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Your search keyword '"Podlaha, Ondrej"' showing total 26 results
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26 results on '"Podlaha, Ondrej"'

1. Joint host-pathogen genomic analysis identifies hepatitis B virus mutations associated with human NTCP and HLA class I variation

Author

Xu, Zhi Ming, Gnouamozi, Gnimah Eva, Rüeger, Sina, Shea, Patrick R., Buti, Maria, Chan, Henry LY., Marcellin, Patrick, Lawless, Dylan, Naret, Olivier, Zeller, Matthias, Schneuing, Arne, Scheck, Andreas, Junier, Thomas, Moradpour, Darius, Podlaha, Ondrej, Suri, Vithika, Gaggar, Anuj, Subramanian, Mani, Correia, Bruno, Gfeller, David, Urban, Stephan, and Fellay, Jacques

Published
2024
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2. Changes in the gut microbiome associated with liver stiffness improvement in nonalcoholic steatohepatitis

Author

Sharpton, Suzanne R, Podlaha, Ondrej, Chuang, Jen-Chieh, Gindin, Yevgeniy, Myers, Robert P, and Loomba, Rohit

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Hepatitis, Digestive Diseases, Biomedical Imaging, Clinical Trials and Supportive Activities, Liver Disease, Clinical Research, Oral and gastrointestinal, biomarker, fibrosis, longitudinal, microbiome, nonalcoholic steatohepatitis, Pharmacology and Pharmaceutical Sciences, Clinical sciences
Abstract

BackgroundLongitudinal studies are needed to decipher mechanistic links between the gut microbiome and nonalcoholic steatohepatitis (NASH). We examined shifts in the gut microbiome in persons with NASH with improvement in liver stiffness measurement (LSM) by magnetic resonance (MR) elastography.MethodsGut microbial profiling was performed at baseline and study completion (24 weeks) using 16 S rRNA gene sequencing in 69 adults with biopsy-confirmed NASH and significant fibrosis (stages 2-3) enrolled in a multi-center randomized controlled trial evaluating selonsertib alone or in combination with simtuzumab. Differential abundance of bacterial taxa at baseline and end of study were examined in participants with and without longitudinal improvement in LSM. Gut microbial shifts that correlated with secondary outcomes, including reduction in MR imaging-derived proton density fat faction (MRI-PDFF) and histologic fibrosis regression were evaluated. Fecal samples from 32 healthy adults were profiled and genus-level multidimensional scaling was used to determine if microbial shifts in persons with NASH improvement represented a shift toward a healthy gut microbiome.ResultsShifts in abundance of 36 bacterial taxa including Lactobacillus (log2FC = -4.51, FDR

Published
2022

3. HIV rebound in HIV controllers is associated with a specific fecal microbiome profile

Author

Cai, Yanhui, primary, Podlaha, Ondrej, additional, Deeks, Steven G., additional, Brinson, Cynthia, additional, Ramgopal, Moti N., additional, DeJesus, Edwin, additional, Mills, Anthony, additional, Shalit, Peter, additional, Abdel‐Mohsen, Mohamed, additional, Zhang, Liao, additional, de Vries, Christiaan R., additional, Vendrame, Elena, additional, SenGupta, Devi, additional, and Wallin, Jeffrey J., additional

Published
2024
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4. Large-scale viral genome analysis identifies novel clinical associations between hepatitis B virus and chronically infected patients

Author

Podlaha, Ondrej, Gane, Edward, Brunetto, Maurizia, Fung, Scott, Chuang, Wan-Long, Pan, Calvin Q., Jiang, Zhaoshi, Liu, Yang, Bhardwaj, Neeru, Mukherjee, Prasenjit, Flaherty, John, Gaggar, Anuj, Subramanian, Mani, Izumi, Namiki, Shalimar, Lim, Young-Suk, Marcellin, Patrick, Buti, Maria, Chan, Henry L. Y., and Agarwal, Kosh

Published
2019
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5. Effect of tenofovir disoproxil fumarate treatment on intrahepatic viral burden and liver immune microenvironment in chronic hepatitis B patients with minimally elevated serum alanine aminotransferase

Author

Aggarwal, Abhishek, primary, Ramirez, Ricardo, additional, Pan, David, additional, Podlaha, Ondrej, additional, Wallin, Jeffrey, additional, Lin, Jaw-Town, additional, Tseng, Cheng-Hao, additional, Li, Li, additional, Diehl, Lauri, additional, Feierbach, Becket, additional, Fletcher, Simon, additional, Suri, Vithika, additional, and Hsu, Yao-Chun, additional

Published
2022
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6. Inhibition of Viral Replication Reduces Transcriptionally Active Distinct Hepatitis B Virus Integrations With Implications on Host Gene Dysregulation

Author

Hsu, Yao-Chun, primary, Suri, Vithika, additional, Nguyen, Mindie H., additional, Huang, Yen-Tsung, additional, Chen, Chi-Yi, additional, Chang, I-Wei, additional, Tseng, Cheng-Hao, additional, Wu, Chun-Ying, additional, Lin, Jaw-Town, additional, Pan, David Z., additional, Gaggar, Anuj, additional, and Podlaha, Ondrej, additional

