294 results on '"Polak, Sebastian"'
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2. 3D printing combined with biopredictive dissolution and PBPK/PD modeling optimization and personalization of pharmacotherapy: Are we there yet?
3. A novel physiologically based pharmacokinetic model of rectal absorption, evaluated and verified using clinical data on 10 rectally administered drugs
4. Physiologically based modelling of dermal absorption and kinetics of consumer-relevant chemicals: A case study with exposure to bisphenol A from thermal paper
5. Computational Methods as Part of Scientific Research in Cosmetic Sciences—Are We Using the Opportunity?
6. How PBPK Can Help to Understand Old Drugs and Inform their Dosing in Elderly: Amantadine Case Study
7. In Vitro Simulation of the Fasted Gastric Conditions and Their Variability to Elucidate Contrasting Properties of the Marketed Dabigatran Etexilate Pellet-Filled Capsules and Loose Pellets
8. Correction to: Open-access database of literature derived drug-related Torsade de Pointes cases
9. Open-access database of literature derived drug-related Torsade de Pointes cases
10. Selective laser sintering (SLS) technique for pharmaceutical applications—Development of high dose controlled release printlets
11. How circadian variability of the heart rate and plasma electrolytes concentration influence the cardiac electrophysiology – model-based case study
12. Development and verification of mechanistic vaginal absorption and metabolism model to predict systemic exposure after vaginal ring and gel application.
13. CardiacPBPK: A tool for the prediction and visualization of time-concentration profiles of drugs in heart tissue
14. Better prediction of the local concentration–effect relationship: the role of physiologically based pharmacokinetics and quantitative systems pharmacology and toxicology in the evolution of model-informed drug discovery and development
15. In VitroSimulation of the Fasted Gastric Conditions and Their Variability to Elucidate Contrasting Properties of the Marketed Dabigatran Etexilate Pellet-Filled Capsules and Loose Pellets
16. Can 3D Printed Tablets Be Bioequivalent and How to Test It: A PBPK Model Based Virtual Bioequivalence Study for Ropinirole Modified Release Tablets.
17. A Rational Approach to Predicting Immediate Release Formulation Behavior in Multiple Gastric Motility Patterns: A Combination of a Biorelevant Apparatus, Design of Experiments, and Machine Learning
18. Mechanistic Physiologically Based Pharmacokinetic (PBPK) Model of the Heart Accounting for Inter-Individual Variability: Development and Performance Verification
19. Physiologically based pharmacokinetic-quantitative systems toxicology and safety (PBPK-QSTS) modeling approach applied to predict the variability of amitriptyline pharmacokinetics and cardiac safety in populations and in individuals
20. Thorough QT (TQT) studies: concordance with torsadogenesis and an evolving cardiac safety testing paradigm
21. Data on ADME parameters of bisphenol A and its metabolites for use in physiologically based pharmacokinetic modelling
22. Artificial Intelligence That Predicts Sensitizing Potential of Cosmetic Ingredients with Accuracy Comparable to Animal and In Vitro Tests—How Does the Infotechnomics Compare to Other “Omics” in the Cosmetics Safety Assessment?
23. Am I or am I not proarrhythmic? Comparison of various classifications of drug TdP propensity
24. Virtual Clinical Trial Toward Polytherapy Safety Assessment: Combination of Physiologically Based Pharmacokinetic/Pharmacodynamic-Based Modeling and Simulation Approach With Drug-Drug Interactions Involving Terfenadine as an Example
25. Quantitative approach for cardiac risk assessment and interpretation in tuberculosis drug development
26. Drug–physiology interaction and its influence on the QT prolongation-mechanistic modeling study
27. In Vitro/In Vivo Translation of Synergistic Combination of MDM2 and MEK Inhibitors in Melanoma Using PBPK/PD Modelling: Part III
28. Mechanistic modeling of drug products applied to the skin: A workshop summary report
29. In Vitro/In Vivo Translation of Synergistic Combination of MDM2 and MEK Inhibitors in Melanoma Using PBPK/PD Modelling: Part I
30. The Role of Interaction Model in Simulation of Drug Interactions and QT Prolongation
31. Utilization of mechanistic modelling and simulation to analyse fenspiride proarrhythmic potency – Role of physiological and other non‐drug related parameters
32. Modelling and simulation approaches to support formulation optimization, clinical development and regulatory assessment of the topically applied formulations – Nimesulide solution gel case study
33. Mechanistic Modeling of In Vitro Skin Permeation and Extrapolation to In Vivo for Topically Applied Metronidazole Drug Products Using a Physiologically Based Pharmacokinetic Model
34. Quality Control Dissolution Data Is Biopredictive for a Modified Release Ropinirole Formulation: Virtual Experiment with the Use of Re-Developed and Verified PBPK Model
35. Mechanistic modeling of drug products applied to the skin: A workshop summary report.
36. Virtual Thorough QT (TQT) Trial—Extrapolation of In Vitro Cardiac Safety Data to In Vivo Situation Using Multi-Scale Physiologically Based Ventricular Cell-wall Model Exemplified with Tolterodine and Fesoterodine
37. Towards Bridging Translational Gap in Cardiotoxicity Prediction: an Application of Progressive Cardiac Risk Assessment Strategy in TdP Risk Assessment of Moxifloxacin
38. Top-down, Bottom-up and Middle-out Strategies for Drug Cardiac Safety Assessment via Modeling and Simulations
39. Real Patient and its Virtual Twin: Application of Quantitative Systems Toxicology Modelling in the Cardiac Safety Assessment of Citalopram
40. Multi‐phase multi‐layer mechanistic dermal absorption (MPML MechDermA) model to predict local and systemic exposure of drug products applied on skin
41. Dataset of in vitro measured chemicals neurotoxicity
42. Early Drug Discovery Prediction of Proarrhythmia Potential and Its Covariates
43. Development and Performance Verification of the PBPK Model for Antazoline and Its Metabolite and Its Utilization for Pharmacological Hypotheses Formulating
44. An open-access data set of pig skin anatomy and physiology for modelling purposes
45. 52651 Mapping skin properties in psoriasis for improved understanding of topical absorption.
46. Development of physiologically based pharmacokinetic model for the immediate release ropinirole tablets
47. Plasma vs heart tissue concentration in humans – literature data analysis of drugs distribution
48. Magnetic Core–Shell Molecularly Imprinted Nano-Conjugates for Extraction of Antazoline and Hydroxyantazoline from Human Plasma—Material Characterization, Theoretical Analysis and Pharmacokinetics
49. Utilization of mechanistic modelling and simulation to analyze fenspiride proarrhythmic potency–role of physiological and other non-drug related parameters
50. The database for in silico cardiac risk prediction tools
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