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Subsea wellhead systems are the crucial equipment for the development of oil and gas resources offshore, while the sealing device plays a vital role as the main component of the wellhead system. Once the seal fails, it is necessary to retrieve the original wellhead system and either repair the sealing device or reinstall a new one. This will result in a delay in normal production and an increase in development costs. Therefore, a novel subsea wellhead sealing device is designed. A finite element analysis model is developed to study the underwater wellhead sealing mechanism regarding the equivalent stress and contact stress. The research results show that as the driving block gradually increases from 4 mm to 12 mm, the stress of the 12 convex parts on the sealing body also increases. The maximum equivalent stress reaches 3.5 times the yield limit, indicating that it has entered the yield stage and can achieve a more effective seal. The analysis of the contact stress of the sealing body reveals that the contact stress of the driving block increases, leading to plastic deformation of the sealing body while driving it to achieve a complete seal. In general, the finite element simulation results are consistent with the engineering practice. By analyzing the sealing characteristics, it can serve as the foundation for designing and providing theoretical support for the optimization of the metal-sealing structure. [ABSTRACT FROM AUTHOR]

We have developed a KOH-promoted transition-metal-free synthesis of 2-substituted 4(3 H)-quinazolinones from anthranilamides and benzyl alcohols or cinnamyl alcohol with air as oxidant. The protocol is simple, practical, and cost saving. Graphical abstract: [Figure not available: see fulltext.] [ABSTRACT FROM AUTHOR]

Introduction: Earlier research has indicated that being exposed to polychlorinated dibenzo-p-dioxins (PCDDs) in the workplace can heighten the likelihood of cancer-related deaths. Nevertheless, there is limited information available regarding the connection between PCDD exposure and the risk of cancer mortality in the general population (i.e., individuals not exposed to these substances through their occupation)., Methods: The National Health and Nutrition Examination Survey (NHANES) detected PCDDs in the general population, and the death data were recently updated as of December 31, 2019. We conducted Cox regression analysis and controlled for covariates including age, gender, ethnicity, educational attainment, physical activity, alcohol intake, NHANES survey period, BMI category, cotinine concentration, and household earnings., Results: After accounting for confounding factors, the findings indicated that for each incremental rise of 1 log unit in 1,2,3,4,6,7,8,9-octachlorodibenzo-p-dioxin, there was a 76% rise in the likelihood of death from any cause, with a p value of 0.003. An increase of 1 log unit in the concentration of 1,2,3,4,6,7,8-heptachlorodibenzofuran could potentially lead to a 90% higher risk of cancer mortality, as indicated by a p value of 0.034 and a 95% confidence interval of 0.05-2.43. As the concentrations of 1,2,3,4,6,7,8-heptachlorodibenzofuran increased, the dose-response curve indicated a proportional rise in the risk of cancer mortality, accompanied by a linear p value of 0.044. The sensitivity analysis demonstrated that our findings were resilient., Discussion: In the general population, an elevated risk of cancer mortality was observed in PCDDs due to the presence of 1,2,3,4,6,7,8-heptachlorodibenzofuran. Mechanistic research is required to further confirm it., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Zheng, Zhang, Gao, Zhong, Qiu and Yan.)