Delphine, Le, Sao M., and Michel, Laurent

Subjects
SELF-evaluation, PATIENT compliance, CROSS-sectional method, PREDICTIVE tests, PREDICTION models, ANTIRETROVIRAL agents, VIRAL load, METHAMPHETAMINE, RESEARCH funding, HIV-positive persons, DESCRIPTIVE statistics, SURVEYS, DRUGS, MEDICAL screening, SENSITIVITY & specificity (Statistics)
Abstract

In resource-limited settings, alternatives to HIV viral load testing may be necessary to monitor the health of people living with HIV. We assessed the utility of self-report antiretroviral therapy (ART) to screen for HIV viral load among persons who inject drugs in Hai Phong Vietnam, and consider differences by recent methamphetamine use. From 2016 to 2018 we recruited PWID through cross sectional surveys and collected self-report ART adherence and HIV viral load to estimate sensitivity, specificity, positive and negative predictive values (PPV, NPV) and likelihood ratios (LR+, LR-) for self-reported ART adherence as a screening test for HIV viral load. We used three HIV viral load thresholds: < 1000, 500 and 250 copies/mL; laboratory-confirmed HIV viral load was the gold standard. Among 792 PWID recruited, PPV remained above 90% regardless of recent methamphetamine use with slightly higher PPV among those not reporting recent methamphetamine use. The results remained consistent across all three HIV viral load thresholds. Our findings suggest that when HIV viral load testing is not possible, self-reported ART adherence may inform decisions about how to prioritize HIV viral load testing among PWID. The high PPV values suggest self-reported high ART adherence indicates likely HIV viral suppression, irrespective of methamphetamine use. [ABSTRACT FROM AUTHOR]

Published
2024
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10. HCV RNA Quantification by a Domestic Commercial Assay: A Case Study among People Who Inject Drugs in Vietnam

Author

Nhu, Quynh Bach Thi, primary, Thuy, Linh Le Thi, additional, Nguyen, Hong Thi, additional, Thanh, Binh Nguyen, additional, Rapoud, Delphine, additional, Quillet, Catherine, additional, Tran, Hong Thi, additional, Vallo, Roselyne, additional, Tuyet, Thanh Nham Thi, additional, Michel, Laurent, additional, Weiss, Laurence, additional, Perre, Philippe Vande, additional, Hai, Vinh Vu, additional, Nagot, Nicolas, additional, Hai, Oanh Khuat Thi, additional, Des Jarlais, Don, additional, Duong, Huong Thi, additional, Minh, Khue Pham, additional, Laureillard, Didier, additional, and Molès, Jean-Pierre, additional

Published
2023
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11. Utility of self-report antiretroviral adherence for predicting HIV viral load among persons who inject drugs in Hai Phong Vietnam: assessing differences by methamphetamine use

Author

Feelemyer, Jonathan, primary, Des Jarlais, Don C., additional, Nagot, Nicolas, additional, Huong, Duong Thi, additional, Oanh, Khuat Thi Hai, additional, Khue, Pham Minh, additional, Thi Giang, Hoang, additional, Tuyet Thanh, Nham Thi, additional, Cleland, Charles M., additional, Arasteh, Kamyar, additional, Caniglia, Ellen, additional, Chen, Yu, additional, Bart, Gavin, additional, Moles, Jean Pierre, additional, Vinh, Vu Hai, additional, Vallo, Roselyne, additional, Quillet, Catherine, additional, Rapoud, Delphine, additional, Le, Sao M., additional, Michel, Laurent, additional, Laureillard, Didier, additional, and Khan, Maria R., additional

Published
2023
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12. Mortality and its determinants in antiretroviral treatment-naive HIV-infected children with suspected tuberculosis: an observational cohort study

Author

Ay, Sao Sarady, Borand, Laurence, Chan, Malen, Chea, Phalla, Dim, Bunnet, Goyet, Sophie, Marcy, Olivier, Men, Nimul Roat, Pheng, Phearavin, Ramsay, Susan, Suom, Sophea, Tarantola, Arnaud, Te, Naisim, Than, Sreymom, Ung, Sovannary, Chhuk, Chorn, Huot, Chantheany, Kath, Sang Han, Khin, Sokoeun, Kim, Peou, Lim, Kim Eng, Lim, Phary, Lim, Vannareth, Nav, Yany, Pich, Boren, Tuy, Sotharin, Ung, Vibol, Chea, Phal, Chhraing, Sengtray, Chuop, Bophal, Hem, Ramy, Heng, Phanoeurn, Huon, Seng Hap, Khum, Sokhorn, Liv, Thear, Ly, Vichea, Moch, Makara, Neou, Leakheana, Rey, Phanith, Sath, Vina, Sun, Nopheavann, Chat, Pheron, Srey, Viso, Chheang, Sitha, Hor, Putchhat, Oum, Manory, Keo, Monorea, Kou, Sokchea, Cheng, Sokleaph, Kerleguer, Alexandra, Gomgnimbou, Michel, Kabore, Antoinette, Millogo, Anselme, Nacro, Boubacar, Nikiema, Zakari, Ouedraogo, Abdul Salam, Saidou, Sawadogo, Nouctara, Moumini, Sangare/Ouattara, Diane Ursule, Sanogo, Bintou, Sib Sié, Edgard, Zingué, Dézémon, Abiguide, Roger Ngoya, Assene Ngo'o, Patrice, Ateba Ndongo, Francis, Balla, Suzanne, Bolyse Mbouchong, Verlaine, Ehongo Amanya, Jean Marie, Eyangoh, Sara, Kaiyven, Afi Leslie, Koki Ndombo, Paul, Kokola Bayanak, Samuel Walter, Mapah Kampaing, Marie Josée, Mangoya, Elizabeth, Mvogo, Minkala, Ndongo, Jean Pierre, Ngassam, Laurence, Nanda, Francine, Ndjantou, Sylviane, Ndongo, Jean Audrey, Njind Nkoum, Marcelle, Njom Lend, Anne Esther, Nkembe, Angeline, Oyanche, Marie Flore, Taguebue, Jean-Voisin, Tejiokem, Mathurin, Tetang-Moyo, Suzy, Zebaze, Sylvie Georgette, Nguyen, Thi Oanh, Nguyen, Thi Ngoc Lan, Quillet, Catherine, Quoc, Khanh Lê, To, My Huong, Tran, Thi Kim Phung, Do, Chau Giang, Nguyen, Duc Bang, Nguyen, Ngo Vi Vi, Nguyen, Thi Hieu, Nguyen, Thi Thanh Thanh, Tran, Ngoc Duong, Vo, Duy An, Dang, Thi Xuan Lan, Do, Thi Kim Phuong, Dang, Thi Thanh Tuyen, Nguyen, Hoang Chau, Pham, Ngoc Tuong Vy, Truong, Huu Khanh, Do, Chau Viet, Huynh, Bich Ngoc, Le, Thi Thanh Thuy, Nguyen, Thi Thu Hiep, Tran, Ngoc Luu, Vu, Thien An, Tran, Huu Loc, Nguyen, Manh Hoang, Nguyen, Ngoc Lan, Van Nguyen, Thi Cao, Pham, Thu Hang, Phan, Dinh Quyen, Vo, Thi Ha, Truong, Xuan Lien, Vu, Xuan Thinh, Blanche, Stéphane, Delacourt, Christophe, Berteloot, Laureline, Carcelain, Guislaine, Godreuil, Sylvain, Fournier-Nicolle, Isabelle, Msellati, Philippe, Truong Huu, Khanh, Do Chau, Viet, Tran Ngoc, Duong, Ateba-Ndongo, Francis, Tetang-Ndiang, Suzie, and Neou, Leakhena

Published
2018
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13. HIV control programs reduce HIV incidence but not HCV incidence among people who inject drugs in HaiPhong, Vietnam

Author

Molès, Jean-Pierre, Vallo, Roselyne, Khue, Pham Minh, Huong, Duong Thi, Oanh, Khuat Thi Hai, Thoa, Nguyen Thi, Giang, Hoang Thi, Thanh, Nham Thi Tuyet, Vinh, Vu Hai, Bui Thi, Tuyet Anh, Peries, Marianne, Arasteh, Kamyar, Quillet, Catherine, Feelemyer, Jonathan, Michel, Laurent, Jarlais, Don Des, Laureillard, Didier, and Nagot, Nicolas

