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243 results on '"Prandi, Cristina"'

10. Asymmetric Reduction of Cyclic Imines by Imine Reductase Enzymes in Non‐Conventional Solvents.

Author

Arnodo, Davide, De Nardi, Federica, Parisotto, Stefano, De Nardo, Eugenio, Cananà, Stefania, Salvatico, Federica, De Marchi, Elisa, Scarpi, Dina, Blangetti, Marco, Occhiato, Ernesto G., and Prandi, Cristina

Subjects
IMINES, SUSTAINABLE development, ENZYMES, SUSTAINABILITY, AZEPINES, AMINATION, GLYCERIN
Abstract

The first enantioselective reduction of 2‐substituted cyclic imines to the corresponding amines (pyrrolidines, piperidines, and azepines) by imine reductases (IREDs) in non‐conventional solvents is reported. The best results were obtained in a glycerol/phosphate buffer 1 : 1 mixture, in which heterocyclic amines were produced with full conversions (>99 %), moderate to good yields (22–84 %) and excellent S‐enantioselectivities (up to >99 % ee). Remarkably, the process can be performed at a 100 mM substrate loading, which, for the model compound, means a concentration of 14.5 g L−1. A fed‐batch protocol was also developed for a convenient scale‐up transformation, and one millimole of substrate 1 a was readily converted into 120 mg of enantiopure amine (S)‐2 a with a remarkable 80 % overall yield. This aspect strongly contributes to making the process potentially attractive for large‐scale applications in terms of economic and environmental sustainability for a good number of substrates used to produce enantiopure cyclic amines of high pharmaceutical interest. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Antiherpetic Activity of a Root Exudate from Solanum lycopersicum.

Author

Bajetto, Greta, Arnodo, Davide, Biolatti, Matteo, Trifirò, Linda, Albano, Camilla, Pasquero, Selina, Gugliesi, Francesca, Campo, Eva, Spyrakis, Francesca, Prandi, Cristina, De Andrea, Marco, Dell'Oste, Valentina, Visentin, Ivan, and Blangetti, Marco

Subjects
PLANT exudates, SOLANUM, HUMAN herpesvirus 1, HERPESVIRUS diseases, HUMAN cytomegalovirus, TOMATOES
Abstract

The rise of drug resistance to antivirals poses a significant global concern for public health; therefore, there is a pressing need to identify novel compounds that can effectively counteract strains resistant to current antiviral treatments. In light of this, researchers have been exploring new approaches, including the investigation of natural compounds as alternative sources for developing potent antiviral therapies. Thus, this work aimed to evaluate the antiviral properties of the organic-soluble fraction of a root exudate derived from the tomato plant Solanum lycopersicum in the context of herpesvirus infections. Our findings demonstrated that a root exudate from Solanum lycopersicum exhibits remarkable efficacy against prominent members of the family Herpesviridae, specifically herpes simplex virus type 1 (HSV-1) (EC50 25.57 µg/mL, SI > 15.64) and human cytomegalovirus (HCMV) (EC50 9.17 µg/mL, SI 32.28) by inhibiting a molecular event during the herpesvirus replication phase. Moreover, the phytochemical fingerprint of the Solanum lycopersicum root exudate was characterized through mass spectrometry. Overall, these data have unveiled a novel natural product with antiherpetic activity, presenting a promising and valuable alternative to existing drugs. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Strigolactones as Broad-Spectrum Antivirals against β-Coronaviruses through Targeting the Main Protease Mpro

Author

Biolatti, Matteo, Blangetti, Marco, Melissa, Baggieri, Antonella, Marchi, Silvia, Gioacchini, Bajetto, Greta, Arnodo, Davide, Paola, Bucci, Raoul, Fioravanti, Maedeh, Kojouri, Bersani, Matteo, D'Arrigo, Giulia, Lydia, Siragusa, Ghinato, Simone, DE ANDREA, Marco, Gugliesi, Francesca, Albano, Camilla, Pasquero, Selina, Visentin, Ivan, Emilio, D’Ugo, Francesca, Esposito, Paolo, Malune, Enzo, Tramontano, Prandi, Cristina, Spyrakis, Francesca, Fabio, Magurano, and Dell'Oste, Valentina

Subjects
HCoV-OC43, antiviral screening, strigolactones, HCoV-OC43, SARS-CoV-2, Mpro, SARS-CoV-2, antiviral screening, strigolactones, Mpro
Published
2023

25. A structural homologue of the plant receptor D14 mediates responses to strigolactones in the fungal phytopathogen Cryphonectria parasitica

Author

Fiorilli, Valentina, primary, Forgia, Marco, additional, de Saint Germain, Alexandre, additional, D’Arrigo, Giulia, additional, Cornu, David, additional, Le Bris, Philippe, additional, Al‐Babili, Salim, additional, Cardinale, Francesca, additional, Prandi, Cristina, additional, Spyrakis, Francesca, additional, Boyer, François‐Didier, additional, Turina, Massimo, additional, and Lanfranco, Luisa, additional

Published
2022
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47. Strigolactones - Biology and Applications

Author

Prandi, Cristina

Subjects
plant physiology, plant hormones, plant hormones, agriculture, plant physiology, organic chemistry, agriculture, organic chemistry
Published
2019

48. From synthetic control to natural products: a focus on N-heterocycles

Author

Prandi, Cristina and Occhiato, Ernesto G

Subjects
Biological Products, alkaloids, bioactivity, natural compounds, piperidine, Agronomy and Crop Science, Insect Science, Heterocyclic Compounds
Abstract

Natural products containing a N-heterocycle motif are widespread in nature and medicinal plants, in particular, have proved to be a source of almost unlimited N-derived structures with high molecular diversity. Because of their intrinsic potential for use in both biomedical and agricultural applications, there is a general need for new compounds and for the synthesis of 'natural-inspired' analogues. Importantly, transition of a natural product from discovery to a 'market lead' is associated with an increasingly challenging demand for more of the compound, which cannot be met by isolation from natural plant sources, often due to low extraction yields and uneven availability of the plant source itself. Synthesis remains the most reliable approach to provide valuable products for the market. In this review, a comprehensive overview of our contribution to synthetic access to N-derived natural products is given. Major strengths of the proposed methodologies are discussed critically. © 2019 Society of Chemical Industry.

Published
2018

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