Published
2022
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7. sj-docx-6-tag-10.1177_17562848221098243 – Supplemental material for Changes in the gut microbiome associated with liver stiffness improvement in nonalcoholic steatohepatitis

Author

Sharpton, Suzanne R., Podlaha, Ondrej, Chuang, Jen-Chieh, Gindin, Yevgeniy, Myers, Robert P., and Loomba, Rohit

Subjects
FOS: Clinical medicine, 111199 Nutrition and Dietetics not elsewhere classified, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, sj-docx-6-tag-10.1177_17562848221098243 for Changes in the gut microbiome associated with liver stiffness improvement in nonalcoholic steatohepatitis by Suzanne R. Sharpton, Ondrej Podlaha, Jen-Chieh Chuang, Yevgeniy Gindin, Robert P. Myers and Rohit Loomba in Therapeutic Advances in Gastroenterology

Published
2022
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8. sj-docx-7-tag-10.1177_17562848221098243 – Supplemental material for Changes in the gut microbiome associated with liver stiffness improvement in nonalcoholic steatohepatitis

Author

Sharpton, Suzanne R., Podlaha, Ondrej, Chuang, Jen-Chieh, Gindin, Yevgeniy, Myers, Robert P., and Loomba, Rohit

Subjects
FOS: Clinical medicine, 111199 Nutrition and Dietetics not elsewhere classified, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, sj-docx-7-tag-10.1177_17562848221098243 for Changes in the gut microbiome associated with liver stiffness improvement in nonalcoholic steatohepatitis by Suzanne R. Sharpton, Ondrej Podlaha, Jen-Chieh Chuang, Yevgeniy Gindin, Robert P. Myers and Rohit Loomba in Therapeutic Advances in Gastroenterology

Published
2022
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17. Differential Serum Cytokine Profiles in Patients with Chronic Hepatitis B, C, and Hepatocellular Carcinoma

Author

Estevez, Jacqueline, primary, Chen, Vincent L., additional, Podlaha, Ondrej, additional, Li, Biao, additional, Le, An, additional, Vutien, Philip, additional, Chang, Ellen T., additional, Rosenberg-Hasson, Yael, additional, Jiang, Zhaoshi, additional, Pflanz, Stefan, additional, Ge, Dongliang, additional, Gaggar, Anuj, additional, and Nguyen, Mindie H., additional

Published
2017
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18. Soluble intercellular adhesion molecule-1 is associated with hepatocellular carcinoma risk: multiplex analysis of serum markers

Author

Chen, Vincent L., primary, Le, An K., additional, Podlaha, Ondrej, additional, Estevez, Jacqueline, additional, Li, Biao, additional, Vutien, Philip, additional, Chang, Ellen T., additional, Rosenberg-Hasson, Yael, additional, Pflanz, Stefan, additional, Jiang, Zhaoshi, additional, Ge, Dongliang, additional, Gaggar, Anuj, additional, and Nguyen, Mindie H., additional

Published
2017
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19. ABCG2 regulates self-renewal and stem cell marker expression but not tumorigenicity or radiation resistance of glioma cells

Author

Wee, Boyoung, Pietras, Alexander, Ozawa, Tatsuya, Bazzoli, Elena, Podlaha, Ondrej, Antczak, Christophe, Westermark, Bengt, Nelander, Sven, Uhrbom, Lene, Forsberg-Nilsson, Karin, Djaballah, Hakim, Michor, Franziska, Holland, Eric C., Wee, Boyoung, Pietras, Alexander, Ozawa, Tatsuya, Bazzoli, Elena, Podlaha, Ondrej, Antczak, Christophe, Westermark, Bengt, Nelander, Sven, Uhrbom, Lene, Forsberg-Nilsson, Karin, Djaballah, Hakim, Michor, Franziska, and Holland, Eric C.

Abstract

Glioma cells with stem cell traits are thought to be responsible for tumor maintenance and therapeutic failure. Such cells can be enriched based on their inherent drug efflux capability mediated by the ABC transporter ABCG2 using the side population assay, and their characteristics include increased self-renewal, high stem cell marker expression and high tumorigenic capacity in vivo. Here, we show that ABCG2 can actively drive expression of stem cell markers and self-renewal in glioma cells. Stem cell markers and self-renewal was enriched in cells with high ABCG2 activity, and could be specifically inhibited by pharmacological and genetic ABCG2 inhibition. Importantly, despite regulating these key characteristics of stem-like tumor cells, ABCG2 activity did not affect radiation resistance or tumorigenicity in vivo. ABCG2 effects were Notch-independent and mediated by diverse mechanisms including the transcription factor Mef. Our data demonstrate that characteristics of tumor stem cells are separable, and highlight ABCG2 as a potential driver of glioma stemness.

Published
2016
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20. ABCG2 regulates self-renewal and stem cell marker expression but not tumorigenicity or radiation resistance of glioma cells

Author

Wee, Boyoung, primary, Pietras, Alexander, additional, Ozawa, Tatsuya, additional, Bazzoli, Elena, additional, Podlaha, Ondrej, additional, Antczak, Christophe, additional, Westermark, Bengt, additional, Nelander, Sven, additional, Uhrbom, Lene, additional, Forsberg-Nilsson, Karin, additional, Djaballah, Hakim, additional, Michor, Franziska, additional, and Holland, Eric C., additional

Published
2016
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