Published
2020
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14. Ending an HIV epidemic among persons who inject drugs in a middle-income country: extremely low HIV incidence among persons who inject drugs in Hai Phong, Viet Nam

Author

Des Jarlais, Don C., Huong, Duong Thi, Oanh, Khuat Thi Hai, Feelemyer, Jonathan P., Arasteh, Kamyar, Khue, Pham Minh, Giang, Hoang Thi, Thanh, Nham Thi Tuyet, Vinh, Vu Hai, Le, Sao Mai, Vallo, Roselyne, Quillet, Catherine, Rapoud, Delphine, Michel, Laurent, Laureillard, Didier, Moles, Jean Pierre, and Nagot, Nicolas

Published
2020
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15. Associations between methamphetamine use and lack of viral suppression among a cohort of HIV-positive persons who inject drugs in Hai Phong, Vietnam

Author

Feelemyer, Jonathan, Arasteh, Kamyar, Huong, Duong T., Oanh, Khuat T.H., Khue, Pham M., Giang, Hoang T., Thanh, Nham T.T., Moles, Jean Pierre, Vinh, Vu H., Vallo, Roselyne, Quillet, Catherine, Rapoud, Delphine, Le, Sao M., Michel, Laurent, Laureillard, Didier, Nagot, Nicolas, and Des Jarlais, Don C.

Published
2020
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16. Tuân thủ điều trị viêm gan C và một số yếu tố liên quan trong chăm sóc lồng ghép dựa vào cộng đồng cho người tiêm chích ma tuý tại Hải Phòng, 10/2018 – 06/2020

Author

Bình, Nguyễn Thanh, primary, Vinh, Vũ Hải, additional, Dương, Nguyễn Đức, additional, Hồng, Trần Thị, additional, Thanh, Nhâm Thị Tuyết, additional, Rapoud, Delphine, additional, Quillet, Catherine, additional, Moles, Jean-Pierre, additional, Vallo, Roselyne, additional, Laureillard, Didier, additional, Nagot, Nicolas, additional, Phước, Nguyễn Bá, additional, and Khuê, Phạm Minh, additional

Published
2023
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17. A community-based strategy to eliminate hepatitis C among people who inject drugs in Vietnam

Author

Nagot, Nicolas, primary, Binh, Nguyen Thanh, additional, Hong, Tran Thi, additional, Vinh, Vu Hai, additional, Quillet, Catherine, additional, Vallo, Roselyne, additional, Huong, Duong Thi, additional, Hai Oanh, Khuat Thi, additional, Thanh, Nham Thi Tuyet, additional, Rapoud, Delphine, additional, Quynh, Bach Thi Nhu, additional, Nguyen, Duc Quang, additional, Feelemyer, Jonathan, additional, Michel, Laurent, additional, Vickerman, Peter, additional, Fraser, Hannah, additional, Weiss, Laurence, additional, Lemoine, Maud, additional, Lacombe, Karine, additional, Des Jarlais, Don, additional, Khue, Pham Minh, additional, Moles, Jean Pierre, additional, Laureillard, Didier, additional, Nagot, Nicolas, additional, Jarlais, Don Des, additional, Moles, Jean-Pierre, additional, Thanh Hang, Nguyen Thi, additional, Hai, Phung Quang, additional, Thom, Vu Thi, additional, Duc, Cap Minh, additional, Thuy Linh, Le Thi, additional, Nhu Quynh, Bach Thi, additional, Linh, Le Thuy, additional, Thi hong, Nguyen, additional, Thu Trang, Vu Thi, additional, Thanh Huong, Nguyen Thi, additional, Thia, Hoang Thi, additional, Van Anh, Nguyen Thi, additional, Sinh, Vu Thi, additional, Hai Binh, Doan Thi, additional, Van Luc, Nguyen, additional, Thu Ha, Vu Thi, additional, Nhung, Do Thi, additional, Khoi, Bui Minh, additional, Thien, Bui Thi, additional, Vu Quang, La Thi, additional, Toi, Le Huu, additional, Luong, Hoang Thi, additional, Thanh Phuong, Pham Thi, additional, Lieu, Pham Thi, additional, Thanh Mai, Pham Thi, additional, Hoa, Trinh Thi, additional, Thu Trang, Bui Thi, additional, Thu Ha, Nguyen Thi, additional, Xuyen, Nguyen Thi, additional, Huong, Trinh Thi, additional, Minh, Nguyen Thi, additional, Thuy, Phung Thi, additional, Thi Duyen, Tran, additional, Que, Vu Thi, additional, Dung, Nguyen Duc, additional, Tuan, Nguyen Duc, additional, Long, Nguyen Hoang, additional, Hung, Nguyen Manh, additional, Van Tu, Vu, additional, Kien, Nguyen Thanh, additional, Thu Hong, Pham Thi, additional, Cuc, Truong Thi, additional, Quan, Nguyen Minh, additional, Lan, Nguyen Thi, additional, Va, Nguyen Thi, additional, Manh, Nguyen The, additional, Van Cuong, Doan, additional, Van Hoan, Pham, additional, Kim Giang, Cao Thi, additional, Hiep, Ha Quang, additional, Ninh, Ngo Trong, additional, Quan, Nguyen Anh, additional, Bich Hop, Vu Thi, additional, Thu, Nguyen Thi, additional, Sau, Nguyen Thi, additional, Van Tuan, Hoang, additional, Nhan, Nguyen Huu, additional, Tuan, Nguyen Quoc, additional, Long, Le Tuan, additional, Son, Vu Minh, additional, Hoc, Tran Viet, additional, Van Dinh, Nguyen, additional, Hoang, Nguyen, additional, Hung, Pham Thi, additional, Binh, Trinh Thai, additional, Hang, Le Thi, additional, Quan, Hoang Dang, additional, Thi Thanh, Nguyen, additional, Loan, Le Thi, additional, Cuong, La Cao, additional, Van Ha, Tran, additional, Van Thao, Tran, additional, Truong, Nguyen Xuan, additional, Hanh, Nguyen Duc, additional, Loan, Nguyen Thi, additional, Tung, Tran Lam, additional, Lien, Tran Thi, additional, Tuyet Thanh, Nham Thi, additional, Thuy Linh, Bui Thi, additional, Dien, Ngo Thi, additional, Walker, Josephine, additional, and Trickey, Adam, additional

Published
2023
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18. Gender, homelessness, hospitalization and methamphetamine use fuel depression among people who inject drugs: implications for innovative prevention and care strategies.

Author

Moulis, Lionel, Sao Mai Le, Vinh Vu Hai, Duong Thi Huong, Khuê Pham Minh, Khuat Thi Hai Oanh, Rapoud, Delphine, Quillet, Catherine, Tuyết Thanh Nham Thi, Vallo, Roselyne, Giang Thi Hoang, Moles, Jean-Pierre, Laureillard, Didier, Feelemyer, Jonathan, Des Jarlais, Don C., Michel, Laurent, and Nagot, Nicolas

Subjects
MIDDLE-income countries, METHAMPHETAMINE, AFFECTIVE disorders, MENTAL depression, HOMELESSNESS
Abstract

Background: The co-occurrence of substance use disorder and mental disorder, known as dual diagnosis, has a distressingly high prevalence among individuals grappling with either of these conditions. Mood disorders, especially depression, constitute a substantial burden for People Who Inject Drugs (PWID) and a significant public health concern in Vietnam. Identifying risk factors for depression in PWID is imperative for the development of targeted interventions. Methods: We enrolled PWID into a cohort using the respondent-driven sampling method. Over a 36-month period, we systematically tracked the emergence of depression and employed multiple imputation in conjunction with a mixed nonlinear model to pinpoint risk factors for depression in this demographic. At inclusion, depression was screened using the PHQ-2 questionnaire, and subsequent episodes of depression were assessed semi-annually using the CES-D8. Results: Three hundred and ninety-one PWID (26.6%) were depressed. Major risk factors for depression included being female, not having a permanent residency, having been hospitalized and using methamphetamine more than weekly. Other risk factors included age, being single, not having a health insurance card and not being on methadone. Limitations: The exclusion of missing visits and social desirability could have led to selection and information biases. In this observational study, confusion biases are possible despite our best efforts. Conclusion: Depression is alarmingly frequent in PWID. In this study taking in account the chronological relationship between sociodemographic and clinical factors and depression, risk factors were identified in this specific setting of lowto- middle income country. The findings highlight the need to develop innovative targeted psychiatric interventions with the help of supporting peers. [ABSTRACT FROM AUTHOR]

