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According to statistical data given in the article the incidence of oropharyngeal cancer increases, despite the ease of access to the maxillofacial area and the possibility to make visual and manual examination of this site. It should be stressed that locally advanced oropharyngeal cancer of the III-IV stages was the first diagnosis in 82.9% of patients. It may be due to low level suspicion of primary care physicians. The paper considers risk factors for development of oropharyngeal cancer and presents the list of compulsory diagnostic tests. The authors suggest that recommended diagnostic algorithm will be helpful to a timely detection of precancer and cancer abnormalities in the oropharynx in order to minimize the time and to define the optimal scheduling of examination of a patient in specialized health care centers for early detection of cancer.