Published
2023
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19. Association between recent methamphetamine use, antiretroviral therapy and HIV viral load; a mediation analysis from a cohort of HIV positive persons who inject drugs in Hai Phong, Vietnam

Author

Feelemyer, Jonathan, primary, Des Jarlais, Don, additional, Nagot, Nicolas, additional, Duong Thi, Huong, additional, Thi Hai, Oanh Khuat, additional, Pham Minh, Khuê, additional, Hoang Thi, Giang, additional, Nham Thi Tuyet, Thanh, additional, Cleland, Charles M, additional, Arasteh, Kamyar, additional, Caniglia, Ellen, additional, Chen, Yu, additional, Bart, Gavin, additional, Moles, Jean Pierre, additional, Vu Hai, Vinh, additional, Vallo, Roselyne, additional, Quillet, Catherine, additional, Rapoud, Delphine, additional, Sao, Mai Le, additional, Michel, Laurent, additional, Laureillard, Didier, additional, and Khan, Maria R, additional

Published
2023
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20. How has the COVID-19 epidemic affected the risk behaviors of people who inject drugs in a city with high harm reduction service coverage in Vietnam? A qualitative investigation

Author

Le, Sao, Duong, Thi, Khuat, Thi, Pham, Minh, Vallo, Roselyne, Rapoud, Delphine, Quillet, Catherine, Nguyen, Quang, Nham, Thi Tuyet T., Hoang, Thi, Feelemyer, Jonathan, Vu, Hai, Moles, Jean‐pierre, Doan, Hong, Laureillard, Didier, Des Jarlais, Don, Nagot, Nicolas, Michel, Laurent, Nguyen, Trang Thu, Hoang, Giang Thi, Nguyen, Duc Quang, Nguyen, Anh Huu, Luong, Ngoc Anh, Duong, Huong Thi, Nham, Thanh Thi Tuyet, Khuat, Oanh Thi Hai, Pham, Khue Minh, Le, Mai Sao, Le, Giang Minh, Centre for Research and Training on Substance Abuse – HIV, Hanoi Medical University, Viet Nam, Supporting Community Development Initiatives [Hanoï, Vietnam], Hai Phong University of Medicine and Pharmacy [Hai Phong, Vietnam], Pathogenesis and Control of Chronic and Emerging Infections (PCCEI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles (UA)-Etablissement français du don du sang [Montpellier]-Université de Montpellier (UM), Institut National de la Santé et de la Recherche Médicale (INSERM), EFS, Université de Montpellier (UM), Hai Phong University of Medicine and Pharmacy, Haiphong, Vietnam., New York University College of Global Public Health, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, PARIS SACLAY UNIVERSITY, PIERRE NICOLE CENTER, and BONIZEC, Sandrine

Subjects
Harm reduction, Sex Workers, SARS-CoV-2, Research, [SDV]Life Sciences [q-bio], Public Health, Environmental and Occupational Health, Medicine (miscellaneous), COVID-19, Risk behaviors, Drug Users, [SDV] Life Sciences [q-bio], Psychiatry and Mental health, Risk-Taking, Vietnam, Communicable Disease Control, Humans, Female, Public aspects of medicine, RA1-1270, Substance Abuse, Intravenous, Pandemics, People who inject drugs
Abstract

Introduction The COVID-19 outbreak disproportionally affects vulnerable populations including people who inject drugs (PWID). Social distancing and stay-at-home orders might result in a lack of access to medical and social services, poorer mental health, and financial precariousness, and thus, increases in HIV and HCV risk behaviors. This article explores how the HIV/HCV risk behaviors of PWID in Haiphong, a city with high harm reduction service coverage in Vietnam, changed during the early phase of the COVID-19 pandemic, and what shaped such changes, using the risk environment framework. Method We conducted three focus group discussions with peer outreach workers in May 2020 at the very end of the first lockdown, and 30 in-depth interviews with PWID between September and October 2020, after the second wave of infection in Vietnam. Discussions and interviews centered on the impact of the COVID-19 pandemic on their lives, and how their drug use and sexual behaviors changed as a result of the pandemic. Results The national shutdown of nonessential businesses due to the COVID-19 epidemic caused substantial economic challenges to participants, who mostly were in a precarious financial situation before the start of the epidemic. Unsafe injection is no longer an issue among our sample of PWID in Haiphong thanks to a combination of different factors, including high awareness of injection-related HIV/HCV risk and the availability of methadone treatment. However, group methamphetamine use as a means to cope with the boredom and stress related to COVID-19 was common during the lockdown. Sharing of smoking equipment was a standard practice. Female sex workers, especially those who were active heroin users, suffered most from COVID-related financial pressure and may have engaged in unsafe sex. Conclusion While unsafe drug injection might no longer be an issue, group methamphetamine use and unsafe sex were the two most worrisome HIV/HCV risk behaviors of PWID in Haiphong during the social distancing and lockdown periods. These elevated risks could continue beyond the enforced lockdown periods, given PWID in general, and PWID who are also sex workers in particular, have been disproportionately affected during the global crisis.

Published
2022
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21. Gender Differences in HIV, HCV risk and Prevention Needs Among People who Inject drug in Vietnam

Author

Giang, Hoang Thi, primary, Duc, Nguyen Quang, additional, Khue, Pham Minh, additional, Quillet, Catherine, additional, Oanh, Khuat Thi Hai, additional, Thanh, Nham Thi Tuyet, additional, Vallo, Roselyne, additional, Feelemyer, Jonathan, additional, Vinh, Vu Hai, additional, Rapoud, Delphine, additional, Michel, Laurent, additional, Laureillard, Didier, additional, Moles, Jean Pierre, additional, Jarlais, Don Des, additional, Nagot, Nicolas, additional, and Huong, Duong Thi, additional

Published
2022
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22. Long-Term Persistence of Mitochondrial DNA Instability among HCV-Cured People Who Inject Drugs

Author

Durand, Mélusine, primary, Nagot, Nicolas, additional, Nhu, Quynh Bach Thi, additional, Vizeneux, Amélie, additional, Thuy, Linh Le Thi, additional, Duong, Huong Thi, additional, Thanh, Binh Nguyen, additional, Rapoud, Delphine, additional, Vallo, Roselyne, additional, Quillet, Catherine, additional, Tran, Hong Thi, additional, Michel, Laurent, additional, Tuyet, Thanh Nham Thi, additional, Hai, Oanh Khuat Thi, additional, Hai, Vinh Vu, additional, Feelemyer, Jonathan, additional, Vande Perre, Philippe, additional, Des Jarlais, Don, additional, Minh, Khue Pham, additional, Laureillard, Didier, additional, and Molès, Jean-Pierre, additional

Published
2022
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23. Mental Disorders Are Associated With Leukocytes Telomere Shortening Among People Who Inject Drugs

Author

Durand, Mélusine, primary, Nagot, Nicolas, additional, Michel, Laurent, additional, Le, Sao Mai, additional, Duong, Huong Thi, additional, Vallo, Roselyne, additional, Vizeneux, Amélie, additional, Rapoud, Delphine, additional, Giang, Hoang Thi, additional, Quillet, Catherine, additional, Thanh, Nham Thi Tuyet, additional, Hai Oanh, Khuat Thi, additional, Vinh, Vu Hai, additional, Feelemyer, Jonathan, additional, Vande Perre, Philippe, additional, Minh, Khue Pham, additional, Laureillard, Didier, additional, Des Jarlais, Don, additional, and Molès, Jean-Pierre, additional

Published
2022
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24. Reaching Hard-to-Reach People Who Use Drugs: A Community-Based Strategy for the Elimination of Hepatitis C

Author

Nagot, Nicolas, primary, D’Ottavi, Morgana, additional, Quillet, Catherine, additional, Debellefontaine, Anne, additional, Castellani, Joëlle, additional, Langendorfer, Nicolas, additional, Hanslik, Bertrand, additional, Guichard, Sylvain, additional, Baglioni, René, additional, Faucherre, Vincent, additional, Tuaillon, Edouard, additional, Pageaux, Georges-Philippe, additional, Laureillard, Didier, additional, and Donnadieu-Rigole, Hélène, additional

Published
2022
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25. Development and assessment of a community‐based screening tool for mental health disorders among people who inject drugs

Author

Le, Sao, Trouiller, Philippe, Duong, Thi, Khuat, Thi, Pham, Minh, Vallo, Roselyne, Rapoud, Delphine, Quillet, Catherine, Nguyen, Thuy, Nguyen, Quang, Nham, Thi Tuyet T, Hoang, Thi, Feelemyer, Jonathan, Vu, Hai, Moles, Jean-Pierre, Doan, Hong, Laureillard, Didier, Des Jarlais, Don, Nagot, Nicolas, Michel, Laurent, Team, Drive Study, Hai Phong University of Medicine and Pharmacy [Hai Phong, Vietnam], Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Centre Pierre Nicole [Paris], Supporting Community Development Initiatives [Hanoï, Vietnam], Pathogenesis and Control of Chronic and Emerging Infections (PCCEI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Université des Antilles (UA)-Etablissement français du don du sang [Montpellier], College of Global Public Health [New York], New York University [New York] (NYU), NYU System (NYU)-NYU System (NYU), Viet Tiep Hospital [Hai Phong, Vietnam], Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), and Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)

Subjects
medicine.medical_specialty, Health (social science), Vietnamese, Population, Medicine (miscellaneous), Developing country, people who inject drugs, Article, Drug Users, community setting, MESH: Drug Users, Prevalence, medicine, Humans, Mass Screening, MESH: Mental Disorders, MESH: Mass Screening, Substance Abuse, Intravenous, education, Depression (differential diagnoses), screening test, MESH: Prevalence, Mini-international neuropsychiatric interview, education.field_of_study, MESH: Humans, business.industry, MESH: Mental Health, Mental Disorders, Mental health, language.human_language, Family medicine, Respondent, language, MESH: Substance Abuse, Intravenous, Anxiety, medicine.symptom, business, mental health, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; Introduction: The prevalence of mental health disorders among people who use drugs is high and well documented. This hard-to-reach population faces a very low awareness and access to mental health care, especially in developing countries. The objectives of this study were to design and assess a quick screening tool (QST) that community-based organisations (CBO) could routinely apply to a Vietnamese population of people who inject drugs (PWID), in order to refer them appropriately to mental health specialists.Methods: We devised a tool that included nine questions covering anxiety, depression, suicide risk and psychotic symptomatology. Its use required no specific background and 2 h training. Specificity and sensitivity of the QST were assessed in a population of 418 PWID recruited via respondent driven sampling, using the Mini International Neuropsychiatric Interview questionnaire plus clinical evaluation as a reference standard. Acceptability was assessed using a self-administered anonymous questionnaire submitted to all CBO members who used the QST.Results: CBO members considered the QST easy to use, relevant and helpful to deal with mental health issues. Area under the curve for detection of any symptom using the QST was 0.770. The maximum sensitivity and specificity were reached with a cut-off of 2 [sensitivity was 71.1% (95% confidence interval 62.4, 78.8), specificity was 75.9% (70.5, 80.7)].Discussion and conclusions: The QST appeared to be both efficient and well accepted. Given the burden of mental health problems among hard-to-reach PWID in developing countries, community-based screenings such as this one could be a particularly appropriate response.

Published
2022
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26. Alarming tuberculosis rate among people who inject drugs in Vietnam

Author

Nagot, Nicolas, primary, Vu Hai, Vinh, additional, Thu Dong, Thuy Thi, additional, Thi Hai, Oanh Khuat, additional, Rapoud, Delphine, additional, Thi Hoang, Giang, additional, Quillet, Catherine, additional, Pham Minh, Khue, additional, Vallo, Roselyne, additional, Thi Nham, Thanh Tuyet, additional, Castellani, Joëlle, additional, Feelemyer, Jonathan, additional, Des Jarlais, Don C, additional, Nguyen, Phuong Lan, additional, Le Van, Hoi, additional, Nguyen Quang, Vo Luan, additional, Thi Duong, Huong, additional, Moles, Jean-Pierre, additional, and Laureillard, Didier, additional

Published
2021
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27. Mitochondrial Genotoxicity of Hepatitis C Treatment among People Who Inject Drugs

Author

Durand, Mélusine, primary, Nagot, Nicolas, additional, Nhu, Quynh Bach Thi, additional, Vallo, Roselyne, additional, Thuy, Linh Le Thi, additional, Duong, Huong Thi, additional, Thanh, Binh Nguyen, additional, Rapoud, Delphine, additional, Quillet, Catherine, additional, Tran, Hong Thi, additional, Michel, Laurent, additional, Tuyet, Thanh Nham Thi, additional, Hai, Oanh Khuat Thi, additional, Hai, Vinh Vu, additional, Feelemyer, Jonathan, additional, Perre, Philippe Vande, additional, Jarlais, Don Des, additional, Minh, Khue Pham, additional, Laureillard, Didier, additional, and Molès, Jean-Pierre, additional

Published
2021
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28. The methamphetamine epidemic among persons who inject heroin in Hai Phong, Vietnam

Author

Des Jarlais, Don C., primary, Feelemyer, Jonathan, additional, Arasteh, Kamyar, additional, Huong, Duong Thi, additional, Oanh, Khuat Thi Hai, additional, Khue, Pham Minh, additional, Giang, Hoang Thi, additional, Thanh, Nham Thi Tuyet, additional, Moles, Jean Pierre, additional, Vinh, Vu Hai, additional, Vallo, Roselyne, additional, Quillet, Catherine, additional, Rapoud, Delphine, additional, Michel, Laurent, additional, Laureillard, Didier, additional, and Nagot, Nicolas, additional

Published
2021
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29. Achieving an extremely high hepatitis C treatment success rate in people who inject drugs in Hai Phong, Vietnam: Results of the ANRS 12380 DRIVE-C study

Author

Vinh, Vu, Binh, Nguyen, Minh Khue, Pham, Huong, Duong, Thi, Khuat, Oanh, Hai, Thi, Nham, Thanh, Tuyet, Hong, Tran, Vallo, Roselyne, Quillet, Catherine, Rapoud, Delphine, Bach, Thi, Moles, Jean, Feelemyer, Jonathan, Michel, Laurent, Vickerman, Peter, Fraser, Hannah, Weiss, Laurence, Lemoine, Maud, Lacombe, Karine, Jarlais, Des, Nagot, Nicolas, Laureillard, Didier, and Vallo, Roselyne

Subjects
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology
Published
2021

30. Towards HCV elimination among people who inject drugs in Hai Phong, Vietnam: study protocol for an effectiveness-implementation trial evaluating an integrated model of HCV care (DRIVE-C: DRug use & Infections in ViEtnam–hepatitis C)

Author

Rapoud, Delphine, Quillet, Catherine, Pham Minh, Khue, Vu Hai, Vinh, Nguyen Thanh, Binh, Nham Thi Tuyet, Thanh, Tran Thi, Hong, Molès, Jean-Pierre, Vallo, Roselyne, Michel, Laurent, Feelemyer, Jonathan, Weiss, Laurence, Lemoine, Maud, Vickerman, Peter, Fraser, Hannah, Duong Thi, Huong, Khuat Thi Hai, Oanh, Des Jarlais, Don, Nagot, Nicolas, Laureillard, Didier, Pathogénèse et contrôle des infections chroniques (PCCI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre Hospitalier Universitaire de Montpellier (CHU Montpellier ), Haiphong University of Medicine and Pharmacy, Department of Infectious and Tropical Diseases, Viet Tiep Hospital, Center for Supporting Community Development Initiatives, Sexualité et soins (Genre, Sexualité, Santé) (CESP - INSERM U1018 - Equipe 7), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, College of Global Public Health [New York], New York University [New York] (NYU), NYU System (NYU)-NYU System (NYU), Department of Clinical Immunology, Hôtel Dieu Hospital, Liver Unit, Imperial College London, University of Bristol [Bristol], New York University College of Global Public Health, and Boutin, Marion

Subjects
Public health, Hepatology, [SDV]Life Sciences [q-bio], Infection control, Hepacivirus, Hepatitis C, Chronic, Antiviral Agents, Hepatitis C, [SDV] Life Sciences [q-bio], Infectious Diseases, Clinical trials, Pharmaceutical Preparations, Vietnam, THERAPEUTICS, Humans, Medicine, Substance Abuse, Intravenous, ComputingMilieux_MISCELLANEOUS
Abstract

Introduction In Vietnam, people who inject drugs (PWID), who are the major population infected by hepatitis C virus (HCV), remain largely undiagnosed and unlinked to HCV prevention and care despite recommended universal hepatitis C treatment. The data on the outcomes of HCV treatment among PWID also remain limited in resource-limited settings. The DRug use & Infections in ViEtnam–hepatitis C (DRIVE-C) study examines the effectiveness of a model of hepatitis C screening and integrated care targeting PWID that largely uses community-based organisations (CBO) in Hai Phong, Vietnam. In a wider perspective, this model may have the potential to eliminate HCV among PWID in this city.Methods and analysis The model of care comprises large community-based mass screening, simplified treatment with direct-acting antivirals (DAAs) and major involvement of CBO for PWID reaching out, linkage to care, treatment adherence and prevention of reinfection. The effectiveness of DAA care strategy among PWID, the potential obstacles to widespread implementation and its impact at population level will be assessed. A cost-effectiveness analysis is planned to further inform policy-makers. The enrolment target is 1050 PWID, recruited from the DRIVE study in Hai Phong. After initiation of pan-genotypic treatment consisting of sofosbuvir and daclatasvir administrated for 12 weeks, with ribavirin added in cases of cirrhosis, participants are followed-up for 48 weeks. The primary outcome is the proportion of patients with sustained virological response at week 48, that will be compared with a theoretical expected rate of 70%.Ethics and dissemination The study was approved by Haiphong University of Medicine and Pharmacy's Ethics Review Board and the Vietnamese Ministry of Health. The sponsor and the investigators are committed to conducting this study in accordance with ethics principles contained in the World Medical Association's Declaration of Helsinki (Ethical Principles for Medical Research Involving Human Subjects). Informed consent is obtained before study enrolment. The data are anonymised and stored in a secure database. The study is ongoing. Results will be presented at international conferences and submitted to international peer-review journals.Trial registration number NCT03537196.

Published
2020
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31. Towards HCV elimination amongpeople who inject drugs in Hai Phong,Vietnam: study protocol for aneffectiveness-implementation trialevaluating an integrated model of HCVcare (DRIVE-C: DRug use & Infectionsin ViEtnam–hepatitis C)

Author

Rapoud, Delphine, Quillet, Catherine, Minh, Khue Pham, Hai, Vinh Vu, Thanh, Binh Nguyen, Tuyet, Thanh Nham Thi, Thi, Hong Tran, Moles, Jean-Pierre, Vallo, Roselyne, Michel, Laurent, Feelemyer, Jonathan, Weiss, Laurence, Lemoine, Maud, Vickerman, Peter T, Fraser, Hannah, Thi, Huong Duong, Hai, Oanh Khuat Thi, Des Jarlais, Don, Nagot, Nicolas, and Laureillard, Didier

Abstract

Introduction In Vietnam, people who inject drugs (PWID), who are the major population infected by hepatitis C virus (HCV), remain largely undiagnosed and unlinked to HCV prevention and care despite recommended universal hepatitis C treatment. The data on the outcomes of HCV treatment among PWID also remain limited in resource-limited settings. The DRug use & Infections in ViEtnam–hepatitis C (DRIVE-C) study examines the effectiveness of a model of hepatitis C screening and integrated care targeting PWID that largely uses community-based organisations (CBO) in Hai Phong, Vietnam. In a wider perspective, this model may have the potential to eliminate HCV among PWID in this city. Methods and analysis The model of care comprises large community-based mass screening, simplified treatment with direct-acting antivirals (DAAs) and major involvement of CBO for PWID reaching out, linkage to care, treatment adherence and prevention of reinfection. The effectiveness of DAA care strategy among PWID, the potential obstacles to widespread implementation and its impact at population level will be assessed. A cost-effectiveness analysis is planned to further inform policy-makers. The enrolment target is 1050 PWID, recruited from the DRIVE study in Hai Phong. After initiation of pan-genotypic treatment consisting of sofosbuvir and daclatasvir administrated for 12 weeks, with ribavirin added in cases of cirrhosis, participants are followed-up for 48 weeks. The primary outcome is the proportion of patients with sustained virological response at week 48, that will be compared with a theoretical expected rate of 70%. Ethics and dissemination The study was approved by Haiphong University of Medicine and Pharmacy's Ethics Review Board and the Vietnamese Ministry of Health. The sponsor and the investigators are committed to conducting this study in accordance with ethics principles contained in the World Medical Association's Declaration of Helsinki (Ethical Principles for Medical Research Involving Human Subjects). Informed consent is obtained before study enrolment. The data are anonymised and stored in a secure database. The study is ongoing. Results will be presented at international conferences and submitted to international peer-review journals. Trial registration number NCT03537196.

Published
2020
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32. Ending an HIV epidemic among persons who inject drugs (PWID) in a middle-income country

Author

Des Jarlais, Don, Duong Thi, Huong, Khuat Thi Hai, Oanh, Feelemyer, Jonathan, Arasteh, Kamyar, Pham Minh, Khue, Hoang Thi, Giang, Nham Thi Tuyet, Thanh, Vu Hai, Vinh, Sao Mai, Le, Vallo, Roselyne, Quillet, Catherine, Rapoud, Delphine, Michel, Laurent, Laureillard, Didier, Moles, Jean Pierre, Nagot, Nicolas, New York University College of Global Public Health, Hai Phong University of Medicine and Pharmacy [Hai Phong, Vietnam], Supporting Community Development Initiatives [Hanoï, Vietnam], Department of Infectious and Tropical Diseases, Viet Tiep Hospital, Pathogénèse et contrôle des infections chroniques (PCCI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre Hospitalier Universitaire de Montpellier (CHU Montpellier ), Sexualité et soins (Genre, Sexualité, Santé) (CESP - INSERM U1018 - Equipe 7), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), and Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2020
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33. Alarming tuberculosis rate among people who inject Drug (PWID) in Vietnam

Author

Nagot, Nicolas, Vallo, Roselyne, Hai, Vinh, Hai, Oanh Khuat Thi, Rapoud, Delphine, Thi, Giang Hoang, Quillet, Catherine, Khue, Pham Minh, Nham, Thanh Thi Tuyet, Molès, Jean‐pierre, Des Jarlais, Don, Nguyen Phuong, Lan, Le, Hoi, Vo, Luan, Duong, Huong, Laureillard, Didier, and Vallo, Roselyne

Subjects
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology
Abstract

The prevalence of TB among PWID is very high, ranging from 1.6% to5.7%. PWID are 30 to 100 times more at risk of active TB than thegeneral population.Interestingly, the TB burden is very similar between HIV-positive andHIV negative PWID.n this cross sectional study, we showed that community-basedscreening was feasible and highly effective to identify TB cases inthis hard-to-reach population

Published
2020

34. Daily heroin injection and psychiatric disorders: A cross-sectional survey among People Who Inject Drugs (PWID) in Haiphong, Vietnam

Author

Le, Sao Mai, primary, Trouiller, Philippe, additional, Duong Thi, Huong, additional, Khuat Thi Hai, Oanh, additional, Pham Minh, Khue, additional, Vallo, Roselyne, additional, Rapoud, Delphine, additional, Quillet, Catherine, additional, Nguyen, Thuy Linh, additional, Nguyen, Quang Duc, additional, NhamThi, Tuyet Thanh, additional, Hoang Thi, Giang, additional, Feelemyer, Jonathan, additional, Hai, Vinh Vu, additional, Moles, Jean-Pierre, additional, Doan, Hong Quang, additional, Laureillard, Didier, additional, Des Jarlais, Don C., additional, Nagot, Nicolas, additional, and Michel, Laurent, additional

Published
2020
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35. Towards Targeted Interventions in Low- and Middle-Income Countries: Risk Profiles of People Who Inject Drugs in Haiphong (Vietnam)

Author

Riondel, Adeline, primary, Huong, Duong Thi, additional, Michel, Laurent, additional, Peries, Marianne, additional, Oanh, Khuat Thi Hai, additional, Khue, Pham Minh, additional, Thanh, Nham Thi Tuyet, additional, Giang, Hoang Thi, additional, Vallo, Roselyne, additional, Cournil, Amandine, additional, Rapoud, Delphine, additional, Quillet, Catherine, additional, Laureillard, Didier, additional, Vinh, Vu Hai, additional, Moles, Jean-Pierre, additional, Feelemyer, Jonathan, additional, Hammett, Ted, additional, Jarlais, Don Des, additional, and Nagot, Nicolas, additional

Published
2020
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36. Alarming Tuberculosis Rate Among People Who Inject Drugs in Vietnam.

Author

Nagot, Nicolas, Hai, Vinh Vu, Dong, Thuy Thi Thu, Hai, Oanh Khuat Thi, Rapoud, Delphine, Hoang, Giang Thi, Quillet, Catherine, Minh, Khue Pham, Vallo, Roselyne, Nham, Thanh Tuyet Thi, Castellani, Joëlle, Feelemyer, Jonathan, Jarlais, Don C Des, Nguyen, Lan Phuong, Le, Hoi Van, Nguyen, Nhung Viet, Vo, Luan Nguyen Quang, Duong, Huong Thi, Moles, Jean-Pierre, and Laureillard, Didier

Subjects
TUBERCULOSIS, HIV, HIV infections, VIRAL load, HIV-positive persons
Abstract

Background The tuberculosis (TB) epidemic is not homogeneous in the general population but presents high-risk groups. People who inject drugs (PWID) are such a group. However, TB among PWID remains largely undocumented. Our goal was to assess the prevalence of TB and the risk factors associated with TB among PWID in Vietnam. Methods We implemented a cross-sectional survey among 2 community-based cohorts of human immunodeficiency virus (HIV)-positive and HIV-negative PWID in Hai Phong. Participants were screened for TB using questions on TB symptoms. Those who reported any symptom were accompanied by peers to the TB clinic for chest x-ray. If the latter was abnormal, a sputum was collected to perform an Xpert MTB/RIF test. Results A total of 885 PWID were screened for TB. For both cohorts, most PWID were male (>90.0%), with a median age of 42 years. Beside heroin injection, 52.5% of participants reported smoking methamphetamine, and 63.2% were on methadone. Among HIV-positive PWID (N = 451), 90.4% were on antiretroviral therapy and 81.6% had a viral load <1000 copies/mL. Using a complete-case analysis, the estimated TB prevalence was 2.3% (95% confidence interval [CI], 1.0–4.5) and 2.1% (95% CI, 0.8–4.2) among HIV-positive and HIV-negative people, respectively. Living as a couple, arrest over the past 6 months, homelessness, and smoking methamphetamine were independently associated with TB but not HIV infection. Conclusions In the context of very large antiretroviral therapy coverage, this extremely high rate of TB among PWID requires urgent actions. [ABSTRACT FROM AUTHOR]

Published
2022
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37. Using large-scale respondent driven sampling to monitor the end of an HIV epidemic among persons who inject drugs in Hai Phong, Viet Nam.

Author

Des Jarlais, Don C., Arasteh, Kamyar, Huong, Duong Thi, Oanh, Khuat Thi Hai, Feelemyer, Jonathan P., Khue, Pham Minh, Giang, Hoang Thi, Thanh, Nham Thi Tuyet, Vinh, Vu Hai, Le, Sao Mai, Vallo, Roselyne, Quillet, Catherine, Rapoud, Delphine, Michel, Laurent, Laureillard, Didier, Moles, Jean Pierre, and Nagot, Nicolas

Subjects
MIDDLE-income countries, SNOWBALL sampling, DRUG utilization, HIV, EPIDEMICS, RESPONDENTS
Abstract

Aims: To describe the use of large-scale respondent driven sampling (RDS) surveys to demonstrate the "end of an HIV epidemic" (HIV incidence < 0.5/100 person-years) among persons who inject drugs (PWID) in a middle-income country. Large sample sizes are needed to convincingly demonstrate very low incidence rates. Methods: 4 large surveys (Ns approximately 1500 each) were conducted among PWID in Hai Phong, Vietnam in 2016–2019. Respondent driven sampling (RDS) with a modification to add snowball sampling was used for recruiting participants. HIV incidence was measured through recency testing, repeat participants across multiple surveys and in a cohort study of PWID recruited from the surveys. RDS analytics (time to equilibria and homophilies for major variables) were used to assess similarities/differences in RDS only versus RDS plus snowball recruiting. Characteristics were compared among respondents recruited through standard RDS recruitment versus through snowball sampling. An overall assessment of the robustness of RDS to modification was made when adding a snowball sampling recruitment. Results: RDS recruiting was very efficient in the first 5 weeks of each survey with approximately 180 respondents recruited per week. Recruiting then slowed considerably, and snowball sampling (permitting an individual respondent to recruit large numbers of new respondents) was added to the existing RDS recruiting. This led to recruiting within 13–14 weeks of 1383, 1451, 1444 and 1268 respondents, close to the target of 1500 respondents/survey. Comparisons of participants recruited through standard RDS method and respondents recruited through snowball methods showed very few significant differences. RDS analytics (quickly reaching equilibria, low homophilies) were favorable for both RDS recruited and total numbers of participants in each survey. DRug use and Infections in ViEtnam (DRIVE) methods have now been officially adopted in other provinces. Conclusions: RDS appears to be quite robust with respect to adding a modest number of participants recruited through snowball sampling. Large sample sizes can provide compelling evidence for "ending an HIV epidemic" to policy makers in a PWID population in a middle income country setting. [ABSTRACT FROM AUTHOR]

Published
2021
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38. Facteurs associés aux symptoms psychiatriques dans une cohort de personnes usagères de drogues injectables (UDI) à Haiphong, Vietnam et implications cliniques

Author

Pham Minh, Khue, Laurent, Michel, Duongi, H, Khuat, Oanh Hai Thi, Rapoud, Delphine, Quillet, Catherine, Nham, Thanh Tuyet Thi, Giang, Hoang Thi, Feelemyer, Jonathan, Hai, Vinh Vu, Laureillard, Didier, Des Jarlais, Don, Nagot, Nicolas, Pathogénèse et contrôle des infections chroniques (PCCI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Montpellier (CHU Montpellier )-Université de Montpellier (UM), Icahn School of Medicine at Mount Sinai [New York] (MSSM), and Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

39. An improved HIV care cascade to assess HIV control programs among people who inject drugs.

Author

Molès, Jean-Pierre, primary, Peries, Marianne, additional, Huong, Duong Thi, additional, Lien, Truong Thi Xuan, additional, Vallo, Roselyne, additional, Barrail-Tran, Aurélie, additional, Giang, Hoang Thi, additional, Thanh, Nham Thi Tuyet, additional, Khue, Pham Minh, additional, Vinh, Vu Hai, additional, Arasteh, Kamyar, additional, Rapoud, Delphine, additional, Quillet, Catherine, additional, Feelemyer, Jonathan, additional, Michel, Laurent, additional, Oanh, Khuat Thi Hai, additional, Jarlais, Don Des, additional, Laureillard, Didier, additional, and Nagot, Nicolas, additional

Published
2019
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40. A new plan for extended paediatric HIV testing is needed in Africa

Author

Molès, Jean-Pierre, primary, Méda, Nicolas, additional, Kankasa, Chipepo, additional, Tumwine, James, additional, Singata-Madliki, Mandisa, additional, Tassemdebo, Souleymane, additional, Mwiya, Mwiya, additional, Ndeezi, Grace, additional, Batting, Joanne, additional, Tylleskar, Thorkild, additional, Quillet, Catherine, additional, Peries, Marianne, additional, Van de Perre, Philippe, additional, and Nagot, Nicolas, additional

Published
2019
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41. Psychiatric Comorbidities among People Who Inject Drugs in Hai Phong, Vietnam: The Need for Screening and Innovative Interventions

Author

Pham Minh, Khue, primary, Vallo, Roselyne, additional, Duong Thi, Huong, additional, Khuat Thi Hai, Oanh, additional, Jarlais, Don C. Des, additional, Peries, Marianne, additional, Le, Sao Mai, additional, Rapoud, Delphine, additional, Quillet, Catherine, additional, Nham Thi, Tuyet Thanh, additional, Hoang Thi, Giang, additional, Feelemyer, Jonathan, additional, Vu Hai, Vinh, additional, Moles, Jean-Pierre, additional, Pham Thu, Xanh, additional, Laureillard, Didier, additional, Nagot, Nicolas, additional, Michel, Laurent, additional, and Study Team, DRIVE, additional

Published
2018
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42. Increased Methamphetamine Use among Persons Who Inject Drugs in Hai Phong, Vietnam, and the Association with Injection and Sexual Risk Behaviors

Author

Feelemyer, Jonathan, primary, Duong Thi, Huong, additional, Khuê Pham, Minh, additional, Hoang Thi, Giang, additional, Thi Tuyet Thanh, Nham, additional, Thi Hai Oanh, Khuat, additional, Arasteh, Kamyar, additional, Moles, Jean Pierre, additional, Vu Hai, Vinh, additional, Vallo, Roselyne, additional, Quillet, Catherine, additional, Rapoud, Delphine, additional, Michel, Laurent, additional, Hammett, Ted, additional, Laureillard, Didier, additional, Nagot, Nicolas, additional, and Des Jarlais, Don, additional

Published
2018
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43. Using dual capture/recapture studies to estimate the population size of persons who inject drugs (PWID) in the city of Hai Phong, Vietnam

Author

Des Jarlais, Don, primary, Khue, Pham Minh, additional, Feelemyer, Jonathan, additional, Arasteh, Kamyar, additional, Thi Huong, Duong, additional, Thi Hai Oanh, Khuat, additional, Thi Giang, Hoang, additional, Thi Tuyet Thanh, Nham, additional, Vinh, Vu Hai, additional, Heckathorn, Douglas D., additional, Moles, Jean Pierre, additional, Vallo, Roselyne, additional, Quillet, Catherine, additional, Rapoud, Delphine, additional, Michel, Laurent, additional, Laureillard, Didier, additional, Hammett, Ted, additional, and Nagot, Nicolas, additional

Published
2018
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44. Mortality and its determinants in antiretroviral treatment-naive HIV-infected children with suspected tuberculosis: an observational cohort study

Author

Marcy, Olivier, primary, Tejiokem, Mathurin, additional, Msellati, Philippe, additional, Truong Huu, Khanh, additional, Do Chau, Viet, additional, Tran Ngoc, Duong, additional, Nacro, Boubacar, additional, Ateba-Ndongo, Francis, additional, Tetang-Ndiang, Suzie, additional, Ung, Vibol, additional, Dim, Bunnet, additional, Neou, Leakhena, additional, Berteloot, Laureline, additional, Borand, Laurence, additional, Delacourt, Christophe, additional, Blanche, Stéphane, additional, Ay, Sao Sarady, additional, Chan, Malen, additional, Chea, Phalla, additional, Goyet, Sophie, additional, Marcy, Olivier, additional, Men, Nimul Roat, additional, Pheng, Phearavin, additional, Ramsay, Susan, additional, Suom, Sophea, additional, Tarantola, Arnaud, additional, Te, Naisim, additional, Than, Sreymom, additional, Ung, Sovannary, additional, Chhuk, Chorn, additional, Huot, Chantheany, additional, Kath, Sang Han, additional, Khin, Sokoeun, additional, Kim, Peou, additional, Lim, Kim Eng, additional, Lim, Phary, additional, Lim, Vannareth, additional, Nav, Yany, additional, Pich, Boren, additional, Tuy, Sotharin, additional, Chea, Phal, additional, Chhraing, Sengtray, additional, Chuop, Bophal, additional, Hem, Ramy, additional, Heng, Phanoeurn, additional, Huon, Seng Hap, additional, Khum, Sokhorn, additional, Liv, Thear, additional, Ly, Vichea, additional, Moch, Makara, additional, Neou, Leakheana, additional, Rey, Phanith, additional, Sath, Vina, additional, Sun, Nopheavann, additional, Chat, Pheron, additional, Srey, Viso, additional, Chheang, Sitha, additional, Hor, Putchhat, additional, Oum, Manory, additional, Keo, Monorea, additional, Kou, Sokchea, additional, Cheng, Sokleaph, additional, Kerleguer, Alexandra, additional, Gomgnimbou, Michel, additional, Kabore, Antoinette, additional, Millogo, Anselme, additional, Nikiema, Zakari, additional, Ouedraogo, Abdul Salam, additional, Saidou, Sawadogo, additional, Nouctara, Moumini, additional, Sangare/Ouattara, Diane Ursule, additional, Sanogo, Bintou, additional, Sib Sié, Edgard, additional, Zingué, Dézémon, additional, Abiguide, Roger Ngoya, additional, Assene Ngo'o, Patrice, additional, Ateba Ndongo, Francis, additional, Balla, Suzanne, additional, Bolyse Mbouchong, Verlaine, additional, Ehongo Amanya, Jean Marie, additional, Eyangoh, Sara, additional, Kaiyven, Afi Leslie, additional, Koki Ndombo, Paul, additional, Kokola Bayanak, Samuel Walter, additional, Mapah Kampaing, Marie Josée, additional, Mangoya, Elizabeth, additional, Mvogo, Minkala, additional, Ndongo, Jean Pierre, additional, Ngassam, Laurence, additional, Nanda, Francine, additional, Ndjantou, Sylviane, additional, Ndongo, Jean Audrey, additional, Njind Nkoum, Marcelle, additional, Njom Lend, Anne Esther, additional, Nkembe, Angeline, additional, Oyanche, Marie Flore, additional, Taguebue, Jean-Voisin, additional, Tetang-Moyo, Suzy, additional, Zebaze, Sylvie Georgette, additional, Nguyen, Thi Oanh, additional, Nguyen, Thi Ngoc Lan, additional, Quillet, Catherine, additional, Quoc, Khanh Lê, additional, To, My Huong, additional, Tran, Thi Kim Phung, additional, Do, Chau Giang, additional, Nguyen, Duc Bang, additional, Nguyen, Ngo Vi Vi, additional, Nguyen, Thi Hieu, additional, Nguyen, Thi Thanh Thanh, additional, Tran, Ngoc Duong, additional, Vo, Duy An, additional, Dang, Thi Xuan Lan, additional, Do, Thi Kim Phuong, additional, Dang, Thi Thanh Tuyen, additional, Nguyen, Hoang Chau, additional, Pham, Ngoc Tuong Vy, additional, Truong, Huu Khanh, additional, Do, Chau Viet, additional, Huynh, Bich Ngoc, additional, Le, Thi Thanh Thuy, additional, Nguyen, Thi Thu Hiep, additional, Tran, Ngoc Luu, additional, Vu, Thien An, additional, Tran, Huu Loc, additional, Nguyen, Manh Hoang, additional, Nguyen, Ngoc Lan, additional, Van Nguyen, Thi Cao, additional, Pham, Thu Hang, additional, Phan, Dinh Quyen, additional, Vo, Thi Ha, additional, Truong, Xuan Lien, additional, Vu, Xuan Thinh, additional, Carcelain, Guislaine, additional, Godreuil, Sylvain, additional, and Fournier-Nicolle, Isabelle, additional

Published
2018
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45. A Treatment-Decision Score for HIV-Infected Children With Suspected Tuberculosis.

Author

Marcy, Olivier, Borand, Laurence, Ung, Vibol, Msellati, Philippe, Tejiokem, Mathurin, Khanh Truong Huu, Viet Do Chau, Duong Ngoc Tran, Ateba-Ndongo, Francis, Tetang-Ndiang, Suzie, Nacro, Boubacar, Sanogo, Bintou, Neou, Leakhena, Goyet, Sophie, Bunnet Dim, Pean, Polidy, Quillet, Catherine, Fournier, Isabelle, Berteloot, Laureline, and Carcelain, Guislaine

Published
2019
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46. Assessment of a psychiatric intervention at community level for people who inject drugs in a low-middle income country: the DRIVE-Mind cohort study in Hai Phong, Viet Nam

Author

Michel, Laurent, Le, Sao Mai, Thi, Giang Hoang, Trouiller, Philippe, Thi, Huong Duong, Hai, Oanh Khuat Thi, Minh, Khue Pham, Vallo, Roselyne, Rapoud, Delphine, Quillet, Catherine, Nguyen, Thuy Linh, Nguyen, Quang Duc, NhamThi, Tuyet Thanh, Feelemyer, Jonathan, Hai, Vinh Vu, Moles, Jean-Pierre, Doan, Hong Quang, Laureillard, Didier, Jarlais, Don C. Des, and Nagot, Nicolas

Abstract

Access to psychiatric care for people who inject drugs (PWID) is limited/absent and stigmatized in most low-middle-income countries (LMICs). Innovative interventions are needed. We aimed to describe and assess the impact of a community-based psychiatric intervention among PWID in Hai Phong, Vietnam

Published
2021
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47. A community-based strategy to eliminate hepatitis C among people who inject drugs in Vietnam.

Author

Nagot N, Binh NT, Hong TT, Vinh VH, Quillet C, Vallo R, Huong DT, Hai Oanh KT, Thanh NTT, Rapoud D, Quynh BTN, Nguyen DQ, Feelemyer J, Michel L, Vickerman P, Fraser H, Weiss L, Lemoine M, Lacombe K, Des Jarlais D, Khue PM, Moles JP, and Laureillard D

Abstract

Background: Towards hepatitis C elimination among people who inject drugs (PWID), we assessed the effectiveness of a strategy consisting of a community-based respondent-driven sampling (RDS) as wide screening, a simplified and integrated hospital-based care, and prevention of reinfection supported by community-based organisations (CBO), in Hai Phong, Vietnam., Methods: Adults who injected heroin were enrolled in a RDS survey implemented in two CBO premises. Rapid HIV and HCV tests were done on site, and blood was taken for HCV RNA testing. Those with detectable HCV RNA were referred with CBO support to three public hospitals for 12-week sofosbuvir/daclatasvir, plus ribavirin for patients with cirrhosis. Participants were followed-up 12 weeks post-treatment (SVR12) and 48 weeks after enrolment. The primary endpoint was the rate of undetectable HCV RNA participants at 48 weeks., Findings: Among the 1444 RDS survey participants, 875 had hepatitis C. Their median age was 41 years (IQR 36-47), 96% were males, 36% were HIV-coinfected. Overall, 686 (78.4%) started sofosbuvir/daclatasvirs, and 629 of the 647 (97.2%) patients tested at SVR12 were cured. At week 48 (581/608) 95.6% had undetectable HCV RNA, representing 66.4% of all PWID identified with hepatitis C. The reinfection rate after SVR12 was 4/100 person-years (95% CI: 2-7)., Interpretation: Our strategy, involving CBO and addressing all steps from wide HCV screening to prevention of reinfection, stands as a promising approach to eliminate HCV among PWID in low and middle-income countries., Funding: France ANRS|MIE (#ANRS12380). The RDS survey was implemented with grants from the NIDA (#R01DA041978) and ANRS|MIE (#ANRS12353)., Competing Interests: ML received fees from Cepheid and Gilead US, as well as consultancy fees from Gilead US, outside the submitted work. KL received grants or contracts from MSD, honoraria from Janssen and Gilead, and travel support from Gilead, outside the submitted work. DDJ received grants and contracts from U.S. Centers for Disease Control, outside the submitted work. PV grants and contracts from Gilead medical Sciences outside the submitted work. Other authors declare no competing interest., (© 2023 The Author(s).)

Published
2023
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48. Development and assessment of a community-based screening tool for mental health disorders among people who inject drugs.

Author

Le SM, Trouiller P, Duong TH, Khuat THO, Pham MK, Vallo R, Rapoud D, Quillet C, Nguyen TL, Nguyen QD, Nham TTT, Hoang TG, Feelemyer J, Vu HV, Moles JP, Doan HQ, Laureillard D, Des Jarlais DC, Nagot N, and Michel L

Subjects
Humans, Mass Screening, Mental Health, Prevalence, Drug Users, Mental Disorders diagnosis, Mental Disorders epidemiology, Mental Disorders psychology, Substance Abuse, Intravenous epidemiology, Substance Abuse, Intravenous psychology
Abstract

Introduction: The prevalence of mental health disorders among people who use drugs is high and well documented. This hard-to-reach population faces a very low awareness and access to mental health care, especially in developing countries. The objectives of this study were to design and assess a quick screening tool (QST) that community-based organisations (CBO) could routinely apply to a Vietnamese population of people who inject drugs (PWID), in order to refer them appropriately to mental health specialists., Methods: We devised a tool that included nine questions covering anxiety, depression, suicide risk and psychotic symptomatology. Its use required no specific background and 2 h training. Specificity and sensitivity of the QST were assessed in a population of 418 PWID recruited via respondent driven sampling, using the Mini International Neuropsychiatric Interview questionnaire plus clinical evaluation as a reference standard. Acceptability was assessed using a self-administered anonymous questionnaire submitted to all CBO members who used the QST., Results: CBO members considered the QST easy to use, relevant and helpful to deal with mental health issues. Area under the curve for detection of any symptom using the QST was 0.770. The maximum sensitivity and specificity were reached with a cut-off of 2 [sensitivity was 71.1% (95% confidence interval 62.4, 78.8), specificity was 75.9% (70.5, 80.7)]., Discussion and Conclusions: The QST appeared to be both efficient and well accepted. Given the burden of mental health problems among hard-to-reach PWID in developing countries, community-based screenings such as this one could be a particularly appropriate response., (© 2021 Australasian Professional Society on Alcohol and other Drugs.)

Published
2022
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49. Assessment of a psychiatric intervention at community level for people who inject drugs in a low-middle income country: the DRIVE-Mind cohort study in Hai Phong, Viet Nam.

Author

Michel L, Le SM, Thi GH, Trouiller P, Thi HD, Thi Hai OK, Minh KP, Vallo R, Rapoud D, Quillet C, Nguyen TL, Nguyen QD, NhamThi TT, Feelemyer J, Hai VV, Moles JP, Doan HQ, Laureillard D, Des Jarlais DC, and Nagot N

Abstract

Background: Access to psychiatric care for people who inject drugs (PWID) is limited/absent and stigmatized in most low-middle-income countries (LMICs). Innovative interventions are needed. We aimed to describe and assess the impact of a community-based psychiatric intervention among PWID in Hai Phong, Vietnam., Methods: In a cohort study with one year psychiatric follow-up, PWID diagnosed with a psychotic disorder, a major depressive episode, or suicide risk, were recruited from the wider Drug-Related Infections in ViEtnam (DRIVE) project in the city of Hai Phong. The community-based psychiatric intervention included specialized follow-up (free consultations with psychiatrists, free medication, referral to mental health department for hospitalization when necessary) and support from community-based organisations (case management, harm reduction, administrative support, linkage to HIV care, methadone maintenance treatment and mental health support). The main outcome was reduction/remission of symptoms. Access to and retention in psychiatric care, quality-of-life and stigmatization were also measured pre and post-intervention., Findings: Among the 1212 participants screened from March to May 2019, 271 met the inclusion criteria, 233 (86.3%) accepted the intervention and 170 completed the follow-up (72.9%). At inclusion, 80.6% were diagnosed with current depression, 44.7% with psychotic disorder and 42.4% with suicide risk. After a one-year follow-up, these proportions dropped to 15.9%, 21.8%, and 22.9% respectively. Quality-of-life and perceived stigma related to mental health were also significantly improved, while drug use decreased only marginally., Interpretation: Community-based psychiatric interventions are both feasible and efficient in the Vietnamese context. Similar interventions should be implemented and evaluated in other, different LMICs., Funding: : This work was supported by grants from NIDA (US) (#DA041978) and ANRS (France) (#13353). The funding agencies had no role in designing the research, data analyses, or preparation of the report., Competing Interests: The authors declare no conflict of interest., (© 2021 The Author(s).)

Published
2021
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